ref_db gene_id ref_id bit_score evalue info info_filtered category KOfam UHGV-1475708_3 K07099 40.7 0.00000000000093 K07099; uncharacterized protein NULL NULL PHROG UHGV-1475708_3 phrog_547 134.1 6.10001e-40 phosphoesterase phosphoesterase other UniRef90 UHGV-1475708_3 UniRef90_A0A0P0L840 124.0 3.38e-32 Phosphohydrolase (MutT/nudix family protein) Phosphohydrolase (MutT/nudix family protein) NULL eggNOG-mapper UHGV-1475708_3 435590.BVU_3762 122.0 2.02e-32 Calcineurin-like phosphoesterase superfamily domain Calcineurin-like phosphoesterase superfamily domain NULL Pfam UHGV-1475708_3 PF12850 NULL NULL Calcineurin-like phosphoesterase superfamily domain Calcineurin-like phosphoesterase superfamily domain Metallophos_2 COG UHGV-1475708_3 COG4186 NULL NULL Uncharacterized conserved protein MJ1445, calcineurin-like phosphoesterase superfamily NULL NULL structural_annotation UHGV-1475708_3 TIGR00024,COG4186 NULL NULL NULL NULL NULL eggNOG-mapper UHGV-1475708_5 742723.HMPREF9477_00917 55.1 0.0000000919 NULL NULL NULL PHROG UHGV-1475708_7 phrog_6660 72.5 1.3e-21 NULL NULL unknown function UniRef90 UHGV-1475708_7 UniRef90_A0A1Y4KZT6 93.2 9.42e-21 CYTH domain-containing protein CYTH domain-containing protein NULL eggNOG-mapper UHGV-1475708_7 748224.HMPREF9436_01441 89.4 4.74e-20 Psort location Cytoplasmic, score NULL NULL COG UHGV-1475708_7 COG2954 NULL NULL CYTH domain, found in class IV adenylate cyclase and various triphosphatases CYTH domain, found in class IV adenylate cyclase and various triphosphatases NULL structural_annotation UHGV-1475708_7 PF01928,TIGR00318,COG2954 NULL NULL NULL NULL NULL structural_annotation UHGV-1475708_15 COG3189 NULL NULL NULL NULL NULL PHROG UHGV-1475708_19 phrog_33451 71.5 4.7e-21 NULL NULL unknown function UniRef90 UHGV-1475708_21 UniRef90_A0A3A8YVS9 65.5 0.00000000000212 HPr family phosphocarrier protein HPr family phosphocarrier protein NULL eggNOG-mapper UHGV-1475708_21 1235797.C816_02046 58.9 0.000000000136 NULL NULL NULL structural_annotation UHGV-1475708_21 PF00381,TIGR01003,COG1925 NULL NULL NULL NULL NULL PHROG UHGV-1475708_25 phrog_23747 51.5 0.000000000000018 NULL NULL unknown function structural_annotation UHGV-1475708_25 NF040944 NULL NULL NULL NULL NULL KOfam UHGV-1475708_28 K08281 58.8 9e-17 pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] NULL PHROG UHGV-1475708_28 phrog_19305 85.1 8.6e-25 NULL NULL unknown function UniRef90 UHGV-1475708_28 UniRef90_R7N1L9 98.6 6.62e-23 Isochorismatase domain-containing protein Isochorismatase domain-containing protein NULL eggNOG-mapper UHGV-1475708_28 483218.BACPEC_02624 91.7 5.52e-21 Isochorismatase family Isochorismatase family NULL Pfam UHGV-1475708_28 PF00857 NULL NULL Isochorismatase family Isochorismatase family Isochorismatase COG UHGV-1475708_28 COG1335 NULL NULL Nicotinamidase-related amidase Nicotinamidase-related amidase NULL KOfam UHGV-1475708_29 K00948 72.8 3.4e-21 PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] NULL PHROG UHGV-1475708_29 phrog_619 196.1 0 ribose-phosphate pyrophosphokinase ribose-phosphate pyrophosphokinase other UniRef90 UHGV-1475708_29 UniRef90_UPI0013EEEA53 195.0 0 ribose-phosphate pyrophosphokinase ribose-phosphate pyrophosphokinase NULL eggNOG-mapper UHGV-1475708_29 1163671.JAGI01000002_gene1279 169.0 0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) NULL Pfam UHGV-1475708_29 PF00156 NULL NULL Phosphoribosyl transferase domain Phosphoribosyl transferase domain Pribosyltran COG UHGV-1475708_29 COG0462 NULL NULL Phosphoribosylpyrophosphate synthetase Phosphoribosylpyrophosphate synthetase NULL KOfam UHGV-1475708_30 K03462 360.7 0 NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12] NAMPT; nicotinamide phosphoribosyltransferase [EC:2.4.2.12] NULL PHROG UHGV-1475708_30 phrog_448 472.8 0 nicotinamide phosphoribosyl transferase nicotinamide phosphoribosyl transferase other UniRef90 UHGV-1475708_30 UniRef90_A0A494XH38 345.0 0 Nicotinate phosphoribosyltransferase Nicotinate phosphoribosyltransferase NULL eggNOG-mapper UHGV-1475708_30 1415774.U728_304 341.0 0 Nicotinate phosphoribosyltransferase (NAPRTase) family Nicotinate phosphoribosyltransferase (NAPRTase) family NULL Pfam UHGV-1475708_30 PF04095 NULL NULL Nicotinate phosphoribosyltransferase (NAPRTase) family Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase COG UHGV-1475708_30 COG1488 NULL NULL Nicotinic acid phosphoribosyltransferase Nicotinic acid phosphoribosyltransferase NULL structural_annotation UHGV-1475708_30 PF04095,PF17767,NF006629,COG1488 NULL NULL NULL NULL NULL PHROG UHGV-1475708_31 phrog_1238 56.6 4.1e-16 phosphoheptose isomerase phosphoheptose isomerase moron, auxiliary metabolic gene and host takeover UniRef90 UHGV-1475708_31 UniRef90_UPI0015D4BE51 107.0 1.06e-26 HAD family hydrolase HAD family hydrolase NULL eggNOG-mapper UHGV-1475708_31 1236976.JCM16418_5002 100.0 2.27e-25 NULL NULL NULL structural_annotation UHGV-1475708_31 TIGR02245 NULL NULL NULL NULL NULL KOfam UHGV-1475708_32 K01916 224.8 0 nadE; NAD+ synthase [EC:6.3.1.5] nadE; NAD+ synthase [EC:6.3.1.5] NULL PHROG UHGV-1475708_32 phrog_11189 164.6 0 NAD synthetase NAD synthetase other UniRef90 UHGV-1475708_32 UniRef90_A0A1T5BSP9 215.0 0 NH(3)-dependent NAD(+) synthetase NH(3)-dependent NAD(+) synthetase NULL eggNOG-mapper UHGV-1475708_32 1408321.JNJD01000006_gene1221 202.0 0 NAD synthase NAD synthase NULL Pfam UHGV-1475708_32 PF02540 NULL NULL NAD synthase NAD synthase NAD_synthase NCBIFam UHGV-1475708_32 TIGR00552.1 NULL NULL nadE/nadE/NAD(+) synthase/6.3.1.5 NAD(+) synthase NULL COG UHGV-1475708_32 COG0171 NULL NULL NH3-dependent NAD+ synthetase NH3-dependent NAD+ synthetase NULL eggNOG-mapper UHGV-1475708_34 1218103.CIN01S_02_01710 172.0 3.01279e-43 NULL NULL NULL structural_annotation UHGV-1475708_34 NF041916 NULL NULL NULL NULL NULL eggNOG-mapper UHGV-1475708_36 1151061.CAJY01000016_gene441 49.7 0.00000999 NULL NULL NULL Pfam UHGV-1475708_38 PF00684 NULL NULL DnaJ central domain DnaJ central domain DnaJ_CXXCXGXG Pfam UHGV-1475708_38 PF21002 NULL NULL Transmembrane protein 106 N-terminal region Transmembrane protein 106 N-terminal region TMEM106_N COG UHGV-1475708_38 COG0484 NULL NULL DnaJ-class molecular chaperone with C-terminal Zn finger domain DnaJ-class molecular chaperone with C-terminal Zn finger domain NULL PHROG UHGV-1475708_40 phrog_1174 40.3 0.000000000033 NULL NULL unknown function KOfam UHGV-1475708_43 K10747 76.9 1.4e-22 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7] NULL PHROG UHGV-1475708_43 phrog_114 91.1 6.4e-27 ATP-dependent DNA ligase ATP-dependent DNA ligase DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_43 UniRef90_A0A1R0WCG8 106.0 3.45e-22 DNA_LIGASE_A3 domain-containing protein DNA_LIGASE_A3 domain-containing protein NULL eggNOG-mapper UHGV-1475708_43 1121121.KB894295_gene4492 97.1 1.17e-19 dna ligase dna ligase NULL Pfam UHGV-1475708_43 PF04679 NULL NULL ATP dependent DNA ligase C terminal region ATP dependent DNA ligase C terminal region DNA_ligase_A_C COG UHGV-1475708_43 COG1793 NULL NULL ATP-dependent DNA ligase ATP-dependent DNA ligase NULL structural_annotation UHGV-1475708_43 PF01068,MF_00407,TIGR02779,COG1793 NULL NULL NULL NULL NULL KOfam UHGV-1475708_44 K01142 218.0 0 E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2] E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2] NULL PHROG UHGV-1475708_44 phrog_19169 109.0 1.9e-32 endonuclease endonuclease DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_44 UniRef90_A0A7V5BBS0 159.0 1.54143e-44 Exodeoxyribonuclease III Exodeoxyribonuclease III NULL eggNOG-mapper UHGV-1475708_44 1122216.AUHW01000022_gene1060 151.0 4.70976e-42 exodeoxyribonuclease III exodeoxyribonuclease III NULL Pfam UHGV-1475708_44 PF03372 NULL NULL Endonuclease/Exonuclease/phosphatase family Endonuclease/Exonuclease/phosphatase family Exo_endo_phos NCBIFam UHGV-1475708_44 TIGR00633.1 NULL NULL xth/exodeoxyribonuclease III exodeoxyribonuclease III NULL COG UHGV-1475708_44 COG0708 NULL NULL Exonuclease III Exonuclease III NULL structural_annotation UHGV-1475708_44 PF03372,MF_01119,NF010489,COG0708 NULL NULL NULL NULL NULL KOfam UHGV-1475708_45 K01520 78.5 8.8e-23 dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] NULL PHROG UHGV-1475708_45 phrog_135 87.1 1.5e-25 dUTPase dUTPase DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_45 UniRef90_A0A1H2SCA8 151.0 4.45613e-43 dUTP pyrophosphatase dUTP pyrophosphatase NULL eggNOG-mapper UHGV-1475708_45 1410612.JNKO01000001_gene2654 142.0 2.83001e-40 dUTP diphosphatase dUTP diphosphatase NULL Pfam UHGV-1475708_45 PF00692 NULL NULL dUTPase dUTPase dUTPase COG UHGV-1475708_45 COG0756 NULL NULL dUTP pyrophosphatase (dUTPase) dUTP pyrophosphatase (dUTPase) NULL KOfam UHGV-1475708_46 K01491 88.0 7.7e-26 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] NULL PHROG UHGV-1475708_46 phrog_7320 64.2 1.3e-18 tetrahydrofolate dehydrogenase and cyclohydrolase tetrahydrofolate dehydrogenase and cyclohydrolase other UniRef90 UHGV-1475708_46 UniRef90_A0A109QE37 81.6 0.0000000000000237 Bifunctional protein FolD Bifunctional protein FolD NULL eggNOG-mapper UHGV-1475708_46 946362.XP_004989928.1 57.4 0.00000225 formate-tetrahydrofolate ligase activity formate-tetrahydrofolate ligase activity NULL Pfam UHGV-1475708_46 PF00763 NULL NULL Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain THF_DHG_CYH Pfam UHGV-1475708_46 PF02882 NULL NULL Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH_C COG UHGV-1475708_46 COG2759 NULL NULL Formyltetrahydrofolate synthetase Formyltetrahydrofolate synthetase NULL structural_annotation UHGV-1475708_46 PF02882,PF00763,MF_01576,NF010775,COG0190 NULL NULL NULL NULL NULL eggNOG-mapper UHGV-1475708_52 1469948.JPNB01000001_gene1360 271.0 0 S-layer homology domain S-layer homology domain NULL Pfam UHGV-1475708_52 PF13927 NULL NULL Immunoglobulin domain Immunoglobulin domain Ig_3 Pfam UHGV-1475708_52 PF02368 NULL NULL Bacterial Ig-like domain (group 2) Bacterial Ig-like domain (group 2) Big_2 COG UHGV-1475708_52 COG2247 NULL NULL Putative cell wall-binding domain (amidase enhancer), LytB superfamily Putative cell wall-binding domain (amidase enhancer), LytB superfamily NULL eggNOG-mapper UHGV-1475708_53 1308866.J416_13124 60.5 0.000000146 domain protein domain protein NULL Pfam UHGV-1475708_53 PF05738 NULL NULL Cna protein B-type domain Cna protein B-type domain Cna_B COG UHGV-1475708_53 COG4932 NULL NULL Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold Clumping factor A-related surface protein, MSCRAMM (microbial surface components recognizing adhesive matrix molecules) family, DEv-IgG fold NULL eggNOG-mapper UHGV-1475708_55 1203606.HMPREF1526_00254 103.0 1.77e-26 NULL NULL NULL PHROG UHGV-1475708_56 phrog_1299 51.1 0.000000000000017 holin holin lysis UniRef90 UHGV-1475708_56 UniRef90_A0A1M5Z8P9 56.2 0.0000000721 Phage holin family Hol44, holin superfamily V Phage holin family Hol44, holin superfamily V NULL eggNOG-mapper UHGV-1475708_56 411473.RUMCAL_01944 50.4 0.00000205 Phage holin family Hol44, in holin superfamily V Phage holin family Hol44, in holin superfamily V NULL Pfam UHGV-1475708_56 PF16079 NULL NULL Phage holin family Hol44, in holin superfamily V Phage holin family Hol44, in holin superfamily V Phage_holin_5_2 KOfam UHGV-1475708_58 K07175 132.7 2.5e-39 phoH2; PhoH-like ATPase phoH2; PhoH-like ATPase NULL PHROG UHGV-1475708_58 phrog_2765 172.0 0 PhoH-like phosphate starvation-inducible PhoH-like phosphate starvation-inducible other UniRef90 UHGV-1475708_58 UniRef90_A0A416FDT9 223.0 0 PhoH domain-containing protein PhoH domain-containing protein NULL eggNOG-mapper UHGV-1475708_58 1123252.ATZF01000010_gene420 201.0 0 PIN domain PIN domain NULL Pfam UHGV-1475708_58 PF02562 NULL NULL PhoH-like protein PhoH-like protein PhoH COG UHGV-1475708_58 COG1875 NULL NULL Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains NULL structural_annotation UHGV-1475708_58 PF02562,MF_01920,NF007827,COG1875 NULL NULL NULL NULL NULL Pfam UHGV-1475708_59 PF01464 NULL NULL Transglycosylase SLT domain Transglycosylase SLT domain SLT structural_annotation UHGV-1475708_59 PF01464,MF_01616,NF011856,COG0741 NULL NULL NULL NULL NULL PHROG UHGV-1475708_60 phrog_1794 108.4 9.3e-32 amidase amidase lysis UniRef90 UHGV-1475708_60 UniRef90_A0A3A8WB60 170.0 0 N-acetylmuramoyl-L-alanine amidase N-acetylmuramoyl-L-alanine amidase NULL eggNOG-mapper UHGV-1475708_60 411468.CLOSCI_00531 157.0 1.21997e-41 n-acetylmuramoyl-l-alanine amidase n-acetylmuramoyl-l-alanine amidase NULL Pfam UHGV-1475708_60 PF01510 NULL NULL N-acetylmuramoyl-L-alanine amidase N-acetylmuramoyl-L-alanine amidase Amidase_2 COG UHGV-1475708_60 COG1705 NULL NULL Flagellum-specific peptidoglycan hydrolase FlgJ Flagellum-specific peptidoglycan hydrolase FlgJ NULL KOfam UHGV-1475708_63 K06871 81.4 1.2e-23 K06871; uncharacterized protein NULL NULL PHROG UHGV-1475708_63 phrog_1802 48.1 0.00000000000007 radical SAM domain-containing protein radical SAM domain-containing protein other eggNOG-mapper UHGV-1475708_63 411459.RUMOBE_00367 63.9 0.0000000243 Radical SAM Radical SAM NULL PADLOC UHGV-1475708_63 pVip-lone 54.8 0.000000000000002 Viperins not associated with kinases Viperins not associated with kinases Viperin Pfam UHGV-1475708_63 PF04055 NULL NULL Radical SAM superfamily Radical SAM superfamily Radical_SAM COG UHGV-1475708_63 COG0641 NULL NULL Sulfatase maturation enzyme AslB, radical SAM superfamily Sulfatase maturation enzyme AslB, radical SAM superfamily NULL KOfam UHGV-1475708_64 K06871 160.8 0 K06871; uncharacterized protein NULL NULL PHROG UHGV-1475708_64 phrog_1802 80.2 2.3e-23 radical SAM domain-containing protein radical SAM domain-containing protein other UniRef90 UHGV-1475708_64 UniRef90_A0A353GUY5 101.0 3.29e-20 Radical SAM core domain-containing protein Radical SAM core domain-containing protein NULL eggNOG-mapper UHGV-1475708_64 443254.Marpi_0911 80.1 0.000000000000104 radical SAM radical SAM NULL PADLOC UHGV-1475708_64 pVip-lone 48.2 0.00000000000026 Viperins not associated with kinases Viperins not associated with kinases Viperin Pfam UHGV-1475708_64 PF04055 NULL NULL Radical SAM superfamily Radical SAM superfamily Radical_SAM COG UHGV-1475708_64 COG0641 NULL NULL Sulfatase maturation enzyme AslB, radical SAM superfamily Sulfatase maturation enzyme AslB, radical SAM superfamily NULL KOfam UHGV-1475708_65 K06871 123.6 1.9e-36 K06871; uncharacterized protein NULL NULL PHROG UHGV-1475708_65 phrog_1802 64.9 7.4e-19 radical SAM domain-containing protein radical SAM domain-containing protein other UniRef90 UHGV-1475708_65 UniRef90_A0A7J4UHW0 71.6 0.000000000253 TIGR04084 family radical SAM/SPASM domain-containing protein TIGR04084 family radical SAM/SPASM domain-containing protein NULL eggNOG-mapper UHGV-1475708_65 489653.NLA_11150 60.8 0.00000016 4Fe-4S single cluster domain 4Fe-4S single cluster domain NULL PADLOC UHGV-1475708_65 pVip-lone 52.7 0.000000000000012 Viperins not associated with kinases Viperins not associated with kinases Viperin Pfam UHGV-1475708_65 PF04055 NULL NULL Radical SAM superfamily Radical SAM superfamily Radical_SAM COG UHGV-1475708_65 COG0641 NULL NULL Sulfatase maturation enzyme AslB, radical SAM superfamily Sulfatase maturation enzyme AslB, radical SAM superfamily NULL KOfam UHGV-1475708_67 K06871 48.2 0.00000000000014 K06871; uncharacterized protein NULL NULL eggNOG-mapper UHGV-1475708_67 862517.HMPREF9225_1629 60.5 0.0000000254 Six-Cys-in-45 modification radical SAM protein Six-Cys-in-45 modification radical SAM protein NULL NCBIFam UHGV-1475708_67 TIGR04085.1 NULL NULL rSAM_more_4Fe4S/SPASM domain-containing protein SPASM domain-containing protein NULL COG UHGV-1475708_67 COG0641 NULL NULL Sulfatase maturation enzyme AslB, radical SAM superfamily Sulfatase maturation enzyme AslB, radical SAM superfamily NULL KOfam UHGV-1475708_69 K02622 303.0 0 parE; topoisomerase IV subunit B [EC:5.6.2.2] parE; topoisomerase IV subunit B [EC:5.6.2.2] NULL PHROG UHGV-1475708_69 phrog_543 350.3 0 DNA topoisomerase II large subunit DNA topoisomerase II large subunit DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_69 UniRef90_A0A137SVW9 206.0 0 DNA gyrase subunit B DNA gyrase subunit B NULL eggNOG-mapper UHGV-1475708_69 342451.SSP1404 194.0 0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule NULL Pfam UHGV-1475708_69 PF02518 NULL NULL Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c Pfam UHGV-1475708_69 PF00204 NULL NULL DNA gyrase B DNA gyrase B DNA_gyraseB Pfam UHGV-1475708_69 PF01751 NULL NULL Toprim domain Toprim domain Toprim COG UHGV-1475708_69 COG0187 NULL NULL DNA gyrase/topoisomerase IV, subunit B DNA gyrase/topoisomerase IV, subunit B NULL structural_annotation UHGV-1475708_69 PF00204,MF_01898,TIGR01059,COG0187 NULL NULL NULL NULL NULL KOfam UHGV-1475708_70 K02621 344.6 0 parC; topoisomerase IV subunit A [EC:5.6.2.2] parC; topoisomerase IV subunit A [EC:5.6.2.2] NULL PHROG UHGV-1475708_70 phrog_551 279.8 0 DNA topoisomerase II DNA topoisomerase II DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_70 UniRef90_A0A843GJC9 298.0 0 DNA topoisomerase (ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing) NULL eggNOG-mapper UHGV-1475708_70 457415.HMPREF1006_01650 238.0 0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner NULL Pfam UHGV-1475708_70 PF00521 NULL NULL DNA gyrase/topoisomerase IV, subunit A DNA gyrase/topoisomerase IV, subunit A DNA_topoisoIV COG UHGV-1475708_70 COG0188 NULL NULL DNA gyrase/topoisomerase IV, subunit A DNA gyrase/topoisomerase IV, subunit A NULL PHROG UHGV-1475708_71 phrog_7168 63.3 4.5e-18 homing endonuclease homing endonuclease DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_71 UniRef90_A0A345BPZ2 135.0 1.12e-33 GIY-YIG domain-containing protein GIY-YIG domain-containing protein NULL eggNOG-mapper UHGV-1475708_71 1427984.X271_00109 61.6 0.0000000207 NULL NULL NULL PADLOC UHGV-1475708_71 HEase_00030 40.6 0.000000000068 homing endonuclease homing endonuclease RM Pfam UHGV-1475708_71 PF01541 NULL NULL GIY-YIG catalytic domain GIY-YIG catalytic domain GIY-YIG NCBIFam UHGV-1475708_71 TIGR01453.1 NULL NULL grpIintron_endo/group I intron endonuclease group I intron endonuclease NULL KOfam UHGV-1475708_73 K21636 430.0 0 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] NULL PHROG UHGV-1475708_73 phrog_487 520.4 0 NrdD-like anaerobic ribonucleotide reductase large subunit NrdD-like anaerobic ribonucleotide reductase large subunit moron, auxiliary metabolic gene and host takeover UniRef90 UHGV-1475708_73 UniRef90_A0A843FN11 619.0 0 Anaerobic ribonucleoside-triphosphate reductase Anaerobic ribonucleoside-triphosphate reductase NULL eggNOG-mapper UHGV-1475708_73 318464.IO99_02935 507.0 0 Ribonucleoside-triphosphate reductase Ribonucleoside-triphosphate reductase NULL Pfam UHGV-1475708_73 PF03477 NULL NULL ATP cone domain ATP cone domain ATP-cone Pfam UHGV-1475708_73 PF13597 NULL NULL Anaerobic ribonucleoside-triphosphate reductase Anaerobic ribonucleoside-triphosphate reductase NRDD NCBIFam UHGV-1475708_73 TIGR02487.1 NULL NULL NrdD/nrdD/anaerobic ribonucleoside-triphosphate reductase/1.17.4.2 anaerobic ribonucleoside-triphosphate reductase NULL COG UHGV-1475708_73 COG1328 NULL NULL Anaerobic ribonucleoside-triphosphate reductase Anaerobic ribonucleoside-triphosphate reductase NULL structural_annotation UHGV-1475708_73 PF13597,PF03477,MF_00440,NF005497,COG1328 NULL NULL NULL NULL NULL KOfam UHGV-1475708_74 K01358 83.9 2.4e-24 clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] NULL PHROG UHGV-1475708_74 phrog_94 85.4 8.3e-25 head maturation protease head maturation protease head and packaging UniRef90 UHGV-1475708_74 UniRef90_UPI000693817A 91.7 1.09e-19 ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit NULL eggNOG-mapper UHGV-1475708_74 180332.JTGN01000023_gene1608 91.7 1.83e-20 Clp protease Clp protease NULL Pfam UHGV-1475708_74 PF00574 NULL NULL Clp protease Clp protease CLP_protease COG UHGV-1475708_74 COG0740 NULL NULL ATP-dependent protease ClpP, protease subunit ATP-dependent protease ClpP, protease subunit NULL structural_annotation UHGV-1475708_74 PF00574,MF_00444,NF009205,COG0740 NULL NULL NULL NULL NULL KOfam UHGV-1475708_76 K03465 214.4 0 thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] NULL PHROG UHGV-1475708_76 phrog_85 154.5 0 thymidylate synthase thymidylate synthase DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_76 UniRef90_A0A2A7B932 268.0 0 Thymidylate synthase (FAD) Thymidylate synthase (FAD) NULL eggNOG-mapper UHGV-1475708_76 933262.AXAM01000172_gene933 248.0 0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant NULL Pfam UHGV-1475708_76 PF02511 NULL NULL Thymidylate synthase complementing protein Thymidylate synthase complementing protein Thy1 NCBIFam UHGV-1475708_76 TIGR02170.1 NULL NULL thyX/thyX/FAD-dependent thymidylate synthase/2.1.1.148 FAD-dependent thymidylate synthase NULL COG UHGV-1475708_76 COG1351 NULL NULL Thymidylate synthase ThyX, FAD-dependent family Thymidylate synthase ThyX, FAD-dependent family NULL HAMAP UHGV-1475708_76 MF_01408 NULL NULL Flavin-dependent thymidylate synthase [thyX] Flavin-dependent thymidylate synthase [thyX] NULL structural_annotation UHGV-1475708_76 PF02511,MF_01408,TIGR02170,COG1351 NULL NULL NULL NULL NULL eggNOG-mapper UHGV-1475708_77 871968.DESME_08990 58.5 0.00000000341 NULL NULL NULL KOfam UHGV-1475708_78 K07462 218.4 0 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] NULL PHROG UHGV-1475708_78 phrog_2484 344.3 0 RecJ-like ssDNA exonuclease RecJ-like ssDNA exonuclease DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_78 UniRef90_A0A843GQK3 278.0 0 DHH family phosphoesterase DHH family phosphoesterase NULL eggNOG-mapper UHGV-1475708_78 665956.HMPREF1032_03163 224.0 0 exonuclease exonuclease NULL Pfam UHGV-1475708_78 PF01368 NULL NULL DHH family DHH family DHH Pfam UHGV-1475708_78 PF17768 NULL NULL RecJ OB domain RecJ OB domain RecJ_OB COG UHGV-1475708_78 COG0608 NULL NULL ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation ssDNA-specific exonuclease RecJ, DHH superfamily, may be involved in archaeal DNA replication intiation NULL structural_annotation UHGV-1475708_78 PF17768,PF02272,MF_00207,TIGR00644,COG0608 NULL NULL NULL NULL NULL PHROG UHGV-1475708_79 phrog_124 92.7 3.6e-27 Sak4-like ssDNA annealing protein Sak4-like ssDNA annealing protein DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_79 UniRef90_A0A843GNA1 95.1 9.6e-19 ATP-binding protein ATP-binding protein NULL eggNOG-mapper UHGV-1475708_79 1541960.KQ78_01919 84.7 7.3e-16 Belongs to the helicase family. UvrD subfamily Belongs to the helicase family. UvrD subfamily NULL Pfam UHGV-1475708_79 PF13479 NULL NULL AAA domain AAA domain AAA_24 COG UHGV-1475708_79 COG2887 NULL NULL RecB family exonuclease RecB family exonuclease NULL structural_annotation UHGV-1475708_79 PF13479,MF_00350,TIGR01618,COG0468 NULL NULL NULL NULL NULL structural_annotation UHGV-1475708_80 PF00436,PF19649,MF_00984,NF004476,COG2965 NULL NULL NULL NULL NULL KOfam UHGV-1475708_81 K02316 58.3 9.6e-17 dnaG; DNA primase [EC:2.7.7.101] dnaG; DNA primase [EC:2.7.7.101] NULL PHROG UHGV-1475708_81 phrog_47 56.5 3.5e-16 DNA primase DNA primase DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_81 UniRef90_A0A1C6AU17 295.0 0 DNA primase (Bacterial type) DNA primase (Bacterial type) NULL eggNOG-mapper UHGV-1475708_81 537007.BLAHAN_05496 75.1 0.00000000000723 DNA primase activity DNA primase activity NULL COG UHGV-1475708_81 COG0358 NULL NULL DNA primase (bacterial type) DNA primase (bacterial type) NULL KOfam UHGV-1475708_82 K03581 85.8 1.90001e-40 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] NULL PHROG UHGV-1475708_82 phrog_325 148.4 1.96182e-44 Dda-like helicase Dda-like helicase DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_82 UniRef90_R5G5Y5 71.2 0.00000000187 Exodeoxyribonuclease V Exodeoxyribonuclease V NULL eggNOG-mapper UHGV-1475708_82 1219077.VAZ01S_010_00750 65.9 0.0000000168 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD NULL Pfam UHGV-1475708_82 PF13245 NULL NULL AAA domain AAA domain AAA_19 Pfam UHGV-1475708_82 PF01443 NULL NULL Viral (Superfamily 1) RNA helicase Viral (Superfamily 1) RNA helicase Viral_helicase1 COG UHGV-1475708_82 COG0507 NULL NULL ATPase/5'-3' helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ATPase/5'-3' helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) NULL structural_annotation UHGV-1475708_82 PF13604,MF_01488,TIGR01448,COG0507 NULL NULL NULL NULL NULL KOfam UHGV-1475708_83 K02337 581.6 0 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] NULL PHROG UHGV-1475708_83 phrog_405 671.3 0 DNA polymerase DNA polymerase DNA, RNA and nucleotide metabolism UniRef90 UHGV-1475708_83 UniRef90_A0A843FMN7 854.0 0 DNA-directed DNA polymerase DNA-directed DNA polymerase NULL eggNOG-mapper UHGV-1475708_83 224308.BSU20340 651.0 0 DNA polymerase DNA polymerase NULL Pfam UHGV-1475708_83 PF02811 NULL NULL PHP domain PHP domain PHP Pfam UHGV-1475708_83 PF07733 NULL NULL Bacterial DNA polymerase III alpha NTPase domain Bacterial DNA polymerase III alpha NTPase domain DNA_pol3_alpha Pfam UHGV-1475708_83 PF17657 NULL NULL Bacterial DNA polymerase III alpha subunit finger domain Bacterial DNA polymerase III alpha subunit finger domain DNA_pol3_finger Pfam UHGV-1475708_83 PF14579 NULL NULL Helix-hairpin-helix motif Helix-hairpin-helix motif HHH_6 COG UHGV-1475708_83 COG0587 NULL NULL DNA polymerase III, alpha subunit DNA polymerase III, alpha subunit NULL structural_annotation UHGV-1475708_83 PF07733,PF02811,PF17657,PF14579,MF_01902,NF005617,COG0587 NULL NULL NULL NULL NULL PHROG UHGV-1475708_84 phrog_236 104.9 1.3e-30 nucleotide kinase nucleotide kinase other UniRef90 UHGV-1475708_84 UniRef90_A0A418MBD6 95.9 6.04e-24 DUF3310 domain-containing protein NULL NULL eggNOG-mapper UHGV-1475708_84 546273.VEIDISOL_00707 78.6 6.94e-17 Protein of unknwon function (DUF3310) NULL NULL Pfam UHGV-1475708_84 PF11753 NULL NULL Protein of unknwon function (DUF3310) NULL DUF3310 eggNOG-mapper UHGV-1475708_86 445970.ALIPUT_02794 151.0 6.16e-37 domain, Protein domain, Protein NULL COG UHGV-1475708_86 COG5492 NULL NULL Uncharacterized conserved protein YjdB, contains Ig-like domain NULL NULL PHROG UHGV-1475708_87 phrog_2729 69.7 3.3e-37 virion structural protein virion structural protein head and packaging eggNOG-mapper UHGV-1475708_87 1560313.A0A0D3MTD7_9CAUD 74.7 0.00000000000289 NULL NULL NULL PHROG UHGV-1475708_88 phrog_4051 106.3 2.8e-31 NULL NULL unknown function PHROG UHGV-1475708_89 phrog_6123 61.9 4.4e-18 virion structural protein virion structural protein head and packaging structural_annotation UHGV-1475708_89 PF06141 NULL NULL NULL NULL NULL PHROG UHGV-1475708_90 phrog_31155 50.3 0.000000000000032 NULL NULL unknown function UniRef90 UHGV-1475708_90 UniRef90_A0A345BPV9 107.0 2.8e-23 Ig domain protein Ig domain protein NULL structural_annotation UHGV-1475708_90 PF19408,PF11649,NF041894,COG5614 NULL NULL NULL NULL NULL PHROG UHGV-1475708_91 phrog_29637 46.0 0.00000000000076 NULL NULL unknown function PHROG UHGV-1475708_92 phrog_3853 66.9 2.4e-19 NULL NULL unknown function PHROG UHGV-1475708_94 phrog_4088 225.5 0 NULL NULL unknown function eggNOG-mapper UHGV-1475708_94 1541960.KQ78_01850 225.0 0 NULL NULL NULL structural_annotation UHGV-1475708_94 PF05065,MF_04119,TIGR01554,COG4653 NULL NULL NULL NULL NULL PHROG UHGV-1475708_96 phrog_3313 105.8 5.5e-36 NULL NULL unknown function eggNOG-mapper UHGV-1475708_96 1308863.U5J9D4_9CAUD 81.6 0.000000000000178 NULL NULL NULL PHROG UHGV-1475708_97 phrog_32343 73.7 2.6e-26 NULL NULL unknown function UniRef90 UHGV-1475708_97 UniRef90_A0A345BPW9 335.0 0 Putative flagellin-like protein Putative flagellin-like protein NULL structural_annotation UHGV-1475708_97 PF06605,COG4379 NULL NULL NULL NULL NULL PHROG UHGV-1475708_98 phrog_30026 44.1 2.1e-19 NULL NULL unknown function UniRef90 UHGV-1475708_98 UniRef90_A0A3S0R0B2 78.2 0.000000000188 Autotransporter domain-containing protein Autotransporter domain-containing protein NULL eggNOG-mapper UHGV-1475708_98 1408813.AYMG01000014_gene1651 87.0 0.0000000000000724 C-terminal domain of CHU protein family C-terminal domain of CHU protein family NULL Pfam UHGV-1475708_98 PF05345 NULL NULL Putative Ig domain Putative Ig domain He_PIG COG UHGV-1475708_98 COG1361 NULL NULL S-layer protein MJ0795, predicted component of type IV pili-like system S-layer protein MJ0795, predicted component of type IV pili-like system NULL structural_annotation UHGV-1475708_99 PF07761 NULL NULL NULL NULL NULL PHROG UHGV-1475708_100 phrog_2739 229.6 0 portal protein portal protein head and packaging UniRef90 UHGV-1475708_100 UniRef90_A0A345BPV2 326.0 0 Putative portal protein Putative portal protein NULL eggNOG-mapper UHGV-1475708_100 665956.HMPREF1032_03237 101.0 7.5e-20 NULL NULL NULL PHROG UHGV-1475708_101 phrog_9084 72.3 7.3e-21 homing endonuclease homing endonuclease DNA, RNA and nucleotide metabolism eggNOG-mapper UHGV-1475708_101 397291.C804_06294 72.8 0.000000000000287 transposase activity transposase activity NULL COG UHGV-1475708_101 COG2963 NULL NULL Transposase InsE and inactivated derivatives Transposase InsE and inactivated derivatives NULL structural_annotation UHGV-1475708_101 PF18741,MF_04160,NF007294,COG2852 NULL NULL NULL NULL NULL PHROG UHGV-1475708_102 phrog_24618 168.9 0 NULL NULL unknown function UniRef90 UHGV-1475708_102 UniRef90_A0A0H3V0N0 360.0 0 Putative terminase large subunit Putative terminase large subunit NULL eggNOG-mapper UHGV-1475708_102 1235793.C809_01156 197.0 0 NULL NULL NULL Pfam UHGV-1475708_102 PF17289 NULL NULL Terminase RNaseH-like domain Terminase RNaseH-like domain Terminase_6C structural_annotation UHGV-1475708_102 PF20441,PF04466,MF_04146,TIGR01547,COG4626 NULL NULL NULL NULL NULL PHROG UHGV-1475708_103 phrog_3314 190.0 0 NULL NULL unknown function eggNOG-mapper UHGV-1475708_103 1308863.U5J9N3_9CAUD 79.7 0.0000000000000736 NULL NULL NULL PHROG UHGV-1475708_106 phrog_4211 122.7 1.70006e-41 tail length tape measure protein tail length tape measure protein tail eggNOG-mapper UHGV-1475708_106 1234664.AMRO01000024_gene1817 63.9 0.00000119 Phage tail tape measure protein, TP901 family Phage tail tape measure protein, TP901 family NULL Pfam UHGV-1475708_106 PF10145 NULL NULL Phage-related minor tail protein Phage-related minor tail protein PhageMin_Tail NCBIFam UHGV-1475708_106 TIGR01760.1 NULL NULL tape_meas_TP901/phage tail tape measure protein phage tail tape measure protein NULL COG UHGV-1475708_106 COG5283 NULL NULL Phage-related tail protein Phage-related tail protein NULL