gene_oid	gene_length	percent_identity	query_start	query_end	subj_start	subj_end	evalue	bit_score	cog_id	cog_name	cog_length
646447363	462	56.73	6	458	1	408	0.0e+00	512	COG0593	Chromosomal replication initiation ATPase DnaA	408
646447364	366	44.14	1	366	1	364	5.0e-108	384	COG0592	DNA polymerase III sliding clamp (beta) subunit, PCNA homolog	364
646447365	361	42.98	1	356	1	362	3.0e-107	382	COG1195	Recombinational DNA repair ATPase RecF	363
646447366	803	64.87	1	556	2	555	0.0e+00	927	COG0187	DNA gyrase/topoisomerase IV, subunit B	635
646447367	394	21.24	24	391	30	394	1.0e-12	68.3	COG2814	Predicted arabinose efflux permease, MFS family	394
646447369	680	60.94	1	680	8	683	0.0e+00	995	COG0339	Zn-dependent oligopeptidase	683
646447371	280	65.23	2	280	1	279	4.0e-122	430	COG2961	23S rRNA A2030 N6-methylase RlmJ	279
646447372	304	49.18	1	304	2	291	4.0e-80	291	COG1234	Ribonuclease BN, tRNA processing enzyme	292
646447373	529	63.47	1	528	1	530	0.0e+00	735	COG4650	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain	531
646447375	407	37.47	14	407	6	432	2.0e-119	422	COG1690	RNA-splicing ligase RtcB, repairs tRNA damage	432
646447376	450	39.39	1	450	1	454	1.0e-124	440	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
646447377	473	31.78	7	472	1	461	6.0e-45	175	COG0471	Di- and tricarboxylate transporter	461
646447378	450	42.17	15	445	5	438	2.0e-123	436	COG0015	Adenylosuccinate lyase	438
646447379	244	29.61	1	232	4	231	6.0e-35	141	COG2188	DNA-binding transcriptional regulator, GntR family	236
646447380	344	23.28	14	304	1	287	3.0e-25	109	COG0657	Acetyl esterase/lipase	312
646447382	156	37.5	1	152	4	154	9.0e-33	132	COG1522	DNA-binding transcriptional regulator, Lrp family	154
646447383	373	27.06	8	367	1	362	2.0e-54	206	COG1932	Phosphoserine aminotransferase	365
646447384	386	32.84	19	354	13	339	3.0e-63	235	COG1509	L-lysine 2,3-aminomutase (EF-P beta-lysylation pathway)	369
646447386	242	19.29	40	235	29	216	1.0e-11	63.5	COG4340	Uncharacterized protein	226
646447389	146	34.48	23	138	8	123	8.0e-10	56.5	COG1846	DNA-binding transcriptional regulator, MarR family	126
646447391	322	56.78	1	317	4	320	1.0e-119	423	COG0837	Glucokinase	320
646447393	374	29.81	15	162	28	188	1.0e-17	84.7	COG4950	N-terminal domain of uncharacterized protein YciW (function unknown)	193
646447394	346	28.32	13	326	6	334	8.0e-32	131	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
646447395	547	50.47	11	542	1	535	0.0e+00	596	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
646447396	286	45.13	9	283	4	280	2.0e-56	213	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646447397	313	43.4	3	310	2	316	9.0e-61	227	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646447398	547	24.64	15	547	17	554	1.0e-64	241	COG0747	ABC-type transport system, periplasmic component	556
646447400	418	77.88	1	416	1	416	0.0e+00	725	COG3977	Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase	417
646447402	320	44.75	1	316	1	323	2.0e-94	339	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
646447403	151	21.13	1	125	13	154	8.0e-07	46.5	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
646447404	186	60.54	1	184	1	185	9.0e-82	296	COG2818	3-methyladenine DNA glycosylase Tag	188
646447405	268	29	1	262	2	251	5.0e-10	58.5	COG0730	Uncharacterized membrane protein YfcA	258
646447406	304	81	3	302	1	298	0.0e+00	574	COG0752	Glycyl-tRNA synthetase, alpha subunit	298
646447407	689	56.58	1	689	1	690	0.0e+00	941	COG0751	Glycyl-tRNA synthetase, beta subunit	691
646447409	369	50.14	1	353	1	335	7.0e-122	430	COG3839	ABC-type sugar transport system, ATPase component	338
646447410	399	28.85	77	379	1	309	1.0e-39	157	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646447411	373	32.14	64	359	3	308	3.0e-42	166	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646447413	414	21.94	1	408	4	428	1.0e-27	117	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
646447414	315	44.22	23	315	5	291	1.0e-56	213	COG1175	ABC-type sugar transport system, permease component	295
646447415	272	42.91	9	271	14	281	3.0e-58	218	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
646447416	1197	38.99	1	562	1	566	0.0e+00	534	COG4770	Acetyl/propionyl-CoA carboxylase, alpha subunit	645
646447417	211	36.54	10	211	43	247	1.0e-44	172	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	264
646447418	246	28.36	16	209	51	245	1.0e-23	103	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	264
646447419	259	43.1	1	239	1	223	1.0e-64	239	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
646447420	270	33.2	12	270	9	257	1.0e-33	136	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	258
646447421	351	25.08	1	319	5	320	2.0e-27	116	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	335
646447423	635	75.11	1	467	1	470	0.0e+00	743	COG2213	Phosphotransferase system, mannitol-specific IIBC component	472
646447424	383	32.66	3	383	17	455	6.0e-89	321	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
646447425	203	68.75	28	203	1	173	9.0e-61	226	COG3722	DNA-binding transcriptional regulator, MltR family	174
646447426	628	36.41	238	602	19	408	5.0e-52	199	COG0840	Methyl-accepting chemotaxis protein	408
646447427	208	62.74	1	208	2	203	2.0e-77	282	COG0605	Superoxide dismutase	204
646447428	272	52.19	22	270	15	264	7.0e-84	303	COG1526	Formate dehydrogenase assembly factor FdhD	266
646447429	511	44.47	24	506	1	472	0.0e+00	511	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646447430	305	33.33	1	304	9	311	7.0e-50	191	COG4977	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain	328
646447431	186	25.25	1	168	3	200	3.0e-18	84.9	COG1335	Nicotinamidase-related amidase	205
646447432	486	44.24	1	486	5	499	0.0e+00	461	COG1070	Sugar (pentulose or hexulose) kinase	502
646447433	439	77.12	1	437	2	438	0.0e+00	772	COG2115	Xylose isomerase	438
646447434	331	65.19	1	331	1	339	1.0e-119	423	COG4213	ABC-type xylose transport system, periplasmic component	341
646447435	513	51.68	1	504	5	500	0.0e+00	618	COG1129	ABC-type sugar transport system, ATPase component	500
646447436	394	57.67	22	394	17	394	3.0e-119	421	COG4214	ABC-type xylose transport system, permease component	394
646447437	424	24.25	18	278	72	329	3.0e-32	132	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646447438	190	34.81	1	167	2	182	1.0e-21	96.8	COG0693	Putative intracellular protease/amidase	188
646447439	92	46.15	1	91	1	89	3.0e-19	86.8	COG1937	DNA-binding transcriptional regulator, FrmR family	89
646447440	326	31.17	1	322	41	298	4.0e-53	202	COG2215	ABC-type nickel/cobalt efflux system, permease component RcnA	303
646447441	449	35.78	8	427	1	402	0.0e+00	468	COG0137	Argininosuccinate synthase	403
646447442	166	29.6	37	160	5	126	6.0e-10	57.2	COG1846	DNA-binding transcriptional regulator, MarR family	126
646447443	297	23.26	58	272	71	278	2.0e-07	49.9	COG5006	Threonine/homoserine efflux transporter RhtA	292
646447444	316	47.54	1	305	1	305	3.0e-92	332	COG2313	Pseudouridine-5'-phosphate glycosidase (pseudoU degradation)	310
646447445	230	39.44	1	213	3	214	6.0e-43	167	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
646447446	1488	30.37	27	654	18	642	4.0e-101	363	COG1020	Non-ribosomal peptide synthetase component F	642
646447450	451	19.86	19	438	16	442	8.0e-14	71.8	COG0534	Na+-driven multidrug efflux pump	455
646447452	187	35.64	44	144	22	121	3.0e-18	84.9	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646447453	235	48.42	4	222	1	220	8.0e-74	270	COG1136	ABC-type lipoprotein export system, ATPase component	226
646447454	813	19.55	22	405	16	417	7.0e-14	73.2	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
646447455	466	43.4	1	464	1	457	8.0e-127	447	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646447461	378	23.76	23	361	25	380	2.0e-22	100	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
646447462	307	22.08	13	305	14	320	2.0e-16	80.3	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
646447464	377	26.42	73	369	67	379	4.0e-33	135	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
646447466	515	23.66	1	495	9	524	6.0e-50	192	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646447467	522	24.9	27	519	36	534	8.0e-50	191	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646447469	527	30.49	7	519	13	533	5.0e-96	345	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646447471	446	32.06	25	414	12	394	7.0e-78	284	COG0019	Diaminopimelate decarboxylase	394
646447473	250	43.55	179	240	4	65	8.0e-11	61.2	COG2771	DNA-binding transcriptional regulator, CsgD family	65
646447474	212	34.72	1	191	1	193	1.0e-45	176	COG3916	N-acyl-L-homoserine lactone synthetase	209
646447476	287	56.9	1	287	1	290	5.0e-92	331	COG1561	Uncharacterized conserved protein YicC, UPF0701 family	290
646447477	302	24.41	1	294	1	297	2.0e-29	123	COG0583	DNA-binding transcriptional regulator, LysR family	297
646447478	360	40.41	18	360	2	313	3.0e-79	289	COG2355	Zn-dependent dipeptidase, microsomal dipeptidase homolog	313
646447479	531	26.75	1	525	11	547	1.0e-65	244	COG0747	ABC-type transport system, periplasmic component	556
646447480	336	45.23	11	335	9	313	1.0e-82	300	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646447481	300	51.99	26	300	11	287	6.0e-76	277	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646447482	276	54.1	2	265	1	268	1.0e-95	343	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
646447483	246	50.6	1	246	3	252	1.0e-83	302	COG1124	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	252
646447484	503	25	2	317	32	363	2.0e-21	97.3	COG1680	CubicO group peptidase, beta-lactamase class C family	390
646447488	234	48.18	10	228	2	220	3.0e-74	271	COG1136	ABC-type lipoprotein export system, ATPase component	226
646447489	406	23.68	29	406	2	419	2.0e-27	117	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
646447490	492	23.66	11	492	1	455	6.0e-30	125	COG1538	Outer membrane protein TolC	457
646447494	159	41.14	1	154	1	154	1.0e-32	132	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
646447495	321	52.98	1	319	2	307	6.0e-91	327	COG1446	Isoaspartyl peptidase or L-asparaginase, Ntn-hydrolase superfamily	307
646447496	273	42.59	1	269	1	268	4.0e-60	225	COG2362	D-aminopeptidase	274
646447497	351	38.9	20	346	1	347	1.0e-70	260	COG3191	L-aminopeptidase/D-esterase	348
646447498	300	50.53	21	300	8	288	6.0e-74	270	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646447499	306	49.68	1	306	1	316	1.0e-88	319	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646447500	519	31.44	13	513	23	547	1.0e-83	303	COG0747	ABC-type transport system, periplasmic component	556
646447501	630	54.37	21	581	4	539	0.0e+00	690	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
646447502	321	28.48	1	307	1	328	9.0e-41	161	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646447503	335	37.72	1	325	4	329	1.0e-66	247	COG3367	Uncharacterized conserved protein, NAD-dependent epimerase/dehydratase family	339
646447505	133	52.78	26	131	11	118	1.0e-20	91.9	COG2149	Uncharacterized membrane protein YidH, DUF202 family	120
646447506	238	57.98	1	237	8	230	6.0e-79	287	COG0689	Ribonuclease PH	230
646447507	213	40.09	3	211	1	201	2.0e-51	195	COG0461	Orotate phosphoribosyltransferase	201
646447508	198	26.82	1	179	3	178	1.0e-06	46.6	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646447509	152	51.66	2	152	1	148	3.0e-53	200	COG0756	dUTPase	148
646447510	418	51.76	14	410	1	392	7.0e-120	424	COG0452	Phosphopantothenoylcysteine synthetase/decarboxylase	392
646447512	221	51.17	9	221	12	224	1.0e-73	269	COG2003	DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif	224
646447513	78	66.23	1	76	1	77	8.0e-22	95.4	COG0227	Ribosomal protein L28	77
646447514	55	62	4	53	1	50	4.0e-10	56.4	COG0267	Ribosomal protein L33	50
646447515	269	57.88	1	269	1	273	3.0e-100	358	COG0266	Formamidopyrimidine-DNA glycosylase	273
646447516	159	61.01	1	159	1	159	1.0e-68	251	COG0669	Phosphopantetheine adenylyltransferase	159
646447517	263	21.97	2	252	1	261	6.0e-14	71.3	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646447518	427	55.58	4	422	1	419	0.0e+00	525	COG1519	3-deoxy-D-manno-octulosonic-acid transferase	419
646447519	374	25.33	6	371	3	380	1.0e-37	150	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646447520	369	27.24	30	318	1	310	7.0e-33	135	COG0859	ADP-heptose:LPS heptosyltransferase	334
646447521	402	18.1	36	350	50	374	3.0e-07	50.2	COG3307	O-antigen ligase	424
646447522	372	22.9	1	372	1	378	1.0e-29	124	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646447523	361	33.05	10	356	2	330	2.0e-52	200	COG0859	ADP-heptose:LPS heptosyltransferase	334
646447524	323	32.74	1	323	2	332	2.0e-67	249	COG0859	ADP-heptose:LPS heptosyltransferase	334
646447525	350	39	1	339	2	326	1.0e-76	280	COG0859	ADP-heptose:LPS heptosyltransferase	334
646447526	310	30.62	1	309	2	311	8.0e-49	187	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646447527	398	46.65	5	391	3	388	1.0e-123	436	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
646447528	342	34.28	1	340	1	350	4.0e-77	281	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
646447529	309	48.74	8	240	10	247	3.0e-72	265	COG2861	Uncharacterized conserved protein YibQ, putative polysaccharide deacetylase 2 family	250
646447530	424	48.43	13	424	10	420	2.0e-92	332	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	420
646447531	143	36.7	35	143	2	110	6.0e-17	80	COG0607	Rhodanese-related sulfurtransferase	110
646447532	157	60.67	3	152	5	154	1.0e-56	212	COG1952	Preprotein translocase subunit SecB	157
646447533	339	55.49	8	335	4	329	1.0e-122	433	COG0240	Glycerol-3-phosphate dehydrogenase	329
646447534	273	58.03	76	268	2	194	8.0e-71	260	COG1045	Serine acetyltransferase	194
646447536	299	23.18	1	282	9	292	3.0e-06	46	COG0697	Permease of the drug/metabolite transporter (DMT) superfamily	292
646447537	312	31	2	294	1	296	1.0e-33	137	COG0583	DNA-binding transcriptional regulator, LysR family	297
646447538	755	65.56	422	752	1	329	1.0e-129	457	COG0620	Methionine synthase II (cobalamin-independent)	330
646447539	275	42.39	36	273	1	234	1.0e-57	217	COG0412	Dienelactone hydrolase	236
646447540	253	61.35	1	251	3	248	9.0e-87	313	COG2820	Uridine phosphorylase	248
646447541	260	33.2	12	255	1	248	1.0e-35	143	COG2365	Protein tyrosine/serine phosphatase	249
646447543	879	58.38	2	879	3	910	0.0e+00	1213	COG2352	Phosphoenolpyruvate carboxylase	910
646447544	383	34.06	1	383	8	409	7.0e-68	251	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646447545	334	52.62	1	333	2	342	1.0e-124	439	COG0002	N-acetyl-gamma-glutamylphosphate reductase	349
646447546	257	42.42	1	256	2	264	2.0e-64	239	COG0548	Acetylglutamate kinase	265
646447547	457	57.11	1	457	3	458	0.0e+00	638	COG0165	Argininosuccinate lyase	459
646447548	514	41.74	50	497	7	448	2.0e-92	333	COG1322	DNA anti-recombination protein (rearrangement mutator) RmuC	448
646447549	251	60.42	13	251	1	238	8.0e-86	310	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
646447550	202	50.25	1	199	1	199	8.0e-48	183	COG3165	Ubiquinone biosynthesis protein UbiJ, contains SCP2 domain	204
646447551	545	46.36	1	517	2	517	0.0e+00	532	COG0661	Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family	517
646447552	84	32.53	1	83	1	81	2.0e-12	63.8	COG1826	Sec-independent protein translocase protein TatA	94
646447553	214	42.39	1	92	1	90	3.0e-15	75.4	COG1826	Sec-independent protein translocase protein TatA	94
646447554	256	53.54	1	251	2	255	3.0e-64	238	COG0805	Sec-independent protein secretion pathway component TatC	255
646447555	264	37.69	1	258	3	255	2.0e-68	252	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
646447556	340	60.98	9	336	5	330	0.0e+00	529	COG0113	Delta-aminolevulinic acid dehydratase, porphobilinogen synthase	330
646447557	162	25	1	162	2	177	4.0e-28	117	COG0250	Transcription antitermination factor NusG	178
646447558	498	58.69	4	492	1	477	0.0e+00	685	COG0043	3-polyprenyl-4-hydroxybenzoate decarboxylase	477
646447559	233	30.26	1	227	5	224	5.0e-42	164	COG0543	NAD(P)H-flavin reductase	252
646447560	387	46.78	1	387	1	392	8.0e-95	340	COG0183	Acetyl-CoA acetyltransferase	392
646447561	729	43.48	315	612	5	300	2.0e-91	330	COG1250	3-hydroxyacyl-CoA dehydrogenase	307
646447562	447	22.17	17	442	11	375	3.0e-37	150	COG0006	Xaa-Pro aminopeptidase	384
646447563	204	38.92	1	202	1	202	1.0e-48	186	COG1739	Putative translation regulator, IMPACT (imprinted ancient) protein family	203
646447564	483	49.6	1	483	1	488	3.0e-108	386	COG0168	Trk-type K+ transport system, membrane component	499
646447565	179	62.5	1	175	1	175	1.0e-61	229	COG4635	Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain)	175
646447571	345	35.44	6	337	7	291	1.0e-79	290	COG0812	UDP-N-acetylenolpyruvoylglucosamine reductase	291
646447572	319	43.93	84	319	1	238	4.0e-61	228	COG0340	Biotin-(acetyl-CoA carboxylase) ligase	238
646447573	316	60.49	10	295	4	283	1.0e-110	392	COG1072	Panthothenate kinase	283
646447578	394	87.31	1	394	1	394	0.0e+00	733	COG0050	Translation elongation factor EF-Tu, a GTPase	394
646447579	127	53.42	49	121	1	73	5.0e-12	63.5	COG0690	Preprotein translocase subunit SecE	73
646447580	181	54.86	6	180	2	176	8.0e-58	216	COG0250	Transcription antitermination factor NusG	178
646447581	142	71.63	2	142	1	140	2.0e-51	194	COG0080	Ribosomal protein L11	141
646447582	234	61.84	1	227	1	228	2.0e-81	295	COG0081	Ribosomal protein L1	228
646447583	165	46.63	1	162	1	162	1.0e-36	145	COG0244	Ribosomal protein L10	175
646447584	121	66.94	1	121	1	124	2.0e-22	98	COG0222	Ribosomal protein L7/L12	124
646447586	1407	52.61	20	853	7	808	0.0e+00	934	COG0086	DNA-directed RNA polymerase, beta' subunit/160 kD subunit	808
646447590	478	37.79	1	467	3	455	1.0e-102	367	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
646447591	255	34.84	24	255	2	244	4.0e-49	188	COG2041	Periplasmic DMSO/TMAO reductase YedYZ, molybdopterin-dependent catalytic subunit	271
646447592	200	39.69	8	196	22	215	4.0e-36	144	COG4117	Thiosulfate reductase cytochrome b subunit	221
646447594	223	45.61	1	221	1	227	4.0e-56	210	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646447595	477	33.02	165	475	31	336	4.0e-37	149	COG0642	Signal transduction histidine kinase	336
646447596	381	26.65	24	372	3	359	4.0e-79	288	COG1060	2-iminoacetate synthase ThiH (tyrosine cleavage enzyme, thamine biosynthesis)	370
646447597	259	66.14	1	253	7	260	2.0e-104	371	COG2022	Thiamin biosynthesis thiazole synthase ThiGH, ThiG subunit	262
646447598	66	39.39	1	66	3	68	9.0e-12	61.8	COG2104	Sulfur carrier protein ThiS (thiamine biosynthesis)	68
646447599	249	52.57	1	247	2	254	9.0e-68	250	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
646447600	211	43.78	11	211	14	211	5.0e-49	187	COG0352	Thiamine monophosphate synthase	211
646447601	653	69.13	159	616	1	432	0.0e+00	766	COG0422	Thiamine biosynthesis protein ThiC	432
646447602	257	50.76	1	254	10	271	2.0e-86	312	COG2816	NADH pyrophosphatase NudC, Nudix superfamily	279
646447603	357	56.66	1	352	2	352	0.0e+00	463	COG0407	Uroporphyrinogen-III decarboxylase	352
646447604	224	48.37	1	213	2	212	2.0e-66	245	COG1515	Deoxyinosine 3'endonuclease (endonuclease V)	212
646447605	196	83.51	1	194	1	194	4.0e-91	326	COG3068	Uncharacterized protein YjaG, DUF416 family	194
646447606	90	60	1	90	2	91	3.0e-27	113	COG0776	Bacterial nucleoid DNA-binding protein	94
646447608	429	62.47	1	427	1	427	0.0e+00	641	COG0151	Phosphoribosylamine-glycine ligase	428
646447609	529	66.1	6	529	1	515	0.0e+00	810	COG0138	AICAR transformylase/IMP cyclohydrolase PurH	515
646447615	253	62.08	13	252	2	240	7.0e-118	416	COG1126	ABC-type polar amino acid transport system, ATPase component	240
646447616	362	37.89	133	359	1	222	3.0e-50	192	COG0765	ABC-type amino acid transport system, permease component	222
646447617	392	59.13	4	392	10	397	0.0e+00	496	COG4597	ABC-type amino acid transport system, permease component	397
646447618	343	26.62	4	275	1	273	1.0e-28	120	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646447620	221	50.68	1	218	3	221	1.0e-54	206	COG0765	ABC-type amino acid transport system, permease component	222
646447621	256	38.72	1	254	2	267	4.0e-38	151	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646447622	380	17.58	115	379	30	257	2.0e-08	54.2	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	259
646447623	257	27.41	2	254	1	270	3.0e-30	125	COG3302	DMSO reductase anchor subunit	281
646447624	184	41.34	1	172	9	187	1.0e-41	162	COG0437	Fe-S-cluster-containing dehydrogenase component	203
646447625	765	30.59	7	734	1	753	2.0e-124	440	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
646447626	210	31.18	36	205	30	194	6.0e-22	97.7	COG3381	Cytoplasmic chaperone TorD involved in molybdoenzyme TorA maturation	204
646447628	98	91.84	1	98	1	98	2.0e-37	147	COG2901	DNA-binding protein Fis (factor for inversion stimulation)	98
646447629	321	47.53	1	321	2	322	2.0e-98	352	COG0042	tRNA-dihydrouridine synthase	323
646447630	295	54.52	1	293	2	300	3.0e-101	361	COG2264	Ribosomal protein L11 methylase PrmA	300
646447631	483	66.17	4	476	2	473	0.0e+00	566	COG4145	Na+/panthothenate symporter	473
646447632	80	68.35	1	79	1	79	2.0e-27	114	COG3924	Uncharacterized membrane protein YhdT	80
646447633	447	65.7	1	444	1	445	0.0e+00	640	COG0439	Biotin carboxylase	449
646447634	153	47.97	6	153	1	139	1.0e-25	109	COG0511	Biotin carboxyl carrier protein	140
646447635	150	60	6	150	2	146	2.0e-58	217	COG0757	3-dehydroquinate dehydratase	146
646447636	199	51.26	1	199	1	198	3.0e-42	165	COG2717	Periplasmic DMSO/TMAO reductase YedYZ, heme-binding membrane subunit	209
646447637	333	42.27	18	304	1	271	4.0e-66	244	COG2041	Periplasmic DMSO/TMAO reductase YedYZ, molybdopterin-dependent catalytic subunit	271
646447638	328	31.02	1	324	1	326	2.0e-54	206	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646447639	648	22.58	403	645	6	252	1.0e-29	125	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
646447640	347	70.06	5	346	1	342	0.0e+00	495	COG1077	Actin-like ATPase involved in cell morphogenesis	342
646447641	376	37.29	3	296	1	284	3.0e-75	275	COG1792	Cell shape-determining protein MreC	284
646447642	162	50	10	162	10	163	3.0e-25	107	COG2891	Cell shape-determining protein MreD	167
646447643	197	53.3	1	181	2	183	6.0e-57	213	COG0424	Predicted house-cleaning NTP pyrophosphatase, Maf/HAM1 superfamily	193
646447644	489	50.51	4	489	3	483	0.0e+00	541	COG1530	Ribonuclease G or E	487
646447645	1284	51.41	8	1278	2	1270	0.0e+00	1224	COG3164	Uncharacterized conserved protein YhdP, contains DUF3971 and AsmA2 domains	1271
646447646	481	42.52	18	480	2	454	3.0e-122	432	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
646447647	314	28.43	3	296	2	295	4.0e-39	155	COG0583	DNA-binding transcriptional regulator, LysR family	297
646447649	315	36.81	1	296	2	343	8.0e-60	224	COG1566	Multidrug resistance efflux pump	352
646447650	650	28.15	1	648	2	662	3.0e-72	266	COG1289	Uncharacterized membrane protein YccC	674
646447652	208	38.16	1	206	1	206	2.0e-27	115	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
646447653	182	69.95	1	182	1	183	4.0e-57	214	COG3028	Ribosomal 50S subunit-associated protein YjgA (function unknown), DUF615 family	187
646447654	446	39.25	15	446	2	449	2.0e-95	342	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
646447655	136	34.85	3	127	21	151	8.0e-18	83	COG0782	Transcription elongation factor, GreA/GreB family	151
646447656	90	46.07	2	90	1	88	6.0e-19	85.6	COG1925	Phosphotransferase system, HPr and related phosphotransfer proteins	88
646447657	284	61.46	1	282	1	286	6.0e-110	390	COG1660	RNase adaptor protein for sRNA GlmZ degradation, contains a P-loop ATPase domain	286
646447658	163	36.6	8	158	1	151	1.0e-27	115	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
646447659	95	58.76	1	95	1	97	6.0e-25	105	COG1544	Ribosome-associated translation inhibitor RaiA	110
646447660	477	55.32	1	477	1	444	0.0e+00	512	COG1508	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog	444
646447661	241	73.14	1	241	2	243	2.0e-114	404	COG1137	ABC-type lipopolysaccharide export system, ATPase component	243
646447662	192	50.3	13	177	9	172	1.0e-44	172	COG1934	Lipopolysaccharide export system protein LptA	173
646447663	189	47.31	2	186	1	185	2.0e-46	178	COG3117	Lipopolysaccharide export system protein LptC	188
646447664	188	63.53	19	188	1	170	9.0e-67	246	COG1778	 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases	170
646447665	328	57.92	12	212	1	202	5.0e-71	261	COG0794	D-arabinose 5-phosphate isomerase GutQ	202
646447666	320	49.53	1	319	8	320	7.0e-59	221	COG0530	Ca2+/Na+ antiporter	320
646447667	268	59.39	1	260	3	263	1.0e-105	376	COG1127	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, ATPase component MlaF	263
646447668	260	49.81	1	259	7	264	3.0e-72	265	COG0767	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, permease component MlaE	267
646447670	210	54.73	1	199	3	202	1.0e-64	239	COG2854	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, periplasmic MlaC component	202
646447671	97	47.47	1	97	1	99	2.0e-19	87.2	COG3113	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, MlaB component, contains STAS domain	99
646447672	84	70	1	80	1	80	8.0e-30	121	COG5007	Acid stress-induced BolA-like protein IbaG/YrbA, predicted regulator of iron metabolism	80
646447673	420	65.24	1	418	1	420	0.0e+00	652	COG0766	UDP-N-acetylglucosamine enolpyruvyl transferase	421
646447674	355	42.86	14	355	1	345	3.0e-66	245	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646447675	456	47.75	6	360	2	339	2.0e-76	279	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646447676	134	67.19	1	128	6	133	5.0e-47	179	COG3105	Uncharacterized membrane-anchored protein YhcB, DUF1043 family	138
646447677	376	50.67	1	375	6	367	0.0e+00	462	COG1485	Predicted ATPase	367
646447678	142	64.34	1	142	1	143	1.0e-56	212	COG0102	Ribosomal protein L13	148
646447679	130	66.15	1	130	1	130	3.0e-47	180	COG0103	Ribosomal protein S9	130
646447680	213	36.19	11	206	1	208	6.0e-31	127	COG0625	Glutathione S-transferase	211
646447681	168	63.86	3	168	2	155	8.0e-53	199	COG2969	Stringent starvation protein B	155
646447682	136	30.3	1	129	1	131	3.0e-19	87.8	COG3791	Uncharacterized conserved protein	133
646447683	472	45.93	24	470	2	450	0.0e+00	506	COG0493	NADPH-dependent glutamate synthase beta chain or related oxidoreductase	457
646447684	1486	60.29	692	1174	1	485	0.0e+00	665	COG0069	Glutamate synthase domain 2	485
646447685	314	55.77	6	312	2	312	1.0e-127	449	COG1242	Radical SAM superfamily enzyme	312
646447687	217	70.97	1	217	1	217	1.0e-90	325	COG3155	Enhancing lycopene biosynthesis protein 2	217
646447690	191	53.12	1	191	5	196	8.0e-47	180	COG2823	Osmotically-inducible protein OsmY, contains BON domain	196
646447691	196	66.48	1	179	1	176	9.0e-66	243	COG0279	Phosphoheptose isomerase	176
646447692	118	53.51	3	115	1	113	4.0e-31	126	COG0792	Predicted endonuclease distantly related to archaeal Holliday junction resolvase	114
646447693	687	42.24	1	687	1	604	7.0e-127	448	COG3107	Outer membrane lipoprotein LpoA, binds and activates PBP1a	604
646447694	295	58.99	8	285	1	275	1.0e-106	379	COG0313	16S rRNA C1402 (ribose-2'-O) methylase RsmI	275
646447696	262	52.26	1	262	4	267	1.0e-85	309	COG3384	Aromatic ring-opening dioxygenase, catalytic subunit, LigB family	268
646447697	386	61.18	1	386	1	387	0.0e+00	536	COG0754	Glutathionylspermidine synthase	387
646447698	243	41.29	1	197	2	190	6.0e-40	157	COG5463	Uncharacterized conserved protein YgiB, involved in bioifilm formation, UPF0441/DUF1190 family	198
646447699	470	30.73	7	436	27	455	8.0e-52	198	COG1538	Outer membrane protein TolC	457
646447701	140	72.86	1	140	6	145	1.0e-53	201	COG3151	Uncharacterized protein YqiB, DUF1249 family	147
646447702	275	35.61	15	275	1	270	7.0e-39	154	COG1409	3',5'-cyclic AMP phosphodiesterase CpdA	301
646447703	193	52.66	3	190	1	188	2.0e-74	271	COG3150	Predicted esterase YcpF, UPF0227 family	191
646447704	631	48.67	1	631	1	635	0.0e+00	878	COG0187	DNA gyrase/topoisomerase IV, subunit B	635
646447705	298	35.12	4	297	2	295	1.0e-36	147	COG0583	DNA-binding transcriptional regulator, LysR family	297
646447706	193	34.83	3	193	2	189	3.0e-42	164	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	189
646447707	758	43.68	1	746	1	747	0.0e+00	799	COG0188	DNA gyrase/topoisomerase IV, subunit A	804
646447708	245	29.17	5	238	1	236	6.0e-34	137	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
646447709	469	39.62	5	469	1	450	2.0e-79	290	COG2132	Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA)	451
646447710	281	47.29	2	271	1	276	2.0e-94	338	COG0656	Aldo/keto reductase, related to diketogulonate reductase	280
646447711	387	66.41	1	387	1	384	0.0e+00	606	COG1979	Alcohol dehydrogenase YqhD, Fe-dependent ADH family	384
646447712	246	32.04	1	186	2	207	2.0e-23	103	COG0778	Nitroreductase	207
646447713	304	42.02	180	298	8	126	8.0e-24	104	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646447714	219	33.67	22	219	10	208	5.0e-31	127	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
646447715	397	38.04	4	395	6	396	4.0e-118	418	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
646447716	311	44.39	82	292	1	214	6.0e-47	181	COG0811	Biopolymer transport protein ExbB/TolQ	216
646447717	139	46.67	3	137	1	135	2.0e-35	141	COG0848	Biopolymer transport protein ExbD	137
646447718	346	36.53	14	345	1	331	3.0e-67	249	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646447719	470	47.18	24	447	26	463	1.0e-130	460	COG1621	Sucrose-6-phosphate hydrolase SacC, GH32 family	486
646447720	456	33.6	95	452	1	375	6.0e-67	248	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
646447721	538	26.47	111	538	18	429	7.0e-32	132	COG4580	Maltoporin (phage lambda and maltose receptor)	429
646447722	307	35.83	4	307	1	307	3.0e-52	199	COG0524	Sugar or nucleoside kinase, ribokinase family	311
646447723	917	24.28	81	764	12	621	1.0e-73	271	COG1203	CRISPR/Cas system-associated endonuclease/helicase Cas3	733
646447730	307	20.92	11	306	1	323	1.0e-50	193	COG1518	CRISPR/Cas system-associated endonuclease Cas1	327
646447732	559	34.8	129	511	1	408	2.0e-46	180	COG0840	Methyl-accepting chemotaxis protein	408
646447733	191	30.37	1	191	1	199	2.0e-17	82.4	COG3637	Opacity protein and related surface antigens	199
646447734	150	55.94	6	148	1	143	8.0e-52	195	COG3787	Uncharacterized conserved protein YhbP, UPF0306 family	145
646447735	154	35.54	1	154	2	167	4.0e-31	127	COG0602	Organic radical activating enzyme	212
646447736	712	44.83	1	706	1	699	0.0e+00	894	COG1328	Anaerobic ribonucleoside-triphosphate reductase	700
646447737	302	32.04	3	300	8	298	4.0e-47	182	COG2040	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)	300
646447738	513	27.65	1	512	6	556	5.0e-70	259	COG0747	ABC-type transport system, periplasmic component	556
646447739	344	41.64	29	343	1	317	5.0e-72	265	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646447740	273	38.76	5	259	21	278	1.0e-53	203	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646447741	535	44.3	1	521	2	539	0.0e+00	537	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
646447742	244	57.61	1	243	1	242	5.0e-92	330	COG3484	Predicted proteasome-type protease	255
646447743	272	29.97	1	254	11	297	9.0e-31	127	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
646447744	309	35.35	1	309	1	310	3.0e-60	225	COG2307	Uncharacterized conserved protein, Alpha-E superfamily	313
646447745	481	55.16	7	478	5	479	0.0e+00	652	COG2308	Uncharacterized conserved protein, circularly permuted ATPgrasp superfamily	488
646447748	128	51.16	1	128	3	129	4.0e-33	133	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
646447749	154	58.82	1	152	1	152	5.0e-53	200	COG1781	Aspartate carbamoyltransferase, regulatory subunit	153
646447750	311	54.89	1	308	1	314	3.0e-114	404	COG0540	Aspartate carbamoyltransferase, catalytic chain	316
646447751	155	40.52	1	153	1	153	3.0e-46	177	COG2731	Beta-galactosidase, beta subunit	154
646447752	478	47.49	1	477	1	456	0.0e+00	572	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
646447753	338	52.55	1	333	1	310	0.0e+00	465	COG0078	Ornithine carbamoyltransferase	310
646447754	143	75.71	4	143	1	135	3.0e-38	150	COG3076	Regulator of RNase E activity RraB	135
646447756	195	28.57	18	127	2	120	8.0e-08	50.4	COG1396	Transcriptional regulator, contains XRE-family HTH domain	120
646447758	355	26.81	15	348	2	366	2.0e-44	173	COG2021	Homoserine acetyltransferase	368
646447759	539	36.1	167	515	35	408	5.0e-50	192	COG0840	Methyl-accepting chemotaxis protein	408
646447760	164	30.2	11	157	3	150	6.0e-26	110	COG1438	Arginine repressor	150
646447761	468	48.54	2	466	7	479	0.0e+00	477	COG1288	Uncharacterized membrane protein YfcC, ion transporter superfamily	481
646447762	334	53.78	2	332	1	309	0.0e+00	463	COG0078	Ornithine carbamoyltransferase	310
646447763	406	45.65	1	406	2	409	0.0e+00	471	COG2235	Arginine deiminase	409
646447764	951	55.19	1	950	1	877	0.0e+00	1241	COG0525	Valyl-tRNA synthetase	877
646447765	149	50	1	148	1	143	1.0e-38	151	COG2927	DNA polymerase III, chi subunit	144
646447766	502	51.3	1	497	1	485	0.0e+00	589	COG0260	Leucyl aminopeptidase	485
646447767	372	36.09	1	352	2	364	2.0e-60	226	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
646447768	356	35.64	2	356	1	362	2.0e-63	236	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
646447770	417	20.68	84	400	2	309	4.0e-09	56.5	COG0582	Integrase	309
646447773	507	40.08	5	507	2	488	1.0e-98	353	COG0286	Type I restriction-modification system, DNA methylase subunit	489
646447774	396	26.42	108	388	93	391	2.0e-21	97	COG0732	Restriction endonuclease S subunit	391
646447775	348	59.16	11	343	1	328	8.0e-128	450	COG3943	Uncharacterized conserved protein	329
646447776	1094	26.46	9	993	1	907	2.0e-113	404	COG0610	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ...	962
646447777	240	31.25	23	230	22	214	2.0e-30	125	COG1451	Predicted metal-dependent hydrolase	223
646447778	304	51.3	1	304	1	306	5.0e-102	364	COG1715	Restriction endonuclease Mrr	308
646447780	70	38.98	10	67	11	69	1.0e-11	61.1	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
646447783	288	44.41	1	288	1	295	7.0e-78	284	COG3596	Predicted GTPase	296
646447789	82	33.33	8	73	4	69	2.0e-06	44.2	COG3905	Predicted transcriptional regulator	83
646447794	282	41.22	20	280	25	276	1.0e-53	203	COG1741	Redox-sensitive bicupin YhaK, pirin superfamily	276
646447799	160	42.11	1	152	4	154	2.0e-30	125	COG1522	DNA-binding transcriptional regulator, Lrp family	154
646447804	205	43.5	3	202	2	200	3.0e-48	184	COG1279	Arginine exporter protein ArgO	202
646447807	482	37.36	14	456	3	441	2.0e-100	360	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
646447809	143	37.21	18	142	44	172	1.0e-21	95.6	COG2128	Alkylhydroperoxidase family enzyme, contains CxxC motif	177
646447811	386	31.15	1	374	2	373	5.0e-43	169	COG4637	Predicted ATPase	373
646447812	263	38.74	11	263	3	253	6.0e-56	210	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646447813	289	48.33	24	258	6	243	2.0e-73	269	COG3959	Transketolase, N-terminal subunit	243
646447814	307	36.42	1	294	5	304	5.0e-73	267	COG3958	Transketolase, C-terminal subunit	312
646447815	267	34.9	19	265	1	251	3.0e-43	168	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646447816	311	33.76	1	310	9	321	6.0e-45	174	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646447817	207	28.3	1	205	11	206	5.0e-18	84.7	COG5618	Predicted periplasmic lipoprotein	206
646447818	532	46.26	28	531	1	500	0.0e+00	553	COG1129	ABC-type sugar transport system, ATPase component	500
646447819	355	43.16	7	334	4	316	2.0e-59	223	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646447820	503	42.2	1	496	2	494	0.0e+00	508	COG0554	Glycerol kinase	499
646447821	265	40.38	4	262	2	250	1.0e-50	193	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646447822	514	26.07	6	514	1	553	2.0e-68	253	COG0747	ABC-type transport system, periplasmic component	556
646447823	305	47.77	1	303	1	314	1.0e-83	303	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646447824	308	49.46	26	301	10	281	2.0e-65	242	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646447825	345	55.84	22	335	1	312	2.0e-120	425	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
646447827	472	23.48	21	458	17	409	3.0e-28	120	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646447828	310	29.14	1	300	1	297	1.0e-30	127	COG0583	DNA-binding transcriptional regulator, LysR family	297
646447829	338	54.03	1	335	1	323	2.0e-118	418	COG2515	1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase, PLP-dependent ACC family	323
646447831	166	39.6	16	164	5	152	2.0e-30	125	COG1522	DNA-binding transcriptional regulator, Lrp family	154
646447832	176	34.18	22	99	22	100	1.0e-10	60	COG1605	Chorismate mutase	101
646447834	236	30.54	17	216	27	222	6.0e-26	111	COG1418	HD superfamily phosphodieaserase, includes HD domain of RNase Y	222
646447835	268	40.08	15	261	1	244	3.0e-52	198	COG1414	DNA-binding transcriptional regulator, IclR family	246
646447836	531	34.2	163	519	26	408	5.0e-42	165	COG0840	Methyl-accepting chemotaxis protein	408
646447837	104	54.29	1	104	1	105	5.0e-34	135	COG3254	L-rhamnose mutarotase	105
646447838	276	25.28	2	264	1	214	1.0e-34	140	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
646447839	418	80.38	1	418	1	418	0.0e+00	709	COG4806	L-rhamnose isomerase	419
646447840	490	27.57	1	481	1	490	3.0e-85	309	COG1070	Sugar (pentulose or hexulose) kinase	502
646447841	278	39.6	174	274	22	122	2.0e-20	93.4	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646447845	566	48.31	6	558	2	539	0.0e+00	572	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
646447846	303	45.13	23	298	6	282	2.0e-57	216	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646447847	321	38.91	14	313	6	314	7.0e-65	241	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646447848	541	27.09	9	541	7	554	1.0e-70	261	COG0747	ABC-type transport system, periplasmic component	556
646447851	407	24.64	1	403	1	409	2.0e-43	170	COG4102	Uncharacterized conserved protein, DUF1501 family	418
646447852	648	27.74	42	423	58	462	6.0e-53	202	COG5267	Uncharacterized conserved protein, DUF1800 family	496
646447853	179	57.06	1	170	2	171	1.0e-49	189	COG3477	Uncharacterized membrane protein YagU, involved in acid resistance, DUF1440 family	176
646447854	403	36.2	2	392	1	385	6.0e-77	281	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
646447855	392	38.58	1	390	3	386	3.0e-72	266	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
646447856	442	33.9	11	421	1	375	4.0e-76	278	COG0006	Xaa-Pro aminopeptidase	384
646447857	194	62.5	3	194	1	186	5.0e-65	240	COG3079	Uncharacterized conserved protein YgfB, UPF0149 family	186
646447858	109	43.81	3	107	1	105	8.0e-21	91.9	COG3027	Cell division protein ZapA, inhibits GTPase activity of FtsZ	105
646447860	204	39.47	17	204	5	190	1.0e-46	179	COG0212	5-formyltetrahydrofolate cyclo-ligase	191
646447861	419	75.27	225	410	2	186	3.0e-78	285	COG3172	Nicotinamide riboside kinase	187
646447862	461	62.26	1	461	1	456	0.0e+00	680	COG1066	Predicted ATP-dependent serine protease	456
646447863	325	50.24	108	317	2	212	9.0e-58	217	COG0560	Phosphoserine phosphatase	212
646447864	226	60.77	1	208	1	208	6.0e-63	233	COG3726	Uncharacterized membrane protein affecting hemolysin expression	214
646447865	258	56.03	2	258	1	257	6.0e-93	333	COG4106	Trans-aconitate methyltransferase	257
646447866	529	74.76	3	529	2	528	0.0e+00	935	COG4108	Peptide chain release factor RF-3	528
646447867	211	36.9	44	210	31	195	1.0e-25	110	COG2823	Osmotically-inducible protein OsmY, contains BON domain	196
646447870	289	40.32	34	285	3	254	5.0e-77	281	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
646447871	239	35.91	17	236	8	225	1.0e-42	166	COG2977	4'-phosphopantetheinyl transferase EntD (siderophore biosynthesis)	228
646447872	264	51.49	1	233	1	233	8.0e-72	263	COG3967	Short-chain dehydrogenase involved in D-alanine esterification of teichoic acids	245
646447873	574	36.61	149	530	2	408	1.0e-51	198	COG0840	Methyl-accepting chemotaxis protein	408
646447877	271	38.43	7	255	1	254	1.0e-58	220	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
646447878	330	22.75	8	328	1	316	2.0e-33	136	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
646447879	332	46.99	5	332	2	329	8.0e-51	194	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
646447880	187	48.94	1	184	2	188	2.0e-62	231	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	194
646447881	520	71.15	1	520	1	519	0.0e+00	838	COG3634	Alkyl hydroperoxide reductase subunit AhpF	520
646447882	276	38.67	42	266	21	239	7.0e-59	220	COG5255	Uncharacterized protein	239
646447883	225	33.33	13	181	20	189	1.0e-24	106	COG0110	Acetyltransferase (isoleucine patch superfamily)	190
646447884	165	29.59	1	165	5	173	8.0e-12	63.4	COG3195	2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) decarboxylase	176
646447885	795	42.16	89	783	2	709	0.0e+00	668	COG2217	Cation transport ATPase	713
646447886	143	35.09	1	113	1	114	4.0e-20	90.6	COG0789	DNA-binding transcriptional regulator, MerR family	124
646447887	340	34.04	16	340	1	329	2.0e-70	259	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646447888	399	39.12	42	393	11	371	6.0e-74	271	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646447889	468	44.83	238	468	1	226	4.0e-67	249	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
646447891	185	34.43	14	181	23	204	2.0e-25	109	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
646447892	715	23.19	7	460	3	458	7.0e-42	166	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
646447895	329	20.23	3	254	1	252	2.0e-13	70.2	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646447896	403	23.52	1	403	1	381	1.0e-34	140	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646447897	367	23.38	4	365	1	377	8.0e-30	124	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646447905	191	22.89	3	167	14	179	3.0e-06	45.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646447906	582	50.6	6	582	1	569	0.0e+00	581	COG4232	Thiol:disulfide interchange protein	569
646447907	126	43.27	23	126	1	104	4.0e-31	126	COG1324	Uncharacterized protein involved in tolerance to divalent cations	104
646447908	433	60.55	1	433	1	436	0.0e+00	517	COG2704	Anaerobic C4-dicarboxylate transporter	436
646447909	479	73.83	4	473	3	471	0.0e+00	796	COG1027	Aspartate ammonia-lyase	471
646447910	176	46.62	1	147	1	148	3.0e-38	151	COG3030	Protein affecting phage T7 exclusion by the F plasmid, UPF0716 family	158
646447911	97	63.92	1	97	1	96	2.0e-28	117	COG0234	Co-chaperonin GroES (HSP10)	96
646447912	548	49.27	1	530	1	520	0.0e+00	497	COG0459	Chaperonin GroEL (HSP60 family)	524
646447913	171	33.72	9	166	2	173	4.0e-25	107	COG3161	4-hydroxybenzoate synthetase (chorismate-pyruvate lyase)	174
646447914	294	43.93	16	294	9	288	3.0e-55	208	COG0382	4-hydroxybenzoate polyprenyltransferase	289
646447915	829	65.48	1	809	1	809	0.0e+00	1073	COG2937	Glycerol-3-phosphate O-acyltransferase	810
646447916	121	55.83	1	120	2	121	4.0e-32	130	COG0818	Diacylglycerol kinase	123
646447917	203	49.25	1	199	1	199	2.0e-58	218	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	201
646447918	169	31.72	8	152	3	145	2.0e-31	128	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
646447919	235	32.93	1	233	1	242	1.0e-39	157	COG1741	Redox-sensitive bicupin YhaK, pirin superfamily	276
646447920	298	25.34	7	298	1	294	2.0e-25	109	COG0583	DNA-binding transcriptional regulator, LysR family	297
646447921	328	68.92	1	325	1	322	0.0e+00	520	COG0435	Glutathionyl-hydroquinone reductase	324
646447922	131	38.46	5	131	12	141	2.0e-14	71.2	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
646447924	132	60	1	130	1	130	5.0e-27	113	COG5393	Uncharacterized membrane protein YqjE	131
646447925	101	56.38	8	101	11	104	1.0e-24	104	COG4575	Membrane-anchored ribosome-binding protein, inhibits growth in stationary phase, ElaB/YqjD/DUF883 family	104
646447927	224	35.42	26	216	14	205	5.0e-33	134	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
646447928	259	33.19	1	233	3	238	9.0e-48	183	COG2186	DNA-binding transcriptional regulator, FadR family	241
646447929	433	24.77	5	425	24	447	3.0e-29	123	COG2271	Sugar phosphate permease	448
646447931	469	59.57	3	467	1	463	0.0e+00	687	COG1904	Glucuronate isomerase	463
646447932	483	32.92	4	482	3	473	1.0e-114	407	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
646447933	496	53.79	103	496	1	381	0.0e+00	535	COG2721	Altronate dehydratase	381
646447935	317	30.89	77	317	18	250	7.0e-39	154	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
646447936	386	34.08	72	385	2	300	1.0e-80	293	COG2813	16S rRNA G1207 methylase RsmC	300
646447938	196	44.39	2	194	1	205	2.0e-48	185	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646447939	503	67.62	8	496	4	493	0.0e+00	606	COG3851	Signal transduction histidine kinase, glucose-6-phosphate specific	497
646447940	453	50.57	14	448	3	441	0.0e+00	513	COG2271	Sugar phosphate permease	448
646447941	463	44.32	2	456	1	446	4.0e-128	451	COG2271	Sugar phosphate permease	448
646447942	157	37.33	1	150	2	149	2.0e-18	85.4	COG3678	Periplasmic protein refolding chaperone Spy/CpxP family	160
646447943	349	41.45	5	345	3	336	3.0e-90	325	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
646447944	561	26.97	30	445	2	387	2.0e-80	293	COG0119	Isopropylmalate/homocitrate/citramalate synthases	409
646447945	267	29.17	148	266	2	121	6.0e-17	81.4	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646447946	925	36.61	5	364	4	362	1.0e-82	301	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646447947	323	35.65	1	315	24	337	3.0e-75	275	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
646447948	193	19.37	1	191	2	191	1.0e-08	53.1	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646447949	349	39.06	1	316	1	309	2.0e-69	256	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646447950	287	38.52	7	259	9	265	3.0e-61	228	COG0300	Short-chain dehydrogenase	265
646447953	611	50.42	254	610	1	342	1.0e-100	360	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
646447954	584	42.51	4	573	1	556	0.0e+00	513	COG0358	DNA primase (bacterial type)	568
646447955	71	61.19	1	67	1	67	2.0e-06	44.5	COG0828	Ribosomal protein S21	67
646447956	337	57.31	1	337	1	340	0.0e+00	463	COG0533	tRNA A37 threonylcarbamoyltransferase TsaD	342
646447957	156	51.33	6	152	3	150	1.0e-42	165	COG1438	Arginine repressor	150
646447958	313	37.77	1	311	1	312	2.0e-68	253	COG0039	Malate/lactate dehydrogenase	313
646447959	93	72.84	1	81	1	81	6.0e-26	108	COG3423	Predicted transcriptional regulator, lambda repressor-like DNA-binding domain	82
646447962	323	38.23	4	323	1	322	6.0e-81	294	COG0142	Geranylgeranyl pyrophosphate synthase	322
646447963	103	62.14	1	103	1	103	2.0e-34	137	COG0261	Ribosomal protein L21	103
646447964	85	81.18	1	85	1	84	6.0e-32	128	COG0211	Ribosomal protein L27	87
646447966	391	63.81	1	360	1	361	0.0e+00	545	COG0536	GTPase involved in cell partioning and DNA repair	369
646447967	477	45.82	1	476	1	470	0.0e+00	491	COG2027	D-alanyl-D-alanine carboxypeptidase	470
646447968	158	55.26	6	157	1	150	2.0e-44	172	COG0782	Transcription elongation factor, GreA/GreB family	151
646447969	97	59.79	2	97	1	97	6.0e-27	112	COG1534	RNA-binding protein YhbY	97
646447970	209	58.91	7	208	1	202	2.0e-76	278	COG0293	23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ	205
646447971	650	62.06	9	604	1	596	0.0e+00	804	COG0465	ATP-dependent Zn proteases	596
646447972	277	48.87	15	277	8	269	5.0e-81	294	COG0294	Dihydropteroate synthase	274
646447973	445	46.84	1	444	4	460	9.0e-123	434	COG1109	Phosphomannomutase	464
646447974	111	50	1	80	1	79	3.0e-16	77.2	COG1314	Preprotein translocase subunit SecG	86
646447977	152	55.56	1	152	1	153	3.0e-51	194	COG0779	Ribosome maturation factor RimP	153
646447978	496	51.53	157	351	1	190	2.0e-51	196	COG0195	Transcription antitermination factor NusA, contains S1 and KH domains	190
646447979	905	67.32	402	905	1	508	0.0e+00	699	COG0532	Translation initiation factor IF-2, a GTPase	509
646447980	133	50	1	120	1	118	1.0e-30	125	COG0858	Ribosome-binding factor A	118
646447981	318	38.91	1	311	4	271	9.0e-70	257	COG0130	tRNA U55 pseudouridine synthase TruB, may also work on U342 of tmRNA	271
646447982	89	61.8	1	89	1	89	4.0e-28	116	COG0184	Ribosomal protein S15P/S13E	89
646447983	706	66.18	1	692	1	690	0.0e+00	1033	COG1185	Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)	692
646447984	294	80.13	1	294	1	297	9.0e-128	449	COG4785	Lipoprotein NlpI, contains TPR repeats	297
646447985	624	41.57	3	488	26	511	3.0e-124	439	COG0513	Superfamily II DNA and RNA helicase	513
646447986	339	26.13	15	328	2	331	1.0e-42	167	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
646447987	292	24.12	2	292	1	304	6.0e-56	211	COG0826	Collagenase-like protease, PrtC family	347
646447988	332	37.39	1	332	7	312	2.0e-82	299	COG0826	Collagenase-like protease, PrtC family	347
646447989	174	57.23	6	164	1	158	4.0e-46	177	COG3154	Predicted lipid carrier protein YhbT, SCP2 domain	168
646447990	167	51.48	1	167	4	171	9.0e-43	166	COG3153	Predicted N-acetyltransferase YhbS	171
646447991	100	51.85	8	88	5	85	4.0e-24	102	COG2827	Predicted endonuclease, GIY-YIG superfamily	95
646447992	259	37.45	4	254	1	227	8.0e-55	206	COG0274	Deoxyribose-phosphate aldolase	228
646447993	443	52.28	1	438	1	434	0.0e+00	545	COG0213	Thymidine phosphorylase	435
646447994	407	63.86	1	404	1	390	0.0e+00	606	COG1015	Phosphopentomutase	397
646447995	241	73.31	1	236	1	236	1.0e-112	399	COG0813	Purine-nucleoside phosphorylase	236
646447996	147	30.3	1	146	11	173	2.0e-20	91.6	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
646447997	139	59.26	2	135	1	133	6.0e-37	146	COG3050	DNA polymerase III, psi subunit	133
646447998	342	47.64	42	335	3	298	8.0e-91	327	COG2813	16S rRNA G1207 methylase RsmC	300
646447999	300	32.66	5	298	4	295	2.0e-34	139	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448004	301	33.78	1	297	1	290	2.0e-38	153	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448005	262	41.45	28	261	1	234	2.0e-69	255	COG3527	Alpha-acetolactate decarboxylase	234
646448006	559	36.76	11	550	2	539	2.0e-130	459	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
646448007	383	45.31	2	383	1	377	2.0e-114	406	COG1454	Alcohol dehydrogenase, class IV	377
646448008	366	47.11	1	362	4	375	3.0e-106	378	COG0404	Glycine cleavage system T protein (aminomethyltransferase)	379
646448009	135	58.46	1	129	2	131	5.0e-41	159	COG0509	Glycine cleavage system H protein (lipoate-binding)	131
646448010	957	66.31	471	928	28	493	0.0e+00	744	COG1003	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain	496
646448011	202	28.28	13	153	2	145	2.0e-12	65.8	COG1896	5'-deoxynucleotidase YfbR and related HD superfamily hydrolases	193
646448012	222	57.89	16	221	16	223	8.0e-51	193	COG1272	Predicted membrane channel-forming protein YqfA, hemolysin III family	226
646448013	326	38.89	5	326	1	305	1.0e-70	260	COG0354	Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification	305
646448014	90	54.12	3	87	10	94	1.0e-25	108	COG2938	Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module	94
646448016	172	31.76	1	168	2	151	2.0e-28	118	COG0716	Flavodoxin	151
646448017	441	20.05	72	432	71	433	4.0e-10	59.4	COG2271	Sugar phosphate permease	448
646448018	299	63.79	1	299	1	300	2.0e-118	418	COG4974	Site-specific recombinase XerD	300
646448019	238	26.34	1	232	4	244	4.0e-35	141	COG1651	Protein-disulfide isomerase	244
646448020	576	43.1	36	553	2	491	4.0e-118	419	COG0608	Single-stranded DNA-specific exonuclease, DHH superfamily, may be involved in archaeal DNA replication intiation	491
646448021	365	65.69	128	365	1	239	8.0e-102	363	COG1186	Protein chain release factor B	239
646448022	505	64	9	505	4	502	0.0e+00	759	COG1190	Lysyl-tRNA synthetase (class II)	502
646448023	223	24.54	1	214	2	207	4.0e-10	58.4	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
646448026	240	47.19	6	235	2	229	2.0e-62	232	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646448027	199	39.8	9	199	22	216	5.0e-39	153	COG4117	Thiosulfate reductase cytochrome b subunit	221
646448028	256	32.1	25	256	2	244	1.0e-45	176	COG2041	Periplasmic DMSO/TMAO reductase YedYZ, molybdopterin-dependent catalytic subunit	271
646448030	125	43.52	10	117	10	117	1.0e-27	115	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646448031	355	67.33	1	351	1	337	0.0e+00	577	COG1088	dTDP-D-glucose 4,6-dehydratase	340
646448032	287	59.93	1	287	1	284	1.0e-118	419	COG1209	dTDP-glucose pyrophosphorylase	286
646448033	183	59.78	1	179	1	173	8.0e-58	216	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	173
646448034	470	41.94	4	337	2	333	1.0e-111	396	COG0836	Mannose-1-phosphate guanylyltransferase	333
646448035	453	34.63	1	453	5	459	1.0e-99	357	COG1109	Phosphomannomutase	464
646448036	283	27.52	29	283	7	263	4.0e-40	158	COG1682	ABC-type polysaccharide/polyol phosphate export permease	263
646448037	250	42.5	2	241	1	234	8.0e-75	273	COG1134	ABC-type polysaccharide/polyol phosphate transport system, ATPase component	249
646448038	464	22.43	71	458	25	430	1.0e-29	125	COG1541	Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family	438
646448040	375	44.74	1	366	4	369	2.0e-102	366	COG0381	UDP-N-acetylglucosamine 2-epimerase	383
646448041	402	19.63	88	395	57	372	2.0e-12	67.4	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448042	480	20.78	122	445	21	315	2.0e-15	77.7	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
646448044	634	20.78	256	593	31	381	4.0e-15	77	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448045	1006	17.47	677	1005	73	379	6.0e-13	70.4	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448046	323	23.47	40	305	85	356	2.0e-06	46.9	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448047	208	30.11	1	178	3	188	1.0e-27	116	COG0406	Broad specificity phosphatase PhoE	208
646448049	460	26.8	16	410	10	380	3.0e-29	123	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448050	327	22.36	18	324	68	381	1.0e-19	90.5	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448051	375	27.18	2	371	1	381	3.0e-35	142	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448052	629	42.11	19	623	1	584	0.0e+00	632	COG1086	NDP-sugar epimerase, includes UDP-GlcNAc-inverting 4,6-dehydratase FlaA1 and capsular polysaccharide biosynthesis protein EpsC	588
646448053	300	29.11	5	288	33	311	4.0e-33	135	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646448054	182	44.57	3	181	42	225	1.0e-46	179	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
646448055	440	28.84	11	430	13	433	4.0e-39	155	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
646448056	361	51.14	1	349	1	338	3.0e-115	408	COG3839	ABC-type sugar transport system, ATPase component	338
646448057	273	26.1	1	235	1	237	2.0e-21	96.2	COG1409	3',5'-cyclic AMP phosphodiesterase CpdA	301
646448058	295	36.82	24	295	7	281	2.0e-49	189	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
646448059	290	37.24	1	290	6	295	3.0e-53	202	COG1175	ABC-type sugar transport system, permease component	295
646448060	142	43.08	76	140	4	68	1.0e-09	55.7	COG3585	Molybdopterin-binding protein	69
646448061	306	50	6	306	6	308	6.0e-93	334	COG1560	Lauroyl/myristoyl acyltransferase	308
646448062	455	44.9	14	453	2	436	3.0e-105	375	COG2252	Xanthine/uracil/vitamin C permease, AzgA family	436
646448063	548	38.18	1	440	6	422	2.0e-71	263	COG0025	NhaP-type Na+/H+ or K+/H+ antiporter	429
646448064	552	58.91	30	544	1	529	0.0e+00	561	COG4147	Na+(or H+)/acetate symporter ActP	529
646448065	103	64.08	1	103	1	102	6.0e-32	128	COG3162	Uncharacterized membrane protein, DUF485 family	102
646448066	653	44.78	68	631	1	528	0.0e+00	673	COG0365	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase	528
646448068	336	20.94	1	332	8	339	5.0e-08	52.6	COG0628	Predicted PurR-regulated permease PerM	355
646448069	508	27.62	1	471	5	466	4.0e-83	302	COG2211	Na+/melibiose symporter or related transporter	467
646448070	73	65.62	1	64	1	64	9.0e-19	84.9	COG3655	DNA-binding transcriptional regulator, XRE family	73
646448071	498	49.79	19	493	1	471	0.0e+00	547	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
646448073	373	30.66	16	373	11	342	2.0e-49	190	COG1566	Multidrug resistance efflux pump	352
646448074	151	35.09	20	132	4	116	9.0e-10	56.5	COG1846	DNA-binding transcriptional regulator, MarR family	126
646448075	487	36.73	19	485	2	457	1.0e-100	360	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
646448076	244	27.84	37	208	11	186	8.0e-17	80.8	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646448077	362	36.25	3	237	2	232	7.0e-36	144	COG1376	Lipoprotein-anchoring transpeptidase ErfK/SrfK	232
646448078	1177	40.41	1	383	3	361	3.0e-98	354	COG0674	Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit	365
646448080	181	32.58	2	173	1	177	3.0e-26	111	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646448083	160	22.83	46	159	47	173	6.0e-07	47.3	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
646448085	94	23.33	1	88	3	88	1.0e-11	61.1	COG2350	Uncharacterized conserved protein YciI, contains a putative active-site phosphohistidine	92
646448086	366	41.93	2	351	1	317	6.0e-93	334	COG1181	D-alanine-D-alanine ligase and related ATP-grasp enzymes	317
646448087	285	35.11	8	285	3	275	2.0e-50	192	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
646448088	503	39.79	4	486	1	471	7.0e-121	427	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646448089	643	54.9	1	643	2	617	0.0e+00	874	COG3962	TPP-dependent trihydroxycyclohexane-1,2-dione (THcHDO) dehydratase, myo-inositol metabolism	617
646448090	328	31.96	1	328	3	340	6.0e-52	198	COG0673	Predicted dehydrogenase	342
646448091	312	34.19	7	311	16	322	9.0e-47	180	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646448092	521	48.43	6	512	3	498	0.0e+00	615	COG1129	ABC-type sugar transport system, ATPase component	500
646448093	346	48.9	27	345	8	315	4.0e-66	245	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646448094	377	30.75	1	373	1	340	7.0e-52	198	COG0673	Predicted dehydrogenase	342
646448095	653	55.03	339	653	6	303	3.0e-120	426	COG3892	Myo-inositol catabolism protein IolC	310
646448096	296	31.99	5	291	1	273	1.0e-41	163	COG1082	Sugar phosphate isomerase/epimerase	274
646448097	275	58.52	1	269	1	269	8.0e-111	393	COG3718	5-deoxy-D-glucuronate isomerase	270
646448098	367	34.41	1	366	3	341	2.0e-77	283	COG2951	Membrane-bound lytic murein transglycosylase B	343
646448100	260	25.82	1	259	1	271	2.0e-32	132	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646448104	683	29.2	3	353	10	363	7.0e-50	192	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
646448106	363	27.19	130	327	70	291	7.0e-18	85.3	COG4974	Site-specific recombinase XerD	300
646448121	591	22.62	1	300	1	275	7.0e-26	112	COG5484	Uncharacterized protein YjcR	279
646448138	394	19.94	16	340	1	305	9.0e-06	45	COG3299	Uncharacterized phage protein gp47/JayE	353
646448147	160	60.78	8	160	2	153	2.0e-55	208	COG0691	tmRNA-binding protein	153
646448148	144	59.44	1	142	1	143	2.0e-53	201	COG2867	Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module	146
646448149	97	66.67	1	96	1	96	2.0e-31	126	COG2914	Putative antitoxin component PasI (RatB) of the RatAB toxin-antitoxin module, ubiquitin-RnfH superfamily	99
646448150	114	43.7	1	114	4	121	8.0e-29	118	COG2913	Outer membrane protein assembly factor BamE, lipoprotein component of the BamABCDE complex	147
646448151	553	50.63	1	553	1	554	0.0e+00	635	COG0497	DNA repair ATPase RecN	557
646448152	292	46.85	6	289	1	281	2.0e-79	289	COG0061	NAD kinase	281
646448153	195	44.67	1	194	1	193	2.0e-39	155	COG0576	Molecular chaperone GrpE (heat shock protein)	193
646448154	411	45.74	8	411	6	414	2.0e-87	316	COG1914	Mn2+ and Fe2+ transporters of the NRAMP family	416
646448155	194	26.19	36	190	1	160	4.0e-06	44.6	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
646448156	316	38.1	4	314	1	239	4.0e-66	245	COG0176	Transaldolase	239
646448157	759	57.01	1	433	13	432	0.0e+00	599	COG0281	Malic enzyme	432
646448158	149	57.64	4	147	4	145	7.0e-50	189	COG1671	Uncharacterized conserved protein YaiI, UPF0178 family	150
646448159	312	67.66	1	302	2	303	0.0e+00	483	COG0408	Coproporphyrinogen III oxidase	303
646448160	141	33.33	1	123	12	149	7.0e-12	63.1	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
646448161	288	17.86	6	282	6	243	3.0e-13	69.4	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
646448163	929	24.89	17	452	1	422	2.0e-43	171	COG0612	Predicted Zn-dependent peptidase	438
646448164	553	40.78	2	549	23	586	0.0e+00	516	COG4178	ABC-type uncharacterized transport system, permease and ATPase components	604
646448167	415	18.68	39	400	47	389	6.0e-06	46	COG2814	Predicted arabinose efflux permease, MFS family	394
646448168	300	30.36	1	298	1	295	2.0e-37	149	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448169	422	18.43	3	338	19	380	6.0e-07	49	COG2271	Sugar phosphate permease	448
646448170	288	42.01	2	286	1	279	2.0e-77	282	COG0169	Shikimate 5-dehydrogenase	283
646448171	252	45.8	15	252	1	231	3.0e-62	231	COG0710	3-dehydroquinate dehydratase	231
646448172	530	58.51	11	529	1	522	0.0e+00	723	COG4670	Acyl CoA:acetate/3-ketoacid CoA transferase	527
646448173	383	37.31	1	383	1	393	1.0e-80	293	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
646448174	303	35.58	181	284	21	124	5.0e-21	95.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646448175	254	37.74	1	251	1	255	1.0e-53	203	COG2086	Electron transfer flavoprotein, alpha and beta subunits	260
646448176	317	35	5	317	1	312	2.0e-69	256	COG2025	Electron transfer flavoprotein, alpha subunit	313
646448177	429	35.42	3	429	1	396	5.0e-72	265	COG0644	Dehydrogenase (flavoprotein)	396
646448178	97	46.46	1	97	1	99	4.0e-33	132	COG2440	Ferredoxin-like protein FixX	99
646448179	584	39.66	40	567	3	533	1.0e-119	424	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646448180	94	73.75	1	80	1	80	1.0e-24	104	COG3423	Predicted transcriptional regulator, lambda repressor-like DNA-binding domain	82
646448183	431	23.95	1	422	3	425	2.0e-33	136	COG1457	Purine-cytosine permease or related protein	442
646448184	299	41.61	1	299	22	343	4.0e-84	304	COG2837	Periplasmic deferrochelatase/peroxidase EfeB	352
646448185	293	48.49	1	289	2	300	2.0e-102	365	COG0031	Cysteine synthase	300
646448186	654	50	5	226	1	224	2.0e-78	287	COG1136	ABC-type lipoprotein export system, ATPase component	226
646448187	405	27.72	1	385	4	353	3.0e-26	112	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646448188	226	45.18	1	226	1	226	2.0e-60	225	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646448189	473	27.11	133	473	1	331	1.0e-42	168	COG0642	Signal transduction histidine kinase	336
646448190	320	31.37	63	317	7	257	8.0e-39	154	COG1024	Enoyl-CoA hydratase/carnithine racemase	257
646448191	184	41.75	1	102	1	103	1.0e-20	92.8	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646448192	169	55.77	16	169	1	156	5.0e-48	183	COG2190	Phosphotransferase system IIA component	156
646448193	575	63.87	1	573	2	574	0.0e+00	814	COG1080	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)	574
646448194	85	50	1	84	1	84	2.0e-24	103	COG1925	Phosphotransferase system, HPr and related phosphotransfer proteins	88
646448195	322	61.81	4	308	1	300	1.0e-110	393	COG0031	Cysteine synthase	300
646448196	338	27.61	7	329	4	303	2.0e-34	140	COG3547	Transposase	303
646448197	260	62.71	12	247	7	242	2.0e-78	285	COG2981	Uncharacterized protein involved in cysteine biosynthesis	250
646448198	314	50	2	309	1	323	6.0e-78	284	COG3115	Cell division protein ZipA, interacts with FtsZ	324
646448199	455	25.47	42	445	7	433	4.0e-24	106	COG0531	Amino acid transporter	466
646448200	95	52.75	1	91	10	100	2.0e-18	83.9	COG2960	Uncharacterized conserved protein YqiC, BMFP domain	103
646448201	217	60.29	11	214	1	203	1.0e-80	292	COG0108	3,4-dihydroxy-2-butanone 4-phosphate synthase	203
646448202	287	52.63	1	95	5	99	5.0e-32	131	COG3615	Uncharacterized protein/domain, possibly involved in tellurite resistance	99
646448204	494	43.48	5	394	7	388	1.0e-128	453	COG0426	Flavorubredoxin	388
646448205	509	51.35	3	509	27	546	0.0e+00	560	COG3604	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains	550
646448206	547	44.81	38	344	1	297	3.0e-101	363	COG1951	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain	297
646448207	288	26.55	6	286	4	290	4.0e-29	122	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448208	154	47.18	12	153	5	146	6.0e-42	163	COG4125	Uncharacterized membrane protein	149
646448209	228	38.32	13	217	68	280	7.0e-45	173	COG0122	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase	285
646448210	217	47.03	5	205	4	192	4.0e-47	180	COG3145	Alkylated DNA repair dioxygenase AlkB	194
646448211	523	23.35	47	518	4	412	7.0e-27	115	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	562
646448213	459	22.34	4	369	12	381	8.0e-11	62.1	COG2814	Predicted arabinose efflux permease, MFS family	394
646448214	318	41.43	1	318	3	305	1.0e-48	187	COG3301	Formate-dependent nitrite reductase, membrane component NrfD	305
646448215	232	40.1	34	228	2	197	8.0e-51	193	COG0437	Fe-S-cluster-containing dehydrogenase component	203
646448217	330	29.04	58	323	58	312	4.0e-27	115	COG0657	Acetyl esterase/lipase	312
646448218	300	24.66	2	294	1	290	3.0e-29	122	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448219	328	33.43	6	328	1	326	2.0e-60	226	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646448220	255	24	1	231	2	276	2.0e-19	89.7	COG1234	Ribonuclease BN, tRNA processing enzyme	292
646448221	356	50.59	1	335	1	336	5.0e-119	421	COG3839	ABC-type sugar transport system, ATPase component	338
646448222	275	42.34	4	273	7	278	6.0e-49	188	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
646448223	290	43.94	1	288	4	292	2.0e-65	242	COG1175	ABC-type sugar transport system, permease component	295
646448224	426	27.66	27	426	14	431	9.0e-36	144	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
646448225	397	23.92	5	396	12	392	1.0e-19	91.4	COG2814	Predicted arabinose efflux permease, MFS family	394
646448228	361	47.19	6	361	4	347	3.0e-124	438	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
646448229	319	28.24	3	298	2	296	4.0e-33	135	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448230	280	60.5	12	130	14	132	5.0e-43	168	COG2904	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF, N-terminal domain	137
646448231	289	27.59	80	280	24	224	7.0e-27	114	COG1738	Uncharacterized PurR-regulated membrane protein YhhQ, DUF165 family	233
646448233	177	61.68	1	167	4	169	2.0e-47	182	COG2862	Uncharacterized membrane protein YqhA	169
646448234	753	30.95	7	750	46	761	3.0e-130	459	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
646448235	297	27.76	5	296	1	296	1.0e-28	120	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448236	150	32.2	29	141	20	131	9.0e-15	73.1	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
646448239	369	22.3	2	255	1	272	1.0e-18	88.1	COG3320	Thioester reductase domain of alpha aminoadipate reductase Lys2 and NRPSs	382
646448240	261	20.69	34	261	35	258	1.0e-20	93.8	COG3713	Outer membrane scaffolding protein for murein synthesis, MipA/OmpV family	258
646448241	231	43.59	4	231	1	228	5.0e-50	190	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646448242	389	32.29	73	389	20	330	3.0e-38	153	COG0642	Signal transduction histidine kinase	336
646448243	380	31.2	32	380	15	371	1.0e-27	117	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646448244	1021	30.08	10	1011	1	1007	0.0e+00	727	COG0841	Multidrug efflux pump subunit AcrB	1009
646448246	131	40.57	15	120	9	114	2.0e-24	104	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646448247	175	23.03	9	172	2	174	8.0e-14	70.3	COG0563	Adenylate kinase or related kinase	178
646448248	368	25	1	338	2	319	3.0e-35	143	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
646448251	380	27.4	14	358	11	348	2.0e-46	180	COG3177	Fic family protein	348
646448255	73	69.01	3	73	5	75	4.0e-23	99.7	COG3423	Predicted transcriptional regulator, lambda repressor-like DNA-binding domain	82
646448257	419	22.87	84	400	2	309	7.0e-12	65.4	COG0582	Integrase	309
646448259	717	46.02	97	710	1	551	0.0e+00	665	COG1982	Arginine/lysine/ornithine decarboxylase	557
646448261	485	48.48	14	475	1	458	0.0e+00	514	COG1113	L-asparagine transporter and related permeases	462
646448262	360	21.68	46	353	1	296	1.0e-36	147	COG0741	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)	296
646448263	90	84.09	1	88	1	88	2.0e-40	157	COG2924	Fe-S cluster biosynthesis and repair protein YggX	90
646448264	377	52.42	14	363	2	342	1.0e-121	430	COG1194	Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs	342
646448265	239	52.68	17	237	1	224	1.0e-77	282	COG0220	tRNA G46 methylase TrmB	227
646448266	114	65.77	1	111	9	119	1.0e-39	154	COG3171	Uncharacterized conserved protein YggL, DUF469 family	119
646448269	1048	26.31	491	1048	54	577	4.0e-41	164	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	577
646448270	346	42.41	1	346	1	316	2.0e-85	309	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646448272	238	47.95	1	238	7	250	2.0e-55	209	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
646448273	228	75	1	228	1	228	1.0e-102	365	COG3066	DNA mismatch repair protein MutH	229
646448274	175	22.89	2	161	4	160	3.0e-12	65	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
646448275	749	57.41	2	749	1	756	0.0e+00	955	COG3605	Signal transduction protein containing GAF and PtsI domains	756
646448276	287	48.8	1	283	1	277	6.0e-75	274	COG0682	Prolipoprotein diacylglyceryltransferase	287
646448277	264	68.8	1	264	3	268	9.0e-121	426	COG0207	Thymidylate synthase	268
646448278	163	17.57	6	153	5	142	7.0e-08	50.4	COG2165	Type II secretory pathway, pseudopilin PulG	149
646448279	197	32.12	7	195	3	194	4.0e-20	91.6	COG4795	Type II secretory pathway, component PulJ	194
646448282	965	50.05	21	955	2	936	0.0e+00	996	COG1025	Secreted/periplasmic Zn-dependent peptidases, insulinase-like	937
646448283	441	42.28	23	290	1	264	4.0e-78	285	COG0548	Acetylglutamate kinase	265
646448284	412	35.68	170	410	25	231	5.0e-51	195	COG0860	N-acetylmuramoyl-L-alanine amidase	231
646448287	386	49.33	1	361	1	369	2.0e-115	409	COG2821	Membrane-bound lytic murein transglycosylase	373
646448288	159	27.07	6	134	1	119	7.0e-08	50.3	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	153
646448289	337	34.9	21	317	20	312	4.0e-61	228	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
646448291	275	62.17	1	267	1	262	7.0e-106	376	COG1179	tRNA A37 threonylcarbamoyladenosine dehydratase	263
646448292	147	46.48	5	146	1	142	2.0e-39	155	COG2166	Sulfur transfer protein SufE, Fe-S center assembly	144
646448293	401	46.91	3	398	2	405	1.0e-118	420	COG0520	Selenocysteine lyase/Cysteine desulfurase	405
646448295	308	28.76	6	298	1	297	1.0e-36	147	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448296	128	53.6	2	126	1	124	2.0e-26	111	COG2363	Uncharacterized membrane protein YgdD, TMEM256/DUF423 family	124
646448297	366	77.25	1	356	1	356	0.0e+00	595	COG2933	23S rRNA C2498 (ribose-2'-O)-methylase RlmM	358
646448298	253	37.21	4	246	12	267	1.0e-56	213	COG0258	5'-3' exonuclease	310
646448299	454	32.68	136	338	4	201	5.0e-45	175	COG1611	Predicted Rossmann fold nucleotide-binding protein	205
646448301	106	48.08	1	104	1	104	9.0e-28	115	COG3098	Uncharacterized conserved protein YqcC, DUF446 family	109
646448302	261	37.44	2	225	78	289	3.0e-54	205	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646448303	150	32.03	1	148	1	151	3.0e-24	104	COG0716	Flavodoxin	151
646448305	274	56.79	1	273	1	271	1.0e-88	319	COG2171	Tetrahydrodipicolinate N-succinyltransferase	271
646448306	894	59.45	24	891	2	866	0.0e+00	1120	COG2844	UTP:GlnB (protein PII) uridylyltransferase	867
646448307	264	53.12	1	254	1	255	1.0e-97	349	COG0024	Methionine aminopeptidase	255
646448308	241	63.83	1	235	1	234	1.0e-99	355	COG0052	Ribosomal protein S2	252
646448309	285	60.14	1	284	1	296	1.0e-94	339	COG0264	Translation elongation factor EF-Ts	296
646448310	243	61.76	5	241	1	238	2.0e-93	335	COG0528	Uridylate kinase	238
646448311	185	62.7	1	185	3	187	9.0e-68	249	COG0233	Ribosome recycling factor	187
646448312	397	59.6	1	395	1	382	0.0e+00	557	COG0743	1-deoxy-D-xylulose 5-phosphate reductoisomerase	385
646448313	253	55.7	9	245	9	245	4.0e-91	327	COG0020	Undecaprenyl pyrophosphate synthase	245
646448314	285	35.46	1	281	1	264	8.0e-40	157	COG0575	CDP-diglyceride synthetase	265
646448315	451	37.64	5	451	2	373	6.0e-56	211	COG0750	Membrane-associated protease RseP, regulator of RpoE activity	375
646448316	805	45.85	1	805	1	766	0.0e+00	772	COG4775	Outer membrane protein assembly factor BamA	766
646448317	165	50.6	1	165	1	168	8.0e-26	109	COG2825	Periplasmic chaperone for outer membrane proteins, Skp family	170
646448318	341	56.34	1	338	1	338	2.0e-110	392	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	338
646448319	151	59.86	7	151	3	147	4.0e-49	187	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
646448320	262	62.31	3	262	1	260	5.0e-112	397	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	260
646448321	382	54.5	5	379	1	378	0.0e+00	483	COG0763	Lipid A disaccharide synthetase	381
646448322	198	60.53	13	198	2	191	9.0e-69	252	COG0164	Ribonuclease HII	199
646448323	1160	52.23	3	1158	1	1139	0.0e+00	1410	COG0587	DNA polymerase III, alpha subunit	1139
646448324	319	67.92	2	319	1	315	0.0e+00	510	COG0825	Acetyl-CoA carboxylase alpha subunit	317
646448325	129	27.54	7	128	3	138	2.0e-10	57.9	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646448326	448	31.07	5	305	4	298	4.0e-47	182	COG0037	tRNA(Ile)-lysidine synthase TilS/MesJ	298
646448327	86	63.86	3	85	1	83	4.0e-26	109	COG4568	Transcriptional antiterminator Rof (Rho-off)	84
646448329	182	61.8	1	178	1	178	1.0e-68	252	COG4681	Uncharacterized conserved protein YaeQ, suppresses RfaH defect	181
646448331	852	53.74	5	849	1	842	0.0e+00	1028	COG0249	DNA mismatch repair ATPase MutS	843
646448332	561	33.77	157	510	31	408	1.0e-48	187	COG0840	Methyl-accepting chemotaxis protein	408
646448333	296	28.2	5	296	1	304	1.0e-45	176	COG1893	Ketopantoate reductase	307
646448334	282	30	164	282	1	120	2.0e-13	69.9	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646448335	193	41.18	21	190	14	173	4.0e-36	144	COG1881	Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family	174
646448337	186	25.57	11	185	7	181	5.0e-22	97.7	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646448339	222	30.81	9	214	3	210	1.0e-23	103	COG3482	Uncharacterized protein	237
646448340	384	27.61	1	384	3	387	4.0e-36	145	COG1944	Ribosomal protein S12 methylthiotransferase accessory factor YcaO	398
646448341	1005	31.82	354	901	3	552	4.0e-96	346	COG2192	Predicted carbamoyl transferase, NodU family	555
646448345	361	44.44	115	345	3	236	1.0e-61	230	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
646448348	113	70.27	2	112	1	111	7.0e-45	172	COG2824	Uncharacterized Zn-ribbon-containing protein	112
646448349	241	41.01	62	232	1	178	1.0e-37	149	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646448352	414	22.03	125	410	89	365	2.0e-13	70.9	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
646448354	176	42.6	4	171	2	169	3.0e-44	171	COG1247	L-amino acid N-acyltransferase YncA	169
646448355	423	19.37	74	423	63	391	9.0e-08	51.7	COG2814	Predicted arabinose efflux permease, MFS family	394
646448356	475	22.94	16	457	12	409	4.0e-33	136	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646448357	316	30.46	1	300	1	297	1.0e-30	127	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448358	218	32.71	1	213	5	202	1.0e-36	146	COG0560	Phosphoserine phosphatase	212
646448359	366	24.02	8	361	2	327	2.0e-49	190	COG0620	Methionine synthase II (cobalamin-independent)	330
646448360	348	42.15	12	345	6	346	9.0e-88	317	COG0252	L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D	351
646448361	173	40	1	169	1	167	3.0e-44	171	COG0703	Shikimate kinase	172
646448362	94	71.28	1	94	1	94	7.0e-35	138	COG3123	Uncharacterized conserved protein YaiE, UPF0345 family	94
646448363	596	36.6	275	596	64	408	1.0e-48	188	COG0840	Methyl-accepting chemotaxis protein	408
646448364	303	70.53	2	303	1	302	4.0e-129	454	COG2974	DNA recombination-dependent growth factor C	303
646448365	303	35.6	1	299	7	305	8.0e-57	214	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646448366	1227	22.68	1	769	1	737	2.0e-40	161	COG0419	DNA repair exonuclease SbcCD ATPase subunit	908
646448367	410	27.56	1	402	1	388	7.0e-61	228	COG0420	DNA repair exonuclease SbcCD nuclease subunit	390
646448368	229	47.37	4	227	2	227	6.0e-63	234	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646448369	440	32.64	98	422	111	447	2.0e-47	183	COG5002	Signal transduction histidine kinase	459
646448370	324	35.14	7	301	17	318	5.0e-51	194	COG0226	ABC-type phosphate transport system, periplasmic component	318
646448371	371	24.93	5	365	2	325	4.0e-62	232	COG0620	Methionine synthase II (cobalamin-independent)	330
646448372	439	53.6	4	432	1	431	2.0e-126	446	COG1114	Branched-chain amino acid permeases	431
646448373	456	53.64	4	456	1	452	0.0e+00	528	COG1113	L-asparagine transporter and related permeases	462
646448374	358	34.32	8	342	1	325	8.0e-58	217	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646448375	396	26.79	20	393	40	382	4.0e-36	145	COG1680	CubicO group peptidase, beta-lactamase class C family	390
646448376	303	38.51	3	288	2	287	5.0e-38	151	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448378	200	58.16	1	196	2	194	1.0e-75	276	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	194
646448379	201	61.66	1	193	1	193	3.0e-68	251	COG3124	Acyl carrier protein phosphodiesterase	193
646448380	355	60.34	1	349	1	348	0.0e+00	525	COG0809	S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)	348
646448381	387	66.49	3	372	1	369	0.0e+00	587	COG0343	Queuine/archaeosine tRNA-ribosyltransferase	372
646448382	111	44.9	14	111	1	97	1.0e-26	111	COG1862	Preprotein translocase subunit YajC	97
646448383	604	52.11	64	604	1	506	0.0e+00	480	COG0342	Preprotein translocase subunit SecD	506
646448384	323	50.16	8	314	1	304	1.0e-91	330	COG0341	Preprotein translocase subunit SecF	305
646448386	903	34.74	30	903	7	917	0.0e+00	712	COG0474	Magnesium-transporting ATPase (P-type)	917
646448387	149	59.73	1	149	1	149	6.0e-57	213	COG1327	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains	156
646448388	370	74.66	1	146	1	146	6.0e-67	248	COG0117	Pyrimidine deaminase domain of riboflavin biosynthesis protein RibD	146
646448389	157	62.91	1	151	1	150	6.0e-53	200	COG0054	6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)	152
646448390	139	53.79	2	139	6	150	3.0e-38	150	COG0781	Transcription termination factor NusB	151
646448391	324	51.54	1	322	1	317	5.0e-98	351	COG0611	Thiamine monophosphate kinase	317
646448392	169	50.32	15	166	8	160	1.0e-40	159	COG1267	Phosphatidylglycerophosphatase A	160
646448393	620	63.34	8	620	2	623	0.0e+00	976	COG1154	Deoxyxylulose-5-phosphate synthase	627
646448394	303	38.02	3	303	2	322	1.0e-65	243	COG0142	Geranylgeranyl pyrophosphate synthase	322
646448395	82	51.9	2	80	3	81	2.0e-12	64.2	COG1722	Exonuclease VII small subunit	81
646448396	482	41.19	1	384	2	383	6.0e-116	411	COG0301	Adenylyl- and sulfurtransferase ThiI, participates in tRNA 4-thiouridine and thiamine biosynthesis	383
646448397	198	32.28	1	178	1	188	3.0e-26	111	COG0693	Putative intracellular protease/amidase	188
646448398	306	38.39	1	299	1	307	8.0e-63	234	COG1893	Ketopantoate reductase	307
646448399	163	74.23	1	163	4	165	2.0e-62	231	COG1666	Uncharacterized conserved protein YajQ, UPF0234 family	165
646448400	457	20.15	4	388	1	384	1.0e-22	101	COG2814	Predicted arabinose efflux permease, MFS family	394
646448401	297	44.48	1	290	16	303	1.0e-82	300	COG0109	Polyprenyltransferase (heme O synthase)	304
646448402	110	66.97	1	108	1	109	5.0e-25	106	COG3125	Heme/copper-type cytochrome/quinol oxidase, subunit 4	111
646448403	204	49	6	204	12	209	8.0e-52	196	COG1845	Heme/copper-type cytochrome/quinol oxidase, subunit 3	209
646448404	663	55.23	38	608	1	566	0.0e+00	632	COG0843	Heme/copper-type cytochrome/quinol oxidase, subunit 1	566
646448405	316	46.88	12	267	2	247	1.0e-70	260	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	247
646448406	489	23.69	77	399	75	382	7.0e-13	69.1	COG2814	Predicted arabinose efflux permease, MFS family	394
646448407	192	59.9	1	192	14	204	4.0e-60	224	COG3056	Uncharacterized lipoprotein YajG	204
646448408	104	57.65	1	84	3	87	1.0e-25	107	COG0271	Stress-induced morphogen (activity unknown)	90
646448409	434	48.18	1	430	1	439	3.0e-114	405	COG0544	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)	441
646448410	207	75.77	14	207	1	194	1.0e-89	322	COG0740	ATP-dependent protease ClpP, protease subunit	200
646448411	424	75.25	16	419	1	403	0.0e+00	713	COG1219	ATP-dependent protease Clp, ATPase subunit	408
646448412	787	71.92	2	778	1	780	0.0e+00	1243	COG0466	ATP-dependent Lon protease, bacterial type	782
646448413	90	62.22	1	90	2	91	9.0e-29	118	COG0776	Bacterial nucleoid DNA-binding protein	94
646448414	626	24.42	153	400	48	303	9.0e-07	48.9	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
646448416	231	50	1	213	2	211	6.0e-76	277	COG0603	7-cyano-7-deazaguanine synthase (queuosine biosynthesis)	222
646448417	350	28.03	13	322	2	300	1.0e-79	290	COG0031	Cysteine synthase	300
646448418	153	41.06	1	151	5	154	1.0e-37	148	COG1522	DNA-binding transcriptional regulator, Lrp family	154
646448419	588	37.63	1	574	1	567	3.0e-127	449	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
646448420	597	38.99	8	576	1	565	3.0e-120	426	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
646448421	112	66.96	1	112	1	112	2.0e-38	150	COG0347	Nitrogen regulatory protein PII	112
646448422	430	54.7	30	429	2	403	4.0e-117	415	COG0004	Ammonia channel protein AmtB	409
646448423	287	63.51	1	285	1	285	9.0e-114	403	COG1946	Acyl-CoA thioesterase	289
646448424	193	38.01	1	171	1	158	4.0e-28	117	COG3126	Uncharacterized lipoprotein YbaY	158
646448425	108	61.39	4	104	3	103	3.0e-32	130	COG3695	Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain	103
646448430	83	38.55	1	82	1	72	1.0e-16	78	COG0254	Ribosomal protein L31	75
646448431	1048	55.62	1	1029	2	1009	0.0e+00	1083	COG0841	Multidrug efflux pump subunit AcrB	1009
646448432	384	37.53	2	370	13	372	8.0e-40	158	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646448433	216	23.19	1	207	2	201	2.0e-13	69.7	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646448434	1137	42.41	237	1125	1	823	0.0e+00	728	COG3264	Small-conductance mechanosensitive channel	835
646448435	183	47.78	1	180	1	174	1.0e-25	109	COG3923	Primosomal replication protein N''	175
646448436	256	47.98	6	252	5	203	5.0e-67	247	COG4445	tRNA isopentenyl-2-thiomethyl-A-37 hydroxylase MiaE (synthesis of 2-methylthio-cis-ribozeatin)	203
646448437	122	47.9	1	118	1	119	3.0e-25	107	COG2832	Uncharacterized membrane protein YbaN, DUF454 family	119
646448438	182	51.96	3	181	1	179	2.0e-51	194	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	179
646448439	675	45.81	1	505	1	513	0.0e+00	483	COG2812	DNA polymerase III, gamma/tau subunits	515
646448440	109	58.88	1	106	1	105	9.0e-28	115	COG0718	Conserved DNA-binding protein YbaB (function unknown)	105
646448441	201	58.29	1	199	1	198	9.0e-85	306	COG0353	Recombinational DNA repair protein RecR	198
646448442	629	65.55	3	628	1	619	0.0e+00	887	COG0326	Molecular chaperone, HSP90 family	623
646448443	214	42.66	1	214	1	178	4.0e-50	191	COG0563	Adenylate kinase or related kinase	178
646448444	320	46.89	1	319	1	317	6.0e-107	380	COG0276	Protoheme ferro-lyase (ferrochelatase)	320
646448445	561	75.74	6	409	5	408	0.0e+00	522	COG4651	Predicted Kef-type K+ transport protein, K+/H+ antiporter domain	408
646448446	550	35.06	11	550	3	515	2.0e-99	356	COG0737	2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family	517
646448448	530	38.11	190	512	60	408	2.0e-46	180	COG0840	Methyl-accepting chemotaxis protein	408
646448449	159	57.59	1	158	1	155	3.0e-41	160	COG2606	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC	155
646448450	270	34.4	1	265	9	290	5.0e-54	204	COG3735	Uncharacterized conserved protein YbaP, TraB family	299
646448451	942	42.8	198	935	3	713	0.0e+00	712	COG2217	Cation transport ATPase	713
646448452	143	33.02	1	105	1	106	8.0e-22	96.3	COG0789	DNA-binding transcriptional regulator, MerR family	124
646448453	149	50	10	147	5	139	6.0e-27	113	COG1585	Membrane protein implicated in regulation of membrane protease activity	140
646448454	304	41.67	1	293	2	291	2.0e-53	203	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
646448455	86	27.96	1	85	2	94	7.0e-11	58.9	COG0633	Ferredoxin	102
646448456	376	35.83	2	371	1	346	2.0e-92	332	COG0208	Ribonucleotide reductase beta subunit, ferritin-like domain	348
646448457	762	35.3	41	745	1	648	0.0e+00	601	COG0209	Ribonucleotide reductase alpha subunit	696
646448458	252	59.32	17	249	6	240	2.0e-91	329	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	243
646448459	877	58.98	1	842	1	803	0.0e+00	1087	COG0188	DNA gyrase/topoisomerase IV, subunit A	804
646448460	962	36.44	463	708	97	335	7.0e-42	166	COG0642	Signal transduction histidine kinase	336
646448461	216	33.18	4	210	1	208	8.0e-40	157	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646448462	889	25.49	418	671	91	336	1.0e-21	99.1	COG0642	Signal transduction histidine kinase	336
646448463	441	40.28	9	436	4	419	4.0e-99	355	COG1169	Isochorismate synthase EntC	423
646448464	558	47.09	1	557	1	563	0.0e+00	624	COG1165	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	566
646448465	265	23.19	13	252	19	279	5.0e-13	68.6	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646448466	285	75.89	6	285	1	282	0.0e+00	525	COG0447	1,4-Dihydroxy-2-naphthoyl-CoA synthase	282
646448467	322	71.65	1	320	1	321	0.0e+00	490	COG1441	O-succinylbenzoate synthase	321
646448468	463	29.96	9	460	17	530	6.0e-73	268	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646448470	398	43.32	1	245	1	245	1.0e-69	257	COG1058	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	255
646448471	286	54.26	6	286	23	304	2.0e-82	299	COG3118	Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains	304
646448472	258	30.45	1	236	5	240	9.0e-40	157	COG0300	Short-chain dehydrogenase	265
646448473	223	34.88	31	223	1	215	7.0e-28	117	COG2755	Lysophospholipase L1 or related esterase	216
646448474	228	74.12	1	228	1	228	2.0e-93	334	COG4181	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component	228
646448475	810	48.91	1	808	6	829	0.0e+00	842	COG3127	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component	829
646448476	188	30.64	8	170	10	182	9.0e-23	100	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646448477	721	27.42	11	721	31	750	1.0e-64	241	COG4774	Outer membrane receptor for monomeric catechols	750
646448478	369	29.14	18	339	34	319	8.0e-41	161	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
646448479	281	46.08	57	272	6	222	3.0e-54	205	COG0765	ABC-type amino acid transport system, permease component	222
646448480	273	35.21	1	273	1	272	5.0e-35	141	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646448481	336	85.42	1	336	1	336	0.0e+00	485	COG4211	ABC-type glucose/galactose transport system, permease component	336
646448482	506	47.31	6	503	1	498	0.0e+00	650	COG1129	ABC-type sugar transport system, ATPase component	500
646448483	331	32.93	6	331	14	317	2.0e-40	160	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646448484	332	39.76	2	332	1	332	8.0e-87	313	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646448485	212	53.5	2	201	1	200	1.0e-80	292	COG0299	Folate-dependent phosphoribosylglycinamide formyltransferase PurN	200
646448486	345	66.18	4	344	1	343	0.0e+00	527	COG0150	Phosphoribosylaminoimidazole (AIR) synthetase	345
646448487	208	65.55	1	208	2	210	4.0e-81	293	COG0035	Uracil phosphoribosyltransferase	210
646448488	437	41.08	6	417	7	444	1.0e-84	307	COG2233	Xanthine/uracil permease	451
646448490	118	38.79	3	118	1	115	7.0e-32	129	COG1393	Arsenate reductase and related proteins, glutaredoxin family	117
646448491	487	50.1	1	486	1	484	0.0e+00	482	COG4783	Putative Zn-dependent protease, contains TPR repeats	484
646448492	155	52.29	1	153	1	153	2.0e-56	211	COG1225	Peroxiredoxin	157
646448493	189	59.09	4	179	1	176	6.0e-61	226	COG2716	Glycine cleavage system regulatory protein	176
646448494	292	50.34	1	292	4	297	3.0e-96	344	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646448495	346	50.73	6	344	1	342	5.0e-94	338	COG3317	Uncharacterized lipoprotein	342
646448496	237	54.39	1	237	1	239	1.0e-82	299	COG0152	Phosphoribosylaminoimidazole-succinocarboxamide synthase	247
646448497	150	59.18	4	150	2	148	1.0e-34	139	COG2707	Uncharacterized membrane protein, DUF441 family	151
646448498	672	33.01	4	661	21	736	0.0e+00	506	COG1444	tRNA(Met) C34 N-acetyltransferase TmcA	758
646448499	228	24.06	1	209	3	207	4.0e-28	118	COG0400	Predicted esterase	207
646448501	227	37.5	2	211	26	240	1.0e-43	169	COG1876	LD-carboxypeptidase LdcB, LAS superfamily	241
646448502	375	34.17	1	375	11	408	4.0e-85	308	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646448503	127	38.98	1	116	1	115	4.0e-30	123	COG1393	Arsenate reductase and related proteins, glutaredoxin family	117
646448504	69	71.64	3	69	1	67	9.0e-26	108	COG1278	Cold shock protein, CspA family	67
646448505	127	43.2	1	124	1	125	8.0e-22	96	COG0239	Fluoride ion exporter CrcB/FEX, affects chromosome condensation	126
646448507	262	36.53	1	262	3	271	4.0e-47	181	COG0388	Predicted amidohydrolase	274
646448509	321	66.34	13	321	1	306	0.0e+00	501	COG0320	Lipoate synthase	306
646448510	236	59.31	13	214	9	212	4.0e-80	291	COG0321	Lipoate-protein ligase B	221
646448511	87	75.28	1	87	2	90	4.0e-33	132	COG2921	Putative lipoic acid-binding regulatory protein	90
646448512	403	50.76	11	402	3	389	4.0e-118	418	COG1686	D-alanyl-D-alanine carboxypeptidase	389
646448513	382	34.2	5	229	7	232	4.0e-40	159	COG0797	Rare lipoprotein A, peptidoglycan hydrolase digesting "naked" glycans, contains C-terminal SPOR domain	233
646448514	370	44.89	11	370	9	379	6.0e-85	307	COG0772	Bacterial cell division protein FtsW, lipid II flippase	381
646448515	636	37.03	6	619	1	593	0.0e+00	491	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
646448516	156	52.26	1	155	1	155	6.0e-62	229	COG1576	23S rRNA pseudoU1915 N3-methylase RlmH	155
646448517	105	53.33	1	105	1	105	6.0e-37	145	COG0799	Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits	115
646448518	219	46.41	12	219	6	196	5.0e-57	214	COG1057	Nicotinic acid mononucleotide adenylyltransferase	197
646448519	343	36.23	4	334	1	333	1.0e-71	263	COG1466	DNA polymerase III, delta subunit	334
646448520	184	52.49	1	180	1	178	9.0e-48	183	COG2980	Outer membrane lipoprotein LptE/RlpB (LPS assembly)	178
646448521	860	52.89	1	859	1	814	0.0e+00	1107	COG0495	Leucyl-tRNA synthetase	814
646448523	241	63.75	1	240	2	240	1.0e-109	389	COG1126	ABC-type polar amino acid transport system, ATPase component	240
646448524	224	42.41	2	222	1	217	5.0e-48	184	COG0765	ABC-type amino acid transport system, permease component	222
646448525	246	33.91	9	241	2	222	1.0e-46	179	COG0765	ABC-type amino acid transport system, permease component	222
646448526	297	29.64	3	276	1	273	7.0e-36	144	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646448527	509	41.73	1	509	5	514	1.0e-121	430	COG0815	Apolipoprotein N-acyltransferase	518
646448528	289	77.05	1	289	1	292	2.0e-121	428	COG4535	Mg2+ and Co2+ transporter CorC, contains CBS pair and CorC-HlyC domains	293
646448529	161	49.02	4	153	1	153	8.0e-41	159	COG0319	ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme	153
646448530	351	55.52	7	340	15	348	1.0e-122	433	COG1702	Phosphate starvation-inducible protein PhoH, predicted ATPase	348
646448531	476	51.13	3	442	1	436	0.0e+00	558	COG0621	tRNA A37 methylthiotransferase MiaB	437
646448532	388	33.08	1	388	1	385	4.0e-80	291	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
646448533	109	47.12	1	104	2	105	4.0e-21	92.8	COG2076	Multidrug transporter EmrE and related cation transporters	106
646448540	554	37.39	1	553	1	542	0.0e+00	485	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	542
646448541	407	30.37	82	406	2	314	6.0e-52	198	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646448542	383	53.39	1	381	1	380	1.0e-130	460	COG1820	N-acetylglucosamine-6-phosphate deacetylase	380
646448543	266	40.8	1	249	1	238	8.0e-65	240	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	238
646448544	490	34.7	1	403	3	393	4.0e-71	262	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
646448545	552	35.44	20	529	1	472	8.0e-115	407	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	472
646448546	148	49.31	1	144	5	145	2.0e-38	151	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
646448547	175	46.47	1	168	1	151	8.0e-34	136	COG0716	Flavodoxin	151
646448548	562	36.36	136	517	2	408	8.0e-52	198	COG0840	Methyl-accepting chemotaxis protein	408
646448550	260	26.05	22	260	23	282	2.0e-19	89.4	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646448551	178	69.61	1	178	1	181	2.0e-69	254	COG3057	Negative regulator of replication initiation	181
646448552	547	68.7	25	547	1	524	0.0e+00	769	COG0033	Phosphoglucomutase	524
646448553	142	48.23	1	141	1	139	3.0e-23	101	COG2510	Uncharacterized membrane protein	140
646448554	229	43.61	7	229	2	227	4.0e-57	214	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646448555	909	52.1	4	906	1	889	0.0e+00	1051	COG2205	K+-sensing histidine kinase KdpD	890
646448556	191	58.2	1	187	2	190	3.0e-61	227	COG2156	K+-transporting ATPase, c chain	190
646448557	688	73.44	3	688	2	681	0.0e+00	1061	COG2216	High-affinity K+ transport system, ATPase chain B	681
646448558	561	65.29	6	556	5	559	0.0e+00	719	COG2060	K+-transporting ATPase, A chain	560
646448560	319	66.67	158	319	1	161	1.0e-59	223	COG3272	Uncharacterized conserved protein YbgA, DUF1722 family	163
646448561	481	51.06	1	471	1	461	0.0e+00	522	COG0415	Deoxyribodipyrimidine photolyase	461
646448562	247	42	1	247	1	250	6.0e-70	257	COG0327	Putative GTP cyclohydrolase 1 type 2, NIF3 family	250
646448563	219	51.85	6	219	1	216	9.0e-71	259	COG2049	Allophanate hydrolase subunit 1	223
646448564	309	53.04	2	309	1	313	2.0e-113	402	COG1984	Allophanate hydrolase subunit 2	314
646448565	245	61.45	1	244	2	250	5.0e-92	330	COG1540	Lactam utilization protein B (function unknown)	252
646448566	428	54.52	27	423	1	386	0.0e+00	499	COG0372	Citrate synthase	390
646448567	129	46.46	7	129	1	127	4.0e-17	80.3	COG2009	Succinate dehydrogenase/fumarate reductase, cytochrome b subunit	132
646448568	115	45.22	1	115	2	116	4.0e-19	86.8	COG2142	Succinate dehydrogenase, hydrophobic anchor subunit	117
646448569	588	55.19	3	573	2	561	0.0e+00	656	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	562
646448570	238	55.46	1	237	1	231	2.0e-84	305	COG0479	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit	234
646448571	935	65.45	6	934	1	906	0.0e+00	1453	COG0567	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	906
646448572	406	50.98	2	405	1	404	2.0e-118	419	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	404
646448573	388	65.13	1	388	1	387	0.0e+00	553	COG0045	Succinyl-CoA synthetase, beta subunit	387
646448574	290	70.93	1	288	1	289	7.0e-124	436	COG0074	Succinyl-CoA synthetase, alpha subunit	293
646448577	379	49.21	1	374	1	346	1.0e-91	330	COG1294	Cytochrome bd-type quinol oxidase, subunit 2	346
646448578	37	57.14	1	35	1	35	8.0e-06	42	COG4890	Predicted outer membrane lipoprotein	37
646448579	96	62.11	2	96	3	97	3.0e-28	116	COG3790	Predicted membrane protein, encoded in cydAB operon	97
646448580	134	41.04	1	134	1	133	3.0e-32	130	COG0824	Acyl-CoA thioesterase FadM	137
646448581	228	43.52	9	224	1	216	1.0e-51	196	COG0811	Biopolymer transport protein ExbB/TolQ	216
646448582	141	38.3	1	141	2	135	5.0e-28	116	COG0848	Biopolymer transport protein ExbD	137
646448583	399	52.38	1	398	1	387	7.0e-18	85.2	COG3064	Membrane protein involved in colicin uptake	387
646448584	428	50.35	9	428	1	425	1.0e-114	406	COG0823	Periplasmic component of the Tol biopolymer transport system	425
646448585	168	33.51	1	168	3	187	5.0e-36	143	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
646448586	270	47.79	1	270	1	261	6.0e-59	221	COG1729	Periplasmic TolA-binding protein (function unknown)	262
646448589	239	35.71	1	238	1	227	2.0e-39	155	COG1811	Uncharacterized membrane protein YqgA, affects biofilm formation	228
646448590	349	47.49	8	345	1	324	5.0e-116	411	COG0379	Quinolinate synthase	324
646448591	241	40.93	4	239	8	222	4.0e-44	171	COG3201	Nicotinamide riboside transporter PnuC	222
646448592	350	69.14	1	349	1	350	0.0e+00	598	COG0722	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	351
646448593	250	65.65	3	232	1	230	9.0e-102	363	COG0588	Phosphoglycerate mutase (BPG-dependent)	230
646448594	1042	51.25	1	1039	1	1022	0.0e+00	1235	COG3696	Cu/Ag efflux pump CusA	1027
646448595	503	25.38	91	390	30	356	3.0e-18	87.1	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646448596	419	19.13	22	418	37	448	7.0e-11	62.1	COG1538	Outer membrane protein TolC	457
646448597	134	32.58	45	131	23	108	3.0e-09	54.3	COG5569	Periplasmic Cu and Ag efflux protein CusF	108
646448599	356	37.35	16	350	6	305	4.0e-55	208	COG2017	Galactose mutarotase or related enzyme	308
646448600	383	55.78	1	383	3	390	0.0e+00	490	COG0153	Galactokinase	390
646448601	356	57.31	9	346	1	338	4.0e-120	424	COG1085	Galactose-1-phosphate uridylyltransferase	338
646448602	338	48.82	1	336	1	329	0.0e+00	488	COG1087	UDP-glucose 4-epimerase	329
646448603	489	50.78	230	486	1	257	2.0e-84	306	COG1119	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA	257
646448604	263	59.23	1	130	1	130	3.0e-41	162	COG2005	DNA-binding transcriptional regulator ModE (molybdenum-dependent)	130
646448606	261	42.97	9	256	12	256	1.0e-59	223	COG0725	ABC-type molybdate transport system, periplasmic component	258
646448607	229	59.29	3	228	1	225	3.0e-69	255	COG4149	ABC-type molybdate transport system, permease component	225
646448608	352	69.6	1	352	1	352	0.0e+00	499	COG4148	ABC-type molybdate transport system, ATPase component	352
646448609	273	33.46	1	268	1	258	4.0e-54	204	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
646448610	331	44.41	1	329	1	346	8.0e-99	353	COG2706	6-phosphogluconolactonase, cycloisomerase 2 family	346
646448611	416	46.47	6	416	8	370	3.0e-122	432	COG5276	Uncharacterized conserved protein	370
646448612	358	21.81	14	306	6	297	1.0e-22	100	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646448614	676	42.78	2	548	1	558	0.0e+00	683	COG0143	Methionyl-tRNA synthetase	558
646448616	369	42.45	49	323	3	265	1.0e-59	224	COG0489	Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster	265
646448617	213	56.34	1	213	1	209	1.0e-75	276	COG0572	Uridine kinase	218
646448618	193	47.67	1	192	1	183	1.0e-52	199	COG0717	Deoxycytidine triphosphate deaminase	183
646448619	604	25.48	1	596	4	621	1.0e-57	217	COG2982	Uncharacterized protein involved in outer membrane biogenesis	648
646448620	529	50.62	1	237	8	248	1.0e-70	260	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
646448621	378	48.12	48	286	9	239	1.0e-54	207	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
646448622	144	37.76	1	142	1	138	8.0e-31	126	COG0394	Protein-tyrosine-phosphatase	139
646448623	723	29.65	15	455	9	458	1.0e-56	215	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
646448624	384	18.92	2	383	1	379	5.0e-18	85.5	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448625	400	17.32	2	387	1	381	5.0e-15	75.8	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448626	344	25.34	52	343	86	375	6.0e-29	121	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646448628	468	44.4	238	468	1	226	3.0e-71	262	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
646448629	354	66.57	1	352	1	338	0.0e+00	580	COG1088	dTDP-D-glucose 4,6-dehydratase	340
646448630	289	59.09	1	286	1	283	2.0e-117	415	COG1209	dTDP-glucose pyrophosphorylase	286
646448631	178	63.43	1	175	1	173	1.0e-61	229	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	173
646448632	285	50.7	1	285	1	281	1.0e-90	326	COG1091	dTDP-4-dehydrorhamnose reductase	281
646448634	423	20.33	1	421	2	422	3.0e-16	80.1	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
646448635	278	19.8	1	276	2	285	4.0e-06	45.5	COG1216	Glycosyltransferase, GT2 family	305
646448636	475	52.08	4	337	2	332	0.0e+00	461	COG0836	Mannose-1-phosphate guanylyltransferase	333
646448637	457	38.66	1	456	4	459	5.0e-109	388	COG1109	Phosphomannomutase	464
646448638	335	29.86	1	335	1	314	7.0e-53	201	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646448639	388	40	1	388	1	414	8.0e-126	443	COG1004	UDP-glucose 6-dehydrogenase	414
646448640	299	50.17	1	299	2	291	5.0e-98	350	COG1210	UTP-glucose-1-phosphate uridylyltransferase	291
646448641	468	70.43	1	468	1	469	0.0e+00	815	COG0362	6-phosphogluconate dehydrogenase	473
646448649	354	33.71	178	354	4	181	4.0e-36	145	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646448650	298	29.19	85	290	15	219	2.0e-19	90.2	COG1802	DNA-binding transcriptional regulator, GntR family	230
646448652	259	36.59	21	259	7	251	5.0e-42	164	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646448653	316	35.62	1	304	7	300	4.0e-54	205	COG2990	Uncharacterized protein VirK/YbjX	300
646448655	161	46.36	11	161	6	156	2.0e-41	161	COG0783	DNA-binding ferritin-like protein (oxidative damage protectant)	156
646448657	485	26.62	205	464	1	233	2.0e-47	183	COG0775	Nucleoside phosphorylase	234
646448658	172	45.93	1	172	1	160	1.0e-50	192	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
646448659	678	42.75	1	542	6	547	0.0e+00	532	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
646448660	455	42.86	1	100	1	98	2.0e-12	67.7	COG4104	Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, incolved in TypeVI secretion	98
646448665	1657	21.3	822	1564	2	691	3.0e-36	148	COG3209	Uncharacterized conserved protein RhaS, contains 28 RHS repeats	796
646448673	385	47.12	6	382	9	389	3.0e-115	408	COG1473	Metal-dependent amidase/aminoacylase/carboxypeptidase	392
646448674	167	47.83	9	167	9	168	2.0e-43	168	COG3516	Predicted component of the type VI protein secretion system	169
646448675	492	55.47	1	492	4	493	0.0e+00	727	COG3517	Predicted component of the type VI protein secretion system	495
646448676	143	32.88	7	141	7	152	8.0e-20	89.6	COG3518	Predicted component of the type VI protein secretion system	157
646448677	588	38.03	1	585	3	618	0.0e+00	515	COG3519	Type VI protein secretion system component VasA	621
646448678	337	44.59	21	333	17	328	8.0e-82	297	COG3520	Predicted component of the type VI protein secretion system	335
646448679	404	35.96	7	401	3	428	1.0e-67	250	COG3456	Predicted component of the type VI protein secretion system, contains a FHA domain	430
646448680	178	32.34	11	176	9	159	8.0e-31	126	COG3521	Predicted component of the type VI protein secretion system	159
646448681	445	53.14	1	444	1	446	0.0e+00	513	COG3522	Predicted component of the type VI protein secretion system	446
646448682	258	45.73	27	257	26	259	3.0e-63	235	COG3455	Type VI protein secretion system component VasF	262
646448683	866	39.26	12	865	1	784	0.0e+00	744	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
646448686	478	24.28	205	478	13	285	6.0e-15	75.9	COG3515	Predicted component of the type VI protein secretion system	346
646448687	1165	34.12	18	1165	13	1188	0.0e+00	802	COG3523	Type VI protein secretion system component VasK	1188
646448689	456	25.09	152	432	40	282	2.0e-10	60.8	COG0790	TPR repeat	292
646448691	286	36.49	3	281	2	281	1.0e-56	213	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
646448692	336	32.22	1	305	3	328	2.0e-40	159	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646448693	330	39.03	24	328	31	333	1.0e-69	257	COG3367	Uncharacterized conserved protein, NAD-dependent epimerase/dehydratase family	339
646448695	281	40.6	1	267	7	304	5.0e-47	181	COG0672	High-affinity Fe2+/Pb2+ permease	383
646448696	373	68.62	1	373	1	376	0.0e+00	481	COG2822	Iron uptake system EfeUOB, periplasmic (or lipoprotein) component EfeO/EfeM	376
646448697	437	43.24	63	437	13	352	2.0e-91	329	COG2837	Periplasmic deferrochelatase/peroxidase EfeB	352
646448698	75	80.82	1	73	1	73	4.0e-24	102	COG3813	Uncharacterized protein	84
646448699	501	21.71	65	451	52	394	2.0e-12	67.5	COG2814	Predicted arabinose efflux permease, MFS family	394
646448702	297	30.61	5	294	2	288	2.0e-36	146	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448703	383	35.97	2	363	1	358	5.0e-82	298	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646448704	134	24.41	1	126	1	126	7.0e-08	49.6	COG4319	Ketosteroid isomerase homolog	137
646448706	1044	50.34	1	1024	2	1009	0.0e+00	963	COG0841	Multidrug efflux pump subunit AcrB	1009
646448707	420	30.61	33	406	1	368	3.0e-34	139	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646448708	248	41.63	18	246	3	227	3.0e-49	188	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646448709	358	35.81	66	358	46	334	2.0e-36	146	COG0642	Signal transduction histidine kinase	336
646448710	315	31.06	7	297	1	289	1.0e-36	147	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448711	140	23.4	5	123	3	138	4.0e-07	47.5	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646448712	254	31.2	6	252	4	252	2.0e-13	69.7	COG0730	Uncharacterized membrane protein YfcA	258
646448713	580	34.8	2	488	1	513	4.0e-97	349	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646448714	231	41.56	1	231	1	218	1.0e-53	203	COG1556	L-lactate utilization protein LutC, contains LUD domain	218
646448715	475	54.94	4	464	1	459	0.0e+00	624	COG1139	L-lactate utilization protein LutB, contains a ferredoxin-type domain	459
646448717	382	49.82	97	372	1	283	2.0e-95	343	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	283
646448718	265	38.79	151	265	3	118	3.0e-20	92.6	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646448719	231	56.19	1	226	3	228	2.0e-69	255	COG1346	Putative effector of murein hydrolase	230
646448720	138	45.31	5	132	1	128	3.0e-26	110	COG1380	Putative effector of murein hydrolase LrgA, UPF0299 family	128
646448721	217	57.5	12	211	1	200	1.0e-69	256	COG4566	Two-component response regulator, FixJ family, consists of REC and HTH domains	202
646448723	441	47.54	16	258	3	238	4.0e-79	289	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
646448724	584	42.75	63	583	2	523	0.0e+00	498	COG4986	ABC-type anion transport system, duplicated permease component	523
646448725	733	78.31	1	733	12	730	0.0e+00	1255	COG0376	Catalase (peroxidase I)	730
646448726	566	35.05	3	563	1	598	2.0e-118	420	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
646448728	530	29.96	1	529	6	552	1.0e-76	281	COG0747	ABC-type transport system, periplasmic component	556
646448729	311	43.53	1	307	1	314	4.0e-72	265	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646448730	285	40.22	1	274	9	284	5.0e-60	224	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646448731	270	41.11	6	270	1	270	2.0e-77	282	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
646448732	253	44.36	1	253	2	249	2.0e-66	245	COG1124	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	252
646448733	157	23.39	18	140	2	124	2.0e-12	65.7	COG1846	DNA-binding transcriptional regulator, MarR family	126
646448734	390	41.47	4	342	4	343	2.0e-82	299	COG1566	Multidrug resistance efflux pump	352
646448736	299	38.38	15	113	24	122	9.0e-22	97.6	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646448738	196	21.81	2	186	6	173	4.0e-18	85	COG1853	NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family	176
646448739	110	40.4	6	104	4	98	9.0e-28	115	COG3615	Uncharacterized protein/domain, possibly involved in tellurite resistance	99
646448742	5390	28.35	2876	3931	6	996	0.0e+00	536	COG3321	Acyl transferase domain in polyketide synthase (PKS) enzymes	1061
646448743	329	26.76	1	325	1	312	8.0e-36	144	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646448744	414	36.26	56	407	37	387	2.0e-83	302	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
646448746	630	41.72	1	280	1	290	6.0e-68	252	COG0331	Malonyl CoA-acyl carrier protein transacylase	310
646448747	2304	36.94	1124	1784	1	642	7.0e-123	436	COG1020	Non-ribosomal peptide synthetase component F	642
646448748	1163	39.79	329	991	1	642	0.0e+00	480	COG1020	Non-ribosomal peptide synthetase component F	642
646448749	1930	35.26	333	995	1	642	3.0e-117	417	COG1020	Non-ribosomal peptide synthetase component F	642
646448750	426	32.32	37	421	38	407	2.0e-67	250	COG2124	Cytochrome P450	411
646448751	421	21.99	1	410	2	390	3.0e-34	139	COG1819	UDP:flavonoid glycosyltransferase YjiC, YdhE family	406
646448752	239	27.14	10	193	1	210	4.0e-21	95.3	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646448753	180	28.57	29	172	13	156	1.0e-17	82.8	COG2030	Acyl dehydratase	159
646448754	471	35.91	15	453	12	447	3.0e-65	242	COG0534	Na+-driven multidrug efflux pump	455
646448762	300	32.32	9	299	2	290	4.0e-37	148	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448763	338	35.14	5	336	1	325	1.0e-59	223	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646448764	101	27.06	1	85	3	87	8.0e-10	55.4	COG1359	Quinol monooxygenase YgiN	100
646448765	130	25	5	127	1	137	2.0e-10	58.3	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646448766	308	23.96	25	303	3	282	9.0e-17	81.3	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646448767	191	30.65	12	189	10	190	8.0e-21	93.6	COG5516	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding	196
646448768	188	21.62	1	183	6	190	2.0e-10	58.9	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646448769	158	71.71	7	158	3	154	2.0e-64	238	COG3558	Uncharacterized conserved protein, nuclear transport factor 2 (NTF2) superfamily	154
646448770	245	29.06	1	201	1	196	1.0e-31	130	COG0518	GMP synthase - Glutamine amidotransferase domain	198
646448771	255	30.51	139	255	1	118	2.0e-14	73.4	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646448773	318	32.64	1	318	3	325	7.0e-45	174	COG2070	NAD(P)H-dependent flavin oxidoreductase YrpB, nitropropane dioxygenase family	336
646448774	289	28.04	1	288	1	294	9.0e-37	147	COG0583	DNA-binding transcriptional regulator, LysR family	297
646448776	469	29.07	27	453	13	439	1.0e-41	164	COG0534	Na+-driven multidrug efflux pump	455
646448777	494	37.47	13	487	1	457	2.0e-54	207	COG1538	Outer membrane protein TolC	457
646448778	205	19.9	8	203	2	197	8.0e-10	57.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646448779	372	28.73	1	360	5	370	2.0e-18	87.1	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646448780	1021	28.46	7	1015	1	1009	0.0e+00	813	COG0841	Multidrug efflux pump subunit AcrB	1009
646448781	268	29.2	1	265	3	260	2.0e-43	169	COG0300	Short-chain dehydrogenase	265
646448782	428	51.89	5	426	1	412	6.0e-124	437	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646448783	268	41.85	2	184	6	189	6.0e-41	161	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
646448786	333	38.64	1	331	1	325	3.0e-67	249	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646448787	363	43.01	1	360	1	360	5.0e-91	328	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646448788	260	36.88	1	259	3	265	4.0e-65	241	COG0300	Short-chain dehydrogenase	265
646448789	372	38.64	9	355	6	334	4.0e-81	295	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646448790	124	33.33	12	122	10	120	6.0e-24	102	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646448791	336	34.78	242	332	28	119	3.0e-14	73	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646448792	268	32.14	1	187	5	200	1.0e-35	143	COG0300	Short-chain dehydrogenase	265
646448795	297	23.31	31	261	5	237	8.0e-20	91.1	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646448796	262	34.41	1	243	4	249	8.0e-36	144	COG1024	Enoyl-CoA hydratase/carnithine racemase	257
646448797	298	21	7	298	23	299	2.0e-12	66.7	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
646448798	206	28.26	13	196	4	174	1.0e-26	113	COG1853	NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family	176
646448802	297	34.44	65	296	74	312	4.0e-35	142	COG0657	Acetyl esterase/lipase	312
646448803	327	23.79	82	308	15	220	4.0e-14	72.6	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646448804	161	33.93	5	116	7	116	3.0e-17	81.2	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646448805	204	20.62	1	193	6	199	5.0e-13	67.8	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646448806	293	30.47	13	256	2	255	9.0e-24	104	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
646448808	209	42.79	1	208	3	208	8.0e-30	123	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
646448809	165	47.1	7	161	1	154	2.0e-34	138	COG1522	DNA-binding transcriptional regulator, Lrp family	154
646448810	284	34.67	60	284	20	229	1.0e-22	100	COG2801	Transposase InsO and inactivated derivatives	232
646448814	78	43.75	1	78	1	80	5.0e-12	62.8	COG5302	Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid	80
646448816	167	32.69	5	155	11	163	7.0e-19	87	COG4282	Cell wall assembly regulator SMI1	191
646448820	620	17.71	21	527	9	529	2.0e-08	55	COG3505	Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase	596
646448822	338	28.12	1	311	3	292	9.0e-44	170	COG0630	Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase	312
646448823	402	23.12	30	396	4	360	9.0e-35	141	COG2948	Type IV secretory pathway, VirB10 components	360
646448824	296	19.01	21	281	27	245	2.0e-17	83.1	COG3504	Type IV secretory pathway, VirB9 components	265
646448825	227	30.77	6	223	20	232	1.0e-29	123	COG3736	Type IV secretory pathway, component VirB8	239
646448826	342	20.23	32	339	72	406	6.0e-06	45.4	COG3704	Type IV secretory pathway, VirB6 components	406
646448829	915	32.67	112	911	18	788	0.0e+00	461	COG3451	Type IV secretory pathway, VirB4 component	796
646448836	64	55.74	1	61	8	68	1.0e-16	78	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
646448839	89	64.94	4	80	6	82	2.0e-23	100	COG3423	Predicted transcriptional regulator, lambda repressor-like DNA-binding domain	82
646448841	172	44.77	1	172	1	160	2.0e-50	191	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
646448842	617	43.51	1	544	6	550	0.0e+00	556	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
646448843	135	36.5	1	131	3	139	7.0e-27	112	COG5435	Uncharacterized protein	147
646448844	1426	22.25	561	1311	11	669	4.0e-35	144	COG3209	Uncharacterized conserved protein RhaS, contains 28 RHS repeats	796
646448844	1426	41.89	115	187	25	97	6.0e-10	61.1	COG4104	Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, incolved in TypeVI secretion	98
646448847	103	56.6	1	103	3	107	2.0e-32	130	COG5489	Uncharacterized conserved protein, DUF736 family	107
646448848	427	20.13	103	401	27	309	6.0e-10	58.8	COG0582	Integrase	309
646448851	467	52.99	17	467	11	458	0.0e+00	524	COG1113	L-asparagine transporter and related permeases	462
646448854	218	41.71	2	211	1	211	3.0e-53	201	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646448855	610	51.49	5	608	3	581	0.0e+00	688	COG0322	Excinuclease UvrABC, nuclease subunit	581
646448856	182	41.21	1	181	10	190	2.0e-28	118	COG0558	Phosphatidylglycerophosphate synthase	192
646448861	163	40.88	7	163	29	179	4.0e-33	134	COG4678	Muramidase (phage lambda lysozyme)	180
646448865	125	37.11	26	122	3	98	4.0e-08	50.4	COG3783	Soluble cytochrome b562	100
646448866	478	32.6	20	476	6	455	5.0e-66	245	COG0534	Na+-driven multidrug efflux pump	455
646448869	572	39.56	192	530	45	408	1.0e-50	194	COG0840	Methyl-accepting chemotaxis protein	408
646448875	295	48.24	1	284	3	265	2.0e-72	266	COG1291	Flagellar motor component MotA	266
646448876	376	37.55	7	265	1	244	1.0e-53	204	COG1360	Flagellar motor protein MotB	244
646448877	678	44.57	1	670	6	711	0.0e+00	661	COG0643	Chemotaxis protein histidine kinase CheA	716
646448878	165	46.31	13	161	14	162	7.0e-37	146	COG0835	Chemotaxis signal transduction protein	165
646448879	568	39.74	154	518	20	408	3.0e-55	209	COG0840	Methyl-accepting chemotaxis protein	408
646448880	290	50.73	27	289	1	268	2.0e-79	289	COG1352	Methylase of chemotaxis methyl-accepting proteins	268
646448881	350	57.97	3	344	1	345	7.0e-119	420	COG2201	Chemotaxis response regulator CheB, contains REC and protein-glutamate methylesterase domains	350
646448883	214	68.2	1	214	1	217	4.0e-76	277	COG3143	Chemotaxis regulator CheZ, phosphatase of CheY~P	217
646448884	383	49.31	1	363	1	363	2.0e-128	452	COG1377	Flagellar biosynthesis protein FlhB	363
646448885	697	60.09	2	695	1	696	0.0e+00	928	COG1298	Flagellar biosynthesis pathway, component FlhA	696
646448887	145	42.76	1	145	2	146	4.0e-25	107	COG3418	Flagellar biosynthesis/type III secretory pathway chaperone	146
646448888	99	42.11	1	95	1	93	1.0e-10	58.4	COG2747	Negative regulator of flagellin synthesis (anti-sigma28 factor)	93
646448889	222	36.62	10	221	8	219	1.0e-41	163	COG1261	Flagella basal body P-ring formation protein FlgA	220
646448890	139	48.18	2	137	1	133	2.0e-33	134	COG1815	Flagellar basal body rod protein FlgB	133
646448891	134	71.53	1	134	1	137	2.0e-48	184	COG1558	Flagellar basal body rod protein FlgC	137
646448892	223	45.74	1	223	1	222	7.0e-42	164	COG1843	Flagellar hook assembly protein FlgD	222
646448893	399	47.38	1	399	3	422	8.0e-86	311	COG1749	Flagellar hook protein FlgE	423
646448894	251	65.74	1	251	1	251	2.0e-91	328	COG4787	Flagellar basal body rod protein FlgF	251
646448895	260	56.44	1	260	1	263	1.0e-84	306	COG4786	Flagellar basal body rod protein FlgG	265
646448896	239	52.19	14	236	3	230	7.0e-66	243	COG2063	Flagellar basal body L-ring protein FlgH	230
646448897	369	61.88	8	369	7	365	1.0e-125	443	COG1706	Flagellar basal body P-ring protein FlgI	365
646448898	317	43.21	156	317	46	201	1.0e-43	170	COG1705	Flagellum-specific peptidoglycan hydrolase FlgJ	201
646448899	638	33.62	1	468	3	470	3.0e-69	256	COG1256	Flagellar hook-associated protein FlgK	552
646448900	309	18.94	1	309	1	358	1.0e-19	90.5	COG1344	Flagellin and related hook-associated protein FlgL	360
646448901	260	47.01	9	259	8	258	1.0e-47	183	COG1684	Flagellar biosynthesis protein FliR	258
646448902	89	52.81	1	89	1	89	5.0e-19	86	COG1987	Flagellar biosynthesis protein FliQ	89
646448903	258	57.38	14	257	5	248	1.0e-78	286	COG1338	Flagellar biosynthetic protein FliP	248
646448904	138	37.14	1	138	2	135	7.0e-22	96.5	COG3190	Flagellar biogenesis protein FliO	137
646448906	338	48.96	1	335	1	331	5.0e-100	358	COG1868	Flagellar motor switch protein FliM	332
646448907	162	37.82	8	162	9	159	7.0e-35	140	COG1580	Flagellar basal body-associated protein FliL	159
646448908	444	24.49	5	444	3	417	2.0e-19	90.5	COG3144	Flagellar hook-length control protein FliK	417
646448909	146	43.45	1	145	1	145	7.0e-19	86.5	COG2882	Flagellar biosynthesis chaperone FliJ	148
646448910	456	59.56	4	453	1	440	0.0e+00	627	COG1157	Flagellar biosynthesis/type III secretory pathway ATPase	441
646448911	253	29.22	13	253	12	229	5.0e-39	154	COG1317	Flagellar biosynthesis/type III secretory pathway protein FliH	234
646448912	330	51.36	1	330	9	339	6.0e-89	321	COG1536	Flagellar motor switch protein FliG	339
646448913	574	43.03	12	573	9	545	0.0e+00	475	COG1766	Flagellar biosynthesis/type III secretory pathway M-ring protein FliF/YscJ	545
646448914	104	45.28	1	104	2	105	1.0e-12	64.6	COG1677	Flagellar hook-basal body complex protein FliE	105
646448916	138	48.03	3	129	1	122	2.0e-32	131	COG1516	Flagellin-specific chaperone FliS	132
646448917	484	36.46	25	484	12	483	2.0e-44	173	COG1345	Flagellar capping protein FliD	483
646448918	280	38.38	3	268	2	272	9.0e-25	107	COG1344	Flagellin and related hook-associated protein FlgL	360
646448919	1150	29.85	664	1114	148	594	1.0e-66	248	COG3914	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family	620
646448920	375	37.47	1	373	1	374	5.0e-95	341	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
646448922	377	25.54	8	377	1	342	4.0e-35	142	COG0673	Predicted dehydrogenase	342
646448925	240	46.41	5	239	17	247	2.0e-61	229	COG1191	DNA-directed RNA polymerase specialized sigma subunit	247
646448928	262	44.4	4	262	81	329	5.0e-75	274	COG1702	Phosphate starvation-inducible protein PhoH, predicted ATPase	348
646448929	534	32.59	135	511	8	408	2.0e-36	147	COG0840	Methyl-accepting chemotaxis protein	408
646448931	212	28.12	1	160	1	151	7.0e-33	133	COG0698	Ribose 5-phosphate isomerase RpiB	151
646448932	172	35.44	13	168	1	147	3.0e-38	151	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
646448933	576	37.58	1	570	25	646	0.0e+00	499	COG1067	Predicted ATP-dependent protease	647
646448934	157	72.48	1	149	1	149	7.0e-54	202	COG3120	Macrodomain Ter protein organizer, MatP/YcbG family	149
646448937	554	37.37	143	513	13	408	1.0e-46	181	COG0840	Methyl-accepting chemotaxis protein	408
646448938	493	27.29	36	482	2	429	2.0e-44	173	COG3182	Uncharacterized iron-regulated membrane protein	442
646448940	522	59.72	16	522	25	530	0.0e+00	743	COG3131	Periplasmic glucans biosynthesis protein	534
646448941	849	65.21	64	840	1	735	0.0e+00	1008	COG2943	Membrane glycosyltransferase	736
646448942	408	24.61	18	398	20	389	8.0e-23	101	COG2814	Predicted arabinose efflux permease, MFS family	394
646448943	306	52.94	4	306	3	307	1.0e-93	336	COG1560	Lauroyl/myristoyl acyltransferase	308
646448944	364	44.44	1	337	3	332	4.0e-99	354	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646448945	352	41.25	20	339	1	308	2.0e-97	349	COG1054	Predicted sulfurtransferase	308
646448946	193	46.91	3	193	1	192	2.0e-48	185	COG2353	Polyisoprenoid-binding periplasmic protein YceI	192
646448947	184	46.93	3	181	1	179	3.0e-45	174	COG3038	Cytochrome b561	181
646448950	349	65.4	8	348	5	343	0.0e+00	549	COG0418	Dihydroorotase	344
646448951	95	34.38	1	95	2	97	1.0e-16	77.7	COG1359	Quinol monooxygenase YgiN	100
646448952	1075	56.07	1	493	1	487	0.0e+00	571	COG1530	Ribonuclease G or E	487
646448953	320	44.82	8	303	1	288	5.0e-76	278	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646448954	200	43.52	7	198	2	192	1.0e-57	216	COG0424	Predicted house-cleaning NTP pyrophosphatase, Maf/HAM1 superfamily	193
646448955	173	41.01	1	173	1	176	8.0e-34	136	COG1399	Uncharacterized metal-binding protein YceD, DUF177 family	176
646448956	56	49.12	1	56	1	57	2.0e-11	60.3	COG0333	Ribosomal protein L32	57
646448957	348	53.91	3	347	1	338	2.0e-122	432	COG0416	Fatty acid/phospholipid biosynthesis enzyme	338
646448958	316	57.32	1	316	2	322	8.0e-117	413	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
646448959	309	57.74	1	309	1	310	6.0e-107	380	COG0331	Malonyl CoA-acyl carrier protein transacylase	310
646448960	244	49.01	1	241	1	250	4.0e-49	188	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646448961	78	64.1	1	78	3	80	4.0e-12	63	COG0236	Acyl carrier protein	80
646448962	412	57.49	2	412	1	411	0.0e+00	486	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646448963	267	27.31	1	261	3	272	5.0e-43	168	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
646448964	344	46.99	1	330	6	337	8.0e-112	397	COG1559	Cell division protein YceG, involved in septum cleavage	342
646448965	214	50.48	1	206	1	205	2.0e-57	215	COG0125	Thymidylate kinase	208
646448967	264	53.08	1	256	1	256	7.0e-83	300	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
646448968	477	39.23	1	397	1	393	7.0e-73	268	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
646448969	353	39.32	1	347	4	346	4.0e-73	268	COG2055	Malate/lactate/ureidoglycolate dehydrogenase, LDH2 family	349
646448970	116	37.93	3	116	1	113	5.0e-25	106	COG0537	Diadenosine tetraphosphate (Ap4A) hydrolase or other HIT family hydrolase	138
646448971	132	39.09	23	132	14	123	4.0e-22	97	COG5633	Uncharacterized conserved protein YcfL	123
646448972	197	41.09	1	197	4	200	7.0e-39	153	COG3417	Outer membrane lipoprotein LpoB, binds and activates PBP1b	200
646448973	284	19.55	22	282	5	262	1.0e-22	100	COG0510	Thiamine kinase and related kinases	269
646448974	341	44.67	1	295	5	296	1.0e-76	280	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
646448975	180	50.26	1	180	1	189	2.0e-63	235	COG3150	Predicted esterase YcpF, UPF0227 family	191
646448976	435	42.14	7	424	4	405	6.0e-120	424	COG1252	NADH dehydrogenase, FAD-containing subunit	405
646448977	179	83.24	1	179	1	179	2.0e-70	258	COG3134	Uncharacterized conserved protein YcfJ, contains glycine zipper 2TM domain	179
646448978	357	27.89	7	341	3	333	8.0e-51	194	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646448979	432	22.78	7	432	13	442	3.0e-28	119	COG2271	Sugar phosphate permease	448
646448980	791	32.99	24	787	27	772	0.0e+00	625	COG1501	Alpha-glucosidase, glycosyl hydrolase family GH31	772
646448981	271	37.4	10	256	9	260	2.0e-43	169	COG2162	Arylamine N-acetyltransferase	275
646448982	449	20.77	1	449	6	418	1.0e-59	224	COG0443	Molecular chaperone DnaK (HSP70)	579
646448983	501	38.55	253	501	8	252	3.0e-65	243	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
646448984	1150	55.71	12	1147	6	1137	0.0e+00	1527	COG1197	Transcription-repair coupling factor (superfamily II helicase)	1139
646448985	401	42.58	1	401	1	408	1.0e-103	369	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
646448986	235	49.33	6	227	1	223	1.0e-76	279	COG1136	ABC-type lipoprotein export system, ATPase component	226
646448987	415	41.59	3	415	2	408	7.0e-108	384	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
646448988	308	39.23	1	301	7	306	1.0e-56	213	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646448989	276	45.12	27	264	1	242	9.0e-71	260	COG0846	NAD-dependent protein deacetylase, SIR2 family	250
646448991	346	68.24	26	343	6	323	3.0e-99	355	COG4139	ABC-type cobalamin transport system, permease component	326
646448992	183	48.63	1	183	1	162	1.0e-62	232	COG0386	Glutathione peroxidase, house-cleaning role in reducing lipid peroxides	162
646448993	256	49.8	6	252	3	245	5.0e-74	271	COG4138	ABC-type cobalamin transport system, ATPase component	248
646448995	338	40	1	248	2	248	2.0e-56	212	COG0095	Lipoate-protein ligase A	248
646448996	244	24.48	12	239	18	251	5.0e-14	71.9	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
646448997	483	47.41	4	483	7	488	0.0e+00	606	COG0397	Uncharacterized conserved protein YdiU, UPF0061 family	488
646448998	567	44.48	1	567	1	561	0.0e+00	526	COG2989	Murein L,D-transpeptidase YcbB/YkuD	561
646448999	182	52.75	1	182	1	182	1.0e-64	239	COG3108	Uncharacterized conserved protein YcbK, DUF882 family	185
646449000	212	36.11	1	209	12	227	1.0e-34	139	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646449001	396	63.13	1	396	1	396	0.0e+00	621	COG1448	Aspartate/tyrosine/aromatic aminotransferase	396
646449002	359	41.1	4	359	3	354	1.0e-47	184	COG3203	Outer membrane protein (porin)	354
646449003	361	48.09	2	361	1	354	5.0e-59	221	COG3203	Outer membrane protein (porin)	354
646449004	361	48.78	2	361	1	354	9.0e-59	221	COG3203	Outer membrane protein (porin)	354
646449005	466	46.91	1	466	2	435	0.0e+00	549	COG0017	Aspartyl/asparaginyl-tRNA synthetase	435
646449006	401	37.75	1	399	3	381	3.0e-95	342	COG1488	Nicotinic acid phosphoribosyltransferase	405
646449007	871	42.33	1	864	5	859	0.0e+00	741	COG0308	Aminopeptidase N	859
646449008	262	47.98	14	253	1	248	1.0e-75	276	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
646449009	263	50.2	3	255	4	256	2.0e-61	229	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	258
646449010	382	40.62	8	353	1	332	3.0e-57	215	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
646449011	319	32.11	1	318	1	326	5.0e-45	175	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	335
646449012	184	36.26	1	175	1	182	6.0e-28	117	COG0431	NAD(P)H-dependent FMN reductase	184
646449013	335	44.63	45	335	3	288	3.0e-92	332	COG0167	Dihydroorotate dehydrogenase	310
646449015	367	55.97	1	267	1	266	7.0e-89	321	COG3217	Uncharacterized conserved protein YcbX, contains MOSC and Fe-S domains	270
646449016	707	51.04	1	383	2	380	0.0e+00	472	COG0116	23S rRNA G2445 N2-methylase RlmL	381
646449017	644	44.61	1	531	1	528	0.0e+00	538	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646449018	422	48.51	10	410	17	409	2.0e-125	442	COG2995	Uncharacterized paraquat-inducible protein A	418
646449019	548	43.45	1	547	4	552	0.0e+00	611	COG3008	Paraquat-inducible protein B	553
646449020	188	43.39	1	184	1	186	4.0e-33	134	COG3009	Uncharacterized lipoprotein YmbA	190
646449021	55	78.18	1	55	1	55	1.0e-16	77.8	COG3130	Ribosome modulation factor	55
646449022	350	62	1	349	2	351	0.0e+00	537	COG0722	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	351
646449023	273	51.07	1	273	2	273	1.0e-88	319	COG1806	Regulator of PEP synthase PpsR, kinase-PPPase family (combines ADP:protein kinase and phosphorylase activities)	273
646449024	792	49.74	8	790	2	736	0.0e+00	774	COG0574	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase	740
646449025	366	24.71	1	346	2	340	3.0e-31	129	COG0628	Predicted PurR-regulated permease PerM	355
646449026	1019	32.56	31	543	11	459	3.0e-79	290	COG0277	FAD/FMN-containing dehydrogenase	459
646449027	140	31.39	1	136	1	137	1.0e-27	115	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
646449029	334	38.18	22	238	21	232	2.0e-34	139	COG1376	Lipoprotein-anchoring transpeptidase ErfK/SrfK	232
646449030	78	69.23	1	78	1	78	5.0e-16	75.9	COG4238	Outer membrane murein-binding lipoprotein Lpp	78
646449031	470	55.37	1	470	4	477	0.0e+00	584	COG0469	Pyruvate kinase	477
646449033	649	29.92	95	453	3	373	3.0e-66	247	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
646449033	649	47.33	500	648	5	154	5.0e-48	186	COG2190	Phosphotransferase system IIA component	156
646449034	465	47.64	3	462	2	456	0.0e+00	566	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
646449035	394	29.15	80	394	2	297	4.0e-58	219	COG2382	Enterochelin esterase or related enzyme	299
646449036	354	25.48	43	343	6	306	6.0e-33	135	COG1619	Muramoyltetrapeptide carboxypeptidase LdcA (peptidoglycan recycling)	313
646449040	457	34.36	2	455	10	455	1.0e-74	274	COG0534	Na+-driven multidrug efflux pump	455
646449041	218	49.04	1	208	1	201	1.0e-72	266	COG0307	Riboflavin synthase alpha chain	204
646449042	383	50.35	97	371	1	282	3.0e-96	345	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	283
646449043	341	45.97	2	335	1	333	5.0e-97	348	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646449044	334	31.12	132	325	5	197	2.0e-30	127	COG0791	Cell wall-associated hydrolase, NlpC family	197
646449045	116	65.71	2	105	1	105	2.0e-45	173	COG0278	Glutaredoxin-related protein	105
646449046	226	34.91	8	212	1	231	2.0e-27	115	COG0847	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease	243
646449047	135	26.09	1	125	1	138	1.0e-13	68.7	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646449048	79	51.35	5	78	1	74	2.0e-17	80.8	COG3313	Predicted Fe-S protein YdhL, DUF1289 family	74
646449049	145	29.2	14	126	5	116	2.0e-10	58.4	COG1846	DNA-binding transcriptional regulator, MarR family	126
646449050	155	68.67	5	154	6	154	3.0e-37	147	COG3133	Outer membrane lipoprotein SlyB	154
646449051	370	61.25	1	367	2	370	3.0e-128	452	COG2377	1,6-Anhydro-N-acetylmuramate kinase	371
646449052	102	37.14	4	102	8	111	3.0e-21	93.6	COG3895	Membrane-bound inhibitor of C-type lysozyme	112
646449053	232	58.77	23	232	4	214	3.0e-87	314	COG0259	Pyridoxine/pyridoxamine 5'-phosphate oxidase	214
646449054	424	50.71	1	423	1	401	0.0e+00	487	COG0162	Tyrosyl-tRNA synthetase	401
646449055	286	51.93	2	286	1	280	2.0e-97	349	COG2240	Pyridoxal/pyridoxine/pyridoxamine kinase	281
646449056	204	31.92	1	204	1	211	7.0e-28	117	COG0625	Glutathione S-transferase	211
646449057	890	63.91	7	888	2	860	0.0e+00	1225	COG1048	Aconitase A	861
646449058	539	35.83	1	538	2	562	7.0e-114	404	COG4166	ABC-type oligopeptide transport system, periplasmic component	562
646449059	197	67.53	1	194	1	193	2.0e-76	278	COG0807	GTP cyclohydrolase II	193
646449061	102	75.58	1	86	1	86	1.0e-29	121	COG3771	Uncharacterized membrane protein YciS, DUF1049 family	97
646449062	389	67.1	1	389	1	389	0.0e+00	554	COG2956	Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain	389
646449063	249	48.25	22	249	14	237	7.0e-69	254	COG0284	Orotidine-5'-phosphate decarboxylase	240
646449064	108	56.73	8	108	1	103	6.0e-24	102	COG0023	Translation initiation factor 1 (eIF-1/SUI1)	104
646449066	232	39.66	1	232	3	218	1.0e-58	219	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
646449068	688	43.77	32	685	1	575	0.0e+00	586	COG1966	Carbon starvation protein CstA	575
646449069	305	45.11	1	305	1	298	1.0e-101	363	COG4989	Predicted oxidoreductase	298
646449070	643	74.88	1	643	1	645	0.0e+00	1082	COG4776	Exoribonuclease II	645
646449071	169	29.03	14	168	1	136	5.0e-16	77.4	COG5346	Uncharacterized membrane protein	136
646449073	769	22.92	9	761	9	765	7.0e-104	372	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
646449075	300	30.77	1	296	1	291	1.0e-25	110	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449078	263	61.15	1	260	1	259	1.0e-110	392	COG0623	Enoyl-[acyl-carrier-protein] reductase (NADH)	259
646449079	271	78.28	2	268	1	267	4.0e-119	420	COG4167	ABC-type antimicrobial peptide transport system, ATPase component	267
646449080	330	82.98	1	329	1	329	0.0e+00	601	COG4170	ABC-type antimicrobial peptide transport system, ATPase component	330
646449081	296	73.31	1	296	1	296	9.0e-114	403	COG4171	ABC-type antimicrobial peptide transport system, permease component	296
646449082	321	73.21	1	321	1	321	2.0e-126	445	COG4168	ABC-type antimicrobial peptide transport system, permease component	321
646449083	579	26.22	9	551	1	561	5.0e-80	292	COG4166	ABC-type oligopeptide transport system, periplasmic component	562
646449084	396	35.29	4	375	1	323	3.0e-82	299	COG0523	GTPase, G3E family	323
646449085	332	47.58	1	328	73	398	2.0e-91	328	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain	403
646449086	221	43.3	1	221	1	224	8.0e-27	113	COG1842	Phage shock protein A	225
646449088	119	38.24	6	72	2	69	7.0e-15	72.5	COG1983	Phage shock protein PspC (stress-responsive transcriptional regulator)	70
646449089	471	67.46	9	471	4	467	0.0e+00	682	COG3106	Predicted ATPase, YcjX-like family	467
646449090	351	56.89	4	342	1	339	7.0e-107	380	COG3768	Uncharacterized membrane protein YcjF, UPF0283 family	350
646449092	520	18.87	39	509	12	403	5.0e-29	122	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646449093	521	66.67	1	515	1	511	0.0e+00	724	COG3283	Transcriptional regulator of aromatic amino acids metabolism	511
646449096	305	32.01	3	300	2	297	8.0e-38	150	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449097	465	28.77	16	425	1	414	8.0e-48	184	COG0402	Cytosine/adenosine deaminase or related metal-dependent hydrolase	421
646449098	157	38.89	1	144	2	143	3.0e-16	77.9	COG3238	Uncharacterized membrane protein YdcZ, DUF606 family	150
646449099	322	38.29	1	312	1	309	1.0e-76	280	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646449100	182	30.51	1	175	2	178	5.0e-22	97.7	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646449101	791	28.33	24	766	2	746	2.0e-75	277	COG2366	Acyl-homoserine lactone (AHL) acylase PvdQ	768
646449104	167	63.06	3	159	2	158	1.0e-64	238	COG2077	Peroxiredoxin	158
646449106	543	38.72	3	542	1	562	8.0e-123	434	COG4166	ABC-type oligopeptide transport system, periplasmic component	562
646449107	325	24.57	39	325	34	322	2.0e-56	212	COG0598	Mg2+ and Co2+ transporter CorA	322
646449108	313	34.43	17	283	1	266	2.0e-54	206	COG0037	tRNA(Ile)-lysidine synthase TilS/MesJ	298
646449109	641	38.75	480	639	46	189	6.0e-29	122	COG1705	Flagellum-specific peptidoglycan hydrolase FlgJ	201
646449111	674	38.13	260	609	34	408	4.0e-50	193	COG0840	Methyl-accepting chemotaxis protein	408
646449112	96	30	27	96	16	85	5.0e-07	45.8	COG3042	Putative hemolysin	85
646449113	330	47.18	1	330	1	323	2.0e-96	345	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
646449114	517	29.21	159	513	29	406	7.0e-44	172	COG0840	Methyl-accepting chemotaxis protein	408
646449117	390	22.7	8	377	13	364	3.0e-18	86.8	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
646449118	201	52.97	1	199	1	202	5.0e-70	257	COG1182	FMN-dependent NADH-azoreductase	202
646449119	1295	40.59	18	956	1	845	0.0e+00	829	COG1643	HrpA-like RNA helicase	845
646449120	232	44.16	2	232	1	218	6.0e-56	210	COG1556	L-lactate utilization protein LutC, contains LUD domain	218
646449121	473	59.14	4	464	1	459	0.0e+00	657	COG1139	L-lactate utilization protein LutB, contains a ferredoxin-type domain	459
646449123	516	35.06	3	514	2	519	1.0e-91	330	COG1620	L-lactate permease	522
646449124	272	26.94	1	269	1	251	4.0e-46	178	COG3591	V8-like Glu-specific endopeptidase	251
646449126	451	30.61	108	429	11	335	4.0e-39	156	COG0642	Signal transduction histidine kinase	336
646449127	247	40.08	2	241	1	229	5.0e-52	197	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646449129	657	38.68	106	647	12	546	3.0e-105	376	COG0659	Sulfate permease or related transporter, MFS superfamily	554
646449130	366	40.38	4	366	1	366	6.0e-70	258	COG0387	Ca2+/H+ antiporter	368
646449131	230	47.59	34	219	1	185	3.0e-49	188	COG3703	Cation transport regulator ChaC	190
646449132	346	42.15	22	346	9	314	6.0e-71	261	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646449133	286	50	11	282	12	285	8.0e-67	247	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646449134	280	40.51	8	276	1	274	2.0e-70	258	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
646449135	228	42.08	6	226	2	221	1.0e-61	229	COG1124	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	252
646449136	526	24.46	3	523	20	556	4.0e-51	195	COG0747	ABC-type transport system, periplasmic component	556
646449137	428	26.27	16	419	4	418	7.0e-39	155	COG0038	H+/Cl- antiporter ClcA	443
646449140	515	32.99	150	515	20	407	6.0e-50	192	COG0840	Methyl-accepting chemotaxis protein	408
646449142	562	33.58	138	517	4	408	1.0e-52	200	COG0840	Methyl-accepting chemotaxis protein	408
646449143	604	38.86	427	599	1	173	4.0e-35	143	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646449144	434	32.14	20	434	11	412	9.0e-83	300	COG0402	Cytosine/adenosine deaminase or related metal-dependent hydrolase	421
646449146	391	30.46	13	380	5	349	2.0e-56	213	COG3500	Phage protein D	350
646449147	165	48.95	2	144	1	141	3.0e-40	157	COG3499	Phage protein U	147
646449151	172	47.09	1	172	1	169	4.0e-43	167	COG3498	Phage tail tube protein FII	169
646449152	389	53.69	1	387	2	394	6.0e-125	440	COG3497	Phage tail sheath protein FI	394
646449155	193	41.83	1	190	2	209	2.0e-33	135	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
646449157	451	24.38	49	393	64	380	9.0e-16	78.5	COG4222	Uncharacterized conserved protein	391
646449158	448	20.24	23	442	13	394	8.0e-17	81.8	COG2814	Predicted arabinose efflux permease, MFS family	394
646449159	188	37.43	1	175	7	184	7.0e-35	140	COG2840	DNA-nicking endonuclease, Smr domain	184
646449161	203	50	1	201	1	204	6.0e-59	220	COG4385	Bacteriophage P2-related tail formation protein	206
646449162	302	61.26	1	302	5	306	2.0e-98	352	COG3948	Phage-related baseplate assembly protein	306
646449163	116	51.02	3	100	2	99	9.0e-30	121	COG3628	Phage baseplate assembly protein W	116
646449164	217	39.2	18	216	2	183	4.0e-41	161	COG4540	Phage P2 baseplate assembly protein gpV	184
646449166	67	52.94	1	67	3	70	2.0e-19	87.4	COG5004	P2-like prophage tail protein X	70
646449176	669	38.74	253	609	27	408	2.0e-52	200	COG0840	Methyl-accepting chemotaxis protein	408
646449178	482	37.24	27	312	71	354	6.0e-73	268	COG0144	16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family	355
646449179	876	46.33	1	568	1	553	0.0e+00	577	COG3008	Paraquat-inducible protein B	553
646449180	423	50.12	20	421	15	407	9.0e-122	430	COG2995	Uncharacterized paraquat-inducible protein A	418
646449181	171	61.78	1	157	7	163	2.0e-57	215	COG1956	GAF domain-containing protein, putative methionine-R-sulfoxide reductase	163
646449182	240	64.17	1	240	1	208	2.0e-63	235	COG3109	sRNA-binding protein	208
646449183	673	34.89	122	589	1	406	8.0e-96	345	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	406
646449185	426	23.36	1	350	9	319	3.0e-18	86.8	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
646449186	215	46.38	8	214	3	208	1.0e-52	199	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646449187	602	42.45	7	593	1	573	0.0e+00	503	COG3850	Signal transduction histidine kinase, nitrate/nitrite-specific	574
646449188	463	42.83	25	463	2	407	2.0e-93	336	COG2223	Nitrate/nitrite transporter NarK	417
646449189	335	24.26	74	267	11	203	4.0e-15	75.7	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646449190	296	32.67	3	296	2	295	1.0e-35	143	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449191	1256	77.35	1	1235	1	1227	0.0e+00	2151	COG5013	Nitrate reductase alpha subunit	1227
646449192	519	79.22	1	508	1	510	0.0e+00	943	COG1140	Nitrate reductase beta subunit	513
646449193	239	47.22	1	180	4	179	7.0e-39	153	COG2180	Nitrate reductase assembly protein NarJ, required for insertion of molybdenum cofactor	179
646449194	225	58.67	3	225	1	225	6.0e-69	253	COG2181	Nitrate reductase gamma subunit	228
646449195	382	50.79	5	382	4	377	6.0e-124	437	COG1454	Alcohol dehydrogenase, class IV	377
646449196	341	55.94	14	332	22	339	1.0e-106	380	COG3376	High-affinity nickel permease	342
646449197	152	37.93	10	123	6	119	2.0e-17	82	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646449198	78	43.33	1	60	1	56	5.0e-08	49.5	COG1942	Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family	69
646449199	160	57.14	1	160	2	162	1.0e-66	245	COG0386	Glutathione peroxidase, house-cleaning role in reducing lipid peroxides	162
646449201	204	28.64	8	202	3	196	4.0e-18	84.5	COG1183	Phosphatidylserine synthase	234
646449202	432	19.83	1	335	2	326	3.0e-14	73.7	COG0439	Biotin carboxylase	449
646449204	204	24.23	35	198	39	232	3.0e-19	88.8	COG2071	Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD (putrescine degradation), contains GATase1-like domain	243
646449205	241	25.21	1	231	4	221	6.0e-25	107	COG1213	Choline kinase	239
646449206	346	32.14	17	345	1	332	6.0e-56	211	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646449207	448	24.26	20	444	8	438	1.0e-26	114	COG2271	Sugar phosphate permease	448
646449209	358	41.49	42	354	32	350	1.0e-73	270	COG4225	Rhamnogalacturonyl hydrolase YesR	357
646449210	207	31.03	2	200	1	200	5.0e-30	124	COG0625	Glutathione S-transferase	211
646449211	343	31.71	1	339	1	330	4.0e-70	258	COG0620	Methionine synthase II (cobalamin-independent)	330
646449213	364	30.08	225	357	1	126	4.0e-16	79.5	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646449214	350	26.32	5	340	4	354	3.0e-45	175	COG4188	Predicted dienelactone hydrolase	365
646449215	76	34.62	1	52	1	52	2.0e-07	47.6	COG1942	Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family	69
646449216	364	44.51	1	360	2	352	1.0e-113	403	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
646449218	495	38.45	19	490	3	456	2.0e-110	393	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
646449219	421	51.63	1	420	16	444	0.0e+00	498	COG0160	4-aminobutyrate aminotransferase or related aminotransferase	447
646449220	486	48.11	11	484	1	471	0.0e+00	515	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646449221	343	25.83	5	340	16	363	2.0e-52	199	COG0687	Spermidine/putrescine-binding periplasmic protein	363
646449222	423	48.18	196	415	60	279	3.0e-63	236	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
646449223	278	44.14	21	276	12	267	4.0e-59	221	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
646449224	259	33.2	6	257	1	253	3.0e-52	198	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646449225	263	33.97	6	262	3	260	5.0e-57	214	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
646449226	392	21.41	32	383	21	401	4.0e-10	59.5	COG0738	Fucose permease	422
646449227	527	31.17	5	525	14	552	1.0e-91	330	COG0747	ABC-type transport system, periplasmic component	556
646449228	328	49.68	13	326	7	314	2.0e-82	299	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646449229	301	43.4	14	299	2	289	8.0e-67	247	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646449230	566	52.92	1	553	2	538	0.0e+00	644	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
646449231	259	31.54	3	253	1	249	3.0e-32	132	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646449232	400	47.81	11	396	10	392	2.0e-112	399	COG1473	Metal-dependent amidase/aminoacylase/carboxypeptidase	392
646449233	418	29.45	1	410	5	373	1.0e-41	164	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
646449235	304	31.49	5	290	4	288	9.0e-58	217	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646449236	311	32.41	22	305	1	276	4.0e-48	185	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
646449237	260	55.24	8	255	2	239	3.0e-95	341	COG1126	ABC-type polar amino acid transport system, ATPase component	240
646449238	224	43.98	5	220	6	221	1.0e-52	199	COG0765	ABC-type amino acid transport system, permease component	222
646449239	223	43.32	5	221	6	222	5.0e-50	191	COG0765	ABC-type amino acid transport system, permease component	222
646449240	384	55.01	3	379	7	392	0.0e+00	475	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
646449241	455	48.22	3	309	1	300	2.0e-99	356	COG0031	Cysteine synthase	300
646449242	469	26.26	9	455	5	440	2.0e-45	177	COG2079	2-methylcitrate dehydratase PrpD	453
646449243	276	27.17	4	258	1	264	1.0e-23	103	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646449244	651	38.68	254	608	29	408	4.0e-51	196	COG0840	Methyl-accepting chemotaxis protein	408
646449245	657	37.5	234	608	9	408	4.0e-51	196	COG0840	Methyl-accepting chemotaxis protein	408
646449246	409	68.09	1	398	1	397	0.0e+00	574	COG1133	ABC-type long-chain fatty acid transport system, fused permease and ATPase components	405
646449248	359	33.52	1	356	6	360	6.0e-66	244	COG1377	Flagellar biosynthesis protein FlhB	363
646449249	267	28.69	5	241	1	235	6.0e-25	107	COG4791	Type III secretory pathway, component EscT	259
646449250	86	49.35	9	85	12	88	6.0e-11	59.1	COG4794	Type III secretory pathway, component EscS	89
646449251	217	47.87	7	217	3	213	3.0e-54	205	COG4790	Type III secretory pathway, component EscR	214
646449255	460	51.14	18	454	9	438	0.0e+00	520	COG1157	Flagellar biosynthesis/type III secretory pathway ATPase	441
646449257	700	42.18	7	691	1	688	0.0e+00	632	COG4789	Type III secretory pathway, component EscV	689
646449259	184	28.07	13	183	7	176	6.0e-23	100	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646449261	213	38.28	5	212	1	209	8.0e-45	173	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646449265	268	40.68	8	242	4	232	3.0e-47	182	COG4669	Type III secretory pathway, lipoprotein EscJ	246
646449268	440	47.35	69	368	41	340	2.0e-80	293	COG2951	Membrane-bound lytic murein transglycosylase B	343
646449275	690	26.41	32	544	26	555	4.0e-61	229	COG1450	Type II secretory pathway component GspD/PulD (secretin)	587
646449279	558	33.27	20	558	18	554	1.0e-99	357	COG2831	Hemolysin activation/secretion protein	554
646449287	101	27.96	5	97	4	95	2.0e-08	50.4	COG3668	Plasmid stabilization system protein ParE	98
646449289	75	43.84	1	73	1	72	1.0e-11	61.4	COG1918	Fe2+ transport system protein FeoA	75
646449290	774	41.42	4	736	3	653	0.0e+00	651	COG0370	Fe2+ transport system protein B	653
646449292	423	46.75	1	408	3	414	2.0e-129	456	COG2195	Di- or tripeptidase	414
646449293	373	58.93	1	373	9	383	0.0e+00	463	COG2850	Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain	383
646449294	487	25.23	160	477	7	327	6.0e-35	142	COG0642	Signal transduction histidine kinase	336
646449295	222	40.97	1	221	1	226	1.0e-52	199	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646449296	455	34.65	12	455	1	435	3.0e-118	419	COG0015	Adenylosuccinate lyase	438
646449297	212	65.05	2	207	1	206	6.0e-72	263	COG2915	Regulator of phage lambda lysogenization HflD, binds to CII and stimulates its degradation	207
646449298	370	61.81	4	365	1	355	0.0e+00	511	COG0482	tRNA U34 2-thiouridine synthase MnmA/TrmU, contains the PP-loop ATPase domain	356
646449299	152	27.83	4	116	9	123	3.0e-09	54.7	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
646449300	218	38.86	32	216	55	234	5.0e-48	184	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
646449301	417	67.56	10	417	2	406	0.0e+00	619	COG0538	Isocitrate dehydrogenase	407
646449304	294	31.63	2	289	22	295	2.0e-44	173	COG0501	Zn-dependent protease with chaperone function	302
646449306	152	44.27	3	131	1	131	2.0e-33	135	COG1943	REP element-mobilizing transposase RayT	136
646449307	388	15.9	1	387	58	425	1.0e-35	144	COG0823	Periplasmic component of the Tol biopolymer transport system	425
646449308	263	43.09	14	258	1	246	6.0e-69	254	COG1414	DNA-binding transcriptional regulator, IclR family	246
646449310	642	54.35	34	641	1	589	0.0e+00	804	COG0441	Threonyl-tRNA synthetase	589
646449311	180	66.67	4	180	1	176	1.0e-64	238	COG0290	Translation initiation factor IF-3	176
646449312	65	67.69	1	65	1	65	3.0e-11	60.2	COG0291	Ribosomal protein L35	65
646449313	118	82.2	1	118	1	118	2.0e-40	157	COG0292	Ribosomal protein L20	118
646449314	327	59.16	1	325	3	335	0.0e+00	465	COG0016	Phenylalanyl-tRNA synthetase alpha subunit	335
646449315	795	49.47	143	794	1	650	0.0e+00	729	COG0072	Phenylalanyl-tRNA synthetase beta subunit	650
646449316	99	50.54	2	94	1	93	2.0e-28	116	COG0776	Bacterial nucleoid DNA-binding protein	94
646449319	274	44.78	16	274	2	262	8.0e-76	277	COG0171	NH3-dependent NAD+ synthetase	268
646449321	463	74.84	1	457	2	457	0.0e+00	596	COG1823	L-cystine uptake protein TcyP, sodium:dicarboxylate symporter family	458
646449322	192	31.58	1	182	1	180	2.0e-20	92.4	COG1988	Membrane-bound metal-dependent hydrolase YbcI, DUF457 family	190
646449323	310	21.4	16	275	25	290	1.0e-20	94.2	COG0657	Acetyl esterase/lipase	312
646449325	430	26.56	1	426	5	432	4.0e-45	175	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
646449326	375	46.2	1	368	1	338	8.0e-117	413	COG3839	ABC-type sugar transport system, ATPase component	338
646449327	300	36.04	19	299	1	281	3.0e-62	231	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
646449328	296	43.86	4	284	8	290	4.0e-54	205	COG1175	ABC-type sugar transport system, permease component	295
646449330	253	37.25	6	251	1	251	6.0e-47	181	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646449331	278	71.22	1	278	1	278	0.0e+00	464	COG3717	5-keto 4-deoxyuronate isomerase	278
646449334	285	61.97	1	284	1	284	1.0e-111	396	COG3001	Fructosamine-3-kinase	286
646449335	69	70.15	3	69	1	67	2.0e-24	104	COG1278	Cold shock protein, CspA family	67
646449337	190	52.66	1	186	1	188	9.0e-46	176	COG1971	Putative Mn2+ efflux pump MntP	190
646449338	152	57.24	1	152	1	152	1.0e-41	161	COG4811	Uncharacterized membrane protein YobD, UPF0266 family	152
646449339	278	58.67	6	276	5	269	1.0e-108	386	COG3716	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID	269
646449340	265	55.85	2	265	1	264	6.0e-68	250	COG3715	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC	265
646449341	318	66.04	157	315	1	159	2.0e-59	222	COG3444	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB	159
646449342	516	52.23	1	243	8	254	4.0e-70	259	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
646449343	453	53.41	171	449	3	262	3.0e-91	329	COG1760	L-serine deaminase	262
646449344	207	17.88	34	175	1	147	4.0e-08	51.5	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
646449345	456	41.15	27	454	24	458	0.0e+00	472	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
646449346	61	76.27	1	58	1	59	9.0e-12	62	COG3140	Uncharacterized conserved protein YoaH, UPF0181 family	60
646449347	115	34.71	1	114	8	128	2.0e-24	104	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
646449348	639	43.56	10	638	1	650	0.0e+00	537	COG1199	Rad3-related DNA helicase	654
646449349	233	43.86	4	228	2	219	2.0e-54	205	COG1214	tRNA A37 threonylcarbamoyladenosine modification protein TsaB	220
646449350	209	47.34	22	208	7	191	7.0e-54	203	COG3065	Starvation-inducible outer membrane lipoprotein	191
646449351	567	40.83	24	563	1	524	0.0e+00	463	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646449352	373	50.82	6	370	1	359	9.0e-108	383	COG0349	Ribonuclease D	361
646449353	96	60.47	1	86	1	85	5.0e-26	109	COG0851	Septum formation topological specificity factor MinE	88
646449354	270	75.56	1	270	1	269	1.0e-125	442	COG2894	Septum formation inhibitor-activating ATPase MinD	272
646449355	232	47.14	6	231	1	217	3.0e-61	228	COG0850	Septum formation inhibitor MinC	219
646449356	90	63.33	1	90	11	100	2.0e-28	117	COG3100	Uncharacterized conserved protein YcgL, UPF0745 family	103
646449357	218	44.75	1	209	37	253	5.0e-64	237	COG0179	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	266
646449358	148	60.14	1	148	6	153	8.0e-58	215	COG2983	Uncharacterized cysteine cluster protein YcgN, CxxCxxCC family	153
646449359	176	44.19	1	168	1	170	1.0e-29	122	COG1495	Disulfide bond formation protein DsbB	170
646449360	239	28.51	1	233	1	241	8.0e-38	150	COG2186	DNA-binding transcriptional regulator, FadR family	241
646449361	511	72.98	13	508	2	491	0.0e+00	742	COG2719	Stage V sporulation protein SpoVR/YcgB, involved in spore cortex formation (function unknown)	495
646449362	416	32.24	1	416	5	382	8.0e-51	194	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
646449363	373	24.9	66	308	1	250	2.0e-18	87.5	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
646449366	224	28.93	1	183	2	193	3.0e-17	82.2	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646449372	1169	38.85	14	1165	6	1078	0.0e+00	830	COG1330	Exonuclease V gamma subunit	1078
646449373	1230	32.59	4	1195	2	1139	0.0e+00	687	COG1074	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)	1139
646449374	681	28.86	6	681	41	690	8.0e-91	328	COG0507	ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I	696
646449375	188	24.74	1	179	3	185	8.0e-17	80.4	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646449376	457	37.37	1	422	28	513	5.0e-114	404	COG0513	Superfamily II DNA and RNA helicase	513
646449377	413	36.32	16	411	17	427	2.0e-81	296	COG5520	O-Glycosyl hydrolase	433
646449378	214	21.47	9	198	3	189	8.0e-10	57.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646449380	363	61.56	1	363	1	372	0.0e+00	522	COG0012	Ribosome-binding ATPase YchF, GTP1/OBG family	372
646449381	195	56.02	3	193	1	190	8.0e-75	273	COG0193	Peptidyl-tRNA hydrolase	190
646449383	315	60.44	1	314	2	314	5.0e-123	434	COG0462	Phosphoribosylpyrophosphate synthetase	314
646449384	290	47.74	7	280	5	287	2.0e-89	322	COG1947	4-diphosphocytidyl-2C-methyl-D-erythritol kinase	289
646449385	206	49.28	1	206	1	206	3.0e-52	198	COG3017	Outer membrane lipoprotein LolB, involved in outer membrane biogenesis	206
646449386	418	50.72	1	418	1	412	0.0e+00	477	COG0373	Glutamyl-tRNA reductase	414
646449387	361	67.49	1	359	1	363	0.0e+00	564	COG0216	Protein chain release factor A	363
646449388	282	46.26	1	279	1	280	6.0e-79	287	COG2890	Methylase of polypeptide chain release factors	280
646449390	269	52.42	1	269	2	269	6.0e-82	297	COG2912	Regulator of sirC expression, contains transglutaminase-like and TPR domains	269
646449391	284	65.84	2	282	1	279	0.0e+00	473	COG2877	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase	279
646449393	509	61.81	2	365	1	356	0.0e+00	463	COG3288	NAD/NADP transhydrogenase alpha subunit	356
646449394	457	58.9	2	457	7	463	0.0e+00	629	COG1282	NAD/NADP transhydrogenase beta subunit	463
646449395	323	24.05	155	303	7	154	5.0e-12	65.4	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
646449396	250	36.06	31	237	7	214	1.0e-39	156	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
646449397	179	43.71	3	167	1	167	4.0e-46	177	COG0350	O6-methylguanine-DNA--protein-cysteine methyltransferase	168
646449399	174	52.84	1	174	6	179	6.0e-44	170	COG2032	Cu/Zn superoxide dismutase	179
646449401	659	38.13	256	605	34	408	3.0e-55	210	COG0840	Methyl-accepting chemotaxis protein	408
646449402	168	58.86	8	164	6	163	1.0e-62	232	COG3479	Phenolic acid decarboxylase	175
646449403	297	27.34	6	277	2	276	3.0e-23	102	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449404	374	24.68	76	368	1	306	2.0e-36	146	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646449405	359	44.54	1	356	3	352	2.0e-100	359	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
646449406	284	24.19	6	281	15	284	6.0e-27	114	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
646449407	277	30.45	7	272	6	266	4.0e-37	148	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
646449408	375	28.92	11	324	3	323	8.0e-45	174	COG4134	ABC-type uncharacterized transport system YnjBCD, periplasmic component	384
646449409	252	33.86	12	251	1	250	2.0e-33	136	COG0584	Glycerophosphoryl diester phosphodiesterase	257
646449410	254	37.72	4	224	1	228	1.0e-45	176	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
646449412	612	20.26	13	603	7	536	2.0e-41	163	COG2303	Choline dehydrogenase or related flavoprotein	542
646449414	836	40.45	9	833	1	818	0.0e+00	741	COG4458	Uncharacterized protein	821
646449415	996	58.45	1	996	1	1014	0.0e+00	1368	COG4457	Uncharacterized protein	1014
646449417	285	38.04	1	268	2	274	3.0e-29	122	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
646449420	577	55.83	10	573	13	577	0.0e+00	673	COG4618	ABC-type protease/lipase transport system, ATPase and permease components	580
646449421	448	17.85	16	368	1	277	2.0e-07	51.1	COG1566	Multidrug resistance efflux pump	352
646449422	462	23.87	24	440	45	455	1.0e-36	147	COG1538	Outer membrane protein TolC	457
646449426	622	46.95	2	622	7	627	0.0e+00	678	COG3158	K+ transporter	627
646449427	230	57.6	15	230	17	231	6.0e-75	273	COG4305	Peptidoglycan-binding domain, expansin	232
646449428	322	31.43	1	310	2	316	1.0e-40	160	COG1275	Tellurite resistance protein TehA and related permeases	329
646449429	334	24.48	1	334	5	331	2.0e-33	136	COG3274	Surface polysaccharide O-acyltransferase, integral membrane enzyme	332
646449430	114	31.03	1	114	1	104	3.0e-16	77.2	COG2315	Predicted DNA-binding protein with ?double-wing? structural motif, MmcQ/YjbR family	118
646449432	186	28.89	1	177	7	176	1.0e-16	79.7	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646449433	303	23.81	7	296	1	288	3.0e-23	102	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449434	329	22.55	87	321	21	235	4.0e-12	65.6	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646449435	135	33.67	30	127	35	131	3.0e-17	80.6	COG1917	Cupin domain protein related to quercetin dioxygenase	131
646449436	217	30.1	114	214	22	123	7.0e-09	54.2	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	124
646449438	277	40	9	270	9	273	9.0e-49	187	COG3769	Predicted mannosyl-3-phosphoglycerate phosphatase, HAD superfamily	274
646449441	249	55.42	2	240	8	246	1.0e-86	312	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
646449444	223	50.45	1	219	1	221	6.0e-62	230	COG0132	Dethiobiotin synthetase	223
646449445	405	29.97	80	405	1	314	2.0e-50	193	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646449446	304	36.15	3	295	1	288	7.0e-39	154	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449447	419	24.01	39	412	10	383	6.0e-24	105	COG2814	Predicted arabinose efflux permease, MFS family	394
646449449	465	69.48	2	463	1	462	0.0e+00	784	COG0114	Fumarate hydratase class II	462
646449450	394	36.76	1	389	3	310	9.0e-88	317	COG1482	Mannose-6-phosphate isomerase, class I	312
646449451	517	30.89	4	490	1	474	4.0e-74	272	COG5339	Uncharacterized conserved protein YdgA, DUF945 family	479
646449452	337	37.69	1	334	6	339	2.0e-86	312	COG1816	Adenosine deaminase	345
646449453	152	52.03	7	151	7	154	2.0e-45	174	COG4875	Uncharacterized protein	156
646449454	331	39.09	1	330	1	317	7.0e-68	251	COG0385	Predicted Na+-dependent transporter	319
646449455	349	30.99	4	347	3	341	3.0e-51	195	COG0673	Predicted dehydrogenase	342
646449456	317	29.27	165	287	2	124	8.0e-23	101	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646449457	328	40.13	16	326	2	314	2.0e-59	223	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646449458	507	51.61	1	496	2	498	0.0e+00	639	COG1129	ABC-type sugar transport system, ATPase component	500
646449459	327	24.31	5	325	13	320	9.0e-32	131	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646449460	561	41.76	5	558	3	534	0.0e+00	593	COG1069	Ribulose kinase	544
646449461	503	67.47	1	498	1	495	0.0e+00	750	COG2160	L-arabinose isomerase	497
646449464	193	79.79	1	193	1	193	3.0e-68	251	COG4657	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfA subunit	193
646449465	196	63.35	1	190	1	191	1.0e-66	245	COG2878	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit	198
646449466	759	61.7	11	536	1	529	0.0e+00	668	COG4656	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfC subunit	529
646449467	350	59.89	2	350	1	336	2.0e-111	395	COG4658	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfD subunit	338
646449468	209	64.29	3	198	1	195	1.0e-75	276	COG4659	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfG subunit	195
646449469	231	77.83	1	212	1	212	5.0e-86	310	COG4660	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfE subunit	212
646449470	211	54.76	1	210	1	210	3.0e-84	304	COG0177	Endonuclease III	211
646449471	324	27	1	298	1	294	6.0e-38	151	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449472	873	47.61	3	601	1	569	0.0e+00	676	COG0550	DNA topoisomerase IA	570
646449476	348	31.82	45	341	5	310	7.0e-60	224	COG0616	Periplasmic serine protease, ClpP class	317
646449477	253	29.71	10	235	3	237	2.0e-39	156	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646449478	196	58.08	1	196	1	198	1.0e-76	279	COG2109	ATP:corrinoid adenosyltransferase	198
646449479	296	47.81	1	246	1	247	8.0e-72	264	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
646449480	206	44.88	2	205	1	204	2.0e-61	228	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
646449481	290	50	13	268	3	254	3.0e-65	241	COG0613	Predicted metal-dependent phosphoesterase TrpH, contains PHP domain	258
646449483	520	42.58	10	518	2	462	0.0e+00	463	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
646449484	192	49.48	1	190	1	191	5.0e-66	243	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
646449485	332	52.11	1	330	4	334	1.0e-111	396	COG0547	Anthranilate phosphoribosyltransferase	338
646449486	463	52.96	8	256	1	253	2.0e-89	322	COG0134	Indole-3-glycerol phosphate synthase	254
646449487	396	68.69	1	396	2	396	0.0e+00	693	COG0133	Tryptophan synthase beta chain	396
646449488	269	47.19	1	267	1	264	6.0e-88	317	COG0159	Tryptophan synthase alpha chain	265
646449490	210	60.83	1	210	1	213	4.0e-64	237	COG3047	Outer membrane protein W	213
646449492	123	31.25	9	118	11	119	3.0e-12	64.3	COG0727	Fe-S-cluster containining protein	132
646449494	186	62.22	1	180	1	180	9.0e-58	216	COG2917	Intracellular septation protein A	180
646449495	140	58.02	1	131	3	130	1.0e-47	181	COG1607	Acyl-CoA hydrolase	157
646449496	248	33.33	10	231	1	228	2.0e-12	66.7	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
646449497	98	59.18	1	98	1	92	3.0e-27	113	COG2350	Uncharacterized conserved protein YciI, contains a putative active-site phosphohistidine	92
646449498	567	29.17	175	533	27	408	9.0e-34	138	COG0840	Methyl-accepting chemotaxis protein	408
646449500	486	36.28	47	486	1	438	2.0e-87	316	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
646449501	107	76.64	1	107	2	108	4.0e-40	156	COG3099	Uncharacterized conserved protein YciU, UPF0263 family	108
646449503	329	58.04	11	323	1	314	2.0e-129	455	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
646449504	302	42.25	20	302	5	287	4.0e-71	261	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646449505	306	44.3	1	306	1	315	1.0e-84	306	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646449506	547	41.99	6	546	2	562	0.0e+00	464	COG4166	ABC-type oligopeptide transport system, periplasmic component	562
646449507	214	45.41	7	213	3	203	9.0e-42	163	COG2095	Small neutral amino acid transporter SnatA, MarC family	203
646449508	900	47.33	451	862	1	377	9.0e-124	438	COG1454	Alcohol dehydrogenase, class IV	377
646449509	199	50.78	1	192	3	194	9.0e-74	269	COG1435	Thymidine kinase	201
646449510	135	68.22	7	135	1	127	8.0e-31	125	COG2916	DNA-binding protein H-NS	128
646449511	303	56.71	5	300	1	290	3.0e-115	407	COG1210	UTP-glucose-1-phosphate uridylyltransferase	291
646449513	302	38.26	1	286	7	280	5.0e-55	208	COG1752	Predicted acylesterase/phospholipase RssA, containd patatin domain	306
646449514	155	49.68	1	155	1	151	1.0e-47	182	COG3012	Uncharacterized conserved protein YchJ, contains N- and C-terminal SEC-C domains	151
646449515	283	51.4	3	283	2	287	3.0e-110	391	COG0788	Formyltetrahydrofolate hydrolase	287
646449517	206	47.06	1	203	5	208	2.0e-52	198	COG2860	Uncharacterized membrane protein YeiH	209
646449518	268	47.78	1	268	1	261	1.0e-91	329	COG0708	Exonuclease III	261
646449520	640	33.99	1	608	1	557	0.0e+00	537	COG0550	DNA topoisomerase IA	570
646449521	183	29.03	1	167	3	188	4.0e-17	81.2	COG0778	Nitroreductase	207
646449522	616	36.51	272	582	4	317	2.0e-68	254	COG0616	Periplasmic serine protease, ClpP class	317
646449523	339	36.73	1	333	17	351	5.0e-86	311	COG0252	L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D	351
646449524	212	32.09	1	211	4	201	5.0e-33	134	COG1335	Nicotinamidase-related amidase	205
646449525	91	71.11	1	88	1	90	9.0e-29	118	COG3139	Uncharacterized conserved protein YeaC, DUF1315 family	90
646449526	138	56.67	12	131	11	130	1.0e-51	195	COG0229	Peptide methionine sulfoxide reductase MsrB	140
646449527	331	66.97	2	331	1	332	0.0e+00	479	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	335
646449528	290	48.62	5	290	3	286	2.0e-86	312	COG0676	D-hexose-6-phosphate mutarotase	287
646449529	283	38.08	1	275	2	267	1.0e-69	257	COG0656	Aldo/keto reductase, related to diketogulonate reductase	280
646449530	249	41.98	9	249	16	258	3.0e-55	208	COG3713	Outer membrane scaffolding protein for murein synthesis, MipA/OmpV family	258
646449531	644	70.88	1	644	1	649	0.0e+00	916	COG2766	Predicted Ser/Thr protein kinase	649
646449532	431	70.89	7	431	1	422	0.0e+00	580	COG2718	Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family	423
646449537	250	27.8	10	247	1	241	2.0e-39	156	COG1414	DNA-binding transcriptional regulator, IclR family	246
646449538	130	39.62	20	121	18	123	4.0e-21	93.8	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
646449539	278	32.96	11	268	7	265	9.0e-36	144	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646449540	246	44.65	4	217	7	221	3.0e-48	185	COG0765	ABC-type amino acid transport system, permease component	222
646449541	214	47.32	7	210	13	217	1.0e-49	189	COG0765	ABC-type amino acid transport system, permease component	222
646449542	245	61.25	4	243	1	240	2.0e-104	372	COG1126	ABC-type polar amino acid transport system, ATPase component	240
646449543	423	24.8	45	423	16	368	6.0e-40	158	COG3616	D-serine deaminase, pyridoxal phosphate-dependent	368
646449544	169	54.27	1	164	1	164	1.0e-57	215	COG1528	Ferritin	167
646449545	292	34.72	6	291	2	286	2.0e-28	119	COG1276	Putative copper export protein	289
646449546	126	38.79	12	126	12	125	1.0e-21	95.8	COG2372	Copper-binding protein CopC (methionine-rich)	127
646449549	683	54.63	1	678	4	681	0.0e+00	874	COG1770	Protease II	682
646449550	392	71.07	1	392	1	394	0.0e+00	630	COG0027	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	394
646449551	213	54.59	4	209	2	207	4.0e-63	234	COG0800	2-keto-3-deoxy-6-phosphogluconate aldolase	211
646449552	491	56.17	5	489	3	482	0.0e+00	701	COG0364	Glucose-6-phosphate 1-dehydrogenase	483
646449553	289	45.88	1	278	3	281	1.0e-73	269	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
646449554	480	52.81	2	479	1	477	0.0e+00	580	COG0469	Pyruvate kinase	477
646449557	328	38.89	14	318	2	307	7.0e-87	314	COG1560	Lauroyl/myristoyl acyltransferase	308
646449558	472	30.49	130	455	3	274	2.0e-35	143	COG0739	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain	277
646449559	341	54.38	8	338	7	317	3.0e-111	395	COG4531	ABC-type Zn2+ transport system, periplasmic component/surface adhesin	318
646449560	252	45.1	1	236	1	254	2.0e-74	272	COG1121	ABC-type Mn2+/Zn2+ transport system, ATPase component	254
646449561	261	44.57	1	258	10	267	9.0e-45	173	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	274
646449562	336	71.04	4	331	1	328	0.0e+00	546	COG2255	Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit	332
646449563	205	48.08	1	205	1	201	3.0e-63	234	COG0632	Holliday junction resolvasome RuvABC DNA-binding subunit	201
646449564	173	60.62	5	163	1	160	1.0e-58	218	COG0817	Holliday junction resolvasome RuvABC endonuclease subunit	160
646449565	247	60.33	1	241	1	241	9.0e-99	353	COG0217	Transcriptional and/or translational regulatory protein YebC/TACO1	241
646449566	149	22.63	1	136	6	141	1.0e-10	59.2	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
646449567	596	63.28	1	586	1	585	0.0e+00	933	COG0173	Aspartyl-tRNA synthetase	585
646449568	270	35.84	1	265	3	263	1.0e-48	186	COG1801	Uncharacterized conserved protein YecE, DUF72 family	263
646449569	131	66.93	1	127	5	131	5.0e-38	150	COG3788	Uncharacterized membrane protein YecN, MAPEG domain	131
646449573	254	48.16	1	243	1	240	4.0e-76	277	COG3142	Copper homeostasis protein CutC	241
646449574	190	61.36	10	185	10	185	1.0e-65	242	COG3102	Uncharacterized conserved protein YecM, predicted metalloenzyme	185
646449575	576	40.68	1	576	1	577	0.0e+00	617	COG0018	Arginyl-tRNA synthetase	577
646449576	530	34.88	190	508	66	408	5.0e-35	142	COG0840	Methyl-accepting chemotaxis protein	408
646449577	511	54.28	1	510	7	518	3.0e-126	445	COG0728	Peptidoglycan biosynthesis protein MviN/MurJ, putative lipid II flippase	518
646449578	307	26.67	1	305	1	330	1.0e-43	170	COG0673	Predicted dehydrogenase	342
646449579	217	70.97	1	216	1	215	2.0e-78	284	COG3132	Uncharacterized conserved protein YceH, UPF0502 family	215
646449580	194	29.35	12	194	4	186	5.0e-26	110	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646449581	401	20.42	63	392	65	390	9.0e-11	61.8	COG2814	Predicted arabinose efflux permease, MFS family	394
646449582	215	58.6	1	215	1	215	2.0e-75	274	COG2999	Glutaredoxin 2	215
646449584	192	41.03	1	180	7	199	2.0e-35	142	COG3381	Cytoplasmic chaperone TorD involved in molybdoenzyme TorA maturation	204
646449585	245	31.67	2	235	1	237	3.0e-47	181	COG1387	Histidinol phosphatase or related hydrolase of the PHP family	237
646449589	251	38.1	1	251	1	252	1.0e-56	213	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646449591	212	31.92	1	195	16	228	3.0e-32	131	COG3719	Ribonuclease I	249
646449593	370	37.36	7	359	6	340	6.0e-74	271	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646449594	134	39.47	8	121	5	118	4.0e-27	113	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646449595	569	38.37	3	342	1	316	1.0e-52	201	COG2132	Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA)	451
646449596	340	22.73	58	307	48	288	6.0e-20	91.9	COG1181	D-alanine-D-alanine ligase and related ATP-grasp enzymes	317
646449597	437	22.07	34	400	5	372	5.0e-31	129	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
646449602	1478	83.2	1	1476	1	1476	0.0e+00	2143	COG3096	Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655	1480
646449603	242	76.57	3	241	1	238	9.0e-103	366	COG3095	Chromosome condensin MukBEF, MukE localization factor	238
646449604	440	86.36	1	440	1	440	0.0e+00	739	COG3006	Chromosome condensin MukBEF complex, kleisin-like MukF subunit	440
646449605	266	24.05	6	232	9	231	2.0e-11	63	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	243
646449606	259	31.54	16	253	1	223	1.0e-24	107	COG1434	Uncharacterized SAM-binding protein YcdF, DUF218 family	223
646449609	250	66.8	1	250	2	245	6.0e-104	370	COG1212	CMP-2-keto-3-deoxyoctulosonic acid synthetase	247
646449610	60	71.93	1	57	1	57	2.0e-18	84.1	COG2835	Uncharacterized conserved protein YbaR, Trm112 family	60
646449611	337	55.49	1	313	4	319	2.0e-105	375	COG1663	Tetraacyldisaccharide-1-P 4'-kinase	336
646449612	582	40.84	10	582	1	567	0.0e+00	485	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
646449613	785	33.45	490	771	3	292	3.0e-61	230	COG2333	Metal-dependent hydrolase, beta-lactamase superfamily II	293
646449615	112	83.33	5	106	3	104	5.0e-32	129	COG2926	Uncharacterized conserved protein YeeX, DUF496 family	109
646449616	476	70.11	1	475	2	475	0.0e+00	755	COG2925	Exonuclease I	475
646449617	453	24.33	5	437	1	443	8.0e-30	125	COG0531	Amino acid transporter	466
646449619	243	29.74	10	240	7	231	7.0e-36	144	COG5581	c-di-GMP-binding flagellar brake protein YcgR, contains PilZNR and PilZ domains	233
646449620	302	47.31	32	301	7	285	3.0e-61	228	COG1767	Triphosphoribosyl-dephospho-CoA synthetase	288
646449621	180	42.07	11	174	11	174	2.0e-41	162	COG3697	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase)	182
646449622	509	68.78	18	506	24	513	0.0e+00	765	COG3051	Citrate lyase, alpha subunit	513
646449623	296	45.1	12	295	1	281	1.0e-78	286	COG2301	Citrate lyase beta subunit	283
646449624	96	50.52	1	96	1	97	6.0e-25	105	COG3052	Citrate lyase, gamma subunit	98
646449625	349	50.91	17	345	11	338	6.0e-113	400	COG3053	Citrate lyase synthetase	352
646449626	294	40.17	57	278	44	265	7.0e-61	227	COG0179	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	266
646449627	455	39.07	28	454	13	438	6.0e-96	344	COG3493	Na+/citrate or Na+/malate symporter	438
646449628	546	39.59	2	532	7	535	3.0e-121	429	COG3290	Sensor histidine kinase regulating citrate/malate metabolism	537
646449629	235	38.39	11	234	2	224	4.0e-59	221	COG4565	Response regulator of citrate/malate metabolism	224
646449630	653	38.01	262	607	38	408	5.0e-50	192	COG0840	Methyl-accepting chemotaxis protein	408
646449631	273	23.49	2	266	1	296	3.0e-24	105	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646449632	299	57.58	5	299	1	290	2.0e-104	372	COG0040	ATP phosphoribosyltransferase	290
646449633	436	53.74	11	433	1	425	0.0e+00	562	COG0141	Histidinol dehydrogenase	425
646449634	356	39.72	6	354	1	354	2.0e-87	316	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
646449635	355	62.56	164	355	1	195	2.0e-83	302	COG0131	Imidazoleglycerol phosphate dehydratase HisB	195
646449636	196	56.22	1	196	2	202	2.0e-78	285	COG0118	Imidazoleglycerol phosphate synthase glutamine amidotransferase subunit HisH	204
646449637	245	52.85	1	245	3	241	3.0e-80	291	COG0106	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase	241
646449638	258	54.62	1	258	1	256	5.0e-110	390	COG0107	Imidazole glycerol phosphate synthase subunit HisF	256
646449639	204	54.13	1	108	2	109	2.0e-39	155	COG0139	Phosphoribosyl-AMP cyclohydrolase	111
646449641	94	49.46	1	93	2	93	1.0e-28	117	COG0776	Bacterial nucleoid DNA-binding protein	94
646449642	569	60.62	13	562	1	541	0.0e+00	611	COG0539	Ribosomal protein S1	541
646449643	228	59.01	4	224	3	221	1.0e-80	292	COG0283	Cytidylate kinase	222
646449644	429	48.04	3	426	2	425	0.0e+00	497	COG0128	5-enolpyruvylshikimate-3-phosphate synthase	428
646449645	361	61.81	1	361	3	365	0.0e+00	525	COG1932	Phosphoserine aminotransferase	365
646449646	587	45.13	1	418	4	396	9.0e-118	417	COG1944	Ribosomal protein S12 methylthiotransferase accessory factor YcaO	398
646449647	285	51.42	5	285	1	264	9.0e-69	253	COG2116	Formate/nitrite transporter FocA, FNT family	265
646449648	760	67.37	2	759	1	755	0.0e+00	1126	COG1882	Pyruvate-formate lyase	755
646449649	246	36.84	1	246	15	257	3.0e-72	264	COG1180	Pyruvate-formate lyase-activating enzyme	260
646449650	370	24.2	147	357	22	225	2.0e-12	66.9	COG2801	Transposase InsO and inactivated derivatives	232
646449651	309	24.33	6	303	1	296	3.0e-25	109	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449652	382	20.16	14	381	14	394	2.0e-09	57.5	COG2814	Predicted arabinose efflux permease, MFS family	394
646449653	302	28.47	8	296	7	297	8.0e-32	130	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449654	291	23.56	41	229	30	218	4.0e-17	82.2	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646449655	214	47.62	1	209	1	208	5.0e-58	217	COG3531	Predicted protein-disulfide isomerase , contains CxxC motif	212
646449656	201	25.37	1	199	1	203	2.0e-22	99.1	COG0625	Glutathione S-transferase	211
646449657	204	42.11	3	190	7	193	2.0e-39	155	COG3381	Cytoplasmic chaperone TorD involved in molybdoenzyme TorA maturation	204
646449658	431	59.22	1	431	1	426	0.0e+00	594	COG0172	Seryl-tRNA synthetase	429
646449659	447	63.41	4	442	1	435	0.0e+00	640	COG2256	Replication-associated recombination protein RarA (DNA-dependent ATPase)	436
646449660	204	45.24	1	203	4	211	7.0e-43	167	COG2834	Outer membrane lipoprotein-sorting protein	211
646449661	1235	37.11	580	1233	209	856	0.0e+00	520	COG1674	DNA segregation ATPase FtsK/SpoIIIE and related proteins	858
646449662	164	49.35	8	161	2	154	7.0e-38	150	COG1522	DNA-binding transcriptional regulator, Lrp family	154
646449663	318	53	4	318	1	305	2.0e-94	338	COG0492	Thioredoxin reductase	305
646449664	588	52.83	23	586	1	557	0.0e+00	630	COG4988	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components	559
646449665	579	59.03	7	577	1	571	0.0e+00	613	COG4987	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components	573
646449666	242	58.45	13	229	3	220	3.0e-83	301	COG2360	Leu/Phe-tRNA-protein transferase	221
646449667	72	72.22	1	72	1	72	1.0e-25	107	COG0361	Translation initiation factor IF-1	75
646449668	758	47.95	1	745	1	785	0.0e+00	871	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
646449669	106	59.43	1	106	2	107	1.0e-34	137	COG2127	ATP-dependent Clp protease adapter protein ClpS	107
646449670	73	58.21	1	67	1	67	3.0e-23	99.8	COG1278	Cold shock protein, CspA family	67
646449671	553	45.27	1	553	1	580	0.0e+00	488	COG3593	Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains	581
646449672	550	45	1	548	4	560	0.0e+00	655	COG1151	Hydroxylamine reductase (hybrid-cluster protein)	576
646449673	334	35.74	5	275	1	266	2.0e-57	216	COG1018	Ferredoxin-NADP reductase	266
646449674	489	24.82	7	285	1	275	3.0e-26	113	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
646449675	290	42.59	16	280	4	257	7.0e-66	244	COG3023	N-acetyl-anhydromuramyl-L-alanine amidase AmpD	257
646449676	108	57.55	1	106	1	106	4.0e-32	129	COG0393	Uncharacterized conserved protein YbjQ, UPF0145 family	108
646449677	249	83.88	8	249	1	242	1.0e-120	425	COG4161	ABC-type arginine transport system, ATPase component	242
646449678	243	40.38	1	243	4	265	7.0e-45	174	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646449679	238	50.85	4	237	7	230	9.0e-72	263	COG4215	ABC-type arginine transport system, permease component	230
646449680	223	54.26	1	221	6	228	7.0e-69	253	COG4160	ABC-type arginine/histidine transport system, permease component	228
646449681	244	39.85	1	244	4	266	2.0e-45	175	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646449682	376	35.9	2	368	68	432	6.0e-91	328	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
646449684	281	45.79	1	272	2	267	4.0e-57	215	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
646449685	319	48.63	23	314	1	281	3.0e-75	275	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
646449686	375	51.65	13	375	1	352	2.0e-124	438	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
646449687	369	48.65	1	369	4	363	5.0e-98	351	COG0687	Spermidine/putrescine-binding periplasmic protein	363
646449689	300	35.87	1	289	1	314	6.0e-65	241	COG0189	Glutathione synthase/RimK-type ligase, ATP-grasp superfamily	318
646449690	240	29.61	1	181	2	207	4.0e-22	98.5	COG0778	Nitroreductase	207
646449691	85	37.04	4	84	4	79	1.0e-16	78.1	COG0695	Glutaredoxin	80
646449694	562	50.36	5	558	1	543	0.0e+00	572	COG2985	Uncharacterized membrane protein YbjL, putative transporter	544
646449695	256	36.61	3	256	1	252	8.0e-57	213	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646449696	402	49.48	14	397	11	389	1.0e-116	413	COG1686	D-alanyl-D-alanine carboxypeptidase	389
646449697	272	16.12	21	272	16	280	3.0e-12	66.3	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646449698	205	32.5	2	197	1	199	7.0e-33	133	COG0625	Glutathione S-transferase	211
646449699	375	46.09	30	370	59	394	3.0e-90	325	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646449700	467	39.2	33	467	2	436	0.0e+00	495	COG0621	tRNA A37 methylthiotransferase MiaB	437
646449701	252	61.67	1	225	13	234	5.0e-83	300	COG2949	Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin	235
646449702	382	42.12	2	379	16	393	1.0e-67	250	COG2311	Uncharacterized membrane protein YeiB	394
646449703	222	46.97	25	220	1	195	2.0e-65	242	COG0302	GTP cyclohydrolase I	195
646449704	561	39.26	192	515	60	408	2.0e-53	204	COG0840	Methyl-accepting chemotaxis protein	408
646449705	553	39.84	177	515	45	408	1.0e-53	204	COG0840	Methyl-accepting chemotaxis protein	408
646449706	553	39.56	177	515	45	408	7.0e-50	192	COG0840	Methyl-accepting chemotaxis protein	408
646449707	542	36.44	176	515	44	408	2.0e-44	174	COG0840	Methyl-accepting chemotaxis protein	408
646449709	287	36.08	1	284	1	289	4.0e-34	138	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449710	373	71	4	372	1	366	0.0e+00	575	COG1062	Zn-dependent alcohol dehydrogenase	366
646449711	281	38.39	1	278	3	312	1.0e-69	256	COG0627	S-formylglutathione hydrolase FrmB	316
646449713	362	35.83	6	358	2	355	7.0e-79	287	COG0371	Glycerol dehydrogenase or related enzyme, iron-containing ADH family	360
646449714	503	46.36	9	500	9	500	0.0e+00	530	COG1129	ABC-type sugar transport system, ATPase component	500
646449715	335	41.38	19	335	2	311	3.0e-49	189	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646449719	582	29.14	15	557	12	551	1.0e-83	304	COG3882	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis	574
646449720	341	25.25	1	298	2	283	2.0e-33	136	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
646449721	395	43.99	1	389	1	391	8.0e-68	251	COG2814	Predicted arabinose efflux permease, MFS family	394
646449722	490	54.02	5	487	31	514	0.0e+00	615	COG0833	Amino acid permease	541
646449723	292	35.27	3	288	1	289	7.0e-39	154	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449724	358	46.2	13	354	2	334	3.0e-78	285	COG2855	Uncharacterized membrane protein YadS	334
646449725	285	46.45	1	280	1	276	4.0e-94	337	COG0648	Endonuclease IV	280
646449727	562	63.34	226	560	1	339	3.0e-99	356	COG1299	Phosphotransferase system, fructose-specific IIC component	343
646449728	312	47.42	4	312	1	310	1.0e-107	383	COG1105	Fructose-1-phosphate kinase or kinase (PfkB)	310
646449729	381	59.15	2	143	1	142	1.0e-50	193	COG4668	Mannitol/fructose-specific phosphotransferase system, IIA domain	142
646449730	393	21.76	4	388	2	383	7.0e-10	58.7	COG2814	Predicted arabinose efflux permease, MFS family	394
646449732	190	33.83	1	133	3	131	5.0e-29	121	COG0231	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)	131
646449733	325	30.61	3	324	1	315	8.0e-61	227	COG0523	GTPase, G3E family	323
646449734	191	33.5	2	182	1	197	1.0e-26	113	COG0791	Cell wall-associated hydrolase, NlpC family	197
646449735	603	27.8	1	596	7	562	6.0e-85	308	COG4166	ABC-type oligopeptide transport system, periplasmic component	562
646449736	364	75.34	1	364	1	364	0.0e+00	578	COG4174	ABC-type microcin C transport system, permease component YejB	364
646449737	341	71.18	1	340	1	340	0.0e+00	523	COG4239	ABC-type microcin C transport system, permease component YejE	341
646449738	530	66.04	1	529	1	530	0.0e+00	789	COG4172	ABC-type microcin C transport system, duplicated ATPase component YejF	534
646449741	393	21.41	11	393	14	390	2.0e-19	90.7	COG2814	Predicted arabinose efflux permease, MFS family	394
646449742	232	42.02	1	229	3	240	1.0e-67	249	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
646449744	586	34.63	1	368	33	400	8.0e-76	278	COG1061	Superfamily II DNA or RNA helicase	442
646449745	95	50.53	1	95	1	93	2.0e-22	97.6	COG1825	Ribosomal protein L25 (general stress protein Ctc)	93
646449746	405	22.09	58	382	63	397	9.0e-10	58.3	COG2223	Nitrate/nitrite transporter NarK	417
646449747	245	36.99	1	245	2	243	5.0e-54	204	COG3279	DNA-binding response regulator, LytR/AlgR family	244
646449748	570	41.79	4	550	1	549	0.0e+00	582	COG3275	Sensor histidine kinase, LytS/YehU family	557
646449749	336	77.91	1	335	1	335	0.0e+00	527	COG3081	Nucleoid-associated protein YejK (function unknown)	335
646449750	76	67.12	1	73	1	72	4.0e-21	93.2	COG3082	Uncharacterized conserved protein YejL, UPF0352 family	74
646449751	590	57.14	1	590	1	600	0.0e+00	693	COG3083	Membrane-anchored periplasmic protein YejM, alkaline phosphatase superfamily	600
646449753	416	23.62	94	390	3	304	3.0e-14	73.5	COG0582	Integrase	309
646449755	70	30.77	1	65	6	69	5.0e-08	49.5	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
646449757	280	36.52	35	149	1	98	3.0e-18	85.7	COG3561	Phage anti-repressor protein	110
646449761	899	36.94	403	896	62	561	5.0e-113	402	COG5519	Uncharcterized protein, DUF927 family	562
646449763	564	35.46	352	492	35	171	1.0e-22	101	COG4678	Muramidase (phage lambda lysozyme)	180
646449768	158	17.76	2	150	10	158	3.0e-06	45	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646449772	142	39.32	2	118	1	117	4.0e-33	133	COG1393	Arsenate reductase and related proteins, glutaredoxin family	117
646449773	427	45.05	1	423	3	423	9.0e-91	327	COG1055	Na+/H+ antiporter NhaD or related arsenite permease	424
646449779	121	31.82	29	116	23	109	4.0e-11	60.4	COG5513	Predicted secreted protein	113
646449782	113	69.37	1	111	1	111	1.0e-28	118	COG3136	Uncharacterized membrane protein, GlpM family	111
646449783	162	37.09	1	148	1	146	4.0e-22	97.4	COG0071	Molecular chaperone IbpA, HSP20 family	146
646449784	435	21.34	16	411	12	401	7.0e-14	72.2	COG1457	Purine-cytosine permease or related protein	442
646449785	335	43.61	13	333	1	310	1.0e-86	313	COG1984	Allophanate hydrolase subunit 2	314
646449786	294	33.06	8	252	1	219	4.0e-54	205	COG2049	Allophanate hydrolase subunit 1	223
646449789	260	47.01	4	252	3	251	3.0e-86	311	COG1540	Lactam utilization protein B (function unknown)	252
646449790	304	31.86	3	294	2	291	1.0e-34	140	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449791	393	35.44	1	393	1	394	1.0e-63	237	COG2807	Cyanate permease	395
646449792	164	35.66	32	159	1	126	5.0e-13	67.6	COG1846	DNA-binding transcriptional regulator, MarR family	126
646449793	171	34.17	1	171	1	199	9.0e-21	93.2	COG3637	Opacity protein and related surface antigens	199
646449794	293	59.31	5	292	4	292	1.0e-66	246	COG5006	Threonine/homoserine efflux transporter RhtA	292
646449795	167	35.71	17	167	4	156	5.0e-34	137	COG0783	DNA-binding ferritin-like protein (oxidative damage protectant)	156
646449796	248	36.84	1	246	1	266	6.0e-38	150	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646449797	219	47.96	1	218	1	220	2.0e-51	195	COG0765	ABC-type amino acid transport system, permease component	222
646449798	240	64.17	1	240	2	240	1.0e-107	382	COG1126	ABC-type polar amino acid transport system, ATPase component	240
646449801	621	14.7	15	555	1	539	3.0e-25	110	COG1164	Oligoendopeptidase F	598
646449802	322	29.32	1	319	2	318	3.0e-65	242	COG0547	Anthranilate phosphoribosyltransferase	338
646449803	705	32.28	13	699	2	643	4.0e-115	409	COG1199	Rad3-related DNA helicase	654
646449805	771	34.83	51	457	1	388	7.0e-83	302	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
646449806	446	34.97	8	443	1	445	1.0e-109	390	COG0160	4-aminobutyrate aminotransferase or related aminotransferase	447
646449807	258	39.92	1	238	1	233	3.0e-52	198	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646449808	228	25.51	10	196	7	201	1.0e-19	89.9	COG0625	Glutathione S-transferase	211
646449809	319	32.72	1	318	2	315	6.0e-63	234	COG1686	D-alanyl-D-alanine carboxypeptidase	389
646449810	257	58.71	41	240	5	204	3.0e-84	304	COG1636	Predicted ATPase, Adenine nucleotide alpha hydrolases (AANH) superfamily	204
646449811	179	33.9	8	178	1	175	4.0e-30	124	COG1437	Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function)	178
646449812	135	24.82	3	112	1	137	1.0e-07	49.1	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646449813	311	40.38	1	311	11	318	4.0e-79	288	COG0042	tRNA-dihydrouridine synthase	323
646449814	531	35.14	1	531	3	554	2.0e-97	350	COG0747	ABC-type transport system, periplasmic component	556
646449815	413	37.05	6	410	4	414	8.0e-99	354	COG2195	Di- or tripeptidase	414
646449817	320	20	3	307	2	292	1.0e-06	47.2	COG0697	Permease of the drug/metabolite transporter (DMT) superfamily	292
646449818	254	33.64	138	247	16	125	6.0e-20	91.1	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646449820	452	45.93	1	449	29	479	2.0e-121	429	COG0513	Superfamily II DNA and RNA helicase	513
646449821	334	29.43	3	282	12	287	2.0e-32	133	COG1566	Multidrug resistance efflux pump	352
646449822	583	46.88	331	551	4	227	2.0e-71	264	COG1131	ABC-type multidrug transport system, ATPase component	293
646449823	396	29.97	98	394	4	282	9.0e-22	98.4	COG0842	ABC-type multidrug transport system, permease component	286
646449824	368	32.32	71	366	1	282	5.0e-22	99.2	COG0842	ABC-type multidrug transport system, permease component	286
646449825	256	37.4	11	256	8	257	1.0e-51	196	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	259
646449826	403	30.67	1	361	52	424	4.0e-55	208	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
646449827	236	48.12	1	234	1	228	2.0e-38	152	COG0670	Integral membrane protein, interacts with FtsH	233
646449828	344	37.82	1	340	3	346	2.0e-84	306	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
646449829	530	34.59	32	530	13	539	8.0e-72	264	COG1178	ABC-type Fe3+ transport system, permease component	540
646449830	338	24.01	47	338	1	299	7.0e-41	161	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
646449831	150	47.3	1	148	2	149	3.0e-51	194	COG0314	Molybdopterin synthase catalytic subunit	149
646449832	81	47.62	1	81	1	84	3.0e-17	80.4	COG1977	Molybdopterin converting factor, small subunit	84
646449833	160	68.35	1	158	1	157	2.0e-62	231	COG0315	Molybdenum cofactor biosynthesis enzyme	157
646449834	170	48.21	5	170	2	168	1.0e-47	182	COG0521	Molybdopterin biosynthesis enzyme MoaB	169
646449835	329	48.32	4	329	1	322	5.0e-106	378	COG2896	Molybdenum cofactor biosynthesis enzyme MoaA	322
646449838	335	44.19	1	335	3	345	3.0e-72	265	COG1294	Cytochrome bd-type quinol oxidase, subunit 2	346
646449839	469	51.02	3	439	1	442	0.0e+00	502	COG1271	Cytochrome bd-type quinol oxidase, subunit 1	457
646449840	306	38.83	3	302	1	309	2.0e-70	259	COG0391	Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family	323
646449842	670	71.19	1	670	1	663	0.0e+00	1123	COG0556	Excinuclease UvrABC helicase subunit UvrB	663
646449843	226	49.56	1	226	1	223	9.0e-71	259	COG0132	Dethiobiotin synthetase	223
646449845	384	43.59	1	384	1	388	2.0e-118	419	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
646449846	345	59.76	3	328	10	335	1.0e-125	443	COG0502	Biotin synthase or related enzyme	335
646449847	430	46.62	1	424	1	444	0.0e+00	540	COG0161	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	449
646449849	520	26.77	1	454	16	518	4.0e-66	245	COG1022	Long-chain acyl-CoA synthetase (AMP-forming)	613
646449850	301	15.79	13	284	15	260	7.0e-06	45	COG2175	Taurine dioxygenase, alpha-ketoglutarate-dependent	286
646449853	259	30.51	136	252	6	123	8.0e-14	71	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646449855	654	31.06	76	495	1	353	2.0e-44	174	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
646449856	136	44.83	5	120	1	116	4.0e-30	123	COG1380	Putative effector of murein hydrolase LrgA, UPF0299 family	128
646449857	232	53.07	1	228	3	230	1.0e-63	236	COG1346	Putative effector of murein hydrolase	230
646449858	295	40.77	52	172	7	134	9.0e-30	124	COG0295	Cytidine deaminase	134
646449859	565	35.08	50	561	1	432	0.0e+00	461	COG0281	Malic enzyme	432
646449860	411	47.79	1	406	1	404	6.0e-127	447	COG0303	Molybdopterin biosynthesis enzyme	404
646449861	252	49.21	3	250	1	254	2.0e-73	268	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
646449862	131	32.54	5	130	3	128	4.0e-31	126	COG1607	Acyl-CoA hydrolase	157
646449863	350	17.71	1	279	4	284	2.0e-11	64	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646449864	184	28.57	1	184	3	207	4.0e-20	91.3	COG0655	Multimeric flavodoxin WrbA	207
646449868	258	58.5	1	249	5	256	2.0e-81	295	COG3228	Mlc titration factor MtfA, regulates ptsG expression	266
646449870	460	21.88	1	443	3	440	9.0e-22	98.3	COG0531	Amino acid transporter	466
646449872	379	27.55	11	373	6	330	2.0e-51	196	COG2423	Ornithine cyclodeaminase/archaeal alanine dehydrogenase, mu-crystallin family	330
646449873	140	23.85	1	127	1	129	5.0e-15	73.8	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
646449874	430	32	15	430	2	381	3.0e-45	176	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
646449875	303	27.48	5	299	1	297	2.0e-25	110	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449876	328	19.1	6	322	2	314	4.0e-21	95.8	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646449878	310	30.24	7	294	1	284	2.0e-25	110	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449879	302	35.91	1	284	2	299	5.0e-48	185	COG0331	Malonyl CoA-acyl carrier protein transacylase	310
646449881	319	26.56	1	318	1	309	2.0e-20	93.1	COG0679	Predicted permease	311
646449883	277	28.4	5	249	54	293	2.0e-42	166	COG0777	Acetyl-CoA carboxylase beta subunit	294
646449885	285	34.07	16	275	8	280	1.0e-36	147	COG1767	Triphosphoribosyl-dephospho-CoA synthetase	288
646449887	322	36.09	5	168	3	159	1.0e-28	121	COG0835	Chemotaxis signal transduction protein	165
646449888	206	30	6	206	7	213	3.0e-38	151	COG2964	Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains	220
646449889	322	45.09	1	322	1	326	3.0e-106	378	COG1171	Threonine dehydratase	347
646449891	306	21.57	1	289	1	300	9.0e-14	71.1	COG0657	Acetyl esterase/lipase	312
646449892	596	54.95	1	555	1	538	0.0e+00	700	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
646449893	306	49.09	32	306	22	288	1.0e-66	246	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646449894	323	48.92	1	322	1	317	2.0e-82	299	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646449895	319	42.99	2	313	1	310	5.0e-80	291	COG1957	Inosine-uridine nucleoside N-ribohydrolase	311
646449896	347	45.25	3	306	2	303	8.0e-86	310	COG1957	Inosine-uridine nucleoside N-ribohydrolase	311
646449897	294	35.81	1	294	2	296	5.0e-61	228	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646449898	513	30.66	3	510	19	549	1.0e-76	281	COG0747	ABC-type transport system, periplasmic component	556
646449899	296	25.75	4	296	1	295	3.0e-26	112	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449900	259	42.52	6	259	1	251	5.0e-62	231	COG2134	CDP-diacylglycerol pyrophosphatase	252
646449902	223	57.14	6	222	6	222	9.0e-70	256	COG2011	ABC-type methionine transport system, permease component	222
646449903	263	61.16	1	239	1	242	2.0e-96	345	COG1135	ABC-type methionine transport system, ATPase component	339
646449904	268	49.81	1	265	3	267	9.0e-78	283	COG1464	ABC-type metal ion transport system, periplasmic component/surface antigen	268
646449905	344	45.85	4	326	3	322	2.0e-98	353	COG3491	Isopenicillin N synthase and related dioxygenases	322
646449906	264	33.72	1	256	1	231	3.0e-32	132	COG3416	Uncharacterized protein	233
646449907	471	37.02	288	468	1	177	1.0e-37	151	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646449908	250	26.38	1	250	4	241	3.0e-22	99.1	COG1651	Protein-disulfide isomerase	244
646449910	443	28.57	14	437	1	387	5.0e-50	192	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
646449913	2860	39.47	1774	2858	2	1052	0.0e+00	880	COG3459	Cellobiose phosphorylase	1056
646449914	268	24.09	2	267	34	332	2.0e-39	156	COG4870	Cysteine protease, C1A family	372
646449915	426	20.05	12	382	9	360	7.0e-07	48.7	COG2223	Nitrate/nitrite transporter NarK	417
646449916	709	37.73	5	707	3	681	0.0e+00	641	COG3345	Alpha-galactosidase	687
646449917	343	33.33	4	340	1	333	4.0e-62	231	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646449918	213	55.02	1	207	1	208	1.0e-58	219	COG2864	Cytochrome b subunit of formate dehydrogenase	218
646449919	307	43.38	21	238	2	202	2.0e-58	219	COG0437	Fe-S-cluster-containing dehydrogenase component	203
646449920	1015	28.38	2	735	1	598	2.0e-97	350	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
646449921	866	69.87	1	853	1	841	0.0e+00	1330	COG1049	Aconitase B	852
646449922	180	39.52	8	174	8	174	3.0e-41	161	COG3697	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase)	182
646449923	509	68.98	18	506	24	513	0.0e+00	770	COG3051	Citrate lyase, alpha subunit	513
646449924	296	45.1	12	295	1	281	1.0e-78	286	COG2301	Citrate lyase beta subunit	283
646449925	96	50.52	1	96	1	97	6.0e-25	105	COG3052	Citrate lyase, gamma subunit	98
646449926	349	51.08	22	345	16	338	8.0e-113	400	COG3053	Citrate lyase synthetase	352
646449927	294	36.76	21	278	1	265	5.0e-61	228	COG0179	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	266
646449928	414	21.69	21	396	11	382	3.0e-19	89.9	COG2814	Predicted arabinose efflux permease, MFS family	394
646449929	363	49.07	1	354	3	374	5.0e-113	401	COG2828	2-Methylaconitate cis-trans-isomerase PrpF (2-methyl citrate pathway)	378
646449930	308	34.36	3	290	1	287	2.0e-45	176	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449931	355	32.69	71	326	5	252	8.0e-43	168	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
646449932	341	36.56	23	341	133	449	6.0e-64	238	COG2239	Mg/Co/Ni transporter MgtE (contains CBS domain)	451
646449934	225	39.91	6	223	10	220	4.0e-49	187	COG1285	Uncharacterized membrane protein YhiD, involved in acid resistance	221
646449935	207	43.9	38	201	34	195	7.0e-33	133	COG0684	Regulator of RNase E activity RraA	210
646449936	281	51.55	2	259	1	258	4.0e-94	337	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
646449937	349	43.21	30	348	8	330	1.0e-53	203	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
646449938	340	45.57	17	338	7	331	1.0e-54	207	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
646449939	300	32.21	30	292	52	311	2.0e-38	152	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
646449940	630	23.26	6	623	9	596	2.0e-55	210	COG4264	Siderophore synthetase component	602
646449941	258	36.25	1	251	2	252	8.0e-56	210	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	255
646449942	618	31.41	20	611	10	598	9.0e-109	388	COG4264	Siderophore synthetase component	602
646449944	417	30.69	9	394	15	394	3.0e-68	252	COG0019	Diaminopimelate decarboxylase	394
646449945	629	24.16	1	571	7	575	6.0e-53	202	COG4264	Siderophore synthetase component	602
646449946	704	18.56	8	704	33	768	2.0e-33	138	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
646449947	464	46.06	28	457	23	446	0.0e+00	500	COG0160	4-aminobutyrate aminotransferase or related aminotransferase	447
646449948	298	38.81	19	284	19	283	9.0e-51	193	COG3639	ABC-type phosphate/phosphonate transport system, permease component	283
646449949	288	36.49	1	284	13	282	8.0e-52	197	COG3639	ABC-type phosphate/phosphonate transport system, permease component	283
646449950	310	35.33	1	309	2	298	2.0e-64	239	COG3221	ABC-type phosphate/phosphonate transport system, periplasmic component	299
646449951	286	48.66	25	284	1	250	4.0e-87	314	COG3638	ABC-type phosphate/phosphonate transport system, ATPase component	258
646449952	244	30.12	1	239	9	258	7.0e-31	127	COG1235	Phosphoribosyl 1,2-cyclic phosphodiesterase	269
646449953	188	50	1	176	4	180	2.0e-49	188	COG3709	Ribose 1,5-bisphosphokinase PhnN	192
646449954	389	62.43	12	389	1	377	0.0e+00	512	COG3454	Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase PhnM	377
646449955	240	69.83	9	240	3	234	8.0e-99	353	COG4778	Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnL	235
646449956	271	78.35	22	270	3	256	8.0e-117	413	COG4107	ABC-type phosphonate transport system, ATPase component	258
646449957	284	83.93	1	280	6	285	0.0e+00	528	COG3627	Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase	291
646449958	363	73.95	1	356	1	357	0.0e+00	552	COG3626	Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI	367
646449959	191	49.22	1	190	4	196	1.0e-53	202	COG3625	Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH	196
646449960	149	50.67	1	148	2	151	3.0e-41	160	COG3624	Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG	151
646449961	239	37.34	8	239	5	236	4.0e-47	181	COG2188	DNA-binding transcriptional regulator, GntR family	236
646449962	304	35.37	7	293	2	293	2.0e-41	162	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449963	248	37.8	3	247	2	251	3.0e-45	175	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646449966	473	47.17	31	454	2	401	0.0e+00	463	COG4992	Acetylornithine/succinyldiaminopimelate/putrescine aminotransferase	404
646449967	478	46.95	7	478	1	469	0.0e+00	482	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646449968	453	56.31	9	451	1	436	0.0e+00	542	COG2704	Anaerobic C4-dicarboxylate transporter	436
646449969	329	26.57	1	318	4	330	1.0e-39	157	COG0673	Predicted dehydrogenase	342
646449970	439	50.12	1	429	1	415	2.0e-105	376	COG1301	Na+/H+-dicarboxylate symporter	415
646449971	317	29.33	1	298	1	294	7.0e-34	138	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449973	92	55.56	1	81	1	75	1.0e-19	88	COG0298	Hydrogenase maturation factor	82
646449974	208	46.84	1	188	1	156	1.0e-37	149	COG1142	Fe-S-cluster-containing hydrogenase component 2	165
646449975	679	36.52	16	521	7	496	4.0e-70	259	COG0651	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit	504
646449976	315	46.73	10	313	7	309	6.0e-56	211	COG0650	Formate hydrogenlyase subunit 4	309
646449977	479	36.42	5	478	1	473	1.0e-77	284	COG1009	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit	606
646449978	216	42.86	1	216	2	218	8.0e-37	146	COG4237	Hydrogenase-4 membrane subunit HyfE	218
646449979	548	36.94	1	500	1	494	7.0e-61	228	COG0651	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit	504
646449980	575	56.38	185	558	8	382	0.0e+00	484	COG3261	Ni,Fe-hydrogenase III large subunit	382
646449981	189	32.48	1	150	19	171	4.0e-28	117	COG1143	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)	172
646449982	262	61.9	29	175	1	147	1.0e-61	229	COG3260	Ni,Fe-hydrogenase III small subunit	148
646449984	164	35.67	17	164	6	160	3.0e-22	98.5	COG0680	Ni,Fe-hydrogenase maturation factor	160
646449986	180	48.89	1	180	1	165	7.0e-42	163	COG1142	Fe-S-cluster-containing hydrogenase component 2	165
646449987	716	41.47	1	699	261	957	0.0e+00	683	COG3383	Predicted molibdopterin-dependent oxidoreductase YjgC	978
646449988	722	47.83	194	717	33	549	0.0e+00	509	COG3604	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains	550
646449989	429	43.06	5	420	7	412	4.0e-90	325	COG1301	Na+/H+-dicarboxylate symporter	415
646449990	297	24.66	5	292	1	289	2.0e-29	123	COG0583	DNA-binding transcriptional regulator, LysR family	297
646449991	238	29.91	4	224	3	224	8.0e-49	186	COG1794	Aspartate/glutamate racemase	230
646449992	357	42.17	6	332	1	330	2.0e-73	269	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646449993	1036	42.73	53	930	6	808	0.0e+00	680	COG3250	Beta-galactosidase/beta-glucuronidase	808
646449995	423	19.6	105	401	29	309	1.0e-11	64.6	COG0582	Integrase	309
646449996	80	34.85	1	66	1	66	2.0e-10	57.7	COG1826	Sec-independent protein translocase protein TatA	94
646449998	125	34.04	27	119	2	95	2.0e-12	64.9	COG5470	Uncharacterized conserved protein, DUF1330 family	96
646449999	297	34.9	5	294	2	288	2.0e-38	153	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450000	231	44.78	1	225	1	229	3.0e-56	211	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646450001	462	32.37	156	462	34	336	6.0e-34	139	COG0642	Signal transduction histidine kinase	336
646450003	374	27.41	50	374	1	299	5.0e-25	108	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
646450004	219	19.23	36	217	2	147	1.0e-07	50	COG0716	Flavodoxin	151
646450006	247	29.06	55	247	2	187	2.0e-27	115	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	189
646450007	253	47.62	3	253	2	245	1.0e-66	246	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
646450008	380	39.62	3	361	1	357	2.0e-86	312	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646450010	337	40.41	1	335	1	325	6.0e-68	251	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646450011	331	40.68	1	319	1	316	6.0e-86	311	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646450012	225	31.65	1	216	1	202	3.0e-36	144	COG1182	FMN-dependent NADH-azoreductase	202
646450013	197	33.33	2	197	1	189	1.0e-30	126	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	189
646450014	300	35.94	171	298	1	127	4.0e-20	92.2	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646450016	64	52.46	1	61	8	68	7.0e-16	75.3	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
646450019	283	26.19	6	283	1	292	1.0e-28	120	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450020	287	23.51	21	283	28	285	4.0e-09	55.7	COG5006	Threonine/homoserine efflux transporter RhtA	292
646450024	914	31.02	114	911	20	789	0.0e+00	480	COG3451	Type IV secretory pathway, VirB4 component	796
646450027	354	16.56	32	328	72	380	6.0e-07	48.8	COG3704	Type IV secretory pathway, VirB6 components	406
646450029	227	28.44	7	222	22	232	7.0e-31	127	COG3736	Type IV secretory pathway, component VirB8	239
646450030	301	21.74	2	298	8	262	1.0e-22	100	COG3504	Type IV secretory pathway, VirB9 components	265
646450031	413	25.07	62	411	23	360	3.0e-32	133	COG2948	Type IV secretory pathway, VirB10 components	360
646450034	339	29.02	14	325	18	309	1.0e-43	170	COG0630	Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase	312
646450040	315	46.6	31	313	2	295	1.0e-74	273	COG4227	Antirestriction protein ArdC	316
646450043	258	38.58	6	250	3	251	4.0e-44	171	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646450045	353	39.83	5	349	5	339	2.0e-101	362	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
646450046	319	27.48	5	301	2	296	4.0e-29	122	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450047	420	20.48	1	415	2	405	2.0e-32	133	COG1819	UDP:flavonoid glycosyltransferase YjiC, YdhE family	406
646450048	587	48.67	27	587	10	539	0.0e+00	613	COG0405	Gamma-glutamyltranspeptidase	539
646450049	524	36.45	117	497	4	408	2.0e-48	187	COG0840	Methyl-accepting chemotaxis protein	408
646450050	338	35.44	6	336	2	313	2.0e-77	282	COG1619	Muramoyltetrapeptide carboxypeptidase LdcA (peptidoglycan recycling)	313
646450051	294	26.19	6	290	1	292	1.0e-28	120	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450052	389	32.31	8	386	2	388	2.0e-83	302	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
646450053	258	34.57	1	255	4	268	2.0e-36	145	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646450056	181	37.57	5	181	2	175	2.0e-30	125	COG0431	NAD(P)H-dependent FMN reductase	184
646450057	276	53.11	18	258	1	239	2.0e-82	299	COG0007	Uroporphyrinogen-III methylase (siroheme synthase)	244
646450058	882	32.17	1	692	38	763	0.0e+00	461	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
646450059	1392	48.23	414	1228	1	793	0.0e+00	969	COG1251	NAD(P)H-nitrite reductase, large subunit	793
646450060	264	45.95	5	263	2	248	3.0e-87	315	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
646450061	309	36.29	50	304	1	250	2.0e-45	176	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	258
646450062	428	28.13	15	369	1	335	1.0e-50	194	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	335
646450064	465	44.27	11	463	1	445	6.0e-65	241	COG1538	Outer membrane protein TolC	457
646450065	1055	58.07	1	1032	1	1008	0.0e+00	1002	COG0841	Multidrug efflux pump subunit AcrB	1009
646450066	381	36.93	1	367	7	371	2.0e-27	117	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646450067	197	20.21	1	191	1	193	3.0e-10	58.5	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646450068	410	27.97	32	342	34	338	2.0e-16	80.2	COG2814	Predicted arabinose efflux permease, MFS family	394
646450070	314	60.9	1	310	1	305	8.0e-105	373	COG3058	Formate dehydrogenase maturation protein FdhE	308
646450071	433	18.88	8	429	14	437	8.0e-21	95.3	COG2271	Sugar phosphate permease	448
646450072	210	57.21	1	205	1	208	5.0e-65	240	COG2864	Cytochrome b subunit of formate dehydrogenase	218
646450073	300	44.5	21	238	2	202	3.0e-59	222	COG0437	Fe-S-cluster-containing dehydrogenase component	203
646450074	1016	27.92	2	735	1	598	9.0e-99	355	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
646450075	475	36.4	1	474	1	459	5.0e-108	385	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
646450076	241	38.25	34	214	11	190	1.0e-38	153	COG0518	GMP synthase - Glutamine amidotransferase domain	198
646450078	766	46.14	12	763	1	750	0.0e+00	841	COG0068	Hydrogenase maturation factor HypF (carbamoyltransferase)	750
646450079	342	52.31	8	342	1	339	1.0e-98	352	COG0309	Hydrogenase maturation factor	339
646450080	371	56.49	1	369	1	363	0.0e+00	504	COG0409	Hydrogenase maturation factor	364
646450081	95	57.33	1	75	1	71	2.0e-18	84.2	COG0298	Hydrogenase maturation factor	82
646450082	408	46.15	191	394	1	201	1.0e-68	253	COG0378	Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase	202
646450083	114	54.39	1	114	1	113	2.0e-31	127	COG0375	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)	115
646450085	166	38.36	1	157	2	160	5.0e-31	127	COG0680	Ni,Fe-hydrogenase maturation factor	160
646450086	568	54.48	2	568	1	545	0.0e+00	661	COG0374	Ni,Fe-hydrogenase I large subunit	545
646450087	399	53.6	3	390	2	399	2.0e-89	322	COG5557	Ni/Fe-hydrogenase 2 integral membrane subunit HybB	401
646450088	339	32.46	37	227	11	173	5.0e-37	148	COG0437	Fe-S-cluster-containing dehydrogenase component	203
646450089	375	48.91	1	368	1	354	5.0e-120	424	COG1740	Ni,Fe-hydrogenase I small subunit	355
646450090	530	42.99	1	530	3	530	0.0e+00	582	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646450091	293	38.46	2	293	1	291	7.0e-59	220	COG0384	Predicted epimerase YddE/YHI9, PhzF superfamily	291
646450092	485	45.3	4	481	1	470	6.0e-97	348	COG1007	NADH:ubiquinone oxidoreductase subunit 2 (chain N)	475
646450093	563	50.59	51	556	2	493	0.0e+00	530	COG1008	NADH:ubiquinone oxidoreductase subunit 4 (chain M)	497
646450094	616	42.6	4	612	1	606	9.0e-123	434	COG1009	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit	606
646450095	100	61	1	100	1	100	1.0e-25	107	COG0713	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)	100
646450096	183	40.24	1	163	4	166	8.0e-25	106	COG0839	NADH:ubiquinone oxidoreductase subunit 6 (chain J)	166
646450097	180	42.68	10	172	12	170	3.0e-40	157	COG1143	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)	172
646450098	324	54.71	1	322	1	329	4.0e-103	368	COG1005	NADH:ubiquinone oxidoreductase subunit 1 (chain H)	332
646450099	908	38.09	1	783	1	693	0.0e+00	712	COG1034	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)	693
646450100	449	57.51	4	429	2	423	0.0e+00	649	COG1894	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit (chain F)	424
646450101	176	48.08	21	176	2	157	2.0e-58	218	COG1905	NADH:ubiquinone oxidoreductase 24 kD subunit (chain E)	160
646450102	599	56.64	201	599	1	398	0.0e+00	608	COG0649	NADH:ubiquinone oxidoreductase 49 kD subunit (chain D)	398
646450103	224	56.28	17	214	1	194	7.0e-73	266	COG0377	NADH:ubiquinone oxidoreductase 20 kD subunit (chhain B) or related Fe-S oxidoreductase	194
646450104	147	43.44	4	125	1	122	2.0e-32	131	COG0838	NADH:ubiquinone oxidoreductase subunit 3 (chain A)	123
646450105	309	28.42	11	274	1	276	6.0e-31	128	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450106	404	37.13	8	402	1	392	2.0e-97	349	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
646450107	199	39.09	1	195	3	193	5.0e-43	167	COG1896	5'-deoxynucleotidase YfbR and related HD superfamily hydrolases	193
646450108	611	21.02	22	611	1	458	2.0e-48	187	COG0471	Di- and tricarboxylate transporter	461
646450109	218	37.21	3	212	2	216	4.0e-36	144	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
646450110	164	79.27	1	164	5	168	8.0e-74	269	COG3013	Uncharacterized protein YfbU, UPF0304 family	168
646450111	151	71.81	3	151	1	149	1.0e-58	219	COG3092	Uncharacterized membrane protein YfbV, UPF0208 family	149
646450112	400	55.78	4	399	1	393	0.0e+00	567	COG0282	Acetate kinase	396
646450113	713	56.75	391	711	1	325	2.0e-117	416	COG0280	Phosphotransacetylase	327
646450114	204	20.53	10	147	3	150	2.0e-07	49.1	COG1443	Isopentenyldiphosphate isomerase	185
646450115	183	39.68	1	181	2	172	1.0e-38	152	COG0622	Predicted phosphodiesterase	172
646450116	209	36.76	1	198	1	197	9.0e-37	146	COG0625	Glutathione S-transferase	211
646450117	302	55.93	3	297	1	294	8.0e-114	403	COG1090	NAD dependent epimerase/dehydratase family enzyme	297
646450118	257	78.8	4	253	5	253	2.0e-117	415	COG4598	ABC-type histidine transport system, ATPase component	256
646450119	238	60.18	7	232	1	226	7.0e-79	287	COG4160	ABC-type arginine/histidine transport system, permease component	228
646450120	229	54.82	1	225	2	229	2.0e-74	271	COG4215	ABC-type arginine transport system, permease component	230
646450121	259	32.6	1	259	1	270	2.0e-36	145	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646450122	189	62.63	1	188	2	188	3.0e-77	281	COG0163	3-polyprenyl-4-hydroxybenzoate decarboxylase	191
646450123	505	55.31	1	485	4	470	0.0e+00	640	COG0034	Glutamine phosphoribosylpyrophosphate amidotransferase	470
646450124	163	44.17	1	162	1	163	2.0e-28	118	COG1286	Uncharacterized membrane protein, required for colicin V production	182
646450125	294	42.71	1	292	1	226	4.0e-29	122	COG3147	Cell division protein DedD (periplasmic protein involved in septation)	226
646450126	422	46.23	7	417	1	424	2.0e-128	452	COG0285	Folylpolyglutamate synthase/Dihydropteroate synthase	427
646450127	303	65.85	1	285	1	287	5.0e-124	437	COG0777	Acetyl-CoA carboxylase beta subunit	294
646450128	221	41.95	15	218	1	203	3.0e-38	151	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
646450129	292	53.41	14	277	3	266	1.0e-95	343	COG0101	tRNA U38,U39,U40 pseudouridine synthase TruA	266
646450130	336	41.67	4	331	1	334	4.0e-91	328	COG0136	Aspartate-semialdehyde dehydrogenase	334
646450131	377	35.47	1	295	2	323	6.0e-55	208	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
646450132	463	32.27	150	458	20	327	2.0e-34	140	COG0642	Signal transduction histidine kinase	336
646450133	224	44.93	1	218	1	226	6.0e-50	190	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646450134	325	37.42	1	325	1	319	2.0e-77	282	COG3181	Tripartite-type tricarboxylate transporter, receptor component TctC	319
646450136	505	55.6	1	499	1	497	0.0e+00	566	COG3333	TctA family transporter	504
646450138	406	46.49	1	404	2	411	2.0e-119	422	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646450139	675	40.78	1	255	1	252	5.0e-82	299	COG4121	tRNA U34 5-methylaminomethyl-2-thiouridine-forming methyltransferase MnmC	252
646450140	555	35.23	152	512	24	408	1.0e-40	161	COG0840	Methyl-accepting chemotaxis protein	408
646450142	209	26.24	5	202	4	202	4.0e-23	101	COG0625	Glutathione S-transferase	211
646450143	225	31.25	20	225	11	183	1.0e-19	89.8	COG0693	Putative intracellular protease/amidase	188
646450144	474	34.3	5	445	33	468	3.0e-91	329	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646450145	297	27.46	1	294	1	293	3.0e-26	112	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450147	187	79.66	11	187	3	179	4.0e-86	310	COG3101	Elongation factor P hydroxylase (EF-P beta-lysylation pathway)	180
646450148	266	36.47	7	255	3	256	2.0e-20	92.8	COG0730	Uncharacterized membrane protein YfcA	258
646450149	276	59.12	6	276	8	281	9.0e-104	370	COG3770	Murein endopeptidase	284
646450150	361	61.58	2	361	1	366	0.0e+00	552	COG0082	Chorismate synthase	369
646450151	310	41.38	14	301	1	279	6.0e-66	244	COG2890	Methylase of polypeptide chain release factors	280
646450152	180	52.2	1	176	1	182	6.0e-52	196	COG2840	DNA-nicking endonuclease, Smr domain	184
646450153	166	39.88	1	157	2	162	9.0e-34	136	COG2062	Phosphohistidine phosphatase SixA	163
646450155	730	41.98	319	607	2	293	1.0e-83	304	COG1250	3-hydroxyacyl-CoA dehydrogenase	307
646450156	439	33.72	14	437	1	391	4.0e-59	222	COG0183	Acetyl-CoA acetyltransferase	392
646450157	98	65.31	1	98	1	98	4.0e-28	116	COG3691	Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family	98
646450158	421	48.42	3	421	1	440	3.0e-115	408	COG2067	Long-chain fatty acid transport protein	440
646450159	523	38.74	28	499	4	429	3.0e-113	402	COG0579	L-2-hydroxyglutarate oxidase LhgO	429
646450160	253	52.99	4	251	6	249	3.0e-77	281	COG2853	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, lipoprotein component MlaA	250
646450163	268	43.91	2	268	5	274	4.0e-70	257	COG2503	Predicted secreted acid phosphatase	274
646450165	348	56.04	46	343	22	319	2.0e-102	365	COG4592	ABC-type Fe2+-enterobactin transport system, periplasmic component	319
646450166	426	21.03	21	403	13	389	1.0e-07	51.7	COG2814	Predicted arabinose efflux permease, MFS family	394
646450167	345	44.41	20	344	1	330	5.0e-52	198	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
646450168	344	55.07	1	344	1	345	4.0e-79	288	COG4779	ABC-type enterobactin transport system, permease component	346
646450169	265	49.81	4	260	2	258	9.0e-95	339	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
646450170	2902	39.76	1837	2485	2	642	2.0e-121	432	COG1020	Non-ribosomal peptide synthetase component F	642
646450171	72	62.9	7	68	4	65	4.0e-19	86.2	COG3251	Uncharacterized conserved protein YbdZ, MbtH family	71
646450172	430	35.15	135	424	20	296	5.0e-49	188	COG2382	Enterochelin esterase or related enzyme	299
646450173	736	29.17	21	736	11	768	3.0e-64	240	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
646450174	395	43.42	19	389	44	423	7.0e-108	384	COG1169	Isochorismate synthase EntC	423
646450175	542	62.73	1	530	4	535	0.0e+00	741	COG1021	Non-ribosomal peptide synthetase component E (peptide arylation enzyme)	542
646450176	291	68.06	1	216	1	216	1.0e-92	333	COG1535	Isochorismate hydrolase	218
646450177	252	36.78	5	249	1	251	3.0e-39	155	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646450178	153	31.39	16	151	1	137	2.0e-27	115	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
646450179	352	42.43	1	352	3	360	8.0e-89	320	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646450180	190	41.28	18	182	4	175	4.0e-39	154	COG3545	Predicted esterase of the alpha/beta hydrolase fold	181
646450182	283	45.19	13	281	2	247	8.0e-35	140	COG1989	Prepilin signal peptidase PulO (type II secretory pathway) or related peptidase	254
646450183	162	33.76	4	160	24	179	7.0e-17	80.1	COG3149	Type II secretory pathway, component PulM	181
646450184	400	26.14	7	397	1	388	7.0e-48	184	COG3297	Type II secretory pathway, component PulL	390
646450185	368	31.87	1	357	1	312	2.0e-48	186	COG3156	Type II secretory pathway, component PulK	323
646450186	253	29.53	8	199	3	190	6.0e-27	114	COG4795	Type II secretory pathway, component PulJ	194
646450189	153	40.69	3	136	5	149	2.0e-22	98.2	COG2165	Type II secretory pathway, pseudopilin PulG	149
646450190	408	43.98	1	407	1	397	3.0e-100	359	COG1459	Type II secretory pathway, component PulF	397
646450191	498	54.08	10	497	15	500	0.0e+00	567	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646450192	713	29.27	13	666	18	563	1.0e-86	314	COG1450	Type II secretory pathway component GspD/PulD (secretin)	587
646450193	272	24.03	30	268	28	275	1.0e-29	123	COG3031	Type II secretory pathway, component PulC	275
646450196	413	41.54	14	395	5	390	7.0e-106	377	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
646450197	286	39.15	3	277	2	276	4.0e-64	238	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
646450198	802	27.62	34	782	67	808	2.0e-92	334	COG3264	Small-conductance mechanosensitive channel	835
646450200	401	19.23	84	387	1	309	1.0e-10	61.1	COG0582	Integrase	309
646450201	370	24.2	147	357	22	225	2.0e-12	66.9	COG2801	Transposase InsO and inactivated derivatives	232
646450202	192	17.19	1	192	4	194	1.0e-07	49.6	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646450203	479	42.7	11	474	3	463	9.0e-129	454	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646450204	291	34.97	17	291	10	311	5.0e-68	251	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646450205	216	26.36	1	215	6	221	2.0e-20	92.3	COG0300	Short-chain dehydrogenase	265
646450206	192	21.28	1	188	3	188	1.0e-09	56.2	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646450207	320	29.8	4	300	2	296	1.0e-32	134	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450208	382	38.82	1	382	1	384	9.0e-102	363	COG1979	Alcohol dehydrogenase YqhD, Fe-dependent ADH family	384
646450209	310	23.45	1	306	3	306	1.0e-22	100	COG0679	Predicted permease	311
646450210	398	20.4	2	398	1	393	4.0e-15	76.4	COG2814	Predicted arabinose efflux permease, MFS family	394
646450211	172	23.46	21	168	12	147	1.0e-07	50	COG0716	Flavodoxin	151
646450214	283	46.59	1	275	3	280	1.0e-98	352	COG0656	Aldo/keto reductase, related to diketogulonate reductase	280
646450215	329	43.75	1	316	1	315	3.0e-89	321	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646450216	349	39.37	3	347	2	339	3.0e-105	375	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
646450218	113	26.21	4	106	18	120	3.0e-18	83.8	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646450219	389	33.6	9	375	8	366	3.0e-32	132	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646450220	1042	54.45	1	1031	2	1009	0.0e+00	1052	COG0841	Multidrug efflux pump subunit AcrB	1009
646450221	297	34.01	5	294	2	288	7.0e-39	154	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450222	256	27.68	1	222	1	215	2.0e-23	103	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
646450225	276	23.53	1	265	5	251	1.0e-12	67.2	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646450226	274	23.14	28	261	4	228	4.0e-14	72.3	COG2801	Transposase InsO and inactivated derivatives	232
646450227	338	27.61	7	329	4	303	2.0e-34	140	COG3547	Transposase	303
646450228	131	25.22	16	124	1	115	2.0e-09	54.9	COG2963	Transposase and inactivated derivatives	116
646450231	294	35.96	125	292	4	181	3.0e-31	129	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646450235	544	35.81	21	530	23	544	5.0e-104	371	COG3008	Paraquat-inducible protein B	553
646450236	201	23.76	7	185	5	184	6.0e-18	84.3	COG3009	Uncharacterized lipoprotein YmbA	190
646450237	207	24.62	5	199	10	197	7.0e-10	57.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646450238	69	44.26	10	69	10	70	3.0e-13	66.5	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
646450244	291	46.15	10	291	10	295	7.0e-79	287	COG3596	Predicted GTPase	296
646450246	228	24.9	6	221	1	241	1.0e-21	96.6	COG2378	Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains	311
646450259	239	46.41	1	236	3	237	1.0e-69	256	COG0410	ABC-type branched-chain amino acid transport system, ATPase component	237
646450260	259	45.2	1	249	1	249	1.0e-69	256	COG0411	ABC-type branched-chain amino acid transport system, ATPase component	250
646450261	295	37.16	2	294	25	312	7.0e-35	141	COG4177	ABC-type branched-chain amino acid transport system, permease component	314
646450262	297	31.13	1	296	6	296	3.0e-31	129	COG0559	Branched-chain amino acid ABC-type transport system, permease component	297
646450263	375	29.86	23	362	4	347	3.0e-44	172	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	366
646450264	233	32.46	1	227	5	228	2.0e-33	136	COG1802	DNA-binding transcriptional regulator, GntR family	230
646450265	416	44.39	22	407	1	391	1.0e-111	396	COG1473	Metal-dependent amidase/aminoacylase/carboxypeptidase	392
646450266	267	36.8	1	266	1	266	1.0e-46	180	COG0345	Pyrroline-5-carboxylate reductase	266
646450267	504	32.96	8	504	21	553	6.0e-83	301	COG0747	ABC-type transport system, periplasmic component	556
646450269	327	53.44	3	317	1	315	6.0e-114	403	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
646450270	281	49.45	12	280	15	285	1.0e-63	236	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646450271	312	46.96	5	312	3	315	3.0e-82	298	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646450273	297	20.68	5	295	1	281	2.0e-18	86.3	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646450274	512	37.42	215	373	18	180	7.0e-35	142	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646450276	143	37.33	1	142	11	160	2.0e-07	48.5	COG2391	Uncharacterized membrane protein YedE/YeeE, contains two sulfur transport domains	198
646450277	109	35.71	13	109	8	105	1.0e-07	48.3	COG0640	DNA-binding transcriptional regulator, ArsR family	110
646450278	379	53.6	1	373	9	383	2.0e-119	422	COG2850	Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain	383
646450280	357	32.93	6	334	1	332	9.0e-68	251	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646450281	423	41.23	1	423	1	429	9.0e-110	390	COG4580	Maltoporin (phage lambda and maltose receptor)	429
646450282	104	39.02	25	104	1	82	2.0e-13	67.2	COG1264	Phosphotransferase system IIB components	88
646450283	685	42.57	2	682	4	672	0.0e+00	679	COG1874	Beta-galactosidase GanA	673
646450284	399	53.75	1	399	2	392	0.0e+00	523	COG3867	Arabinogalactan endo-1,4-beta-galactosidase	403
646450285	299	51.07	21	299	3	282	2.0e-92	332	COG3833	ABC-type maltose transport system, permease component	282
646450286	435	34.31	125	430	1	291	3.0e-57	216	COG1175	ABC-type sugar transport system, permease component	295
646450287	410	41.15	1	408	8	420	4.0e-100	358	COG2182	Maltose-binding periplasmic protein MalE	420
646450288	370	53.8	1	355	1	337	3.0e-128	451	COG3839	ABC-type sugar transport system, ATPase component	338
646450291	363	27.4	1	356	1	357	1.0e-46	180	COG0371	Glycerol dehydrogenase or related enzyme, iron-containing ADH family	360
646450292	404	31.61	9	389	23	371	4.0e-80	291	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646450293	468	44.85	3	468	2	463	0.0e+00	507	COG1904	Glucuronate isomerase	463
646450294	514	28.25	2	478	4	465	1.0e-75	277	COG2211	Na+/melibiose symporter or related transporter	467
646450295	485	47.89	13	483	7	473	0.0e+00	525	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
646450296	228	30.49	5	226	9	230	4.0e-36	144	COG1802	DNA-binding transcriptional regulator, GntR family	230
646450297	563	75.5	8	562	5	555	0.0e+00	958	COG2987	Urocanate hydratase	561
646450298	520	59.88	9	494	6	490	0.0e+00	601	COG2986	Histidine ammonia-lyase	498
646450299	261	53.73	4	258	2	248	4.0e-93	334	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
646450300	286	37.5	31	286	1	256	4.0e-48	185	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	258
646450301	320	25.16	14	320	15	326	1.0e-32	133	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	335
646450303	249	33.9	14	247	1	236	5.0e-55	207	COG2188	DNA-binding transcriptional regulator, GntR family	236
646450304	438	33.04	4	436	11	443	5.0e-67	248	COG3037	Ascorbate-specific PTS system EIIC-type component UlaA	481
646450305	537	34.03	14	537	9	532	2.0e-98	353	COG3290	Sensor histidine kinase regulating citrate/malate metabolism	537
646450306	215	44.34	2	213	13	222	1.0e-57	216	COG4565	Response regulator of citrate/malate metabolism	224
646450307	514	50.51	8	493	7	493	0.0e+00	580	COG2986	Histidine ammonia-lyase	498
646450308	260	65.88	3	257	1	255	5.0e-110	390	COG4598	ABC-type histidine transport system, ATPase component	256
646450309	238	51.32	2	228	1	228	2.0e-58	219	COG4160	ABC-type arginine/histidine transport system, permease component	228
646450310	240	45.41	7	233	1	229	4.0e-56	211	COG4215	ABC-type arginine transport system, permease component	230
646450311	285	27.49	1	285	3	269	4.0e-31	128	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646450312	182	32.95	14	179	17	192	3.0e-25	108	COG3758	Various environmental stresses-induced protein Ves (function unknown)	193
646450313	454	27.68	1	441	3	421	7.0e-58	218	COG0402	Cytosine/adenosine deaminase or related metal-dependent hydrolase	421
646450314	404	41.87	5	404	3	401	8.0e-99	354	COG1228	Imidazolonepropionase or related amidohydrolase	406
646450315	266	42.32	1	264	6	271	1.0e-73	269	COG3741	N-formylglutamate amidohydrolase	272
646450316	654	32.03	275	632	23	406	3.0e-39	157	COG0840	Methyl-accepting chemotaxis protein	408
646450317	289	58.3	4	286	1	283	6.0e-114	403	COG0190	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	283
646450318	70	42.86	1	70	1	70	2.0e-18	84.1	COG2501	Ribosome-associated protein YbcJ, S4-like RNA binding protein	73
646450319	461	60.94	1	461	1	464	0.0e+00	704	COG0215	Cysteinyl-tRNA synthetase	464
646450320	140	25.93	1	133	1	133	8.0e-06	43.1	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
646450321	164	51.2	1	164	1	158	4.0e-52	196	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
646450322	240	52.08	4	240	1	236	4.0e-69	254	COG2908	UDP-2,3-diacylglucosamine pyrophosphatase LpxH	237
646450323	169	66.26	7	169	2	162	2.0e-59	222	COG0041	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	162
646450324	356	45.65	1	350	1	375	4.0e-117	414	COG0026	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	375
646450325	427	37.23	17	426	7	412	1.0e-74	274	COG0814	Amino acid permease	415
646450326	456	50.18	171	451	1	262	9.0e-90	324	COG1760	L-serine deaminase	262
646450328	271	68.9	18	271	1	253	3.0e-122	431	COG1117	ABC-type phosphate transport system, ATPase component	253
646450329	548	31.5	1	271	8	280	1.0e-60	227	COG4985	ABC-type phosphate transport system, auxiliary component	289
646450330	728	44.88	1	724	2	733	0.0e+00	663	COG4590	ABC-type uncharacterized transport system, permease component	733
646450331	689	50.36	2	685	6	692	0.0e+00	867	COG0855	Polyphosphate kinase	696
646450332	509	48.48	11	497	2	492	0.0e+00	507	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	492
646450335	142	34.9	1	142	4	151	4.0e-15	74.2	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
646450337	174	22.86	3	140	7	181	8.0e-12	63.3	COG1335	Nicotinamidase-related amidase	205
646450339	219	37.12	1	219	4	232	2.0e-27	116	COG0670	Integral membrane protein, interacts with FtsH	233
646450340	119	41.35	13	116	7	108	3.0e-21	93.9	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646450341	249	36.11	3	245	2	249	7.0e-43	167	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646450342	109	81.65	1	109	3	111	3.0e-49	186	COG2920	Sulfur relay (sulfurtransferase) protein, DsrC/TusE family	111
646450343	92	47.31	1	92	1	92	9.0e-24	101	COG1254	Acylphosphatase	92
646450344	102	38.68	1	102	10	114	7.0e-25	105	COG3785	Heat shock protein HspQ	116
646450345	137	62.77	1	137	4	140	2.0e-51	194	COG1832	Predicted CoA-binding protein	140
646450346	215	36.57	6	213	4	216	4.0e-35	141	COG3110	Uncharacterized conserved protein YccT, UPF0319 family	216
646450347	152	68.09	8	148	1	141	2.0e-62	231	COG1803	Methylglyoxal synthase	142
646450349	148	68.49	1	146	1	145	1.0e-51	195	COG3304	Uncharacterized membrane protein YccF, DUF307 family	145
646450350	731	35.42	9	703	2	658	1.0e-113	404	COG1289	Uncharacterized membrane protein YccC	674
646450351	209	36.36	2	121	1	121	5.0e-18	84.6	COG3070	Transcriptional regulator of competence genes, TfoX/Sxy family	121
646450352	164	52.35	1	164	1	169	1.0e-40	159	COG5404	Cell division inhibitor SulA, prevents FtsZ ring assembly	169
646450353	354	27.18	140	345	1	190	7.0e-28	118	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
646450354	320	46.25	8	320	4	309	3.0e-78	285	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646450355	393	47.26	3	393	2	403	2.0e-110	392	COG1972	Nucleoside permease NupC	404
646450356	421	33.62	52	392	27	367	1.0e-35	144	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646450357	1046	39.27	19	1031	3	1009	0.0e+00	956	COG0841	Multidrug efflux pump subunit AcrB	1009
646450358	1029	38.33	2	1011	1	1009	0.0e+00	965	COG0841	Multidrug efflux pump subunit AcrB	1009
646450359	467	20.05	5	413	8	359	6.0e-13	69.1	COG2814	Predicted arabinose efflux permease, MFS family	394
646450360	452	34.11	151	450	35	330	1.0e-40	161	COG0642	Signal transduction histidine kinase	336
646450361	243	48.68	16	239	3	229	7.0e-61	227	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646450362	320	49.54	1	312	1	324	1.0e-109	389	COG0435	Glutathionyl-hydroquinone reductase	324
646450363	458	41.92	1	394	4	347	3.0e-112	398	COG0826	Collagenase-like protease, PrtC family	347
646450364	135	67.46	10	135	12	137	8.0e-31	126	COG3223	Phosphate starvation-inducible membrane PsiE (function unknown)	138
646450365	267	50.56	1	267	1	263	2.0e-90	326	COG0351	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	263
646450366	264	56.25	11	263	1	256	1.0e-73	269	COG2145	Hydroxyethylthiazole kinase, sugar kinase family	265
646450367	300	28.57	1	270	1	269	4.0e-38	152	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450368	550	43.12	2	546	1	551	0.0e+00	580	COG3961	TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase	557
646450369	393	44.62	4	391	3	385	1.0e-125	443	COG1168	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	388
646450370	420	21.86	34	396	37	386	5.0e-17	82.6	COG2814	Predicted arabinose efflux permease, MFS family	394
646450372	568	33.33	20	565	11	554	2.0e-105	376	COG2192	Predicted carbamoyl transferase, NodU family	555
646450374	298	29.1	7	294	1	297	3.0e-26	112	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450375	101	36.46	6	99	20	115	2.0e-16	77.4	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	124
646450378	130	19.86	1	125	2	137	6.0e-07	46.7	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646450380	396	21.3	2	395	1	390	8.0e-08	51.7	COG2814	Predicted arabinose efflux permease, MFS family	394
646450381	374	33.06	15	368	15	379	2.0e-58	220	COG3287	Uncharacterized conserved protein, contains FIST_N domain	379
646450383	365	26.58	119	316	4	225	1.0e-22	101	COG1639	HD-like signal output (HDOD) domain, no enzymatic activity	289
646450385	248	30.77	3	93	1	91	2.0e-12	66.3	COG0789	DNA-binding transcriptional regulator, MerR family	124
646450387	239	24.61	1	238	6	257	6.0e-29	121	COG0300	Short-chain dehydrogenase	265
646450388	420	43.1	1	410	9	418	3.0e-122	432	COG2907	Predicted NAD/FAD-binding protein	447
646450389	247	34.51	3	247	7	254	3.0e-51	195	COG3496	Uncharacterized conserved protein, DUF1365 family	261
646450390	408	44.88	125	407	6	283	2.0e-82	300	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	283
646450393	333	60.87	171	331	1	160	9.0e-58	217	COG3272	Uncharacterized conserved protein YbgA, DUF1722 family	163
646450394	211	40.38	1	204	4	207	3.0e-50	191	COG0288	Carbonic anhydrase	207
646450395	624	28.18	26	337	2	357	2.0e-31	131	COG3240	Phospholipase/lecithinase/hemolysin	370
646450397	129	23.85	1	127	5	132	3.0e-12	64.5	COG0824	Acyl-CoA thioesterase FadM	137
646450398	10192	47.43	4563	5216	1	641	0.0e+00	535	COG1020	Non-ribosomal peptide synthetase component F	642
646450399	554	33.7	9	554	11	540	2.0e-103	370	COG4615	ABC-type siderophore export system, fused ATPase and permease components	546
646450400	525	68.34	207	525	1	315	0.0e+00	557	COG0519	GMP synthase, PP-ATPase domain/subunit	315
646450401	487	31.36	257	476	1	170	2.0e-34	140	COG0516	IMP dehydrogenase/GMP reductase	170
646450402	462	53.71	5	449	1	440	0.0e+00	539	COG1570	Exonuclease VII, large subunit	440
646450406	498	52.83	1	474	2	444	0.0e+00	584	COG1160	Predicted GTPases	444
646450407	393	28.93	1	390	4	368	2.0e-48	186	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646450408	206	52.2	1	204	1	205	4.0e-51	194	COG2976	Putative negative regulator of RcsB-dependent stress response	207
646450409	424	50	2	424	1	429	0.0e+00	519	COG0124	Histidyl-tRNA synthetase	429
646450410	373	62.6	7	367	1	361	0.0e+00	542	COG0821	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE	361
646450411	338	36.82	16	304	3	284	4.0e-47	181	COG1426	Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains	284
646450412	251	44.69	26	250	25	250	3.0e-50	191	COG3063	Tfp pilus assembly protein PilF	250
646450413	392	57.18	25	376	1	349	0.0e+00	478	COG0820	Adenine C2-methylase RlmN of 23S rRNA A2503 and tRNA A37	349
646450414	142	61.94	3	136	2	135	3.0e-55	207	COG0105	Nucleoside diphosphate kinase	135
646450415	284	41.4	1	284	4	283	6.0e-72	264	COG2897	3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains	285
646450417	431	39.92	1	431	23	485	2.0e-123	436	COG0260	Leucyl aminopeptidase	485
646450418	66	79.69	3	66	1	64	1.0e-22	98.1	COG2975	Fe-S-cluster formation regulator IscX/YfhJ	64
646450419	111	47.17	1	104	1	102	2.0e-20	91.3	COG0633	Ferredoxin	102
646450420	616	46.82	18	602	4	579	0.0e+00	556	COG0443	Molecular chaperone DnaK (HSP70)	579
646450421	172	39.77	1	170	1	171	2.0e-25	108	COG1076	DnaJ-domain-containing proteins 1	174
646450422	107	58.33	1	107	3	110	2.0e-36	144	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
646450423	128	52.08	1	125	5	145	1.0e-36	145	COG0822	NifU homolog involved in Fe-S cluster formation	150
646450424	404	63.43	3	388	1	386	0.0e+00	577	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
646450425	164	42.28	1	148	1	149	2.0e-39	154	COG1959	DNA-binding transcriptional regulator, IscR family	150
646450426	248	51.24	1	242	1	239	2.0e-87	315	COG0565	tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase	242
646450427	267	51.54	1	258	1	260	4.0e-82	298	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
646450428	374	26.32	8	344	16	319	2.0e-34	140	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
646450429	360	42.56	28	360	2	333	1.0e-52	200	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
646450430	263	41.11	6	254	3	254	1.0e-61	230	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
646450431	373	26.89	16	342	29	319	1.0e-41	164	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
646450432	345	37.3	16	334	3	302	1.0e-62	234	COG2215	ABC-type nickel/cobalt efflux system, permease component RcnA	303
646450433	220	45.07	10	219	1	213	1.0e-61	229	COG3683	ABC-type uncharacterized transport system, periplasmic component	213
646450435	417	70.22	5	416	4	412	0.0e+00	701	COG0112	Glycine/serine hydroxymethyltransferase	413
646450436	395	60.67	1	148	1	150	1.0e-57	217	COG1017	Hemoglobin-like flavoprotein	150
646450437	392	30.37	16	392	7	344	2.0e-43	170	COG3866	Pectate lyase	345
646450438	405	28.91	26	405	5	344	7.0e-40	158	COG3866	Pectate lyase	345
646450439	385	31.78	25	385	21	344	3.0e-44	172	COG3866	Pectate lyase	345
646450440	552	18.8	278	541	10	215	7.0e-07	49.5	COG2755	Lysophospholipase L1 or related esterase	216
646450441	365	29.25	24	360	77	405	1.0e-56	214	COG4677	Pectin methylesterase and related acyl-CoA thioesterases	405
646450442	112	75.89	1	112	1	112	1.0e-39	154	COG0347	Nitrogen regulatory protein PII	112
646450443	445	45.79	3	445	1	463	0.0e+00	488	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646450445	477	28.61	139	473	2	329	2.0e-34	140	COG0642	Signal transduction histidine kinase	336
646450446	1295	39	159	964	1	730	0.0e+00	789	COG0046	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain	743
646450447	485	62.88	21	477	1	458	0.0e+00	615	COG4623	Membrane-bound lytic murein transglycosylase MltF	473
646450448	170	58.22	5	149	6	151	5.0e-51	193	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
646450449	312	64.65	11	307	2	298	8.0e-121	426	COG2103	N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase	298
646450451	728	33.19	29	717	12	696	0.0e+00	504	COG2274	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	709
646450453	505	45.81	321	498	4	181	3.0e-44	173	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646450454	263	28.03	39	262	18	251	2.0e-30	126	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
646450456	126	45.97	2	125	1	124	1.0e-37	148	COG0736	Phosphopantetheinyl transferase (holo-ACP synthase)	127
646450457	243	68.31	4	243	1	243	1.0e-96	346	COG0854	Pyridoxine 5'-phosphate synthase PdxJ	243
646450458	244	42.62	5	232	8	244	1.0e-54	206	COG1381	Recombinational DNA repair protein (RecF pathway)	251
646450459	301	54.85	3	300	1	298	4.0e-119	421	COG1159	GTPase Era, involved in 16S rRNA processing	298
646450460	226	54.59	1	224	3	230	2.0e-78	285	COG0571	dsRNA-specific ribonuclease	235
646450462	599	71.07	1	597	6	603	0.0e+00	1087	COG0481	Translation elongation factor EF-4, membrane-bound GTPase	603
646450463	156	51.01	1	149	1	149	6.0e-41	160	COG3086	Positive regulator of sigma E activity	150
646450464	316	54.09	1	314	1	318	5.0e-99	354	COG3026	Negative regulator of sigma E activity	320
646450465	221	54.63	1	216	5	213	7.0e-47	180	COG3073	Negative regulator of sigma E activity	213
646450466	191	37.1	7	191	2	181	6.0e-32	130	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646450467	534	59.05	9	532	7	508	0.0e+00	717	COG0029	Aspartate oxidase	518
646450468	253	34.71	14	253	12	248	4.0e-56	211	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	248
646450469	450	42.76	1	445	26	470	6.0e-108	384	COG0513	Superfamily II DNA and RNA helicase	513
646450470	127	84.25	1	127	1	127	1.0e-60	224	COG3445	Autonomous glycyl radical cofactor GrcA	127
646450471	228	65.77	1	222	1	222	5.0e-105	373	COG0692	Uracil DNA glycosylase	223
646450474	422	61.37	1	422	6	425	0.0e+00	625	COG2873	O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent	426
646450475	471	44.61	2	463	9	472	0.0e+00	520	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	472
646450481	144	29.84	16	137	12	133	1.0e-06	46.1	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
646450482	330	55.46	1	324	1	339	6.0e-111	393	COG1118	ABC-type sulfate/molybdate transport systems, ATPase component	345
646450483	294	56.29	5	288	1	286	5.0e-98	351	COG4208	ABC-type sulfate transport system, permease component	287
646450484	270	53.36	1	265	1	268	6.0e-68	250	COG0555	ABC-type sulfate transport system, permease component	274
646450485	336	69.23	9	333	22	346	0.0e+00	519	COG1613	ABC-type sulfate transport system, periplasmic component	348
646450486	385	60.26	5	384	2	375	3.0e-126	445	COG3835	Sugar diacid utilization regulator	376
646450487	483	42.19	7	389	1	340	4.0e-71	262	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646450488	505	33.4	2	505	1	412	3.0e-92	333	COG0232	dGTP triphosphohydrolase	412
646450489	233	54.74	1	230	3	234	1.0e-65	242	COG0775	Nucleoside phosphorylase	234
646450490	282	25.56	34	279	50	314	2.0e-30	126	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
646450491	114	55.96	6	114	2	110	5.0e-39	152	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
646450492	465	40.41	12	454	5	440	1.0e-64	241	COG0038	H+/Cl- antiporter ClcA	443
646450493	426	66.59	3	426	6	429	0.0e+00	643	COG0001	Glutamate-1-semialdehyde aminotransferase	432
646450494	847	39.51	163	812	27	656	0.0e+00	569	COG0744	Membrane carboxypeptidase (penicillin-binding protein)	661
646450495	828	42.22	2	826	42	845	0.0e+00	720	COG1643	HrpA-like RNA helicase	845
646450496	177	32.02	6	174	2	178	2.0e-32	132	COG1514	2'-5' RNA ligase	180
646450497	239	53.88	1	232	1	228	3.0e-87	314	COG1489	DNA-binding protein, stimulates sugar fermentation	235
646450498	151	54.17	32	151	1	120	3.0e-29	121	COG1734	RNA polymerase-binding transcription factor DksA	120
646450500	467	40.24	38	459	1	412	7.0e-102	364	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
646450501	162	54.09	1	159	1	158	1.0e-51	195	COG0801	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	160
646450502	264	59.7	3	263	1	263	2.0e-107	381	COG0413	Ketopantoate hydroxymethyltransferase	268
646450503	284	57.39	1	282	1	284	9.0e-113	399	COG0414	Panthothenate synthetase	285
646450504	126	57.6	2	126	1	125	1.0e-49	188	COG0853	Aspartate 1-decarboxylase	126
646450505	256	21.78	28	252	43	256	1.0e-09	57.5	COG1682	ABC-type polysaccharide/polyol phosphate export permease	263
646450506	307	38.08	1	301	1	292	4.0e-75	275	COG1131	ABC-type multidrug transport system, ATPase component	293
646450507	213	50	1	202	1	206	1.0e-63	236	COG0288	Carbonic anhydrase	207
646450508	177	63.64	1	176	3	176	3.0e-70	257	COG0634	Hypoxanthine-guanine phosphoribosyltransferase	178
646450511	355	32.77	2	347	1	352	9.0e-79	287	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
646450512	535	27.94	1	532	7	533	4.0e-49	189	COG1178	ABC-type Fe3+ transport system, permease component	540
646450514	287	52.13	3	283	1	280	1.0e-93	336	COG0421	Spermidine synthase	282
646450515	264	43.33	3	181	1	135	1.0e-37	150	COG1586	S-adenosylmethionine decarboxylase or arginine decarboxylase	136
646450517	244	37.55	1	242	8	240	3.0e-47	181	COG0847	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease	243
646450518	154	63.4	3	152	2	154	2.0e-54	204	COG0328	Ribonuclease HI	154
646450520	251	28.29	4	222	17	252	7.0e-22	97.6	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646450521	465	23.16	23	249	14	285	2.0e-11	64	COG0741	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)	296
646450522	263	40.45	1	260	41	305	1.0e-53	203	COG3021	Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily	309
646450528	857	56.26	5	854	1	780	0.0e+00	994	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
646450529	246	52.42	5	246	1	248	5.0e-82	297	COG1496	Copper oxidase (laccase) domain	249
646450530	325	46.2	6	303	1	289	1.0e-80	293	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646450531	243	50	2	242	1	234	1.0e-66	246	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	254
646450532	111	45.28	1	104	1	106	2.0e-28	117	COG1544	Ribosome-associated translation inhibitor RaiA	110
646450534	385	41.84	104	381	4	279	2.0e-89	322	COG0077	Prephenate dehydratase	279
646450535	373	31.67	100	353	4	279	2.0e-57	216	COG0287	Prephenate dehydrogenase	279
646450536	354	62.25	2	347	1	346	0.0e+00	563	COG0722	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	351
646450539	115	70.54	3	114	4	115	5.0e-42	162	COG0335	Ribosomal protein L19	115
646450540	249	58.26	1	241	1	240	2.0e-108	385	COG0336	tRNA G37 N-methylase TrmD	240
646450541	182	49.72	7	182	1	172	5.0e-54	203	COG0806	Ribosomal 30S subunit maturation factor RimM, required for 16S rRNA processing	174
646450542	82	59.76	1	82	1	81	4.0e-26	109	COG0228	Ribosomal protein S16	87
646450543	453	63.36	1	452	1	451	0.0e+00	642	COG0541	Signal recognition particle GTPase	451
646450544	264	53.58	1	264	2	264	6.0e-70	257	COG4137	ABC-type uncharacterized transport system, permease component	265
646450545	171	64.81	1	162	1	161	1.0e-70	259	COG1854	S-ribosylhomocysteine lyase LuxS, autoinducer biosynthesis	161
646450546	516	67.25	1	514	1	515	0.0e+00	744	COG2918	Gamma-glutamylcysteine synthetase	518
646450547	142	38.78	1	139	13	158	3.0e-23	100	COG1238	Uncharacterized membrane protein YqaA, SNARE-associated domain	161
646450548	189	38.71	5	186	1	185	6.0e-39	153	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
646450553	61	67.21	1	61	1	61	1.0e-19	88	COG1551	sRNA-binding carbon storage regulator CsrA	73
646450554	875	58.47	1	875	4	879	0.0e+00	1200	COG0013	Alanyl-tRNA synthetase	879
646450555	167	34.13	3	167	21	166	6.0e-24	103	COG2137	SOS response regulatory protein OraA/RecX, interacts with RecA	174
646450556	360	66.2	1	283	1	279	3.0e-88	319	COG0468	RecA/RadA recombinase	279
646450557	162	52.47	1	162	1	161	5.0e-53	200	COG1546	Nicotinamide mononucleotide (NMN) deamidase PncC	162
646450559	177	41.01	1	177	4	181	6.0e-41	160	COG3038	Cytochrome b561	181
646450560	209	38.46	3	208	2	208	2.0e-28	119	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
646450562	257	42.15	1	255	3	251	5.0e-43	168	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646450563	515	51.98	31	501	13	487	0.0e+00	623	COG0753	Catalase	496
646450566	318	34.73	8	314	18	320	2.0e-42	166	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646450567	500	49	5	500	4	499	0.0e+00	594	COG1129	ABC-type sugar transport system, ATPase component	500
646450568	345	43.08	16	331	1	309	2.0e-48	186	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646450569	330	40.06	1	311	4	309	2.0e-47	183	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646450570	473	23.22	236	442	53	223	8.0e-13	68.8	COG0688	Phosphatidylserine decarboxylase	239
646450571	459	25.81	4	417	14	432	9.0e-46	178	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646450572	347	31.36	221	338	2	116	4.0e-13	69.5	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646450574	330	42.59	15	328	1	320	5.0e-73	267	COG0523	GTPase, G3E family	323
646450575	67	67.16	1	67	1	65	1.0e-22	98.1	COG2879	Uncharacterized short protein YbdD, DUF466 family	65
646450576	715	41.74	33	706	1	574	0.0e+00	584	COG1966	Carbon starvation protein CstA	575
646450577	241	48.15	1	239	1	243	8.0e-56	210	COG3279	DNA-binding response regulator, LytR/AlgR family	244
646450578	563	61.9	3	559	1	553	0.0e+00	721	COG3275	Sensor histidine kinase, LytS/YehU family	557
646450579	257	31.06	22	256	5	236	1.0e-36	146	COG2188	DNA-binding transcriptional regulator, GntR family	236
646450580	426	23.29	7	418	1	405	4.0e-36	146	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646450581	532	28.88	3	511	2	541	2.0e-76	280	COG0747	ABC-type transport system, periplasmic component	556
646450582	315	45.37	4	314	3	315	8.0e-80	290	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646450583	275	45.59	6	275	16	287	7.0e-65	240	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646450584	558	46.48	12	546	2	536	0.0e+00	577	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
646450585	409	28.61	1	403	1	408	2.0e-45	176	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646450587	207	40.59	1	202	2	202	3.0e-54	205	COG1182	FMN-dependent NADH-azoreductase	202
646450589	345	31.45	2	333	12	328	7.0e-48	184	COG4977	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain	328
646450592	372	23.72	6	371	4	383	5.0e-30	125	COG1696	D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily	425
646450595	254	45.24	3	248	2	249	8.0e-43	167	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646450596	295	34.13	128	289	2	168	2.0e-31	129	COG0350	O6-methylguanine-DNA--protein-cysteine methyltransferase	168
646450598	94	40.45	1	88	1	89	2.0e-13	67.2	COG2026	mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system	90
646450601	810	20.71	63	754	88	738	2.0e-32	134	COG1353	CRISPR/Cas system-associated protein Cas10, large subunit of type III CRISPR-Cas systems, contains HD superfamily nuclease domain	799
646450603	245	37.67	2	218	4	210	3.0e-35	142	COG1337	CRISPR/Cas system CSM-associated protein Csm3, group 7 of RAMP superfamily	249
646450605	575	19.32	18	416	1	365	6.0e-13	69.6	COG1332	CRISPR/Cas system CSM-associated protein Csm5, group 7 of RAMP superfamily	369
646450611	417	61.15	1	417	4	417	0.0e+00	610	COG0014	Gamma-glutamyl phosphate reductase	417
646450612	367	56.64	1	367	3	369	0.0e+00	475	COG0263	Glutamate 5-kinase	369
646450615	152	18.67	1	144	14	179	5.0e-24	103	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	179
646450617	486	36.67	6	485	1	414	5.0e-108	385	COG2195	Di- or tripeptidase	414
646450618	352	41.97	2	347	1	352	5.0e-86	311	COG0389	Nucleotidyltransferase/DNA polymerase involved in DNA repair	354
646450619	241	48.39	14	230	24	240	3.0e-63	235	COG3034	Murein L,D-transpeptidase YafK	298
646450620	255	49.41	1	255	1	248	8.0e-86	309	COG0121	Predicted glutamine amidotransferase	252
646450621	193	57.54	2	179	1	176	4.0e-66	244	COG0279	Phosphoheptose isomerase	176
646450622	816	27.71	120	507	5	382	4.0e-45	177	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
646450623	400	41.21	3	380	10	387	2.0e-98	353	COG4857	5-Methylthioribose kinase, methionine salvage pathway	408
646450624	343	50.3	13	329	11	334	2.0e-103	369	COG0182	Methylthioribose-1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit	346
646450625	180	45.56	1	179	1	174	2.0e-51	195	COG1791	Acireductone dioxygenase (methionine salvage), cupin superfamily	181
646450626	236	45.41	1	216	3	219	2.0e-64	238	COG4229	Enolase-phosphatase E1 involved in merthionine salvage	229
646450627	204	32.65	10	201	12	194	8.0e-34	137	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
646450628	385	35.75	21	385	20	388	2.0e-85	309	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
646450629	255	34.59	2	253	1	265	4.0e-45	174	COG0388	Predicted amidohydrolase	274
646450632	416	22.88	14	412	2	403	4.0e-34	139	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646450633	414	36.75	11	409	3	383	4.0e-105	374	COG0075	Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG	383
646450634	243	57.26	2	242	1	240	4.0e-104	370	COG1126	ABC-type polar amino acid transport system, ATPase component	240
646450635	218	42.59	2	216	7	222	7.0e-51	193	COG0765	ABC-type amino acid transport system, permease component	222
646450636	221	45.97	7	216	8	218	1.0e-48	186	COG0765	ABC-type amino acid transport system, permease component	222
646450637	263	28.04	1	260	1	270	1.0e-29	123	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646450638	279	26.33	1	275	2	281	4.0e-45	175	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
646450639	529	36.4	6	529	13	539	6.0e-120	424	COG0405	Gamma-glutamyltranspeptidase	539
646450641	470	38.66	1	460	2	474	9.0e-100	357	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
646450643	315	23.13	11	311	1	267	2.0e-27	116	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/CDA1 family	267
646450644	245	50.88	6	232	3	230	7.0e-60	224	COG4126	Asp/Glu/hydantoin racemase	230
646450645	247	35.15	18	217	19	219	1.0e-32	133	COG1802	DNA-binding transcriptional regulator, GntR family	230
646450646	494	39.11	13	479	20	490	1.0e-120	426	COG1953	Cytosine/uracil/thiamine/allantoin permease	497
646450647	613	34.89	33	461	20	467	6.0e-84	305	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
646450648	238	31.36	4	222	1	219	1.0e-31	130	COG1802	DNA-binding transcriptional regulator, GntR family	230
646450649	400	66.41	1	396	1	386	0.0e+00	520	COG4175	ABC-type proline/glycine betaine transport system, ATPase component	386
646450650	400	62.99	103	383	9	289	4.0e-102	365	COG4176	ABC-type proline/glycine betaine transport system, permease component	290
646450651	341	28.7	10	339	2	300	6.0e-59	221	COG2113	ABC-type proline/glycine betaine transport system, periplasmic component	302
646450652	400	24.93	12	387	11	383	3.0e-23	103	COG2814	Predicted arabinose efflux permease, MFS family	394
646450653	261	47.81	30	256	10	232	3.0e-42	165	COG1296	Predicted branched-chain amino acid permease (azaleucine resistance)	238
646450655	170	31.36	44	161	11	126	7.0e-09	53.8	COG1846	DNA-binding transcriptional regulator, MarR family	126
646450656	391	44.61	11	352	5	344	3.0e-91	329	COG1566	Multidrug resistance efflux pump	352
646450658	380	37.25	127	379	6	258	3.0e-62	232	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
646450660	238	66.52	2	222	1	220	2.0e-77	282	COG3148	Uncharacterized conserved protein YfiP, DTW domain	231
646450661	888	45.21	3	626	1	598	0.0e+00	558	COG1042	Acyl-CoA synthetase (NDP forming)	598
646450662	451	24.13	2	451	32	438	5.0e-48	185	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
646450663	432	21.07	55	427	44	390	1.0e-10	61.4	COG2814	Predicted arabinose efflux permease, MFS family	394
646450671	188	52.38	1	188	1	181	1.0e-58	219	COG0241	Histidinol phosphatase or a related phosphatase	181
646450672	343	63.85	1	342	1	339	0.0e+00	477	COG1135	ABC-type methionine transport system, ATPase component	339
646450673	217	58.99	1	217	6	222	5.0e-72	263	COG2011	ABC-type methionine transport system, permease component	222
646450674	271	59	13	271	10	268	3.0e-92	331	COG1464	ABC-type metal ion transport system, periplasmic component/surface antigen	268
646450676	235	56.79	1	162	2	155	5.0e-52	197	COG1720	tRNA (Thr-GGU) A37 N-methylase	156
646450677	572	47.73	1	568	1	500	0.0e+00	610	COG0442	Prolyl-tRNA synthetase	500
646450678	330	44.2	7	322	20	336	2.0e-75	276	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
646450679	413	32.09	117	411	4	262	5.0e-33	135	COG0739	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain	277
646450680	208	53.66	4	206	1	205	1.0e-68	252	COG2518	Protein-L-isoaspartate O-methyltransferase	209
646450681	350	37.47	7	339	11	396	3.0e-85	309	COG0585	tRNA(Glu) U13 pseudouridine synthase TruD	406
646450682	165	66.46	1	158	1	158	4.0e-66	243	COG0245	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	159
646450683	235	50	10	230	4	228	3.0e-69	254	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	230
646450684	117	50	1	94	24	117	1.0e-23	101	COG2919	Cell division protein FtsB	117
646450686	216	66.15	23	216	1	195	1.0e-84	306	COG0529	Adenylylsulfate kinase or related kinase	197
646450687	475	67.13	22	453	1	431	0.0e+00	685	COG2895	Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family	431
646450688	302	39.68	1	302	11	261	2.0e-62	232	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
646450689	473	64.61	215	455	4	244	4.0e-87	315	COG0007	Uroporphyrinogen-III methylase (siroheme synthase)	244
646450690	244	40.25	16	244	10	243	3.0e-56	211	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
646450691	571	44.28	16	565	7	509	0.0e+00	545	COG0155	Sulfite reductase, beta subunit (hemoprotein)	510
646450692	606	58.42	17	606	1	587	0.0e+00	691	COG0369	Sulfite reductase, alpha subunit (flavoprotein)	587
646450694	429	26.45	1	426	8	432	1.0e-42	167	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
646450696	122	44.96	1	120	1	127	1.0e-32	131	COG0720	6-pyruvoyl-tetrahydropterin synthase	127
646450697	223	35.24	1	223	2	212	6.0e-50	190	COG0602	Organic radical activating enzyme	212
646450698	324	23.53	89	292	29	212	9.0e-15	74.5	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646450699	379	41.78	31	379	4	354	3.0e-95	342	COG4225	Rhamnogalacturonyl hydrolase YesR	357
646450700	524	27.86	1	474	4	462	1.0e-74	273	COG2211	Na+/melibiose symporter or related transporter	467
646450701	432	69.14	1	431	1	423	0.0e+00	633	COG0148	Enolase	423
646450702	545	67.59	3	543	1	533	0.0e+00	919	COG0504	CTP synthase (UTP-ammonia lyase)	533
646450704	745	53.53	9	742	1	701	0.0e+00	921	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	701
646450705	444	40.78	13	431	1	432	2.0e-113	402	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
646450706	922	36.94	253	519	78	333	2.0e-41	164	COG0642	Signal transduction histidine kinase	336
646450707	380	68.7	1	377	1	377	0.0e+00	527	COG1929	Glycerate kinase	378
646450708	294	52.1	1	285	1	286	2.0e-81	295	COG2084	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase	286
646450709	256	55.91	4	256	2	255	1.0e-97	349	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	255
646450710	446	28.4	8	415	1	371	8.0e-61	228	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646450711	453	27.71	8	415	1	372	4.0e-58	219	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646450712	450	22.72	18	435	27	433	8.0e-30	125	COG2271	Sugar phosphate permease	448
646450713	524	48.91	115	524	1	381	0.0e+00	461	COG2721	Altronate dehydratase	381
646450714	511	33.24	192	509	64	406	1.0e-43	171	COG0840	Methyl-accepting chemotaxis protein	408
646450717	73	75	1	72	1	71	1.0e-23	101	COG3530	Uncharacterized conserved protein, DUF3820 family	71
646450718	683	60	9	683	1	667	0.0e+00	958	COG0272	NAD-dependent DNA ligase	667
646450719	475	63.42	1	473	1	465	0.0e+00	718	COG2870	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase	467
646450720	949	54.99	4	948	15	954	0.0e+00	1071	COG1391	Glutamine synthetase adenylyltransferase	963
646450721	443	44.7	1	443	1	432	4.0e-100	358	COG3025	Inorganic triphosphatase YgiF, contains CYTH and CHAD domains	432
646450722	207	47.8	2	206	1	205	2.0e-57	215	COG3103	Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family	205
646450723	416	37.53	1	391	23	405	4.0e-83	302	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
646450724	273	55.15	3	273	2	268	2.0e-71	262	COG1968	Undecaprenyl pyrophosphate phosphatase UppP	270
646450725	120	48.28	1	115	2	117	1.0e-33	135	COG1539	Dihydroneopterin aldolase	121
646450726	213	51	1	193	1	200	1.0e-58	219	COG0344	Phospholipid biosynthesis protein PlsY, probable glycerol-3-phosphate acyltransferase	200
646450727	528	36.52	198	517	64	408	1.0e-42	168	COG0840	Methyl-accepting chemotaxis protein	408
646450728	176	63.43	1	175	1	171	2.0e-60	225	COG0221	Inorganic pyrophosphatase	171
646450732	343	31.94	5	343	1	349	2.0e-50	193	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
646450733	115	48.72	3	114	4	120	4.0e-25	106	COG2105	Uncharacterized conserved protein YtfP, gamma-glutamylcyclotransferase (GGCT)/AIG2-like family	120
646450734	1251	42.49	1	1251	8	1278	0.0e+00	977	COG2911	Autotransporter translocation and assembly factor TamB	1278
646450735	594	47.3	27	594	20	594	0.0e+00	567	COG0729	Outer membrane translocation and assembly module TamA	594
646450736	213	55.81	41	212	3	171	2.0e-71	262	COG0225	Peptide methionine sulfoxide reductase MsrA	174
646450737	438	36.49	1	429	3	426	3.0e-103	369	COG1253	Hemolysin or related protein, contains CBS domains	429
646450739	246	58.59	1	244	8	262	1.0e-83	303	COG1218	3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase	276
646450740	648	36.32	1	565	1	517	5.0e-120	425	COG0737	2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family	517
646450741	221	65.61	1	221	1	221	3.0e-89	321	COG2846	Iron-sulfur cluster repair protein YtfE, RIC family, contains ScdAN and hemerythrin domains	221
646450743	206	52.43	1	206	1	205	3.0e-63	234	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	205
646450744	248	37.25	46	248	43	242	2.0e-33	136	COG3061	Cell envelope opacity-associated protein A (function unknown)	242
646450745	119	45.3	1	115	1	116	1.0e-27	115	COG3189	Uncharacterized conserved protein YeaO, DUF488 family	117
646450746	311	34.34	8	303	5	291	2.0e-52	199	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646450747	348	41.57	20	345	1	331	4.0e-75	275	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646450748	634	38.13	259	608	34	408	7.0e-52	199	COG0840	Methyl-accepting chemotaxis protein	408
646450749	470	21.43	30	467	12	444	1.0e-14	74.9	COG2271	Sugar phosphate permease	448
646450751	149	57.05	1	149	1	147	1.0e-42	165	COG0359	Ribosomal protein L9	148
646450752	75	72.06	1	68	8	75	2.0e-20	90.7	COG0238	Ribosomal protein S18	75
646450753	106	67.96	1	103	1	103	3.0e-38	149	COG2965	Primosomal replication protein N	103
646450754	130	52.68	2	112	1	112	2.0e-34	137	COG0360	Ribosomal protein S6	112
646450755	249	25.09	8	249	30	298	1.0e-19	89.8	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
646450756	646	32.78	307	644	47	408	1.0e-49	191	COG0840	Methyl-accepting chemotaxis protein	408
646450759	244	47.95	1	243	20	258	6.0e-70	257	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
646450760	824	50.28	17	724	3	706	0.0e+00	776	COG0557	Exoribonuclease R	706
646450761	141	47.76	1	131	1	134	2.0e-34	137	COG1959	DNA-binding transcriptional regulator, IscR family	150
646450762	528	32.54	166	518	31	408	2.0e-47	183	COG0840	Methyl-accepting chemotaxis protein	408
646450764	413	29.62	17	403	25	400	5.0e-56	212	COG0402	Cytosine/adenosine deaminase or related metal-dependent hydrolase	421
646450766	343	58.31	1	330	3	332	8.0e-128	450	COG2805	Tfp pilus assembly protein PilT, pilus retraction ATPase	353
646450767	243	56.03	8	238	1	228	5.0e-86	311	COG0325	Uncharacterized pyridoxal phosphate-containing protein, affects Ilv metabolism, UPF0001 family	228
646450768	273	44.03	5	271	3	265	1.0e-68	253	COG0345	Pyrroline-5-carboxylate reductase	266
646450769	184	33.33	89	183	1	96	8.0e-07	47.1	COG0762	Uncharacterized conserved protein YggT, Ycf19 family	96
646450770	96	50	1	96	3	102	1.0e-25	108	COG1872	Uncharacterized conserved protein YggU, UPF0235/DUF167 family	102
646450771	197	57.14	1	195	1	191	2.0e-67	248	COG0127	Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family	194
646450772	379	44.94	6	379	34	413	7.0e-119	420	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
646450773	483	41.76	293	474	3	180	2.0e-43	170	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646450775	151	52.63	1	151	1	152	2.0e-49	188	COG2153	Predicted N-acyltransferase, GNAT family	155
646450777	732	30.8	196	715	1	527	1.0e-81	298	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646450778	300	45.14	4	289	1	286	1.0e-82	300	COG3555	Aspartyl/asparaginyl beta-hydroxylase, cupin superfamily	291
646450779	336	42.94	2	333	1	333	6.0e-88	317	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646450781	255	34.62	10	236	9	239	6.0e-42	164	COG2186	DNA-binding transcriptional regulator, FadR family	241
646450782	105	49.52	1	105	1	101	3.0e-27	113	COG1440	Phosphotransferase system cellobiose-specific component IIB	102
646450783	478	38.88	6	467	2	453	1.0e-112	400	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
646450784	448	39.39	14	442	15	432	1.0e-93	336	COG1455	Phosphotransferase system cellobiose-specific component IIC	432
646450785	108	39.22	1	102	1	102	6.0e-21	92.6	COG1447	Phosphotransferase system cellobiose-specific component IIA	105
646450786	336	39.39	2	329	1	329	2.0e-84	305	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646450787	420	39.8	16	397	17	394	2.0e-94	339	COG0019	Diaminopimelate decarboxylase	394
646450788	310	28.33	5	301	2	297	5.0e-28	118	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450789	159	38.99	1	155	1	155	5.0e-36	143	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
646450792	330	46.57	1	330	3	351	8.0e-104	370	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
646450793	260	34.94	11	258	15	260	8.0e-38	150	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
646450794	280	46.07	1	275	1	278	3.0e-76	278	COG4132	ABC-type uncharacterized transport system, permease component	282
646450796	350	25.25	52	347	1	299	6.0e-35	141	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
646450797	235	34.5	1	228	1	229	7.0e-47	180	COG2188	DNA-binding transcriptional regulator, GntR family	236
646450799	353	45.11	3	348	2	339	6.0e-114	404	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
646450800	396	37.2	21	395	12	390	7.0e-55	208	COG2814	Predicted arabinose efflux permease, MFS family	394
646450801	169	50.41	47	168	44	166	6.0e-33	133	COG4925	Uncharacterized protein	166
646450802	378	26.59	41	378	4	299	3.0e-29	122	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
646450803	294	34.02	6	293	2	288	4.0e-37	148	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450804	344	38.58	20	335	5	312	1.0e-84	306	COG0042	tRNA-dihydrouridine synthase	323
646450806	331	44.55	2	319	1	319	2.0e-79	289	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646450807	467	49.89	21	461	1	435	0.0e+00	560	COG0305	Replicative DNA helicase	435
646450808	358	51.52	1	358	2	360	7.0e-121	427	COG0787	Alanine racemase	360
646450810	255	25.28	1	255	5	267	1.0e-25	110	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646450811	457	53.54	1	450	3	454	0.0e+00	535	COG1113	L-asparagine transporter and related permeases	462
646450812	158	37.75	1	151	3	152	1.0e-25	108	COG1522	DNA-binding transcriptional regulator, Lrp family	154
646450814	397	57.07	1	396	1	395	0.0e+00	582	COG1448	Aspartate/tyrosine/aromatic aminotransferase	396
646450819	1098	22.17	175	868	1	540	1.0e-61	232	COG1203	CRISPR/Cas system-associated endonuclease/helicase Cas3	733
646450820	333	17.87	15	326	1	297	7.0e-46	177	COG1518	CRISPR/Cas system-associated endonuclease Cas1	327
646450821	556	35.29	134	516	1	408	7.0e-45	175	COG0840	Methyl-accepting chemotaxis protein	408
646450822	514	40.46	335	502	9	180	5.0e-41	162	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646450823	139	48.2	1	138	2	137	2.0e-42	164	COG0432	Thiamin phosphate synthase YjbQ, UPF0047 family	137
646450824	943	69.67	1	942	3	935	0.0e+00	1599	COG0178	Excinuclease UvrABC ATPase subunit	935
646450825	182	44.44	5	182	2	167	2.0e-39	155	COG0629	Single-stranded DNA-binding protein	167
646450829	191	23.56	12	185	10	173	7.0e-20	90.4	COG1853	NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family	176
646450839	596	20.06	14	361	8	350	6.0e-35	142	COG3500	Phage protein D	350
646450840	99	48.04	1	99	1	98	2.0e-10	57.7	COG4104	Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, incolved in TypeVI secretion	98
646450841	139	27.5	12	131	1	116	5.0e-15	73.5	COG3628	Phage baseplate assembly protein W	116
646450847	345	32.16	2	341	1	330	3.0e-59	222	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646450848	349	44.13	107	349	38	281	3.0e-56	212	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
646450849	333	42.38	34	333	8	294	1.0e-53	203	COG1175	ABC-type sugar transport system, permease component	295
646450850	366	53.67	1	353	1	338	4.0e-129	454	COG3839	ABC-type sugar transport system, ATPase component	338
646450851	367	43.3	51	361	33	347	6.0e-71	261	COG4225	Rhamnogalacturonyl hydrolase YesR	357
646450853	435	21.81	7	423	10	431	3.0e-29	123	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
646450855	297	34.03	8	290	3	290	8.0e-47	180	COG2971	BadF-type ATPase, related to human N-acetylglucosamine kinase	301
646450856	253	28.06	7	249	21	271	2.0e-25	109	COG0555	ABC-type sulfate transport system, permease component	274
646450857	311	21.36	1	303	4	258	2.0e-17	83.1	COG0725	ABC-type molybdate transport system, periplasmic component	258
646450859	233	40.53	1	221	4	230	2.0e-61	228	COG1121	ABC-type Mn2+/Zn2+ transport system, ATPase component	254
646450860	284	42.65	4	281	1	274	1.0e-34	140	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	274
646450861	292	37.59	5	292	14	302	4.0e-68	251	COG0803	ABC-type Zn uptake system ZnuABC, Zn-binding component ZnuA	303
646450863	188	34.57	1	184	14	200	2.0e-40	158	COG1611	Predicted Rossmann fold nucleotide-binding protein	205
646450864	165	28.99	4	135	1	138	7.0e-11	60.2	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646450865	274	40.16	23	270	6	253	3.0e-58	218	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646450866	326	51.07	1	326	2	326	1.0e-103	369	COG1995	4-hydroxy-L-threonine phosphate dehydrogenase PdxA	332
646450867	428	31.46	10	423	3	413	4.0e-59	222	COG3395	Uncharacterized conserved protein YgbK, DUF1537 family	413
646450868	378	35.79	1	378	4	377	4.0e-85	308	COG1454	Alcohol dehydrogenase, class IV	377
646450869	294	38.01	1	290	1	288	7.0e-69	254	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646450870	473	20.39	8	446	1	466	2.0e-24	107	COG0591	Na+/proline symporter	493
646450871	394	38.52	20	393	15	377	6.0e-63	234	COG4692	Predicted neuraminidase (sialidase)	381
646450872	157	32.08	1	153	1	154	5.0e-25	107	COG2731	Beta-galactosidase, beta subunit	154
646450873	227	30.52	1	224	2	249	4.0e-29	121	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646450874	547	29.24	162	518	26	408	4.0e-29	123	COG0840	Methyl-accepting chemotaxis protein	408
646450875	120	68.33	1	119	1	120	5.0e-39	152	COG3112	Uncharacterized protein YacL, UPF0231 family	121
646450876	865	85.02	1	861	1	852	0.0e+00	1555	COG1049	Aconitase B	852
646450877	443	27.37	1	361	3	366	9.0e-44	171	COG2079	2-methylcitrate dehydratase PrpD	453
646450878	390	24.45	111	339	9	179	1.0e-11	64.3	COG0412	Dienelactone hydrolase	236
646450879	474	52.74	3	456	1	454	0.0e+00	498	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
646450880	628	45.35	202	628	1	403	4.0e-98	352	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	404
646450881	887	75.93	1	887	1	887	0.0e+00	1507	COG2609	Pyruvate dehydrogenase complex, dehydrogenase (E1) component	887
646450882	254	40.82	1	242	1	241	7.0e-44	170	COG2186	DNA-binding transcriptional regulator, FadR family	241
646450883	448	55.46	1	447	3	451	0.0e+00	543	COG1113	L-asparagine transporter and related permeases	462
646450884	284	56.21	1	284	1	282	1.0e-71	263	COG3725	Membrane protein required for beta-lactamase induction	282
646450886	287	62.12	1	287	5	284	7.0e-82	297	COG3248	Nucleoside-specific outer membrane channel protein Tsx	284
646450887	296	52.69	22	296	5	278	1.0e-95	343	COG0157	Nicotinate-nucleotide pyrophosphorylase	280
646450888	147	32.52	3	123	4	125	1.0e-19	89.3	COG4969	Tfp pilus assembly protein, major pilin PilA	125
646450889	473	45.4	13	470	24	500	0.0e+00	469	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646450890	401	39.45	4	398	1	396	4.0e-89	322	COG1459	Type II secretory pathway, component PulF	397
646450891	346	24.15	139	345	2	168	1.0e-25	111	COG0516	IMP dehydrogenase/GMP reductase	170
646450892	208	44.78	1	201	1	201	4.0e-57	214	COG0237	Dephospho-CoA kinase	201
646450893	249	62.7	7	249	1	244	6.0e-85	307	COG4582	Cell division protein ZapD, interacts with FtsZ	244
646450894	61	63.33	1	60	5	64	5.0e-17	79.3	COG3024	Endogenous inhibitor of DNA gyrase, YacG/DUF329 family	65
646450895	143	32.56	11	132	4	129	4.0e-12	63.9	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
646450896	897	62.5	2	889	1	822	0.0e+00	1140	COG0653	Preprotein translocase subunit SecA (ATPase, RNA helicase)	822
646450898	173	30.86	2	163	1	162	6.0e-32	130	COG4701	Uncharacterized protein	162
646450899	305	70.53	1	302	1	300	0.0e+00	495	COG0774	UDP-3-O-acyl-N-acetylglucosamine deacetylase	300
646450900	383	56.97	2	337	3	338	3.0e-102	365	COG0206	Cell division GTPase FtsZ	338
646450901	418	51.43	8	418	6	418	0.0e+00	486	COG0849	Cell division ATPase FtsA	418
646450902	284	33.58	1	268	3	269	3.0e-52	198	COG1589	Cell division septal protein FtsQ	269
646450904	486	55.13	13	477	1	455	0.0e+00	606	COG0773	UDP-N-acetylmuramate-alanine ligase	459
646450905	363	45.1	6	353	1	355	1.0e-104	373	COG0707	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	357
646450906	400	45.5	29	389	13	374	6.0e-87	314	COG0772	Bacterial cell division protein FtsW, lipid II flippase	381
646450907	437	49.01	1	437	3	447	0.0e+00	486	COG0771	UDP-N-acetylmuramoylalanine-D-glutamate ligase	448
646450908	360	46.97	20	360	1	316	6.0e-62	231	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
646450909	453	47.69	2	450	1	451	0.0e+00	462	COG0770	UDP-N-acetylmuramyl pentapeptide synthase	451
646450910	494	48.84	21	493	9	475	0.0e+00	489	COG0769	UDP-N-acetylmuramyl tripeptide synthase	475
646450911	587	39.6	8	566	2	598	0.0e+00	470	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
646450912	107	68.57	1	105	1	105	9.0e-31	125	COG3116	Cell division protein FtsL, interacts with FtsB, FtsL and FtsQ	105
646450913	313	57.1	1	312	1	313	4.0e-115	408	COG0275	16S rRNA C1402 N4-methylase RsmH	314
646450914	152	52.63	1	152	1	146	2.0e-46	178	COG2001	MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity	146
646450916	334	30.72	1	329	1	327	7.0e-61	227	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646450917	163	56.79	1	162	3	163	2.0e-49	188	COG0440	Acetolactate synthase, small subunit	163
646450918	573	52.04	3	565	1	549	0.0e+00	685	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
646450919	601	42.4	8	601	15	609	0.0e+00	631	COG1022	Long-chain acyl-CoA synthetase (AMP-forming)	613
646450920	524	49.64	3	414	1	409	1.0e-125	443	COG0119	Isopropylmalate/homocitrate/citramalate synthases	409
646450921	363	57.26	2	362	1	348	0.0e+00	465	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
646450922	466	59.91	1	465	1	422	0.0e+00	647	COG0065	Homoaconitase/3-isopropylmalate dehydratase large subunit	423
646450923	200	58.21	1	200	1	191	7.0e-82	296	COG0066	3-isopropylmalate dehydratase small subunit	191
646450924	301	33.22	6	299	14	262	7.0e-43	167	COG2375	NADPH-dependent ferric siderophore reductase, contains FAD-binding and SIP domains	265
646450926	466	62.18	1	466	5	471	0.0e+00	666	COG3033	Tryptophanase	471
646450928	555	52.11	1	550	1	564	0.0e+00	589	COG4533	DNA-binding transcriptional regulator SgrR  of sgrS sRNA, contains a MarR-type HTH domain and a periplasmic-type solute-binding domain	564
646450929	327	63.36	1	327	4	336	5.0e-128	450	COG4143	ABC-type thiamine transport system, periplasmic component	336
646450930	536	38.01	1	532	1	535	3.0e-83	302	COG1178	ABC-type Fe3+ transport system, permease component	540
646450931	230	62.77	1	230	1	231	6.0e-85	307	COG3840	ABC-type thiamine transport system, ATPase component	231
646450932	554	48.46	4	552	3	550	0.0e+00	614	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
646450934	255	35.82	8	206	8	208	2.0e-31	129	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
646450938	159	35.22	1	155	1	155	9.0e-33	132	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
646450939	790	33.87	7	790	5	788	0.0e+00	617	COG0417	DNA polymerase elongation subunit (family B)	792
646450940	967	27.11	59	944	8	834	1.0e-62	235	COG0553	Superfamily II DNA or RNA helicase, SNF2 family	866
646450941	217	42.66	7	217	73	289	4.0e-58	217	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646450943	799	41.42	13	799	1	784	0.0e+00	660	COG1452	LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA)	784
646450944	430	22.03	4	340	1	320	3.0e-18	87.1	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
646450945	333	56.62	8	330	4	328	5.0e-119	421	COG1995	4-hydroxy-L-threonine phosphate dehydrogenase PdxA	332
646450946	272	51.35	11	268	4	258	2.0e-90	325	COG0030	16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity)	259
646450947	125	64	1	125	2	126	6.0e-50	189	COG2967	Uncharacterized protein affecting Mg2+/Co2+ transport	126
646450948	283	24.59	146	263	34	155	6.0e-11	61.6	COG0639	Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family	155
646450950	160	47.02	3	160	2	167	2.0e-40	158	COG0262	Dihydrofolate reductase	167
646450951	156	49.35	5	156	2	155	6.0e-30	123	COG3610	Uncharacterized membrane protein YjjB, DUF3815 family	156
646450952	257	38.93	4	244	8	250	1.0e-58	220	COG2966	Uncharacterized membrane protein YjjP, DUF1212 family	250
646450953	204	34.78	1	204	2	206	3.0e-27	115	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
646450954	1074	70.71	13	408	1	393	0.0e+00	584	COG0458	Carbamoylphosphate synthase large subunit	400
646450955	381	63.49	3	380	2	368	0.0e+00	597	COG0505	Carbamoylphosphate synthase small subunit	368
646450956	273	58.11	6	270	3	266	1.0e-98	353	COG0289	Dihydrodipicolinate reductase	266
646450957	305	46.45	3	305	2	311	3.0e-91	328	COG1957	Inosine-uridine nucleoside N-ribohydrolase	311
646450958	316	67.46	1	295	2	294	3.0e-128	451	COG0761	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH	294
646450959	152	44.44	5	148	3	145	7.0e-38	149	COG1047	FKBP-type peptidyl-prolyl cis-trans isomerase 2	174
646450960	168	47.31	1	164	2	164	5.0e-39	153	COG0597	Lipoprotein signal peptidase	167
646450961	941	51.26	2	935	1	933	0.0e+00	1274	COG0060	Isoleucyl-tRNA synthetase	933
646450962	313	51.47	1	307	1	303	2.0e-101	362	COG0196	FAD synthase	304
646450963	87	64.37	1	87	1	87	1.0e-14	71.5	COG0268	Ribosomal protein S20	88
646450964	296	21.95	4	285	1	283	1.0e-23	103	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450965	391	59.38	1	389	4	389	1.0e-115	409	COG3004	Na+/H+ antiporter NhaA	390
646450966	377	65.25	1	374	1	371	0.0e+00	526	COG0484	DnaJ-class molecular chaperone with C-terminal Zn finger domain	371
646450967	636	60.73	1	605	4	579	0.0e+00	672	COG0443	Molecular chaperone DnaK (HSP70)	579
646450968	190	65.78	6	186	19	205	1.0e-54	205	COG1584	Succinate-acetate transporter protein	207
646450969	439	19.42	72	416	63	383	4.0e-09	56.4	COG2814	Predicted arabinose efflux permease, MFS family	394
646450970	195	42.37	3	178	7	169	2.0e-46	178	COG0521	Molybdopterin biosynthesis enzyme MoaB	169
646450971	381	45.68	203	362	20	180	4.0e-36	145	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646450972	317	38.22	5	314	1	238	1.0e-66	247	COG0176	Transaldolase	239
646450973	259	66.02	1	256	1	252	2.0e-94	339	COG3022	Cytoplasmic iron level regulating protein YaaA, DUF328/UPF0246 family	253
646450974	429	31.81	1	426	1	410	3.0e-96	345	COG0498	Threonine synthase	411
646450975	309	43.37	1	309	3	298	3.0e-104	371	COG0083	Homoserine kinase	299
646450976	818	45.24	1	460	3	445	2.0e-130	460	COG0527	Aspartokinase	447
646450977	233	40.83	1	231	3	241	2.0e-55	209	COG0565	tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase	242
646450978	238	38.89	4	235	1	228	7.0e-52	197	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646450979	159	62.03	1	158	2	156	9.0e-60	222	COG3045	Periplasmic catabolite regulation protein CreA (function unknown)	165
646450980	288	36.63	6	106	21	121	2.0e-21	96.1	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646450981	216	35.9	1	193	2	195	4.0e-41	161	COG0406	Broad specificity phosphatase PhoE	208
646450982	179	48.3	1	171	1	173	3.0e-50	190	COG1986	Non-canonical (house-cleaning) NTP pyrophosphatase, all-alpha NTP-PPase family	175
646450983	110	59.79	12	108	7	103	3.0e-28	116	COG2973	Trp operon repressor	103
646450984	643	29.19	344	634	1	295	3.0e-33	136	COG0741	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)	296
646450985	554	47.05	3	536	1	529	0.0e+00	570	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646450986	568	38.62	173	525	31	408	4.0e-44	173	COG0840	Methyl-accepting chemotaxis protein	408
646450987	298	33.56	5	288	3	289	3.0e-34	138	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450988	333	30.24	4	332	2	325	2.0e-60	226	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646450989	410	44.11	8	335	1	323	1.0e-91	330	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
646450990	220	53.98	1	218	1	226	2.0e-76	278	COG0120	Ribose 5-phosphate isomerase	227
646450991	297	26.67	4	296	1	297	1.0e-22	100	COG0583	DNA-binding transcriptional regulator, LysR family	297
646450992	240	42.56	1	238	4	243	1.0e-59	222	COG2968	Uncharacterized conserved protein YggE, contains kinase-interacting SIMPL domain	243
646450993	273	40.73	20	267	1	245	2.0e-60	225	COG1414	DNA-binding transcriptional regulator, IclR family	246
646450994	293	37.01	13	284	24	304	3.0e-42	165	COG0668	Small-conductance mechanosensitive channel	316
646450995	358	34.8	17	356	5	284	7.0e-89	320	COG0191	Fructose/tagatose bisphosphate aldolase	286
646450996	387	57.39	1	386	2	395	0.0e+00	498	COG0126	3-phosphoglycerate kinase	395
646450997	338	49.85	2	335	1	331	5.0e-115	408	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	335
646450998	664	67.92	1	664	3	663	0.0e+00	1075	COG0021	Transketolase	663
646450999	397	17.03	9	395	21	422	8.0e-13	68.7	COG0738	Fucose permease	422
646451000	658	69.59	10	658	5	652	0.0e+00	1033	COG1166	Arginine decarboxylase (spermidine biosynthesis)	652
646451002	384	71.83	1	383	2	388	0.0e+00	701	COG0192	S-adenosylmethionine synthetase	388
646451003	170	48.37	12	164	1	152	3.0e-45	174	COG3091	Predicted Zn-dependent metalloprotease, SprT family	156
646451004	232	69.23	1	231	1	234	1.0e-92	332	COG2356	Endonuclease I	237
646451005	244	45.97	1	242	1	246	1.0e-71	262	COG1385	16S rRNA U1498 N3-methylase RsmE	246
646451006	317	43.69	3	315	2	316	4.0e-78	284	COG0189	Glutathione synthase/RimK-type ligase, ATP-grasp superfamily	318
646451007	187	52.13	1	187	11	194	2.0e-65	242	COG1678	Putative transcriptional regulator, AlgH/UPF0301 family	194
646451008	143	46.38	3	139	1	138	3.0e-44	170	COG0816	RNase H-fold protein, predicted Holliday junction resolvase in Firmicutes and mycoplasms, involved in anti-termination at Rho-dependent terminators	141
646451009	334	66.57	1	332	1	326	0.0e+00	499	COG0158	Fructose-1,6-bisphosphatase	326
646451010	460	42.17	2	449	9	457	0.0e+00	527	COG0773	UDP-N-acetylmuramate-alanine ligase	459
646451011	432	65.35	2	430	1	429	0.0e+00	668	COG0104	Adenylosuccinate synthase	430
646451012	66	64.52	1	62	1	62	4.0e-14	69.5	COG3242	Uncharacterized conserved protein YjeT, DUF2065 family	62
646451013	331	27.93	1	326	2	288	1.0e-41	164	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
646451014	419	34.71	74	355	2	289	2.0e-53	203	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
646451015	433	53.12	6	421	1	409	0.0e+00	467	COG2262	50S ribosomal subunit-associated GTPase HflX	411
646451016	99	71.43	1	76	1	77	1.0e-25	107	COG1923	sRNA-binding regulator protein Hfq	77
646451017	313	52.13	10	311	3	305	5.0e-104	371	COG0324	tRNA A37 N6-isopentenylltransferase MiaA	308
646451018	645	40.22	2	645	3	637	0.0e+00	601	COG0323	DNA mismatch repair ATPase MutL	638
646451019	563	36.05	144	401	13	231	6.0e-53	202	COG0860	N-acetylmuramoyl-L-alanine amidase	231
646451020	160	54.36	4	151	1	149	5.0e-47	180	COG0802	tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE	149
646451021	513	48.38	236	505	10	284	2.0e-69	256	COG0063	NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain	284
646451023	379	56.47	10	347	2	337	9.0e-117	413	COG1600	Epoxyqueuosine reductase  QueG (queuosine biosynthesis)	337
646451025	308	32.61	1	308	3	324	4.0e-56	211	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
646451028	330	25.62	16	325	8	329	3.0e-32	132	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
646451029	458	26.03	42	426	10	336	2.0e-46	180	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
646451030	306	25.1	47	300	20	275	4.0e-23	102	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646451031	315	27.2	62	295	34	264	2.0e-26	113	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646451033	316	38.46	55	288	6	221	3.0e-42	165	COG0765	ABC-type amino acid transport system, permease component	222
646451034	272	58.23	24	272	3	240	6.0e-103	367	COG1126	ABC-type polar amino acid transport system, ATPase component	240
646451035	336	38.16	40	336	15	312	6.0e-53	201	COG0657	Acetyl esterase/lipase	312
646451036	141	53.15	1	141	1	143	3.0e-41	160	COG1764	Organic hydroperoxide reductase OsmC/OhrA	143
646451037	156	45.83	28	123	1	96	7.0e-13	66.9	COG1846	DNA-binding transcriptional regulator, MarR family	126
646451038	554	36.87	164	515	32	408	1.0e-47	184	COG0840	Methyl-accepting chemotaxis protein	408
646451039	530	35.41	191	518	56	408	4.0e-41	163	COG0840	Methyl-accepting chemotaxis protein	408
646451041	502	19.72	55	475	44	454	3.0e-16	80.2	COG1538	Outer membrane protein TolC	457
646451043	304	30.41	32	174	2	135	2.0e-13	70	COG4675	Microcystin-dependent protein  (function unknown)	170
646451045	439	19.26	150	425	9	302	4.0e-09	56.7	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646451048	180	76.67	1	180	2	181	6.0e-88	316	COG1949	Oligoribonuclease (3'-5' exoribonuclease)	184
646451049	349	39.37	30	344	3	301	3.0e-101	361	COG1162	Putative ribosome biogenesis GTPase RsgA	301
646451050	307	32.97	9	280	2	237	5.0e-55	208	COG0688	Phosphatidylserine decarboxylase	239
646451051	1108	36.05	195	1088	1	810	0.0e+00	637	COG3264	Small-conductance mechanosensitive channel	835
646451052	325	71.69	1	325	1	322	0.0e+00	496	COG2269	Elongation factor P--beta-lysine ligase (EF-P beta-lysylation pathway)	322
646451053	598	53.71	1	572	2	562	0.0e+00	646	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	562
646451054	245	47.88	5	240	1	234	2.0e-87	315	COG0479	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit	234
646451055	131	60.16	3	130	2	129	1.0e-43	168	COG3029	Fumarate reductase subunit C	129
646451056	118	72.03	1	118	1	118	2.0e-39	154	COG3080	Fumarate reductase subunit D	118
646451057	179	47.95	1	171	1	169	3.0e-52	198	COG3040	Bacterial lipocalin	174
646451058	117	60.71	1	112	5	115	6.0e-35	139	COG3169	Uncharacterized conserved protein, DUF486 family	116
646451059	188	47.33	1	131	1	131	2.0e-41	161	COG0231	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)	131
646451060	345	53.49	2	341	1	343	1.0e-126	446	COG1509	L-lysine 2,3-aminomutase (EF-P beta-lysylation pathway)	369
646451062	549	54.47	49	538	4	446	0.0e+00	568	COG0166	Glucose-6-phosphate isomerase	446
646451063	454	38.05	8	454	2	446	2.0e-120	426	COG0527	Aspartokinase	447
646451064	548	46.14	1	531	4	530	0.0e+00	480	COG1283	Na+/phosphate symporter	533
646451065	484	35.16	11	483	5	461	2.0e-59	223	COG0471	Di- and tricarboxylate transporter	461
646451066	1227	64.32	328	1192	1	842	0.0e+00	1229	COG1410	Methionine synthase I, cobalamin-binding domain	842
646451067	276	41.94	28	274	1	246	3.0e-62	232	COG1414	DNA-binding transcriptional regulator, IclR family	246
646451068	585	75.83	1	575	1	575	0.0e+00	933	COG4579	Isocitrate dehydrogenase kinase/phosphatase	578
646451069	435	73.79	1	435	1	433	0.0e+00	669	COG2224	Isocitrate lyase	433
646451070	532	48.79	3	531	8	541	0.0e+00	645	COG2225	Malate synthase	545
646451071	309	67.75	1	306	1	307	0.0e+00	501	COG1897	Homoserine trans-succinylase	307
646451076	181	49.13	4	176	3	168	2.0e-56	211	COG0663	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily	176
646451078	275	40.86	4	275	6	283	6.0e-79	287	COG0169	Shikimate 5-dehydrogenase	283
646451079	189	42.19	2	189	9	197	6.0e-49	186	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
646451080	183	38.89	54	177	11	136	2.0e-22	98.7	COG0551	ssDNA-binding Zn-finger and Zn-ribbon domains of topoisomerase 1	140
646451081	157	74.52	1	157	1	157	1.0e-56	212	COG2922	Uncharacterized conserved protein Smg, DUF494 family	157
646451082	377	41.35	1	365	1	350	1.0e-96	346	COG0758	Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake	350
646451083	169	54.17	1	164	1	168	5.0e-57	213	COG0242	Peptide deformylase	168
646451084	313	54.64	2	303	1	302	6.0e-121	427	COG0223	Methionyl-tRNA formyltransferase	307
646451085	431	41.97	93	430	1	355	5.0e-97	348	COG0144	16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family	355
646451086	460	35.78	3	232	1	225	9.0e-48	184	COG0569	Trk K+ transport system, NAD-binding component	225
646451087	141	60	1	133	1	130	3.0e-43	167	COG1970	Large-conductance mechanosensitive channel	130
646451088	74	65.62	4	67	5	66	2.0e-15	73.9	COG3036	Stalled ribosome alternative rescue factor ArfA	66
646451090	130	73.28	1	116	1	116	8.0e-47	179	COG0203	Ribosomal protein L17	116
646451091	329	59.43	8	323	1	313	1.0e-98	353	COG0202	DNA-directed RNA polymerase, alpha subunit/40 kD subunit	317
646451092	206	63.46	1	206	1	205	5.0e-60	224	COG0522	Ribosomal protein S4 or related protein	205
646451093	129	71.32	1	129	1	129	2.0e-49	187	COG0100	Ribosomal protein S11	129
646451094	118	65.55	1	118	1	119	6.0e-41	159	COG0099	Ribosomal protein S13	121
646451096	443	53.99	1	434	1	432	7.0e-130	457	COG0201	Preprotein translocase subunit SecY	436
646451097	144	54.67	1	144	1	150	4.0e-33	133	COG0200	Ribosomal protein L15	152
646451098	59	60	5	59	1	55	9.0e-15	71.7	COG1841	Ribosomal protein L30/L7E	55
646451099	166	62.8	4	166	17	180	6.0e-59	220	COG0098	Ribosomal protein S5	181
646451100	117	50.83	1	117	6	125	2.0e-29	120	COG0256	Ribosomal protein L18	125
646451101	177	55.93	1	176	1	176	8.0e-60	223	COG0097	Ribosomal protein L6P/L9E	178
646451102	130	58.78	1	129	1	131	1.0e-46	178	COG0096	Ribosomal protein S8	132
646451103	101	63.93	41	101	1	61	9.0e-18	81.8	COG0199	Ribosomal protein S14	61
646451104	179	67.6	1	179	1	179	2.0e-80	291	COG0094	Ribosomal protein L5	180
646451105	104	55.24	1	103	1	103	2.0e-18	83.8	COG0198	Ribosomal protein L24	104
646451106	123	75.61	1	123	1	122	2.0e-49	187	COG0093	Ribosomal protein L14	122
646451107	84	54.88	1	82	4	85	4.0e-25	106	COG0186	Ribosomal protein S17	87
646451108	63	56.45	2	63	4	65	1.0e-08	51.4	COG0255	Ribosomal protein L29	69
646451109	136	63.24	1	133	2	137	3.0e-47	180	COG0197	Ribosomal protein L16/L10AE	146
646451110	233	63.68	12	233	1	223	8.0e-80	289	COG0092	Ribosomal protein S3	233
646451111	110	67.27	1	110	9	118	4.0e-35	139	COG0091	Ribosomal protein L22	120
646451112	92	71.74	1	92	1	92	1.0e-37	148	COG0185	Ribosomal protein S19	93
646451113	273	68.36	1	273	1	275	6.0e-113	400	COG0090	Ribosomal protein L2	275
646451114	100	60.64	7	99	1	94	7.0e-23	98.7	COG0089	Ribosomal protein L23	94
646451115	201	47.62	1	201	2	211	2.0e-55	208	COG0088	Ribosomal protein L4	214
646451116	209	63.68	1	209	1	212	1.0e-77	282	COG0087	Ribosomal protein L3	218
646451117	103	74.51	1	102	1	102	1.0e-38	151	COG0051	Ribosomal protein S10	104
646451118	157	70.06	1	157	1	157	3.0e-57	214	COG2193	Bacterioferritin (cytochrome b1)	157
646451119	64	48.44	1	64	1	63	1.0e-11	61.9	COG2906	Bacterioferritin-associated ferredoxin	63
646451120	394	87.31	1	394	1	394	0.0e+00	733	COG0050	Translation elongation factor EF-Tu, a GTPase	394
646451121	704	67.56	1	704	1	693	0.0e+00	1019	COG0480	Translation elongation factor EF-G, a GTPase	697
646451122	156	61.49	2	149	1	148	2.0e-53	201	COG0049	Ribosomal protein S7	148
646451123	124	76.42	1	123	7	129	6.0e-50	189	COG0048	Ribosomal protein S12	129
646451124	95	57.29	1	95	1	96	1.0e-22	98	COG2168	Sulfur transfer complex TusBCD TusB component, DsrH family	96
646451125	119	61.34	1	119	1	118	2.0e-41	160	COG2923	Sulfur relay (sulfurtransferase) complex TusC component, DsrF/TusC family	118
646451126	129	50	2	129	1	126	3.0e-38	150	COG1553	Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family	126
646451127	240	63.18	19	235	1	220	4.0e-79	287	COG2964	Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains	220
646451128	565	42.57	22	562	2	545	0.0e+00	517	COG2194	Phosphoethanolamine transferase for periplasmic glucans (OPG), alkaline phosphatase superfamily	555
646451129	222	40	1	220	1	229	5.0e-54	204	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646451130	376	26.43	36	363	2	329	1.0e-28	120	COG0642	Signal transduction histidine kinase	336
646451131	285	54.5	50	259	1	205	4.0e-55	208	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	205
646451132	73	58.33	2	73	1	72	1.0e-12	64.6	COG2900	Uncharacterized coiled-coil protein SlyX (sensitive to lysis X)	72
646451133	346	33.61	226	346	1	121	6.0e-19	88.4	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646451134	338	27.81	2	334	1	322	6.0e-44	171	COG2334	Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist	331
646451135	460	26.27	1	444	1	446	2.0e-26	114	COG0531	Amino acid transporter	466
646451136	201	52.3	1	171	1	174	3.0e-48	184	COG1047	FKBP-type peptidyl-prolyl cis-trans isomerase 2	174
646451137	64	49.21	2	64	4	66	5.0e-12	62.7	COG3529	Predicted nucleic-acid-binding protein, contains Zn-ribbon domain	66
646451138	604	45.14	1	393	2	397	2.0e-73	270	COG0475	Kef-type K+ transport system, membrane component KefB	397
646451139	183	35.45	6	179	2	189	2.0e-40	158	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	189
646451140	639	46.31	1	519	3	527	0.0e+00	546	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646451141	201	34.72	4	191	3	195	3.0e-19	88.4	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
646451142	351	57.19	30	350	19	344	5.0e-109	388	COG0429	Predicted hydrolase of the alpha/beta-hydrolase fold	345
646451143	78	80	1	70	1	70	7.0e-24	101	COG3089	Uncharacterized conserved protein YheU, UPF0270 family	72
646451144	289	86.11	1	288	1	288	0.0e+00	518	COG3954	Phosphoribulokinase	289
646451145	135	54.01	1	133	2	137	2.0e-32	130	COG1765	Uncharacterized OsmC-related protein	137
646451146	210	36.95	9	210	13	214	2.0e-40	158	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
646451147	413	55.77	7	412	1	402	0.0e+00	569	COG4992	Acetylornithine/succinyldiaminopimelate/putrescine aminotransferase	404
646451148	191	63.87	1	191	3	190	2.0e-85	308	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
646451149	87	30.56	1	72	1	68	5.0e-06	42.9	COG1476	DNA-binding transcriptional regulator, XRE-family HTH domain	68
646451150	88	72.46	2	70	3	71	1.0e-22	98.2	COG3423	Predicted transcriptional regulator, lambda repressor-like DNA-binding domain	82
646451151	681	41.69	1	312	1	314	3.0e-68	253	COG4643	Uncharacterized domain associated with phage/plasmid primase	366
646451153	67	57.14	1	63	7	69	3.0e-15	73.4	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
646451157	333	22.27	30	272	1	229	5.0e-19	88.8	COG0338	Site-specific DNA-adenine methylase	274
646451158	395	23.15	83	391	4	308	5.0e-11	62.7	COG0582	Integrase	309
646451159	401	34.21	280	393	12	124	2.0e-17	83.8	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646451163	208	47.78	2	204	1	201	1.0e-52	199	COG3179	Predicted chitinase	206
646451164	380	23.2	60	365	67	377	4.0e-07	49.4	COG2807	Cyanate permease	395
646451172	190	47.85	29	189	1	158	2.0e-50	192	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
646451173	384	30.23	1	382	1	369	8.0e-59	221	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646451175	334	53.14	1	312	3	314	1.0e-115	409	COG0180	Tryptophanyl-tRNA synthetase	314
646451176	232	46.33	4	221	1	216	4.0e-49	188	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
646451177	225	59.91	1	222	1	220	3.0e-88	318	COG0036	Pentose-5-phosphate-3-epimerase	220
646451178	274	51.47	3	270	1	271	4.0e-78	284	COG0338	Site-specific DNA-adenine methylase	274
646451179	357	38.08	39	355	9	291	2.0e-35	143	COG3266	Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain	292
646451180	361	59.56	1	361	1	359	0.0e+00	510	COG0337	3-dehydroquinate synthetase	360
646451181	189	54.71	20	189	2	169	7.0e-55	206	COG0703	Shikimate kinase	172
646451185	186	21.79	1	179	4	182	1.0e-09	56.5	COG3166	Tfp pilus assembly protein PilN	206
646451187	852	52.43	1	852	2	797	0.0e+00	1047	COG5009	Membrane carboxypeptidase/penicillin-binding protein	797
646451189	184	20.38	36	177	1	155	6.0e-06	44.2	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
646451191	234	23.48	7	224	1	227	3.0e-22	98.8	COG1011	FMN phosphatase YigB, HAD superfamily	229
646451192	137	58.95	9	103	5	99	6.0e-25	106	COG1188	Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain	100
646451193	290	49.3	1	280	1	286	5.0e-99	354	COG1281	Redox-regulated molecular chaperone, HSP33 family	286
646451194	539	64.8	7	539	6	529	0.0e+00	834	COG1866	Phosphoenolpyruvate carboxykinase, ATP-dependent	529
646451195	470	31.33	142	443	22	334	5.0e-37	149	COG0642	Signal transduction histidine kinase	336
646451196	239	43.35	5	236	1	229	4.0e-63	234	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646451197	160	42.38	6	155	1	150	5.0e-36	143	COG0782	Transcription elongation factor, GreA/GreB family	151
646451198	673	18.71	9	624	2	592	9.0e-35	142	COG1368	Phosphoglycerol transferase MdoB or a related enzyme of AlkP superfamily	650
646451200	779	61.83	1	779	6	780	0.0e+00	1065	COG2183	Transcriptional accessory protein Tex/SPT6	780
646451203	160	39.26	1	159	1	159	2.0e-38	151	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
646451204	259	25.65	3	253	11	279	2.0e-22	99.8	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646451205	239	41.38	8	239	14	225	2.0e-47	182	COG1040	Predicted amidophosphoribosyltransferases	225
646451206	191	51.61	98	189	1	93	1.0e-27	116	COG0694	Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain	93
646451207	717	40.04	128	686	1	516	0.0e+00	487	COG1640	4-alpha-glucanotransferase	520
646451208	805	45.07	6	801	5	746	0.0e+00	777	COG0058	Glucan phosphorylase	750
646451209	260	41.43	10	260	2	252	9.0e-75	273	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646451210	274	31.13	82	274	4	215	5.0e-23	101	COG0705	Membrane associated serine protease, rhomboid family	228
646451211	403	36.83	101	403	1	310	5.0e-53	201	COG0524	Sugar or nucleoside kinase, ribokinase family	311
646451212	306	27.17	1	274	2	272	4.0e-45	175	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646451213	159	38.46	1	156	1	154	1.0e-36	146	COG2731	Beta-galactosidase, beta subunit	154
646451214	431	25.12	21	424	25	433	2.0e-33	136	COG2271	Sugar phosphate permease	448
646451215	106	30.3	1	95	1	99	2.0e-15	73.8	COG0607	Rhodanese-related sulfurtransferase	110
646451216	499	49.41	1	498	10	518	0.0e+00	577	COG0578	Glycerol-3-phosphate dehydrogenase	532
646451217	815	51.3	9	812	1	750	0.0e+00	934	COG0058	Glucan phosphorylase	750
646451218	477	53.29	1	476	1	478	0.0e+00	539	COG0297	Glycogen synthase	487
646451219	428	53.75	15	427	1	390	0.0e+00	544	COG0448	ADP-glucose pyrophosphorylase	393
646451220	656	50	1	656	9	692	0.0e+00	755	COG1523	Pullulanase/glycogen debranching enzyme	697
646451221	727	60.38	100	723	1	626	0.0e+00	813	COG0296	1,4-alpha-glucan branching enzyme	628
646451222	561	58.68	4	560	1	553	0.0e+00	702	COG3275	Sensor histidine kinase, LytS/YehU family	557
646451223	70	67.69	4	68	1	65	2.0e-24	103	COG1278	Cold shock protein, CspA family	67
646451224	139	38.35	1	133	4	136	1.0e-28	118	COG0864	Metal-responsive transcriptional regulator, contains CopG/Arc/MetJ DNA-binding domain	136
646451225	366	33.15	1	366	1	334	5.0e-99	354	COG0136	Aspartate-semialdehyde dehydrogenase	334
646451226	197	44.44	1	196	4	201	1.0e-35	143	COG2095	Small neutral amino acid transporter SnatA, MarC family	203
646451227	438	54.65	1	438	2	442	5.0e-103	368	COG2610	H+/gluconate symporter or related permease	442
646451229	172	61.49	9	169	1	160	1.0e-64	239	COG3265	Gluconate kinase	161
646451230	332	35.26	7	332	1	329	7.0e-74	271	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646451232	232	41.22	1	230	1	244	6.0e-58	217	COG1741	Redox-sensitive bicupin YhaK, pirin superfamily	276
646451233	400	31.37	2	398	1	385	8.0e-66	244	COG0247	Fe-S oxidoreductase	388
646451234	416	50.24	1	414	1	416	2.0e-123	436	COG3075	Anaerobic glycerol-3-phosphate dehydrogenase	421
646451235	547	39.11	9	528	12	532	0.0e+00	476	COG0578	Glycerol-3-phosphate dehydrogenase	532
646451236	449	53.33	1	447	1	446	0.0e+00	538	COG2271	Sugar phosphate permease	448
646451237	362	39.14	26	352	5	257	3.0e-47	182	COG0584	Glycerophosphoryl diester phosphodiesterase	257
646451238	269	34.81	1	267	2	264	4.0e-56	211	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
646451239	330	32.9	22	329	1	294	3.0e-54	206	COG2267	Lysophospholipase, alpha-beta hydrolase superfamily	298
646451240	206	38.65	1	204	1	207	2.0e-33	135	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
646451241	208	34.12	1	208	2	207	1.0e-26	113	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
646451242	614	59.09	18	608	5	587	0.0e+00	777	COG0514	Superfamily II DNA helicase RecQ	590
646451243	289	59.26	10	289	21	317	2.0e-98	352	COG2829	Outer membrane phospholipase A	317
646451244	156	27.54	19	155	14	136	2.0e-14	71.6	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
646451245	308	61.25	8	296	6	293	7.0e-88	317	COG2962	Uncharacterized membrane protein RarD, contains two EamA domains	293
646451246	352	47.85	1	347	2	350	6.0e-63	234	COG3180	Uncharacterized membrane protein AbrB, regulator of aidB expression	352
646451247	316	36.53	1	316	4	322	3.0e-67	249	COG0598	Mg2+ and Co2+ transporter CorA	322
646451248	720	46.52	8	653	1	655	0.0e+00	622	COG0210	Superfamily I DNA or RNA helicase	655
646451249	238	25.11	9	238	3	226	5.0e-26	111	COG1011	FMN phosphatase YigB, HAD superfamily	229
646451250	302	72.54	6	300	5	299	5.0e-128	450	COG4973	Site-specific recombinase XerC	299
646451251	233	57.66	12	231	3	218	2.0e-55	209	COG3159	Uncharacterized conserved protein YigA, DUF484 family	218
646451252	274	55.47	1	274	1	272	3.0e-104	371	COG0253	Diaminopimelate epimerase	272
646451253	61	40.38	7	58	1	52	4.0e-06	43.1	COG5567	Predicted small periplasmic lipoprotein YifL (function unknown0	58
646451254	106	60.95	1	105	1	105	6.0e-39	152	COG1965	Iron-binding protein CyaY, frataxin homolog	106
646451255	852	77.01	1	850	1	853	0.0e+00	1320	COG3072	Adenylate cyclase	853
646451256	312	64.03	6	307	4	306	9.0e-122	430	COG0181	Porphobilinogen deaminase	307
646451257	246	33.2	1	246	2	246	7.0e-45	174	COG1587	Uroporphyrinogen-III synthase	248
646451258	375	53.23	1	370	1	368	1.0e-87	316	COG2959	Uncharacterized conserved protein HemX (no evidence of involvement in heme biosynthesis)	391
646451259	398	58.23	1	395	1	395	3.0e-119	422	COG3071	Uncharacterized conserved protein HemY, contains two TPR repeats	400
646451260	386	43.57	10	380	10	390	3.0e-105	375	COG1473	Metal-dependent amidase/aminoacylase/carboxypeptidase	392
646451261	253	58.26	1	242	2	239	2.0e-96	345	COG1126	ABC-type polar amino acid transport system, ATPase component	240
646451262	227	44.76	16	225	15	222	6.0e-50	190	COG0765	ABC-type amino acid transport system, permease component	222
646451263	259	31.84	3	255	2	267	2.0e-34	139	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646451265	454	41.71	15	445	5	438	6.0e-121	428	COG0015	Adenylosuccinate lyase	438
646451266	112	34.62	6	108	8	109	3.0e-14	70.4	COG4538	Uncharacterized protein	112
646451267	357	29.44	4	353	5	354	2.0e-46	180	COG0371	Glycerol dehydrogenase or related enzyme, iron-containing ADH family	360
646451268	269	28.68	9	262	5	268	2.0e-33	136	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646451273	464	51.43	2	456	3	455	0.0e+00	517	COG1113	L-asparagine transporter and related permeases	462
646451274	244	42.11	1	244	4	249	4.0e-64	238	COG1922	UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family	253
646451277	416	23.56	1	414	6	414	3.0e-10	60.1	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
646451278	376	45.24	1	376	5	372	1.0e-111	396	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
646451280	419	48	5	419	11	424	0.0e+00	510	COG0677	UDP-N-acetyl-D-mannosaminuronate dehydrogenase	436
646451281	376	56.38	1	373	4	372	0.0e+00	483	COG0381	UDP-N-acetylglucosamine 2-epimerase	383
646451282	344	38.53	6	342	9	342	5.0e-73	268	COG3765	LPS O-antigen chain length determinant protein, WzzB/FepE family	347
646451283	357	27.53	1	307	4	310	2.0e-37	150	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
646451284	419	79.24	1	419	4	421	0.0e+00	733	COG1158	Transcription termination factor Rho	422
646451286	428	40.88	1	428	21	446	3.0e-111	395	COG0513	Superfamily II DNA and RNA helicase	513
646451287	498	41.43	7	487	4	492	1.0e-127	450	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	492
646451288	604	28.31	40	521	3	434	3.0e-58	220	COG5434	Polygalacturonase	542
646451289	674	47.66	1	650	1	655	0.0e+00	609	COG0210	Superfamily I DNA or RNA helicase	655
646451291	1325	47.99	105	527	1	391	7.0e-122	432	COG0506	Proline dehydrogenase	391
646451291	1325	66.58	530	1325	1	769	0.0e+00	1039	COG4230	Delta 1-pyrroline-5-carboxylate dehydrogenase	769
646451292	499	47.28	4	484	1	493	2.0e-96	346	COG0591	Na+/proline symporter	493
646451294	492	41.62	19	362	1	338	2.0e-124	439	COG0059	Ketol-acid reductoisomerase	338
646451295	295	34.24	1	294	1	289	1.0e-38	153	COG0583	DNA-binding transcriptional regulator, LysR family	297
646451296	254	29.86	9	146	2	133	4.0e-13	68.5	COG4461	Uncharacterized protein YPO0702	185
646451297	246	22.27	5	225	4	226	9.0e-17	80.8	COG5587	Uncharacterized conserved protein, DUF2461 family	228
646451298	514	52.3	9	351	1	347	9.0e-120	424	COG1171	Threonine dehydratase	347
646451299	616	55.27	1	614	8	575	0.0e+00	795	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
646451300	308	44.9	5	296	1	284	2.0e-77	282	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
646451301	85	61.63	1	85	1	86	5.0e-22	96.2	COG3978	Acetolactate synthase small subunit, contains ACT domain	86
646451302	548	51.45	1	543	2	549	0.0e+00	639	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
646451303	407	24.68	5	390	4	389	2.0e-24	107	COG2814	Predicted arabinose efflux permease, MFS family	394
646451304	508	60.9	15	499	1	490	0.0e+00	626	COG0606	Predicted ATPase with chaperone activity	490
646451305	112	81.25	1	112	1	112	2.0e-42	164	COG3085	Uncharacterized conserved protein YifE, UPF0438 family	112
646451306	275	29.02	1	267	1	284	7.0e-29	121	COG0583	DNA-binding transcriptional regulator, LysR family	297
646451314	290	43.82	23	286	5	268	2.0e-82	299	COG0796	Glutamate racemase	269
646451315	621	52.97	4	621	2	608	0.0e+00	655	COG4206	Outer membrane cobalamin receptor protein	608
646451316	367	32.26	1	359	75	432	1.0e-82	300	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
646451318	216	24.62	7	200	3	196	8.0e-07	47.3	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646451319	468	39.04	8	460	4	454	0.0e+00	464	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
646451320	305	33.55	1	299	1	297	3.0e-42	165	COG0583	DNA-binding transcriptional regulator, LysR family	297
646451321	243	67.66	2	163	1	165	3.0e-69	255	COG0678	Peroxiredoxin	165
646451322	298	49.48	11	294	3	291	5.0e-86	311	COG0685	5,10-methylenetetrahydrofolate reductase	291
646451323	811	33.56	13	454	3	445	1.0e-100	361	COG0527	Aspartokinase	447
646451324	386	49.1	6	384	9	396	0.0e+00	463	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
646451325	105	92.38	1	105	1	105	2.0e-52	196	COG3060	Transcriptional regulator of met regulon	105
646451326	71	58.11	1	71	1	74	5.0e-22	96.1	COG0254	Ribosomal protein L31	75
646451327	740	50.48	9	739	1	729	0.0e+00	885	COG1198	Primosomal protein N' (replication factor Y) - superfamily II helicase	730
646451328	356	43.54	10	341	1	333	5.0e-90	324	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646451329	323	39.23	15	323	2	264	6.0e-42	164	COG3087	Cell division protein FtsN	264
646451330	176	75.43	1	175	4	178	2.0e-76	277	COG5405	ATP-dependent protease HslVU (ClpYQ), peptidase subunit	178
646451331	443	76.13	1	443	1	444	0.0e+00	725	COG1220	ATP-dependent protease HslVU (ClpYQ), ATPase subunit	444
646451332	305	47.33	7	305	5	300	2.0e-73	269	COG1575	1,4-dihydroxy-2-naphthoate octaprenyltransferase	303
646451333	161	47.24	4	161	12	174	3.0e-45	174	COG0684	Regulator of RNase E activity RraA	210
646451334	80	81.01	1	79	1	79	3.0e-13	67	COG3074	Cell division protein ZapB, interacts with FtsZ	79
646451335	283	50.78	7	259	2	241	3.0e-57	215	COG0580	Glycerol uptake facilitator and related aquaporins (Major Intrinsic Protein Family)	241
646451336	503	69.14	3	501	2	499	0.0e+00	838	COG0554	Glycerol kinase	499
646451337	336	67.37	1	331	1	330	0.0e+00	486	COG1494	Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase or related protein	332
646451338	248	32.46	1	248	2	266	1.0e-48	186	COG1018	Ferredoxin-NADP reductase	266
646451339	141	33.09	1	131	5	117	9.0e-16	76.1	COG3152	Uncharacterized membrane protein YhaH, DUF805 family	125
646451341	256	57.87	1	253	1	251	7.0e-84	303	COG0149	Triosephosphate isomerase	251
646451342	472	41.7	17	472	11	480	5.0e-114	405	COG1785	Alkaline phosphatase	482
646451345	180	49.71	7	180	34	205	6.0e-58	216	COG1859	RNA:NAD 2'-phosphotransferase, TPT1/KptA family	211
646451360	85	72.31	2	66	5	69	3.0e-22	96.6	COG3423	Predicted transcriptional regulator, lambda repressor-like DNA-binding domain	82
646451369	2850	16.98	910	1707	24	783	2.0e-06	50.1	COG3210	Large exoprotein involved in heme utilization or adhesion	1013
646451370	178	44.74	1	151	1	147	9.0e-36	143	COG2994	ACP:hemolysin acyltransferase (hemolysin-activating protein)	148
646451371	576	41.81	18	576	1	554	0.0e+00	503	COG2831	Hemolysin activation/secretion protein	554
646451372	365	49.44	5	362	8	345	1.0e-125	443	COG2957	Agmatine/peptidylarginine deiminase	346
646451373	294	34.15	3	284	2	269	9.0e-56	210	COG0388	Predicted amidohydrolase	274
646451374	320	55.13	1	320	1	341	1.0e-113	403	COG0205	6-phosphofructokinase	347
646451375	300	40.88	1	295	3	298	4.0e-77	281	COG0053	Divalent metal cation (Fe/Co/Zn/Cd) transporter	304
646451388	232	43.53	3	232	2	229	2.0e-59	222	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646451389	456	35.62	156	455	33	331	3.0e-38	153	COG0642	Signal transduction histidine kinase	336
646451393	193	28.28	12	154	6	150	8.0e-14	70.4	COG3226	DNA-binding transcriptional regulator YbjK	204
646451394	369	23.37	62	309	1	258	5.0e-22	99	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
646451395	154	56.86	1	152	2	153	1.0e-59	221	COG0219	tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain	155
646451397	318	31.29	7	315	1	308	1.0e-36	147	COG0679	Predicted permease	311
646451398	247	35.71	7	247	5	255	2.0e-46	179	COG0584	Glycerophosphoryl diester phosphodiesterase	257
646451399	358	52.71	1	351	1	338	4.0e-128	451	COG3839	ABC-type sugar transport system, ATPase component	338
646451400	292	37.94	10	288	2	276	8.0e-56	210	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
646451401	295	45.17	4	291	2	290	4.0e-57	215	COG1175	ABC-type sugar transport system, permease component	295
646451402	439	27.55	10	434	14	433	4.0e-48	186	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
646451403	253	44.88	1	253	1	253	7.0e-66	244	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646451404	311	41.4	11	294	3	285	6.0e-71	260	COG2084	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase	286
646451405	425	48.43	5	417	4	409	2.0e-118	419	COG3395	Uncharacterized conserved protein YgbK, DUF1537 family	413
646451406	219	36.67	14	218	4	208	5.0e-42	164	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
646451407	260	56.81	1	257	1	257	1.0e-104	372	COG3622	Hydroxypyruvate isomerase	260
646451408	457	39.17	4	457	1	442	2.0e-67	250	COG2610	H+/gluconate symporter or related permease	442
646451409	562	34.74	144	520	10	408	3.0e-44	173	COG0840	Methyl-accepting chemotaxis protein	408
646451410	566	34.47	132	517	1	408	2.0e-44	174	COG0840	Methyl-accepting chemotaxis protein	408
646451411	542	33.66	132	515	1	406	3.0e-42	166	COG0840	Methyl-accepting chemotaxis protein	408
646451412	543	33.9	132	515	1	406	3.0e-42	166	COG0840	Methyl-accepting chemotaxis protein	408
646451414	546	29.71	128	515	1	406	6.0e-37	148	COG0840	Methyl-accepting chemotaxis protein	408
646451415	304	31.58	1	303	1	297	4.0e-31	128	COG0583	DNA-binding transcriptional regulator, LysR family	297
646451416	431	19.68	7	424	20	440	3.0e-19	89.9	COG2271	Sugar phosphate permease	448
646451417	307	38.31	12	304	4	294	8.0e-81	294	COG1951	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain	297
646451418	202	49.73	1	180	1	177	5.0e-55	207	COG1838	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain	184
646451419	294	38.87	22	275	5	262	7.0e-61	227	COG0179	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	266
646451420	394	39.44	5	394	65	453	4.0e-91	328	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
646451421	233	62.13	1	233	3	237	2.0e-92	331	COG0410	ABC-type branched-chain amino acid transport system, ATPase component	237
646451422	256	61.26	3	255	1	250	8.0e-98	349	COG0411	ABC-type branched-chain amino acid transport system, ATPase component	250
646451423	426	51.06	87	409	4	309	2.0e-61	230	COG4177	ABC-type branched-chain amino acid transport system, permease component	314
646451424	308	48.03	5	307	3	297	3.0e-59	222	COG0559	Branched-chain amino acid ABC-type transport system, permease component	297
646451425	370	39.11	17	366	1	358	3.0e-71	262	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	366
646451427	285	39.01	9	285	62	333	5.0e-72	264	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
646451428	325	43.67	25	324	2	296	2.0e-76	279	COG2177	Cell division protein FtsX	297
646451429	222	67.57	1	222	1	222	6.0e-95	340	COG2884	ABC-type ATPase involved in cell division	223
646451430	466	60	147	463	16	340	2.0e-115	409	COG0552	Signal recognition particle GTPase	340
646451431	207	49.73	12	192	1	185	3.0e-60	224	COG0742	16S rRNA G966 N2-methylase RsmD	187
646451432	95	55.56	1	90	1	89	7.0e-19	85.3	COG3776	Uncharacterized conserved protein YhhL, DUF1145 family	91
646451433	108	49.09	1	107	1	108	5.0e-36	142	COG4517	Uncharacterized protein	109
646451434	209	42.86	1	208	2	211	4.0e-27	114	COG3714	Uncharacterized membrane protein YhhN	212
646451435	81	42.11	6	80	2	77	1.0e-20	91.1	COG0425	TusA-related sulfurtransferase	78
646451436	222	42.53	1	215	14	233	2.0e-41	162	COG1738	Uncharacterized PurR-regulated membrane protein YhhQ, DUF165 family	233
646451438	405	21.2	52	391	43	382	2.0e-07	50.6	COG2814	Predicted arabinose efflux permease, MFS family	394
646451439	321	29.9	22	310	1	284	8.0e-39	154	COG1295	Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase)	303
646451440	67	50.77	1	65	1	65	1.0e-17	81.1	COG1942	Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family	69
646451441	310	30.91	5	305	1	297	4.0e-48	185	COG0524	Sugar or nucleoside kinase, ribokinase family	311
646451442	497	20.83	22	447	6	411	2.0e-36	147	COG0612	Predicted Zn-dependent peptidase	438
646451443	428	52.67	2	408	1	404	2.0e-105	376	COG1301	Na+/H+-dicarboxylate symporter	415
646451448	696	24.49	90	523	16	425	4.0e-45	176	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
646451449	271	26.44	1	253	2	258	3.0e-23	102	COG1192	Cellulose biosynthesis protein BcsQ	259
646451452	471	30.44	3	469	2	459	1.0e-83	303	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
646451453	335	49.51	13	319	4	265	4.0e-102	364	COG4608	ABC-type oligopeptide transport system, ATPase component	309
646451454	326	54.09	3	317	1	315	1.0e-122	433	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
646451455	300	52.74	10	300	2	288	1.0e-79	289	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646451456	339	49.56	1	339	1	317	2.0e-97	349	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646451457	535	36.54	1	535	2	553	2.0e-104	373	COG0747	ABC-type transport system, periplasmic component	556
646451458	447	43.82	22	447	10	438	6.0e-111	394	COG3493	Na+/citrate or Na+/malate symporter	438
646451459	240	47.6	2	230	1	224	3.0e-68	251	COG4565	Response regulator of citrate/malate metabolism	224
646451460	537	43.9	1	530	1	532	0.0e+00	528	COG3290	Sensor histidine kinase regulating citrate/malate metabolism	537
646451461	470	36.11	7	468	4	460	2.0e-53	203	COG0471	Di- and tricarboxylate transporter	461
646451462	149	34.29	1	133	7	145	2.0e-24	105	COG0071	Molecular chaperone IbpA, HSP20 family	146
646451463	137	34.75	1	137	7	146	2.0e-27	114	COG0071	Molecular chaperone IbpA, HSP20 family	146
646451464	123	44.44	11	82	4	74	2.0e-14	71.5	COG5645	Uncharacterized conserved protein YceK	80
646451465	334	29.18	4	328	2	326	6.0e-52	197	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646451467	348	21.94	1	344	12	371	2.0e-66	246	COG4692	Predicted neuraminidase (sialidase)	381
646451468	319	26.64	13	284	4	272	2.0e-39	156	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646451470	528	43.73	6	522	5	529	0.0e+00	532	COG1069	Ribulose kinase	544
646451473	231	36.91	1	226	1	231	1.0e-40	159	COG2186	DNA-binding transcriptional regulator, FadR family	241
646451474	394	59.39	1	394	1	362	0.0e+00	534	COG1312	D-mannonate dehydratase	362
646451475	271	36.16	1	270	1	263	3.0e-54	205	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
646451476	668	37.4	333	667	48	408	2.0e-54	207	COG0840	Methyl-accepting chemotaxis protein	408
646451477	144	24.34	1	141	3	154	2.0e-11	61.9	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
646451480	400	56.3	1	394	1	404	0.0e+00	553	COG2081	Predicted flavoprotein YhiN	408
646451482	287	27.99	1	286	10	255	1.0e-31	130	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	259
646451483	367	49.13	1	344	1	338	3.0e-110	391	COG3839	ABC-type sugar transport system, ATPase component	338
646451484	348	34.3	107	347	51	281	2.0e-40	159	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
646451485	305	33.1	18	295	16	292	7.0e-35	141	COG1175	ABC-type sugar transport system, permease component	295
646451486	456	22.47	2	451	6	420	2.0e-56	214	COG2182	Maltose-binding periplasmic protein MalE	420
646451487	367	28.25	75	367	5	309	3.0e-33	136	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646451490	456	60.09	8	448	3	443	0.0e+00	642	COG3048	D-serine dehydratase	443
646451491	154	23.57	6	133	15	154	4.0e-13	67.7	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646451493	400	28.49	28	397	14	382	3.0e-18	86.8	COG2814	Predicted arabinose efflux permease, MFS family	394
646451494	296	30.48	7	293	6	292	7.0e-37	147	COG0583	DNA-binding transcriptional regulator, LysR family	297
646451495	393	19	1	372	4	381	1.0e-07	51	COG2814	Predicted arabinose efflux permease, MFS family	394
646451497	264	32.69	1	253	2	261	8.0e-40	157	COG0300	Short-chain dehydrogenase	265
646451500	561	27.67	26	560	1	581	8.0e-119	421	COG0272	NAD-dependent DNA ligase	667
646451501	207	59.47	1	190	1	187	5.0e-79	287	COG0194	Guanylate kinase	191
646451502	91	50	1	73	1	74	2.0e-12	64.2	COG1758	DNA-directed RNA polymerase, subunit K/omega	74
646451503	700	46.03	1	698	6	701	0.0e+00	923	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	701
646451505	693	57.12	10	686	11	677	0.0e+00	900	COG1200	RecG-like helicase	677
646451506	462	42.76	17	462	1	438	2.0e-104	373	COG2233	Xanthine/uracil permease	451
646451508	313	33.62	35	145	39	152	6.0e-08	51.8	COG2153	Predicted N-acyltransferase, GNAT family	155
646451509	145	61.38	1	145	1	145	1.0e-62	231	COG1490	D-Tyr-tRNAtyr deacylase	145
646451510	203	19.7	1	187	5	201	3.0e-17	81.9	COG1011	FMN phosphatase YigB, HAD superfamily	229
646451511	607	73.18	1	604	1	603	0.0e+00	1062	COG1217	Predicted membrane GTPase involved in stress response	603
646451512	469	51.89	1	469	1	443	0.0e+00	532	COG0174	Glutamine synthetase	443
646451514	349	62.92	1	349	1	356	0.0e+00	475	COG3852	Signal transduction histidine kinase, nitrogen specific	363
646451515	470	52.44	1	470	2	457	0.0e+00	568	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646451517	457	41.06	14	447	1	416	5.0e-123	434	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
646451519	177	50	1	169	1	167	9.0e-31	126	COG3078	Ribosome assembly protein YihI, activator of Der GTPase	169
646451520	214	58.08	6	202	3	200	2.0e-75	275	COG0218	GTP-binding protein EngB required for normal cell division	200
646451521	929	61.73	330	929	2	593	0.0e+00	828	COG0749	DNA polymerase I - 3'-5' exonuclease and polymerase domains	593
646451523	328	32.44	1	325	1	331	9.0e-61	227	COG2334	Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist	331
646451524	89	76.14	1	88	1	88	6.0e-38	148	COG3084	Uncharacterized protein YihD, DUF1040 family	88
646451525	196	46.39	1	193	4	191	6.0e-51	193	COG0746	Molybdopterin-guanine dinucleotide biosynthesis protein A	192
646451526	178	47.85	4	163	2	160	8.0e-39	153	COG1763	Molybdopterin-guanine dinucleotide biosynthesis protein	161
646451531	332	45.92	1	330	3	332	3.0e-99	355	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646451532	308	42.54	5	308	1	311	2.0e-58	219	COG0524	Sugar or nucleoside kinase, ribokinase family	311
646451533	296	42.86	3	296	10	310	8.0e-49	187	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646451534	322	55.13	10	318	1	307	2.0e-65	243	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646451535	501	56.65	1	493	5	499	0.0e+00	664	COG1129	ABC-type sugar transport system, ATPase component	500
646451536	139	63.31	1	139	1	135	3.0e-48	184	COG1869	D-ribose pyranose/furanose isomerase RbsD	135
646451537	622	63.02	1	622	7	627	0.0e+00	854	COG3158	K+ transporter	627
646451538	498	26.73	1	309	5	320	5.0e-46	179	COG0714	MoxR-like ATPase	329
646451539	491	35.38	17	485	2	434	1.0e-99	357	COG2425	Uncharacterized protein, contains a von Willebrand factor type A (vWA) domain	437
646451540	154	34.23	7	154	5	153	7.0e-31	126	COG1522	DNA-binding transcriptional regulator, Lrp family	154
646451541	147	26.14	1	146	1	151	1.0e-23	101	COG0716	Flavodoxin	151
646451542	629	67.2	3	626	1	621	0.0e+00	1021	COG0445	tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA	621
646451543	206	47.39	1	204	1	211	2.0e-62	232	COG0357	16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B)	215
646451544	127	52.76	1	126	2	127	9.0e-18	82.6	COG3312	FoF1-type ATP synthase assembly protein I	128
646451545	263	46.62	3	263	6	246	3.0e-52	198	COG0356	FoF1-type ATP synthase, membrane subunit a	246
646451547	156	48.05	3	156	5	158	2.0e-18	85.3	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	161
646451548	177	43.26	1	176	1	178	2.0e-43	168	COG0712	FoF1-type ATP synthase, delta subunit	178
646451549	513	66.28	1	513	1	502	0.0e+00	824	COG0056	FoF1-type ATP synthase, alpha subunit	504
646451550	287	59.09	5	287	1	286	2.0e-106	378	COG0224	FoF1-type ATP synthase, gamma subunit	287
646451551	460	77.85	1	460	1	465	0.0e+00	836	COG0055	FoF1-type ATP synthase, beta subunit	468
646451552	140	55.47	1	136	1	135	8.0e-37	146	COG0355	FoF1-type ATP synthase, epsilon subunit	135
646451554	456	58.39	4	456	1	459	0.0e+00	651	COG1207	Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	460
646451555	611	54.49	1	611	1	597	0.0e+00	820	COG0449	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains	597
646451559	261	23.63	32	260	2	228	3.0e-17	82.3	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
646451561	84	34.18	1	79	1	79	5.0e-09	53	COG0236	Acyl carrier protein	80
646451562	196	44.81	16	194	10	192	3.0e-33	135	COG4648	Uncharacterized membrane protein	201
646451563	462	22.36	28	459	37	521	5.0e-37	149	COG0365	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase	528
646451564	121	23.08	1	121	21	146	9.0e-12	62.6	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
646451565	569	52.58	251	560	3	303	1.0e-93	337	COG4261	Predicted acyltransferase, LPLAT superfamily	309
646451566	142	25.37	6	138	1	131	6.0e-21	93.4	COG0824	Acyl-CoA thioesterase FadM	137
646451568	774	46.27	2	774	1	788	0.0e+00	593	COG4258	Predicted exporter	788
646451570	385	31.57	1	384	4	412	2.0e-68	253	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646451571	166	43.79	13	164	9	157	4.0e-27	114	COG4706	Predicted 3-hydroxylacyl-ACP dehydratase, HotDog domain	161
646451572	243	38.1	1	243	4	251	9.0e-44	170	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646451573	409	42.41	1	408	2	412	7.0e-111	394	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646451574	771	36.61	591	770	3	180	3.0e-35	144	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646451575	346	37.87	1	326	12	318	7.0e-59	221	COG0226	ABC-type phosphate transport system, periplasmic component	318
646451576	319	45.14	3	316	5	310	2.0e-73	269	COG0573	ABC-type phosphate transport system, permease component	310
646451577	295	51.56	12	293	1	288	5.0e-73	267	COG0581	ABC-type phosphate transport system, permease component	292
646451578	258	64.96	5	258	1	253	2.0e-127	448	COG1117	ABC-type phosphate transport system, ATPase component	253
646451579	248	38.3	6	239	5	239	4.0e-47	181	COG0704	Phosphate uptake regulator	240
646451580	278	37.87	1	263	2	272	1.0e-39	157	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
646451581	248	41.2	15	247	9	222	1.0e-50	193	COG0765	ABC-type amino acid transport system, permease component	222
646451582	252	39.07	12	226	8	221	5.0e-44	171	COG0765	ABC-type amino acid transport system, permease component	222
646451583	223	32.74	3	217	1	221	7.0e-40	157	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
646451584	445	62.27	12	441	3	434	4.0e-123	434	COG2252	Xanthine/uracil/vitamin C permease, AzgA family	436
646451585	246	27.8	1	214	2	222	8.0e-20	90.8	COG2091	Phosphopantetheinyl transferase	223
646451586	177	50	1	164	1	152	2.0e-37	148	COG1142	Fe-S-cluster-containing hydrogenase component 2	165
646451587	667	45.61	197	644	1	448	0.0e+00	485	COG0493	NADPH-dependent glutamate synthase beta chain or related oxidoreductase	457
646451588	380	50.65	1	380	2	374	2.0e-127	449	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
646451589	327	30.82	9	282	4	275	4.0e-24	105	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646451590	663	43.65	1	302	2	307	2.0e-92	333	COG0223	Methionyl-tRNA formyltransferase	307
646451591	299	17.88	1	268	19	259	1.0e-10	60.4	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/CDA1 family	267
646451592	552	33.97	11	524	14	533	4.0e-60	226	COG1807	4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of PMT family	535
646451596	203	57.42	4	203	3	211	1.0e-74	272	COG2910	Putative NADH-flavin reductase	211
646451597	128	46.43	14	125	8	119	1.0e-30	125	COG1733	DNA-binding transcriptional regulator, HxlR family	120
646451598	362	48.88	4	357	13	361	2.0e-110	392	COG3185	4-hydroxyphenylpyruvate dioxygenase and related hemolysins	363
646451599	257	20.07	1	254	7	247	4.0e-14	72.1	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
646451600	318	36.86	8	318	15	325	1.0e-72	267	COG4977	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain	328
646451601	630	24.8	97	461	6	388	6.0e-56	212	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
646451602	474	41.83	6	467	1	454	0.0e+00	484	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
646451604	454	53.81	1	454	1	454	0.0e+00	582	COG0486	tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE	454
646451605	543	50.33	247	543	5	308	1.0e-79	291	COG0706	Membrane protein insertase Oxa1/YidC/SpoIIIJ, required for the localization of integral membrane proteins	314
646451606	85	60.53	3	78	1	76	2.0e-26	110	COG0759	Membrane-anchored protein YidD, putatitve component of membrane protein insertase Oxa1/YidC/SpoIIIJ	92
646451607	119	49.57	6	119	1	115	3.0e-27	113	COG0594	RNase P protein component	117
646559355	330	42.06	1	317	1	316	1.0e-90	326	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646559358	263	23.85	41	250	22	225	3.0e-10	58.8	COG2801	Transposase InsO and inactivated derivatives	232
646559372	184	26.67	3	181	56	230	6.0e-19	87.5	COG1802	DNA-binding transcriptional regulator, GntR family	230
646559378	313	46.94	30	311	2	295	2.0e-77	282	COG4227	Antirestriction protein ArdC	316
646559415	268	21.18	1	259	4	281	2.0e-09	56.5	COG1518	CRISPR/Cas system-associated endonuclease Cas1	327
646559418	339	21.21	24	155	5	126	4.0e-07	49.6	COG3415	Transposase	138
