gene_oid	gene_length	percent_identity	query_start	query_end	subj_start	subj_end	evalue	bit_score	cog_id	cog_name	cog_length
644854645	349	47.46	22	348	17	348	6.0e-95	341	COG0252	L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D	351
644854648	311	55.56	2	295	59	349	2.0e-111	395	COG0820	Adenine C2-methylase RlmN of 23S rRNA A2503 and tRNA A37	349
644854650	341	20.88	18	311	3	284	2.0e-36	146	COG1426	Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains	284
644854651	367	64.54	7	367	1	361	0.0e+00	539	COG0821	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE	361
644854652	425	51.73	2	425	1	429	0.0e+00	523	COG0124	Histidyl-tRNA synthetase	429
644854653	204	45.85	1	204	1	205	5.0e-44	170	COG2976	Putative negative regulator of RcsB-dependent stress response	207
644854654	150	27.59	10	150	38	182	2.0e-18	84.7	COG2020	Protein-S-isoprenylcysteine O-methyltransferase Ste14	187
644854656	415	41.4	2	411	1	437	2.0e-86	313	COG2233	Xanthine/uracil permease	451
644854657	208	61.24	1	208	2	210	2.0e-80	292	COG0035	Uracil phosphoribosyltransferase	210
644854659	805	66.41	5	781	3	782	0.0e+00	1194	COG0466	ATP-dependent Lon protease, bacterial type	782
644854661	581	39.4	26	579	13	554	3.0e-112	399	COG0659	Sulfate permease or related transporter, MFS superfamily	554
644854662	211	50.24	6	211	5	210	1.0e-64	239	COG0800	2-keto-3-deoxy-6-phosphogluconate aldolase	211
644854663	215	53.95	1	211	2	204	6.0e-70	257	COG0605	Superoxide dismutase	204
644854664	754	57.47	1	433	13	432	0.0e+00	601	COG0281	Malic enzyme	432
644854665	233	40.34	1	229	3	240	2.0e-69	255	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
644854666	397	18.94	38	385	39	386	4.0e-16	79.5	COG2814	Predicted arabinose efflux permease, MFS family	394
644854667	211	55.29	3	208	1	207	1.0e-73	269	COG4133	ABC-type transport system involved in cytochrome c biogenesis, ATPase component	209
644854668	221	65	1	220	2	221	7.0e-53	200	COG2386	ABC-type transport system involved in cytochrome c biogenesis, permease component	221
644854669	246	43.21	1	242	34	276	5.0e-46	177	COG0755	ABC-type transport system involved in cytochrome c biogenesis, permease component	281
644854670	68	43.08	1	65	1	65	2.0e-16	77.3	COG3114	Heme exporter protein D	67
644854671	172	54.82	1	166	1	153	5.0e-53	200	COG2332	Cytochrome c-type biogenesis protein CcmE	153
644854672	652	59.32	1	648	1	648	0.0e+00	742	COG1138	Cytochrome c biogenesis factor	648
644854673	181	26.15	33	157	1	127	5.0e-10	57.6	COG0526	Thiol-disulfide isomerase or thioredoxin	127
644854674	161	46.88	1	157	1	152	6.0e-48	183	COG3088	Cytochrome c-type biogenesis protein CcmH/NrfF	153
644854675	306	33.67	1	297	1	286	2.0e-66	246	COG4235	Cytochrome c-type biogenesis protein CcmH/NrfG	287
644854678	537	59.29	27	531	13	497	0.0e+00	736	COG3303	Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit	501
644854680	225	45.23	31	225	3	200	7.0e-56	210	COG0437	Fe-S-cluster-containing dehydrogenase component	203
644854681	321	51.55	3	321	1	305	5.0e-72	264	COG3301	Formate-dependent nitrite reductase, membrane component NrfD	305
644854682	636	48.22	1	634	1	644	0.0e+00	592	COG1138	Cytochrome c biogenesis factor	648
644854683	176	25.58	30	153	1	127	3.0e-11	61.5	COG0526	Thiol-disulfide isomerase or thioredoxin	127
644854684	349	49.18	4	125	7	128	7.0e-42	164	COG3088	Cytochrome c-type biogenesis protein CcmH/NrfF	153
644854685	403	50.86	3	395	1	404	0.0e+00	507	COG2081	Predicted flavoprotein YhiN	408
644854686	675	48.38	7	557	4	537	0.0e+00	560	COG1292	Choline-glycine betaine transporter	537
644854687	369	21.32	32	356	15	318	3.0e-30	126	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
644854689	97	38.03	28	97	1	71	3.0e-10	56.5	COG2608	Copper chaperone CopZ	71
644854690	189	58.39	31	189	21	179	2.0e-49	189	COG2032	Cu/Zn superoxide dismutase	179
644854692	358	38.57	1	356	1	362	4.0e-111	394	COG1195	Recombinational DNA repair ATPase RecF	363
644854693	366	41.96	1	366	1	364	1.0e-98	353	COG0592	DNA polymerase III sliding clamp (beta) subunit, PCNA homolog	364
644854694	453	49.89	9	449	1	408	5.0e-130	458	COG0593	Chromosomal replication initiation ATPase DnaA	408
644854697	122	45.3	6	121	1	117	4.0e-24	103	COG0594	RNase P protein component	117
644854699	451	55.26	1	451	3	454	0.0e+00	566	COG0486	tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE	454
644854700	175	33.53	1	155	2	168	6.0e-36	143	COG0602	Organic radical activating enzyme	212
644854703	708	44.2	3	708	2	699	0.0e+00	884	COG1328	Anaerobic ribonucleoside-triphosphate reductase	700
644854704	2100	22.37	1566	2100	210	715	1.0e-05	47.5	COG5295	Autotransporter adhesin	715
644854705	595	42.31	4	595	15	608	0.0e+00	658	COG1022	Long-chain acyl-CoA synthetase (AMP-forming)	613
644854707	1158	50.26	3	1156	1	1139	0.0e+00	1363	COG0587	DNA polymerase III, alpha subunit	1139
644854708	276	44.49	1	253	1	247	9.0e-77	280	COG0121	Predicted glutamine amidotransferase	252
644854709	449	44.06	22	449	1	411	0.0e+00	518	COG0334	Glutamate dehydrogenase/leucine dehydrogenase	411
644854711	457	53.39	1	457	3	458	0.0e+00	638	COG0165	Argininosuccinate lyase	459
644854712	262	32.87	1	262	6	289	3.0e-50	192	COG3774	Mannosyltransferase OCH1 or related enzyme	347
644854716	480	44.89	6	474	1	472	0.0e+00	515	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	472
644854718	69	55.22	3	69	1	67	9.0e-21	91.7	COG1278	Cold shock protein, CspA family	67
644854719	319	39.75	13	318	1	310	6.0e-55	208	COG0524	Sugar or nucleoside kinase, ribokinase family	311
644854720	198	22.88	6	152	8	151	4.0e-12	64.6	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
644854721	265	29.26	1	265	3	253	2.0e-13	70	COG0730	Uncharacterized membrane protein YfcA	258
644854722	265	45.39	1	265	1	281	4.0e-67	248	COG0682	Prolipoprotein diacylglyceryltransferase	287
644854723	283	38.87	1	283	3	268	9.0e-92	330	COG0207	Thymidylate synthase	268
644854724	174	57.93	9	153	8	152	2.0e-52	198	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
644854725	186	47.34	1	186	1	169	2.0e-33	135	COG3078	Ribosome assembly protein YihI, activator of Der GTPase	169
644854727	455	41.24	12	443	1	414	2.0e-119	422	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
644854729	263	55.56	3	262	2	251	2.0e-82	298	COG0149	Triosephosphate isomerase	251
644854730	285	77.66	6	285	1	282	0.0e+00	523	COG0447	1,4-Dihydroxy-2-naphthoyl-CoA synthase	282
644854731	437	65.54	108	432	2	320	0.0e+00	528	COG1441	O-succinylbenzoate synthase	321
644854732	158	59.72	6	149	2	145	9.0e-59	219	COG0757	3-dehydroquinate dehydratase	146
644854733	169	49.34	18	169	1	139	3.0e-26	111	COG0511	Biotin carboxyl carrier protein	140
644854734	448	64.89	1	448	1	449	0.0e+00	642	COG0439	Biotin carboxylase	449
644854736	302	55.22	7	302	3	298	2.0e-116	412	COG1159	GTPase Era, involved in 16S rRNA processing	298
644854737	226	52.38	1	226	3	232	3.0e-73	268	COG0571	dsRNA-specific ribonuclease	235
644854738	340	35.38	78	195	1	130	7.0e-15	75	COG0681	Signal peptidase I	166
644854739	605	71.91	8	604	6	603	0.0e+00	1091	COG0481	Translation elongation factor EF-4, membrane-bound GTPase	603
644854741	127	86.61	1	127	1	127	7.0e-66	242	COG3445	Autonomous glycyl radical cofactor GrcA	127
644854742	222	64.38	1	219	4	222	7.0e-103	366	COG0692	Uracil DNA glycosylase	223
644854743	259	58.98	1	256	1	252	3.0e-87	315	COG3022	Cytoplasmic iron level regulating protein YaaA, DUF328/UPF0246 family	253
644854745	307	36.55	11	299	11	296	1.0e-58	220	COG0053	Divalent metal cation (Fe/Co/Zn/Cd) transporter	304
644854746	321	59.55	1	303	1	314	7.0e-113	400	COG0205	6-phosphofructokinase	347
644854747	391	33.94	3	383	68	432	6.0e-87	314	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
644854748	348	39.78	1	347	5	352	3.0e-83	302	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
644854749	117	26.4	1	116	1	123	8.0e-15	72.3	COG5633	Uncharacterized conserved protein YcfL	123
644854750	116	44.25	3	113	1	110	3.0e-27	113	COG0537	Diadenosine tetraphosphate (Ap4A) hydrolase or other HIT family hydrolase	138
644854751	283	50.91	10	283	4	260	3.0e-72	265	COG2116	Formate/nitrite transporter FocA, FNT family	265
644854752	770	65.27	8	768	7	754	0.0e+00	1111	COG1882	Pyruvate-formate lyase	755
644854753	95	32.63	1	95	3	97	5.0e-18	82.7	COG1359	Quinol monooxygenase YgiN	100
644854754	246	38.46	1	246	15	257	5.0e-72	264	COG1180	Pyruvate-formate lyase-activating enzyme	260
644854756	287	22.35	18	281	31	285	3.0e-10	59.1	COG5006	Threonine/homoserine efflux transporter RhtA	292
644854757	470	31.86	6	470	1	449	1.0e-67	250	COG2132	Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA)	451
644854758	247	33.05	6	238	2	236	3.0e-40	158	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
644854759	243	49.36	5	234	1	232	7.0e-69	254	COG2908	UDP-2,3-diacylglucosamine pyrophosphatase LpxH	237
644854760	168	57.14	1	168	1	168	5.0e-44	170	COG5413	Uncharacterized integral membrane protein	168
644854761	225	30.94	1	222	6	216	5.0e-42	164	COG2964	Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains	220
644854762	404	37.41	1	399	8	415	4.0e-53	202	COG0814	Amino acid permease	415
644854763	458	56.62	1	458	5	470	0.0e+00	692	COG3033	Tryptophanase	471
644854764	188	43.51	1	131	1	131	7.0e-40	156	COG0231	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)	131
644854765	339	49.71	1	339	1	339	2.0e-123	435	COG1509	L-lysine 2,3-aminomutase (EF-P beta-lysylation pathway)	369
644854766	438	33.33	208	438	1	242	4.0e-26	112	COG3061	Cell envelope opacity-associated protein A (function unknown)	242
644854769	271	47.92	6	268	4	264	1.0e-72	266	COG0345	Pyrroline-5-carboxylate reductase	266
644854770	386	19.47	1	374	10	382	1.0e-07	51	COG2814	Predicted arabinose efflux permease, MFS family	394
644854771	297	55.18	1	297	3	300	2.0e-112	399	COG4974	Site-specific recombinase XerD	300
644854772	432	45.7	1	432	1	441	3.0e-109	388	COG0544	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)	441
644854773	295	29.8	1	295	2	288	9.0e-44	170	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
644854774	419	30.85	82	355	1	280	1.0e-51	197	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
644854775	249	29.96	11	230	2	218	4.0e-33	135	COG2091	Phosphopantetheinyl transferase	223
644854776	424	33.18	1	424	1	410	8.0e-99	354	COG0498	Threonine synthase	411
644854778	314	42.81	1	313	3	297	7.0e-99	353	COG0083	Homoserine kinase	299
644854780	462	22.88	8	459	12	403	3.0e-51	196	COG1488	Nicotinic acid phosphoribosyltransferase	405
644854781	234	50.22	2	232	1	228	9.0e-80	289	COG0325	Uncharacterized pyridoxal phosphate-containing protein, affects Ilv metabolism, UPF0001 family	228
644854782	334	32.26	1	333	4	342	2.0e-72	266	COG3317	Uncharacterized lipoprotein	342
644854783	297	51.86	4	297	2	296	2.0e-94	339	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
644854784	155	54.84	1	155	1	155	2.0e-55	207	COG1225	Peroxiredoxin	157
644854789	616	72.4	6	610	1	603	0.0e+00	1054	COG1217	Predicted membrane GTPase involved in stress response	603
644854790	469	47.47	3	469	1	441	0.0e+00	513	COG0174	Glutamine synthetase	443
644854791	242	48.77	1	241	7	249	4.0e-53	201	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
644854792	221	68.37	3	217	12	226	3.0e-100	357	COG3066	DNA mismatch repair protein MutH	229
644854793	179	37.72	4	159	2	168	2.0e-41	161	COG0350	O6-methylguanine-DNA--protein-cysteine methyltransferase	168
644854796	96	57.29	1	96	3	98	1.0e-26	111	COG3691	Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family	98
644854797	463	30.92	11	462	2	457	7.0e-58	218	COG0471	Di- and tricarboxylate transporter	461
644854799	166	41.21	3	162	11	175	5.0e-44	170	COG0684	Regulator of RNase E activity RraA	210
644854800	301	41.72	1	301	3	300	3.0e-71	262	COG1575	1,4-dihydroxy-2-naphthoate octaprenyltransferase	303
644854801	245	52.47	1	162	1	154	2.0e-49	189	COG1720	tRNA (Thr-GGU) A37 N-methylase	156
644854802	128	35.48	1	123	1	124	3.0e-20	91	COG0789	DNA-binding transcriptional regulator, MerR family	124
644854803	70	51.43	1	70	1	70	4.0e-12	63.1	COG2608	Copper chaperone CopZ	71
644854805	719	42.47	1	715	1	709	0.0e+00	695	COG2217	Cation transport ATPase	713
644854806	281	63.26	17	280	2	263	1.0e-95	343	COG3739	Uncharacterized membrane protein YoaT, DUF817 family	263
644854807	415	71.22	10	412	1	397	0.0e+00	688	COG1219	ATP-dependent protease Clp, ATPase subunit	408
644854808	193	73.06	1	193	1	193	1.0e-86	312	COG0740	ATP-dependent protease ClpP, protease subunit	200
644854810	525	28.21	16	499	22	517	9.0e-62	231	COG2194	Phosphoethanolamine transferase for periplasmic glucans (OPG), alkaline phosphatase superfamily	555
644854811	757	30.38	1	477	3	518	6.0e-125	442	COG2918	Gamma-glutamylcysteine synthetase	518
644854812	592	19.4	6	206	4	176	2.0e-16	80.9	COG4961	Flp pilus assembly protein TadG	185
644854815	253	26.61	6	249	4	249	5.0e-38	151	COG5010	Flp pilus assembly protein TadD, contains TPR repeats	257
644854817	294	25.57	1	294	1	309	9.0e-62	230	COG4965	Flp pilus assembly protein TadB	309
644854818	426	56.23	35	379	11	350	1.0e-118	420	COG4962	Pilus assembly protein, ATPase of CpaF family	355
644854819	373	23.53	1	373	1	365	3.0e-62	232	COG4963	Flp pilus assembly protein, ATPase CpaE	366
644854821	460	31.1	17	451	20	441	5.0e-87	315	COG4964	Flp pilus assembly protein, secretin CpaC	455
644854823	142	32.9	7	141	7	161	1.0e-12	65.6	COG4960	Flp pilus assembly protein, protease CpaA	168
644854826	364	49.14	5	354	13	348	5.0e-110	391	COG1702	Phosphate starvation-inducible protein PhoH, predicted ATPase	348
644854827	154	49.67	4	153	1	153	5.0e-43	167	COG0319	ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme	153
644854829	645	30.44	3	645	34	731	0.0e+00	494	COG1444	tRNA(Met) C34 N-acetyltransferase TmcA	758
644854831	1151	53.35	14	1147	8	1136	0.0e+00	1492	COG1197	Transcription-repair coupling factor (superfamily II helicase)	1139
644854832	131	27.34	3	126	6	133	2.0e-18	84.7	COG3791	Uncharacterized conserved protein	133
644854834	194	59.78	2	179	1	176	2.0e-70	258	COG0279	Phosphoheptose isomerase	176
644854836	244	69.01	1	242	1	242	2.0e-111	395	COG4161	ABC-type arginine transport system, ATPase component	242
644854837	239	32.69	1	237	5	263	2.0e-34	139	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
644854838	221	50	1	219	2	229	7.0e-69	253	COG4215	ABC-type arginine transport system, permease component	230
644854839	227	54.05	2	221	6	227	4.0e-70	257	COG4160	ABC-type arginine/histidine transport system, permease component	228
644854841	206	32.56	1	204	50	263	6.0e-32	130	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
644854843	531	35.41	1	527	3	568	2.0e-124	439	COG1966	Carbon starvation protein CstA	575
644854844	152	47.37	1	152	1	146	6.0e-45	173	COG2001	MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity	146
644854845	322	53.75	8	322	3	313	9.0e-116	409	COG0275	16S rRNA C1402 N4-methylase RsmH	314
644854846	105	50.48	2	105	1	105	7.0e-26	108	COG3116	Cell division protein FtsL, interacts with FtsB, FtsL and FtsQ	105
644854847	607	35.44	29	584	1	597	7.0e-118	418	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
644854848	488	46.81	21	486	13	472	0.0e+00	490	COG0769	UDP-N-acetylmuramyl tripeptide synthase	475
644854849	459	43.82	2	456	1	451	8.0e-128	450	COG0770	UDP-N-acetylmuramyl pentapeptide synthase	451
644854850	361	43.99	27	361	6	316	2.0e-59	222	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
644854851	438	44.99	1	432	3	444	0.0e+00	469	COG0771	UDP-N-acetylmuramoylalanine-D-glutamate ligase	448
644854852	396	41.24	21	387	11	376	5.0e-84	305	COG0772	Bacterial cell division protein FtsW, lipid II flippase	381
644854853	354	49.58	3	354	1	356	6.0e-104	371	COG0707	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	357
644854854	476	53.76	12	473	1	457	0.0e+00	601	COG0773	UDP-N-acetylmuramate-alanine ligase	459
644854855	309	49.37	6	307	1	316	6.0e-93	334	COG1181	D-alanine-D-alanine ligase and related ATP-grasp enzymes	317
644854856	255	34.5	1	251	3	256	2.0e-45	176	COG1589	Cell division septal protein FtsQ	269
644854857	435	46.28	6	418	4	410	5.0e-122	431	COG0849	Cell division ATPase FtsA	418
644854858	427	47.78	5	364	2	338	1.0e-94	340	COG0206	Cell division GTPase FtsZ	338
644854859	305	68.87	1	302	1	300	0.0e+00	505	COG0774	UDP-3-O-acyl-N-acetylglucosamine deacetylase	300
644854862	387	42.09	106	382	5	279	1.0e-94	339	COG0077	Prephenate dehydratase	279
644854863	211	39.37	1	211	1	220	3.0e-37	148	COG2979	Uncharacterized membrane protein YebE, DUF533 family	225
644854865	627	66.03	2	627	1	619	0.0e+00	867	COG0326	Molecular chaperone, HSP90 family	623
644854866	114	39.66	1	114	2	116	9.0e-28	115	COG1393	Arsenate reductase and related proteins, glutaredoxin family	117
644854868	651	15.89	58	651	87	768	1.0e-22	101	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
644854869	377	35.77	1	375	11	407	2.0e-84	306	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
644854870	228	41.94	1	217	24	239	2.0e-51	195	COG1876	LD-carboxypeptidase LdcB, LAS superfamily	241
644854872	274	31.65	14	274	1	270	5.0e-35	141	COG1409	3',5'-cyclic AMP phosphodiesterase CpdA	301
644854873	223	44.39	7	215	4	212	2.0e-73	268	COG0603	7-cyano-7-deazaguanine synthase (queuosine biosynthesis)	222
644854874	718	47.24	1	380	2	377	0.0e+00	471	COG0116	23S rRNA G2445 N2-methylase RlmL	381
644854875	462	40.95	1	396	1	347	5.0e-113	401	COG0826	Collagenase-like protease, PrtC family	347
644854876	112	21.74	1	110	5	119	1.0e-11	61.7	COG1917	Cupin domain protein related to quercetin dioxygenase	131
644854878	254	38.84	7	246	12	242	5.0e-49	187	COG0847	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease	243
644854879	154	55.56	3	152	2	154	1.0e-50	192	COG0328	Ribonuclease HI	154
644854880	480	34.66	2	474	1	460	2.0e-57	217	COG0471	Di- and tricarboxylate transporter	461
644854881	465	40.83	11	179	8	176	2.0e-52	200	COG3697	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase)	182
644854881	465	43.75	185	464	8	285	1.0e-60	227	COG1767	Triphosphoribosyl-dephospho-CoA synthetase	288
644854882	500	75.54	1	500	7	513	0.0e+00	856	COG3051	Citrate lyase, alpha subunit	513
644854883	291	47.57	6	291	1	283	5.0e-84	304	COG2301	Citrate lyase beta subunit	283
644854884	97	55.1	1	95	1	98	1.0e-26	111	COG3052	Citrate lyase, gamma subunit	98
644854885	341	57.53	1	331	4	335	0.0e+00	494	COG3053	Citrate lyase synthetase	352
644854886	298	66.43	1	285	1	284	7.0e-117	413	COG4535	Mg2+ and Co2+ transporter CorC, contains CBS pair and CorC-HlyC domains	293
644854887	518	34.5	1	508	10	515	8.0e-112	397	COG0815	Apolipoprotein N-acyltransferase	518
644854888	72	69.44	1	72	1	72	7.0e-26	108	COG0361	Translation initiation factor IF-1	75
644854889	433	36.02	1	431	28	485	5.0e-117	414	COG0260	Leucyl aminopeptidase	485
644854890	139	64.89	3	133	2	132	3.0e-54	204	COG0105	Nucleoside diphosphate kinase	135
644854892	243	33.33	32	243	31	245	4.0e-34	138	COG0489	Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster	265
644854894	1917	39.2	1	547	6	550	0.0e+00	517	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
644854899	223	37.79	8	223	9	217	2.0e-46	178	COG3159	Uncharacterized conserved protein YigA, DUF484 family	218
644854900	432	63.11	2	431	1	430	0.0e+00	677	COG0104	Adenylosuccinate synthase	430
644854902	506	47.56	6	490	4	489	7.0e-96	344	COG0591	Na+/proline symporter	493
644854903	491	48.78	5	491	3	483	0.0e+00	518	COG1530	Ribonuclease G or E	487
644854904	215	57.67	1	215	1	215	3.0e-81	294	COG2999	Glutaredoxin 2	215
644854905	232	42.8	6	230	16	250	4.0e-58	217	COG0846	NAD-dependent protein deacetylase, SIR2 family	250
644854907	245	31.64	1	245	4	258	2.0e-40	159	COG0725	ABC-type molybdate transport system, periplasmic component	258
644854908	265	34.22	1	262	4	266	5.0e-50	191	COG0555	ABC-type sulfate transport system, permease component	274
644854910	281	34.04	1	281	2	280	1.0e-70	260	COG0157	Nicotinate-nucleotide pyrophosphorylase	280
644854911	482	37.95	16	481	1	454	1.0e-119	424	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
644854912	1923	27.34	238	1923	25	1620	0.0e+00	907	COG2373	Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family	1621
644854913	786	37.03	11	782	7	731	0.0e+00	731	COG4953	Membrane carboxypeptidase/penicillin-binding protein PbpC	733
644854929	442	63.29	1	442	5	448	0.0e+00	533	COG1823	L-cystine uptake protein TcyP, sodium:dicarboxylate symporter family	458
644854930	496	46.6	1	496	1	485	0.0e+00	550	COG0260	Leucyl aminopeptidase	485
644854931	367	36.01	1	350	2	362	1.0e-61	231	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
644854932	355	35.08	1	354	1	362	3.0e-67	249	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
644854933	294	46.76	7	292	1	291	2.0e-82	298	COG0685	5,10-methylenetetrahydrofolate reductase	291
644854935	261	40.31	1	258	10	267	1.0e-48	186	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	274
644854936	257	39.92	9	242	3	254	1.0e-73	270	COG1121	ABC-type Mn2+/Zn2+ transport system, ATPase component	254
644854938	445	39.18	226	414	65	258	4.0e-37	149	COG0739	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain	277
644854941	163	30.26	10	161	8	154	1.0e-23	102	COG2606	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC	155
644854942	316	59.18	1	315	2	314	9.0e-121	426	COG0462	Phosphoribosylpyrophosphate synthetase	314
644854943	423	33.75	2	399	19	403	1.0e-79	290	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
644854944	203	44.39	1	203	1	205	1.0e-56	212	COG3103	Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family	205
644854947	356	30.19	1	354	1	358	4.0e-62	231	COG3025	Inorganic triphosphatase YgiF, contains CYTH and CHAD domains	432
644854948	457	61.05	1	456	1	455	0.0e+00	683	COG1066	Predicted ATP-dependent serine protease	456
644854949	193	48	43	192	6	154	3.0e-39	154	COG1522	DNA-binding transcriptional regulator, Lrp family	154
644854950	205	42.38	1	203	4	211	2.0e-39	155	COG2834	Outer membrane lipoprotein-sorting protein	211
644854951	446	60	4	442	1	436	0.0e+00	633	COG2256	Replication-associated recombination protein RarA (DNA-dependent ATPase)	436
644854953	435	59.59	1	435	1	427	0.0e+00	603	COG0172	Seryl-tRNA synthetase	429
644854954	977	50	10	977	11	955	0.0e+00	1034	COG1391	Glutamine synthetase adenylyltransferase	963
644854955	763	20.96	242	754	196	724	2.0e-50	194	COG1203	CRISPR/Cas system-associated endonuclease/helicase Cas3	733
644854959	288	32.32	1	254	1	246	2.0e-39	156	COG3649	CRISPR/Cas system type I-B associated protein Csh2, Cas7 group, RAMP superfamily	283
644854960	221	25.68	17	199	15	190	5.0e-24	104	COG1468	CRISPR/Cas system-associated exonuclease Cas4, RecB family	190
644854962	337	36.83	6	336	4	327	6.0e-65	241	COG1518	CRISPR/Cas system-associated endonuclease Cas1	327
644854963	97	33.33	1	93	1	89	2.0e-14	71	COG1343	CRISPR/Cas system-associated endoribonuclease Cas2	89
644854964	554	25.97	2	455	1	391	3.0e-50	193	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
644854965	263	23.51	1	263	10	257	1.0e-21	97	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	259
644854966	1257	38.54	498	1257	5	750	0.0e+00	727	COG0058	Glucan phosphorylase	750
644854967	237	32.75	1	229	6	232	6.0e-42	164	COG2188	DNA-binding transcriptional regulator, GntR family	236
644854968	757	61.45	424	755	1	330	5.0e-128	452	COG0620	Methionine synthase II (cobalamin-independent)	330
644854970	310	32.23	6	303	1	297	2.0e-37	150	COG0583	DNA-binding transcriptional regulator, LysR family	297
644854971	243	30.47	9	240	6	238	2.0e-44	172	COG1296	Predicted branched-chain amino acid permease (azaleucine resistance)	238
644854972	110	58.49	2	107	1	105	1.0e-27	114	COG1687	Branched-chain amino acid transport protein AzlD	106
644854973	930	23.7	32	468	8	423	1.0e-50	195	COG0612	Predicted Zn-dependent peptidase	438
644854974	788	13.9	95	788	102	768	1.0e-06	48.8	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
644854975	297	36.81	8	291	11	298	6.0e-76	277	COG2990	Uncharacterized protein VirK/YbjX	300
644854976	225	60.99	1	222	3	222	1.0e-79	289	COG0283	Cytidylate kinase	222
644854977	548	59.3	1	541	1	541	0.0e+00	591	COG0539	Ribosomal protein S1	541
644854978	94	50.54	1	93	2	93	2.0e-26	110	COG0776	Bacterial nucleoid DNA-binding protein	94
644854979	98	54.74	2	96	1	95	5.0e-27	112	COG3771	Uncharacterized membrane protein YciS, DUF1049 family	97
644854980	396	52.64	1	396	1	389	0.0e+00	514	COG2956	Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain	389
644854981	105	51.92	5	105	1	103	9.0e-22	95.3	COG0023	Translation initiation factor 1 (eIF-1/SUI1)	104
644854982	91	36.46	1	89	27	122	1.0e-07	48	COG3094	Uncharacterized membrane protein SirB2	129
644854983	885	57.78	1	870	1	804	0.0e+00	1054	COG0188	DNA gyrase/topoisomerase IV, subunit A	804
644854984	251	54.47	1	243	10	240	8.0e-87	313	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	243
644854985	146	44.76	1	143	4	145	4.0e-37	147	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
644854986	174	40.59	1	168	1	151	5.0e-34	137	COG0716	Flavodoxin	151
644854988	266	23.95	18	259	21	282	6.0e-25	108	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
644854989	205	47.52	1	202	1	181	2.0e-64	238	COG3057	Negative regulator of replication initiation	181
644854990	475	28.12	14	472	24	527	1.0e-76	280	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
644854991	1108	36.33	206	1105	2	823	0.0e+00	661	COG3264	Small-conductance mechanosensitive channel	835
644854992	357	61.88	2	357	1	357	0.0e+00	547	COG0082	Chorismate synthase	369
644854993	290	59.36	8	290	3	284	8.0e-120	423	COG3770	Murein endopeptidase	284
644854994	255	33.72	2	253	1	257	1.0e-17	83.5	COG0730	Uncharacterized membrane protein YfcA	258
644854995	318	39.4	16	314	2	303	2.0e-91	328	COG1560	Lauroyl/myristoyl acyltransferase	308
644854996	203	45.81	24	202	1	179	6.0e-50	190	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	179
644854997	680	42.86	1	444	1	455	7.0e-125	441	COG2812	DNA polymerase III, gamma/tau subunits	515
644854998	286	34.23	68	281	86	304	5.0e-29	122	COG3021	Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily	309
644854999	117	28.69	1	117	7	128	2.0e-23	100	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
644855003	659	56.36	1	658	1	644	0.0e+00	995	COG4776	Exoribonuclease II	645
644855004	262	64.86	1	259	1	258	1.0e-112	399	COG0623	Enoyl-[acyl-carrier-protein] reductase (NADH)	259
644855005	251	47.04	1	251	1	250	4.0e-73	267	COG0327	Putative GTP cyclohydrolase 1 type 2, NIF3 family	250
644855006	209	33.02	8	209	1	212	4.0e-43	167	COG0602	Organic radical activating enzyme	212
644855007	141	38.1	1	141	2	126	2.0e-26	111	COG0720	6-pyruvoyl-tetrahydropterin synthase	127
644855009	204	54.11	1	204	3	207	2.0e-56	211	COG4832	Uncharacterized protein	207
644855010	316	37.59	24	311	1	279	9.0e-61	227	COG2890	Methylase of polypeptide chain release factors	280
644855011	168	45.14	1	168	6	180	2.0e-46	178	COG2840	DNA-nicking endonuclease, Smr domain	184
644855012	713	27.14	4	711	6	664	3.0e-115	409	COG1289	Uncharacterized membrane protein YccC	674
644855013	153	54.48	5	148	1	145	5.0e-43	166	COG3304	Uncharacterized membrane protein YccF, DUF307 family	145
644855014	152	65.49	8	149	1	142	7.0e-64	236	COG1803	Methylglyoxal synthase	142
644855015	223	43.5	2	223	1	216	2.0e-61	229	COG3110	Uncharacterized conserved protein YccT, UPF0319 family	216
644855016	90	50.56	1	89	3	91	3.0e-24	103	COG1254	Acylphosphatase	92
644855017	282	45.76	7	276	4	274	1.0e-53	203	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	274
644855018	285	45.62	1	273	1	274	3.0e-49	188	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	274
644855019	296	47.43	4	256	1	252	1.0e-87	316	COG1121	ABC-type Mn2+/Zn2+ transport system, ATPase component	254
644855020	293	44.07	1	293	10	303	9.0e-85	306	COG0803	ABC-type Zn uptake system ZnuABC, Zn-binding component ZnuA	303
644855021	109	69.72	1	109	3	111	9.0e-45	171	COG2920	Sulfur relay (sulfurtransferase) protein, DsrC/TusE family	111
644855022	220	32.74	8	220	11	233	1.0e-24	106	COG0670	Integral membrane protein, interacts with FtsH	233
644855023	135	48.89	2	135	1	135	2.0e-34	137	COG3105	Uncharacterized membrane-anchored protein YhcB, DUF1043 family	138
644855024	102	34.41	1	92	1	80	7.0e-09	52.2	COG5645	Uncharacterized conserved protein YceK	80
644855025	587	42.45	1	421	3	397	6.0e-122	431	COG1944	Ribosomal protein S12 methylthiotransferase accessory factor YcaO	398
644855027	110	47.46	2	60	1	59	5.0e-14	69.6	COG3422	Uncharacterized conserved protein YegP, UPF0339 family	59
644855028	497	37	1	413	5	393	2.0e-75	277	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
644855030	233	26.42	3	215	17	247	6.0e-21	94.5	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
644855031	434	44.27	1	434	1	414	3.0e-116	412	COG0373	Glutamyl-tRNA reductase	414
644855032	407	28.57	83	395	5	309	5.0e-52	198	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
644855037	590	53.58	47	590	4	539	0.0e+00	661	COG0405	Gamma-glutamyltranspeptidase	539
644855039	445	36.08	9	430	1	403	1.0e-130	460	COG0137	Argininosuccinate synthase	403
644855040	276	22.15	8	266	8	296	2.0e-20	93.5	COG0451	Nucleoside-diphosphate-sugar epimerase	314
644855041	286	33.92	3	285	1	246	9.0e-68	250	COG0152	Phosphoribosylaminoimidazole-succinocarboxamide synthase	247
644855042	337	19.72	1	337	1	354	3.0e-32	132	COG3203	Outer membrane protein (porin)	354
644855044	527	74.19	1	527	2	528	0.0e+00	932	COG4108	Peptide chain release factor RF-3	528
644855045	298	37.88	55	177	5	134	2.0e-33	136	COG0295	Cytidine deaminase	134
644855046	365	44.03	1	365	2	363	1.0e-82	300	COG0687	Spermidine/putrescine-binding periplasmic protein	363
644855047	257	44.05	2	252	9	260	5.0e-60	224	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
644855048	290	47.89	5	286	1	284	3.0e-65	242	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
644855049	400	50.27	34	396	1	352	4.0e-120	425	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
644855050	416	42.55	5	413	2	414	1.0e-112	400	COG2195	Di- or tripeptidase	414
644855051	884	43.13	6	577	3	553	0.0e+00	605	COG3008	Paraquat-inducible protein B	553
644855053	252	52.88	48	252	1	208	4.0e-64	238	COG3109	sRNA-binding protein	208
644855055	186	51.61	1	186	1	185	3.0e-62	231	COG3108	Uncharacterized conserved protein YcbK, DUF882 family	185
644855056	212	31.46	1	207	12	224	1.0e-32	133	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
644855057	934	61.51	5	934	1	906	0.0e+00	1389	COG0567	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	906
644855058	401	53.96	1	399	1	403	4.0e-121	428	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	404
644855060	389	58.87	1	387	1	386	0.0e+00	517	COG0045	Succinyl-CoA synthetase, beta subunit	387
644855061	292	69.07	1	290	1	291	2.0e-121	429	COG0074	Succinyl-CoA synthetase, alpha subunit	293
644855067	210	24.59	1	122	3	121	9.0e-12	63.8	COG3070	Transcriptional regulator of competence genes, TfoX/Sxy family	121
644855068	305	55.19	1	305	1	307	8.0e-105	373	COG3058	Formate dehydrogenase maturation protein FdhE	308
644855069	138	36.76	1	136	1	127	3.0e-25	107	COG3111	Predicted periplasmic protein YdeI with OB-fold, BOF family	128
644855070	223	42.61	1	220	1	229	6.0e-59	220	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
644855071	455	28.29	141	439	18	316	3.0e-31	129	COG0642	Signal transduction histidine kinase	336
644855072	214	40.37	1	214	1	178	7.0e-49	187	COG0563	Adenylate kinase or related kinase	178
644855074	113	51.33	1	113	1	113	4.0e-31	126	COG0375	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)	115
644855075	338	48.22	1	336	1	329	0.0e+00	496	COG1087	UDP-glucose 4-epimerase	329
644855077	443	45.77	6	441	3	436	2.0e-100	359	COG2252	Xanthine/uracil/vitamin C permease, AzgA family	436
644855078	436	28.34	1	301	1	298	6.0e-46	178	COG0037	tRNA(Ile)-lysidine synthase TilS/MesJ	298
644855079	285	49.82	2	285	1	281	6.0e-94	337	COG2240	Pyridoxal/pyridoxine/pyridoxamine kinase	281
644855080	317	68.57	2	316	1	314	0.0e+00	506	COG0825	Acetyl-CoA carboxylase alpha subunit	317
644855081	320	22.65	23	319	7	281	2.0e-15	76.7	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
644855086	264	25.29	9	259	13	263	2.0e-21	96.3	COG5532	Uncharacterized conserved protein YfdQ, DUF2303 family	269
644855097	157	37.96	4	111	3	110	9.0e-25	106	COG4226	Predicted nuclease of the RNAse H fold, HicB family	111
644855098	231	28.89	10	231	1	213	1.0e-27	116	COG2932	Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains	214
644855101	235	31.03	112	226	8	122	6.0e-17	81.2	COG3645	Phage antirepressor protein YoqD, KilAC domain	135
644855107	120	26.92	5	120	5	131	5.0e-11	59.9	COG4570	Holliday junction resolvase RusA (prophage-encoded endonuclease)	132
644855110	175	38.62	23	163	6	149	1.0e-27	116	COG3772	Phage-related lysozyme (muramidase), GH24 family	152
644855114	503	27.31	4	480	37	523	3.0e-67	249	COG4626	Phage terminase-like protein, large subunit, contains N-terminal HTH domain	546
644855115	412	30.17	10	397	4	394	1.0e-60	227	COG4695	Phage portal protein BeeE	398
644855116	219	30.17	13	178	19	192	6.0e-20	91.2	COG3740	Phage head maturation protease	194
644855117	397	22.67	8	331	26	354	1.0e-05	45	COG4653	Predicted phage phi-C31 gp36 major capsid-like protein	422
644855118	120	34.95	14	116	3	105	1.0e-19	88.5	COG5614	Bacteriophage head-tail adaptor	109
644855127	111	38.74	1	111	1	110	4.0e-21	93.5	COG4718	Phage-related protein	111
644855128	244	51.05	5	243	3	230	3.0e-79	288	COG4672	Phage-related protein	231
644855129	253	33.65	1	100	2	105	2.0e-14	73.3	COG1310	Proteasome lid subunit RPN8/RPN11, contains Jab1/MPN domain metalloenzyme (JAMM) motif	134
644855130	173	31.4	1	167	32	198	8.0e-22	96.9	COG4723	Phage-related protein, tail component	198
644855133	399	21.6	102	370	8	281	1.0e-09	57.9	COG4974	Site-specific recombinase XerD	300
644855135	519	68.24	202	519	2	315	0.0e+00	562	COG0519	GMP synthase, PP-ATPase domain/subunit	315
644855138	452	61.21	1	445	2	446	4.0e-127	448	COG3069	C4-dicarboxylate transporter	451
644855144	488	30	258	477	1	170	1.0e-35	144	COG0516	IMP dehydrogenase/GMP reductase	170
644855145	310	38.24	78	309	2	237	5.0e-53	201	COG0340	Biotin-(acetyl-CoA carboxylase) ligase	238
644855147	267	52.45	2	265	1	261	5.0e-97	347	COG0351	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	263
644855148	333	46.29	1	333	3	336	9.0e-105	373	COG4143	ABC-type thiamine transport system, periplasmic component	336
644855149	542	35.04	11	527	9	529	1.0e-81	297	COG1178	ABC-type Fe3+ transport system, permease component	540
644855150	211	60.95	1	210	1	210	8.0e-85	306	COG3840	ABC-type thiamine transport system, ATPase component	231
644855151	334	54.29	9	332	3	326	6.0e-119	420	COG0502	Biotin synthase or related enzyme	335
644855152	762	18.18	3	362	34	375	8.0e-12	66.3	COG1061	Superfamily II DNA or RNA helicase	442
644855155	488	38.21	9	403	14	393	5.0e-69	255	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
644855155	488	43.59	411	487	1	78	7.0e-17	82.3	COG1264	Phosphotransferase system IIB components	88
644855156	377	57.22	1	377	1	381	0.0e+00	466	COG3055	N-acetylneuraminic acid mutarotase	381
644855158	616	50	237	614	1	378	3.0e-108	385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component	379
644855159	328	42.17	1	328	2	331	1.0e-89	322	COG1638	TRAP-type C4-dicarboxylate transport system, periplasmic component	332
644855160	234	61.67	8	232	3	229	3.0e-91	327	COG3010	Putative N-acetylmannosamine-6-phosphate epimerase	229
644855161	294	33.23	1	294	6	313	2.0e-49	189	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
644855162	289	41.26	3	288	1	281	5.0e-67	247	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
644855163	292	33.56	1	292	2	295	3.0e-72	265	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
644855164	267	40.64	1	249	1	238	2.0e-66	245	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	238
644855165	381	50.26	2	381	1	380	1.0e-122	433	COG1820	N-acetylglucosamine-6-phosphate deacetylase	380
644855167	166	60.76	1	158	1	158	4.0e-61	227	COG2077	Peroxiredoxin	158
644855168	353	44.65	1	323	1	320	4.0e-102	364	COG0276	Protoheme ferro-lyase (ferrochelatase)	320
644855169	140	31.62	3	137	2	137	7.0e-31	126	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
644855170	1028	29.39	28	546	8	459	2.0e-78	288	COG0277	FAD/FMN-containing dehydrogenase	459
644855171	346	33	146	344	2	189	6.0e-31	128	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
644855172	193	48.69	1	190	1	185	3.0e-52	197	COG1704	Uncharacterized conserved protein	185
644855173	149	34.64	1	147	59	211	6.0e-34	136	COG3762	Uncharacterized membrane protein	213
644855174	262	36.63	8	262	3	271	5.0e-51	194	COG1512	Uncharacterized membrane protein YgcG, contains a TPM-fold domain	271
644855175	109	64.42	1	103	2	105	1.0e-44	171	COG0278	Glutaredoxin-related protein	105
644855176	167	63.95	21	166	1	147	1.0e-33	136	COG2707	Uncharacterized membrane protein, DUF441 family	151
644855177	127	52.03	5	127	5	122	1.0e-22	98.7	COG2363	Uncharacterized membrane protein YgdD, TMEM256/DUF423 family	124
644855178	1333	37.43	43	995	9	844	0.0e+00	830	COG1643	HrpA-like RNA helicase	845
644855181	167	28	26	148	2	126	4.0e-12	64.2	COG0526	Thiol-disulfide isomerase or thioredoxin	127
644855182	227	48.23	5	221	1	226	1.0e-73	269	COG1136	ABC-type lipoprotein export system, ATPase component	226
644855183	379	20.87	6	379	1	408	4.0e-24	106	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
644855184	445	22.78	16	444	3	419	3.0e-28	119	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
644855185	472	45.63	1	412	1	405	2.0e-119	422	COG4393	Uncharacterized membrane protein	405
644855186	173	73.14	1	172	3	177	4.0e-74	270	COG3470	Uncharacterized protein probably involved in high-affinity Fe2+ transport	179
644855187	635	34.7	219	629	1	383	3.0e-77	283	COG0672	High-affinity Fe2+/Pb2+ permease	383
644855188	235	42.98	4	231	2	217	2.0e-55	209	COG1556	L-lactate utilization protein LutC, contains LUD domain	218
644855190	532	35.83	1	529	4	520	4.0e-115	408	COG1620	L-lactate permease	522
644855192	797	36.49	123	772	30	661	0.0e+00	560	COG0744	Membrane carboxypeptidase (penicillin-binding protein)	661
644855193	120	46.28	1	120	1	120	1.0e-31	128	COG3112	Uncharacterized protein YacL, UPF0231 family	121
644855194	113	54.21	7	113	4	110	4.0e-39	153	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
644855195	267	54.3	1	254	1	255	1.0e-95	342	COG0024	Methionine aminopeptidase	255
644855196	866	46.67	1	866	1	862	0.0e+00	970	COG2844	UTP:GlnB (protein PII) uridylyltransferase	867
644855197	427	65.42	1	427	4	430	0.0e+00	667	COG0001	Glutamate-1-semialdehyde aminotransferase	432
644855198	357	29.02	1	307	5	311	1.0e-40	160	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
644855207	150	35.97	6	144	3	140	8.0e-29	119	COG3787	Uncharacterized conserved protein YhbP, UPF0306 family	145
644855208	270	57.25	1	262	2	263	4.0e-114	404	COG4167	ABC-type antimicrobial peptide transport system, ATPase component	267
644855209	350	65.86	1	331	1	330	0.0e+00	576	COG4170	ABC-type antimicrobial peptide transport system, ATPase component	330
644855210	295	53.56	1	295	2	296	5.0e-111	394	COG4171	ABC-type antimicrobial peptide transport system, permease component	296
644855211	322	44.86	2	322	1	320	2.0e-110	392	COG4168	ABC-type antimicrobial peptide transport system, permease component	321
644855214	241	24.69	3	240	31	256	3.0e-27	115	COG0725	ABC-type molybdate transport system, periplasmic component	258
644855215	468	56.62	1	468	1	466	0.0e+00	672	COG3106	Predicted ATPase, YcjX-like family	467
644855216	364	43.03	19	353	16	343	3.0e-102	365	COG3768	Uncharacterized membrane protein YcjF, UPF0283 family	350
644855218	423	49.02	2	409	6	406	5.0e-123	434	COG2262	50S ribosomal subunit-associated GTPase HflX	411
644855220	100	69.74	1	75	1	76	8.0e-24	101	COG1923	sRNA-binding regulator protein Hfq	77
644855221	318	53.38	8	302	2	294	6.0e-105	374	COG0324	tRNA A37 N6-isopentenylltransferase MiaA	308
644855222	615	42.27	2	567	3	583	0.0e+00	567	COG0323	DNA mismatch repair ATPase MutL	638
644855223	485	36.56	18	244	44	231	1.0e-48	187	COG0860	N-acetylmuramoyl-L-alanine amidase	231
644855224	144	50	1	143	11	149	3.0e-42	163	COG0802	tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE	149
644855228	181	73.48	1	181	1	181	1.0e-85	309	COG1949	Oligoribonuclease (3'-5' exoribonuclease)	184
644855229	346	40.95	29	343	1	301	9.0e-98	350	COG1162	Putative ribosome biogenesis GTPase RsgA	301
644855230	85	51.85	1	81	1	81	2.0e-22	97.2	COG1925	Phosphotransferase system, HPr and related phosphotransfer proteins	88
644855231	575	60.38	1	573	2	574	0.0e+00	812	COG1080	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)	574
644855232	166	55.77	13	166	1	156	5.0e-47	180	COG2190	Phosphotransferase system IIA component	156
644855233	679	57.27	1	679	8	683	0.0e+00	956	COG0339	Zn-dependent oligopeptidase	683
644855234	121	40.18	1	112	2	113	1.0e-20	92.2	COG2832	Uncharacterized membrane protein YbaN, DUF454 family	119
644855235	471	31.51	2	469	32	561	2.0e-74	273	COG4166	ABC-type oligopeptide transport system, periplasmic component	562
644855238	217	64.43	3	196	2	193	6.0e-76	277	COG0807	GTP cyclohydrolase II	193
644855239	219	19.59	1	181	6	198	8.0e-06	44	COG0671	Membrane-associated phospholipid phosphatase	232
644855240	304	33.44	1	304	7	308	1.0e-53	203	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
644855242	375	35.4	56	375	41	341	6.0e-73	268	COG2951	Membrane-bound lytic murein transglycosylase B	343
644855243	262	36.03	16	262	18	263	5.0e-38	151	COG1682	ABC-type polysaccharide/polyol phosphate export permease	263
644855244	247	51.67	5	244	1	240	6.0e-77	280	COG1134	ABC-type polysaccharide/polyol phosphate transport system, ATPase component	249
644855245	118	20.93	1	117	9	136	1.0e-05	41.8	COG2246	Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose)	139
644855248	582	16.3	150	408	4	270	3.0e-06	47.4	COG1216	Glycosyltransferase, GT2 family	305
644855249	383	53.89	1	367	1	373	0.0e+00	499	COG0562	UDP-galactopyranose mutase	374
644855250	307	26.13	4	307	3	298	9.0e-36	144	COG1216	Glycosyltransferase, GT2 family	305
644855252	470	44.17	233	470	1	226	8.0e-68	251	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
644855253	267	44.98	1	267	1	260	7.0e-87	313	COG0708	Exonuclease III	261
644855255	349	62.57	1	333	1	319	0.0e+00	519	COG1088	dTDP-D-glucose 4,6-dehydratase	340
644855258	184	30.54	1	184	3	205	3.0e-16	78.5	COG0778	Nitroreductase	207
644855259	628	38.28	272	573	4	305	9.0e-62	231	COG0616	Periplasmic serine protease, ClpP class	317
644855260	374	24.3	96	353	1	279	1.0e-48	187	COG0287	Prephenate dehydrogenase	279
644855261	207	47.09	2	206	1	204	8.0e-63	233	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
644855263	254	44.8	2	217	32	248	3.0e-60	225	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
644855264	323	27.67	1	297	1	294	5.0e-38	152	COG0583	DNA-binding transcriptional regulator, LysR family	297
644855265	137	42.02	25	137	10	124	1.0e-30	125	COG2351	5-hydroxyisourate hydrolase (purine catabolism), transthyretin-related family	124
644855266	285	57.29	1	96	4	99	2.0e-37	149	COG3615	Uncharacterized protein/domain, possibly involved in tellurite resistance	99
644855267	885	72.3	1	885	1	887	0.0e+00	1456	COG2609	Pyruvate dehydrogenase complex, dehydrogenase (E1) component	887
644855268	626	43.02	199	626	1	403	4.0e-101	362	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	404
644855269	474	53.17	3	456	1	454	0.0e+00	498	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
644855271	198	19.65	3	198	29	256	1.0e-16	80.1	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
644855272	325	25.72	4	323	113	452	5.0e-60	224	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
644855273	188	42.63	1	187	2	190	1.0e-56	212	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
644855274	314	40.5	1	314	1	316	3.0e-82	298	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
644855275	648	25.94	1	648	1	608	2.0e-63	237	COG4206	Outer membrane cobalamin receptor protein	608
644855277	160	23.94	19	155	7	136	3.0e-10	58.3	COG1943	REP element-mobilizing transposase RayT	136
644855278	325	37.65	3	322	1	332	2.0e-41	162	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
644855279	249	38.59	1	230	2	242	6.0e-55	207	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
644855285	1229	58.88	326	1198	1	842	0.0e+00	1178	COG1410	Methionine synthase I, cobalamin-binding domain	842
644855286	394	38.69	1	394	1	408	6.0e-89	321	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
644855287	235	50	12	234	1	224	4.0e-78	284	COG1136	ABC-type lipoprotein export system, ATPase component	226
644855288	416	39.23	1	415	3	407	3.0e-103	368	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
644855289	466	49.55	16	457	1	434	0.0e+00	544	COG0305	Replicative DNA helicase	435
644855290	360	50.69	2	360	1	360	2.0e-127	448	COG0787	Alanine racemase	360
644855291	549	52.54	49	539	4	446	0.0e+00	554	COG0166	Glucose-6-phosphate isomerase	446
644855292	157	62.09	1	153	1	152	3.0e-52	197	COG0054	6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)	152
644855293	141	47.55	6	141	5	147	1.0e-35	142	COG0781	Transcription termination factor NusB	151
644855294	331	47.29	1	330	1	317	5.0e-97	348	COG0611	Thiamine monophosphate kinase	317
644855295	163	41.94	7	159	7	159	9.0e-30	123	COG1267	Phosphatidylglycerophosphatase A	160
644855296	207	28.29	1	202	6	208	3.0e-23	101	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
644855297	270	57.3	1	267	1	266	8.0e-99	353	COG0289	Dihydrodipicolinate reductase	266
644855299	461	28.54	12	461	4	457	1.0e-45	177	COG0471	Di- and tricarboxylate transporter	461
644855300	376	36.27	2	372	1	347	5.0e-92	331	COG0208	Ribonucleotide reductase beta subunit, ferritin-like domain	348
644855302	756	36.62	41	755	1	654	0.0e+00	611	COG0209	Ribonucleotide reductase alpha subunit	696
644855304	342	38.49	43	341	1	299	6.0e-61	228	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
644855305	674	32.71	129	663	6	530	1.0e-83	304	COG1178	ABC-type Fe3+ transport system, permease component	540
644855306	328	45.37	2	309	21	333	8.0e-101	360	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
644855308	209	45.75	1	207	1	209	1.0e-59	222	COG3955	Uncharacterized protein, DUF1919 family	211
644855309	160	23.33	26	143	14	125	1.0e-06	46	COG0526	Thiol-disulfide isomerase or thioredoxin	127
644855310	213	42.65	6	208	11	220	1.0e-28	119	COG0785	Cytochrome c biogenesis protein CcdA	220
644855311	356	48.85	40	209	1	174	7.0e-61	228	COG0225	Peptide methionine sulfoxide reductase MsrA	174
644855311	356	64.44	211	345	1	135	2.0e-62	232	COG0229	Peptide methionine sulfoxide reductase MsrB	140
644855312	230	44.93	1	203	1	207	3.0e-58	218	COG0288	Carbonic anhydrase	207
644855313	195	45.79	7	195	8	196	3.0e-45	175	COG2823	Osmotically-inducible protein OsmY, contains BON domain	196
644855314	194	39.66	1	179	1	176	5.0e-48	183	COG0279	Phosphoheptose isomerase	176
644855315	119	46.96	5	119	1	113	3.0e-32	130	COG0792	Predicted endonuclease distantly related to archaeal Holliday junction resolvase	114
644855316	571	43.82	1	570	2	603	0.0e+00	571	COG3107	Outer membrane lipoprotein LpoA, binds and activates PBP1a	604
644855317	280	52.52	2	279	1	273	3.0e-102	364	COG0313	16S rRNA C1402 (ribose-2'-O) methylase RsmI	275
644855318	499	68.34	1	499	2	499	0.0e+00	830	COG0554	Glycerol kinase	499
644855319	264	47.45	4	255	1	241	1.0e-51	196	COG0580	Glycerol uptake facilitator and related aquaporins (Major Intrinsic Protein Family)	241
644855320	530	35.34	14	522	11	532	4.0e-119	422	COG0578	Glycerol-3-phosphate dehydrogenase	532
644855321	196	45.54	1	193	1	202	2.0e-60	225	COG1182	FMN-dependent NADH-azoreductase	202
644855322	353	33.02	42	345	8	309	1.0e-58	220	COG0616	Periplasmic serine protease, ClpP class	317
644855324	291	51.05	1	286	1	285	3.0e-104	371	COG3001	Fructosamine-3-kinase	286
644855326	643	55.26	34	640	1	588	0.0e+00	813	COG0441	Threonyl-tRNA synthetase	589
644855327	159	66.67	1	159	18	175	5.0e-59	220	COG0290	Translation initiation factor IF-3	176
644855328	65	61.54	1	65	1	65	2.0e-10	57.2	COG0291	Ribosomal protein L35	65
644855329	117	80.34	1	117	1	117	3.0e-39	153	COG0292	Ribosomal protein L20	118
644855332	619	64.32	3	616	1	624	0.0e+00	957	COG1154	Deoxyxylulose-5-phosphate synthase	627
644855333	296	41.74	3	296	2	322	7.0e-63	234	COG0142	Geranylgeranyl pyrophosphate synthase	322
644855334	81	46.15	4	81	3	80	1.0e-07	48.4	COG1722	Exonuclease VII small subunit	81
644855336	217	36.46	29	217	2	188	4.0e-35	141	COG2819	Predicted hydrolase of the alpha/beta superfamily	264
644855337	298	66.32	1	289	1	291	2.0e-126	445	COG0777	Acetyl-CoA carboxylase beta subunit	294
644855338	448	40.53	5	448	1	423	7.0e-118	417	COG0285	Folylpolyglutamate synthase/Dihydropteroate synthase	427
644855339	213	30.57	5	193	3	189	5.0e-35	141	COG0406	Broad specificity phosphatase PhoE	208
644855340	485	34.51	46	485	1	438	7.0e-73	268	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
644855341	302	45.48	1	299	1	297	4.0e-67	248	COG2431	Uncharacterized membrane protein YbjE, DUF340 family	297
644855342	238	36.45	1	198	76	289	5.0e-45	174	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
644855344	107	64.29	1	107	1	112	8.0e-38	148	COG2824	Uncharacterized Zn-ribbon-containing protein	112
644855347	605	54.89	1	182	37	220	1.0e-66	248	COG1136	ABC-type lipoprotein export system, ATPase component	226
644855348	394	24.74	6	387	15	364	2.0e-29	123	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
644855349	559	36.15	30	538	1	472	3.0e-114	405	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	472
644855350	159	53.02	12	159	4	150	4.0e-52	197	COG2983	Uncharacterized cysteine cluster protein YcgN, CxxCxxCC family	153
644855351	730	59.4	100	727	1	628	0.0e+00	832	COG0296	1,4-alpha-glucan branching enzyme	628
644855352	686	47.56	11	685	1	691	0.0e+00	749	COG1523	Pullulanase/glycogen debranching enzyme	697
644855353	436	49.52	14	428	2	393	0.0e+00	519	COG0448	ADP-glucose pyrophosphorylase	393
644855354	479	49.08	1	479	1	481	0.0e+00	520	COG0297	Glycogen synthase	487
644855355	821	50	15	816	2	750	0.0e+00	908	COG0058	Glucan phosphorylase	750
644855357	201	27.86	1	201	8	207	1.0e-31	130	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
644855358	95	54.84	2	94	1	92	1.0e-27	114	COG1825	Ribosomal protein L25 (general stress protein Ctc)	93
644855361	440	69.32	1	440	1	440	0.0e+00	731	COG3006	Chromosome condensin MukBEF complex, kleisin-like MukF subunit	440
644855363	1153	32.4	617	1139	8	519	7.0e-80	293	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
644855364	248	67.38	7	239	6	237	8.0e-103	366	COG3095	Chromosome condensin MukBEF, MukE localization factor	238
644855365	1497	70.24	29	1497	1	1471	0.0e+00	2175	COG3096	Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655	1480
644855367	464	59.61	6	463	19	475	0.0e+00	715	COG2925	Exonuclease I	475
644855368	161	57.14	1	161	1	161	3.0e-57	214	COG1528	Ferritin	167
644855369	166	60.12	1	163	1	163	6.0e-57	213	COG1528	Ferritin	167
644855371	257	35.44	34	238	7	212	6.0e-39	154	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
644855372	310	25.32	154	305	3	152	8.0e-13	68.1	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
644855373	278	32.96	1	263	1	264	9.0e-58	217	COG5266	Uncharacterized conserved protein, contains GH25 family domain	264
644855374	868	45.87	3	600	1	570	0.0e+00	665	COG0550	DNA topoisomerase IA	570
644855375	302	28.67	4	290	3	289	4.0e-39	155	COG0583	DNA-binding transcriptional regulator, LysR family	297
644855376	275	45.91	1	256	1	254	4.0e-63	234	COG0613	Predicted metal-dependent phosphoesterase TrpH, contains PHP domain	258
644855379	339	43.77	50	339	5	289	6.0e-85	307	COG0167	Dihydroorotate dehydrogenase	310
644855380	869	41.27	3	863	9	859	0.0e+00	703	COG0308	Aminopeptidase N	859
644855381	165	60.87	5	165	2	160	2.0e-61	228	COG0041	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	162
644855382	362	39.37	7	357	1	375	1.0e-116	413	COG0026	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	375
644855383	396	62.12	1	396	1	396	0.0e+00	628	COG1448	Aspartate/tyrosine/aromatic aminotransferase	396
644855384	328	44.04	6	325	6	330	5.0e-50	191	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
644855385	262	39	1	257	2	253	4.0e-62	231	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
644855386	371	30.03	49	336	32	319	3.0e-38	152	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
644855387	69	59.42	1	69	1	69	3.0e-15	73.4	COG3585	Molybdopterin-binding protein	69
644855389	185	19.64	1	159	3	170	2.0e-09	55.8	COG1309	DNA-binding transcriptional regulator, AcrR family	201
644855390	326	24.72	2	246	14	273	2.0e-17	83.5	COG1566	Multidrug resistance efflux pump	352
644855391	375	22.07	161	373	74	285	5.0e-10	59.2	COG0842	ABC-type multidrug transport system, permease component	286
644855392	470	28.45	14	470	1	448	4.0e-53	202	COG1538	Outer membrane protein TolC	457
644855393	363	30.62	154	362	2	190	5.0e-29	122	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
644855394	138	30.16	14	137	12	135	5.0e-06	43.8	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
644855395	322	34.77	29	281	1	249	9.0e-55	207	COG0037	tRNA(Ile)-lysidine synthase TilS/MesJ	298
644855397	98	48.94	2	95	1	94	2.0e-25	107	COG0776	Bacterial nucleoid DNA-binding protein	94
644855398	796	45.74	143	795	1	650	0.0e+00	685	COG0072	Phenylalanyl-tRNA synthetase beta subunit	650
644855399	329	54.79	1	327	3	335	2.0e-124	438	COG0016	Phenylalanyl-tRNA synthetase alpha subunit	335
644855400	288	31.85	2	288	22	296	3.0e-43	168	COG0501	Zn-dependent protease with chaperone function	302
644855404	324	55.45	16	216	1	202	3.0e-69	255	COG0794	D-arabinose 5-phosphate isomerase GutQ	202
644855405	184	50.29	5	177	1	170	3.0e-59	221	COG1778	 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases	170
644855406	515	37.8	13	511	7	459	3.0e-130	459	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
644855407	194	51.55	1	190	1	191	2.0e-66	244	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
644855409	333	50.15	1	333	2	335	9.0e-110	390	COG0547	Anthranilate phosphoribosyltransferase	338
644855410	476	51.35	16	272	1	254	3.0e-87	316	COG0134	Indole-3-glycerol phosphate synthase	254
644855411	388	51.31	14	356	13	342	7.0e-114	404	COG1740	Ni,Fe-hydrogenase I small subunit	355
644855412	346	30.67	31	255	5	198	2.0e-39	156	COG0437	Fe-S-cluster-containing dehydrogenase component	203
644855413	408	47.75	3	391	4	397	1.0e-79	290	COG5557	Ni/Fe-hydrogenase 2 integral membrane subunit HybB	401
644855414	569	52.99	4	569	1	545	0.0e+00	655	COG0374	Ni,Fe-hydrogenase I large subunit	545
644855415	159	35.9	1	154	2	157	1.0e-28	119	COG0680	Ni,Fe-hydrogenase maturation factor	160
644855417	91	55.56	1	81	1	77	2.0e-20	90.7	COG0298	Hydrogenase maturation factor	82
644855420	89	48.24	2	86	1	81	6.0e-18	82.3	COG3630	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit	84
644855421	598	61.92	1	476	2	472	0.0e+00	722	COG5016	Pyruvate/oxaloacetate carboxyltransferase	472
644855422	436	70.77	1	431	1	375	0.0e+00	495	COG1883	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit	375
644855423	250	58.51	3	242	7	246	9.0e-88	316	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
644855424	399	68.61	2	396	1	394	0.0e+00	698	COG0133	Tryptophan synthase beta chain	396
644855425	268	45.15	1	268	1	264	2.0e-86	312	COG0159	Tryptophan synthase alpha chain	265
644855426	562	23.99	29	561	110	654	6.0e-66	245	COG0209	Ribonucleotide reductase alpha subunit	696
644855427	329	24.84	11	318	24	334	2.0e-24	106	COG0208	Ribonucleotide reductase beta subunit, ferritin-like domain	348
644855428	500	48.86	23	499	1	477	0.0e+00	568	COG0469	Pyruvate kinase	477
644855429	102	32.61	1	92	3	94	7.0e-18	82.3	COG1359	Quinol monooxygenase YgiN	100
644855430	292	41.89	28	281	1	265	6.0e-76	277	COG1830	Fructose-bisphosphate aldolase class Ia, DhnA family	265
644855431	338	28.93	8	285	16	294	2.0e-41	163	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
644855432	334	33.44	1	308	1	304	6.0e-46	178	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
644855433	342	38.91	5	311	1	310	3.0e-51	196	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
644855434	505	41.88	4	502	1	500	0.0e+00	526	COG1129	ABC-type sugar transport system, ATPase component	500
644855435	321	41.51	13	320	7	320	2.0e-80	292	COG2390	DNA-binding transcriptional regulator LsrR, DeoR family	321
644855436	242	46.96	1	227	2	216	2.0e-60	225	COG0132	Dethiobiotin synthetase	223
644855437	467	48.3	1	467	1	435	0.0e+00	550	COG0017	Aspartyl/asparaginyl-tRNA synthetase	435
644855438	147	49.03	1	147	1	155	1.0e-55	208	COG2969	Stringent starvation protein B	155
644855439	213	34.33	11	198	1	199	3.0e-34	138	COG0625	Glutathione S-transferase	211
644855440	151	46.98	1	149	1	149	3.0e-47	180	COG0314	Molybdopterin synthase catalytic subunit	149
644855441	81	41.67	1	81	1	84	2.0e-16	77.7	COG1977	Molybdopterin converting factor, small subunit	84
644855442	162	67.72	1	158	1	157	3.0e-64	237	COG0315	Molybdenum cofactor biosynthesis enzyme	157
644855443	337	46.15	13	337	1	322	5.0e-109	387	COG2896	Molybdenum cofactor biosynthesis enzyme MoaA	322
644855444	324	38.98	11	313	2	314	1.0e-70	260	COG0391	Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family	323
644855445	234	46.79	3	212	2	218	1.0e-65	242	COG3340	Peptidase E	224
644855446	207	25.13	21	204	8	192	4.0e-19	88.1	COG3381	Cytoplasmic chaperone TorD involved in molybdoenzyme TorA maturation	204
644855447	819	30.07	4	802	3	764	0.0e+00	503	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
644855448	391	52.51	4	182	3	181	2.0e-65	243	COG3005	Tetraheme cytochrome c subunit of nitrate or TMAO reductase	190
644855450	482	40.16	1	384	2	383	7.0e-106	378	COG0301	Adenylyl- and sulfurtransferase ThiI, participates in tRNA 4-thiouridine and thiamine biosynthesis	383
644855451	365	47.46	2	176	12	188	8.0e-57	214	COG3005	Tetraheme cytochrome c subunit of nitrate or TMAO reductase	190
644855452	826	33	7	809	1	764	0.0e+00	579	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
644855453	258	30.3	5	132	1	118	2.0e-19	89.6	COG2315	Predicted DNA-binding protein with ?double-wing? structural motif, MmcQ/YjbR family	118
644855455	541	42.23	10	508	1	492	3.0e-105	376	COG0366	Glycosidase	505
644855456	472	29.61	98	467	1	378	1.0e-66	247	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
644855457	261	50.96	1	261	2	262	5.0e-96	344	COG0101	tRNA U38,U39,U40 pseudouridine synthase TruA	266
644855458	130	66.92	1	130	1	130	1.0e-47	181	COG0103	Ribosomal protein S9	130
644855459	142	63.64	1	142	1	143	4.0e-57	213	COG0102	Ribosomal protein L13	148
644855461	659	26.26	1	658	32	693	1.0e-93	337	COG0507	ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I	696
644855462	1220	31.14	1	1192	5	1139	0.0e+00	688	COG1074	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)	1139
644855463	118	34.38	2	118	1	126	7.0e-26	109	COG1553	Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family	126
644855464	436	57.14	4	436	3	436	5.0e-122	431	COG2252	Xanthine/uracil/vitamin C permease, AzgA family	436
644855466	176	35.44	17	172	1	147	4.0e-36	144	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
644855467	591	40.41	14	578	72	646	0.0e+00	488	COG1067	Predicted ATP-dependent protease	647
644855468	148	60.14	1	148	1	148	9.0e-48	182	COG3120	Macrodomain Ter protein organizer, MatP/YcbG family	149
644855469	69	49.25	1	67	1	67	3.0e-20	90.2	COG1278	Cold shock protein, CspA family	67
644855470	53	64	2	51	1	50	1.0e-09	54.7	COG3140	Uncharacterized conserved protein YoaH, UPF0181 family	60
644855471	236	38.05	2	224	78	288	1.0e-52	199	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
644855472	105	50.49	1	102	3	105	4.0e-25	106	COG3098	Uncharacterized conserved protein YqcC, DUF446 family	109
644855473	260	56.32	1	260	1	256	4.0e-93	334	COG5595	Predicted  nucleic acid-binding protein, contains Zn-ribbon domain	256
644855474	279	60.58	1	136	1	137	4.0e-52	198	COG2904	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF, N-terminal domain	137
644855475	180	51.96	3	180	1	178	2.0e-75	274	COG3101	Elongation factor P hydroxylase (EF-P beta-lysylation pathway)	180
644855476	649	58.17	9	602	1	596	0.0e+00	781	COG0465	ATP-dependent Zn proteases	596
644855477	209	58.91	7	208	1	202	2.0e-74	271	COG0293	23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ	205
644855478	278	49.47	2	278	5	286	1.0e-111	396	COG0788	Formyltetrahydrofolate hydrolase	287
644855479	132	50.39	7	132	1	127	4.0e-23	100	COG2916	DNA-binding protein H-NS	128
644855480	509	37.4	6	503	1	481	2.0e-72	267	COG1757	Na+/H+ antiporter NhaC	485
644855483	330	30.54	1	325	1	330	2.0e-59	223	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
644855484	237	51.11	14	233	10	234	3.0e-76	278	COG2949	Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin	235
644855485	341	51.04	1	334	38	368	2.0e-124	438	COG2021	Homoserine acetyltransferase	368
644855487	341	47.43	2	330	1	330	6.0e-101	360	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
644855488	879	55.1	4	879	5	910	0.0e+00	1192	COG2352	Phosphoenolpyruvate carboxylase	910
644855489	106	63.55	1	106	2	108	2.0e-35	140	COG3099	Uncharacterized conserved protein YciU, UPF0263 family	108
644855490	581	38.67	13	581	1	586	0.0e+00	559	COG4178	ABC-type uncharacterized transport system, permease and ATPase components	604
644855491	743	27.17	5	743	13	768	2.0e-59	224	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
644855492	465	33.19	7	460	10	454	5.0e-73	269	COG0534	Na+-driven multidrug efflux pump	455
644855493	204	47.06	1	204	1	197	1.0e-69	255	COG0307	Riboflavin synthase alpha chain	204
644855494	100	55.67	4	99	1	97	2.0e-27	113	COG1534	RNA-binding protein YhbY	97
644855495	158	53.95	6	157	1	150	3.0e-44	170	COG0782	Transcription elongation factor, GreA/GreB family	151
644855496	480	40.84	10	480	6	470	1.0e-127	450	COG2027	D-alanyl-D-alanine carboxypeptidase	470
644855497	218	44.04	28	218	5	194	2.0e-63	235	COG0302	GTP cyclohydrolase I	195
644855498	404	43.67	1	402	6	404	0.0e+00	464	COG0303	Molybdopterin biosynthesis enzyme	404
644855499	243	50.83	1	237	1	242	1.0e-66	246	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
644855501	427	47.26	8	427	11	429	6.0e-104	371	COG4580	Maltoporin (phage lambda and maltose receptor)	429
644855502	436	21.06	24	405	1	501	1.0e-28	121	COG0366	Glycosidase	505
644855503	372	54.32	1	359	1	338	1.0e-124	439	COG3839	ABC-type sugar transport system, ATPase component	338
644855504	401	37.5	1	401	1	416	1.0e-94	340	COG2182	Maltose-binding periplasmic protein MalE	420
644855505	396	38.07	8	395	20	413	1.0e-103	370	COG2182	Maltose-binding periplasmic protein MalE	420
644855506	515	38.82	260	513	52	290	4.0e-50	192	COG1175	ABC-type sugar transport system, permease component	295
644855507	296	53.51	1	296	1	282	3.0e-82	298	COG3833	ABC-type maltose transport system, permease component	282
644855508	683	23.1	189	679	1	480	6.0e-42	166	COG0366	Glycosidase	505
644855526	905	43.15	1	903	6	894	0.0e+00	699	COG2909	ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT	894
644855527	796	47.25	25	793	23	746	0.0e+00	782	COG0058	Glucan phosphorylase	750
644855528	691	39.43	132	691	1	518	0.0e+00	491	COG1640	4-alpha-glucanotransferase	520
644855529	587	24.75	138	559	1	494	2.0e-55	210	COG0366	Glycosidase	505
644855530	193	55.21	4	193	2	190	1.0e-72	265	COG0163	3-polyprenyl-4-hydroxybenzoate decarboxylase	191
644855531	503	52.56	1	484	4	470	0.0e+00	628	COG0034	Glutamine phosphoribosylpyrophosphate amidotransferase	470
644855532	185	47.24	1	162	3	165	1.0e-30	126	COG1286	Uncharacterized membrane protein, required for colicin V production	182
644855533	148	53.06	2	148	7	149	3.0e-41	160	COG3092	Uncharacterized membrane protein YfbV, UPF0208 family	149
644855534	444	54.27	48	443	1	393	0.0e+00	555	COG0282	Acetate kinase	396
644855535	711	46.6	1	380	1	354	5.0e-97	349	COG0857	BioD-like N-terminal domain of phosphotransacetylase	354
644855535	711	54.29	391	711	1	325	1.0e-115	410	COG0280	Phosphotransacetylase	327
644855537	452	35.14	7	448	5	440	1.0e-104	373	COG2271	Sugar phosphate permease	448
644855538	168	51.88	1	160	1	160	9.0e-53	199	COG0801	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	160
644855539	421	36.84	1	410	6	412	4.0e-87	315	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
644855541	145	54.17	26	145	1	120	7.0e-31	126	COG1734	RNA polymerase-binding transcription factor DksA	120
644855543	755	40.07	485	745	32	293	2.0e-66	247	COG2333	Metal-dependent hydrolase, beta-lactamase superfamily II	293
644855544	582	41.11	9	582	1	567	0.0e+00	481	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
644855545	325	47.59	1	323	6	334	4.0e-103	368	COG1663	Tetraacyldisaccharide-1-P 4'-kinase	336
644855546	59	55.93	1	59	1	59	5.0e-15	72.9	COG2835	Uncharacterized conserved protein YbaR, Trm112 family	60
644855547	257	61.42	1	254	1	244	9.0e-102	363	COG1212	CMP-2-keto-3-deoxyoctulosonic acid synthetase	247
644855548	612	51.64	4	610	1	581	0.0e+00	660	COG0322	Excinuclease UvrABC, nuclease subunit	581
644855549	444	24.42	23	443	1	415	4.0e-42	166	COG1914	Mn2+ and Fe2+ transporters of the NRAMP family	416
644855550	336	29.55	7	336	1	329	9.0e-64	237	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
644855553	363	26.16	6	333	3	335	1.0e-50	194	COG4134	ABC-type uncharacterized transport system YnjBCD, periplasmic component	384
644855554	283	30.8	10	272	3	260	2.0e-41	162	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
644855555	285	21.95	1	282	2	286	6.0e-32	131	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
644855556	356	44.07	1	353	3	351	2.0e-107	382	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
644855557	318	64.63	1	310	30	340	8.0e-122	430	COG0709	Selenophosphate synthase	346
644855558	474	57.53	1	474	1	463	0.0e+00	653	COG1282	NAD/NADP transhydrogenase beta subunit	463
644855559	510	64.19	3	365	2	356	0.0e+00	469	COG3288	NAD/NADP transhydrogenase alpha subunit	356
644855561	240	48.74	1	238	2	228	2.0e-79	288	COG1489	DNA-binding protein, stimulates sugar fermentation	235
644855562	395	47.15	4	395	2	401	1.0e-121	430	COG0162	Tyrosyl-tRNA synthetase	401
644855563	308	34.78	4	308	1	309	2.0e-54	206	COG0524	Sugar or nucleoside kinase, ribokinase family	311
644855564	484	37.71	9	466	5	467	6.0e-111	394	COG1621	Sucrose-6-phosphate hydrolase SacC, GH32 family	486
644855566	306	41.25	5	304	5	270	1.0e-73	269	COG0130	tRNA U55 pseudouridine synthase TruB, may also work on U342 of tmRNA	271
644855567	128	50	7	120	6	118	3.0e-30	124	COG0858	Ribosome-binding factor A	118
644855568	627	64.5	124	627	1	507	0.0e+00	686	COG0532	Translation initiation factor IF-2, a GTPase	509
644855570	498	48.47	161	355	1	190	3.0e-49	189	COG0195	Transcription antitermination factor NusA, contains S1 and KH domains	190
644855571	151	47.68	1	151	3	153	3.0e-49	187	COG0779	Ribosome maturation factor RimP	153
644855574	83	60.24	1	83	11	93	7.0e-28	115	COG3100	Uncharacterized conserved protein YcgL, UPF0745 family	103
644855575	220	31.48	6	219	1	216	3.0e-39	155	COG0850	Septum formation inhibitor MinC	219
644855577	155	32.89	1	148	2	149	3.0e-31	128	COG2062	Phosphohistidine phosphatase SixA	163
644855578	445	46.29	1	443	4	459	9.0e-119	420	COG1109	Phosphomannomutase	464
644855579	275	51.14	15	275	8	267	1.0e-79	289	COG0294	Dihydropteroate synthase	274
644855580	301	32.99	5	291	6	288	6.0e-51	194	COG2962	Uncharacterized membrane protein RarD, contains two EamA domains	293
644855581	153	32.45	1	151	3	152	2.0e-27	114	COG1522	DNA-binding transcriptional regulator, Lrp family	154
644855582	360	42.78	10	359	1	354	9.0e-98	350	COG0389	Nucleotidyltransferase/DNA polymerase involved in DNA repair	354
644855584	415	68.13	1	411	2	404	0.0e+00	553	COG3633	Na+/serine symporter	407
644855587	256	29.2	32	256	20	229	3.0e-17	82.3	COG2801	Transposase InsO and inactivated derivatives	232
644855589	284	64.41	2	282	1	279	0.0e+00	476	COG2877	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase	279
644855590	299	41.14	1	297	1	280	2.0e-72	266	COG2890	Methylase of polypeptide chain release factors	280
644855592	360	67.22	1	359	1	363	0.0e+00	565	COG0216	Protein chain release factor A	363
644855593	151	52.82	4	144	6	147	3.0e-34	137	COG3133	Outer membrane lipoprotein SlyB	154
644855596	577	42.56	1	577	1	577	0.0e+00	621	COG0018	Arginyl-tRNA synthetase	577
644855597	477	24.8	3	473	1	479	7.0e-53	202	COG5339	Uncharacterized conserved protein YdgA, DUF945 family	479
644855598	633	61.55	1	605	4	579	0.0e+00	674	COG0443	Molecular chaperone DnaK (HSP70)	579
644855600	374	61.97	1	371	1	371	0.0e+00	501	COG0484	DnaJ-class molecular chaperone with C-terminal Zn finger domain	371
644855601	347	23.37	1	347	1	354	2.0e-37	150	COG3203	Outer membrane protein (porin)	354
644855602	395	38.04	4	395	6	396	4.0e-121	428	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
644855603	185	41.53	1	182	10	191	5.0e-26	110	COG0558	Phosphatidylglycerophosphate synthase	192
644855606	277	28.4	9	247	1	233	2.0e-24	106	COG1192	Cellulose biosynthesis protein BcsQ	259
644855607	435	37.3	1	428	14	434	2.0e-101	363	COG0305	Replicative DNA helicase	435
644855617	163	40.12	2	148	1	167	2.0e-35	142	COG0629	Single-stranded DNA-binding protein	167
644855621	383	20.68	1	379	3	324	3.0e-34	139	COG0270	Site-specific DNA-cytosine methylase	328
644855626	237	50	4	235	1	232	1.0e-78	286	COG3219	Uncharacterized protein	237
644855627	306	61.76	1	306	2	282	1.0e-109	389	COG3220	Uncharacterized conserved protein, UPF0276 family	282
644855628	95	68.42	1	95	1	95	2.0e-08	50.5	COG3767	Uncharacterized low-complexity protein	95
644855629	146	32.37	1	138	7	142	1.0e-17	82.3	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
644855634	303	21.14	10	298	13	291	7.0e-19	88	COG4974	Site-specific recombinase XerD	300
644855636	275	18.18	17	272	40	301	4.0e-18	85.4	COG3868	Uncharacterized protein	306
644855637	165	27.78	39	162	9	134	5.0e-15	73.8	COG3439	Uncharacterized conserved protein, DUF302 family	137
644855638	140	23.33	1	140	2	181	8.0e-16	76.2	COG3059	Uncharacterized membrane protein YkgB	182
644855639	461	39.61	122	460	1	359	2.0e-99	356	COG1858	Cytochrome c peroxidase	364
644855640	385	44.14	17	381	1	359	2.0e-96	346	COG0349	Ribonuclease D	361
644855641	562	35.61	15	559	3	529	0.0e+00	464	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
644855642	185	32.04	1	180	5	183	3.0e-43	168	COG3065	Starvation-inducible outer membrane lipoprotein	191
644855643	240	36.17	5	235	2	219	1.0e-45	176	COG1214	tRNA A37 threonylcarbamoyladenosine modification protein TsaB	220
644855644	653	41.46	21	653	1	654	0.0e+00	537	COG1199	Rad3-related DNA helicase	654
644855645	274	40.58	9	274	10	281	4.0e-78	284	COG0676	D-hexose-6-phosphate mutarotase	287
644855647	491	37.38	186	486	1	300	4.0e-78	285	COG1732	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)	300
644855648	274	52.06	8	274	1	267	1.0e-94	339	COG1125	ABC-type proline/glycine betaine transport system, ATPase component	309
644855649	286	29.18	1	271	1	275	1.0e-24	106	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
644855650	285	45.64	1	285	19	304	1.0e-74	272	COG3118	Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains	304
644855651	316	54.81	5	314	2	301	6.0e-95	340	COG0492	Thioredoxin reductase	305
644855652	577	53.97	1	577	1	573	0.0e+00	640	COG4987	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components	573
644855653	288	55.59	1	286	2	287	8.0e-109	386	COG1946	Acyl-CoA thioesterase	289
644855660	256	27.61	1	256	3	253	2.0e-31	129	COG3306	Glycosyltransferase involved in LPS biosynthesis, GR25 family	255
644855661	507	16.6	1	487	3	472	5.0e-07	49.7	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
644855662	319	27.86	8	318	13	318	6.0e-48	184	COG5039	Exopolysaccharide biosynthesis protein EpsI, predicted pyruvyl transferase	339
644855663	248	28.19	20	246	6	217	1.0e-25	110	COG1434	Uncharacterized SAM-binding protein YcdF, DUF218 family	223
644855666	515	21.48	3	493	1	476	3.0e-35	143	COG5339	Uncharacterized conserved protein YdgA, DUF945 family	479
644855667	724	46.83	8	656	1	655	0.0e+00	613	COG0210	Superfamily I DNA or RNA helicase	655
644855668	449	42.57	1	449	2	442	1.0e-82	300	COG2610	H+/gluconate symporter or related permease	442
644855669	172	57.5	10	169	1	159	2.0e-66	244	COG3265	Gluconate kinase	161
644855671	332	32.83	7	332	1	329	7.0e-70	257	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
644855672	274	46.56	26	270	19	264	7.0e-84	303	COG1526	Formate dehydrogenase assembly factor FdhD	266
644855675	305	44.09	20	239	1	202	2.0e-59	222	COG0437	Fe-S-cluster-containing dehydrogenase component	203
644855676	237	52.04	10	228	3	218	1.0e-62	233	COG2864	Cytochrome b subunit of formate dehydrogenase	218
644855677	353	61.82	1	351	1	351	0.0e+00	510	COG4148	ABC-type molybdate transport system, ATPase component	352
644855678	242	58.85	11	236	1	225	3.0e-69	255	COG4149	ABC-type molybdate transport system, permease component	225
644855679	254	44.23	1	253	1	256	1.0e-56	213	COG0725	ABC-type molybdate transport system, periplasmic component	258
644855680	259	53.54	5	131	4	130	3.0e-39	155	COG2005	DNA-binding transcriptional regulator ModE (molybdenum-dependent)	130
644855681	198	35.71	4	197	3	192	9.0e-37	146	COG1896	5'-deoxynucleotidase YfbR and related HD superfamily hydrolases	193
644855682	342	38.35	9	337	4	340	1.0e-62	233	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
644855683	374	65.75	4	149	1	146	2.0e-59	222	COG0117	Pyrimidine deaminase domain of riboflavin biosynthesis protein RibD	146
644855684	151	60.26	1	151	1	151	3.0e-60	223	COG1327	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains	156
644855685	362	63.26	1	362	1	355	0.0e+00	559	COG2933	23S rRNA C2498 (ribose-2'-O)-methylase RlmM	358
644855686	297	27.21	6	294	1	294	5.0e-39	154	COG0583	DNA-binding transcriptional regulator, LysR family	297
644855689	339	35.43	30	328	5	284	6.0e-66	244	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
644855690	311	38.2	1	310	1	312	6.0e-71	261	COG0039	Malate/lactate dehydrogenase	313
644855691	155	45.95	7	151	5	150	3.0e-37	148	COG1438	Arginine repressor	150
644855692	294	52.23	3	290	1	290	3.0e-103	368	COG1090	NAD dependent epimerase/dehydratase family enzyme	297
644855694	193	78.76	1	193	1	193	9.0e-69	252	COG4657	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfA subunit	193
644855695	197	58.97	1	192	1	195	1.0e-65	242	COG2878	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit	198
644855696	843	56.9	11	546	1	527	0.0e+00	660	COG4656	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfC subunit	529
644855697	359	57.94	1	359	1	337	2.0e-108	386	COG4658	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfD subunit	338
644855698	203	52.85	5	197	2	193	1.0e-62	232	COG4659	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfG subunit	195
644855699	238	73.68	30	238	2	210	1.0e-85	309	COG4660	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfE subunit	212
644855700	213	57.69	1	208	1	208	2.0e-85	308	COG0177	Endonuclease III	211
644855701	314	43.27	4	314	1	312	5.0e-99	354	COG3958	Transketolase, C-terminal subunit	312
644855702	274	51.46	1	236	5	243	5.0e-86	311	COG3959	Transketolase, N-terminal subunit	243
644855703	89	31.4	1	83	2	87	2.0e-12	64.1	COG3414	Phosphotransferase system, galactitol-specific IIB component	93
644855705	647	45.93	1	533	1	530	0.0e+00	559	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
644855706	450	38.48	6	450	14	408	3.0e-119	422	COG0232	dGTP triphosphohydrolase	412
644855707	230	44.05	1	227	3	229	2.0e-55	208	COG1346	Putative effector of murein hydrolase	230
644855708	136	40	3	127	2	126	3.0e-20	91	COG1380	Putative effector of murein hydrolase LrgA, UPF0299 family	128
644855709	73	40.85	4	73	7	76	8.0e-13	65.3	COG0425	TusA-related sulfurtransferase	78
644855712	166	32.1	16	166	26	186	1.0e-25	109	COG1525	Endonuclease YncB, thermonuclease family	192
644855713	399	43.84	1	397	1	405	8.0e-112	397	COG0520	Selenocysteine lyase/Cysteine desulfurase	405
644855714	126	38.4	2	126	14	138	5.0e-33	133	COG2166	Sulfur transfer protein SufE, Fe-S center assembly	144
644855715	476	59.79	1	475	1	467	0.0e+00	707	COG2870	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase	467
644855716	311	45.48	6	310	3	308	3.0e-93	335	COG1560	Lauroyl/myristoyl acyltransferase	308
644855717	190	38.58	1	183	1	197	1.0e-34	139	COG3381	Cytoplasmic chaperone TorD involved in molybdoenzyme TorA maturation	204
644855718	203	33.69	1	185	1	180	6.0e-42	163	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	189
644855719	150	37.93	5	148	1	140	1.0e-20	92.7	COG1585	Membrane protein implicated in regulation of membrane protease activity	140
644855720	308	44	7	299	2	291	3.0e-55	208	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
644855721	658	37.83	7	574	1	517	2.0e-124	439	COG0737	2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family	517
644855722	741	18.82	5	741	22	768	1.0e-39	158	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
644855723	300	47.2	16	298	35	320	5.0e-78	284	COG4607	ABC-type enterochelin transport system, periplasmic component	320
644855724	321	50.79	5	320	4	320	1.0e-85	310	COG4606	ABC-type enterochelin transport system, permease component	321
644855725	313	49.04	3	313	4	315	7.0e-80	290	COG4605	ABC-type enterochelin transport system, permease component	316
644855726	252	49.4	1	251	1	251	2.0e-93	335	COG4604	ABC-type enterochelin transport system, ATPase component	252
644855730	152	30.77	5	138	5	145	3.0e-18	84.2	COG0680	Ni,Fe-hydrogenase maturation factor	160
644855732	258	59.31	29	173	1	145	1.0e-58	219	COG3260	Ni,Fe-hydrogenase III small subunit	148
644855733	215	33.57	1	135	19	157	4.0e-26	111	COG1143	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)	172
644855734	576	57.37	181	558	4	381	0.0e+00	484	COG3261	Ni,Fe-hydrogenase III large subunit	382
644855735	512	30.85	5	493	9	490	2.0e-51	197	COG0651	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit	504
644855736	212	39.44	2	212	6	218	5.0e-32	131	COG4237	Hydrogenase-4 membrane subunit HyfE	218
644855737	481	38.07	5	477	1	473	4.0e-78	285	COG1009	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit	606
644855738	320	41.69	14	318	6	309	7.0e-54	204	COG0650	Formate hydrogenlyase subunit 4	309
644855739	673	32.87	6	498	3	480	6.0e-67	249	COG0651	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit	504
644855740	199	40.1	1	190	1	155	4.0e-36	144	COG1142	Fe-S-cluster-containing hydrogenase component 2	165
644855741	762	47.71	5	755	2	748	0.0e+00	818	COG0068	Hydrogenase maturation factor HypF (carbamoyltransferase)	750
644855742	271	36.62	1	269	1	282	7.0e-69	254	COG0169	Shikimate 5-dehydrogenase	283
644855746	337	49.71	5	337	3	339	6.0e-96	344	COG0309	Hydrogenase maturation factor	339
644855747	370	55.8	1	370	1	363	0.0e+00	494	COG0409	Hydrogenase maturation factor	364
644855748	268	46.04	68	265	2	196	2.0e-60	225	COG0378	Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase	202
644855749	207	38.68	1	207	1	212	6.0e-47	180	COG1122	Energy-coupling factor transporter ATP-binding protein EcfA2	235
644855750	221	26.7	12	215	14	219	3.0e-10	58.8	COG0619	Energy-coupling factor transporter transmembrane protein EcfT	252
644855751	217	32.18	1	196	1	199	9.0e-22	97.3	COG0310	ABC-type Co2+ transport system, permease component	204
644855753	231	27.59	8	231	7	264	4.0e-31	128	COG5266	Uncharacterized conserved protein, contains GH25 family domain	264
644855754	230	50.22	1	229	3	233	2.0e-61	228	COG0775	Nucleoside phosphorylase	234
644855756	573	43.57	31	548	1	491	1.0e-113	404	COG0608	Single-stranded DNA-specific exonuclease, DHH superfamily, may be involved in archaeal DNA replication intiation	491
644855757	227	27.08	1	227	4	241	5.0e-29	121	COG1651	Protein-disulfide isomerase	244
644855759	289	63.6	52	289	1	239	8.0e-101	360	COG1186	Protein chain release factor B	239
644855760	502	63.17	1	502	1	501	0.0e+00	734	COG1190	Lysyl-tRNA synthetase (class II)	502
644855762	319	30.69	1	315	1	352	7.0e-56	211	COG0484	DnaJ-class molecular chaperone with C-terminal Zn finger domain	371
644855763	509	50.31	1	484	1	444	0.0e+00	579	COG1160	Predicted GTPases	444
644855765	380	37.67	2	376	18	394	9.0e-66	244	COG2814	Predicted arabinose efflux permease, MFS family	394
644855767	194	44.04	1	192	1	183	3.0e-51	194	COG0717	Deoxycytidine triphosphate deaminase	183
644855768	216	54.93	4	216	3	211	7.0e-73	266	COG0572	Uridine kinase	218
644855769	346	44.63	45	345	1	299	4.0e-70	258	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
644855771	344	44.22	47	343	4	299	4.0e-73	268	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
644855772	685	33.15	129	670	1	531	8.0e-97	348	COG1178	ABC-type Fe3+ transport system, permease component	540
644855773	348	46	1	345	1	350	3.0e-116	411	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
644855775	266	48.08	1	258	1	260	1.0e-81	296	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
644855776	244	52.52	1	235	1	234	2.0e-77	282	COG0565	tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase	242
644855777	156	42.07	1	144	1	145	5.0e-38	150	COG1959	DNA-binding transcriptional regulator, IscR family	150
644855778	404	60.87	3	388	1	386	0.0e+00	559	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
644855779	127	50.34	1	126	5	146	4.0e-35	140	COG0822	NifU homolog involved in Fe-S cluster formation	150
644855780	107	61.11	1	107	3	110	2.0e-38	150	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
644855781	174	40.35	4	173	2	172	4.0e-26	111	COG1076	DnaJ-domain-containing proteins 1	174
644855782	619	46.57	19	602	5	579	0.0e+00	548	COG0443	Molecular chaperone DnaK (HSP70)	579
644855783	113	43.4	1	104	1	102	2.0e-17	81.3	COG0633	Ferredoxin	102
644855784	64	73.44	1	64	1	64	2.0e-21	93.9	COG2975	Fe-S-cluster formation regulator IscX/YfhJ	64
644855785	686	43.21	2	547	1	557	0.0e+00	683	COG0143	Methionyl-tRNA synthetase	558
644855786	370	41.79	47	323	1	265	2.0e-63	236	COG0489	Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster	265
644855787	210	43.6	1	209	5	213	4.0e-52	197	COG3683	ABC-type uncharacterized transport system, periplasmic component	213
644855788	340	36.59	4	328	1	301	2.0e-63	236	COG2215	ABC-type nickel/cobalt efflux system, permease component RcnA	303
644855790	697	69.7	24	692	2	659	0.0e+00	1123	COG0556	Excinuclease UvrABC helicase subunit UvrB	663
644855792	460	46.74	6	373	2	347	2.0e-81	296	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
644855793	556	48.43	4	536	1	528	0.0e+00	579	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
644855796	632	47.89	1	630	2	632	0.0e+00	840	COG0187	DNA gyrase/topoisomerase IV, subunit B	635
644855798	750	43.51	8	740	6	740	0.0e+00	789	COG0188	DNA gyrase/topoisomerase IV, subunit A	804
644855800	160	42.31	1	156	1	156	1.0e-43	169	COG0783	DNA-binding ferritin-like protein (oxidative damage protectant)	156
644855801	386	41.25	12	347	8	344	2.0e-92	332	COG1566	Multidrug resistance efflux pump	352
644855803	351	37.75	52	348	1	297	2.0e-57	216	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
644855805	426	30.16	41	407	7	380	3.0e-51	196	COG3550	Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module	392
644855806	954	55.52	7	953	1	877	0.0e+00	1243	COG0525	Valyl-tRNA synthetase	877
644855808	108	75.76	2	100	4	102	4.0e-41	159	COG3097	Uncharacterized protein YqfB, UPF0267 family	106
644855809	148	42.95	2	148	1	141	5.0e-35	140	COG2927	DNA polymerase III, chi subunit	144
644855810	464	70.35	1	462	1	461	0.0e+00	804	COG0114	Fumarate hydratase class II	462
644855812	179	49.47	1	179	1	188	3.0e-62	230	COG3150	Predicted esterase YcpF, UPF0227 family	191
644855813	305	31.66	1	300	1	318	2.0e-60	226	COG0189	Glutathione synthase/RimK-type ligase, ATP-grasp superfamily	318
644855814	244	30.69	11	187	6	207	6.0e-26	111	COG0778	Nitroreductase	207
644855815	86	38.27	1	81	1	76	1.0e-15	75	COG0695	Glutaredoxin	80
644855818	404	38.39	1	399	8	415	2.0e-56	213	COG0814	Amino acid permease	415
644855820	231	42.42	1	231	4	218	5.0e-63	234	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
644855821	286	73.43	1	286	2	287	0.0e+00	501	COG3623	L-ribulose-5-phosphate 3-epimerase UlaE	287
644855822	249	32.54	1	249	1	252	8.0e-50	190	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
644855823	363	22.37	33	336	2	254	1.0e-38	154	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
644855824	591	48.95	1	465	5	481	0.0e+00	492	COG3037	Ascorbate-specific PTS system EIIC-type component UlaA	481
644855825	153	27.27	2	148	1	147	9.0e-22	96.2	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
644855826	224	49.12	1	224	1	216	2.0e-64	239	COG0269	3-keto-L-gulonate-6-phosphate decarboxylase	217
644855828	111	62.75	1	102	1	102	1.0e-26	111	COG2926	Uncharacterized conserved protein YeeX, DUF496 family	109
644855829	360	55.34	1	360	3	365	0.0e+00	483	COG1932	Phosphoserine aminotransferase	365
644855830	365	42.7	6	364	1	353	3.0e-91	329	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
644855831	441	45.58	11	434	9	424	0.0e+00	489	COG0128	5-enolpyruvylshikimate-3-phosphate synthase	428
644855832	343	39.82	8	341	4	305	1.0e-64	240	COG2017	Galactose mutarotase or related enzyme	308
644855833	384	53.85	1	384	3	389	0.0e+00	489	COG0153	Galactokinase	390
644855834	347	60.59	10	345	1	336	4.0e-120	424	COG1085	Galactose-1-phosphate uridylyltransferase	338
644855835	341	40.12	4	331	1	329	7.0e-86	310	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
644855836	330	33.73	1	330	4	317	8.0e-42	164	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
644855837	512	47.9	12	509	1	498	0.0e+00	654	COG1129	ABC-type sugar transport system, ATPase component	500
644855838	336	82.14	1	336	1	336	0.0e+00	492	COG4211	ABC-type glucose/galactose transport system, permease component	336
644855840	616	28.15	6	345	1	332	6.0e-40	159	COG0642	Signal transduction histidine kinase	336
644855841	406	48.54	1	404	2	411	2.0e-122	432	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
644855842	444	40.87	1	251	3	252	4.0e-78	285	COG4121	tRNA U34 5-methylaminomethyl-2-thiouridine-forming methyltransferase MnmC	252
644855846	191	45.21	4	191	9	191	3.0e-38	151	COG0576	Molecular chaperone GrpE (heat shock protein)	193
644855847	305	42.11	17	300	1	279	1.0e-75	276	COG0061	NAD kinase	281
644855848	558	46.96	1	558	1	556	0.0e+00	581	COG0497	DNA repair ATPase RecN	557
644855851	183	54.24	1	177	1	177	4.0e-51	194	COG2917	Intracellular septation protein A	180
644855852	153	50	8	149	4	142	5.0e-46	177	COG1607	Acyl-CoA hydrolase	157
644855853	98	58.16	1	98	1	92	5.0e-25	106	COG2350	Uncharacterized conserved protein YciI, contains a putative active-site phosphohistidine	92
644855854	745	30.91	525	736	77	295	1.0e-22	102	COG0741	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)	296
644855855	98	48.04	1	98	1	102	5.0e-28	115	COG2973	Trp operon repressor	103
644855857	386	60.78	1	385	5	387	0.0e+00	468	COG3004	Na+/H+ antiporter NhaA	390
644855860	237	45.1	25	228	31	226	2.0e-53	202	COG3910	Predicted ATPase	233
644855862	116	56.32	1	87	1	86	4.0e-17	79.9	COG1314	Preprotein translocase subunit SecG	86
644855864	634	32.01	1	625	1	570	0.0e+00	524	COG0550	DNA topoisomerase IA	570
644855865	200	56.28	1	199	1	198	4.0e-83	300	COG0353	Recombinational DNA repair protein RecR	198
644855866	109	62.62	1	106	1	105	5.0e-27	112	COG0718	Conserved DNA-binding protein YbaB (function unknown)	105
644855868	356	27.87	92	355	3	283	8.0e-26	111	COG1408	Predicted phosphohydrolase, MPP superfamily	284
644855869	297	50.18	20	296	31	307	8.0e-94	336	COG4594	ABC-type Fe3+-citrate transport system, periplasmic component	310
644855870	329	42.86	4	328	2	329	8.0e-49	187	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
644855871	327	42.07	9	327	3	330	5.0e-55	208	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
644855872	255	47.24	1	253	1	254	6.0e-86	310	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
644855873	323	65.63	1	323	1	322	0.0e+00	474	COG2269	Elongation factor P--beta-lysine ligase (EF-P beta-lysylation pathway)	322
644855874	602	51.56	1	571	2	562	0.0e+00	616	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	562
644855875	256	46.75	6	250	2	234	2.0e-82	299	COG0479	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit	234
644855876	130	49.22	6	130	2	129	2.0e-30	124	COG3029	Fumarate reductase subunit C	129
644855877	114	51.69	1	114	1	118	6.0e-34	136	COG3080	Fumarate reductase subunit D	118
644855878	363	58.01	1	359	1	348	0.0e+00	520	COG0809	S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)	348
644855879	378	33.62	37	376	25	355	2.0e-59	223	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
644855880	383	61.87	3	377	1	370	0.0e+00	560	COG0343	Queuine/archaeosine tRNA-ribosyltransferase	372
644855882	73	25.35	3	73	6	76	1.0e-07	48.3	COG0425	TusA-related sulfurtransferase	78
644855883	99	44.44	1	99	1	97	2.0e-24	104	COG1862	Preprotein translocase subunit YajC	97
644855884	616	48.81	75	616	1	506	0.0e+00	496	COG0342	Preprotein translocase subunit SecD	506
644855885	321	47.19	16	316	3	305	3.0e-83	302	COG0341	Preprotein translocase subunit SecF	305
644855887	873	44.88	462	865	1	377	7.0e-120	425	COG1454	Alcohol dehydrogenase, class IV	377
644855889	502	35.95	6	487	3	470	1.0e-112	400	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
644855890	447	32.87	21	436	21	435	4.0e-79	288	COG2271	Sugar phosphate permease	448
644855891	267	40.36	14	233	10	231	6.0e-58	217	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
644855892	276	58.46	1	271	1	269	2.0e-107	381	COG3718	5-deoxy-D-glucuronate isomerase	270
644855893	280	32.48	9	278	4	267	1.0e-47	183	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
644855894	636	50.67	340	636	6	303	6.0e-111	395	COG3892	Myo-inositol catabolism protein IolC	310
644855895	646	53.24	1	646	2	617	0.0e+00	902	COG3962	TPP-dependent trihydroxycyclohexane-1,2-dione (THcHDO) dehydratase, myo-inositol metabolism	617
644855896	298	27.09	8	294	1	270	5.0e-34	138	COG1082	Sugar phosphate isomerase/epimerase	274
644855897	336	34.3	1	334	3	342	6.0e-59	221	COG0673	Predicted dehydrogenase	342
644855899	441	27.23	233	436	58	281	3.0e-14	73.5	COG0790	TPR repeat	292
644855900	420	64.82	6	419	5	412	0.0e+00	664	COG0112	Glycine/serine hydroxymethyltransferase	413
644855903	429	63.17	1	427	1	427	0.0e+00	629	COG0151	Phosphoribosylamine-glycine ligase	428
644855904	533	65.6	6	533	1	515	0.0e+00	827	COG0138	AICAR transformylase/IMP cyclohydrolase PurH	515
644855905	473	36.05	98	468	4	375	2.0e-73	270	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
644855906	334	44.9	42	333	7	298	1.0e-85	310	COG2813	16S rRNA G1207 methylase RsmC	300
644855907	150	45.45	14	143	3	127	1.0e-25	109	COG3050	DNA polymerase III, psi subunit	133
644855908	147	30.72	1	147	11	176	6.0e-19	86.6	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
644855909	1125	41.93	1	1120	1	1074	0.0e+00	948	COG1330	Exonuclease V gamma subunit	1078
644855912	226	24.89	1	222	15	193	5.0e-27	114	COG4795	Type II secretory pathway, component PulJ	194
644855913	173	14.71	1	169	6	149	4.0e-10	57.8	COG2165	Type II secretory pathway, pseudopilin PulG	149
644855918	426	48.48	8	424	1	425	1.0e-107	383	COG0823	Periplasmic component of the Tol biopolymer transport system	425
644855919	140	35.71	1	140	3	135	7.0e-26	109	COG0848	Biopolymer transport protein ExbD	137
644855920	229	42.13	10	225	1	216	8.0e-54	203	COG0811	Biopolymer transport protein ExbB/TolQ	216
644855921	134	40.15	1	132	1	131	7.0e-32	129	COG0824	Acyl-CoA thioesterase FadM	137
644855922	378	45.36	1	373	1	346	1.0e-83	303	COG1294	Cytochrome bd-type quinol oxidase, subunit 2	346
644855925	334	70.12	4	331	1	328	0.0e+00	538	COG2255	Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit	332
644855926	204	51.46	1	204	1	201	7.0e-60	223	COG0632	Holliday junction resolvasome RuvABC DNA-binding subunit	201
644855927	190	60.62	5	163	1	160	7.0e-58	216	COG0817	Holliday junction resolvasome RuvABC endonuclease subunit	160
644855929	246	62.81	1	240	1	241	3.0e-100	358	COG0217	Transcriptional and/or translational regulatory protein YebC/TACO1	241
644855930	144	23.19	9	144	14	149	9.0e-09	53.1	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
644855933	592	60.68	2	586	1	584	0.0e+00	928	COG0173	Aspartyl-tRNA synthetase	585
644855935	848	28.72	1	661	1	636	5.0e-39	156	COG4984	Uncharacterized membrane protein	644
644855936	443	48.65	1	443	1	442	0.0e+00	483	COG2271	Sugar phosphate permease	448
644855938	650	18.71	64	650	103	768	5.0e-30	126	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
644855939	135	26.95	1	125	1	138	1.0e-14	72.2	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
644855940	217	27.92	11	204	1	182	3.0e-20	91.8	COG0847	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease	243
644855941	450	62.67	3	450	1	444	0.0e+00	539	COG2056	Predicted histidine transporter YuiF, NhaC family	444
644855942	188	26.63	5	186	6	175	9.0e-11	60	COG3923	Primosomal replication protein N''	175
644855943	474	54.18	1	440	1	436	0.0e+00	571	COG0621	tRNA A37 methylthiotransferase MiaB	437
644855946	242	61.95	38	241	1	204	2.0e-87	315	COG1636	Predicted ATPase, Adenine nucleotide alpha hydrolases (AANH) superfamily	204
644855948	323	40.67	4	323	1	322	2.0e-80	292	COG0142	Geranylgeranyl pyrophosphate synthase	322
644855949	103	63.11	1	103	1	103	2.0e-34	136	COG0261	Ribosomal protein L21	103
644855950	85	78.82	1	85	1	84	4.0e-30	122	COG0211	Ribosomal protein L27	87
644855951	305	22.92	1	299	1	290	1.0e-05	44.1	COG0697	Permease of the drug/metabolite transporter (DMT) superfamily	292
644855952	390	60.11	1	368	1	369	0.0e+00	532	COG0536	GTPase involved in cell partioning and DNA repair	369
644855954	160	59.48	7	159	2	153	5.0e-55	206	COG0691	tmRNA-binding protein	153
644855955	488	58.3	1	482	1	470	0.0e+00	676	COG0043	3-polyprenyl-4-hydroxybenzoate decarboxylase	477
644855956	541	39.18	1	540	5	562	1.0e-122	433	COG4166	ABC-type oligopeptide transport system, periplasmic component	562
644855957	306	47.47	1	306	1	315	3.0e-85	308	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
644855958	312	44.76	28	312	3	287	3.0e-73	269	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
644855959	327	57.05	7	322	1	316	1.0e-128	452	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
644855961	234	39.39	4	232	1	228	6.0e-53	200	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
644855963	88	38.37	1	86	1	74	3.0e-18	83.4	COG0254	Ribosomal protein L31	75
644855966	597	45.33	2	594	1	569	0.0e+00	583	COG4232	Thiol:disulfide interchange protein	569
644855969	959	54.16	1	491	1	487	0.0e+00	551	COG1530	Ribonuclease G or E	487
644855970	319	42	10	305	1	288	2.0e-75	276	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
644855972	331	47.32	1	331	1	324	1.0e-98	353	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
644855973	425	47.47	57	425	2	396	0.0e+00	477	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
644855977	450	37.47	4	450	3	446	6.0e-118	417	COG0527	Aspartokinase	447
644855978	420	58.81	1	420	1	417	0.0e+00	594	COG0014	Gamma-glutamyl phosphate reductase	417
644855981	335	62.76	1	333	1	326	0.0e+00	488	COG0158	Fructose-1,6-bisphosphatase	326
644855982	457	42.58	2	454	6	459	0.0e+00	518	COG0773	UDP-N-acetylmuramate-alanine ligase	459
644855984	372	45.92	12	371	10	363	2.0e-111	396	COG2821	Membrane-bound lytic murein transglycosylase	373
644855985	254	59.77	1	254	3	258	5.0e-99	354	COG1179	tRNA A37 threonylcarbamoyladenosine dehydratase	263
644855986	336	47.73	6	336	9	318	7.0e-109	387	COG4531	ABC-type Zn2+ transport system, periplasmic component/surface adhesin	318
644855987	625	40.77	9	393	8	391	1.0e-65	244	COG0475	Kef-type K+ transport system, membrane component KefB	397
644855988	270	52.73	1	270	1	274	2.0e-86	312	COG2503	Predicted secreted acid phosphatase	274
644855995	300	42.16	5	269	4	269	3.0e-79	288	COG0796	Glutamate racemase	269
644855996	97	57.89	3	97	2	96	3.0e-33	133	COG2914	Putative antitoxin component PasI (RatB) of the RatAB toxin-antitoxin module, ubiquitin-RnfH superfamily	99
644855997	143	45.83	1	143	1	144	4.0e-48	183	COG2867	Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module	146
644855998	138	44.53	1	137	2	138	1.0e-24	105	COG2510	Uncharacterized membrane protein	140
644855999	334	65.57	2	332	1	333	0.0e+00	471	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	335
644856000	208	58.03	1	193	1	189	3.0e-76	278	COG0194	Guanylate kinase	191
644856001	88	46.58	1	72	1	73	2.0e-12	64.6	COG1758	DNA-directed RNA polymerase, subunit K/omega	74
644856002	707	44.27	1	704	6	701	0.0e+00	885	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	701
644856003	693	54.56	1	686	1	677	0.0e+00	890	COG1200	RecG-like helicase	677
644856004	167	32.5	17	161	10	168	6.0e-21	93.9	COG3161	4-hydroxybenzoate synthetase (chorismate-pyruvate lyase)	174
644856005	404	38.34	1	386	6	375	2.0e-99	356	COG2850	Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain	383
644856006	446	51.71	6	444	4	437	0.0e+00	528	COG1570	Exonuclease VII, large subunit	440
644856007	284	51.74	1	282	1	286	2.0e-109	388	COG1660	RNase adaptor protein for sRNA GlmZ degradation, contains a P-loop ATPase domain	286
644856008	175	30.72	2	152	1	151	7.0e-26	110	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
644856009	241	73.55	1	241	2	243	4.0e-114	403	COG1137	ABC-type lipopolysaccharide export system, ATPase component	243
644856010	173	43.35	1	173	2	172	2.0e-41	161	COG1934	Lipopolysaccharide export system protein LptA	173
644856011	194	39.8	1	194	2	187	7.0e-43	167	COG3117	Lipopolysaccharide export system protein LptC	188
644856012	324	61.54	59	317	3	262	2.0e-110	392	COG1127	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, ATPase component MlaF	263
644856013	261	47.13	1	261	7	266	1.0e-69	256	COG0767	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, permease component MlaE	267
644856015	213	37.5	7	205	4	202	6.0e-49	187	COG2854	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, periplasmic MlaC component	202
644856016	119	39.62	7	112	1	99	1.0e-18	84.9	COG3113	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, MlaB component, contains STAS domain	99
644856017	85	55.7	1	79	1	79	7.0e-26	108	COG5007	Acid stress-induced BolA-like protein IbaG/YrbA, predicted regulator of iron metabolism	80
644856018	425	64.37	1	421	1	421	0.0e+00	645	COG0766	UDP-N-acetylglucosamine enolpyruvyl transferase	421
644856019	177	65.14	2	175	7	181	1.0e-49	189	COG3028	Ribosomal 50S subunit-associated protein YjgA (function unknown), DUF615 family	187
644856020	453	37.72	22	453	3	454	9.0e-93	334	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
644856021	166	56.97	2	166	18	178	2.0e-62	231	COG0634	Hypoxanthine-guanine phosphoribosyltransferase	178
644856022	379	65.07	1	375	1	375	0.0e+00	517	COG1929	Glycerate kinase	378
644856023	418	28.67	1	417	1	441	1.0e-49	190	COG2610	H+/gluconate symporter or related permease	442
644856024	367	43.97	1	366	1	372	4.0e-100	358	COG3835	Sugar diacid utilization regulator	376
644856025	369	37	1	367	20	389	2.0e-91	329	COG4671	Predicted glycosyl transferase	400
644856027	566	40.71	27	564	40	564	2.0e-121	429	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
644856030	600	37.21	2	518	25	513	2.0e-123	436	COG0513	Superfamily II DNA and RNA helicase	513
644856031	322	49.64	41	320	13	289	3.0e-104	371	COG4785	Lipoprotein NlpI, contains TPR repeats	297
644856032	709	63.78	1	693	2	692	0.0e+00	1007	COG1185	Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)	692
644856033	156	42.58	1	154	1	153	2.0e-40	158	COG2731	Beta-galactosidase, beta subunit	154
644856036	149	34.68	14	136	4	125	3.0e-19	87.7	COG4969	Tfp pilus assembly protein, major pilin PilA	125
644856037	469	41.52	19	466	1	500	2.0e-130	459	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
644856038	412	29.54	4	412	1	397	5.0e-79	288	COG1459	Type II secretory pathway, component PulF	397
644856040	206	42.44	1	205	1	201	2.0e-56	212	COG0237	Dephospho-CoA kinase	201
644856041	70	57.81	1	64	1	64	7.0e-18	82	COG3024	Endogenous inhibitor of DNA gyrase, YacG/DUF329 family	65
644856042	88	31.82	1	88	4	91	1.0e-18	85	COG2388	Predicted acetyltransferase, GNAT superfamily	99
644856043	457	54.24	1	446	2	447	0.0e+00	522	COG1115	Na+/alanine symporter	452
644856045	749	47.65	3	745	1	714	0.0e+00	688	COG3256	Nitric oxide reductase large subunit	717
644856050	1297	40.29	160	987	1	741	0.0e+00	807	COG0046	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain	743
644856051	98	77.55	1	98	1	98	1.0e-36	144	COG2901	DNA-binding protein Fis (factor for inversion stimulation)	98
644856052	320	43.03	1	320	2	321	4.0e-95	341	COG0042	tRNA-dihydrouridine synthase	323
644856053	294	54.52	1	293	2	300	7.0e-103	367	COG2264	Ribosomal protein L11 methylase PrmA	300
644856054	476	68.58	3	473	1	469	0.0e+00	589	COG4145	Na+/panthothenate symporter	473
644856055	91	57.69	3	80	1	78	9.0e-30	121	COG3924	Uncharacterized membrane protein YhdT	80
644856057	263	36.78	2	262	1	254	5.0e-68	251	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
644856058	170	51.16	1	170	1	158	2.0e-53	202	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
644856059	459	59.91	1	459	1	464	0.0e+00	706	COG0215	Cysteinyl-tRNA synthetase	464
644856060	320	64.29	13	320	1	306	0.0e+00	509	COG0320	Lipoate synthase	306
644856061	212	52.38	1	208	7	213	2.0e-76	278	COG0321	Lipoate-protein ligase B	221
644856062	100	57.95	15	100	3	90	3.0e-27	113	COG2921	Putative lipoic acid-binding regulatory protein	90
644856063	294	34.11	19	228	31	233	3.0e-37	149	COG0797	Rare lipoprotein A, peptidoglycan hydrolase digesting "naked" glycans, contains C-terminal SPOR domain	233
644856064	371	42.33	3	368	2	377	5.0e-77	281	COG0772	Bacterial cell division protein FtsW, lipid II flippase	381
644856065	649	37.6	16	631	4	599	0.0e+00	513	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
644856066	155	54.19	1	154	1	155	1.0e-62	232	COG1576	23S rRNA pseudoU1915 N3-methylase RlmH	155
644856067	102	45.1	1	102	4	105	6.0e-30	122	COG0799	Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits	115
644856068	433	41.65	14	433	20	439	9.0e-111	394	COG0513	Superfamily II DNA and RNA helicase	513
644856069	420	78.57	1	420	4	421	0.0e+00	724	COG1158	Transcription termination factor Rho	422
644856070	408	24.1	10	396	12	383	4.0e-21	96	COG2814	Predicted arabinose efflux permease, MFS family	394
644856071	76	68.42	1	76	4	79	5.0e-12	62.6	COG0236	Acyl carrier protein	80
644856072	242	47.81	1	239	3	250	8.0e-53	200	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
644856073	312	56.63	1	309	1	309	2.0e-106	379	COG0331	Malonyl CoA-acyl carrier protein transacylase	310
644856074	316	57.01	1	316	2	322	6.0e-117	413	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
644856075	344	46.47	3	342	1	337	1.0e-108	386	COG0416	Fatty acid/phospholipid biosynthesis enzyme	338
644856076	56	54.39	1	56	1	57	1.0e-11	61.4	COG0333	Ribosomal protein L32	57
644856077	174	37.85	1	174	1	176	8.0e-36	143	COG1399	Uncharacterized metal-binding protein YceD, DUF177 family	176
644856078	213	39.13	1	182	1	180	6.0e-51	193	COG0132	Dethiobiotin synthetase	223
644856080	217	55.09	1	216	1	213	1.0e-74	273	COG2830	Uncharacterized protein	214
644856081	390	40.05	1	384	1	384	2.0e-113	402	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
644856082	429	44.04	2	427	1	445	0.0e+00	516	COG0161	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	449
644856085	431	23.53	293	425	30	165	4.0e-08	53.2	COG2453	Protein-tyrosine phosphatase	180
644856086	594	33.33	18	292	10	294	7.0e-45	175	COG2267	Lysophospholipase, alpha-beta hydrolase superfamily	298
644856087	289	31.87	14	285	2	239	3.0e-56	212	COG0688	Phosphatidylserine decarboxylase	239
644856088	210	49.27	6	210	1	205	3.0e-59	221	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	205
644856089	368	56.44	6	368	7	369	0.0e+00	475	COG0263	Glutamate 5-kinase	369
644856090	261	39.18	6	246	7	250	3.0e-54	205	COG2966	Uncharacterized membrane protein YjjP, DUF1212 family	250
644856091	154	50.98	4	154	3	155	1.0e-29	122	COG3610	Uncharacterized membrane protein YjjB, DUF3815 family	156
644856092	161	44.64	3	160	2	167	8.0e-41	159	COG0262	Dihydrofolate reductase	167
644856093	458	36.47	24	454	1	427	3.0e-96	346	COG1253	Hemolysin or related protein, contains CBS domains	429
644856095	260	54.62	1	257	1	256	6.0e-84	304	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
644856097	210	48.31	1	205	1	205	5.0e-59	220	COG0125	Thymidylate kinase	208
644856100	351	28.49	7	345	13	354	9.0e-32	131	COG0628	Predicted PurR-regulated permease PerM	355
644856101	127	75	16	127	1	112	1.0e-42	165	COG0347	Nitrogen regulatory protein PII	112
644856103	272	32.6	1	272	1	262	4.0e-57	214	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
644856108	193	43.18	5	179	8	169	2.0e-48	185	COG0521	Molybdopterin biosynthesis enzyme MoaB	169
644856109	309	52.75	1	309	1	303	1.0e-103	369	COG4589	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase	303
644856110	210	25	8	206	38	229	2.0e-13	69.2	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
644856111	202	28.87	14	202	1	191	1.0e-18	86.6	COG0558	Phosphatidylglycerophosphate synthase	192
644856112	620	20.34	36	620	5	458	1.0e-44	175	COG0471	Di- and tricarboxylate transporter	461
644856113	195	58.06	12	194	1	186	9.0e-65	239	COG0164	Ribonuclease HII	199
644856114	394	57.66	11	391	2	381	0.0e+00	476	COG0763	Lipid A disaccharide synthetase	381
644856115	262	63.08	3	262	1	260	2.0e-111	394	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	260
644856116	150	55.24	8	148	3	144	7.0e-47	179	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
644856117	340	52.51	1	339	1	338	8.0e-110	390	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	338
644856118	192	36.51	1	189	1	169	1.0e-16	79.6	COG2825	Periplasmic chaperone for outer membrane proteins, Skp family	170
644856119	799	41.34	1	799	3	766	0.0e+00	702	COG4775	Outer membrane protein assembly factor BamA	766
644856120	443	37.67	3	443	1	373	1.0e-57	217	COG0750	Membrane-associated protease RseP, regulator of RpoE activity	375
644856121	289	36.68	1	288	1	265	7.0e-35	141	COG0575	CDP-diglyceride synthetase	265
644856122	239	57.51	6	238	13	245	4.0e-96	344	COG0020	Undecaprenyl pyrophosphate synthase	245
644856123	401	54.04	4	398	1	382	0.0e+00	544	COG0743	1-deoxy-D-xylulose 5-phosphate reductoisomerase	385
644856125	185	63.78	1	185	3	187	2.0e-65	241	COG0233	Ribosome recycling factor	187
644856126	237	59.49	2	237	1	237	9.0e-91	326	COG0528	Uridylate kinase	238
644856127	552	51.91	1	550	1	544	0.0e+00	587	COG2985	Uncharacterized membrane protein YbjL, putative transporter	544
644856128	594	42.02	13	591	1	594	0.0e+00	622	COG4178	ABC-type uncharacterized transport system, permease and ATPase components	604
644856130	515	48.92	3	414	1	409	7.0e-123	434	COG0119	Isopropylmalate/homocitrate/citramalate synthases	409
644856131	358	57.66	1	355	1	342	0.0e+00	465	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
644856132	485	59.36	17	482	1	422	0.0e+00	638	COG0065	Homoaconitase/3-isopropylmalate dehydratase large subunit	423
644856133	200	57.71	1	200	1	191	2.0e-79	288	COG0066	3-isopropylmalate dehydratase small subunit	191
644856136	414	42.03	1	409	3	415	3.0e-73	269	COG0814	Amino acid permease	415
644856137	175	61.14	1	175	1	171	6.0e-58	217	COG0221	Inorganic pyrophosphatase	171
644856138	257	22.87	41	246	79	299	2.0e-24	106	COG0501	Zn-dependent protease with chaperone function	302
644856139	252	31.05	5	252	1	242	8.0e-25	107	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
644856140	158	38.76	2	127	11	137	2.0e-22	98.4	COG0848	Biopolymer transport protein ExbD	137
644856142	420	58.85	5	420	1	416	0.0e+00	565	COG4536	Mg2+ and Co2+ transporter CorB, contains DUF21, CBS pair, and CorC-HlyC domains	423
644856143	264	39.77	1	263	3	258	1.0e-50	193	COG4137	ABC-type uncharacterized transport system, permease component	265
644856144	459	63.58	1	452	1	451	0.0e+00	635	COG0541	Signal recognition particle GTPase	451
644856146	813	59.85	1	807	1	809	0.0e+00	1093	COG2937	Glycerol-3-phosphate O-acyltransferase	810
644856147	208	45.67	1	206	1	201	4.0e-56	211	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	201
644856148	125	54.95	2	111	1	111	7.0e-36	142	COG0360	Ribosomal protein S6	112
644856149	103	62.14	1	103	1	103	1.0e-35	140	COG2965	Primosomal replication protein N	103
644856150	76	73.53	1	68	8	75	2.0e-21	93.8	COG0238	Ribosomal protein S18	75
644856151	149	54.36	1	149	1	147	2.0e-42	164	COG0359	Ribosomal protein L9	148
644856152	371	39.34	6	370	7	348	8.0e-96	343	COG0758	Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake	350
644856153	124	77.24	1	123	7	129	3.0e-49	187	COG0048	Ribosomal protein S12	129
644856154	156	62.84	2	149	1	148	5.0e-55	206	COG0049	Ribosomal protein S7	148
644856155	700	67.47	1	700	1	693	0.0e+00	1014	COG0480	Translation elongation factor EF-G, a GTPase	697
644856156	394	84.77	1	394	1	394	0.0e+00	725	COG0050	Translation elongation factor EF-Tu, a GTPase	394
644856157	771	61.49	1	769	5	780	0.0e+00	1038	COG2183	Transcriptional accessory protein Tex/SPT6	780
644856158	159	42.11	7	157	1	151	2.0e-38	151	COG0782	Transcription elongation factor, GreA/GreB family	151
644856160	193	25.27	10	191	18	182	2.0e-26	112	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
644856162	242	40.08	1	231	10	233	2.0e-39	155	COG1738	Uncharacterized PurR-regulated membrane protein YhhQ, DUF165 family	233
644856163	423	42.18	1	403	1	393	4.0e-108	385	COG3071	Uncharacterized conserved protein HemY, contains two TPR repeats	400
644856164	461	42.74	65	440	21	387	4.0e-81	295	COG2959	Uncharacterized conserved protein HemX (no evidence of involvement in heme biosynthesis)	391
644856165	248	30.08	1	246	2	243	3.0e-40	158	COG1587	Uroporphyrinogen-III synthase	248
644856166	308	61.76	4	308	2	307	2.0e-120	425	COG0181	Porphobilinogen deaminase	307
644856167	833	49.58	1	833	1	835	0.0e+00	1085	COG3072	Adenylate cyclase	853
644856168	209	45.89	5	207	1	207	2.0e-53	202	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
644856169	619	43.52	66	619	33	594	0.0e+00	518	COG0729	Outer membrane translocation and assembly module TamA	594
644856170	1300	37.37	14	1300	3	1278	0.0e+00	946	COG2911	Autotransporter translocation and assembly factor TamB	1278
644856171	515	42.48	19	504	1	488	0.0e+00	462	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	492
644856172	538	64.5	5	538	4	529	0.0e+00	833	COG1866	Phosphoenolpyruvate carboxykinase, ATP-dependent	529
644856174	384	61.43	22	382	1	355	0.0e+00	501	COG0482	tRNA U34 2-thiouridine synthase MnmA/TrmU, contains the PP-loop ATPase domain	356
644856175	85	63.51	1	74	1	74	6.0e-25	105	COG2991	Uncharacterized protein	77
644856176	362	43.59	13	361	9	337	2.0e-99	356	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
644856178	411	86.34	2	411	1	410	0.0e+00	779	COG2871	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF	410
644856179	198	83.84	1	198	1	198	2.0e-79	288	COG2209	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE	198
644856180	209	79.43	1	209	1	208	7.0e-90	323	COG1347	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD	208
644856181	261	56.87	1	260	2	260	4.0e-89	321	COG2869	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC	264
644856182	411	68.64	2	406	1	400	0.0e+00	524	COG1805	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB	400
644856183	446	76.29	1	446	1	447	0.0e+00	732	COG1726	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA	447
644856184	103	51.16	1	85	2	87	2.0e-22	97	COG0271	Stress-induced morphogen (activity unknown)	90
644856185	197	37.82	6	197	14	204	3.0e-49	187	COG3056	Uncharacterized lipoprotein YajG	204
644856189	359	22.01	49	353	1	296	9.0e-32	131	COG0741	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)	296
644856190	91	76.67	1	90	1	90	3.0e-38	149	COG2924	Fe-S cluster biosynthesis and repair protein YggX	90
644856191	379	50.4	1	370	1	342	2.0e-118	418	COG1194	Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs	342
644856193	113	63.96	1	111	9	119	3.0e-43	166	COG3171	Uncharacterized conserved protein YggL, DUF469 family	119
644856197	112	36.46	11	106	19	114	2.0e-14	71.2	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	124
644856198	348	27.46	8	344	1	329	1.0e-60	227	COG0859	ADP-heptose:LPS heptosyltransferase	334
644856200	165	35.83	50	165	24	143	1.0e-20	92.7	COG2847	Copper(I)-binding protein	151
644856201	203	58.45	1	203	1	207	2.0e-66	245	COG2915	Regulator of phage lambda lysogenization HflD, binds to CII and stimulates its degradation	207
644856202	455	33.99	12	455	1	435	3.0e-116	412	COG0015	Adenylosuccinate lyase	438
644856204	332	28.76	39	332	1	299	6.0e-38	151	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
644856207	409	18.47	1	398	1	371	5.0e-29	122	COG4637	Predicted ATPase	373
644856208	506	32.2	5	503	8	531	9.0e-87	314	COG1178	ABC-type Fe3+ transport system, permease component	540
644856209	353	39.83	3	344	1	342	9.0e-93	333	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
644856210	312	38.61	1	310	11	317	8.0e-76	277	COG0042	tRNA-dihydrouridine synthase	323
644856211	288	26.42	71	282	1	174	2.0e-30	126	COG1076	DnaJ-domain-containing proteins 1	174
644856212	213	36.32	3	211	1	201	1.0e-50	193	COG0461	Orotate phosphoribosyltransferase	201
644856213	238	60.5	1	237	8	230	1.0e-80	292	COG0689	Ribonuclease PH	230
644856214	287	53.1	1	287	1	290	3.0e-87	315	COG1561	Uncharacterized conserved protein YicC, UPF0701 family	290
644856215	295	36.07	3	295	5	304	2.0e-62	232	COG0354	Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification	305
644856216	280	45.36	1	279	10	289	7.0e-93	333	COG4667	Predicted phospholipase, patatin/cPLA2 family	292
644856217	161	45.81	5	157	9	156	3.0e-43	167	COG4875	Uncharacterized protein	156
644856218	240	63.33	1	240	1	239	7.0e-100	356	COG0052	Ribosomal protein S2	252
644856219	282	60.47	1	282	1	296	5.0e-95	341	COG0264	Translation elongation factor EF-Ts	296
644856220	214	40.45	2	211	26	245	2.0e-43	168	COG1381	Recombinational DNA repair protein (RecF pathway)	251
644856221	438	35.19	15	431	3	432	5.0e-114	405	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
644856222	742	54.01	9	742	1	701	0.0e+00	893	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	701
644856223	118	55.65	3	117	4	118	5.0e-33	132	COG0818	Diacylglycerol kinase	123
644856224	207	23.79	5	198	2	207	4.0e-19	88	COG1011	FMN phosphatase YigB, HAD superfamily	229
644856225	219	33	23	219	21	212	5.0e-28	117	COG4912	3-methyladenine DNA glycosylase AlkD	222
644856227	311	39.32	16	310	8	297	5.0e-75	274	COG2177	Cell division protein FtsX	297
644856228	216	59.26	1	216	1	216	5.0e-92	330	COG2884	ABC-type ATPase involved in cell division	223
644856229	495	55	159	491	1	340	3.0e-117	415	COG0552	Signal recognition particle GTPase	340
644856230	195	43.85	13	195	1	187	7.0e-61	226	COG0742	16S rRNA G966 N2-methylase RsmD	187
644856231	326	49.02	164	316	1	153	4.0e-46	178	COG3444	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB	159
644856232	265	53.44	1	246	2	247	1.0e-67	249	COG3715	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC	265
644856233	278	54.32	1	277	1	269	1.0e-98	353	COG3716	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID	269
644856234	390	30.8	132	389	3	262	1.0e-49	190	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
644856235	210	55.45	2	210	4	214	5.0e-79	287	COG0259	Pyridoxine/pyridoxamine 5'-phosphate oxidase	214
644856236	441	50.45	1	438	1	442	0.0e+00	490	COG2271	Sugar phosphate permease	448
644856237	246	38.06	1	246	3	249	2.0e-67	248	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
644856238	337	45.27	6	337	1	331	7.0e-58	217	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
644856239	334	26.74	28	304	42	319	3.0e-25	109	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
644856241	665	21.7	5	665	20	699	4.0e-38	153	COG4771	Outer membrane receptor for ferrienterochelin and colicins	699
644856243	411	27.34	10	404	14	428	2.0e-52	200	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
644856246	239	69.66	1	234	2	235	3.0e-107	381	COG0813	Purine-nucleoside phosphorylase	236
644856247	416	61.31	1	410	1	404	0.0e+00	461	COG1972	Nucleoside permease NupC	404
644856248	345	26.9	1	332	2	330	6.0e-55	207	COG0859	ADP-heptose:LPS heptosyltransferase	334
644856249	472	70.76	1	472	1	471	0.0e+00	795	COG1027	Aspartate ammonia-lyase	471
644856250	160	30.52	2	155	1	146	3.0e-21	94.5	COG3030	Protein affecting phage T7 exclusion by the F plasmid, UPF0716 family	158
644856251	97	55.67	1	97	1	96	3.0e-26	109	COG0234	Co-chaperonin GroES (HSP10)	96
644856252	547	48.99	1	529	1	519	0.0e+00	488	COG0459	Chaperonin GroEL (HSP60 family)	524
644856253	285	59.93	4	284	1	282	4.0e-115	407	COG0190	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	283
644856256	369	33.6	1	369	1	334	5.0e-103	368	COG0136	Aspartate-semialdehyde dehydrogenase	334
644856258	274	56.2	1	274	1	272	1.0e-107	383	COG0253	Diaminopimelate epimerase	272
644856259	295	61.9	1	294	6	299	1.0e-122	432	COG4973	Site-specific recombinase XerC	299
644856260	237	23.63	7	235	1	225	2.0e-24	106	COG1011	FMN phosphatase YigB, HAD superfamily	229
644856264	254	24.47	27	204	6	193	2.0e-11	63.4	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
644856266	83	23.38	1	77	1	77	3.0e-06	43.4	COG0236	Acyl carrier protein	80
644856267	558	20.88	5	430	28	518	3.0e-33	137	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
644856269	445	21.87	13	430	27	519	9.0e-29	121	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
644856271	308	33.66	3	304	1	300	4.0e-57	215	COG4261	Predicted acyltransferase, LPLAT superfamily	309
644856272	149	26.19	14	138	11	133	5.0e-15	73.8	COG0824	Acyl-CoA thioesterase FadM	137
644856275	761	22.89	9	750	14	775	1.0e-61	231	COG4258	Predicted exporter	788
644856277	305	19.02	3	303	99	394	9.0e-16	77.9	COG0644	Dehydrogenase (flavoprotein)	396
644856279	407	31.28	1	403	2	409	7.0e-66	244	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
644856280	147	34.25	6	145	7	152	3.0e-26	111	COG4706	Predicted 3-hydroxylacyl-ACP dehydratase, HotDog domain	161
644856281	242	44.22	1	241	4	250	4.0e-44	171	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
644856282	414	41.33	1	413	2	412	8.0e-111	393	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
644856283	455	23.08	4	442	40	437	2.0e-53	203	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
644856284	355	31.3	115	355	15	256	5.0e-43	168	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
644856287	231	34.8	2	231	1	237	2.0e-60	225	COG3719	Ribonuclease I	249
644856288	387	57.39	1	386	2	395	0.0e+00	500	COG0126	3-phosphoglycerate kinase	395
644856289	359	35.28	17	357	5	284	1.0e-90	326	COG0191	Fructose/tagatose bisphosphate aldolase	286
644856290	419	19.95	3	405	20	414	2.0e-18	87.5	COG3307	O-antigen ligase	424
644856291	317	27.91	9	304	2	291	5.0e-51	194	COG2267	Lysophospholipase, alpha-beta hydrolase superfamily	298
644856292	128	44	4	127	2	126	1.0e-16	78.7	COG0239	Fluoride ion exporter CrcB/FEX, affects chromosome condensation	126
644856293	272	30	5	271	2	263	1.0e-46	180	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
644856294	550	50	1	545	2	549	0.0e+00	607	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
644856295	71	51.39	1	70	2	73	6.0e-13	65.8	COG3978	Acetolactate synthase small subunit, contains ACT domain	86
644856298	612	53.58	1	611	8	575	0.0e+00	797	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
644856299	522	53.47	19	361	3	347	2.0e-126	446	COG1171	Threonine dehydratase	347
644856301	386	21.75	7	380	4	319	2.0e-37	150	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
644856304	240	41.03	1	230	4	236	5.0e-60	224	COG1131	ABC-type multidrug transport system, ATPase component	293
644856305	413	22.38	201	408	81	284	4.0e-12	66.5	COG0842	ABC-type multidrug transport system, permease component	286
644856317	174	57.14	5	174	1	174	1.0e-53	202	COG4635	Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain)	175
644856318	487	44.29	1	487	1	488	6.0e-105	375	COG0168	Trk-type K+ transport system, membrane component	499
644856320	79	39.74	3	79	1	78	2.0e-19	87.6	COG0425	TusA-related sulfurtransferase	78
644856321	82	48.68	1	76	10	85	9.0e-16	75.1	COG2960	Uncharacterized conserved protein YqiC, BMFP domain	103
644856322	423	65.24	224	410	1	186	4.0e-83	301	COG3172	Nicotinamide riboside kinase	187
644856324	409	40.05	1	404	5	415	6.0e-59	221	COG0814	Amino acid permease	415
644856327	856	57.58	5	856	1	783	0.0e+00	994	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
644856329	364	65.47	22	352	2	334	0.0e+00	519	COG0150	Phosphoribosylaminoimidazole (AIR) synthetase	345
644856330	212	50.5	2	201	1	200	4.0e-74	270	COG0299	Folate-dependent phosphoribosylglycinamide formyltransferase PurN	200
644856331	271	26.32	10	269	3	263	2.0e-37	149	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
644856332	228	41.05	1	228	7	223	5.0e-52	197	COG1040	Predicted amidophosphoribosyltransferases	225
644856333	194	48.94	100	192	1	93	1.0e-26	113	COG0694	Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain	93
644856334	200	53.92	1	101	8	108	9.0e-40	156	COG0139	Phosphoribosyl-AMP cyclohydrolase	111
644856336	257	53.49	1	256	1	254	2.0e-108	385	COG0107	Imidazole glycerol phosphate synthase subunit HisF	256
644856337	247	50.2	4	247	3	241	2.0e-78	285	COG0106	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase	241
644856338	151	24.39	2	119	8	130	3.0e-08	51	COG1943	REP element-mobilizing transposase RayT	136
644856339	199	50.74	3	199	1	203	2.0e-75	275	COG0118	Imidazoleglycerol phosphate synthase glutamine amidotransferase subunit HisH	204
644856341	362	64.62	171	362	1	195	1.0e-85	310	COG0131	Imidazoleglycerol phosphate dehydratase HisB	195
644856342	351	39.5	6	351	1	351	3.0e-90	325	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
644856343	428	53.74	6	428	1	425	0.0e+00	552	COG0141	Histidinol dehydrogenase	425
644856344	299	53.87	5	299	1	290	1.0e-98	353	COG0040	ATP phosphoribosyltransferase	290
644856345	433	43.32	1	433	1	431	2.0e-103	369	COG1114	Branched-chain amino acid permeases	431
644856346	544	66.61	3	542	1	532	0.0e+00	919	COG0504	CTP synthase (UTP-ammonia lyase)	533
644856347	220	35.9	26	220	16	208	7.0e-48	183	COG0352	Thiamine monophosphate synthase	211
644856348	436	67.59	1	435	1	423	0.0e+00	627	COG0148	Enolase	423
644856349	139	45.65	2	138	1	138	8.0e-45	172	COG0816	RNase H-fold protein, predicted Holliday junction resolvase in Firmicutes and mycoplasms, involved in anti-termination at Rho-dependent terminators	141
644856350	186	47.06	1	186	10	194	1.0e-60	225	COG1678	Putative transcriptional regulator, AlgH/UPF0301 family	194
644856351	244	44.94	1	242	1	246	1.0e-73	269	COG1385	16S rRNA U1498 N3-methylase RsmE	246
644856352	105	86.67	1	105	1	105	5.0e-51	192	COG3060	Transcriptional regulator of met regulon	105
644856353	295	57.63	1	295	5	291	5.0e-118	417	COG1210	UTP-glucose-1-phosphate uridylyltransferase	291
644856355	60	67.24	1	58	1	58	2.0e-16	77.6	COG1551	sRNA-binding carbon storage regulator CsrA	73
644856356	874	56.74	1	874	5	879	0.0e+00	1198	COG0013	Alanyl-tRNA synthetase	879
644856357	141	27.15	1	140	4	154	5.0e-11	60.4	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
644856359	329	19.44	22	329	58	356	6.0e-38	151	COG0402	Cytosine/adenosine deaminase or related metal-dependent hydrolase	421
644856360	579	50.5	5	579	4	600	0.0e+00	719	COG3083	Membrane-anchored periplasmic protein YejM, alkaline phosphatase superfamily	600
644856361	73	50.68	1	73	1	73	2.0e-18	83.9	COG3082	Uncharacterized conserved protein YejL, UPF0352 family	74
644856362	340	60.29	1	340	1	335	0.0e+00	491	COG3081	Nucleoid-associated protein YejK (function unknown)	335
644856363	137	37.14	3	137	7	146	6.0e-28	116	COG2913	Outer membrane protein assembly factor BamE, lipoprotein component of the BamABCDE complex	147
644856364	231	43.29	3	231	2	229	2.0e-56	212	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
644856365	462	32.15	158	462	34	333	5.0e-37	149	COG0642	Signal transduction histidine kinase	336
644856366	402	56.85	2	394	4	396	2.0e-120	426	COG0786	Na+/glutamate symporter	404
644856367	144	67.36	1	143	1	144	3.0e-62	230	COG1490	D-Tyr-tRNAtyr deacylase	145
644856368	278	25.44	4	278	16	302	2.0e-35	143	COG1295	Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase)	303
644856369	157	49.34	5	155	1	151	2.0e-56	211	COG3012	Uncharacterized conserved protein YchJ, contains N- and C-terminal SEC-C domains	151
644856370	222	37.5	4	217	1	210	6.0e-48	184	COG2258	Uncharacterized conserved protein YiiM, contains MOSC domain	210
644856371	499	26.45	19	496	6	520	5.0e-37	149	COG0433	Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase domains	520
644856372	271	27.34	4	269	10	296	1.0e-40	160	COG3315	O-Methyltransferase involved in polyketide biosynthesis	297
644856373	610	57.12	1	610	1	597	0.0e+00	825	COG0449	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains	597
644856374	258	44.84	10	258	2	252	8.0e-58	217	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
644856375	90	64.44	1	90	2	91	3.0e-25	106	COG0776	Bacterial nucleoid DNA-binding protein	94
644856376	196	55.15	1	194	2	194	2.0e-74	271	COG3068	Uncharacterized protein YjaG, DUF416 family	194
644856377	354	56.09	1	352	2	352	0.0e+00	463	COG0407	Uroporphyrinogen-III decarboxylase	352
644856378	260	44.53	1	260	11	275	1.0e-81	296	COG2816	NADH pyrophosphatase NudC, Nudix superfamily	279
644856379	1422	51.34	21	854	7	808	0.0e+00	912	COG0086	DNA-directed RNA polymerase, beta' subunit/160 kD subunit	808
644856381	123	71.77	1	123	1	124	2.0e-21	94.5	COG0222	Ribosomal protein L7/L12	124
644856382	163	49.39	1	160	1	163	2.0e-38	151	COG0244	Ribosomal protein L10	175
644856383	229	57.89	1	227	1	228	4.0e-81	294	COG0081	Ribosomal protein L1	228
644856384	142	71.43	2	141	1	139	2.0e-50	191	COG0080	Ribosomal protein L11	141
644856385	183	53.98	6	181	1	176	9.0e-56	209	COG0250	Transcription antitermination factor NusG	178
644856386	136	46.58	58	130	1	73	3.0e-12	64.3	COG0690	Preprotein translocase subunit SecE	73
644856387	171	37.65	1	170	1	158	4.0e-41	160	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
644856388	102	46.34	13	93	18	99	8.0e-13	65.4	COG2944	DNA-binding transcriptional regulator YiaG, XRE-type HTH domain	104
644856403	69	33.33	1	69	7	69	2.0e-08	50.7	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
644856405	414	22.62	96	393	3	303	2.0e-10	60.4	COG0582	Integrase	309
644856406	363	25	169	357	40	219	9.0e-16	77.9	COG1434	Uncharacterized SAM-binding protein YcdF, DUF218 family	223
644856408	374	24.23	12	365	4	348	4.0e-28	119	COG3177	Fic family protein	348
644856409	637	19.47	268	614	110	463	1.0e-24	108	COG0286	Type I restriction-modification system, DNA methylase subunit	489
644856412	866	49.83	5	862	1	843	0.0e+00	982	COG0249	DNA mismatch repair ATPase MutS	843
644856413	441	42.63	5	441	29	458	2.0e-103	369	COG0513	Superfamily II DNA and RNA helicase	513
644856414	234	37.19	1	234	8	248	1.0e-57	216	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	248
644856415	241	35.02	30	241	2	217	4.0e-42	164	COG3201	Nicotinamide riboside transporter PnuC	222
644856416	952	24.65	63	952	12	861	6.0e-48	186	COG0553	Superfamily II DNA or RNA helicase, SNF2 family	866
644856417	219	39.01	1	216	69	286	2.0e-59	222	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
644856418	165	46.39	2	165	5	168	1.0e-41	162	COG3516	Predicted component of the type VI protein secretion system	169
644856419	494	53.33	1	490	1	491	0.0e+00	692	COG3517	Predicted component of the type VI protein secretion system	495
644856420	138	27.87	26	137	32	153	5.0e-12	63.8	COG3518	Predicted component of the type VI protein secretion system	157
644856421	583	33.01	1	583	3	621	3.0e-127	448	COG3519	Type VI protein secretion system component VasA	621
644856422	332	27.63	11	313	18	317	2.0e-53	203	COG3520	Predicted component of the type VI protein secretion system	335
644856424	228	31.5	96	215	21	145	1.0e-15	76.9	COG3521	Predicted component of the type VI protein secretion system	159
644856425	447	40.13	1	444	1	446	2.0e-111	396	COG3522	Predicted component of the type VI protein secretion system	446
644856426	285	33.75	46	281	19	258	8.0e-45	174	COG3455	Type VI protein secretion system component VasF	262
644856429	1165	28.42	9	1138	47	1187	0.0e+00	651	COG3523	Type VI protein secretion system component VasK	1188
644856431	1076	20.9	574	1076	83	577	2.0e-19	92.4	COG4625	Uncharacterized conserved protein, contains a C-terminal beta-barrel porin domain	577
644856432	214	63.5	14	213	4	202	1.0e-81	295	COG0108	3,4-dihydroxy-2-butanone 4-phosphate synthase	203
644856433	309	24.92	11	309	9	310	2.0e-14	73.8	COG0679	Predicted permease	311
644856437	554	58.58	222	554	1	337	2.0e-97	349	COG1299	Phosphotransferase system, fructose-specific IIC component	343
644856438	313	49.52	3	312	1	310	4.0e-99	354	COG1105	Fructose-1-phosphate kinase or kinase (PfkB)	310
644856439	512	58.45	2	143	1	142	7.0e-49	188	COG4668	Mannitol/fructose-specific phosphotransferase system, IIA domain	142
644856441	193	44.33	1	193	1	191	4.0e-51	194	COG0746	Molybdopterin-guanine dinucleotide biosynthesis protein A	192
644856442	88	70.45	1	88	1	88	2.0e-36	143	COG3084	Uncharacterized protein YihD, DUF1040 family	88
644856444	109	61.82	1	109	1	110	1.0e-39	154	COG3085	Uncharacterized conserved protein YifE, UPF0438 family	112
644856445	365	30.25	4	357	80	432	2.0e-80	292	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
644856459	304	60.68	10	304	1	295	4.0e-112	397	COG2103	N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase	298
644856460	376	53.87	1	373	2	371	9.0e-125	440	COG2377	1,6-Anhydro-N-acetylmuramate kinase	371
644856461	455	57.64	4	455	1	458	0.0e+00	659	COG1207	Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	460
644856462	442	41.28	1	436	3	431	6.0e-98	351	COG1114	Branched-chain amino acid permeases	431
644856463	426	61.7	1	423	6	426	0.0e+00	617	COG2873	O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent	426
644856465	388	46.5	1	388	1	387	1.0e-125	443	COG0754	Glutathionylspermidine synthase	387
644856466	105	21.65	5	100	15	107	7.0e-07	45.8	COG0662	Mannose-6-phosphate isomerase, cupin superfamily	127
644856467	985	59.5	389	985	3	593	0.0e+00	807	COG0749	DNA polymerase I - 3'-5' exonuclease and polymerase domains	593
644856468	185	24.62	1	185	1	199	6.0e-12	64.3	COG3637	Opacity protein and related surface antigens	199
644856469	76	46.58	7	75	3	75	1.0e-14	71.1	COG5645	Uncharacterized conserved protein YceK	80
644856470	671	47.05	1	651	1	655	0.0e+00	616	COG0210	Superfamily I DNA or RNA helicase	655
644856475	202	31.55	9	193	1	187	7.0e-37	147	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
644856476	204	36.22	16	197	6	190	4.0e-35	141	COG0110	Acetyltransferase (isoleucine patch superfamily)	190
644856477	155	30.57	1	152	1	148	5.0e-15	73.8	COG1238	Uncharacterized membrane protein YqaA, SNARE-associated domain	161
644856478	168	62.35	1	162	1	161	1.0e-70	258	COG1854	S-ribosylhomocysteine lyase LuxS, autoinducer biosynthesis	161
644856479	393	68.62	1	391	1	392	0.0e+00	614	COG0027	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	394
644856483	223	56.82	1	217	3	222	5.0e-75	274	COG0274	Deoxyribose-phosphate aldolase	228
644856484	249	30.96	4	240	2	238	7.0e-49	187	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
644856485	511	58.42	15	501	1	489	0.0e+00	649	COG0606	Predicted ATPase with chaperone activity	490
644856491	361	23.22	86	292	24	232	2.0e-15	77	COG0790	TPR repeat	292
644856493	301	49.12	50	274	29	250	4.0e-73	268	COG2861	Uncharacterized conserved protein YibQ, putative polysaccharide deacetylase 2 family	250
644856494	432	45.25	36	432	20	419	2.0e-90	326	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	420
644856496	287	52.16	1	281	1	301	9.0e-80	290	COG2354	Uncharacterized membrane protein MutK, may be involved in DNA repair	303
644856502	317	39.17	5	314	1	238	7.0e-64	237	COG0176	Transaldolase	239
644856503	665	66.72	1	665	3	662	0.0e+00	1089	COG0021	Transketolase	663
644856505	129	53.49	1	128	3	128	1.0e-34	138	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
644856506	152	36.91	5	152	22	169	8.0e-31	126	COG2137	SOS response regulatory protein OraA/RecX, interacts with RecA	174
644856507	353	65.51	1	283	1	279	3.0e-88	319	COG0468	RecA/RadA recombinase	279
644856508	641	45.79	1	526	3	530	0.0e+00	546	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
644856509	205	37.25	1	204	3	203	2.0e-34	139	COG2095	Small neutral amino acid transporter SnatA, MarC family	203
644856513	334	54.4	1	312	3	314	9.0e-114	403	COG0180	Tryptophanyl-tRNA synthetase	314
644856514	224	44.75	6	224	5	217	2.0e-53	202	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
644856515	224	58.56	1	222	1	220	8.0e-88	316	COG0036	Pentose-5-phosphate-3-epimerase	220
644856516	98	53.33	7	96	24	113	8.0e-21	91.9	COG2919	Cell division protein FtsB	117
644856517	231	48.9	3	226	1	226	3.0e-69	255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	230
644856518	159	68.79	2	158	1	157	1.0e-66	245	COG0245	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	159
644856519	337	36.55	1	337	9	401	7.0e-87	314	COG0585	tRNA(Glu) U13 pseudouridine synthase TruD	406
644856520	246	55.95	1	244	1	252	9.0e-89	319	COG0496	Broad specificity polyphosphatase and 5'/3'-nucleotidase SurE	252
644856521	191	30.86	4	165	2	161	3.0e-28	118	COG1238	Uncharacterized membrane protein YqaA, SNARE-associated domain	161
644856523	402	32.22	145	401	1	263	6.0e-36	145	COG0739	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain	277
644856525	220	21.69	34	217	5	174	6.0e-22	97.7	COG3545	Predicted esterase of the alpha/beta hydrolase fold	181
644856526	114	30	1	109	1	110	1.0e-13	68.6	COG0789	DNA-binding transcriptional regulator, MerR family	124
644856528	463	17.23	2	448	6	382	3.0e-12	66.8	COG2814	Predicted arabinose efflux permease, MFS family	394
644856529	166	46.58	1	157	1	159	2.0e-44	172	COG1763	Molybdopterin-guanine dinucleotide biosynthesis protein	161
644856530	145	48.28	1	145	1	142	4.0e-43	166	COG3086	Positive regulator of sigma E activity	150
644856531	329	46.84	17	329	4	318	2.0e-108	386	COG3026	Negative regulator of sigma E activity	320
644856532	194	44.1	1	192	5	199	6.0e-51	193	COG3073	Negative regulator of sigma E activity	213
644856533	191	36.36	6	191	1	181	1.0e-32	132	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
644856534	84	38.96	1	77	10	86	6.0e-19	85.7	COG2938	Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module	94
644856537	571	48.42	1	567	1	500	0.0e+00	605	COG0442	Prolyl-tRNA synthetase	500
644856538	464	55.33	73	464	13	395	8.0e-118	417	COG1921	Seryl-tRNA(Sec) selenium transferase	395
644856539	619	44.16	1	455	1	447	7.0e-122	431	COG3276	Selenocysteine-specific translation elongation factor	447
644856541	367	35.54	1	352	3	358	2.0e-78	286	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
644856542	238	35	19	238	10	221	2.0e-44	172	COG1285	Uncharacterized membrane protein YhiD, involved in acid resistance	221
644856543	182	40.43	1	180	74	247	8.0e-45	173	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
644856544	499	39.07	6	455	4	438	6.0e-106	378	COG0733	Na+-dependent transporter, SNF family	439
644856546	544	31.31	2	543	1	541	3.0e-96	345	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
644856547	582	39.78	17	571	1	557	0.0e+00	605	COG4988	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components	559
644856548	440	58.22	4	440	1	436	0.0e+00	569	COG2704	Anaerobic C4-dicarboxylate transporter	436
644856549	146	32.11	38	146	1	109	1.0e-18	85.7	COG0607	Rhodanese-related sulfurtransferase	110
644856550	167	50	11	162	5	154	7.0e-52	196	COG1952	Preprotein translocase subunit SecB	157
644856551	337	53.33	8	337	2	329	5.0e-124	437	COG0240	Glycerol-3-phosphate dehydrogenase	329
644856552	265	53.12	72	263	2	193	2.0e-68	252	COG1045	Serine acetyltransferase	194
644856554	337	64.65	1	331	1	330	0.0e+00	476	COG1494	Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase or related protein	332
644856555	72	48.1	1	72	1	79	4.0e-08	49.7	COG3074	Cell division protein ZapB, interacts with FtsZ	79
644856556	147	28.67	4	146	3	150	7.0e-21	93.1	COG0716	Flavodoxin	151
644856557	629	67.04	3	626	1	621	0.0e+00	1008	COG0445	tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA	621
644856558	210	46.45	8	210	1	211	2.0e-57	215	COG0357	16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B)	215
644856559	124	32.26	1	122	1	124	8.0e-15	72.6	COG3312	FoF1-type ATP synthase assembly protein I	128
644856560	262	45.31	3	258	6	244	3.0e-51	195	COG0356	FoF1-type ATP synthase, membrane subunit a	246
644856562	156	46.75	3	156	5	158	4.0e-19	87.6	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	161
644856563	182	43.72	1	181	1	178	8.0e-39	153	COG0712	FoF1-type ATP synthase, delta subunit	178
644856564	513	65.5	1	513	1	502	0.0e+00	831	COG0056	FoF1-type ATP synthase, alpha subunit	504
644856565	289	56.99	5	289	1	286	5.0e-104	371	COG0224	FoF1-type ATP synthase, gamma subunit	287
644856566	457	77.63	1	457	1	465	0.0e+00	836	COG0055	FoF1-type ATP synthase, beta subunit	468
644856567	142	51.85	1	134	1	135	4.0e-34	136	COG0355	FoF1-type ATP synthase, epsilon subunit	135
644856569	352	38.53	1	349	2	334	4.0e-76	278	COG0859	ADP-heptose:LPS heptosyltransferase	334
644856570	307	31.97	1	307	2	310	1.0e-48	187	COG0451	Nucleoside-diphosphate-sugar epimerase	314
644856572	604	26.88	25	598	14	515	2.0e-71	263	COG0737	2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family	517
644856573	208	22.22	1	196	2	198	4.0e-08	51.6	COG1309	DNA-binding transcriptional regulator, AcrR family	201
644856574	298	31.31	1	295	1	293	1.0e-39	157	COG0583	DNA-binding transcriptional regulator, LysR family	297
644856575	242	49.33	171	242	2	76	5.0e-20	91.6	COG0695	Glutaredoxin	80
644856575	242	67.66	1	162	1	165	2.0e-69	255	COG0678	Peroxiredoxin	165
644856576	631	28.75	232	620	8	385	2.0e-87	316	COG0754	Glutathionylspermidine synthase	387
644856577	211	58.42	8	196	1	190	2.0e-71	262	COG3005	Tetraheme cytochrome c subunit of nitrate or TMAO reductase	190
644856578	149	54.3	1	149	5	155	4.0e-49	186	COG3043	Nitrate reductase cytochrome c-type subunit	155
644856580	291	25.84	52	140	7	89	1.0e-05	44.2	COG1145	Ferredoxin	99
644856581	826	30.25	2	826	1	764	0.0e+00	574	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
644856582	94	48.84	9	94	1	84	1.0e-20	91.1	COG3062	Cytoplasmic chaperone NapD for the signal peptide of periplasmic nitrate reductase NapAB	94
644856583	568	42.93	4	564	1	567	0.0e+00	585	COG3850	Signal transduction histidine kinase, nitrate/nitrite-specific	574
644856584	341	37.84	2	333	7	291	1.0e-86	313	COG0812	UDP-N-acetylenolpyruvoylglucosamine reductase	291
644856585	102	58	1	99	1	100	2.0e-32	130	COG4390	Uncharacterized protein	106
644856586	317	33.13	1	317	1	323	2.0e-40	160	COG1275	Tellurite resistance protein TehA and related permeases	329
644856587	282	38.46	2	281	55	332	3.0e-69	255	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
644856588	486	32.37	6	486	1	414	5.0e-96	345	COG2195	Di- or tripeptidase	414
644856589	179	17.07	26	169	14	177	2.0e-22	98.8	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	179
644856590	381	45.41	8	376	3	349	5.0e-105	375	COG1304	FMN-dependent dehydrogenase, includes L-lactate dehydrogenase and type II isopentenyl diphosphate isomerase	360
644856592	781	41.8	1	778	1	784	0.0e+00	644	COG1452	LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA)	784
644856593	188	54.01	3	188	2	188	4.0e-78	284	COG2818	3-methyladenine DNA glycosylase Tag	188
644856595	200	53.06	4	196	1	176	3.0e-46	178	COG3477	Uncharacterized membrane protein YagU, involved in acid resistance, DUF1440 family	176
644856596	416	50.51	1	391	1	394	4.0e-126	445	COG0019	Diaminopimelate decarboxylase	394
644856598	102	48.11	1	102	1	106	2.0e-29	120	COG1965	Iron-binding protein CyaY, frataxin homolog	106
644856599	631	57.72	32	624	5	588	0.0e+00	771	COG0514	Superfamily II DNA helicase RecQ	590
644856600	806	65.89	4	557	1	554	0.0e+00	933	COG0187	DNA gyrase/topoisomerase IV, subunit B	635
644856601	317	58.25	12	296	2	283	3.0e-101	361	COG1072	Panthothenate kinase	283
644856606	394	84.77	1	394	1	394	0.0e+00	725	COG0050	Translation elongation factor EF-Tu, a GTPase	394
644856607	255	60.33	1	242	2	236	5.0e-102	364	COG1126	ABC-type polar amino acid transport system, ATPase component	240
644856608	225	46.3	10	224	11	221	1.0e-56	213	COG0765	ABC-type amino acid transport system, permease component	222
644856609	259	34.94	3	259	1	269	2.0e-35	143	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
644856610	431	27.75	30	397	2	373	1.0e-66	247	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
644856611	73	66.2	3	73	2	72	3.0e-15	73	COG2900	Uncharacterized coiled-coil protein SlyX (sensitive to lysis X)	72
644856612	242	43.33	28	237	1	204	2.0e-48	185	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	205
644856613	222	60.18	6	221	1	220	4.0e-75	274	COG2964	Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains	220
644856614	125	46.03	1	125	1	126	7.0e-35	139	COG1553	Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family	126
644856615	120	50	1	120	1	118	5.0e-32	129	COG2923	Sulfur relay (sulfurtransferase) complex TusC component, DsrF/TusC family	118
644856616	95	33.67	1	95	1	96	1.0e-16	78.4	COG2168	Sulfur transfer complex TusBCD TusB component, DsrH family	96
644856617	343	30.62	76	329	2	247	6.0e-34	138	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
644856619	520	34.93	7	520	48	587	2.0e-100	360	COG0369	Sulfite reductase, alpha subunit (flavoprotein)	587
644856622	242	17.07	1	240	3	203	3.0e-18	85.8	COG0778	Nitroreductase	207
644856626	388	45.15	39	387	3	361	2.0e-86	312	COG0687	Spermidine/putrescine-binding periplasmic protein	363
644856628	249	46.59	75	249	5	174	3.0e-41	162	COG2110	O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain	179
644856629	280	21.83	6	251	1	216	5.0e-17	81.9	COG0846	NAD-dependent protein deacetylase, SIR2 family	250
644856630	282	29.71	4	269	1	275	2.0e-29	122	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
644856631	121	40.78	15	117	11	113	2.0e-24	104	COG1733	DNA-binding transcriptional regulator, HxlR family	120
644856633	301	79.93	3	301	1	297	0.0e+00	562	COG0752	Glycyl-tRNA synthetase, alpha subunit	298
644856638	688	58.47	1	688	1	690	0.0e+00	937	COG0751	Glycyl-tRNA synthetase, beta subunit	691
644856639	340	60.62	9	333	5	327	0.0e+00	529	COG0113	Delta-aminolevulinic acid dehydratase, porphobilinogen synthase	330
644856640	255	51.59	1	249	1	252	5.0e-67	247	COG0805	Sec-independent protein secretion pathway component TatC	255
644856641	217	41.58	1	101	1	93	4.0e-15	75	COG1826	Sec-independent protein translocase protein TatA	94
644856642	76	28	1	75	1	75	4.0e-11	59.6	COG1826	Sec-independent protein translocase protein TatA	94
644856643	213	38	14	213	3	202	2.0e-48	185	COG3165	Ubiquinone biosynthesis protein UbiJ, contains SCP2 domain	204
644856644	272	63.33	34	272	1	238	9.0e-91	326	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
644856646	290	48.95	6	285	2	286	4.0e-92	331	COG1281	Redox-regulated molecular chaperone, HSP33 family	286
644856647	137	62.11	9	103	5	99	2.0e-27	114	COG1188	Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain	100
644856648	218	19.73	8	217	1	222	9.0e-17	80.3	COG1011	FMN phosphatase YigB, HAD superfamily	229
644856651	208	46.6	1	206	2	182	2.0e-55	209	COG3059	Uncharacterized membrane protein YkgB	182
644856652	668	59.24	3	632	9	624	0.0e+00	642	COG1297	Uncharacterized membrane protein, oligopeptide transporter (OPT) family	624
644856654	269	38.91	1	268	1	275	2.0e-77	282	COG1218	3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase	276
644856655	494	53.27	3	486	5	483	0.0e+00	693	COG0364	Glucose-6-phosphate 1-dehydrogenase	483
644856656	232	36.36	1	232	1	236	9.0e-55	206	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	238
644856658	152	47.92	3	98	1	95	1.0e-28	118	COG3309	Virulence-associated protein VapD (function unknown)	96
644856659	484	63.92	4	476	3	473	0.0e+00	805	COG0362	6-phosphogluconate dehydrogenase	473
644856663	758	19.97	1	758	25	768	4.0e-43	170	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
644856664	235	58.65	1	235	1	237	4.0e-105	373	COG3700	Acid phosphatase (class B)	237
644856665	174	78.74	1	174	4	176	2.0e-78	284	COG5405	ATP-dependent protease HslVU (ClpYQ), peptidase subunit	178
644856666	105	40.95	1	105	2	105	1.0e-13	68.2	COG2076	Multidrug transporter EmrE and related cation transporters	106
644856667	443	75.23	1	443	1	444	0.0e+00	719	COG1220	ATP-dependent protease HslVU (ClpYQ), ATPase subunit	444
644856668	521	30.34	9	517	26	552	3.0e-73	269	COG0747	ABC-type transport system, periplasmic component	556
644856669	258	44.62	12	258	1	248	6.0e-77	281	COG2853	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, lipoprotein component MlaA	250
644856670	164	57.93	1	164	5	168	2.0e-65	241	COG3013	Uncharacterized protein YfbU, UPF0304 family	168
644856671	227	69.16	1	227	2	228	8.0e-105	373	COG0588	Phosphoglycerate mutase (BPG-dependent)	230
644856672	552	31.23	44	544	2	463	8.0e-87	315	COG1109	Phosphomannomutase	464
644856685	685	39.56	1	547	6	550	0.0e+00	524	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
644856686	88	40	1	84	10	94	3.0e-12	63.8	COG4104	Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, incolved in TypeVI secretion	98
644856687	862	39.06	13	857	2	781	0.0e+00	689	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
644856688	204	57.5	5	203	1	200	7.0e-76	276	COG0218	GTP-binding protein EngB required for normal cell division	200
644856689	291	42.23	1	289	5	299	3.0e-82	298	COG2990	Uncharacterized protein VirK/YbjX	300
644856690	158	61.94	1	154	2	155	2.0e-66	244	COG0219	tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain	155
644856691	165	36.09	1	163	23	171	1.0e-32	132	COG1881	Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family	174
644856692	280	49.82	1	280	1	268	5.0e-82	297	COG1464	ABC-type metal ion transport system, periplasmic component/surface antigen	268
644856693	225	54.95	4	225	1	222	2.0e-72	265	COG2011	ABC-type methionine transport system, permease component	222
644856694	345	61.05	1	343	1	339	0.0e+00	470	COG1135	ABC-type methionine transport system, ATPase component	339
644856695	198	51.61	1	185	4	181	5.0e-55	207	COG0241	Histidinol phosphatase or a related phosphatase	181
644856701	170	55.95	1	164	1	168	9.0e-55	206	COG0242	Peptide deformylase	168
644856702	318	52.94	3	307	1	301	2.0e-115	409	COG0223	Methionyl-tRNA formyltransferase	307
644856703	458	37.07	1	230	1	225	5.0e-47	182	COG0569	Trk K+ transport system, NAD-binding component	225
644856704	129	58.96	1	129	1	129	2.0e-37	147	COG1970	Large-conductance mechanosensitive channel	130
644856705	139	60.9	1	133	1	130	2.0e-38	151	COG3076	Regulator of RNase E activity RraB	135
644856706	240	33.33	7	238	3	235	7.0e-33	134	COG3471	Predicted secreted (periplasmic) protein	235
644856707	212	51.7	1	175	1	174	4.0e-49	188	COG1047	FKBP-type peptidyl-prolyl cis-trans isomerase 2	174
644856708	72	55.56	1	72	1	72	2.0e-13	67.6	COG2841	Uncharacterized conserved protein YdcH, DUF465 family	72
644856709	157	33.77	4	152	3	139	2.0e-30	124	COG0394	Protein-tyrosine-phosphatase	139
644856711	443	38.72	4	441	2	433	0.0e+00	478	COG0621	tRNA A37 methylthiotransferase MiaB	437
644856712	98	63.08	21	84	5	66	1.0e-15	74.7	COG3036	Stalled ribosome alternative rescue factor ArfA	66
644856714	116	36.21	1	116	1	115	3.0e-27	113	COG1393	Arsenate reductase and related proteins, glutaredoxin family	117
644856715	352	35.14	4	351	1	345	8.0e-40	158	COG0628	Predicted PurR-regulated permease PerM	355
644856716	252	58.57	1	251	3	247	3.0e-86	311	COG2820	Uridine phosphorylase	248
644856717	150	33.77	1	150	3	153	4.0e-27	114	COG1522	DNA-binding transcriptional regulator, Lrp family	154
644856718	291	74.14	2	291	41	330	0.0e+00	524	COG2502	Asparagine synthetase A	330
644856719	327	34.62	1	304	1	301	4.0e-81	294	COG0042	tRNA-dihydrouridine synthase	323
644856720	463	33.11	19	458	2	442	9.0e-59	221	COG0038	H+/Cl- antiporter ClcA	443
644856721	334	54.52	2	333	1	309	0.0e+00	460	COG0078	Ornithine carbamoyltransferase	310
644856722	310	59.42	1	301	1	312	1.0e-120	426	COG0549	Carbamate kinase	312
644856723	509	47.65	1	506	1	481	0.0e+00	526	COG1288	Uncharacterized membrane protein YfcC, ion transporter superfamily	481
644856724	155	40.65	1	155	1	154	3.0e-31	127	COG1522	DNA-binding transcriptional regulator, Lrp family	154
644856726	103	74.51	1	102	1	102	1.0e-38	151	COG0051	Ribosomal protein S10	104
644856727	208	65.09	1	208	1	212	5.0e-77	280	COG0087	Ribosomal protein L3	218
644856728	200	46.67	1	200	2	211	6.0e-55	206	COG0088	Ribosomal protein L4	214
644856729	100	58.51	6	98	1	94	1.0e-23	101	COG0089	Ribosomal protein L23	94
644856730	273	66.55	1	273	1	275	3.0e-110	391	COG0090	Ribosomal protein L2	275
644856731	91	71.43	1	91	1	91	3.0e-37	146	COG0185	Ribosomal protein S19	93
644856732	110	69.09	1	110	9	118	1.0e-34	137	COG0091	Ribosomal protein L22	120
644856733	235	63.88	12	235	1	227	1.0e-79	289	COG0092	Ribosomal protein S3	233
644856734	136	63.97	1	133	2	137	5.0e-47	179	COG0197	Ribosomal protein L16/L10AE	146
644856735	63	56.45	2	63	4	65	2.0e-09	53.7	COG0255	Ribosomal protein L29	69
644856736	85	55.95	1	84	4	87	3.0e-22	96.4	COG0186	Ribosomal protein S17	87
644856738	123	75.61	1	123	1	122	2.0e-49	187	COG0093	Ribosomal protein L14	122
644856739	103	51.43	1	103	1	103	4.0e-17	79.6	COG0198	Ribosomal protein L24	104
644856740	179	67.6	1	179	1	179	2.0e-80	291	COG0094	Ribosomal protein L5	180
644856741	101	67.21	41	101	1	61	4.0e-18	83	COG0199	Ribosomal protein S14	61
644856742	130	58.78	1	129	1	131	2.0e-45	174	COG0096	Ribosomal protein S8	132
644856743	177	55.37	1	176	1	176	2.0e-60	225	COG0097	Ribosomal protein L6P/L9E	178
644856744	117	50.83	1	117	6	125	5.0e-29	119	COG0256	Ribosomal protein L18	125
644856745	166	60.37	4	166	17	180	2.0e-57	215	COG0098	Ribosomal protein S5	181
644856746	144	52.67	1	144	1	150	1.0e-33	135	COG0200	Ribosomal protein L15	152
644856747	441	53.2	1	432	1	432	2.0e-130	459	COG0201	Preprotein translocase subunit SecY	436
644856748	118	66.39	1	118	1	119	7.0e-42	162	COG0099	Ribosomal protein S13	121
644856749	129	70.54	1	129	1	129	5.0e-50	189	COG0100	Ribosomal protein S11	129
644856750	206	63.94	1	206	1	205	4.0e-61	227	COG0522	Ribosomal protein S4 or related protein	205
644856751	329	59.75	8	323	1	313	3.0e-99	355	COG0202	DNA-directed RNA polymerase, alpha subunit/40 kD subunit	317
644856752	129	73.28	1	116	1	116	1.0e-47	181	COG0203	Ribosomal protein L17	116
644856753	253	21.37	1	249	2	257	1.0e-14	73.6	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
644856754	424	50	2	423	1	419	0.0e+00	493	COG1519	3-deoxy-D-manno-octulosonic-acid transferase	419
644856755	158	48.1	1	158	2	159	6.0e-58	216	COG0669	Phosphopantetheine adenylyltransferase	159
644856756	178	55.06	1	178	2	178	8.0e-60	222	COG2065	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	179
644856757	308	26.01	7	297	9	295	2.0e-16	80.1	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
644856758	287	50.94	11	274	4	259	3.0e-91	328	COG0030	16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity)	259
644856759	275	20	118	263	24	155	4.0e-11	62.4	COG0639	Diadenosine tetraphosphatase ApaH/serine/threonine protein phosphatase, PP2A family	155
644856760	154	48.43	2	153	16	174	2.0e-41	161	COG3981	Predicted acetyltransferase	174
644856762	862	53.35	1	859	1	814	0.0e+00	1101	COG0495	Leucyl-tRNA synthetase	814
644856763	167	52.17	2	161	1	161	1.0e-49	188	COG2980	Outer membrane lipoprotein LptE/RlpB (LPS assembly)	178
644856764	344	30.52	4	344	1	332	2.0e-52	200	COG1466	DNA polymerase III, delta subunit	334
644856766	134	31.39	1	132	6	139	9.0e-11	59.3	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
644856767	899	59.73	2	890	1	822	0.0e+00	1093	COG0653	Preprotein translocase subunit SecA (ATPase, RNA helicase)	822
644856770	138	35.34	1	115	1	116	9.0e-17	79.4	COG0789	DNA-binding transcriptional regulator, MerR family	124
644856771	943	69.57	1	942	3	935	0.0e+00	1613	COG0178	Excinuclease UvrABC ATPase subunit	935
644856772	158	44.31	2	158	1	167	6.0e-38	149	COG0629	Single-stranded DNA-binding protein	167
644856777	382	25.94	42	382	1	299	2.0e-26	113	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
644856778	301	25.83	4	301	2	297	4.0e-29	122	COG0583	DNA-binding transcriptional regulator, LysR family	297
644856779	243	24.71	1	241	3	256	5.0e-42	164	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
644856780	438	18.47	147	367	3	220	2.0e-08	54.1	COG0603	7-cyano-7-deazaguanine synthase (queuosine biosynthesis)	222
644856782	588	22.56	5	585	1	616	3.0e-46	180	COG4928	Predicted P-loop ATPase, KAP-like	646
644856788	279	39.93	18	279	5	267	4.0e-69	254	COG3384	Aromatic ring-opening dioxygenase, catalytic subunit, LigB family	268
644856789	122	35	25	122	6	105	2.0e-14	71.1	COG0607	Rhodanese-related sulfurtransferase	110
644856791	284	51.09	12	282	1	273	3.0e-73	268	COG0338	Site-specific DNA-adenine methylase	274
644856792	362	59.56	1	361	1	360	0.0e+00	503	COG0337	3-dehydroquinate synthetase	360
644856793	175	51.18	4	173	2	169	5.0e-55	206	COG0703	Shikimate kinase	172
644856799	281	65.71	2	281	1	279	1.0e-124	439	COG2961	23S rRNA A2030 N6-methylase RlmJ	279
644856801	456	39.7	1	456	1	454	6.0e-129	454	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
644856802	214	36.95	13	214	13	214	5.0e-39	154	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
644856803	72	55.56	1	72	1	72	3.0e-21	93.1	COG3089	Uncharacterized conserved protein YheU, UPF0270 family	72
644856804	199	23.46	1	178	1	175	1.0e-06	46.6	COG1309	DNA-binding transcriptional regulator, AcrR family	201
644856805	151	54.3	1	151	1	148	2.0e-53	201	COG0756	dUTPase	148
644856806	399	51.64	3	398	1	392	2.0e-120	425	COG0452	Phosphopantothenoylcysteine synthetase/decarboxylase	392
644856807	219	54.38	3	219	8	224	7.0e-75	273	COG2003	DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif	224
644856808	78	64.94	1	76	1	77	4.0e-22	96.5	COG0227	Ribosomal protein L28	77
644856809	56	58	5	54	1	50	2.0e-10	57.1	COG0267	Ribosomal protein L33	50
644856810	271	52.38	1	269	1	273	8.0e-100	356	COG0266	Formamidopyrimidine-DNA glycosylase	273
644856811	353	20.77	35	349	10	334	1.0e-17	84.3	COG0859	ADP-heptose:LPS heptosyltransferase	334
644856812	337	21.32	27	337	1	328	3.0e-30	125	COG0859	ADP-heptose:LPS heptosyltransferase	334
644856813	228	26.27	7	217	2	215	1.0e-26	113	COG3306	Glycosyltransferase involved in LPS biosynthesis, GR25 family	255
644856814	70	61.64	1	70	1	73	4.0e-22	96.1	COG0254	Ribosomal protein L31	75
644856815	282	35.71	7	268	4	255	3.0e-49	189	COG3306	Glycosyltransferase involved in LPS biosynthesis, GR25 family	255
644856817	239	37.72	8	235	1	223	6.0e-44	171	COG4750	CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epi...	231
644856819	305	30.25	31	301	1	267	8.0e-31	127	COG0510	Thiamine kinase and related kinases	269
644856821	732	45.75	1	731	1	730	0.0e+00	833	COG1198	Primosomal protein N' (replication factor Y) - superfamily II helicase	730
644856822	280	30.55	12	280	1	262	1.0e-26	113	COG3087	Cell division protein FtsN	264
644856823	188	15.64	10	188	15	191	7.0e-10	57.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
644856824	398	28.28	47	316	32	321	2.0e-26	113	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
644856825	1032	38.74	2	1010	1	1007	0.0e+00	870	COG0841	Multidrug efflux pump subunit AcrB	1009
644856828	315	34.37	1	315	4	322	8.0e-66	244	COG0598	Mg2+ and Co2+ transporter CorA	322
644856829	186	28.72	91	183	3	96	7.0e-08	50.6	COG0762	Uncharacterized conserved protein YggT, Ycf19 family	96
644856830	97	45	1	96	3	102	2.0e-22	97.3	COG1872	Uncharacterized conserved protein YggU, UPF0235/DUF167 family	102
644856832	219	26.39	7	219	4	206	5.0e-33	134	COG0778	Nitroreductase	207
644856833	657	26.56	5	648	4	646	3.0e-94	340	COG1368	Phosphoglycerol transferase MdoB or a related enzyme of AlkP superfamily	650
644856834	191	31.75	6	191	5	184	7.0e-23	100	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	189
644856835	244	51.6	1	244	1	249	1.0e-82	299	COG1496	Copper oxidase (laccase) domain	249
644856836	324	46.69	6	302	2	289	2.0e-79	289	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
644856837	264	39.77	2	256	1	249	4.0e-59	221	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	254
644856838	192	41.53	9	189	3	181	3.0e-46	178	COG0212	5-formyltetrahydrofolate cyclo-ligase	191
644856839	102	40.62	3	98	1	95	1.0e-14	71.5	COG3027	Cell division protein ZapA, inhibits GTPase activity of FtsZ	105
644856840	182	54.05	1	182	3	186	4.0e-59	220	COG3079	Uncharacterized conserved protein YgfB, UPF0149 family	186
644856841	433	30.26	10	425	6	384	5.0e-70	258	COG0006	Xaa-Pro aminopeptidase	384
644856842	414	34.38	2	414	1	385	3.0e-75	275	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
644856843	82	62.2	1	82	1	81	3.0e-28	116	COG0228	Ribosomal protein S16	87
644856844	175	51.7	1	175	2	172	2.0e-53	201	COG0806	Ribosomal 30S subunit maturation factor RimM, required for 16S rRNA processing	174
644856845	250	59.5	1	241	1	240	9.0e-111	392	COG0336	tRNA G37 N-methylase TrmD	240
644856846	116	69.64	3	114	4	115	2.0e-41	160	COG0335	Ribosomal protein L19	115
644856848	353	37.41	3	271	1	270	8.0e-66	244	COG1792	Cell shape-determining protein MreC	284
644856849	351	65.2	7	348	2	341	5.0e-127	447	COG1077	Actin-like ATPase involved in cell morphogenesis	342
644856851	801	48.88	24	734	2	706	0.0e+00	771	COG0557	Exoribonuclease R	706
644856852	245	46.94	1	245	20	259	3.0e-67	248	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
644856854	480	49.06	1	477	1	448	0.0e+00	539	COG2271	Sugar phosphate permease	448
644856855	360	36.06	30	359	5	257	1.0e-42	167	COG0584	Glycerophosphoryl diester phosphodiesterase	257
644856856	492	40.46	19	362	1	338	7.0e-123	434	COG0059	Ketol-acid reductoisomerase	338
644856857	292	28.42	1	291	1	287	5.0e-35	141	COG0583	DNA-binding transcriptional regulator, LysR family	297
644856858	293	33.57	1	283	5	286	1.0e-55	210	COG2962	Uncharacterized membrane protein RarD, contains two EamA domains	293
644856859	266	37	1	266	7	277	8.0e-67	247	COG0169	Shikimate 5-dehydrogenase	283
644856860	183	35.98	3	183	16	197	6.0e-41	160	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
644856861	194	36.51	69	194	14	138	2.0e-22	98.7	COG0551	ssDNA-binding Zn-finger and Zn-ribbon domains of topoisomerase 1	140
644856862	538	33.33	69	538	1	446	4.0e-83	302	COG1322	DNA anti-recombination protein (rearrangement mutator) RmuC	448
644856863	108	36.04	1	108	1	110	4.0e-16	76.5	COG0607	Rhodanese-related sulfurtransferase	110
644856865	289	25.62	103	288	13	215	6.0e-22	98.3	COG0705	Membrane associated serine protease, rhomboid family	228
644856866	251	38.49	1	251	1	252	9.0e-69	253	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
644856867	924	14.15	68	877	85	754	2.0e-18	88.8	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
644856875	607	23.68	217	604	124	498	1.0e-43	171	COG3378	Phage- or plasmid-associated DNA primase	517
644856879	122	34.91	14	119	27	131	2.0e-15	74.7	COG5566	Transcriptional regulator, Middle operon regulator (Mor) family	137
644856881	413	19.17	93	398	1	303	3.0e-06	46.9	COG0582	Integrase	309
644856883	623	49.03	266	622	1	342	1.0e-98	354	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
644856884	598	43.79	5	579	2	560	0.0e+00	497	COG0358	DNA primase (bacterial type)	568
644856885	71	58.21	1	67	1	67	2.0e-07	47.2	COG0828	Ribosomal protein S21	67
644856887	342	58.31	1	342	1	340	0.0e+00	480	COG0533	tRNA A37 threonylcarbamoyltransferase TsaD	342
644856889	192	50.26	1	192	3	195	2.0e-75	275	COG1435	Thymidine kinase	201
644856890	671	58.45	2	670	4	667	0.0e+00	968	COG0272	NAD-dependent DNA ligase	667
644856891	338	30.32	1	337	2	316	9.0e-62	230	COG3115	Cell division protein ZipA, interacts with FtsZ	324
644856892	276	51.65	3	244	1	242	1.0e-72	266	COG2981	Uncharacterized protein involved in cysteine biosynthesis	250
644856893	315	55.66	3	307	1	300	5.0e-103	367	COG0031	Cysteine synthase	300
644856894	193	25	1	190	7	202	1.0e-44	172	COG1573	Uracil-DNA glycosylase	202
644856896	363	64.78	1	363	1	372	0.0e+00	541	COG0012	Ribosome-binding ATPase YchF, GTP1/OBG family	372
644856897	194	61.26	3	193	1	190	6.0e-73	267	COG0193	Peptidyl-tRNA hydrolase	190
644856898	125	70.25	5	125	45	165	6.0e-43	165	COG1666	Uncharacterized conserved protein YajQ, UPF0234 family	165
644856900	314	50.72	103	308	6	212	5.0e-62	231	COG0560	Phosphoserine phosphatase	212
644856901	225	35.38	1	195	1	190	2.0e-42	165	COG3726	Uncharacterized membrane protein affecting hemolysin expression	214
644856902	87	64.37	1	87	1	87	8.0e-12	61.8	COG0268	Ribosomal protein S20	88
644856903	523	46.95	1	519	5	514	2.0e-116	412	COG0728	Peptidoglycan biosynthesis protein MviN/MurJ, putative lipid II flippase	518
644856904	339	46.71	1	334	1	304	2.0e-99	355	COG0196	FAD synthase	304
644856905	940	52.32	2	934	1	933	0.0e+00	1305	COG0060	Isoleucyl-tRNA synthetase	933
644856906	164	45.51	1	164	3	165	9.0e-38	149	COG0597	Lipoprotein signal peptidase	167
644856907	314	69.83	1	295	2	294	1.0e-128	452	COG0761	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH	294
644856909	108	39.62	3	108	45	149	8.0e-15	72	COG1555	DNA uptake protein ComE and related DNA-binding proteins	149
644856910	223	54.82	26	221	1	190	4.0e-63	234	COG0127	Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family	194
644856911	107	57.01	1	107	1	106	5.0e-27	112	COG0393	Uncharacterized conserved protein YbjQ, UPF0145 family	108
644856912	384	43.64	8	382	34	410	4.0e-114	404	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
644856913	218	57.52	1	218	1	225	7.0e-76	277	COG0120	Ribose 5-phosphate isomerase	227
644856914	410	43.07	9	337	1	324	2.0e-90	326	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
644856915	275	52.94	1	275	1	289	4.0e-98	351	COG2321	Predicted metalloprotease	295
644856917	198	45	1	193	1	200	4.0e-54	204	COG0344	Phospholipid biosynthesis protein PlsY, probable glycerol-3-phosphate acyltransferase	200
644856918	119	46.67	1	119	1	120	1.0e-32	131	COG1539	Dihydroneopterin aldolase	121
644856919	487	58.05	21	459	1	441	0.0e+00	614	COG4623	Membrane-bound lytic murein transglycosylase MltF	473
644856921	179	39.77	1	168	1	169	1.0e-25	109	COG1495	Disulfide bond formation protein DsbB	170
644856922	516	73.35	5	516	3	516	0.0e+00	774	COG3067	Na+/H+ antiporter NhaB	516
644856923	241	26.38	8	233	3	236	1.0e-37	149	COG2186	DNA-binding transcriptional regulator, FadR family	241
644856924	404	36.88	8	402	1	392	4.0e-99	355	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
644856925	435	34.99	8	424	1	421	2.0e-98	353	COG1169	Isochorismate synthase EntC	423
644856926	568	46.17	1	566	1	566	0.0e+00	682	COG1165	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	566
644856927	249	24.15	2	243	21	280	1.0e-17	84	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
644856928	89	59.55	1	89	1	89	5.0e-26	109	COG0184	Ribosomal protein S15P/S13E	89
644856929	384	70.54	1	383	2	388	0.0e+00	691	COG0192	S-adenosylmethionine synthetase	388
644856931	155	40.91	1	154	1	153	8.0e-40	156	COG3091	Predicted Zn-dependent metalloprotease, SprT family	156
644856932	412	36.25	6	412	5	412	2.0e-75	276	COG0814	Amino acid permease	415
644856933	408	52.48	123	404	1	262	1.0e-88	320	COG1760	L-serine deaminase	262
