gene_oid	gene_length	percent_identity	query_start	query_end	subj_start	subj_end	evalue	bit_score	cog_id	cog_name	cog_length
643871441	461	53.54	6	457	1	408	0.0e+00	489	COG0593	Chromosomal replication initiation ATPase DnaA	408
643871442	367	42.66	1	367	1	364	1.0e-92	333	COG0592	DNA polymerase III sliding clamp (beta) subunit, PCNA homolog	364
643871443	357	38.57	2	357	3	363	2.0e-87	316	COG1195	Recombinational DNA repair ATPase RecF	363
643871444	805	63.94	1	560	1	559	0.0e+00	899	COG0187	DNA gyrase/topoisomerase IV, subunit B	635
643871445	337	28.05	5	319	18	342	6.0e-47	181	COG0687	Spermidine/putrescine-binding periplasmic protein	363
643871446	808	44.92	555	807	2	255	1.0e-66	248	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
643871447	413	60.29	1	413	1	412	0.0e+00	593	COG3977	Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase	417
643871448	690	54.99	1	689	1	690	0.0e+00	894	COG0751	Glycyl-tRNA synthetase, beta subunit	691
643871449	304	78.6	3	301	1	297	0.0e+00	562	COG0752	Glycyl-tRNA synthetase, alpha subunit	298
643871450	191	54.26	1	187	1	187	4.0e-70	257	COG2818	3-methyladenine DNA glycosylase Tag	188
643871451	338	26.9	50	337	32	321	2.0e-51	196	COG0598	Mg2+ and Co2+ transporter CorA	322
643871452	333	64.09	13	333	26	348	0.0e+00	475	COG1613	ABC-type sulfate transport system, periplasmic component	348
643871453	175	36.05	1	165	2	173	8.0e-33	133	COG3545	Predicted esterase of the alpha/beta hydrolase fold	181
643871454	278	52.57	4	275	4	274	2.0e-70	259	COG0555	ABC-type sulfate transport system, permease component	274
643871455	271	65.02	5	267	13	275	2.0e-99	355	COG4208	ABC-type sulfate transport system, permease component	287
643871456	361	55.31	1	355	1	345	2.0e-111	395	COG1118	ABC-type sulfate/molybdate transport systems, ATPase component	345
643871457	318	30.2	1	296	1	292	3.0e-36	145	COG0583	DNA-binding transcriptional regulator, LysR family	297
643871458	82	45.33	7	80	3	77	1.0e-21	94.6	COG0425	TusA-related sulfurtransferase	78
643871459	417	19.35	7	417	12	431	1.0e-26	114	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
643871460	469	25.4	168	468	20	329	2.0e-31	130	COG0642	Signal transduction histidine kinase	336
643871461	240	46.32	7	235	3	228	8.0e-60	223	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
643871462	174	50.58	4	173	2	172	7.0e-48	183	COG4635	Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain)	175
643871470	239	30.7	11	238	18	226	5.0e-17	81.6	COG2801	Transposase InsO and inactivated derivatives	232
643871471	114	30.56	8	114	3	104	1.0e-06	45.2	COG2963	Transposase and inactivated derivatives	116
643871472	361	18.9	16	359	6	376	2.0e-16	80.4	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
643871473	344	25.85	62	344	88	378	4.0e-27	115	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
643871474	261	18.15	6	254	4	259	1.0e-12	67.5	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
643871475	355	31.94	11	292	4	288	9.0e-55	207	COG0859	ADP-heptose:LPS heptosyltransferase	334
643871476	341	34.88	1	341	1	329	9.0e-71	260	COG0859	ADP-heptose:LPS heptosyltransferase	334
643871477	416	20.35	11	402	27	415	9.0e-17	81.7	COG3307	O-antigen ligase	424
643871478	317	31.48	1	317	2	310	7.0e-45	174	COG0451	Nucleoside-diphosphate-sugar epimerase	314
643871479	369	52.25	1	356	1	338	7.0e-122	430	COG3839	ABC-type sugar transport system, ATPase component	338
643871481	411	57.97	1	411	1	429	2.0e-130	459	COG4580	Maltoporin (phage lambda and maltose receptor)	429
643871482	369	51.4	1	356	1	338	1.0e-118	419	COG3839	ABC-type sugar transport system, ATPase component	338
643871483	393	38.79	7	393	16	412	2.0e-99	356	COG2182	Maltose-binding periplasmic protein MalE	420
643871484	528	36.36	261	523	41	288	7.0e-50	191	COG1175	ABC-type sugar transport system, permease component	295
643871485	296	52.84	1	296	1	282	2.0e-81	295	COG3833	ABC-type maltose transport system, permease component	282
643871487	110	25.77	8	104	2	97	9.0e-14	68.5	COG3668	Plasmid stabilization system protein ParE	98
643871488	319	36.29	58	309	9	252	6.0e-41	161	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
643871489	706	39.68	130	695	1	520	0.0e+00	535	COG1640	4-alpha-glucanotransferase	520
643871490	811	45.56	14	808	5	747	0.0e+00	808	COG0058	Glucan phosphorylase	750
643871491	906	49.72	1	903	6	894	0.0e+00	851	COG2909	ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT	894
643871492	304	37.58	1	304	7	310	6.0e-58	217	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
643871493	246	39.24	4	239	2	228	3.0e-53	202	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
643871494	341	26.89	8	335	2	310	1.0e-34	140	COG0524	Sugar or nucleoside kinase, ribokinase family	311
643871495	286	47.22	1	286	1	286	5.0e-92	330	COG0191	Fructose/tagatose bisphosphate aldolase	286
643871496	229	59.21	1	227	1	225	2.0e-76	278	COG3822	D-lyxose ketol-isomerase	225
643871497	481	41.8	1	474	5	492	1.0e-118	420	COG1070	Sugar (pentulose or hexulose) kinase	502
643871498	313	37.11	1	313	7	321	1.0e-47	183	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
643871499	333	73.56	5	333	1	329	3.0e-109	388	COG4158	Predicted ABC-type sugar transport system, permease component	329
643871500	507	53.71	1	497	2	500	0.0e+00	643	COG1129	ABC-type sugar transport system, ATPase component	500
643871502	82	45.88	1	82	1	78	3.0e-07	47	COG4238	Outer membrane murein-binding lipoprotein Lpp	78
643871503	307	33.75	4	237	2	232	1.0e-35	143	COG1376	Lipoprotein-anchoring transpeptidase ErfK/SrfK	232
643871504	1130	43.27	1	1128	1	1078	0.0e+00	910	COG1330	Exonuclease V gamma subunit	1078
643871505	1175	37.49	5	1134	8	1139	0.0e+00	751	COG1074	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)	1139
643871506	632	29.11	13	626	37	696	8.0e-100	358	COG0507	ATP-dependent exoDNAse (exonuclease V), alpha subunit, helicase superfamily I	696
643871507	297	48.3	9	295	1	291	1.0e-82	299	COG0685	5,10-methylenetetrahydrofolate reductase	291
643871508	384	41.13	23	384	88	459	7.0e-92	331	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
643871509	165	23.89	31	143	14	126	2.0e-09	54.9	COG1846	DNA-binding transcriptional regulator, MarR family	126
643871510	489	42.62	1	469	29	507	4.0e-120	425	COG0513	Superfamily II DNA and RNA helicase	513
643871511	469	36.36	12	467	28	483	7.0e-110	391	COG0513	Superfamily II DNA and RNA helicase	513
643871512	253	42.69	1	253	1	252	9.0e-71	260	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643871513	513	45.28	8	513	13	526	0.0e+00	526	COG0578	Glycerol-3-phosphate dehydrogenase	532
643871514	497	70.08	1	497	1	498	0.0e+00	825	COG0554	Glycerol kinase	499
643871516	317	38.79	1	312	1	326	1.0e-57	217	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
643871517	202	39.25	10	191	2	185	6.0e-34	137	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
643871518	677	36.41	1	561	5	547	3.0e-121	429	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
643871522	186	30.27	1	184	2	176	5.0e-39	154	COG0663	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily	176
643871523	368	34.48	13	356	1	319	9.0e-62	230	COG0523	GTPase, G3E family	323
643871525	146	21.33	4	142	2	151	6.0e-08	50.4	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
643871526	620	39.05	1	397	3	396	3.0e-64	240	COG0475	Kef-type K+ transport system, membrane component KefB	397
643871527	198	31.94	2	177	1	189	2.0e-32	132	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	189
643871528	688	51.61	1	681	1	681	0.0e+00	861	COG1770	Protease II	682
643871529	99	27.47	8	96	8	98	6.0e-11	59.2	COG3691	Uncharacterized conserved protein YfcZ, UPF0381/DUF406 family	98
643871530	199	40.38	1	199	3	207	7.0e-37	146	COG0655	Multimeric flavodoxin WrbA	207
643871531	123	35.48	6	65	3	64	2.0e-10	58.3	COG1983	Phage shock protein PspC (stress-responsive transcriptional regulator)	70
643871533	224	37.27	1	217	1	220	5.0e-23	101	COG1842	Phage shock protein A	225
643871537	195	40.61	1	194	5	201	1.0e-33	136	COG2095	Small neutral amino acid transporter SnatA, MarC family	203
643871538	877	51.1	2	877	3	910	0.0e+00	1071	COG2352	Phosphoenolpyruvate carboxylase	910
643871539	381	32.25	5	380	14	407	9.0e-65	241	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
643871540	335	48.55	1	334	2	342	4.0e-110	391	COG0002	N-acetyl-gamma-glutamylphosphate reductase	349
643871541	260	39.85	6	258	4	263	2.0e-53	202	COG0548	Acetylglutamate kinase	265
643871542	303	46.56	1	301	6	310	1.0e-96	346	COG0078	Ornithine carbamoyltransferase	310
643871543	461	55.8	1	457	3	458	0.0e+00	608	COG0165	Argininosuccinate lyase	459
643871544	103	74.51	1	102	1	102	1.0e-38	151	COG0051	Ribosomal protein S10	104
643871545	212	60.38	2	212	1	212	1.0e-77	282	COG0087	Ribosomal protein L3	218
643871546	201	47.62	1	201	2	211	2.0e-55	208	COG0088	Ribosomal protein L4	214
643871547	101	62.77	7	99	1	94	9.0e-24	101	COG0089	Ribosomal protein L23	94
643871548	273	65.45	1	273	1	275	4.0e-108	384	COG0090	Ribosomal protein L2	275
643871549	92	70.65	1	92	1	92	2.0e-37	147	COG0185	Ribosomal protein S19	93
643871550	115	62.16	2	112	9	119	2.0e-32	131	COG0091	Ribosomal protein L22	120
643871551	238	62.28	12	236	1	228	6.0e-79	287	COG0092	Ribosomal protein S3	233
643871552	137	66.18	1	134	2	137	6.0e-48	183	COG0197	Ribosomal protein L16/L10AE	146
643871553	63	56.45	2	63	4	65	3.0e-10	56.4	COG0255	Ribosomal protein L29	69
643871554	82	56.1	1	82	4	85	1.0e-23	101	COG0186	Ribosomal protein S17	87
643871555	122	73.77	1	122	1	122	4.0e-50	189	COG0093	Ribosomal protein L14	122
643871556	105	51.89	1	104	1	103	2.0e-16	77.3	COG0198	Ribosomal protein L24	104
643871557	179	67.6	1	179	1	179	4.0e-79	287	COG0094	Ribosomal protein L5	180
643871558	101	65.57	41	101	1	61	5.0e-19	86	COG0199	Ribosomal protein S14	61
643871559	130	60.31	1	129	1	131	7.0e-45	172	COG0096	Ribosomal protein S8	132
643871560	177	54.24	1	176	1	176	2.0e-54	204	COG0097	Ribosomal protein L6P/L9E	178
643871561	117	53.33	1	117	6	125	3.0e-27	113	COG0256	Ribosomal protein L18	125
643871562	166	59.28	1	166	14	180	2.0e-57	214	COG0098	Ribosomal protein S5	181
643871563	60	60	6	60	1	55	3.0e-14	69.8	COG1841	Ribosomal protein L30/L7E	55
643871564	144	52.67	1	144	1	150	4.0e-27	113	COG0200	Ribosomal protein L15	152
643871565	443	53.12	1	429	1	427	1.0e-123	437	COG0201	Preprotein translocase subunit SecY	436
643871567	118	68.07	1	118	1	119	3.0e-42	163	COG0099	Ribosomal protein S13	121
643871568	129	69.77	1	129	1	129	5.0e-49	186	COG0100	Ribosomal protein S11	129
643871569	206	63.94	1	206	1	205	9.0e-61	226	COG0522	Ribosomal protein S4 or related protein	205
643871570	329	57.41	8	323	1	313	7.0e-97	347	COG0202	DNA-directed RNA polymerase, alpha subunit/40 kD subunit	317
643871571	128	71.55	1	116	1	116	8.0e-48	182	COG0203	Ribosomal protein L17	116
643871572	195	28.89	2	177	5	181	2.0e-17	82.3	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
643871573	106	77.45	5	106	4	105	2.0e-44	170	COG3060	Transcriptional regulator of met regulon	105
643871574	386	53.59	3	381	5	393	0.0e+00	475	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
643871575	812	31.64	12	458	3	447	2.0e-78	287	COG0527	Aspartokinase	447
643871576	93	56.58	7	82	6	81	4.0e-23	99.5	COG1254	Acylphosphatase	92
643871577	276	53.48	1	270	1	273	6.0e-93	334	COG0266	Formamidopyrimidine-DNA glycosylase	273
643871578	164	56.69	1	157	1	157	1.0e-59	222	COG0669	Phosphopantetheine adenylyltransferase	159
643871582	435	46.65	18	430	1	415	2.0e-129	456	COG1519	3-deoxy-D-manno-octulosonic-acid transferase	419
643871583	371	40.39	20	369	2	360	5.0e-65	241	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	366
643871584	306	48.34	5	305	3	297	1.0e-59	223	COG0559	Branched-chain amino acid ABC-type transport system, permease component	297
643871585	415	50.62	94	408	11	309	3.0e-57	216	COG4177	ABC-type branched-chain amino acid transport system, permease component	314
643871586	254	60.08	1	253	1	250	1.0e-100	359	COG0411	ABC-type branched-chain amino acid transport system, ATPase component	250
643871587	235	63.4	1	235	3	237	8.0e-96	343	COG0410	ABC-type branched-chain amino acid transport system, ATPase component	237
643871588	106	28	1	97	1	100	2.0e-17	81.1	COG0607	Rhodanese-related sulfurtransferase	110
643871589	276	26.82	99	268	32	210	7.0e-16	77.8	COG0705	Membrane associated serine protease, rhomboid family	228
643871590	173	28.49	12	171	7	171	9.0e-12	63.4	COG3161	4-hydroxybenzoate synthetase (chorismate-pyruvate lyase)	174
643871591	286	43.9	1	286	2	288	6.0e-51	194	COG0382	4-hydroxybenzoate polyprenyltransferase	289
643871592	206	47.29	1	202	1	199	3.0e-55	208	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	201
643871593	154	58.06	1	154	2	155	1.0e-60	225	COG0219	tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain	155
643871594	151	38.24	1	134	1	136	1.0e-27	116	COG1959	DNA-binding transcriptional regulator, IscR family	150
643871595	480	36.84	3	480	2	488	8.0e-83	301	COG0168	Trk-type K+ transport system, membrane component	499
643871596	458	38.79	1	230	1	225	1.0e-46	181	COG0569	Trk K+ transport system, NAD-binding component	225
643871597	433	40.73	89	429	1	353	5.0e-87	315	COG0144	16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family	355
643871598	314	56.29	3	304	1	302	7.0e-116	410	COG0223	Methionyl-tRNA formyltransferase	307
643871599	167	51.79	1	164	1	168	2.0e-55	208	COG0242	Peptide deformylase	168
643871601	374	38.15	10	372	1	350	6.0e-93	334	COG0758	Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake	350
643871602	157	59.21	1	152	1	152	1.0e-46	178	COG2922	Uncharacterized conserved protein Smg, DUF494 family	157
643871603	190	38.35	59	190	8	138	2.0e-20	92.5	COG0551	ssDNA-binding Zn-finger and Zn-ribbon domains of topoisomerase 1	140
643871604	167	52.47	4	165	3	162	3.0e-45	174	COG0041	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	162
643871605	186	41.08	5	186	16	197	3.0e-52	197	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
643871606	273	41.22	1	272	6	283	2.0e-74	272	COG0169	Shikimate 5-dehydrogenase	283
643871607	180	46.37	1	179	1	172	2.0e-51	195	COG0663	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily	176
643871615	724	23.51	217	468	53	308	6.0e-21	96.8	COG1262	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain	314
643871616	135	41.73	11	134	7	133	6.0e-34	136	COG0295	Cytidine deaminase	134
643871617	554	44.17	12	518	1	494	4.0e-116	412	COG0366	Glycosidase	505
643871618	478	27.46	96	478	1	391	1.0e-66	247	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
643871619	315	31.89	6	315	2	323	3.0e-59	222	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643871620	168	31.58	1	164	1	154	1.0e-22	99.2	COG2731	Beta-galactosidase, beta subunit	154
643871621	220	25.73	12	208	7	210	3.0e-21	95.7	COG0625	Glutathione S-transferase	211
643871622	422	63.98	1	422	6	425	0.0e+00	633	COG2873	O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent	426
643871623	482	19.95	16	419	16	362	5.0e-15	76.4	COG2814	Predicted arabinose efflux permease, MFS family	394
643871624	262	42.79	57	256	18	218	8.0e-49	187	COG0765	ABC-type amino acid transport system, permease component	222
643871625	277	29.64	5	275	3	267	2.0e-27	116	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
643871626	523	67.96	1	511	1	515	0.0e+00	720	COG3067	Na+/H+ antiporter NhaB	516
643871627	297	34.1	1	297	7	297	3.0e-51	195	COG2040	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)	300
643871629	567	26.85	89	235	4	147	2.0e-06	48.2	COG3650	Uncharacterized membrane protein	149
643871630	266	35.21	1	266	2	264	5.0e-52	198	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
643871631	715	44.35	1	704	6	701	0.0e+00	874	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	701
643871632	94	60.32	1	62	1	63	1.0e-12	64.9	COG1758	DNA-directed RNA polymerase, subunit K/omega	74
643871633	209	55.85	5	192	4	187	4.0e-75	274	COG0194	Guanylate kinase	191
643871634	55	52	4	53	1	50	9.0e-11	58.7	COG0267	Ribosomal protein L33	50
643871635	78	61.04	1	76	1	77	6.0e-20	88.8	COG0227	Ribosomal protein L28	77
643871636	224	52.68	1	224	1	224	4.0e-80	291	COG2003	DNA repair protein RadC, contains a helix-hairpin-helix DNA-binding motif	224
643871637	409	52.76	10	405	2	392	9.0e-120	423	COG0452	Phosphopantothenoylcysteine synthetase/decarboxylase	392
643871638	151	54.3	1	151	1	148	1.0e-53	202	COG0756	dUTPase	148
643871639	213	41.04	3	211	1	201	3.0e-51	195	COG0461	Orotate phosphoribosyltransferase	201
643871640	237	58.82	1	237	8	230	6.0e-81	293	COG0689	Ribonuclease PH	230
643871641	286	52.76	1	286	1	290	5.0e-87	314	COG1561	Uncharacterized conserved protein YicC, UPF0701 family	290
643871642	430	43.63	2	406	4	400	5.0e-88	318	COG1301	Na+/H+-dicarboxylate symporter	415
643871643	369	36.2	199	359	20	181	1.0e-27	117	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643871648	154	44.16	1	153	1	154	4.0e-33	133	COG2606	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC	155
643871649	93	64.52	1	92	1	93	2.0e-34	136	COG3123	Uncharacterized conserved protein YaiE, UPF0345 family	94
643871651	164	33.94	2	164	4	166	1.0e-37	148	COG3516	Predicted component of the type VI protein secretion system	169
643871652	491	54.67	2	491	6	493	0.0e+00	705	COG3517	Predicted component of the type VI protein secretion system	495
643871653	137	32	5	119	14	138	6.0e-16	76.9	COG3518	Predicted component of the type VI protein secretion system	157
643871654	585	34.72	1	584	3	620	1.0e-120	427	COG3519	Type VI protein secretion system component VasA	621
643871655	339	34.47	18	331	16	328	3.0e-62	232	COG3520	Predicted component of the type VI protein secretion system	335
643871656	869	40.68	13	857	2	771	0.0e+00	734	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
643871659	431	23.79	1	417	1	423	1.0e-46	180	COG3456	Predicted component of the type VI protein secretion system, contains a FHA domain	430
643871660	183	41.18	14	129	17	135	2.0e-27	115	COG3521	Predicted component of the type VI protein secretion system	159
643871661	447	40.98	2	446	5	446	9.0e-112	397	COG3522	Predicted component of the type VI protein secretion system	446
643871662	288	38.14	43	277	24	256	7.0e-49	187	COG3455	Type VI protein secretion system component VasF	262
643871663	1173	31.72	15	1173	12	1187	0.0e+00	680	COG3523	Type VI protein secretion system component VasK	1188
643871664	244	35.22	10	244	8	252	7.0e-47	180	COG0631	Serine/threonine protein phosphatase PrpC	262
643871666	703	34.86	24	566	9	539	5.0e-122	432	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
643871667	536	51.53	3	522	1	517	0.0e+00	576	COG2918	Gamma-glutamylcysteine synthetase	518
643871668	225	29.7	2	196	1	200	1.0e-35	143	COG0625	Glutathione S-transferase	211
643871669	445	46.46	24	443	13	436	6.0e-112	398	COG3493	Na+/citrate or Na+/malate symporter	438
643871670	477	50.37	78	477	12	417	0.0e+00	478	COG0281	Malic enzyme	432
643871671	536	43.93	1	533	1	535	0.0e+00	510	COG3290	Sensor histidine kinase regulating citrate/malate metabolism	537
643871672	240	50	2	227	1	221	1.0e-71	262	COG4565	Response regulator of citrate/malate metabolism	224
643871674	266	56.23	1	265	2	263	2.0e-95	342	COG0351	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	263
643871675	211	42.18	1	211	2	211	7.0e-47	180	COG0352	Thiamine monophosphate synthase	211
643871676	267	55.47	11	264	4	258	7.0e-73	267	COG2145	Hydroxyethylthiazole kinase, sugar kinase family	265
643871678	389	20.42	71	356	1	278	1.0e-22	101	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
643871680	378	33.04	43	375	8	350	2.0e-64	239	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
643871681	254	38.19	5	251	1	251	1.0e-48	186	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643871682	439	53.74	1	438	2	442	6.0e-96	344	COG2610	H+/gluconate symporter or related permease	442
643871683	332	29.79	6	332	1	329	3.0e-70	259	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643871684	175	59.75	13	171	1	158	9.0e-64	235	COG3265	Gluconate kinase	161
643871685	600	38.27	8	593	5	568	0.0e+00	546	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
643871686	215	56.46	3	211	2	210	2.0e-61	228	COG0800	2-keto-3-deoxy-6-phosphogluconate aldolase	211
643871687	190	38.34	4	190	2	167	2.0e-35	142	COG0629	Single-stranded DNA-binding protein	167
643871688	944	68.44	1	941	3	935	0.0e+00	1607	COG0178	Excinuclease UvrABC ATPase subunit	935
643871689	330	33.44	5	325	4	313	2.0e-67	249	COG1181	D-alanine-D-alanine ligase and related ATP-grasp enzymes	317
643871692	239	21.61	7	237	1	228	9.0e-26	110	COG1011	FMN phosphatase YigB, HAD superfamily	229
643871693	315	27.55	1	262	1	262	1.0e-33	137	COG0583	DNA-binding transcriptional regulator, LysR family	297
643871694	433	20	27	412	5	386	9.0e-16	78.3	COG2814	Predicted arabinose efflux permease, MFS family	394
643871695	146	58.22	1	146	1	145	5.0e-55	206	COG1490	D-Tyr-tRNAtyr deacylase	145
643871697	679	16.09	4	553	3	529	1.0e-06	48.5	COG2982	Uncharacterized protein involved in outer membrane biogenesis	648
643871698	689	54.85	4	679	8	674	0.0e+00	881	COG1200	RecG-like helicase	677
643871699	184	66.86	1	175	2	176	4.0e-70	257	COG3730	Phosphotransferase system sorbitol-specific component IIC	176
643871700	327	67.68	1	327	1	328	0.0e+00	467	COG3732	Phosphotransferase system sorbitol-specific component IIBC	328
643871701	121	50.83	1	120	1	120	3.0e-34	137	COG3731	Phosphotransferase system sorbitol-specific component IIA	123
643871702	258	34.23	1	256	4	251	1.0e-37	150	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643871704	254	42.8	6	254	6	252	6.0e-64	237	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643871705	151	37.7	23	143	2	123	2.0e-10	58.4	COG1846	DNA-binding transcriptional regulator, MarR family	126
643871706	265	53.46	7	265	9	268	3.0e-89	321	COG1464	ABC-type metal ion transport system, periplasmic component/surface antigen	268
643871707	217	63.13	1	217	6	222	2.0e-72	265	COG2011	ABC-type methionine transport system, permease component	222
643871708	347	57.73	1	342	1	339	4.0e-126	444	COG1135	ABC-type methionine transport system, ATPase component	339
643871710	347	69.19	5	346	1	342	0.0e+00	485	COG1077	Actin-like ATPase involved in cell morphogenesis	342
643871711	317	36.9	4	273	2	272	8.0e-62	230	COG1792	Cell shape-determining protein MreC	284
643871712	163	38.75	5	163	4	163	1.0e-21	96.4	COG2891	Cell shape-determining protein MreD	167
643871713	192	47.25	7	187	5	186	4.0e-56	210	COG0424	Predicted house-cleaning NTP pyrophosphatase, Maf/HAM1 superfamily	193
643871714	489	52.56	4	489	3	483	0.0e+00	536	COG1530	Ribonuclease G or E	487
643871715	1254	27.24	1	1245	17	1270	0.0e+00	548	COG3164	Uncharacterized conserved protein YhdP, contains DUF3971 and AsmA2 domains	1271
643871716	273	38.24	1	266	3	263	7.0e-51	194	COG0388	Predicted amidohydrolase	274
643871717	481	42.22	17	480	1	454	4.0e-125	442	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
643871718	174	49.4	8	173	19	183	1.0e-40	158	COG3028	Ribosomal 50S subunit-associated protein YjgA (function unknown), DUF615 family	187
643871719	447	35.96	15	447	2	454	4.0e-90	325	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
643871720	109	64.52	6	98	8	100	6.0e-25	105	COG2926	Uncharacterized conserved protein YeeX, DUF496 family	109
643871722	676	45.85	1	655	1	655	0.0e+00	604	COG0210	Superfamily I DNA or RNA helicase	655
643871724	372	25.4	1	302	1	281	1.0e-19	91.1	COG2358	TRAP-type uncharacterized transport system, periplasmic component	321
643871725	408	52.58	2	405	1	405	1.0e-129	456	COG0520	Selenocysteine lyase/Cysteine desulfurase	405
643871726	152	40	15	144	6	135	2.0e-27	115	COG2166	Sulfur transfer protein SufE, Fe-S center assembly	144
643871727	225	24.14	9	214	12	237	1.0e-11	63.4	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
643871728	259	60	5	259	9	258	1.0e-100	359	COG1179	tRNA A37 threonylcarbamoyladenosine dehydratase	263
643871730	113	43.52	1	107	4	108	1.0e-24	105	COG3952	Uncharacterized N-terminal domain of lipid-A-disaccharide synthase	113
643871731	571	29.83	14	472	6	463	5.0e-39	156	COG1807	4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of PMT family	535
643871732	335	32.94	1	333	1	312	3.0e-54	205	COG0451	Nucleoside-diphosphate-sugar epimerase	314
643871733	197	39.38	2	189	1	189	2.0e-28	118	COG3009	Uncharacterized lipoprotein YmbA	190
643871734	545	41.5	1	545	7	552	0.0e+00	527	COG3008	Paraquat-inducible protein B	553
643871735	433	41.75	4	426	6	418	3.0e-109	388	COG2995	Uncharacterized paraquat-inducible protein A	418
643871736	494	39.02	19	362	1	338	9.0e-119	420	COG0059	Ketol-acid reductoisomerase	338
643871737	292	34.35	1	292	1	289	2.0e-36	146	COG0583	DNA-binding transcriptional regulator, LysR family	297
643871738	549	53.66	49	538	4	446	0.0e+00	546	COG0166	Glucose-6-phosphate isomerase	446
643871739	557	40	359	542	1	181	2.0e-43	171	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643871740	639	72.77	1	468	1	469	0.0e+00	717	COG2213	Phosphotransferase system, mannitol-specific IIBC component	472
643871741	382	32.21	2	382	17	455	7.0e-80	291	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
643871742	178	38.32	11	177	9	172	5.0e-33	133	COG3722	DNA-binding transcriptional regulator, MltR family	174
643871743	581	61.74	243	581	1	340	1.0e-96	347	COG1299	Phosphotransferase system, fructose-specific IIC component	343
643871744	312	46.1	5	311	2	309	5.0e-92	331	COG1105	Fructose-1-phosphate kinase or kinase (PfkB)	310
643871745	377	50.71	4	143	3	142	1.0e-45	177	COG4668	Mannitol/fructose-specific phosphotransferase system, IIA domain	142
643871746	331	30.54	1	331	1	330	6.0e-55	208	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643871747	155	44.44	1	152	1	151	1.0e-42	165	COG0698	Ribose 5-phosphate isomerase RpiB	151
643871748	456	31.97	11	450	18	455	3.0e-64	239	COG0534	Na+-driven multidrug efflux pump	455
643871749	464	32.27	22	457	8	444	7.0e-44	171	COG1538	Outer membrane protein TolC	457
643871750	659	48.23	9	232	1	226	2.0e-77	283	COG1136	ABC-type lipoprotein export system, ATPase component	226
643871751	400	27.52	11	377	19	352	4.0e-26	112	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
643871753	361	44.69	4	360	2	351	2.0e-99	356	COG4148	ABC-type molybdate transport system, ATPase component	352
643871754	225	40.09	1	222	1	222	3.0e-55	208	COG4149	ABC-type molybdate transport system, permease component	225
643871755	283	35.56	16	150	7	130	7.0e-26	111	COG2005	DNA-binding transcriptional regulator ModE (molybdenum-dependent)	130
643871755	283	37.68	142	210	1	69	2.0e-12	66.5	COG3585	Molybdopterin-binding protein	69
643871756	254	53.7	173	226	5	58	4.0e-13	68.9	COG2771	DNA-binding transcriptional regulator, CsgD family	65
643871757	454	57.39	1	454	1	460	0.0e+00	642	COG1207	Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	460
643871758	257	45.45	5	254	2	253	9.0e-63	233	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643871759	611	53.92	1	611	1	597	0.0e+00	813	COG0449	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains	597
643871765	93	52.87	1	87	1	87	2.0e-27	114	COG1342	Predicted DNA-binding protein, UPF0251 family	99
643871766	41	58.54	1	41	1	38	6.0e-06	42.5	COG0257	Ribosomal protein L36	38
643871768	174	36.53	1	164	1	165	9.0e-20	90.1	COG1495	Disulfide bond formation protein DsbB	170
643871769	140	48.87	1	133	7	138	4.0e-35	140	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
643871770	181	26.67	1	98	1	103	1.0e-07	49.9	COG1433	Predicted Fe-Mo cluster-binding protein, NifX family	121
643871772	215	42.56	10	198	2	194	8.0e-63	233	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	194
643871773	325	29.39	14	317	3	315	6.0e-28	118	COG1275	Tellurite resistance protein TehA and related permeases	329
643871774	569	33.93	4	448	1	415	5.0e-59	222	COG0446	NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase	415
643871775	114	40.23	24	110	32	118	3.0e-13	67.3	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	124
643871776	141	28.21	27	138	24	139	2.0e-09	55.4	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
643871777	280	37.5	6	265	2	246	2.0e-47	182	COG1237	Metal-dependent hydrolase, beta-lactamase superfamily II	259
643871781	353	48.49	21	351	12	334	6.0e-70	257	COG2855	Uncharacterized membrane protein YadS	334
643871782	158	51.95	5	158	3	156	1.0e-44	172	COG0783	DNA-binding ferritin-like protein (oxidative damage protectant)	156
643871783	273	32.59	4	273	3	262	5.0e-50	191	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
643871784	269	44.4	1	263	3	270	2.0e-61	229	COG1968	Undecaprenyl pyrophosphate phosphatase UppP	270
643871792	336	59.52	5	335	1	329	0.0e+00	525	COG0113	Delta-aminolevulinic acid dehydratase, porphobilinogen synthase	330
643871793	543	44.06	1	516	2	517	0.0e+00	502	COG0661	Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family	517
643871794	206	34.5	5	203	2	201	3.0e-30	125	COG3165	Ubiquinone biosynthesis protein UbiJ, contains SCP2 domain	204
643871795	247	61.67	9	247	1	238	2.0e-89	322	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
643871797	219	44.13	2	208	16	227	1.0e-38	153	COG1738	Uncharacterized PurR-regulated membrane protein YhhQ, DUF165 family	233
643871798	910	60.63	310	910	2	593	0.0e+00	803	COG0749	DNA polymerase I - 3'-5' exonuclease and polymerase domains	593
643871799	212	52.76	6	203	2	200	6.0e-68	250	COG0218	GTP-binding protein EngB required for normal cell division	200
643871803	720	34.93	6	540	9	549	3.0e-124	439	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
643871804	172	41.28	1	172	1	160	7.0e-44	170	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
643871805	194	36.27	4	194	1	187	6.0e-39	154	COG3658	Cytochrome b	192
643871806	418	75.68	2	408	1	407	0.0e+00	541	COG3633	Na+/serine symporter	407
643871807	89	48.31	1	88	1	89	5.0e-20	89.1	COG1937	DNA-binding transcriptional regulator, FrmR family	89
643871808	330	30.77	23	328	20	290	3.0e-47	182	COG1230	Co/Zn/Cd efflux system component	296
643871809	661	24.38	12	328	6	294	2.0e-23	104	COG0501	Zn-dependent protease with chaperone function	302
643871810	198	40.51	2	196	1	185	6.0e-44	170	COG1704	Uncharacterized conserved protein	185
643871811	729	45.51	8	650	1	649	0.0e+00	596	COG0210	Superfamily I DNA or RNA helicase	655
643871812	622	57.23	1	622	7	627	0.0e+00	808	COG3158	K+ transporter	627
643871814	463	43.81	11	462	1	448	8.0e-74	271	COG1538	Outer membrane protein TolC	457
643871815	1048	55.09	1	1028	2	1008	0.0e+00	1081	COG0841	Multidrug efflux pump subunit AcrB	1009
643871816	396	37.5	9	380	8	368	8.0e-32	131	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
643871817	202	19.19	5	202	1	196	8.0e-13	67.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
643871820	159	28.85	1	156	24	179	6.0e-22	97	COG3149	Type II secretory pathway, component PulM	181
643871821	395	31.55	5	394	7	390	1.0e-61	230	COG3297	Type II secretory pathway, component PulL	390
643871822	327	38.15	4	327	5	321	4.0e-63	235	COG3156	Type II secretory pathway, component PulK	323
643871823	215	34.36	10	204	5	191	5.0e-28	117	COG4795	Type II secretory pathway, component PulJ	194
643871826	146	37.84	1	137	2	149	5.0e-20	90.5	COG2165	Type II secretory pathway, pseudopilin PulG	149
643871827	406	45.19	1	405	1	397	3.0e-102	365	COG1459	Type II secretory pathway, component PulF	397
643871828	500	53.55	10	499	12	500	0.0e+00	564	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
643871829	685	32.79	20	634	28	563	2.0e-97	350	COG1450	Type II secretory pathway component GspD/PulD (secretin)	587
643871831	282	25.37	14	279	14	275	3.0e-36	145	COG3031	Type II secretory pathway, component PulC	275
643871832	196	23.65	52	184	11	156	8.0e-06	43.8	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
643871835	300	23.99	4	272	1	268	6.0e-20	91.6	COG0583	DNA-binding transcriptional regulator, LysR family	297
643871836	207	48.73	6	201	4	200	2.0e-43	169	COG1279	Arginine exporter protein ArgO	202
643871837	143	33.1	1	143	8	146	2.0e-20	91.6	COG0071	Molecular chaperone IbpA, HSP20 family	146
643871838	367	30.47	11	360	85	432	2.0e-79	289	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
643871839	617	37.84	7	616	4	607	0.0e+00	463	COG4206	Outer membrane cobalamin receptor protein	608
643871840	635	57.08	1	635	22	652	0.0e+00	844	COG1166	Arginine decarboxylase (spermidine biosynthesis)	652
643871841	457	30.84	17	454	7	454	7.0e-55	208	COG0471	Di- and tricarboxylate transporter	461
643871842	158	35.33	1	155	2	168	6.0e-34	136	COG0602	Organic radical activating enzyme	212
643871843	244	46.18	1	244	1	248	8.0e-75	273	COG3338	Carbonic anhydrase	250
643871844	317	48.04	11	312	4	308	7.0e-86	310	COG1560	Lauroyl/myristoyl acyltransferase	308
643871845	481	58.02	3	475	1	463	0.0e+00	611	COG2870	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase	467
643871846	424	33.71	1	424	1	438	3.0e-77	282	COG4097	Predicted ferric reductase	438
643871847	316	28.43	1	307	4	316	5.0e-28	118	COG1275	Tellurite resistance protein TehA and related permeases	329
643871848	437	25.98	29	430	51	454	1.0e-43	171	COG1538	Outer membrane protein TolC	457
643871849	378	33.64	160	375	65	281	2.0e-22	100	COG0842	ABC-type multidrug transport system, permease component	286
643871850	308	38.67	7	301	4	292	1.0e-73	270	COG1131	ABC-type multidrug transport system, ATPase component	293
643871852	220	22.01	11	219	5	201	4.0e-07	48.5	COG1309	DNA-binding transcriptional regulator, AcrR family	201
643871854	147	49.31	4	146	3	145	1.0e-34	138	COG3151	Uncharacterized protein YqiB, DUF1249 family	147
643871855	273	32.01	14	273	1	270	3.0e-33	135	COG1409	3',5'-cyclic AMP phosphodiesterase CpdA	301
643871856	191	42.02	4	191	1	188	4.0e-53	200	COG3150	Predicted esterase YcpF, UPF0227 family	191
643871857	630	46.87	1	629	2	632	0.0e+00	837	COG0187	DNA gyrase/topoisomerase IV, subunit B	635
643871859	559	41.58	8	548	11	552	2.0e-121	430	COG0659	Sulfate permease or related transporter, MFS superfamily	554
643871860	74	36.67	14	73	4	63	3.0e-06	43.4	COG5457	Uncharacterized conserved protein YjiS, DUF1127 family	63
643871861	86	39.53	1	86	1	84	6.0e-13	65.7	COG3630	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit	84
643871862	601	64.5	6	479	4	472	0.0e+00	728	COG5016	Pyruvate/oxaloacetate carboxyltransferase	472
643871863	433	66.51	1	430	1	374	0.0e+00	477	COG1883	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit	375
643871864	172	29.13	34	160	3	126	1.0e-10	59.2	COG1846	DNA-binding transcriptional regulator, MarR family	126
643871866	93	49.46	5	92	3	95	8.0e-25	105	COG5453	Uncharacterized protein	96
643871867	450	21.35	28	450	3	387	4.0e-30	126	COG0247	Fe-S oxidoreductase	388
643871868	310	38.64	4	310	2	307	2.0e-75	276	COG1105	Fructose-1-phosphate kinase or kinase (PfkB)	310
643871869	111	44.95	1	109	2	88	1.0e-17	82	COG3809	Predicted nucleic acid-binding protein, contains Zn-finger domain	88
643871870	453	19.39	28	317	12	340	4.0e-16	79.7	COG3614	Extracellular (periplasmic) sensor domain CHASE1 (specificity unknown)	348
643871872	446	20.65	19	438	27	437	7.0e-29	121	COG2271	Sugar phosphate permease	448
643871873	309	28.43	5	295	4	293	3.0e-41	162	COG0583	DNA-binding transcriptional regulator, LysR family	297
643871874	299	38.54	1	299	1	297	1.0e-78	286	COG1951	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain	297
643871875	202	49.73	1	180	1	177	7.0e-55	206	COG1838	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain	184
643871876	292	37.5	17	281	6	266	6.0e-64	237	COG0179	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	266
643871877	540	63.38	6	539	5	529	0.0e+00	797	COG1866	Phosphoenolpyruvate carboxykinase, ATP-dependent	529
643871879	707	45.17	3	706	1	698	0.0e+00	871	COG1328	Anaerobic ribonucleoside-triphosphate reductase	700
643871880	535	63.53	7	534	9	529	0.0e+00	807	COG1866	Phosphoenolpyruvate carboxykinase, ATP-dependent	529
643871881	299	48.24	6	283	5	286	4.0e-87	314	COG1281	Redox-regulated molecular chaperone, HSP33 family	286
643871882	132	58.59	3	101	2	100	5.0e-27	113	COG1188	Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain	100
643871883	210	34.65	11	196	1	200	1.0e-28	119	COG0625	Glutathione S-transferase	211
643871884	146	50	1	146	1	155	7.0e-47	179	COG2969	Stringent starvation protein B	155
643871885	192	38.89	13	191	17	196	6.0e-36	143	COG2823	Osmotically-inducible protein OsmY, contains BON domain	196
643871886	192	49.72	2	178	3	176	6.0e-44	170	COG0279	Phosphoheptose isomerase	176
643871887	124	41.59	13	124	1	112	3.0e-29	120	COG0792	Predicted endonuclease distantly related to archaeal Holliday junction resolvase	114
643871888	625	32.69	2	608	7	600	2.0e-77	283	COG3107	Outer membrane lipoprotein LpoA, binds and activates PBP1a	604
643871889	281	56.36	4	277	4	275	4.0e-100	357	COG0313	16S rRNA C1402 (ribose-2'-O) methylase RsmI	275
643871890	458	30.69	8	458	17	534	6.0e-81	295	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
643871891	308	35.19	4	306	5	321	1.0e-45	177	COG1441	O-succinylbenzoate synthase	321
643871892	286	76.26	11	286	5	282	0.0e+00	514	COG0447	1,4-Dihydroxy-2-naphthoyl-CoA synthase	282
643871893	248	23.28	3	245	21	281	1.0e-15	76.7	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
643871894	573	42.76	11	572	6	565	0.0e+00	510	COG1165	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	566
643871895	439	35.11	4	436	1	418	1.0e-78	287	COG1169	Isochorismate synthase EntC	423
643871896	306	38.08	5	305	3	299	1.0e-54	207	COG1575	1,4-dihydroxy-2-naphthoate octaprenyltransferase	303
643871897	206	34.48	1	201	1	203	5.0e-30	124	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
643871898	190	36.16	4	179	5	166	1.0e-14	73.2	COG3078	Ribosome assembly protein YihI, activator of Der GTPase	169
643871900	347	28.74	2	336	1	333	9.0e-57	214	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643871901	258	38.52	6	248	3	246	1.0e-54	206	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643871902	457	41.74	14	447	1	416	2.0e-121	429	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
643871903	458	51.76	171	454	1	262	2.0e-86	313	COG1760	L-serine deaminase	262
643871904	345	52.24	7	336	1	335	1.0e-76	280	COG1299	Phosphotransferase system, fructose-specific IIC component	343
643871905	99	55.21	1	96	2	97	5.0e-30	122	COG1445	Phosphotransferase system fructose-specific component IIB	122
643871906	833	40.28	118	676	3	567	0.0e+00	536	COG1080	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)	574
643871907	284	28.81	164	281	2	119	2.0e-21	96.1	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643871908	175	48.7	1	153	1	153	6.0e-25	107	COG3133	Outer membrane lipoprotein SlyB	154
643871909	300	37.99	1	298	6	305	7.0e-57	214	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
643871910	105	52.53	1	99	2	100	1.0e-24	104	COG1447	Phosphotransferase system cellobiose-specific component IIA	105
643871911	460	48.26	4	459	2	454	0.0e+00	571	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
643871912	439	40.23	5	433	2	432	5.0e-109	388	COG1455	Phosphotransferase system cellobiose-specific component IIC	432
643871913	101	53.47	1	101	1	101	5.0e-27	112	COG1440	Phosphotransferase system cellobiose-specific component IIB	102
643871914	435	39.49	6	424	1	421	2.0e-96	346	COG1455	Phosphotransferase system cellobiose-specific component IIC	432
643871915	328	30.33	2	325	1	330	2.0e-51	196	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643871917	474	50.84	1	474	3	457	0.0e+00	551	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
643871918	350	53.85	6	350	7	356	1.0e-113	403	COG3852	Signal transduction histidine kinase, nitrogen specific	363
643871920	469	49.58	1	469	1	443	0.0e+00	525	COG0174	Glutamine synthetase	443
643871921	608	69.27	1	602	1	601	0.0e+00	1016	COG1217	Predicted membrane GTPase involved in stress response	603
643871922	302	32.73	33	296	23	296	5.0e-34	138	COG1295	Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase)	303
643871923	106	50.52	9	104	11	107	3.0e-21	93.8	COG3099	Uncharacterized conserved protein YciU, UPF0263 family	108
643871924	759	44.07	9	745	6	742	0.0e+00	769	COG0188	DNA gyrase/topoisomerase IV, subunit A	804
643871925	240	28.1	2	240	1	238	1.0e-26	113	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
643871926	221	33.5	14	215	1	198	5.0e-33	134	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
643871928	306	25	4	302	3	306	8.0e-29	121	COG0679	Predicted permease	311
643871930	443	70.72	1	443	1	444	0.0e+00	705	COG1220	ATP-dependent protease HslVU (ClpYQ), ATPase subunit	444
643871931	180	72	1	175	4	178	2.0e-73	268	COG5405	ATP-dependent protease HslVU (ClpYQ), peptidase subunit	178
643871933	580	40.51	5	580	3	577	0.0e+00	588	COG0018	Arginyl-tRNA synthetase	577
643871934	194	26.56	1	181	10	201	5.0e-22	97.7	COG2802	Uncharacterized protein, similar to the N-terminal domain of Lon protease	221
643871935	192	33.33	8	190	1	180	7.0e-25	107	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
643871936	218	29.82	2	216	1	216	5.0e-31	127	COG3806	Anti-sigma factor ChrR, cupin superfamily	216
643871937	316	24.75	6	300	1	291	6.0e-29	121	COG0583	DNA-binding transcriptional regulator, LysR family	297
643871938	294	34.03	4	289	3	274	4.0e-56	211	COG0388	Predicted amidohydrolase	274
643871939	364	50.69	6	364	6	346	1.0e-126	446	COG2957	Agmatine/peptidylarginine deiminase	346
643871941	734	46.65	9	732	5	730	0.0e+00	779	COG1198	Primosomal protein N' (replication factor Y) - superfamily II helicase	730
643871942	70	56.16	1	69	1	73	7.0e-21	92.2	COG0254	Ribosomal protein L31	75
643871943	414	53.38	1	410	13	411	0.0e+00	502	COG0281	Malic enzyme	432
643871944	376	27.2	1	360	3	332	3.0e-26	112	COG3203	Outer membrane protein (porin)	354
643871945	335	63.36	1	332	1	332	0.0e+00	462	COG1494	Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase or related protein	332
643871947	488	43.76	22	481	1	451	0.0e+00	482	COG0493	NADPH-dependent glutamate synthase beta chain or related oxidoreductase	457
643871948	1544	57.09	713	1223	3	485	0.0e+00	660	COG0069	Glutamate synthase domain 2	485
643871949	302	26.6	6	297	1	297	1.0e-34	140	COG0583	DNA-binding transcriptional regulator, LysR family	297
643871950	366	65.06	1	351	1	352	0.0e+00	510	COG2933	23S rRNA C2498 (ribose-2'-O)-methylase RlmM	358
643871951	260	31.66	1	253	10	267	2.0e-38	153	COG0258	5'-3' exonuclease	310
643871952	450	32.2	132	334	4	201	5.0e-40	159	COG1611	Predicted Rossmann fold nucleotide-binding protein	205
643871954	283	65.93	5	138	1	135	6.0e-50	191	COG2904	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF, N-terminal domain	137
643871958	111	39.42	1	104	3	106	3.0e-19	87.3	COG3098	Uncharacterized conserved protein YqcC, DUF446 family	109
643871959	242	36.68	1	227	76	289	3.0e-48	185	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
643871961	270	38.17	1	256	4	263	1.0e-55	210	COG2116	Formate/nitrite transporter FocA, FNT family	265
643871962	109	33.94	1	108	3	106	4.0e-18	83.1	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	106
643871963	849	51.05	1	810	1	793	0.0e+00	1019	COG1251	NAD(P)H-nitrite reductase, large subunit	793
643871964	347	31.29	8	285	1	266	3.0e-57	215	COG1018	Ferredoxin-NADP reductase	266
643871965	553	43.11	1	551	4	560	0.0e+00	568	COG1151	Hydroxylamine reductase (hybrid-cluster protein)	576
643871966	410	35.55	21	410	30	420	3.0e-61	229	COG4942	Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB	420
643871967	512	59.45	3	508	1	506	0.0e+00	705	COG0696	Phosphoglycerate mutase (BPG-independent, AlkP superfamily)	509
643871968	143	31.82	35	143	2	110	9.0e-18	82.7	COG0607	Rhodanese-related sulfurtransferase	110
643871969	157	60.93	1	151	2	150	2.0e-52	198	COG1952	Preprotein translocase subunit SecB	157
643871970	334	51.68	8	334	5	329	7.0e-119	420	COG0240	Glycerol-3-phosphate dehydrogenase	329
643871971	192	50	98	190	1	93	4.0e-25	107	COG0694	Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain	93
643871972	236	37.04	18	231	11	223	5.0e-45	174	COG1040	Predicted amidophosphoribosyltransferases	225
643871973	493	51.84	60	492	2	403	6.0e-114	404	COG0004	Ammonia channel protein AmtB	409
643871974	261	29.48	4	255	14	281	5.0e-25	108	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
643871975	767	59.38	1	767	7	779	0.0e+00	983	COG2183	Transcriptional accessory protein Tex/SPT6	780
643871976	161	46.71	6	156	1	151	1.0e-39	155	COG0782	Transcription elongation factor, GreA/GreB family	151
643871977	152	46.05	1	152	1	146	9.0e-43	166	COG2001	MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity	146
643871978	308	56.77	3	307	7	313	8.0e-116	410	COG0275	16S rRNA C1402 N4-methylase RsmH	314
643871979	103	40.82	4	100	6	103	1.0e-13	68	COG3116	Cell division protein FtsL, interacts with FtsB, FtsL and FtsQ	105
643871980	586	39.74	5	564	1	599	3.0e-129	456	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
643871981	489	41.92	6	488	1	475	0.0e+00	470	COG0769	UDP-N-acetylmuramyl tripeptide synthase	475
643871982	459	46.27	2	453	1	450	7.0e-127	447	COG0770	UDP-N-acetylmuramyl pentapeptide synthase	451
643871983	360	47.26	20	360	1	316	2.0e-55	210	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
643871984	430	47.3	1	430	7	446	3.0e-128	452	COG0771	UDP-N-acetylmuramoylalanine-D-glutamate ligase	448
643871985	384	45.26	14	376	12	377	4.0e-81	295	COG0772	Bacterial cell division protein FtsW, lipid II flippase	381
643871986	355	46.5	3	355	1	355	2.0e-99	355	COG0707	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	357
643871987	484	53.56	13	472	1	455	0.0e+00	580	COG0773	UDP-N-acetylmuramate-alanine ligase	459
643871988	257	28.81	15	250	29	269	2.0e-34	139	COG1589	Cell division septal protein FtsQ	269
643871989	418	50	8	418	6	418	0.0e+00	469	COG0849	Cell division ATPase FtsA	418
643871990	386	57.67	14	339	12	336	4.0e-102	365	COG0206	Cell division GTPase FtsZ	338
643871991	307	65.76	1	295	1	294	4.0e-127	448	COG0774	UDP-3-O-acyl-N-acetylglucosamine deacetylase	300
643871993	907	59.18	2	900	1	822	0.0e+00	1099	COG0653	Preprotein translocase subunit SecA (ATPase, RNA helicase)	822
643871994	132	32	6	119	11	128	4.0e-12	63.9	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
643871995	72	58.49	3	55	6	58	5.0e-14	69.3	COG3024	Endogenous inhibitor of DNA gyrase, YacG/DUF329 family	65
643871996	205	43.28	1	201	2	200	2.0e-56	212	COG0237	Dephospho-CoA kinase	201
643871997	286	45.36	8	286	1	254	2.0e-36	146	COG1989	Prepilin signal peptidase PulO (type II secretory pathway) or related peptidase	254
643871998	418	40.7	21	418	3	397	9.0e-106	377	COG1459	Type II secretory pathway, component PulF	397
643871999	568	49.6	62	566	2	498	0.0e+00	561	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
643872000	147	33.05	1	118	1	118	1.0e-13	68.8	COG4969	Tfp pilus assembly protein, major pilin PilA	125
643872001	428	62.47	1	427	1	427	0.0e+00	626	COG0151	Phosphoribosylamine-glycine ligase	428
643872002	530	66.73	6	530	1	515	0.0e+00	808	COG0138	AICAR transformylase/IMP cyclohydrolase PurH	515
643872004	83	26.74	4	83	1	86	3.0e-06	43.5	COG2161	Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family	86
643872005	93	34.44	1	89	1	90	4.0e-14	69.5	COG2026	mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system	90
643872006	157	48.37	1	153	4	154	2.0e-34	138	COG1522	DNA-binding transcriptional regulator, Lrp family	154
643872008	555	48.61	3	535	1	528	0.0e+00	578	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
643872011	356	31.58	2	355	1	361	8.0e-50	191	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
643872012	367	33.71	1	342	2	353	5.0e-49	188	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
643872013	500	51.6	1	495	1	485	0.0e+00	582	COG0260	Leucyl aminopeptidase	485
643872014	159	33.55	7	157	1	143	1.0e-27	115	COG2927	DNA polymerase III, chi subunit	144
643872015	950	55.21	1	948	1	876	0.0e+00	1235	COG0525	Valyl-tRNA synthetase	877
643872016	297	33.22	3	292	2	291	5.0e-40	158	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872017	180	41.01	1	177	4	181	8.0e-41	160	COG3038	Cytochrome b561	181
643872018	186	32.43	2	177	3	186	5.0e-26	110	COG2353	Polyisoprenoid-binding periplasmic protein YceI	192
643872019	192	42.93	4	192	1	191	4.0e-38	151	COG2353	Polyisoprenoid-binding periplasmic protein YceI	192
643872020	240	40.16	1	233	1	244	7.0e-52	197	COG1741	Redox-sensitive bicupin YhaK, pirin superfamily	276
643872021	487	28.09	9	485	4	414	7.0e-74	271	COG2195	Di- or tripeptidase	414
643872022	358	49.04	1	358	1	359	7.0e-117	413	COG0787	Alanine racemase	360
643872023	330	38.58	1	328	4	333	2.0e-68	252	COG3367	Uncharacterized conserved protein, NAD-dependent epimerase/dehydratase family	339
643872024	327	28.01	1	327	2	355	6.0e-46	177	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
643872025	286	34.95	3	285	2	284	3.0e-59	221	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
643872026	462	51.34	1	445	1	445	0.0e+00	485	COG1115	Na+/alanine symporter	452
643872027	187	52.13	1	184	2	188	8.0e-67	246	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	194
643872028	521	72.99	1	519	1	520	0.0e+00	841	COG3634	Alkyl hydroperoxide reductase subunit AhpF	520
643872029	69	60.61	3	68	1	66	2.0e-22	97.5	COG1278	Cold shock protein, CspA family	67
643872030	218	27.57	11	218	15	219	6.0e-23	100	COG1418	HD superfamily phosphodieaserase, includes HD domain of RNase Y	222
643872031	139	55.4	1	139	1	135	1.0e-44	171	COG1869	D-ribose pyranose/furanose isomerase RbsD	135
643872032	308	43.31	4	306	1	310	3.0e-60	225	COG0524	Sugar or nucleoside kinase, ribokinase family	311
643872033	139	58.27	1	139	1	135	2.0e-47	181	COG1869	D-ribose pyranose/furanose isomerase RbsD	135
643872034	500	54.95	1	492	5	499	0.0e+00	666	COG1129	ABC-type sugar transport system, ATPase component	500
643872035	328	53.8	16	328	1	311	2.0e-71	262	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
643872036	295	42	3	295	10	309	6.0e-49	188	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
643872037	307	43.81	4	307	1	311	4.0e-57	215	COG0524	Sugar or nucleoside kinase, ribokinase family	311
643872038	334	50.3	2	334	1	333	1.0e-101	363	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643872039	314	29.56	1	295	1	313	4.0e-45	175	COG1397	ADP-ribosylglycohydrolase	314
643872041	431	63.64	4	431	3	430	0.0e+00	641	COG0001	Glutamate-1-semialdehyde aminotransferase	432
643872042	115	58.72	7	115	2	110	3.0e-38	150	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
643872044	367	50.41	1	366	4	370	3.0e-113	401	COG2377	1,6-Anhydro-N-acetylmuramate kinase	371
643872045	399	42.36	8	398	7	400	4.0e-108	384	COG0162	Tyrosyl-tRNA synthetase	401
643872046	229	29.37	1	137	6	141	5.0e-13	68.1	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
643872047	176	25.25	1	171	2	195	1.0e-27	116	COG1057	Nicotinic acid mononucleotide adenylyltransferase	197
643872048	410	33.75	7	394	11	376	1.0e-75	277	COG1488	Nicotinic acid phosphoribosyltransferase	405
643872049	678	28.28	321	605	10	242	3.0e-28	120	COG0171	NH3-dependent NAD+ synthetase	268
643872050	65	37.31	1	64	3	69	3.0e-10	56.9	COG2608	Copper chaperone CopZ	71
643872051	797	35	13	71	8	67	1.0e-07	52.7	COG2608	Copper chaperone CopZ	71
643872051	797	47.64	74	787	2	710	0.0e+00	714	COG2217	Cation transport ATPase	713
643872052	145	39.17	6	124	1	120	2.0e-24	105	COG0789	DNA-binding transcriptional regulator, MerR family	124
643872053	222	21.11	10	189	9	183	8.0e-08	50.8	COG1309	DNA-binding transcriptional regulator, AcrR family	201
643872054	377	25.78	86	371	14	282	4.0e-15	76.1	COG0842	ABC-type multidrug transport system, permease component	286
643872055	908	48.21	270	491	4	227	3.0e-70	260	COG1131	ABC-type multidrug transport system, ATPase component	293
643872056	325	24.54	5	254	11	277	6.0e-19	88.5	COG1566	Multidrug resistance efflux pump	352
643872059	1016	24.03	567	1016	1	385	1.0e-48	189	COG0247	Fe-S oxidoreductase	388
643872059	1016	31.79	29	542	9	459	6.0e-73	269	COG0277	FAD/FMN-containing dehydrogenase	459
643872060	145	31.21	1	140	1	141	8.0e-28	116	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
643872061	642	41.2	2	475	23	505	1.0e-122	433	COG0513	Superfamily II DNA and RNA helicase	513
643872062	403	33.14	86	402	16	353	8.0e-61	228	COG0144	16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family	355
643872063	211	52.13	2	211	4	214	7.0e-83	299	COG0259	Pyridoxine/pyridoxamine 5'-phosphate oxidase	214
643872064	1138	40.47	212	1113	3	834	0.0e+00	633	COG3264	Small-conductance mechanosensitive channel	835
643872065	470	54.74	1	470	4	477	0.0e+00	581	COG0469	Pyruvate kinase	477
643872066	476	18.73	42	401	6	319	2.0e-27	117	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
643872069	208	43.27	3	208	2	208	5.0e-27	114	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
643872070	437	44.84	4	426	1	425	4.0e-101	361	COG1114	Branched-chain amino acid permeases	431
643872072	365	16.86	1	286	2	348	1.0e-16	81.3	COG1819	UDP:flavonoid glycosyltransferase YjiC, YdhE family	406
643872073	572	53.55	3	564	1	549	0.0e+00	678	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
643872074	164	53.09	1	162	3	163	6.0e-48	183	COG0440	Acetolactate synthase, small subunit	163
643872077	212	49.03	6	211	2	207	2.0e-49	189	COG2860	Uncharacterized membrane protein YeiH	209
643872078	280	30.51	13	266	41	312	2.0e-34	139	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
643872079	230	50	1	230	3	233	4.0e-62	231	COG0775	Nucleoside phosphorylase	234
643872080	308	51.6	1	307	2	312	3.0e-117	415	COG1242	Radical SAM superfamily enzyme	312
643872082	455	26.51	12	453	22	410	1.0e-55	210	COG0232	dGTP triphosphohydrolase	412
643872083	167	21.26	1	163	2	175	1.0e-18	85.8	COG0250	Transcription antitermination factor NusG	178
643872084	243	39.15	4	236	1	228	1.0e-50	193	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
643872085	819	43.82	1	460	3	445	3.0e-125	442	COG0527	Aspartokinase	447
643872086	318	38.61	1	316	2	299	6.0e-81	294	COG0083	Homoserine kinase	299
643872087	424	32.42	1	424	1	410	5.0e-92	331	COG0498	Threonine synthase	411
643872088	171	52.56	18	171	1	156	3.0e-50	190	COG2190	Phosphotransferase system IIA component	156
643872089	572	59.02	1	571	2	572	0.0e+00	808	COG1080	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)	574
643872090	103	46.43	19	102	1	84	2.0e-23	100	COG1925	Phosphotransferase system, HPr and related phosphotransfer proteins	88
643872091	322	59.22	4	308	1	300	4.0e-111	394	COG0031	Cysteine synthase	300
643872092	514	36.96	53	506	104	553	4.0e-93	335	COG2989	Murein L,D-transpeptidase YcbB/YkuD	561
643872093	244	46.5	3	244	2	244	1.0e-52	199	COG2981	Uncharacterized protein involved in cysteine biosynthesis	250
643872094	260	30.34	1	260	1	322	5.0e-44	171	COG3115	Cell division protein ZipA, interacts with FtsZ	324
643872095	686	55.34	1	674	4	666	0.0e+00	908	COG0272	NAD-dependent DNA ligase	667
643872096	1296	38.86	158	965	1	730	0.0e+00	779	COG0046	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain	743
643872099	487	36.28	50	487	1	438	2.0e-76	280	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
643872102	278	49.12	1	278	5	287	9.0e-104	369	COG0788	Formyltetrahydrofolate hydrolase	287
643872104	157	21.99	8	148	15	152	5.0e-11	60.7	COG5608	LEA14-like dessication related protein	161
643872106	307	35.27	41	307	51	324	6.0e-62	231	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
643872108	443	27.05	25	415	13	402	2.0e-29	123	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
643872109	357	19.66	31	310	12	298	3.0e-14	72.7	COG1566	Multidrug resistance efflux pump	352
643872111	166	63.92	1	158	1	158	1.0e-61	228	COG2077	Peroxiredoxin	158
643872112	688	20.8	191	681	1	480	1.0e-39	158	COG0366	Glycosidase	505
643872114	295	71.22	3	280	1	278	2.0e-121	429	COG1348	Nitrogenase subunit NifH, an ATPase	278
643872115	482	37.47	22	480	1	449	7.0e-100	357	COG2710	Nitrogenase molybdenum-iron protein, alpha and beta chains	456
643872116	522	29.88	33	516	1	451	4.0e-82	298	COG2710	Nitrogenase molybdenum-iron protein, alpha and beta chains	456
643872117	70	36.36	4	67	3	65	3.0e-06	43.5	COG5554	Nitrogen fixation protein	69
643872119	457	32.82	14	456	14	449	1.0e-85	310	COG2710	Nitrogenase molybdenum-iron protein, alpha and beta chains	456
643872120	460	25.93	11	428	27	433	3.0e-49	189	COG2710	Nitrogenase molybdenum-iron protein, alpha and beta chains	456
643872123	412	35.02	4	409	1	408	2.0e-109	389	COG2081	Predicted flavoprotein YhiN	408
643872124	116	25.74	1	100	4	104	2.0e-09	54.4	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
643872125	297	45.32	4	123	7	143	1.0e-28	120	COG0822	NifU homolog involved in Fe-S cluster formation	150
643872126	401	54.69	4	383	3	385	0.0e+00	497	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
643872131	460	41.36	7	460	3	436	0.0e+00	464	COG1875	Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains	436
643872132	231	49.54	16	230	16	231	5.0e-62	230	COG3840	ABC-type thiamine transport system, ATPase component	231
643872133	535	32.28	3	529	9	539	4.0e-66	246	COG1178	ABC-type Fe3+ transport system, permease component	540
643872134	333	56.4	9	332	8	335	1.0e-112	399	COG4143	ABC-type thiamine transport system, periplasmic component	336
643872137	569	45.98	10	567	25	593	0.0e+00	568	COG4178	ABC-type uncharacterized transport system, permease and ATPase components	604
643872138	257	59.36	1	251	1	251	5.0e-106	377	COG4604	ABC-type enterochelin transport system, ATPase component	252
643872139	316	44.41	4	316	5	316	3.0e-70	258	COG4605	ABC-type enterochelin transport system, permease component	316
643872140	319	50.97	10	319	11	320	4.0e-88	318	COG4606	ABC-type enterochelin transport system, permease component	321
643872141	310	41.58	21	310	33	320	9.0e-79	287	COG4607	ABC-type enterochelin transport system, periplasmic component	320
643872142	641	18.34	12	641	39	768	2.0e-25	111	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
643872143	199	57.5	1	199	1	190	1.0e-73	269	COG0066	3-isopropylmalate dehydratase small subunit	191
643872144	465	57.57	1	465	1	422	0.0e+00	623	COG0065	Homoaconitase/3-isopropylmalate dehydratase large subunit	423
643872145	364	54.35	1	364	1	348	0.0e+00	460	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
643872146	521	50.84	3	414	1	409	6.0e-125	441	COG0119	Isopropylmalate/homocitrate/citramalate synthases	409
643872147	519	41.51	4	519	8	488	0.0e+00	524	COG0397	Uncharacterized conserved protein YdiU, UPF0061 family	488
643872148	340	18.52	47	311	1	241	6.0e-15	75.6	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
643872151	160	45.39	1	151	1	152	4.0e-43	167	COG4807	Uncharacterized conserved protein YehS, DUF1456 family	155
643872152	112	67.27	4	112	3	112	4.0e-43	166	COG2824	Uncharacterized Zn-ribbon-containing protein	112
643872153	75	41.18	1	68	2	69	2.0e-14	70.2	COG2501	Ribosome-associated protein YbcJ, S4-like RNA binding protein	73
643872154	163	59.41	8	108	11	111	5.0e-30	124	COG4628	Uncharacterized conserved protein, DUF2132 family	136
643872155	91	35.71	1	84	6	89	8.0e-15	72.2	COG3326	Uncharacterized membrane protein YsdA, DUF1294 family	94
643872156	131	41.22	1	131	3	131	1.0e-27	115	COG3791	Uncharacterized conserved protein	133
643872160	157	45.99	12	148	7	143	8.0e-40	156	COG5579	Uncharacterized protein, DUF1810 family	143
643872164	89	35.96	1	89	6	93	1.0e-10	58.4	COG4453	Uncharacterized conserved protein, DUF1778 family	95
643872167	239	30.7	11	238	18	226	1.0e-16	80	COG2801	Transposase InsO and inactivated derivatives	232
643872168	114	30.56	8	114	3	104	5.0e-07	46.4	COG2963	Transposase and inactivated derivatives	116
643872175	256	25.14	80	256	46	214	9.0e-20	90.9	COG2932	Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains	214
643872185	91	47.78	1	90	2	91	1.0e-17	81.3	COG0776	Bacterial nucleoid DNA-binding protein	94
643872191	196	22.22	9	185	2	164	1.0e-14	73.5	COG4382	Mu-like prophage protein gp16	170
643872192	140	37.96	3	139	4	137	1.0e-29	122	COG5566	Transcriptional regulator, Middle operon regulator (Mor) family	137
643872201	510	49.9	11	510	10	509	0.0e+00	615	COG4373	Mu-like prophage FluMu protein gp28	509
643872202	521	50	3	515	5	513	0.0e+00	586	COG4383	Mu-like prophage protein gp29	517
643872206	382	41.85	29	382	12	356	2.0e-75	276	COG4388	Mu-like prophage I protein	357
643872207	302	62.01	1	302	1	308	2.0e-119	421	COG4397	Mu-like prophage major head subunit gpT	308
643872209	139	52.52	1	139	1	139	7.0e-37	146	COG4387	Mu-like prophage protein gp36	139
643872223	449	37.27	4	435	3	425	3.0e-113	402	COG0044	Dihydroorotase or related cyclic amidohydrolase	430
643872225	118	39.29	3	112	1	109	1.0e-25	108	COG0537	Diadenosine tetraphosphate (Ap4A) hydrolase or other HIT family hydrolase	138
643872226	197	22.49	8	197	3	199	4.0e-07	48.1	COG3417	Outer membrane lipoprotein LpoB, binds and activates PBP1b	200
643872228	110	42.42	1	97	1	99	7.0e-17	79.1	COG1544	Ribosome-associated translation inhibitor RaiA	110
643872229	637	28.2	339	630	2	296	2.0e-26	114	COG0741	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)	296
643872230	270	21.52	10	263	8	308	2.0e-20	92.7	COG0451	Nucleoside-diphosphate-sugar epimerase	314
643872231	281	32.74	62	274	90	306	1.0e-22	100	COG3021	Uncharacterized conserved protein YafD, endonuclease/exonuclease/phosphatase (EEP) superfamily	309
643872233	160	38.99	1	158	1	159	4.0e-24	104	COG1286	Uncharacterized membrane protein, required for colicin V production	182
643872234	507	51.53	1	485	4	470	0.0e+00	594	COG0034	Glutamine phosphoribosylpyrophosphate amidotransferase	470
643872236	259	44.15	1	259	3	265	1.0e-31	130	COG0428	Zinc transporter ZupT	266
643872237	158	50.33	6	158	4	156	5.0e-46	176	COG0783	DNA-binding ferritin-like protein (oxidative damage protectant)	156
643872239	333	36.17	8	333	1	329	1.0e-70	260	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643872240	215	55.71	3	212	2	211	1.0e-62	232	COG0800	2-keto-3-deoxy-6-phosphogluconate aldolase	211
643872241	602	37.29	8	599	5	574	0.0e+00	553	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
643872242	174	61.64	9	167	1	158	9.0e-66	242	COG3265	Gluconate kinase	161
643872243	438	54.11	1	435	2	439	6.0e-95	341	COG2610	H+/gluconate symporter or related permease	442
643872245	517	53.31	1	238	7	248	4.0e-70	259	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
643872249	341	39.75	94	248	3	161	9.0e-32	131	COG4067	Uncharacterized conserved protein	162
643872252	392	31.71	7	392	2	385	1.0e-74	273	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
643872253	296	31.54	3	294	1	294	1.0e-35	143	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872254	200	32.69	1	197	1	205	5.0e-29	121	COG0625	Glutathione S-transferase	211
643872255	813	38.13	1	806	46	838	0.0e+00	655	COG1643	HrpA-like RNA helicase	845
643872256	767	38.37	128	713	35	606	0.0e+00	506	COG0744	Membrane carboxypeptidase (penicillin-binding protein)	661
643872257	188	30.69	2	179	1	188	3.0e-24	104	COG0693	Putative intracellular protease/amidase	188
643872258	301	34.65	1	297	1	302	1.0e-53	203	COG1893	Ketopantoate reductase	307
643872259	160	61.11	1	160	4	165	4.0e-53	200	COG1666	Uncharacterized conserved protein YajQ, UPF0234 family	165
643872261	184	44.79	23	183	1	157	2.0e-44	171	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
643872262	190	22.11	1	190	16	203	1.0e-12	66.9	COG3056	Uncharacterized lipoprotein YajG	204
643872263	378	34.88	76	376	3	298	6.0e-75	274	COG2813	16S rRNA G1207 methylase RsmC	300
643872265	102	49.43	1	86	1	87	3.0e-22	96.6	COG0271	Stress-induced morphogen (activity unknown)	90
643872266	345	38.84	3	341	1	337	6.0e-84	304	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
643872267	308	58.19	10	308	3	298	5.0e-120	424	COG4989	Predicted oxidoreductase	298
643872268	351	40.9	2	348	1	354	8.0e-83	300	COG0389	Nucleotidyltransferase/DNA polymerase involved in DNA repair	354
643872269	486	30.96	7	484	2	414	1.0e-84	307	COG2195	Di- or tripeptidase	414
643872271	576	26.67	12	554	31	496	7.0e-60	225	COG0737	2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family	517
643872272	154	21.34	1	142	14	177	5.0e-20	90.4	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	179
643872274	367	55.43	1	367	4	369	0.0e+00	483	COG0263	Glutamate 5-kinase	369
643872275	419	55.13	1	419	3	417	0.0e+00	546	COG0014	Gamma-glutamyl phosphate reductase	417
643872276	177	55.43	1	175	3	176	1.0e-65	242	COG0634	Hypoxanthine-guanine phosphoribosyltransferase	178
643872277	362	31.33	17	346	1	328	9.0e-60	224	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643872278	471	43.35	1	467	3	486	4.0e-127	448	COG1621	Sucrose-6-phosphate hydrolase SacC, GH32 family	486
643872279	456	34.76	95	451	1	374	1.0e-68	254	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
643872280	305	37.09	1	301	2	293	1.0e-74	273	COG1131	ABC-type multidrug transport system, ATPase component	293
643872281	257	20.63	6	251	16	254	6.0e-11	61.3	COG1682	ABC-type polysaccharide/polyol phosphate export permease	263
643872282	315	61.08	1	314	2	314	6.0e-121	427	COG0462	Phosphoribosylpyrophosphate synthetase	314
643872283	285	47.18	7	277	4	287	8.0e-88	317	COG1947	4-diphosphocytidyl-2C-methyl-D-erythritol kinase	289
643872284	194	31.5	1	190	4	203	5.0e-33	134	COG3017	Outer membrane lipoprotein LolB, involved in outer membrane biogenesis	206
643872285	420	47.84	3	418	2	413	5.0e-126	444	COG0373	Glutamyl-tRNA reductase	414
643872286	362	62.43	1	360	1	362	0.0e+00	525	COG0216	Protein chain release factor A	363
643872287	282	44.09	1	276	1	276	5.0e-70	258	COG2890	Methylase of polypeptide chain release factors	280
643872288	273	36.57	7	273	7	269	9.0e-44	170	COG2912	Regulator of sirC expression, contains transglutaminase-like and TPR domains	269
643872289	283	63.93	3	282	2	279	4.0e-130	457	COG2877	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase	279
643872290	441	31.34	10	286	16	287	6.0e-44	171	COG0037	tRNA(Ile)-lysidine synthase TilS/MesJ	298
643872291	574	46.52	1	570	1	500	0.0e+00	600	COG0442	Prolyl-tRNA synthetase	500
643872292	246	30	3	236	1	237	5.0e-43	168	COG1387	Histidinol phosphatase or related hydrolase of the PHP family	237
643872294	241	61.69	10	163	5	150	4.0e-49	188	COG1720	tRNA (Thr-GGU) A37 N-methylase	156
643872296	581	48.35	1	574	1	569	0.0e+00	539	COG4987	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components	573
643872297	594	48.31	23	580	1	554	0.0e+00	557	COG4988	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components	559
643872304	286	23.3	37	284	3	278	2.0e-34	140	COG4395	Predicted lipid-binding transport protein, Tim44 family	281
643872305	483	38.13	3	401	4	391	4.0e-69	255	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
643872307	480	38.69	1	395	2	388	1.0e-67	250	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
643872308	299	35.02	11	299	13	304	2.0e-58	219	COG0354	Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification	305
643872309	85	40.74	3	83	13	93	4.0e-14	69.5	COG2938	Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module	94
643872311	537	56.95	10	533	9	509	0.0e+00	704	COG0029	Aspartate oxidase	518
643872312	194	36.81	7	187	2	176	2.0e-34	139	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
643872313	190	35.6	5	185	7	188	3.0e-20	92	COG3073	Negative regulator of sigma E activity	213
643872314	320	27.27	5	317	8	315	4.0e-45	175	COG3026	Negative regulator of sigma E activity	320
643872315	153	41.83	1	152	1	150	1.0e-25	109	COG3086	Positive regulator of sigma E activity	150
643872316	598	70.23	1	597	6	603	0.0e+00	1077	COG0481	Translation elongation factor EF-4, membrane-bound GTPase	603
643872318	223	54.82	1	223	4	230	8.0e-76	276	COG0571	dsRNA-specific ribonuclease	235
643872319	300	56.52	3	300	1	298	2.0e-118	418	COG1159	GTPase Era, involved in 16S rRNA processing	298
643872320	239	33.91	7	230	8	240	6.0e-33	134	COG1381	Recombinational DNA repair protein (RecF pathway)	251
643872321	243	69.01	4	242	1	242	3.0e-95	341	COG0854	Pyridoxine 5'-phosphate synthase PdxJ	243
643872322	386	30.08	11	374	17	394	1.0e-66	247	COG0019	Diaminopimelate decarboxylase	394
643872323	282	52.31	2	281	1	279	3.0e-91	328	COG2961	23S rRNA A2030 N6-methylase RlmJ	279
643872324	645	44.92	1	522	3	530	0.0e+00	540	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
643872325	219	49.71	1	173	1	174	6.0e-41	160	COG1047	FKBP-type peptidyl-prolyl cis-trans isomerase 2	174
643872326	143	46.85	1	143	5	144	2.0e-37	148	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
643872327	174	40	1	168	1	151	5.0e-31	127	COG0716	Flavodoxin	151
643872329	261	25.47	11	260	17	282	1.0e-20	94	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
643872330	170	52.81	1	167	1	178	4.0e-49	187	COG3057	Negative regulator of replication initiation	181
643872331	549	63.43	25	548	1	524	0.0e+00	693	COG0033	Phosphoglucomutase	524
643872332	261	60.16	5	255	3	253	1.0e-95	342	COG4167	ABC-type antimicrobial peptide transport system, ATPase component	267
643872333	332	63.83	1	329	1	329	0.0e+00	498	COG4170	ABC-type antimicrobial peptide transport system, ATPase component	330
643872334	297	51.37	6	297	5	296	3.0e-85	308	COG4171	ABC-type antimicrobial peptide transport system, permease component	296
643872335	320	47.04	1	319	1	321	6.0e-80	291	COG4168	ABC-type antimicrobial peptide transport system, permease component	321
643872336	537	31.35	3	531	15	547	3.0e-77	283	COG0747	ABC-type transport system, periplasmic component	556
643872337	470	46.47	10	469	5	466	0.0e+00	463	COG3106	Predicted ATPase, YcjX-like family	467
643872338	355	39.37	32	341	31	342	2.0e-57	216	COG3768	Uncharacterized membrane protein YcjF, UPF0283 family	350
643872339	454	32.67	156	454	42	334	2.0e-39	157	COG0642	Signal transduction histidine kinase	336
643872340	229	44.54	3	229	2	228	6.0e-57	214	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
643872341	199	32.35	11	190	7	210	9.0e-24	103	COG2755	Lysophospholipase L1 or related esterase	216
643872342	226	61.4	1	226	1	228	2.0e-78	285	COG4181	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component	228
643872343	811	33.33	4	802	6	828	0.0e+00	508	COG3127	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component	829
643872344	299	47.8	3	296	1	293	2.0e-93	335	COG1090	NAD dependent epimerase/dehydratase family enzyme	297
643872346	718	56.27	395	716	1	326	1.0e-118	420	COG0280	Phosphotransacetylase	327
643872347	398	56.06	4	397	1	393	0.0e+00	562	COG0282	Acetate kinase	396
643872348	140	39.72	3	138	8	146	9.0e-25	105	COG3092	Uncharacterized membrane protein YfbV, UPF0208 family	149
643872349	248	37.75	1	248	15	257	1.0e-67	249	COG1180	Pyruvate-formate lyase-activating enzyme	260
643872350	760	66.09	10	759	9	755	0.0e+00	1094	COG1882	Pyruvate-formate lyase	755
643872351	276	48.38	6	275	2	260	9.0e-60	223	COG2116	Formate/nitrite transporter FocA, FNT family	265
643872352	584	42.14	1	417	5	396	5.0e-109	388	COG1944	Ribosomal protein S12 methylthiotransferase accessory factor YcaO	398
643872353	372	33.33	1	369	1	334	4.0e-96	344	COG0136	Aspartate-semialdehyde dehydrogenase	334
643872354	373	55.9	5	357	1	349	0.0e+00	462	COG0820	Adenine C2-methylase RlmN of 23S rRNA A2503 and tRNA A37	349
643872355	258	38.11	13	256	14	249	3.0e-46	178	COG3063	Tfp pilus assembly protein PilF	250
643872356	343	26.73	12	308	2	284	2.0e-32	133	COG1426	Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains	284
643872357	375	62.5	8	366	1	360	0.0e+00	525	COG0821	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE	361
643872358	425	50.12	2	425	1	429	0.0e+00	487	COG0124	Histidyl-tRNA synthetase	429
643872359	216	41.75	1	204	1	206	7.0e-39	153	COG2976	Putative negative regulator of RcsB-dependent stress response	207
643872360	392	27.68	40	389	41	370	7.0e-38	151	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
643872361	498	50.84	1	475	2	444	0.0e+00	577	COG1160	Predicted GTPases	444
643872363	126	76.56	1	126	1	127	9.0e-54	201	COG3445	Autonomous glycyl radical cofactor GrcA	127
643872364	223	63.47	1	219	4	222	1.0e-102	366	COG0692	Uracil DNA glycosylase	223
643872365	180	21.02	3	177	11	182	2.0e-15	75.8	COG3945	Hemerythrin-like domain	189
643872367	256	67.73	6	256	6	256	3.0e-118	418	COG4598	ABC-type histidine transport system, ATPase component	256
643872368	255	34.63	6	254	16	269	2.0e-38	152	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
643872369	246	48.98	2	246	1	228	1.0e-71	263	COG4215	ABC-type arginine transport system, permease component	230
643872370	231	53.07	2	228	1	228	1.0e-71	263	COG4160	ABC-type arginine/histidine transport system, permease component	228
643872372	268	44.98	1	267	1	259	7.0e-85	307	COG0708	Exonuclease III	261
643872375	494	46.87	1	491	5	495	0.0e+00	600	COG2317	Zn-dependent carboxypeptidase, M32 family	497
643872376	305	26.71	15	302	9	298	5.0e-38	151	COG3735	Uncharacterized conserved protein YbaP, TraB family	299
643872378	275	25.55	5	271	9	256	1.0e-36	147	COG0300	Short-chain dehydrogenase	265
643872379	469	34.78	366	467	1	115	2.0e-10	61	COG1388	LysM repeat	124
643872380	256	27.71	8	225	21	252	4.0e-23	101	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
643872382	154	56.58	3	151	2	153	4.0e-51	193	COG0328	Ribonuclease HI	154
643872383	249	37.08	3	240	9	235	2.0e-49	189	COG0847	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease	243
643872384	192	55.31	2	179	1	176	6.0e-63	233	COG0279	Phosphoheptose isomerase	176
643872385	265	48.44	1	256	1	249	6.0e-83	300	COG0121	Predicted glutamine amidotransferase	252
643872386	220	50	1	200	1	200	5.0e-80	290	COG0299	Folate-dependent phosphoribosylglycinamide formyltransferase PurN	200
643872387	345	64.93	4	345	1	345	0.0e+00	521	COG0150	Phosphoribosylaminoimidazole (AIR) synthetase	345
643872388	208	62.2	1	208	2	210	1.0e-79	289	COG0035	Uracil phosphoribosyltransferase	210
643872390	468	41.27	5	461	26	477	1.0e-102	366	COG4783	Putative Zn-dependent protease, contains TPR repeats	484
643872391	358	30.95	4	350	1	345	1.0e-34	140	COG0628	Predicted PurR-regulated permease PerM	355
643872392	280	36.88	2	280	25	304	2.0e-49	189	COG3118	Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains	304
643872394	626	39.15	13	622	9	597	0.0e+00	517	COG3083	Membrane-anchored periplasmic protein YejM, alkaline phosphatase superfamily	600
643872395	77	49.32	1	73	1	73	1.0e-12	65	COG3082	Uncharacterized conserved protein YejL, UPF0352 family	74
643872396	343	42.86	1	342	1	334	5.0e-91	328	COG3081	Nucleoid-associated protein YejK (function unknown)	335
643872397	195	34.55	5	195	4	191	9.0e-44	169	COG0212	5-formyltetrahydrofolate cyclo-ligase	191
643872398	108	41.49	6	99	2	95	1.0e-13	68	COG3027	Cell division protein ZapA, inhibits GTPase activity of FtsZ	105
643872399	203	37.97	19	203	3	186	2.0e-29	121	COG3079	Uncharacterized conserved protein YgfB, UPF0149 family	186
643872400	396	35.71	7	393	2	384	6.0e-68	251	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
643872401	396	37.76	2	386	1	384	1.0e-66	247	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
643872402	275	24.89	28	245	5	219	5.0e-16	78.5	COG1484	DNA replication protein DnaC	254
643872405	304	57.09	8	303	4	291	1.0e-116	413	COG1210	UTP-glucose-1-phosphate uridylyltransferase	291
643872407	252	49.42	2	251	4	262	4.0e-73	267	COG1218	3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase	276
643872408	98	50	1	98	1	92	6.0e-23	98.8	COG2350	Uncharacterized conserved protein YciI, contains a putative active-site phosphohistidine	92
643872409	182	50.84	1	179	1	179	3.0e-52	197	COG2917	Intracellular septation protein A	180
643872410	268	44.74	1	266	1	263	2.0e-80	292	COG0159	Tryptophan synthase alpha chain	265
643872411	397	69.11	1	395	2	395	0.0e+00	687	COG0133	Tryptophan synthase beta chain	396
643872412	460	55.34	12	259	1	253	6.0e-86	311	COG0134	Indole-3-glycerol phosphate synthase	254
643872413	336	50.6	5	335	8	338	3.0e-108	384	COG0547	Anthranilate phosphoribosyltransferase	338
643872414	199	46.32	5	190	4	189	2.0e-60	225	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
643872415	542	39.8	13	521	3	461	5.0e-126	445	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
643872416	287	47.47	1	257	2	254	5.0e-61	228	COG0613	Predicted metal-dependent phosphoesterase TrpH, contains PHP domain	258
643872417	206	44.17	2	206	1	205	3.0e-56	211	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
643872418	348	51.79	1	244	1	247	1.0e-69	257	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
643872419	232	50.46	5	220	2	215	8.0e-78	283	COG0603	7-cyano-7-deazaguanine synthase (queuosine biosynthesis)	222
643872420	150	61.7	6	146	17	157	8.0e-55	206	COG1956	GAF domain-containing protein, putative methionine-R-sulfoxide reductase	163
643872427	453	44.04	24	450	27	456	2.0e-109	389	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
643872431	91	68.89	1	90	1	90	2.0e-35	140	COG2924	Fe-S cluster biosynthesis and repair protein YggX	90
643872432	363	51.32	17	356	9	337	8.0e-112	397	COG1194	Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs	342
643872433	241	53.12	20	239	1	224	2.0e-73	268	COG0220	tRNA G46 methylase TrmB	227
643872434	381	43.64	6	381	34	412	2.0e-110	392	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
643872435	196	53.3	1	196	1	192	2.0e-63	235	COG0127	Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family	194
643872436	96	49.47	1	91	3	97	1.0e-23	101	COG1872	Uncharacterized conserved protein YggU, UPF0235/DUF167 family	102
643872438	274	43.7	3	271	1	264	1.0e-65	243	COG0345	Pyrroline-5-carboxylate reductase	266
643872439	233	56.03	2	232	1	228	7.0e-81	293	COG0325	Uncharacterized pyridoxal phosphate-containing protein, affects Ilv metabolism, UPF0001 family	228
643872440	345	67.93	1	342	3	345	0.0e+00	547	COG2805	Tfp pilus assembly protein PilT, pilus retraction ATPase	353
643872441	368	54.05	1	368	5	374	0.0e+00	475	COG5008	Tfp pilus assembly protein, ATPase PilU	375
643872442	260	63.04	1	257	1	253	2.0e-89	322	COG3022	Cytoplasmic iron level regulating protein YaaA, DUF328/UPF0246 family	253
643872443	438	41.1	1	434	29	460	2.0e-105	376	COG0513	Superfamily II DNA and RNA helicase	513
643872444	265	38.82	34	263	13	248	9.0e-56	210	COG4123	tRNA1(Val) A37 N6-methylase TrmN6	248
643872445	172	36.69	1	167	2	150	7.0e-30	123	COG0716	Flavodoxin	151
643872446	297	58.86	1	297	2	300	8.0e-114	403	COG4974	Site-specific recombinase XerD	300
643872448	575	41.19	34	552	1	491	3.0e-111	396	COG0608	Single-stranded DNA-specific exonuclease, DHH superfamily, may be involved in archaeal DNA replication intiation	491
643872449	365	63.18	128	365	1	239	8.0e-97	347	COG1186	Protein chain release factor B	239
643872450	513	60.52	15	510	8	500	0.0e+00	727	COG1190	Lysyl-tRNA synthetase (class II)	502
643872451	530	41.68	1	530	3	530	0.0e+00	589	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
643872452	442	39.78	6	441	1	436	0.0e+00	477	COG0621	tRNA A37 methylthiotransferase MiaB	437
643872453	135	44.25	8	120	16	128	9.0e-29	119	COG4273	Uncharacterized protein, contains metal-binding DGC domain	135
643872454	195	19.64	16	180	20	168	2.0e-10	59.2	COG1853	NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family	176
643872455	140	34.95	22	124	9	108	2.0e-08	51.5	COG1846	DNA-binding transcriptional regulator, MarR family	126
643872457	154	29.03	10	102	7	98	9.0e-07	46.4	COG4541	Uncharacterized membrane protein	100
643872459	475	45.7	3	474	2	456	0.0e+00	565	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
643872460	300	26.42	7	298	3	291	6.0e-35	141	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872461	268	31.23	1	243	3	264	9.0e-40	157	COG0289	Dihydrodipicolinate reductase	266
643872462	366	28.65	1	363	3	384	9.0e-45	174	COG1252	NADH dehydrogenase, FAD-containing subunit	405
643872463	204	23.37	17	196	4	184	6.0e-09	54.2	COG0558	Phosphatidylglycerophosphate synthase	192
643872464	214	57	1	207	2	207	3.0e-67	247	COG4136	ABC-type uncharacterized transport system YnjBCD, ATPase component	213
643872465	554	37.18	29	553	5	549	4.0e-84	305	COG4135	ABC-type uncharacterized transport system YnjBCD, permease component	551
643872466	391	51.02	3	391	2	383	2.0e-101	362	COG4134	ABC-type uncharacterized transport system YnjBCD, periplasmic component	384
643872467	717	37.72	232	691	3	454	6.0e-112	398	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
643872468	724	68.32	5	723	11	729	0.0e+00	1164	COG0376	Catalase (peroxidase I)	730
643872469	327	29.22	2	325	1	326	7.0e-55	207	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
643872470	212	16.93	16	202	4	192	1.0e-13	70.1	COG1309	DNA-binding transcriptional regulator, AcrR family	201
643872472	352	53.7	29	188	1	162	3.0e-62	232	COG0225	Peptide methionine sulfoxide reductase MsrA	174
643872473	129	37.96	18	125	14	121	1.0e-17	82.1	COG0818	Diacylglycerol kinase	123
643872474	533	23.96	88	304	22	232	7.0e-08	52.5	COG0671	Membrane-associated phospholipid phosphatase	232
643872478	347	30.62	50	347	10	316	3.0e-49	189	COG0701	Uncharacterized membrane protein YraQ, UPF0718 family	317
643872479	182	29.56	11	160	17	175	2.0e-20	92.5	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
643872480	357	42.18	16	352	8	336	1.0e-76	280	COG0798	Arsenite efflux pump ArsB, ACR3 family	342
643872481	142	44.74	5	118	2	114	8.0e-26	109	COG2832	Uncharacterized membrane protein YbaN, DUF454 family	119
643872484	308	34.47	3	308	1	309	8.0e-57	214	COG0524	Sugar or nucleoside kinase, ribokinase family	311
643872485	421	21.96	4	413	14	433	2.0e-27	117	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
643872486	291	41.18	1	289	3	288	3.0e-58	218	COG1175	ABC-type sugar transport system, permease component	295
643872487	303	37.08	39	302	19	281	5.0e-50	191	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
643872488	484	36.94	6	457	27	464	1.0e-95	343	COG1621	Sucrose-6-phosphate hydrolase SacC, GH32 family	486
643872489	375	54.8	1	354	1	338	1.0e-127	449	COG3839	ABC-type sugar transport system, ATPase component	338
643872490	338	32.54	2	329	1	328	4.0e-61	228	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643872492	479	46.25	1	478	3	477	0.0e+00	555	COG0469	Pyruvate kinase	477
643872493	283	42.65	1	278	3	281	4.0e-69	254	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
643872494	321	58.15	5	316	8	320	9.0e-122	430	COG0837	Glucokinase	320
643872497	204	48.53	1	203	3	205	5.0e-57	214	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	205
643872498	270	55.06	3	269	1	266	3.0e-96	344	COG0289	Dihydrodipicolinate reductase	266
643872499	376	62.53	5	375	4	366	0.0e+00	580	COG0505	Carbamoylphosphate synthase small subunit	368
643872500	1075	69.44	13	408	1	393	0.0e+00	584	COG0458	Carbamoylphosphate synthase large subunit	400
643872501	287	56.84	1	284	1	285	4.0e-73	268	COG5006	Threonine/homoserine efflux transporter RhtA	292
643872503	199	23.2	4	197	9	196	2.0e-11	62.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
643872504	483	32.89	25	480	1	448	4.0e-57	216	COG1538	Outer membrane protein TolC	457
643872505	402	41.32	22	384	8	343	3.0e-74	272	COG1566	Multidrug resistance efflux pump	352
643872507	275	22.96	6	273	1	213	6.0e-14	71.5	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
643872508	690	43.74	2	687	8	693	0.0e+00	642	COG1523	Pullulanase/glycogen debranching enzyme	697
643872509	468	29.98	1	386	2	390	5.0e-49	188	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
643872511	466	37.2	8	456	11	467	7.0e-94	337	COG2211	Na+/melibiose symporter or related transporter	467
643872512	277	33.9	160	277	9	126	4.0e-19	88.8	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643872513	104	52.38	1	104	1	105	5.0e-34	135	COG3254	L-rhamnose mutarotase	105
643872515	419	78.52	1	419	1	419	0.0e+00	708	COG4806	L-rhamnose isomerase	419
643872516	496	24.22	1	466	2	474	1.0e-78	287	COG1070	Sugar (pentulose or hexulose) kinase	502
643872517	275	32.2	158	275	8	125	2.0e-20	93	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643872518	383	46.68	7	383	6	377	6.0e-111	394	COG1454	Alcohol dehydrogenase, class IV	377
643872520	796	45.63	21	794	2	774	0.0e+00	917	COG0466	ATP-dependent Lon protease, bacterial type	782
643872521	505	66	7	501	2	489	0.0e+00	689	COG2719	Stage V sporulation protein SpoVR/YcgB, involved in spore cortex formation (function unknown)	495
643872522	422	60.43	1	420	1	418	0.0e+00	525	COG2718	Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family	423
643872523	641	69.03	1	640	1	648	0.0e+00	883	COG2766	Predicted Ser/Thr protein kinase	649
643872525	822	46	11	818	3	750	0.0e+00	821	COG0058	Glucan phosphorylase	750
643872526	240	39.69	1	193	1	188	3.0e-51	195	COG0307	Riboflavin synthase alpha chain	204
643872527	416	46.56	1	415	29	448	7.0e-112	397	COG0513	Superfamily II DNA and RNA helicase	513
643872533	270	31.82	28	269	7	226	6.0e-17	81.6	COG2801	Transposase InsO and inactivated derivatives	232
643872534	114	31.48	8	114	3	104	4.0e-07	47.1	COG2963	Transposase and inactivated derivatives	116
643872538	227	37.72	1	223	1	226	2.0e-38	152	COG1011	FMN phosphatase YigB, HAD superfamily	229
643872540	169	46.47	1	169	3	171	2.0e-47	182	COG3040	Bacterial lipocalin	174
643872543	672	37.65	21	645	1	646	0.0e+00	468	COG1199	Rad3-related DNA helicase	654
643872544	235	36.91	1	230	1	219	2.0e-39	156	COG1214	tRNA A37 threonylcarbamoyladenosine modification protein TsaB	220
643872545	170	31.88	1	160	9	164	1.0e-24	106	COG3065	Starvation-inducible outer membrane lipoprotein	191
643872546	615	68.79	143	579	1	428	0.0e+00	759	COG0422	Thiamine biosynthesis protein ThiC	432
643872547	218	42.93	15	212	16	211	2.0e-52	198	COG0352	Thiamine monophosphate synthase	211
643872548	264	46.43	3	246	1	252	5.0e-60	224	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
643872549	66	37.88	1	66	3	68	3.0e-12	63.7	COG2104	Sulfur carrier protein ThiS (thiamine biosynthesis)	68
643872550	259	61.81	4	256	7	260	6.0e-98	350	COG2022	Thiamin biosynthesis thiazole synthase ThiGH, ThiG subunit	262
643872551	380	23.71	16	365	1	355	3.0e-65	242	COG1060	2-iminoacetate synthase ThiH (tyrosine cleavage enzyme, thamine biosynthesis)	370
643872552	126	25.26	8	100	11	105	7.0e-08	49.6	COG1366	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	117
643872554	436	45.35	1	432	1	440	3.0e-108	385	COG0544	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)	441
643872555	207	75.65	15	207	2	194	4.0e-90	323	COG0740	ATP-dependent protease ClpP, protease subunit	200
643872556	426	72.37	17	425	1	407	0.0e+00	707	COG1219	ATP-dependent protease Clp, ATPase subunit	408
643872557	782	70.84	2	780	1	781	0.0e+00	1195	COG0466	ATP-dependent Lon protease, bacterial type	782
643872558	90	60	1	90	2	91	2.0e-27	113	COG0776	Bacterial nucleoid DNA-binding protein	94
643872560	180	49.76	1	179	1	207	1.0e-51	196	COG3109	sRNA-binding protein	208
643872561	669	35.91	124	561	1	397	2.0e-90	327	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	406
643872562	394	70.3	1	393	1	393	0.0e+00	613	COG0027	Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase)	394
643872563	159	41.57	2	154	1	166	4.0e-41	161	COG0350	O6-methylguanine-DNA--protein-cysteine methyltransferase	168
643872564	466	47.44	1	465	2	434	0.0e+00	537	COG0017	Aspartyl/asparaginyl-tRNA synthetase	435
643872566	444	43.31	2	435	1	439	3.0e-128	452	COG1486	Alpha-galactosidase/6-phospho-beta-glucosidase, family 4 of glycosyl hydrolase	442
643872567	339	25.16	7	305	2	296	2.0e-34	139	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872568	427	47.39	1	421	3	443	0.0e+00	551	COG0161	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	449
643872569	355	59.63	6	330	11	335	2.0e-125	442	COG0502	Biotin synthase or related enzyme	335
643872570	383	45.03	3	378	5	386	4.0e-112	398	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
643872572	227	44.93	1	227	1	222	2.0e-64	239	COG0132	Dethiobiotin synthetase	223
643872573	291	31.31	1	291	15	297	6.0e-45	174	COG0501	Zn-dependent protease with chaperone function	302
643872574	217	60.91	12	208	2	197	2.0e-79	288	COG0108	3,4-dihydroxy-2-butanone 4-phosphate synthase	203
643872575	579	32.66	9	579	7	594	2.0e-99	356	COG0729	Outer membrane translocation and assembly module TamA	594
643872576	1240	26.32	6	1240	12	1278	0.0e+00	508	COG2911	Autotransporter translocation and assembly factor TamB	1278
643872577	569	33.26	4	448	1	415	4.0e-61	229	COG0446	NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase	415
643872578	425	52.19	1	424	16	446	0.0e+00	512	COG0160	4-aminobutyrate aminotransferase or related aminotransferase	447
643872579	487	47.74	20	482	8	466	0.0e+00	514	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
643872580	308	21.55	16	308	2	293	8.0e-29	121	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872581	274	40.6	5	270	1	266	2.0e-57	216	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
643872582	419	43.61	193	419	60	286	8.0e-63	234	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
643872583	344	24.72	6	342	16	363	2.0e-47	183	COG0687	Spermidine/putrescine-binding periplasmic protein	363
643872584	364	46.8	3	360	1	350	6.0e-116	410	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
643872585	317	47.2	157	317	1	161	8.0e-49	187	COG3272	Uncharacterized conserved protein YbgA, DUF1722 family	163
643872586	465	48.51	1	464	2	458	0.0e+00	481	COG0415	Deoxyribodipyrimidine photolyase	461
643872591	669	70.12	1	666	1	659	0.0e+00	1116	COG0556	Excinuclease UvrABC helicase subunit UvrB	663
643872592	216	45.08	24	214	1	190	1.0e-62	232	COG0302	GTP cyclohydrolase I	195
643872593	506	59.91	43	505	10	473	0.0e+00	663	COG2925	Exonuclease I	475
643872595	149	30.07	1	134	20	162	4.0e-07	47.3	COG2391	Uncharacterized membrane protein YedE/YeeE, contains two sulfur transport domains	198
643872596	166	51.81	1	166	5	168	1.0e-43	169	COG3013	Uncharacterized protein YfbU, UPF0304 family	168
643872598	330	28.9	7	265	4	258	4.0e-26	112	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
643872601	155	50.32	1	155	1	155	8.0e-55	206	COG1225	Peroxiredoxin	157
643872602	292	48.46	1	292	4	296	2.0e-83	302	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
643872603	507	22.67	16	354	12	338	2.0e-27	117	COG3317	Uncharacterized lipoprotein	342
643872605	228	27.94	12	213	41	241	1.0e-27	116	COG1876	LD-carboxypeptidase LdcB, LAS superfamily	241
643872606	380	34.86	6	376	15	407	2.0e-82	299	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
643872607	115	33.04	1	110	1	111	2.0e-25	107	COG1393	Arsenate reductase and related proteins, glutaredoxin family	117
643872609	341	26.47	132	335	2	190	1.0e-23	104	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
643872612	324	28.33	1	298	1	294	5.0e-41	161	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872613	410	58.05	1	410	1	384	0.0e+00	516	COG1979	Alcohol dehydrogenase YqhD, Fe-dependent ADH family	384
643872616	326	37.29	11	309	7	303	3.0e-45	176	COG5377	Phage-related protein, predicted endonuclease	319
643872623	443	25.62	25	415	13	402	6.0e-30	125	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
643872624	357	17.08	31	296	12	284	6.0e-14	72.3	COG1566	Multidrug resistance efflux pump	352
643872628	1123	31.48	204	1096	13	873	0.0e+00	522	COG4096	Type I site-specific restriction endonuclease, part of a restriction-modification system	875
643872629	513	24.39	1	513	2	481	5.0e-50	192	COG0286	Type I restriction-modification system, DNA methylase subunit	489
643872630	371	20.97	3	352	1	367	3.0e-23	103	COG0732	Restriction endonuclease S subunit	391
643872646	260	41.46	8	251	1	246	2.0e-58	218	COG1414	DNA-binding transcriptional regulator, IclR family	246
643872647	401	33.05	66	401	32	370	2.0e-61	230	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
643872648	429	19.58	10	376	24	395	3.0e-17	83.3	COG2271	Sugar phosphate permease	448
643872649	268	61.96	2	256	1	255	1.0e-101	363	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	255
643872650	383	46.42	7	383	6	377	8.0e-110	390	COG1454	Alcohol dehydrogenase, class IV	377
643872652	805	40.08	2	453	1	461	3.0e-93	337	COG0286	Type I restriction-modification system, DNA methylase subunit	489
643872653	348	50.62	106	267	1	159	4.0e-40	158	COG4804	Predicted nuclease of restriction endonuclease-like (RecB) superfamily,  DUF1016 family	159
643872654	445	21.58	24	433	1	391	9.0e-25	108	COG0732	Restriction endonuclease S subunit	391
643872657	1030	24.71	8	1008	4	960	1.0e-118	421	COG0610	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ...	962
643872658	238	27.36	15	226	17	213	4.0e-31	128	COG1451	Predicted metal-dependent hydrolase	223
643872659	1013	19.09	213	901	3	655	1.0e-31	132	COG0210	Superfamily I DNA or RNA helicase	655
643872661	327	28.91	3	323	9	344	1.0e-43	170	COG3177	Fic family protein	348
643872662	406	38.89	227	406	4	181	1.0e-37	151	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643872663	566	60.49	3	562	2	560	0.0e+00	651	COG2060	K+-transporting ATPase, A chain	560
643872664	688	70.25	2	688	1	681	0.0e+00	1049	COG2216	High-affinity K+ transport system, ATPase chain B	681
643872665	190	47.09	1	183	2	190	2.0e-52	198	COG2156	K+-transporting ATPase, c chain	190
643872666	897	53.54	5	889	1	886	0.0e+00	1006	COG2205	K+-sensing histidine kinase KdpD	890
643872667	231	42.11	7	231	2	228	9.0e-58	216	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
643872668	288	35	16	155	7	130	6.0e-26	111	COG2005	DNA-binding transcriptional regulator ModE (molybdenum-dependent)	130
643872669	251	33.77	23	249	29	254	2.0e-44	172	COG0725	ABC-type molybdate transport system, periplasmic component	258
643872670	142	39.71	1	68	1	68	2.0e-08	51.5	COG3585	Molybdopterin-binding protein	69
643872672	174	40.27	12	157	12	158	6.0e-19	87	COG1495	Disulfide bond formation protein DsbB	170
643872673	93	52.87	1	87	1	87	1.0e-27	114	COG1342	Predicted DNA-binding protein, UPF0251 family	99
643872674	140	49.63	3	137	9	140	3.0e-35	140	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
643872675	179	25.62	1	113	1	121	6.0e-09	54.1	COG1433	Predicted Fe-Mo cluster-binding protein, NifX family	121
643872676	147	26.5	27	138	24	139	1.0e-09	55.8	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
643872677	282	36.36	6	265	2	246	6.0e-49	187	COG1237	Metal-dependent hydrolase, beta-lactamase superfamily II	259
643872678	474	31.73	4	451	2	454	4.0e-73	269	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
643872680	238	29.46	5	237	14	253	8.0e-26	110	COG0725	ABC-type molybdate transport system, periplasmic component	258
643872681	277	29.89	1	266	1	269	2.0e-52	199	COG0157	Nicotinate-nucleotide pyrophosphorylase	280
643872683	318	27.35	76	315	18	249	2.0e-39	156	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
643872686	109	69.72	1	109	3	111	6.0e-44	168	COG2920	Sulfur relay (sulfurtransferase) protein, DsrC/TusE family	111
643872687	724	25.7	7	641	1	604	2.0e-69	257	COG1289	Uncharacterized membrane protein YccC	674
643872689	567	31.99	6	564	1	489	1.0e-92	334	COG0286	Type I restriction-modification system, DNA methylase subunit	489
643872690	437	21.83	69	424	55	391	6.0e-19	88.9	COG0732	Restriction endonuclease S subunit	391
643872691	309	34.98	6	307	9	299	8.0e-57	214	COG2958	Uncharacterized protein	307
643872692	1074	33.46	1	1045	1	962	0.0e+00	634	COG0610	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ...	962
643872694	282	35.55	50	243	54	264	3.0e-27	115	COG0790	TPR repeat	292
643872696	211	37.44	8	202	78	288	2.0e-42	165	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
643872697	342	26.82	4	258	1	256	4.0e-23	102	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
643872698	397	58.85	14	397	15	397	0.0e+00	477	COG4597	ABC-type amino acid transport system, permease component	397
643872699	365	36.56	137	363	1	222	4.0e-48	185	COG0765	ABC-type amino acid transport system, permease component	222
643872700	250	62.5	9	248	2	240	6.0e-116	410	COG1126	ABC-type polar amino acid transport system, ATPase component	240
643872701	558	42.75	13	513	1	486	3.0e-102	366	COG0366	Glycosidase	505
643872702	555	42.15	15	517	1	497	8.0e-109	388	COG0366	Glycosidase	505
643872703	371	51.54	1	357	1	338	1.0e-123	436	COG3839	ABC-type sugar transport system, ATPase component	338
643872704	281	39.86	4	280	2	281	2.0e-56	212	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
643872705	333	37.83	29	330	1	294	3.0e-67	249	COG1175	ABC-type sugar transport system, permease component	295
643872706	422	26.91	5	419	11	432	2.0e-40	160	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
643872707	308	23.18	5	304	6	295	2.0e-29	123	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872708	110	37.08	4	91	1	88	8.0e-15	72.2	COG1264	Phosphotransferase system IIB components	88
643872710	253	44.09	3	251	2	251	1.0e-50	193	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643872714	245	19.37	1	191	6	187	1.0e-05	43.8	COG2834	Outer membrane lipoprotein-sorting protein	211
643872715	414	26.06	4	411	5	405	2.0e-40	160	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
643872716	229	47.75	3	223	1	221	2.0e-72	265	COG1136	ABC-type lipoprotein export system, ATPase component	226
643872717	368	24.62	18	342	3	247	5.0e-43	168	COG0152	Phosphoribosylaminoimidazole-succinocarboxamide synthase	247
643872718	146	42.14	6	144	1	140	8.0e-42	162	COG0816	RNase H-fold protein, predicted Holliday junction resolvase in Firmicutes and mycoplasms, involved in anti-termination at Rho-dependent terminators	141
643872719	185	48.39	2	185	10	194	6.0e-56	210	COG1678	Putative transcriptional regulator, AlgH/UPF0301 family	194
643872720	318	44.04	3	317	1	318	5.0e-79	288	COG0189	Glutathione synthase/RimK-type ligase, ATP-grasp superfamily	318
643872721	243	48.18	1	241	1	246	2.0e-73	268	COG1385	16S rRNA U1498 N3-methylase RsmE	246
643872722	199	59.59	2	194	35	226	3.0e-71	261	COG2356	Endonuclease I	237
643872724	174	43.75	19	162	9	151	4.0e-35	140	COG3091	Predicted Zn-dependent metalloprotease, SprT family	156
643872725	384	72.54	1	383	3	388	0.0e+00	694	COG0192	S-adenosylmethionine synthetase	388
643872726	666	66.62	1	663	3	661	0.0e+00	1080	COG0021	Transketolase	663
643872727	387	58.4	1	386	2	395	0.0e+00	497	COG0126	3-phosphoglycerate kinase	395
643872728	358	35.67	17	356	5	284	1.0e-86	313	COG0191	Fructose/tagatose bisphosphate aldolase	286
643872729	714	35.65	12	700	15	697	0.0e+00	561	COG2274	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	709
643872730	461	19.47	28	407	14	296	3.0e-11	63.4	COG1566	Multidrug resistance efflux pump	352
643872731	433	24.75	22	422	41	448	2.0e-42	166	COG1538	Outer membrane protein TolC	457
643872732	241	20.97	21	204	14	191	4.0e-26	111	COG3672	Predicted transglutaminase-like cysteine proteinase	191
643872733	640	27.9	404	632	1	233	6.0e-28	119	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
643872738	197	63.02	4	195	3	193	7.0e-73	266	COG0807	GTP cyclohydrolase II	193
643872742	159	17.75	1	157	12	170	9.0e-08	50	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
643872744	633	21.52	7	609	16	621	1.0e-41	164	COG1368	Phosphoglycerol transferase MdoB or a related enzyme of AlkP superfamily	650
643872745	845	30.23	344	696	1	327	2.0e-43	171	COG0642	Signal transduction histidine kinase	336
643872746	1293	38.92	33	954	8	845	0.0e+00	782	COG1643	HrpA-like RNA helicase	845
643872748	68	61.54	5	68	3	67	9.0e-21	91.7	COG1278	Cold shock protein, CspA family	67
643872749	574	37.48	3	570	2	565	9.0e-109	387	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
643872750	586	32.24	1	577	1	567	2.0e-115	410	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
643872751	265	43.13	5	262	16	276	5.0e-71	261	COG3770	Murein endopeptidase	284
643872752	323	22.73	1	297	4	331	4.0e-18	85.7	COG0673	Predicted dehydrogenase	342
643872753	147	49.19	1	124	3	109	5.0e-31	126	COG1970	Large-conductance mechanosensitive channel	130
643872755	109	22.34	2	90	13	106	6.0e-06	42.6	COG0526	Thiol-disulfide isomerase or thioredoxin	127
643872757	91	27.78	12	80	3	71	4.0e-06	43	COG0695	Glutaredoxin	80
643872758	439	36.01	1	432	3	429	4.0e-100	358	COG1253	Hemolysin or related protein, contains CBS domains	429
643872763	162	29.7	1	159	5	168	5.0e-23	100	COG1432	Uncharacterized conserved protein, LabA/DUF88 family	181
643872764	530	43.29	10	530	24	549	0.0e+00	531	COG4716	Myosin-crossreactive antigen  (function unknown)	587
643872766	218	36.45	3	216	2	207	4.0e-30	124	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
643872768	209	33.5	1	202	1	203	7.0e-30	123	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
643872769	150	26.49	1	139	17	160	5.0e-08	50.8	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
643872770	316	26.22	35	311	3	286	4.0e-37	148	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
643872772	140	26.28	5	131	3	137	1.0e-10	59.1	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
643872775	98	43.02	13	98	9	94	5.0e-17	79.2	COG4453	Uncharacterized conserved protein, DUF1778 family	95
643872777	279	40.93	1	278	8	281	6.0e-69	254	COG2897	3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains	285
643872781	239	24.56	2	146	3	166	1.0e-07	50.4	COG1432	Uncharacterized conserved protein, LabA/DUF88 family	181
643872783	275	35.56	1	274	2	285	3.0e-58	218	COG2996	Predicted RNA-binding protein, contains S1 domains,  virulence factor B family	287
643872784	543	49.16	366	543	4	181	9.0e-51	195	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643872785	182	54.71	1	170	1	170	5.0e-59	220	COG4681	Uncharacterized conserved protein YaeQ, suppresses RfaH defect	181
643872786	329	31.95	1	316	3	336	5.0e-55	208	COG0673	Predicted dehydrogenase	342
643872787	751	16.89	1	725	1	647	4.0e-28	120	COG2982	Uncharacterized protein involved in outer membrane biogenesis	648
643872788	783	50.38	1	783	2	736	0.0e+00	763	COG0574	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase	740
643872789	140	28.24	1	129	1	131	8.0e-17	79.7	COG3187	Heat shock protein HslJ	142
643872790	444	29.05	1	444	2	438	2.0e-77	283	COG4097	Predicted ferric reductase	438
643872791	504	46.45	176	357	1	181	2.0e-46	180	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643872792	451	34.12	28	449	24	436	2.0e-65	243	COG1322	DNA anti-recombination protein (rearrangement mutator) RmuC	448
643872795	300	30.95	5	294	2	288	5.0e-45	174	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872796	341	20.08	146	335	74	306	5.0e-12	65.7	COG0657	Acetyl esterase/lipase	312
643872797	538	31.14	32	522	4	475	4.0e-87	315	COG2272	Carboxylesterase type B	491
643872798	584	34.1	65	578	4	486	4.0e-95	342	COG2272	Carboxylesterase type B	491
643872800	351	23.62	47	351	17	298	2.0e-22	100	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
643872801	283	31.36	168	283	6	123	6.0e-19	88.1	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	124
643872802	283	46.95	1	275	3	280	7.0e-99	353	COG0656	Aldo/keto reductase, related to diketogulonate reductase	280
643872803	302	29.93	1	295	6	307	2.0e-42	166	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
643872804	421	23.62	1	414	5	433	1.0e-34	140	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
643872805	373	43.04	137	373	58	292	1.0e-59	223	COG1175	ABC-type sugar transport system, permease component	295
643872806	299	36.7	7	298	2	281	3.0e-51	195	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
643872807	375	57.1	1	352	1	336	4.0e-127	448	COG3839	ABC-type sugar transport system, ATPase component	338
643872808	643	21	107	600	27	490	9.0e-38	152	COG0366	Glycosidase	505
643872810	269	35.88	1	250	3	263	2.0e-42	166	COG0388	Predicted amidohydrolase	274
643872811	457	24.89	24	453	16	456	1.0e-31	131	COG0531	Amino acid transporter	466
643872813	169	41.18	1	152	1	153	2.0e-39	154	COG4702	Uncharacterized protein, UPF0303 family	168
643872815	423	38.67	243	421	2	181	3.0e-43	169	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643872818	365	25.58	6	348	9	343	7.0e-31	128	COG0628	Predicted PurR-regulated permease PerM	355
643872819	207	32.62	11	196	15	201	2.0e-34	139	COG3218	ABC-type uncharacterized transport system, auxiliary component	205
643872820	312	24.35	1	300	1	301	2.0e-29	123	COG1463	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, periplasmic component MlaD	359
643872821	264	52.51	1	259	1	259	1.0e-95	342	COG1127	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, ATPase component MlaF	263
643872822	381	38.95	115	381	6	267	5.0e-59	221	COG0767	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, permease component MlaE	267
643872823	224	45.25	4	222	1	220	4.0e-65	241	COG1136	ABC-type lipoprotein export system, ATPase component	226
643872824	414	27.13	1	413	3	408	2.0e-60	226	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
643872825	341	25.5	7	330	18	366	8.0e-19	88.3	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
643872828	325	19.61	14	320	1	289	1.0e-44	173	COG1518	CRISPR/Cas system-associated endonuclease Cas1	327
643872834	361	56.71	1	361	3	365	0.0e+00	481	COG1932	Phosphoserine aminotransferase	365
643872835	427	47.59	1	427	1	427	0.0e+00	487	COG0128	5-enolpyruvylshikimate-3-phosphate synthase	428
643872836	410	43.37	8	336	1	324	8.0e-90	324	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
643872837	198	22.45	1	181	5	198	1.0e-16	79.9	COG1011	FMN phosphatase YigB, HAD superfamily	229
643872838	402	54.04	9	402	3	394	0.0e+00	533	COG0282	Acetate kinase	396
643872839	606	38.35	3	602	2	574	0.0e+00	530	COG1966	Carbon starvation protein CstA	575
643872840	238	45.9	1	238	1	244	2.0e-52	199	COG3279	DNA-binding response regulator, LytR/AlgR family	244
643872841	573	54.59	5	569	1	555	0.0e+00	684	COG3275	Sensor histidine kinase, LytS/YehU family	557
643872842	333	42.43	4	333	14	345	4.0e-71	261	COG1744	Basic membrane lipoprotein Med, periplasmic binding protein (PBP1-ABC) superfamily	345
643872843	520	53.6	7	505	3	500	0.0e+00	630	COG3845	ABC-type uncharacterized transport system, ATPase component	501
643872844	368	42.61	14	357	16	350	5.0e-69	255	COG4603	ABC-type uncharacterized transport system, permease component	356
643872845	321	51.88	1	320	3	304	3.0e-77	282	COG1079	ABC-type uncharacterized transport system, permease component	304
643872846	355	59.03	2	349	1	348	0.0e+00	532	COG0722	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	351
643872847	375	27.05	100	353	4	279	4.0e-49	189	COG0287	Prephenate dehydrogenase	279
643872848	333	41.21	19	331	12	321	3.0e-85	309	COG2358	TRAP-type uncharacterized transport system, periplasmic component	321
643872849	384	44.16	1	375	1	384	2.0e-115	409	COG1168	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	388
643872850	389	19.95	16	384	17	383	3.0e-10	59.8	COG2814	Predicted arabinose efflux permease, MFS family	394
643872851	318	23.79	7	290	2	288	2.0e-23	103	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872852	339	30.23	34	333	2	310	5.0e-50	191	COG0616	Periplasmic serine protease, ClpP class	317
643872853	869	47.79	3	583	1	555	0.0e+00	654	COG0550	DNA topoisomerase IA	570
643872856	188	22.58	26	142	8	126	2.0e-07	48.8	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
643872857	456	39.69	7	453	4	454	2.0e-128	452	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
643872858	460	44.59	1	453	2	450	0.0e+00	463	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
643872860	675	32.56	62	403	1	330	2.0e-41	164	COG0642	Signal transduction histidine kinase	336
643872861	468	34.93	1	434	29	462	2.0e-96	346	COG0513	Superfamily II DNA and RNA helicase	513
643872862	349	68.48	1	348	2	350	0.0e+00	584	COG0722	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	351
643872863	216	34.56	4	212	3	214	3.0e-36	145	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
643872864	452	33.93	4	450	12	451	7.0e-66	245	COG0534	Na+-driven multidrug efflux pump	455
643872866	289	35.03	1	289	1	286	7.0e-48	184	COG3001	Fructosamine-3-kinase	286
643872867	385	58.22	6	375	4	374	0.0e+00	479	COG5008	Tfp pilus assembly protein, ATPase PilU	375
643872868	294	26.12	158	291	7	137	6.0e-08	51.7	COG2510	Uncharacterized membrane protein	140
643872869	231	39.08	1	230	3	240	3.0e-60	224	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
643872870	203	35.47	2	203	1	203	8.0e-43	167	COG1739	Putative translation regulator, IMPACT (imprinted ancient) protein family	203
643872871	213	49.77	1	213	1	211	2.0e-65	242	COG2910	Putative NADH-flavin reductase	211
643872872	296	26.1	6	294	2	293	1.0e-34	140	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872873	152	47.89	1	142	1	142	2.0e-41	161	COG3304	Uncharacterized membrane protein YccF, DUF307 family	145
643872876	247	36.1	18	247	29	266	3.0e-47	182	COG1533	DNA repair photolyase	297
643872877	127	20.91	5	114	13	109	5.0e-08	50.3	COG2149	Uncharacterized membrane protein YidH, DUF202 family	120
643872879	436	32.72	1	426	1	414	2.0e-110	393	COG1004	UDP-glucose 6-dehydrogenase	414
643872880	490	17.43	37	444	9	383	7.0e-08	52.6	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
643872886	489	52.85	1	330	2	333	1.0e-124	440	COG0836	Mannose-1-phosphate guanylyltransferase	333
643872887	457	35.34	1	455	4	459	2.0e-99	356	COG1109	Phosphomannomutase	464
643872891	712	47.26	1	381	2	377	3.0e-118	419	COG0116	23S rRNA G2445 N2-methylase RlmL	381
643872892	640	43.81	1	534	1	530	0.0e+00	548	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
643872894	58	68.52	1	54	1	54	6.0e-14	68.9	COG3130	Ribosome modulation factor	55
643872895	185	35.44	26	181	1	147	2.0e-36	144	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
643872896	663	36.11	77	638	71	638	1.0e-111	397	COG1067	Predicted ATP-dependent protease	647
643872898	225	54.46	2	225	3	223	2.0e-65	241	COG3148	Uncharacterized conserved protein YfiP, DTW domain	231
643872900	92	32.26	1	82	4	95	6.0e-09	52.4	COG0633	Ferredoxin	102
643872901	377	35.11	2	373	1	347	6.0e-87	314	COG0208	Ribonucleotide reductase beta subunit, ferritin-like domain	348
643872902	758	36.77	41	752	1	654	0.0e+00	591	COG0209	Ribonucleotide reductase alpha subunit	696
643872903	222	35.19	8	221	6	218	2.0e-37	149	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
643872904	232	59.83	1	231	10	242	1.0e-85	309	COG2227	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase	243
643872905	862	60.33	1	843	1	804	0.0e+00	1079	COG0188	DNA gyrase/topoisomerase IV, subunit A	804
643872907	380	46.24	6	361	2	351	5.0e-114	404	COG0026	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	375
643872908	175	58.08	8	174	2	162	3.0e-56	211	COG0041	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	162
643872910	313	37.96	5	310	19	371	7.0e-55	207	COG3329	Uncharacterized conserved protein	372
643872911	303	26.35	2	295	1	291	8.0e-26	111	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872912	327	34.38	12	322	10	317	1.0e-67	250	COG0042	tRNA-dihydrouridine synthase	323
643872913	206	33.33	3	206	3	232	4.0e-24	104	COG0847	DNA polymerase III, epsilon subunit or related 3'-5' exonuclease	243
643872914	421	42.07	8	409	9	438	2.0e-77	282	COG2233	Xanthine/uracil permease	451
643872915	135	27.86	1	124	1	137	5.0e-15	73.7	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
643872916	213	56.4	1	211	1	211	6.0e-84	303	COG0177	Endonuclease III	211
643872917	247	68.6	24	230	6	212	2.0e-79	289	COG4660	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfE subunit	212
643872918	208	47.96	2	197	1	195	4.0e-55	207	COG4659	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfG subunit	195
643872919	348	52.45	2	348	1	335	2.0e-92	332	COG4658	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfD subunit	338
643872920	704	52.83	13	527	1	529	0.0e+00	545	COG4656	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfC subunit	529
643872921	185	62.5	1	182	1	184	4.0e-64	237	COG2878	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit	198
643872922	193	73.58	1	193	1	193	1.0e-62	232	COG4657	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfA subunit	193
643872923	300	26.3	3	289	6	292	2.0e-08	53.7	COG0697	Permease of the drug/metabolite transporter (DMT) superfamily	292
643872925	171	26.9	6	164	56	222	2.0e-18	85.5	COG1451	Predicted metal-dependent hydrolase	223
643872927	253	33.07	2	253	1	257	1.0e-19	90.1	COG0730	Uncharacterized membrane protein YfcA	258
643872929	543	32.3	1	540	1	576	3.0e-77	283	COG3593	Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains	581
643872930	320	52.79	1	320	1	341	1.0e-105	376	COG0205	6-phosphofructokinase	347
643872931	251	52.38	1	251	1	249	1.0e-72	266	COG0149	Triosephosphate isomerase	251
643872932	251	27.92	16	251	1	222	7.0e-17	81	COG1434	Uncharacterized SAM-binding protein YcdF, DUF218 family	223
643872934	445	51.03	9	445	6	440	3.0e-130	458	COG3006	Chromosome condensin MukBEF complex, kleisin-like MukF subunit	440
643872935	240	59.73	10	234	8	233	1.0e-78	286	COG3095	Chromosome condensin MukBEF, MukE localization factor	238
643872936	1480	49.53	1	1474	1	1468	0.0e+00	1363	COG3096	Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655	1480
643872937	378	36.75	141	255	1	117	1.0e-15	77.7	COG5433	Predicted transposase YbfD/YdcC associated with H repeats	121
643872939	396	61.11	1	396	1	396	0.0e+00	588	COG1448	Aspartate/tyrosine/aromatic aminotransferase	396
643872940	360	34.39	1	331	1	343	2.0e-73	269	COG1744	Basic membrane lipoprotein Med, periplasmic binding protein (PBP1-ABC) superfamily	345
643872941	308	47.02	4	305	5	301	9.0e-73	267	COG1079	ABC-type uncharacterized transport system, permease component	304
643872942	356	43.18	4	352	3	354	7.0e-76	277	COG4603	ABC-type uncharacterized transport system, permease component	356
643872943	506	49.3	8	500	5	501	0.0e+00	590	COG3845	ABC-type uncharacterized transport system, ATPase component	501
643872945	398	23.53	22	391	17	384	8.0e-17	81.8	COG2814	Predicted arabinose efflux permease, MFS family	394
643872946	167	50.9	1	167	4	169	2.0e-41	161	COG2862	Uncharacterized membrane protein YqhA	169
643872947	186	42.29	13	183	2	176	3.0e-33	134	COG0110	Acetyltransferase (isoleucine patch superfamily)	190
643872951	214	34.78	14	185	22	196	1.0e-12	67	COG1994	Zn-dependent protease (includes SpoIVFB)	230
643872953	101	48	1	100	1	100	4.0e-27	112	COG1440	Phosphotransferase system cellobiose-specific component IIB	102
643872954	477	48.12	2	476	1	456	0.0e+00	588	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
643872955	86	43.21	6	86	5	85	2.0e-10	57.9	COG4095	Uncharacterized conserved protein, contains PQ loop repeat	89
643872956	442	35.7	8	428	1	403	3.0e-130	458	COG0137	Argininosuccinate synthase	403
643872957	255	44.66	1	253	2	254	6.0e-76	277	COG1120	ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component	258
643872958	300	22.59	35	294	54	316	5.0e-25	108	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
643872959	630	36.02	322	629	7	328	7.0e-39	155	COG0609	ABC-type Fe3+-siderophore transport system, permease component	334
643872960	725	23.47	3	725	12	750	4.0e-31	130	COG4774	Outer membrane receptor for monomeric catechols	750
643872961	551	56.28	1	549	1	544	0.0e+00	616	COG4615	ABC-type siderophore export system, fused ATPase and permease components	546
643872963	305	25.33	4	294	2	294	1.0e-34	140	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872964	385	64.68	1	385	1	384	0.0e+00	587	COG1979	Alcohol dehydrogenase YqhD, Fe-dependent ADH family	384
643872966	494	34.91	1	487	7	534	8.0e-112	397	COG0659	Sulfate permease or related transporter, MFS superfamily	554
643872967	366	37.75	7	358	6	349	5.0e-92	331	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
643872968	306	25.08	2	290	1	293	4.0e-27	115	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872969	310	34.81	6	290	25	313	1.0e-50	193	COG1171	Threonine dehydratase	347
643872970	298	32.55	5	294	2	288	2.0e-39	155	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872971	547	36.04	46	512	3	461	3.0e-95	342	COG2272	Carboxylesterase type B	491
643872972	297	31.53	4	294	1	288	2.0e-39	156	COG0583	DNA-binding transcriptional regulator, LysR family	297
643872973	328	38.56	1	313	1	315	2.0e-82	299	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
643872974	109	30.85	10	103	5	98	8.0e-14	68.8	COG1359	Quinol monooxygenase YgiN	100
643872976	623	35.7	200	620	30	405	6.0e-83	302	COG4624	Iron only hydrogenase large subunit, C-terminal domain	411
643872977	570	44.53	164	561	11	420	6.0e-117	414	COG1894	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit (chain F)	424
643872978	383	30.68	121	379	9	258	3.0e-37	149	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
643872982	497	33.33	7	479	5	429	2.0e-87	316	COG0579	L-2-hydroxyglutarate oxidase LhgO	429
643872985	374	34.53	60	360	41	338	1.0e-72	266	COG2951	Membrane-bound lytic murein transglycosylase B	343
643872986	814	28.07	56	440	1	380	3.0e-51	197	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
643872987	346	36.84	252	345	29	123	2.0e-13	70.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643872988	327	37.61	1	325	1	315	9.0e-89	320	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
643872991	978	22.22	579	962	20	329	1.0e-27	119	COG2206	HD-GYP domain, c-di-GMP phosphodiesterase class II (or its inactivated variant)	344
643872992	432	20.05	51	414	18	287	5.0e-14	72.5	COG4974	Site-specific recombinase XerD	300
643872993	398	56.31	1	396	1	396	0.0e+00	581	COG1448	Aspartate/tyrosine/aromatic aminotransferase	396
643872994	201	46.53	1	198	1	202	3.0e-54	205	COG1182	FMN-dependent NADH-azoreductase	202
643872996	246	40.4	1	246	3	252	5.0e-56	211	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643872997	193	46.35	1	191	1	182	2.0e-48	185	COG0717	Deoxycytidine triphosphate deaminase	183
643872998	214	54.67	1	214	1	210	2.0e-71	262	COG0572	Uridine kinase	218
643872999	357	43.84	39	311	3	265	4.0e-61	228	COG0489	Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster	265
643873000	675	42.78	2	548	1	558	0.0e+00	675	COG0143	Methionyl-tRNA synthetase	558
643873001	244	27.82	2	243	6	244	1.0e-24	106	COG1651	Protein-disulfide isomerase	244
643873002	381	46.28	3	376	12	382	3.0e-91	328	COG2850	Ribosomal protein L16 Arg81 hydroxylase, contains JmjC domain	383
643873004	461	28.51	1	441	1	442	3.0e-25	110	COG0531	Amino acid transporter	466
643873005	463	57.97	2	434	3	434	0.0e+00	665	COG4303	Ethanolamine ammonia-lyase, large subunit	453
643873006	264	45.99	8	243	64	294	2.0e-65	242	COG4302	Ethanolamine ammonia-lyase, small subunit	294
643873007	329	45.95	1	328	1	321	7.0e-91	327	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
643873008	187	60.53	4	187	18	207	1.0e-51	196	COG1584	Succinate-acetate transporter protein	207
643873009	437	38.97	1	424	3	403	1.0e-111	396	COG1252	NADH dehydrogenase, FAD-containing subunit	405
643873010	183	42.93	1	180	1	189	4.0e-57	213	COG3150	Predicted esterase YcpF, UPF0227 family	191
643873011	334	45.7	1	297	5	300	2.0e-82	299	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
643873012	387	39.21	104	380	5	279	3.0e-81	295	COG0077	Prephenate dehydratase	279
643873014	337	44.3	47	337	3	288	4.0e-89	321	COG0167	Dihydroorotate dehydrogenase	310
643873015	865	38.02	1	858	5	859	0.0e+00	643	COG0308	Aminopeptidase N	859
643873016	215	39.81	2	212	1	211	6.0e-52	197	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
643873017	614	49.83	9	613	3	581	0.0e+00	631	COG0322	Excinuclease UvrABC, nuclease subunit	581
643873018	183	41.9	1	178	11	188	6.0e-26	110	COG0558	Phosphatidylglycerophosphate synthase	192
643873023	135	45.97	10	132	4	127	9.0e-22	95.8	COG2916	DNA-binding protein H-NS	128
643873025	232	47.41	1	232	9	235	3.0e-68	251	COG0284	Orotidine-5'-phosphate decarboxylase	240
643873026	385	45.62	1	384	1	388	4.0e-110	391	COG2956	Lipopolysaccharide biosynthesis regulator YciM, contains six TPR domains and a predicted metal-binding C-terminal domain	389
643873027	94	38.89	4	93	1	90	3.0e-09	53.7	COG3771	Uncharacterized membrane protein YciS, DUF1049 family	97
643873028	93	50.55	1	91	2	91	6.0e-28	115	COG0776	Bacterial nucleoid DNA-binding protein	94
643873029	556	60	1	549	1	541	0.0e+00	616	COG0539	Ribosomal protein S1	541
643873030	230	53.6	6	226	3	221	3.0e-76	278	COG0283	Cytidylate kinase	222
643873031	150	54.05	1	148	1	148	1.0e-46	178	COG2983	Uncharacterized cysteine cluster protein YcgN, CxxCxxCC family	153
643873032	95	40.86	1	93	11	103	5.0e-19	86.2	COG3100	Uncharacterized conserved protein YcgL, UPF0745 family	103
643873033	251	36.44	7	251	2	219	3.0e-44	172	COG0850	Septum formation inhibitor MinC	219
643873034	270	75.93	1	270	1	269	2.0e-125	441	COG2894	Septum formation inhibitor-activating ATPase MinD	272
643873035	99	56.32	1	87	1	85	2.0e-21	94.1	COG0851	Septum formation topological specificity factor MinE	88
643873036	365	35.1	6	363	1	351	3.0e-63	235	COG0349	Ribonuclease D	361
643873037	252	41.96	1	252	1	250	1.0e-63	236	COG0327	Putative GTP cyclohydrolase 1 type 2, NIF3 family	250
643873039	418	44.52	6	413	1	419	3.0e-116	412	COG0285	Folylpolyglutamate synthase/Dihydropteroate synthase	427
643873040	288	63.6	1	279	1	283	1.0e-121	429	COG0777	Acetyl-CoA carboxylase beta subunit	294
643873041	261	56.25	1	256	2	257	3.0e-94	338	COG0101	tRNA U38,U39,U40 pseudouridine synthase TruA	266
643873042	697	19.53	33	696	155	754	4.0e-08	53.9	COG3170	Tfp pilus assembly protein FimV	755
643873043	320	23.91	2	315	1	334	2.0e-27	116	COG0136	Aspartate-semialdehyde dehydrogenase	334
643873044	373	33.23	1	276	2	304	3.0e-45	176	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
643873045	404	46.84	1	402	2	411	6.0e-118	417	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
643873046	636	37.75	1	249	2	247	4.0e-74	273	COG4121	tRNA U34 5-methylaminomethyl-2-thiouridine-forming methyltransferase MnmC	252
643873047	315	27.81	1	315	4	322	8.0e-53	200	COG0598	Mg2+ and Co2+ transporter CorA	322
643873049	468	66.38	5	465	4	462	0.0e+00	747	COG0114	Fumarate hydratase class II	462
643873050	257	76.8	4	253	5	253	2.0e-117	415	COG4598	ABC-type histidine transport system, ATPase component	256
643873051	238	54.39	7	234	1	228	2.0e-73	268	COG4160	ABC-type arginine/histidine transport system, permease component	228
643873052	228	53.71	1	226	2	230	3.0e-69	254	COG4215	ABC-type arginine transport system, permease component	230
643873053	259	31.99	1	258	1	269	4.0e-40	158	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
643873054	183	21.43	32	156	1	123	1.0e-06	46.1	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
643873055	63	58	8	57	3	52	2.0e-09	54.2	COG3036	Stalled ribosome alternative rescue factor ArfA	66
643873060	543	18.43	6	222	2	186	4.0e-12	66.6	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
643873063	692	26.29	237	673	28	431	3.0e-53	203	COG1061	Superfamily II DNA or RNA helicase	442
643873070	86	28	1	75	2	69	6.0e-07	46	COG3655	DNA-binding transcriptional regulator, XRE family	73
643873072	393	19.62	83	393	3	309	4.0e-08	52.7	COG0582	Integrase	309
643873075	413	28.57	262	391	4	136	3.0e-15	76.6	COG4639	Predicted kinase	168
643873080	513	29.03	31	275	1	246	8.0e-33	135	COG4584	Transposase	278
643873081	251	34.16	1	241	6	248	2.0e-45	175	COG1484	DNA replication protein DnaC	254
643873084	650	26.12	1	508	1	495	4.0e-50	193	COG3593	Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains	581
643873089	207	54.31	8	203	14	202	2.0e-65	242	COG0378	Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase	202
643873090	231	34.5	8	231	1	229	2.0e-40	159	COG0830	Urease accessory protein UreF	229
643873091	184	40.51	9	158	15	172	2.0e-11	62.3	COG2370	Hydrogenase/urease accessory protein HupE	201
643873092	188	41.51	1	157	1	155	3.0e-27	115	COG2371	Urease accessory protein UreE	155
643873093	567	77.11	1	567	1	568	0.0e+00	1041	COG0804	Urease alpha subunit	568
643873094	119	65.05	1	103	1	103	1.0e-43	168	COG0832	Urease beta subunit	106
643873095	100	78.79	1	99	1	99	2.0e-45	173	COG0831	Urease gamma subunit	100
643873096	280	40.15	10	278	1	269	6.0e-62	230	COG0829	Urease accessory protein UreH	269
643873097	231	48.51	1	231	3	237	3.0e-83	301	COG0410	ABC-type branched-chain amino acid transport system, ATPase component	237
643873098	279	65.29	35	276	5	246	3.0e-105	374	COG4674	ABC-type uncharacterized transport system, ATPase component	249
643873099	360	35.4	24	357	7	311	1.0e-46	180	COG4177	ABC-type branched-chain amino acid transport system, permease component	314
643873100	533	41.44	241	530	7	296	3.0e-66	246	COG0559	Branched-chain amino acid ABC-type transport system, permease component	297
643873101	422	33.06	18	378	2	361	1.0e-69	257	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	366
643873102	1131	28.83	572	903	13	335	1.0e-45	179	COG0642	Signal transduction histidine kinase	336
643873104	158	32.24	1	152	4	154	3.0e-24	104	COG1522	DNA-binding transcriptional regulator, Lrp family	154
643873105	266	64.84	10	265	1	256	4.0e-114	404	COG4598	ABC-type histidine transport system, ATPase component	256
643873106	256	31.66	3	256	15	270	1.0e-39	156	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
643873107	239	47.79	15	237	4	229	3.0e-62	232	COG4215	ABC-type arginine transport system, permease component	230
643873108	229	41.92	1	228	1	225	1.0e-60	226	COG4160	ABC-type arginine/histidine transport system, permease component	228
643873109	403	39.39	9	402	6	392	2.0e-96	346	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
643873111	312	23.49	159	304	9	154	1.0e-11	64.6	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
643873112	371	38.78	57	350	6	294	1.0e-70	260	COG1533	DNA repair photolyase	297
643873113	300	33.33	3	293	2	292	5.0e-39	155	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873114	208	45.96	1	193	2	199	3.0e-43	168	COG2085	Predicted dinucleotide-binding enzyme	211
643873115	319	55.84	1	315	3	313	1.0e-114	406	COG0435	Glutathionyl-hydroquinone reductase	324
643873116	135	38.64	1	130	6	135	1.0e-08	52.3	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
643873117	303	33.44	3	299	2	297	1.0e-39	157	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873119	306	31.1	9	302	2	293	1.0e-42	167	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873120	66	44.26	1	60	1	61	4.0e-13	66.1	COG1942	Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family	69
643873121	97	36.59	8	89	7	88	6.0e-14	69.2	COG1359	Quinol monooxygenase YgiN	100
643873122	543	37.42	53	515	5	465	1.0e-99	357	COG2272	Carboxylesterase type B	491
643873123	329	22.05	1	308	1	314	2.0e-28	120	COG0451	Nucleoside-diphosphate-sugar epimerase	314
643873124	337	24.77	15	333	13	340	6.0e-36	145	COG2706	6-phosphogluconolactonase, cycloisomerase 2 family	346
643873125	257	36.51	1	248	1	252	1.0e-48	186	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643873126	325	26.52	1	313	4	325	5.0e-42	165	COG0673	Predicted dehydrogenase	342
643873127	150	42	1	150	6	154	1.0e-31	129	COG1522	DNA-binding transcriptional regulator, Lrp family	154
643873128	204	30.77	1	202	1	207	7.0e-16	77.6	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
643873130	274	29.89	1	266	1	269	6.0e-53	201	COG0157	Nicotinate-nucleotide pyrophosphorylase	280
643873131	286	34.41	6	280	2	256	8.0e-48	184	COG1237	Metal-dependent hydrolase, beta-lactamase superfamily II	259
643873132	147	26.5	27	138	24	139	2.0e-10	58.1	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
643873133	179	27.27	1	113	1	119	1.0e-08	53	COG1433	Predicted Fe-Mo cluster-binding protein, NifX family	121
643873134	93	52.87	1	87	1	87	1.0e-27	114	COG1342	Predicted DNA-binding protein, UPF0251 family	99
643873135	351	36.42	6	348	5	336	4.0e-67	248	COG2038	NaMN:DMB phosphoribosyltransferase	347
643873136	246	42.28	1	246	2	240	7.0e-39	154	COG0368	Cobalamin synthase	246
643873137	182	48.35	1	182	2	175	5.0e-56	210	COG2087	Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase	175
643873138	518	52.54	3	510	2	486	0.0e+00	591	COG1492	Cobyric acid synthase	486
643873139	274	40.43	1	234	2	235	1.0e-63	237	COG1122	Energy-coupling factor transporter ATP-binding protein EcfA2	235
643873140	225	28.84	10	222	10	216	1.0e-14	73.5	COG0619	Energy-coupling factor transporter transmembrane protein EcfT	252
643873141	94	50	1	87	2	91	7.0e-29	118	COG1930	ABC-type cobalt transport system, periplasmic component	97
643873142	239	45.19	25	232	1	198	1.0e-37	150	COG0310	ABC-type Co2+ transport system, permease component	204
643873143	241	41.63	3	233	2	231	2.0e-57	215	COG2243	Precorrin-2 methylase	234
643873144	263	52.65	1	263	1	264	1.0e-100	359	COG4822	Cobalamin biosynthesis protein CbiK, Co2+ chelatase	265
643873145	265	37.16	1	261	1	257	4.0e-64	237	COG2099	Precorrin-6x reductase	257
643873146	241	57.85	1	240	4	244	7.0e-96	343	COG1010	Precorrin-3B methylase	249
643873147	358	27.99	14	356	1	298	5.0e-40	158	COG2073	Cobalamin biosynthesis protein CbiG	298
643873148	257	58.47	10	256	5	252	8.0e-100	356	COG2875	Precorrin-4 methylase	254
643873149	192	44.09	1	184	4	186	2.0e-48	185	COG2242	Precorrin-6B methylase 2	187
643873150	201	33.17	1	200	1	208	2.0e-42	165	COG2241	Precorrin-6B methylase 1	210
643873151	378	48.62	10	370	3	364	3.0e-113	402	COG1903	Cobalamin biosynthesis protein CbiD	367
643873152	214	50.7	2	213	3	209	3.0e-60	225	COG2082	Precorrin isomerase	210
643873153	319	45.45	1	318	4	319	4.0e-84	304	COG1270	Cobalamin biosynthesis protein CobD/CbiB	320
643873154	457	52.97	2	454	1	451	0.0e+00	576	COG1797	Cobyrinic acid a,c-diamide synthase	451
643873155	299	47.34	1	169	1	169	3.0e-63	235	COG4936	Ligand-binding sensor domain	169
643873156	277	44.31	4	255	3	241	1.0e-50	193	COG0580	Glycerol uptake facilitator and related aquaporins (Major Intrinsic Protein Family)	241
643873158	268	45.92	41	264	1	219	1.0e-62	232	COG4816	Ethanolamine utilization protein EutL, ethanolamine utilization microcompartment shell protein	219
643873159	554	82.1	1	553	1	553	0.0e+00	975	COG4909	Propanediol dehydratase, large subunit	554
643873161	172	67.44	1	172	1	170	7.0e-60	223	COG4910	Propanediol dehydratase, small subunit	170
643873165	168	29.27	1	164	1	144	5.0e-19	87.3	COG4577	Carboxysome shell and ethanolamine utilization microcompartment protein CcmL/EutN	150
643873166	210	57.62	2	209	1	209	9.0e-74	269	COG4869	Propanediol utilization protein	210
643873168	95	50	1	90	1	86	1.0e-24	104	COG4576	Carboxysome shell and ethanolamine utilization microcompartment protein CcmK/EutM	89
643873169	347	48.62	1	181	5	180	5.0e-54	205	COG2096	Cob(I)alamin adenosyltransferase	184
643873170	467	22.61	32	445	31	448	6.0e-44	172	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
643873171	371	42.27	1	371	1	377	3.0e-101	361	COG1454	Alcohol dehydrogenase, class IV	377
643873172	459	30.25	10	446	110	520	2.0e-84	306	COG4656	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfC subunit	529
643873173	182	33.97	1	154	1	150	3.0e-21	95	COG4577	Carboxysome shell and ethanolamine utilization microcompartment protein CcmL/EutN	150
643873174	117	65.22	3	117	7	121	2.0e-44	171	COG4810	Ethanolamine utilization protein EutS, ethanolamine utilization microcompartment shell protein	121
643873175	143	48.25	2	143	1	142	8.0e-41	159	COG4917	Ethanolamine utilization protein EutP, contains a P-loop NTPase domain	148
643873176	392	59.44	4	392	2	392	0.0e+00	563	COG0282	Acetate kinase	396
643873177	260	56.85	1	241	2	240	1.0e-81	296	COG0007	Uroporphyrinogen-III methylase (siroheme synthase)	244
643873178	359	32.49	6	355	7	351	2.0e-72	266	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
643873179	286	38.35	2	277	14	291	9.0e-72	263	COG4542	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic...	293
643873180	319	64.95	2	312	4	313	5.0e-124	437	COG3940	Beta-xylosidase, GH43 family	324
643873181	332	37.72	6	332	1	329	4.0e-63	235	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643873182	437	23.99	55	434	47	430	3.0e-35	142	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
643873183	301	37.45	30	300	8	281	3.0e-56	212	COG0395	ABC-type glycerol-3-phosphate transport system, permease component	281
643873184	293	40.62	6	291	5	292	3.0e-51	195	COG1175	ABC-type sugar transport system, permease component	295
643873185	365	50.99	3	357	2	338	4.0e-116	411	COG3839	ABC-type sugar transport system, ATPase component	338
643873186	503	51.2	1	502	2	499	0.0e+00	643	COG3534	Alpha-L-arabinofuranosidase	501
643873187	837	28.12	55	426	1	361	1.0e-50	195	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
643873188	338	32.76	223	337	10	120	2.0e-16	80.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643873190	173	34.52	1	164	1	165	9.0e-23	99.7	COG1495	Disulfide bond formation protein DsbB	170
643873191	333	42.46	18	333	12	328	8.0e-67	247	COG0714	MoxR-like ATPase	329
643873197	106	45.74	2	95	1	94	2.0e-28	117	COG0776	Bacterial nucleoid DNA-binding protein	94
643873198	796	45.29	143	795	1	650	0.0e+00	686	COG0072	Phenylalanyl-tRNA synthetase beta subunit	650
643873199	327	58.26	1	325	3	335	0.0e+00	462	COG0016	Phenylalanyl-tRNA synthetase alpha subunit	335
643873200	118	78.81	1	118	1	118	8.0e-41	158	COG0292	Ribosomal protein L20	118
643873201	65	69.23	1	65	1	65	4.0e-11	59.5	COG0291	Ribosomal protein L35	65
643873202	179	68.07	14	179	10	175	3.0e-61	227	COG0290	Translation initiation factor IF-3	176
643873203	642	53.73	34	635	1	583	0.0e+00	798	COG0441	Threonyl-tRNA synthetase	589
643873204	95	51.61	2	94	1	92	4.0e-22	96.5	COG1825	Ribosomal protein L25 (general stress protein Ctc)	93
643873205	125	47.46	1	118	1	118	3.0e-29	120	COG0818	Diacylglycerol kinase	123
643873206	262	35.89	1	247	3	245	2.0e-43	169	COG4138	ABC-type cobalamin transport system, ATPase component	248
643873207	338	42.81	8	334	8	325	3.0e-62	232	COG4139	ABC-type cobalamin transport system, permease component	326
643873208	298	52.7	4	297	1	289	7.0e-95	340	COG0040	ATP phosphoribosyltransferase	290
643873209	433	54.21	6	428	1	425	0.0e+00	536	COG0141	Histidinol dehydrogenase	425
643873210	358	38.03	15	358	4	352	6.0e-83	301	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
643873211	357	64.58	169	357	4	195	1.0e-80	293	COG0131	Imidazoleglycerol phosphate dehydratase HisB	195
643873212	200	54.63	1	200	2	202	1.0e-75	276	COG0118	Imidazoleglycerol phosphate synthase glutamine amidotransferase subunit HisH	204
643873213	245	55.28	1	245	3	241	6.0e-74	270	COG0106	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase	241
643873214	257	54.26	1	256	1	254	6.0e-105	373	COG0107	Imidazole glycerol phosphate synthase subunit HisF	256
643873215	206	53	11	109	10	108	1.0e-35	143	COG0139	Phosphoribosyl-AMP cyclohydrolase	111
643873216	414	27.42	1	410	17	431	5.0e-54	205	COG3706	Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain	435
643873217	167	36.59	24	145	4	126	3.0e-15	74.6	COG1846	DNA-binding transcriptional regulator, MarR family	126
643873218	483	32.95	47	476	25	454	5.0e-57	215	COG1538	Outer membrane protein TolC	457
643873219	396	43.15	13	347	8	343	4.0e-85	308	COG1566	Multidrug resistance efflux pump	352
643873221	143	36.45	1	106	1	107	1.0e-17	82.5	COG0789	DNA-binding transcriptional regulator, MerR family	124
643873222	734	40.75	105	733	70	710	0.0e+00	644	COG2217	Cation transport ATPase	713
643873223	311	37.18	4	311	1	311	8.0e-71	260	COG0039	Malate/lactate dehydrogenase	313
643873227	277	31.3	50	274	8	236	4.0e-35	142	COG0412	Dienelactone hydrolase	236
643873228	144	46.38	1	138	2	138	2.0e-41	161	COG0314	Molybdopterin synthase catalytic subunit	149
643873229	80	43.37	1	80	2	84	2.0e-16	77.7	COG1977	Molybdopterin converting factor, small subunit	84
643873230	159	63.23	5	159	3	156	4.0e-59	220	COG0315	Molybdenum cofactor biosynthesis enzyme	157
643873231	170	53.29	6	170	3	168	9.0e-55	206	COG0521	Molybdopterin biosynthesis enzyme MoaB	169
643873232	194	31.77	1	180	2	187	4.0e-25	108	COG0746	Molybdopterin-guanine dinucleotide biosynthesis protein A	192
643873233	336	45.06	14	336	2	322	7.0e-102	364	COG2896	Molybdenum cofactor biosynthesis enzyme MoaA	322
643873234	267	48.83	2	254	1	254	7.0e-68	250	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
643873235	406	44.53	7	404	5	404	8.0e-119	420	COG0303	Molybdopterin biosynthesis enzyme	404
643873236	109	34.58	1	106	3	103	5.0e-14	69.6	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	106
643873237	839	45.24	1	806	1	793	0.0e+00	918	COG1251	NAD(P)H-nitrite reductase, large subunit	793
643873238	575	27	1	243	2	260	2.0e-36	147	COG0631	Serine/threonine protein phosphatase PrpC	262
643873239	489	23.75	13	459	10	392	6.0e-40	158	COG2223	Nitrate/nitrite transporter NarK	417
643873240	305	28.43	4	297	1	292	8.0e-38	151	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873242	371	40.11	1	366	3	359	1.0e-84	307	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
643873243	276	50.19	3	261	1	248	3.0e-88	318	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
643873244	312	28.38	1	303	1	250	7.0e-39	154	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	258
643873245	454	26.91	1	374	1	335	7.0e-39	155	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	335
643873247	253	52.07	1	242	2	241	7.0e-75	274	COG0007	Uroporphyrinogen-III methylase (siroheme synthase)	244
643873248	872	32.04	4	698	41	765	1.0e-129	457	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
643873249	197	28.57	1	190	7	202	9.0e-44	170	COG1573	Uracil-DNA glycosylase	202
643873252	315	35.76	39	315	42	322	6.0e-65	241	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
643873253	324	45.54	1	320	1	323	7.0e-95	340	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
643873254	912	39.91	15	899	30	909	0.0e+00	760	COG0474	Magnesium-transporting ATPase (P-type)	917
643873255	398	21.21	3	395	1	388	4.0e-13	69.5	COG2814	Predicted arabinose efflux permease, MFS family	394
643873256	296	22.18	1	265	1	247	2.0e-17	83.2	COG0613	Predicted metal-dependent phosphoesterase TrpH, contains PHP domain	258
643873257	260	40.24	10	259	2	252	1.0e-54	206	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643873259	335	39.88	1	323	1	316	6.0e-81	294	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
643873261	301	26.78	6	296	4	292	1.0e-36	146	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873262	382	39.69	1	381	1	383	5.0e-110	391	COG1979	Alcohol dehydrogenase YqhD, Fe-dependent ADH family	384
643873264	332	37.54	13	321	1	307	4.0e-48	185	COG0524	Sugar or nucleoside kinase, ribokinase family	311
643873265	426	22.01	10	426	25	448	3.0e-33	136	COG2271	Sugar phosphate permease	448
643873266	325	44	1	320	1	323	7.0e-87	314	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
643873267	602	37.17	6	599	3	574	0.0e+00	559	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
643873268	215	52.15	3	211	2	210	7.0e-64	237	COG0800	2-keto-3-deoxy-6-phosphogluconate aldolase	211
643873271	343	36.14	12	341	1	329	1.0e-68	254	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643873272	139	41.18	1	136	1	134	2.0e-29	121	COG0848	Biopolymer transport protein ExbD	137
643873273	253	38.24	28	231	14	216	9.0e-34	137	COG0811	Biopolymer transport protein ExbB/TolQ	216
643873274	233	26.92	22	232	11	244	4.0e-13	68.6	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
643873277	362	42.24	8	352	2	348	2.0e-61	229	COG3180	Uncharacterized membrane protein AbrB, regulator of aidB expression	352
643873278	429	21.24	1	428	6	417	2.0e-40	160	COG0443	Molecular chaperone DnaK (HSP70)	579
643873280	236	26.51	1	228	5	237	1.0e-19	90.7	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643873281	677	25.96	80	546	1	397	3.0e-45	176	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
643873285	92	27.47	1	90	3	93	4.0e-11	59.7	COG3668	Plasmid stabilization system protein ParE	98
643873287	212	24.88	1	212	2	206	7.0e-21	94.3	COG0778	Nitroreductase	207
643873290	104	34	1	100	6	104	3.0e-20	90	COG2944	DNA-binding transcriptional regulator YiaG, XRE-type HTH domain	104
643873291	143	50.69	1	143	13	155	9.0e-30	122	COG1238	Uncharacterized membrane protein YqaA, SNARE-associated domain	161
643873293	154	37.68	1	136	1	138	1.0e-26	112	COG1959	DNA-binding transcriptional regulator, IscR family	150
643873294	247	26.39	1	247	2	266	4.0e-34	138	COG1018	Ferredoxin-NADP reductase	266
643873296	471	43.99	2	391	4	386	2.0e-121	430	COG0426	Flavorubredoxin	388
643873297	214	25.13	44	206	56	237	5.0e-16	78	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
643873298	315	40.82	1	315	6	318	8.0e-77	280	COG2390	DNA-binding transcriptional regulator LsrR, DeoR family	321
643873299	363	59.61	1	203	1	202	8.0e-81	294	COG0108	3,4-dihydroxy-2-butanone 4-phosphate synthase	203
643873300	148	41.1	1	146	1	141	3.0e-36	144	COG4154	L-fucose mutarotase/ribose pyranase, RbsD/FucU family	144
643873301	472	37.66	7	471	6	467	4.0e-110	392	COG2407	L-fucose isomerase or related protein	470
643873302	493	47.39	1	493	2	498	0.0e+00	581	COG0554	Glycerol kinase	499
643873303	317	42.31	1	311	3	312	3.0e-93	335	COG3958	Transketolase, C-terminal subunit	312
643873304	276	55.42	6	244	5	243	1.0e-90	326	COG3959	Transketolase, N-terminal subunit	243
643873305	360	40.3	19	347	1	313	2.0e-56	213	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
643873306	505	45.76	1	504	1	500	0.0e+00	545	COG1129	ABC-type sugar transport system, ATPase component	500
643873307	202	31.55	19	199	15	201	1.0e-31	130	COG5618	Predicted periplasmic lipoprotein	206
643873308	312	35.83	10	312	18	322	3.0e-47	182	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
643873309	317	38.34	5	313	1	238	3.0e-64	239	COG0176	Transaldolase	239
643873310	666	62.75	6	666	7	663	0.0e+00	1053	COG0021	Transketolase	663
643873311	514	48.57	2	514	31	546	0.0e+00	506	COG3604	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains	550
643873312	221	50.69	1	217	1	217	1.0e-72	266	COG2846	Iron-sulfur cluster repair protein YtfE, RIC family, contains ScdAN and hemerythrin domains	221
643873313	398	59.73	1	149	2	150	1.0e-60	227	COG1017	Hemoglobin-like flavoprotein	150
643873314	392	39.43	214	388	10	181	4.0e-42	165	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643873315	886	40.78	10	882	33	914	0.0e+00	757	COG0474	Magnesium-transporting ATPase (P-type)	917
643873316	145	23.08	1	126	2	143	4.0e-07	47.3	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
643873317	318	36.15	8	300	1	290	5.0e-37	148	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873318	471	59.69	1	447	1	449	0.0e+00	593	COG0439	Biotin carboxylase	449
643873319	603	66.88	1	461	2	462	0.0e+00	727	COG5016	Pyruvate/oxaloacetate carboxyltransferase	472
643873320	542	40.04	1	542	4	548	0.0e+00	477	COG2194	Phosphoethanolamine transferase for periplasmic glucans (OPG), alkaline phosphatase superfamily	555
643873321	214	19.71	2	207	7	193	3.0e-11	61.8	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	201
643873323	388	31.4	121	373	8	252	1.0e-40	160	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
643873324	388	45.48	7	381	4	379	3.0e-127	448	COG1168	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities	388
643873326	401	34.3	17	394	11	389	6.0e-64	238	COG2814	Predicted arabinose efflux permease, MFS family	394
643873327	412	30	26	411	19	416	3.0e-55	209	COG1914	Mn2+ and Fe2+ transporters of the NRAMP family	416
643873328	251	60.16	1	251	1	251	7.0e-100	356	COG1540	Lactam utilization protein B (function unknown)	252
643873329	315	49.51	7	307	1	306	7.0e-96	344	COG1984	Allophanate hydrolase subunit 2	314
643873330	230	50.72	22	227	5	213	7.0e-73	267	COG2049	Allophanate hydrolase subunit 1	223
643873331	170	42.17	5	170	34	199	8.0e-45	172	COG5631	Predicted transcription regulator, contains HTH domain, MarR family	199
643873332	273	23.83	10	255	14	262	2.0e-20	93.5	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
643873333	520	54.25	260	505	1	240	4.0e-94	339	COG1126	ABC-type polar amino acid transport system, ATPase component	240
643873334	222	26.32	16	222	19	226	8.0e-22	97.5	COG1802	DNA-binding transcriptional regulator, GntR family	230
643873335	290	34.81	1	266	8	263	4.0e-59	221	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	264
643873342	254	42.75	1	254	1	252	2.0e-62	232	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643873343	118	30.51	1	116	5	122	1.0e-14	72.3	COG4578	DNA-binding transcriptional regulator of glucitol operon	128
643873344	258	34.23	1	256	4	251	1.0e-37	150	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643873345	121	50.83	1	120	1	120	5.0e-34	136	COG3731	Phosphotransferase system sorbitol-specific component IIA	123
643873346	327	67.99	1	327	1	328	0.0e+00	466	COG3732	Phosphotransferase system sorbitol-specific component IIBC	328
643873347	184	66.86	1	175	2	176	4.0e-70	257	COG3730	Phosphotransferase system sorbitol-specific component IIC	176
643873351	60	43.33	1	60	7	65	8.0e-06	42.2	COG1724	Predicted RNA binding protein YcfA, dsRBD-like fold, HicA-like mRNA interferase family	66
643873354	299	40.24	1	169	1	169	2.0e-51	195	COG4936	Ligand-binding sensor domain	169
643873356	321	56.93	5	205	1	202	9.0e-63	233	COG0794	D-arabinose 5-phosphate isomerase GutQ	202
643873357	329	29.07	1	296	3	311	4.0e-52	198	COG0673	Predicted dehydrogenase	342
643873358	273	46.07	1	273	2	272	1.0e-78	286	COG1806	Regulator of PEP synthase PpsR, kinase-PPPase family (combines ADP:protein kinase and phosphorylase activities)	273
643873359	336	57.4	4	334	1	325	4.0e-130	457	COG0158	Fructose-1,6-bisphosphatase	326
643873360	787	50.77	1	779	2	732	0.0e+00	761	COG0574	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase	740
643873361	368	40	1	360	1	359	8.0e-91	327	COG0371	Glycerol dehydrogenase or related enzyme, iron-containing ADH family	360
643873362	227	33.04	1	219	8	236	1.0e-45	176	COG0176	Transaldolase	239
643873363	280	44.18	10	255	7	239	1.0e-45	176	COG0580	Glycerol uptake facilitator and related aquaporins (Major Intrinsic Protein Family)	241
643873365	400	54.41	4	398	1	394	0.0e+00	562	COG0282	Acetate kinase	396
643873367	115	44.21	7	101	4	98	4.0e-27	113	COG1445	Phosphotransferase system fructose-specific component IIB	122
643873368	349	43.33	17	342	6	333	5.0e-66	245	COG1299	Phosphotransferase system, fructose-specific IIC component	343
643873369	295	32.23	1	295	6	305	1.0e-46	180	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
643873370	287	30	14	281	16	253	4.0e-47	181	COG1180	Pyruvate-formate lyase-activating enzyme	260
643873371	766	32.7	2	766	2	755	0.0e+00	668	COG1882	Pyruvate-formate lyase	755
643873372	106	55.34	1	103	1	103	2.0e-28	117	COG1445	Phosphotransferase system fructose-specific component IIB	122
643873373	354	52.06	10	340	1	340	4.0e-77	281	COG1299	Phosphotransferase system, fructose-specific IIC component	343
643873374	477	52.49	10	341	1	341	9.0e-86	311	COG1299	Phosphotransferase system, fructose-specific IIC component	343
643873375	255	25.99	15	217	8	225	3.0e-14	72.3	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	299
643873376	835	35.81	691	834	5	151	3.0e-23	104	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
643873376	835	46.34	118	686	1	573	0.0e+00	667	COG1080	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)	574
643873379	394	20.71	71	375	1	297	1.0e-09	57.7	COG0582	Integrase	309
643873388	284	59.29	4	283	1	280	3.0e-111	394	COG0190	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	283
643873389	358	25.6	27	357	1	333	8.0e-32	131	COG0642	Signal transduction histidine kinase	336
643873390	220	43.86	1	218	1	228	3.0e-56	211	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
643873391	463	60.09	1	462	1	464	0.0e+00	701	COG0215	Cysteinyl-tRNA synthetase	464
643873392	165	51.81	2	165	1	158	2.0e-50	191	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
643873393	246	48.75	4	240	1	235	1.0e-64	239	COG2908	UDP-2,3-diacylglucosamine pyrophosphatase LpxH	237
643873398	518	51.94	1	516	1	511	0.0e+00	579	COG3283	Transcriptional regulator of aromatic amino acids metabolism	511
643873400	382	37.11	1	381	1	383	5.0e-110	391	COG1979	Alcohol dehydrogenase YqhD, Fe-dependent ADH family	384
643873401	166	36.11	21	164	29	165	9.0e-24	103	COG4925	Uncharacterized protein	166
643873402	368	27.52	51	368	2	299	1.0e-36	147	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
643873403	316	40.32	184	307	1	124	2.0e-21	96.9	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643873406	342	18.15	4	295	83	359	4.0e-24	105	COG3550	Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module	392
643873408	102	29.63	4	84	14	94	3.0e-06	43.5	COG5569	Periplasmic Cu and Ag efflux protein CusF	108
643873409	286	33.9	3	286	1	292	4.0e-38	151	COG0524	Sugar or nucleoside kinase, ribokinase family	311
643873410	285	38.43	4	284	1	281	3.0e-57	215	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
643873411	323	48.06	17	323	4	312	2.0e-57	216	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
643873412	504	47.78	1	493	4	498	0.0e+00	575	COG1129	ABC-type sugar transport system, ATPase component	500
643873413	346	33.56	54	338	34	322	1.0e-46	181	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
643873414	327	23.79	30	322	77	379	1.0e-17	84.3	COG4952	L-rhamnose isomerase	430
643873415	270	28.71	165	265	25	125	1.0e-16	80.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643873416	466	37.11	18	463	6	453	1.0e-101	364	COG2211	Na+/melibiose symporter or related transporter	467
643873417	655	39.97	3	655	2	588	0.0e+00	627	COG3533	Uncharacterized conserved protein, DUF1680 family	589
643873419	268	33.46	1	252	2	260	1.0e-41	163	COG0300	Short-chain dehydrogenase	265
643873421	479	23.9	1	477	16	610	1.0e-64	240	COG1022	Long-chain acyl-CoA synthetase (AMP-forming)	613
643873423	451	43.27	272	441	4	173	4.0e-41	162	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643873424	413	23.18	43	400	43	403	4.0e-34	139	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
643873425	413	35.5	12	410	3	383	1.0e-108	387	COG0075	Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG	383
643873426	272	28.36	10	272	6	255	4.0e-10	58.9	COG0730	Uncharacterized membrane protein YfcA	258
643873427	539	32.22	5	526	13	537	1.0e-102	367	COG0405	Gamma-glutamyltranspeptidase	539
643873428	400	27.76	20	396	69	472	8.0e-58	217	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
643873429	282	21.79	4	275	3	281	5.0e-31	128	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
643873430	230	31.07	6	209	15	219	5.0e-28	117	COG1802	DNA-binding transcriptional regulator, GntR family	230
643873431	347	42.37	3	345	1	350	7.0e-101	360	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
643873432	429	20.77	6	369	2	326	3.0e-22	100	COG0687	Spermidine/putrescine-binding periplasmic protein	363
643873433	287	37.22	17	279	14	276	1.0e-47	183	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
643873434	278	36.94	8	273	5	267	7.0e-38	151	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
643873435	230	39.13	2	223	1	230	2.0e-45	175	COG4126	Asp/Glu/hydantoin racemase	230
643873436	307	28.24	4	298	3	267	9.0e-32	130	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/CDA1 family	267
643873439	250	49.79	1	238	3	243	7.0e-52	197	COG0805	Sec-independent protein secretion pathway component TatC	255
643873440	303	29.41	6	296	6	305	2.0e-37	150	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
643873441	227	45.1	1	203	4	204	3.0e-68	251	COG0036	Pentose-5-phosphate-3-epimerase	220
643873442	326	40.51	17	326	2	311	1.0e-57	216	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
643873443	509	44.2	1	508	4	500	0.0e+00	600	COG1129	ABC-type sugar transport system, ATPase component	500
643873444	310	34.94	3	310	10	314	5.0e-44	171	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
643873445	292	34.32	13	283	7	277	5.0e-56	211	COG1737	DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains	281
643873446	530	35.12	1	433	1	390	1.0e-69	258	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
643873448	219	50.46	1	216	3	215	3.0e-69	255	COG0036	Pentose-5-phosphate-3-epimerase	220
643873449	155	60.54	1	145	1	147	3.0e-49	187	COG0698	Ribose 5-phosphate isomerase RpiB	151
643873451	259	26.12	1	257	2	269	6.0e-30	124	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
643873452	222	47.85	13	220	14	222	3.0e-50	191	COG0765	ABC-type amino acid transport system, permease component	222
643873453	218	50.93	2	216	7	222	2.0e-55	208	COG0765	ABC-type amino acid transport system, permease component	222
643873454	242	59.75	2	242	1	240	6.0e-104	370	COG1126	ABC-type polar amino acid transport system, ATPase component	240
643873455	793	44.71	91	790	37	709	0.0e+00	704	COG2217	Cation transport ATPase	713
643873456	489	33.64	59	489	24	449	2.0e-79	290	COG2132	Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA)	451
643873457	317	30.9	7	302	3	294	1.0e-32	133	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873458	99	43.48	6	97	5	96	2.0e-21	94.2	COG5470	Uncharacterized conserved protein, DUF1330 family	96
643873459	179	25.27	1	173	1	185	3.0e-29	121	COG2249	Putative NADPH-quinone reductase (modulator of drug activity B)	189
643873460	297	29.59	5	294	2	288	4.0e-35	142	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873461	336	40.56	1	318	1	313	6.0e-80	291	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
643873462	265	28.09	175	262	33	120	6.0e-09	55	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	124
643873463	387	21.11	1	377	6	381	4.0e-23	102	COG2814	Predicted arabinose efflux permease, MFS family	394
643873464	297	26.96	5	293	2	287	1.0e-38	153	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873465	544	34.11	35	427	30	457	8.0e-83	301	COG0493	NADPH-dependent glutamate synthase beta chain or related oxidoreductase	457
643873466	1196	36.88	12	393	3	360	8.0e-92	332	COG0674	Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit	365
643873468	762	41.76	437	617	1	180	4.0e-44	173	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643873470	557	36.35	9	525	4	515	1.0e-104	374	COG0661	Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family	517
643873471	347	39.14	12	334	1	315	3.0e-78	285	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
643873472	178	43.7	1	118	1	119	2.0e-26	112	COG1733	DNA-binding transcriptional regulator, HxlR family	120
643873473	425	51.3	3	423	2	412	3.0e-124	438	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
643873474	397	49.74	5	395	1	391	3.0e-125	442	COG1092	23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI	393
643873475	343	43.34	22	342	25	334	7.0e-73	267	COG2038	NaMN:DMB phosphoribosyltransferase	347
643873476	209	33.17	9	200	4	197	3.0e-29	121	COG0406	Broad specificity phosphatase PhoE	208
643873477	201	54.08	8	201	3	198	1.0e-71	262	COG2109	ATP:corrinoid adenosyltransferase	198
643873478	214	34.29	1	203	11	220	1.0e-34	139	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
643873479	307	25.91	5	303	6	295	2.0e-27	117	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873480	453	28.76	1	449	2	436	3.0e-62	232	COG1486	Alpha-galactosidase/6-phospho-beta-glucosidase, family 4 of glycosyl hydrolase	442
643873481	274	34.94	6	273	5	248	9.0e-53	200	COG2853	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, lipoprotein component MlaA	250
643873482	143	58.96	3	136	2	135	4.0e-54	203	COG0105	Nucleoside diphosphate kinase	135
643873483	431	36.83	38	428	80	481	3.0e-97	349	COG0260	Leucyl aminopeptidase	485
643873484	112	44.34	1	104	1	102	6.0e-19	85.9	COG0633	Ferredoxin	102
643873485	616	45.12	21	601	7	579	0.0e+00	528	COG0443	Molecular chaperone DnaK (HSP70)	579
643873486	171	35.26	1	171	1	173	9.0e-20	90	COG1076	DnaJ-domain-containing proteins 1	174
643873487	107	58.33	1	107	3	110	4.0e-37	146	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
643873488	128	54.79	1	127	5	147	4.0e-37	146	COG0822	NifU homolog involved in Fe-S cluster formation	150
643873489	404	60.36	3	388	1	386	0.0e+00	554	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
643873490	171	40.28	4	146	1	144	4.0e-36	143	COG1959	DNA-binding transcriptional regulator, IscR family	150
643873491	243	51.04	2	242	1	238	4.0e-81	294	COG0565	tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase	242
643873492	174	46.75	9	162	3	154	4.0e-36	144	COG3154	Predicted lipid carrier protein YhbT, SCP2 domain	168
643873493	331	37.8	1	331	7	312	7.0e-83	301	COG0826	Collagenase-like protease, PrtC family	347
643873494	289	23.35	2	248	1	250	2.0e-42	166	COG0826	Collagenase-like protease, PrtC family	347
643873495	310	46.96	9	304	6	294	2.0e-74	272	COG4785	Lipoprotein NlpI, contains TPR repeats	297
643873496	124	33.96	20	121	5	107	1.0e-16	78.4	COG0607	Rhodanese-related sulfurtransferase	110
643873497	314	46.73	3	306	2	304	2.0e-84	305	COG0341	Preprotein translocase subunit SecF	305
643873498	617	47.9	75	617	1	506	0.0e+00	474	COG0342	Preprotein translocase subunit SecD	506
643873499	112	39.39	14	112	1	97	2.0e-21	94.5	COG1862	Preprotein translocase subunit YajC	97
643873500	373	61.62	3	372	1	369	0.0e+00	570	COG0343	Queuine/archaeosine tRNA-ribosyltransferase	372
643873501	348	57.43	1	346	1	345	0.0e+00	516	COG0809	S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)	348
643873503	219	51.98	1	219	1	227	2.0e-72	265	COG0120	Ribose 5-phosphate isomerase	227
643873504	342	22.44	1	292	5	302	8.0e-26	111	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
643873509	354	59.21	2	354	1	328	0.0e+00	515	COG1088	dTDP-D-glucose 4,6-dehydratase	340
643873510	182	59.32	1	177	1	173	1.0e-62	232	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	173
643873511	293	57.09	1	289	1	286	9.0e-115	406	COG1209	dTDP-glucose pyrophosphorylase	286
643873512	299	49.82	7	291	2	274	9.0e-84	303	COG1091	dTDP-4-dehydrorhamnose reductase	281
643873513	565	18.98	2	403	11	401	5.0e-10	59.8	COG3307	O-antigen ligase	424
643873514	487	42.92	251	487	1	226	5.0e-66	245	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
643873518	242	21.4	1	240	1	241	4.0e-11	62.1	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
643873519	456	36.77	1	456	4	462	2.0e-103	370	COG1109	Phosphomannomutase	464
643873520	465	56.89	1	331	1	333	0.0e+00	481	COG0836	Mannose-1-phosphate guanylyltransferase	333
643873521	155	27.94	13	147	4	129	2.0e-13	68.1	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
643873522	321	29.52	5	317	2	313	2.0e-43	169	COG0451	Nucleoside-diphosphate-sugar epimerase	314
643873523	371	73.6	1	356	2	345	0.0e+00	593	COG1089	GDP-D-mannose dehydratase	345
643873524	410	18.14	3	403	1	407	3.0e-07	50.1	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
643873525	372	29.68	16	361	9	338	9.0e-43	167	COG3765	LPS O-antigen chain length determinant protein, WzzB/FepE family	347
643873526	337	45.7	1	335	1	329	0.0e+00	486	COG1087	UDP-glucose 4-epimerase	329
643873527	112	32.99	1	96	1	92	5.0e-07	46.4	COG1669	Predicted nucleotidyltransferase	97
643873529	230	40.69	1	229	3	233	3.0e-42	165	COG0704	Phosphate uptake regulator	240
643873530	272	71.26	19	272	1	253	2.0e-130	458	COG1117	ABC-type phosphate transport system, ATPase component	253
643873531	548	41.79	1	278	8	287	5.0e-76	278	COG4985	ABC-type phosphate transport system, auxiliary component	289
643873532	745	48.23	14	745	13	733	0.0e+00	738	COG4590	ABC-type uncharacterized transport system, permease component	733
643873533	690	44.24	2	687	6	693	0.0e+00	755	COG0855	Polyphosphate kinase	696
643873534	496	41.26	2	486	1	492	1.0e-122	433	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	492
643873535	164	58.78	4	150	5	152	1.0e-49	189	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
643873536	324	34.04	1	315	1	318	1.0e-51	197	COG0226	ABC-type phosphate transport system, periplasmic component	318
643873537	432	31.74	79	425	99	447	1.0e-46	181	COG5002	Signal transduction histidine kinase	459
643873538	229	48.02	3	225	1	225	1.0e-64	239	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
643873539	1253	22.31	1	786	1	746	4.0e-31	130	COG0419	DNA repair exonuclease SbcCD ATPase subunit	908
643873540	411	24	1	342	1	321	1.0e-29	124	COG0420	DNA repair exonuclease SbcCD nuclease subunit	390
643873542	302	61.46	1	301	1	301	3.0e-114	404	COG2974	DNA recombination-dependent growth factor C	303
643873543	454	41.65	1	387	4	346	3.0e-110	392	COG0826	Collagenase-like protease, PrtC family	347
643873545	80	38.46	3	80	2	79	1.0e-15	74.6	COG0695	Glutaredoxin	80
643873546	267	48.08	1	258	1	260	3.0e-80	291	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
643873547	383	55.38	5	376	20	390	5.0e-90	324	COG3135	Predicted benzoate:H+ symporter BenE	402
643873549	658	40.11	469	649	1	181	1.0e-43	171	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643873550	272	38.87	5	272	2	282	2.0e-64	239	COG0169	Shikimate 5-dehydrogenase	283
643873551	456	23.72	4	389	1	386	2.0e-18	87.6	COG2814	Predicted arabinose efflux permease, MFS family	394
643873552	296	45.74	1	282	17	297	3.0e-77	282	COG0109	Polyprenyltransferase (heme O synthase)	304
643873553	109	59.63	1	109	3	111	4.0e-26	109	COG3125	Heme/copper-type cytochrome/quinol oxidase, subunit 4	111
643873554	204	47.52	4	204	10	209	1.0e-49	189	COG1845	Heme/copper-type cytochrome/quinol oxidase, subunit 3	209
643873555	663	56.1	38	608	1	566	0.0e+00	621	COG0843	Heme/copper-type cytochrome/quinol oxidase, subunit 1	566
643873556	312	47.45	7	261	1	247	3.0e-70	259	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	247
643873558	438	38.88	2	424	6	421	9.0e-97	347	COG1253	Hemolysin or related protein, contains CBS domains	429
643873561	197	47.28	1	183	1	183	5.0e-36	144	COG2119	Putative Ca2+/H+ antiporter, TMEM165/GDT1 family	190
643873562	273	23.72	30	258	23	271	3.0e-16	78.9	COG5607	CHAD domain (function unknown)	283
643873563	633	32.43	1	146	1	147	6.0e-30	126	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
643873563	633	47.86	282	631	1	343	4.0e-84	306	COG1299	Phosphotransferase system, fructose-specific IIC component	343
643873564	358	36.74	43	305	1	260	2.0e-64	239	COG1180	Pyruvate-formate lyase-activating enzyme	260
643873565	258	35.82	2	258	1	279	3.0e-42	165	COG1355	Predicted class III extradiol dioxygenase, MEMO1 family	279
643873566	196	33.67	5	192	3	196	3.0e-25	108	COG2078	Uncharacterized conserved protein, AMMECR1 domain	203
643873567	318	68.14	2	318	1	315	0.0e+00	502	COG0825	Acetyl-CoA carboxylase alpha subunit	317
643873568	1160	49.66	3	1158	1	1139	0.0e+00	1360	COG0587	DNA polymerase III, alpha subunit	1139
643873569	197	58.95	11	196	1	190	1.0e-69	255	COG0164	Ribonuclease HII	199
643873570	393	53.66	16	391	1	381	3.0e-130	458	COG0763	Lipid A disaccharide synthetase	381
643873571	263	55.38	3	262	1	260	3.0e-102	364	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	260
643873572	151	62.5	7	149	3	142	4.0e-50	190	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
643873573	342	53.85	1	336	2	338	3.0e-103	368	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	338
643873574	172	33.73	4	170	1	169	8.0e-19	86.9	COG2825	Periplasmic chaperone for outer membrane proteins, Skp family	170
643873575	807	40.54	1	807	1	766	0.0e+00	685	COG4775	Outer membrane protein assembly factor BamA	766
643873577	398	58.29	1	397	1	384	0.0e+00	535	COG0743	1-deoxy-D-xylulose 5-phosphate reductoisomerase	385
643873578	281	33.1	1	281	2	265	6.0e-31	128	COG0575	CDP-diglyceride synthetase	265
643873579	259	55.22	15	244	16	245	8.0e-92	329	COG0020	Undecaprenyl pyrophosphate synthase	245
643873580	185	58.38	1	185	3	187	2.0e-64	238	COG0233	Ribosome recycling factor	187
643873581	244	61.02	6	240	2	237	5.0e-91	327	COG0528	Uridylate kinase	238
643873582	292	58.45	1	289	1	296	1.0e-92	332	COG0264	Translation elongation factor EF-Ts	296
643873583	242	62.3	1	241	1	243	6.0e-101	360	COG0052	Ribosomal protein S2	252
643873585	263	55.47	1	254	1	255	1.0e-98	352	COG0024	Methionine aminopeptidase	255
643873586	878	47.71	7	877	2	866	0.0e+00	923	COG2844	UTP:GlnB (protein PII) uridylyltransferase	867
643873587	275	50.36	1	273	1	271	1.0e-79	289	COG2171	Tetrahydrodipicolinate N-succinyltransferase	271
643873588	339	28.99	1	336	1	333	6.0e-62	231	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643873589	705	38.93	3	691	1	687	0.0e+00	711	COG3345	Alpha-galactosidase	687
643873590	683	22.08	105	658	39	552	2.0e-51	197	COG0747	ABC-type transport system, periplasmic component	556
643873591	332	36.45	1	332	1	316	2.0e-71	262	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
643873592	374	40.08	123	374	43	288	1.0e-58	220	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
643873593	539	58.36	1	538	1	534	0.0e+00	752	COG4172	ABC-type microcin C transport system, duplicated ATPase component YejF	534
643873594	334	40.68	14	331	1	310	7.0e-78	284	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
643873595	300	27.78	163	288	1	126	5.0e-18	85.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643873596	438	40.67	1	438	4	442	6.0e-126	444	COG1486	Alpha-galactosidase/6-phospho-beta-glucosidase, family 4 of glycosyl hydrolase	442
643873597	176	22.09	28	176	14	174	3.0e-07	48.5	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
643873599	1237	61.17	330	1202	1	842	0.0e+00	1191	COG1410	Methionine synthase I, cobalamin-binding domain	842
643873600	315	66.11	1	301	1	301	0.0e+00	465	COG1897	Homoserine trans-succinylase	307
643873601	385	45.45	1	220	2	220	8.0e-62	231	COG1058	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	255
643873602	96	24.18	1	91	3	89	4.0e-13	66.5	COG2350	Uncharacterized conserved protein YciI, contains a putative active-site phosphohistidine	92
643873603	180	24.69	1	160	1	162	2.0e-17	81.9	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
643873604	259	47.57	39	243	5	204	5.0e-52	197	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	205
643873605	74	54.17	3	74	1	72	2.0e-10	57.3	COG2900	Uncharacterized coiled-coil protein SlyX (sensitive to lysis X)	72
643873606	553	36.35	20	530	1	472	1.0e-115	410	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	472
643873608	266	41.43	1	249	1	238	5.0e-61	227	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	238
643873609	383	46.98	1	378	1	377	1.0e-117	416	COG1820	N-acetylglucosamine-6-phosphate deacetylase	380
643873610	404	30.65	84	392	5	302	4.0e-48	185	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
643873611	109	40.2	2	102	4	105	3.0e-18	83.5	COG3085	Uncharacterized conserved protein YifE, UPF0438 family	112
643873612	285	27.87	1	275	1	285	3.0e-25	108	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873613	335	32.23	2	326	1	328	1.0e-64	240	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643873614	486	35.01	7	481	28	484	1.0e-94	340	COG1621	Sucrose-6-phosphate hydrolase SacC, GH32 family	486
643873615	185	34.08	1	171	1	161	4.0e-24	104	COG0622	Predicted phosphodiesterase	172
643873617	759	43.14	5	601	6	587	0.0e+00	566	COG0370	Fe2+ transport system protein B	653
643873618	75	34.67	1	75	1	74	1.0e-10	58.3	COG1918	Fe2+ transport system protein FeoA	75
643873619	791	30.85	2	791	1	788	0.0e+00	488	COG0417	DNA polymerase elongation subunit (family B)	792
643873621	224	31.96	1	215	1	218	4.0e-39	154	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
643873622	442	41.39	24	292	1	265	2.0e-67	250	COG0548	Acetylglutamate kinase	265
643873623	451	38.85	3	448	2	444	2.0e-113	402	COG0527	Aspartokinase	447
643873624	104	41.35	1	104	4	107	5.0e-14	69.4	COG4392	Branched-chain amino acid transport protein	107
643873625	248	33.62	16	247	3	232	1.0e-40	159	COG1296	Predicted branched-chain amino acid permease (azaleucine resistance)	238
643873626	173	38.79	4	168	4	168	3.0e-42	164	COG1247	L-amino acid N-acyltransferase YncA	169
643873627	289	33.03	181	289	17	125	2.0e-23	103	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
643873628	332	40.13	22	332	4	316	2.0e-57	216	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
643873629	499	52	1	498	2	500	0.0e+00	622	COG1129	ABC-type sugar transport system, ATPase component	500
643873630	327	23.29	8	326	15	320	7.0e-27	114	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
643873632	558	39.6	5	553	4	530	0.0e+00	548	COG1069	Ribulose kinase	544
643873633	232	38.43	1	229	3	218	2.0e-57	215	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
643873634	499	62.12	1	499	1	497	0.0e+00	703	COG2160	L-arabinose isomerase	497
643873635	317	38.98	5	313	1	238	3.0e-63	235	COG0176	Transaldolase	239
643873636	666	63.2	6	666	7	663	0.0e+00	1054	COG0021	Transketolase	663
643873637	550	52.27	1	548	1	544	0.0e+00	547	COG2985	Uncharacterized membrane protein YbjL, putative transporter	544
643873639	91	48.28	10	67	1	58	3.0e-15	73.5	COG3313	Predicted Fe-S protein YdhL, DUF1289 family	74
643873641	405	17.38	12	400	1	388	9.0e-14	71.8	COG2814	Predicted arabinose efflux permease, MFS family	394
643873643	525	68.97	207	525	1	315	0.0e+00	556	COG0519	GMP synthase, PP-ATPase domain/subunit	315
643873644	487	30	257	476	1	170	1.0e-32	134	COG0516	IMP dehydrogenase/GMP reductase	170
643873645	448	47.85	8	448	5	440	0.0e+00	487	COG1570	Exonuclease VII, large subunit	440
643873646	132	46.56	1	131	3	130	3.0e-39	153	COG1607	Acyl-CoA hydrolase	157
643873647	212	43.07	10	211	8	203	8.0e-36	143	COG2095	Small neutral amino acid transporter SnatA, MarC family	203
643873648	889	46	451	861	1	377	1.0e-116	415	COG1454	Alcohol dehydrogenase, class IV	377
643873649	240	32.04	1	181	2	207	5.0e-25	108	COG0778	Nitroreductase	207
643873650	251	48.76	1	238	7	248	2.0e-57	215	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
643873651	362	60.82	2	359	1	364	0.0e+00	542	COG0082	Chorismate synthase	369
643873652	311	40.97	14	299	1	276	6.0e-60	224	COG2890	Methylase of polypeptide chain release factors	280
643873653	174	45.3	1	173	1	181	7.0e-49	186	COG2840	DNA-nicking endonuclease, Smr domain	184
643873655	152	37.04	1	152	2	162	5.0e-31	126	COG2062	Phosphohistidine phosphatase SixA	163
643873656	929	33.95	2	911	13	920	0.0e+00	721	COG1025	Secreted/periplasmic Zn-dependent peptidases, insulinase-like	937
643873657	258	52.92	1	253	2	254	9.0e-82	296	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
643873659	209	46.19	1	208	1	208	8.0e-57	213	COG0125	Thymidylate kinase	208
643873660	350	37.69	14	347	1	337	4.0e-94	338	COG1559	Cell division protein YceG, involved in septum cleavage	342
643873661	269	27.5	1	269	3	280	3.0e-45	175	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
643873662	413	58.21	2	413	1	411	0.0e+00	503	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
643873663	78	64.1	1	78	3	80	3.0e-11	60.3	COG0236	Acyl carrier protein	80
643873664	244	46.64	1	241	1	250	4.0e-50	191	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643873665	311	55.52	1	307	1	308	5.0e-102	364	COG0331	Malonyl CoA-acyl carrier protein transacylase	310
643873666	318	54.83	1	318	2	322	8.0e-115	406	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
643873667	339	45.54	4	336	2	336	1.0e-102	366	COG0416	Fatty acid/phospholipid biosynthesis enzyme	338
643873668	54	50.91	1	54	1	55	2.0e-11	60.6	COG0333	Ribosomal protein L32	57
643873669	173	28.81	1	173	1	176	1.0e-26	112	COG1399	Uncharacterized metal-binding protein YceD, DUF177 family	176
643873670	195	40.76	4	186	3	184	2.0e-50	191	COG0424	Predicted house-cleaning NTP pyrophosphatase, Maf/HAM1 superfamily	193
643873671	220	31.8	1	214	1	217	2.0e-41	162	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
643873672	314	42.47	8	303	1	289	1.0e-76	279	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
643873673	950	54.36	1	491	1	487	0.0e+00	531	COG1530	Ribonuclease G or E	487
643873674	252	37.68	31	236	7	213	9.0e-39	153	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
643873675	302	24	156	299	7	151	1.0e-09	57.7	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
643873676	302	33.6	14	263	1	246	2.0e-50	193	COG0037	tRNA(Ile)-lysidine synthase TilS/MesJ	298
643873677	268	35.85	46	256	51	258	2.0e-40	159	COG2992	Uncharacterized FlgJ-related protein	262
643873678	314	37.67	14	312	9	308	1.0e-68	253	COG1560	Lauroyl/myristoyl acyltransferase	308
643873679	331	45.27	1	331	4	341	1.0e-92	333	COG1816	Adenosine deaminase	345
643873680	555	36.61	1	547	1	535	3.0e-128	452	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	542
643873681	123	40.18	10	121	3	114	4.0e-13	67.1	COG1380	Putative effector of murein hydrolase LrgA, UPF0299 family	128
643873682	228	45.74	1	223	5	227	2.0e-52	199	COG1346	Putative effector of murein hydrolase	230
643873684	325	45.45	1	317	2	315	2.0e-95	342	COG0276	Protoheme ferro-lyase (ferrochelatase)	320
643873685	214	41.28	1	214	1	178	9.0e-48	183	COG0563	Adenylate kinase or related kinase	178
643873686	633	58.53	6	631	3	618	0.0e+00	825	COG0326	Molecular chaperone, HSP90 family	623
643873687	200	53.77	1	199	1	198	9.0e-76	276	COG0353	Recombinational DNA repair protein RecR	198
643873688	110	60.75	1	107	1	105	1.0e-25	108	COG0718	Conserved DNA-binding protein YbaB (function unknown)	105
643873689	760	42.29	1	474	1	477	1.0e-126	447	COG2812	DNA polymerase III, gamma/tau subunits	515
643873690	181	44.63	4	180	3	179	3.0e-45	174	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	179
643873691	220	27.78	13	220	7	216	9.0e-23	100	COG3110	Uncharacterized conserved protein YccT, UPF0319 family	216
643873692	431	53.38	16	429	3	389	0.0e+00	521	COG0448	ADP-glucose pyrophosphorylase	393
643873693	528	27.8	289	528	4	244	3.0e-33	136	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
643873694	237	27.2	1	230	2	239	6.0e-35	140	COG2186	DNA-binding transcriptional regulator, FadR family	241
643873695	110	61.17	1	102	2	104	6.0e-44	168	COG0278	Glutaredoxin-related protein	105
643873696	193	55.28	1	193	2	200	1.0e-72	265	COG0605	Superoxide dismutase	204
643873697	291	71.23	1	291	1	292	1.0e-123	436	COG0074	Succinyl-CoA synthetase, alpha subunit	293
643873698	389	63.24	1	387	1	386	0.0e+00	553	COG0045	Succinyl-CoA synthetase, beta subunit	387
643873699	398	48.66	1	397	1	404	1.0e-115	410	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	404
643873700	937	57.67	13	936	3	906	0.0e+00	1307	COG0567	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	906
643873701	430	53.18	39	429	12	390	0.0e+00	472	COG0372	Citrate synthase	390
643873702	339	59.82	4	334	1	325	0.0e+00	464	COG0158	Fructose-1,6-bisphosphatase	326
643873703	254	63.6	1	250	2	245	1.0e-104	373	COG1212	CMP-2-keto-3-deoxyoctulosonic acid synthetase	247
643873704	62	61.4	3	59	1	57	1.0e-14	71	COG2835	Uncharacterized conserved protein YbaR, Trm112 family	60
643873705	326	47.75	1	321	4	333	5.0e-96	344	COG1663	Tetraacyldisaccharide-1-P 4'-kinase	336
643873706	589	43.11	14	586	1	567	0.0e+00	491	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
643873707	738	32.09	436	718	1	287	4.0e-57	216	COG2333	Metal-dependent hydrolase, beta-lactamase superfamily II	293
643873708	200	26.4	3	199	10	205	4.0e-28	118	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
643873709	413	40.82	1	411	1	405	1.0e-94	340	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
643873710	227	45.45	5	223	1	220	2.0e-75	275	COG1136	ABC-type lipoprotein export system, ATPase component	226
643873711	411	43.2	5	411	1	408	6.0e-100	358	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
643873712	1150	53.41	9	1148	4	1136	0.0e+00	1461	COG1197	Transcription-repair coupling factor (superfamily II helicase)	1139
643873713	720	64.02	1	692	2	691	0.0e+00	995	COG1185	Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)	692
643873714	89	58.43	1	89	1	89	3.0e-27	113	COG0184	Ribosomal protein S15P/S13E	89
643873715	324	39.94	3	310	5	269	8.0e-69	254	COG0130	tRNA U55 pseudouridine synthase TruB, may also work on U342 of tmRNA	271
643873716	134	48.31	1	118	1	117	8.0e-30	122	COG0858	Ribosome-binding factor A	118
643873717	910	65.09	408	910	1	507	0.0e+00	693	COG0532	Translation initiation factor IF-2, a GTPase	509
643873718	499	50.53	160	346	1	182	8.0e-50	191	COG0195	Transcription antitermination factor NusA, contains S1 and KH domains	190
643873719	152	47.68	1	151	3	153	2.0e-48	185	COG0779	Ribosome maturation factor RimP	153
643873722	115	53.16	1	79	1	78	3.0e-18	83.7	COG1314	Preprotein translocase subunit SecG	86
643873723	444	47.38	1	443	5	460	5.0e-123	434	COG1109	Phosphomannomutase	464
643873724	280	50.39	15	268	8	261	7.0e-76	277	COG0294	Dihydropteroate synthase	274
643873725	641	62.14	6	597	1	592	0.0e+00	795	COG0465	ATP-dependent Zn proteases	596
643873726	209	57.92	7	208	1	202	5.0e-75	274	COG0293	23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ	205
643873727	97	54.64	2	97	1	97	3.0e-25	106	COG1534	RNA-binding protein YhbY	97
643873728	158	50.33	6	158	1	151	2.0e-42	165	COG0782	Transcription elongation factor, GreA/GreB family	151
643873729	376	64.36	1	373	1	371	0.0e+00	505	COG0484	DnaJ-class molecular chaperone with C-terminal Zn finger domain	371
643873730	644	59.9	1	605	4	579	0.0e+00	663	COG0443	Molecular chaperone DnaK (HSP70)	579
643873731	197	43.68	3	191	4	193	4.0e-42	164	COG0576	Molecular chaperone GrpE (heat shock protein)	193
643873732	294	43.21	6	291	1	281	2.0e-74	272	COG0061	NAD kinase	281
643873733	555	48.56	1	552	1	552	0.0e+00	576	COG0497	DNA repair ATPase RecN	557
643873734	133	31.09	21	128	2	120	1.0e-17	82.4	COG2913	Outer membrane protein assembly factor BamE, lipoprotein component of the BamABCDE complex	147
643873735	99	53.76	2	94	1	93	1.0e-24	104	COG2914	Putative antitoxin component PasI (RatB) of the RatAB toxin-antitoxin module, ubiquitin-RnfH superfamily	99
643873736	144	51.72	1	144	1	145	2.0e-48	184	COG2867	Ribosome association toxin PasT (RatA) of the RatAB toxin-antitoxin module	146
643873737	160	60.39	7	160	1	153	6.0e-56	210	COG0691	tmRNA-binding protein	153
643873738	415	23.3	97	395	5	309	3.0e-11	63.1	COG0582	Integrase	309
643873741	594	17.62	5	569	11	504	3.0e-15	77.3	COG0433	Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase domains	520
643873743	1009	22.04	36	1006	10	911	8.0e-117	415	COG0610	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ...	962
643873744	331	26.69	3	325	9	344	7.0e-38	151	COG3177	Fic family protein	348
643873745	421	21.72	56	417	38	391	1.0e-12	67.8	COG0732	Restriction endonuclease S subunit	391
643873746	797	30.02	6	491	4	422	9.0e-63	235	COG0286	Type I restriction-modification system, DNA methylase subunit	489
643873750	117	37.1	54	115	11	66	7.0e-11	59.2	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
643873753	327	37.78	11	321	7	314	9.0e-49	187	COG5377	Phage-related protein, predicted endonuclease	319
643873763	323	46.88	1	319	8	319	1.0e-52	200	COG0530	Ca2+/Na+ antiporter	320
643873765	383	43.81	3	378	1	377	5.0e-103	368	COG1454	Alcohol dehydrogenase, class IV	377
643873766	203	27.15	37	187	7	147	2.0e-23	102	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
643873767	178	31.46	4	168	2	178	2.0e-21	95.4	COG1514	2'-5' RNA ligase	180
643873768	149	55.56	30	146	1	117	1.0e-29	122	COG1734	RNA polymerase-binding transcription factor DksA	120
643873770	1023	36.55	3	1013	2	1007	0.0e+00	895	COG0841	Multidrug efflux pump subunit AcrB	1009
643873771	373	32.79	5	369	8	372	1.0e-30	127	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
643873772	521	34.32	79	510	2	412	3.0e-85	309	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
643873773	161	48.75	1	160	1	159	3.0e-47	181	COG0801	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	160
643873774	264	53.23	3	263	1	263	3.0e-100	358	COG0413	Ketopantoate hydroxymethyltransferase	268
643873775	288	58.04	1	284	1	285	2.0e-106	378	COG0414	Panthothenate synthetase	285
643873776	126	55.2	2	126	1	125	7.0e-47	179	COG0853	Aspartate 1-decarboxylase	126
643873777	197	55.5	4	194	1	190	1.0e-74	272	COG0193	Peptidyl-tRNA hydrolase	190
643873778	363	62.1	1	363	1	372	0.0e+00	527	COG0012	Ribosome-binding ATPase YchF, GTP1/OBG family	372
643873779	810	33.33	8	809	1	755	0.0e+00	740	COG1882	Pyruvate-formate lyase	755
643873780	304	26.03	1	290	20	246	2.0e-32	133	COG1180	Pyruvate-formate lyase-activating enzyme	260
643873781	217	34.06	1	217	8	236	7.0e-51	193	COG0176	Transaldolase	239
643873787	432	59.5	1	432	1	426	0.0e+00	579	COG0172	Seryl-tRNA synthetase	429
643873788	448	58.89	7	437	5	433	0.0e+00	604	COG2256	Replication-associated recombination protein RarA (DNA-dependent ATPase)	436
643873789	207	34.27	1	207	1	211	5.0e-33	134	COG2834	Outer membrane lipoprotein-sorting protein	211
643873790	870	31.07	12	867	8	856	0.0e+00	568	COG1674	DNA segregation ATPase FtsK/SpoIIIE and related proteins	858
643873791	163	50	7	160	2	154	2.0e-36	145	COG1522	DNA-binding transcriptional regulator, Lrp family	154
643873792	374	62.26	1	371	1	371	0.0e+00	495	COG0686	Alanine dehydrogenase	371
643873793	318	50.63	5	318	2	305	6.0e-93	334	COG0492	Thioredoxin reductase	305
643873794	234	56.82	14	233	3	221	1.0e-84	306	COG2360	Leu/Phe-tRNA-protein transferase	221
643873795	247	44.26	6	233	10	244	9.0e-63	233	COG2935	Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase	253
643873796	72	69.44	1	72	1	72	8.0e-26	108	COG0361	Translation initiation factor IF-1	75
643873797	758	46.78	1	750	1	785	0.0e+00	865	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
643873798	104	52.88	1	104	4	107	9.0e-32	128	COG2127	ATP-dependent Clp protease adapter protein ClpS	107
643873799	72	57.58	1	66	1	66	1.0e-23	101	COG1278	Cold shock protein, CspA family	67
643873800	417	67.24	11	417	3	406	0.0e+00	615	COG0538	Isocitrate dehydrogenase	407
643873801	151	30.51	4	120	8	122	1.0e-08	52.7	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
643873802	369	62.53	4	364	1	355	0.0e+00	516	COG0482	tRNA U34 2-thiouridine synthase MnmA/TrmU, contains the PP-loop ATPase domain	356
643873803	207	51.24	8	207	7	207	3.0e-59	221	COG2915	Regulator of phage lambda lysogenization HflD, binds to CII and stimulates its degradation	207
643873804	456	35.31	12	456	1	436	2.0e-116	413	COG0015	Adenylosuccinate lyase	438
643873805	530	39.25	15	529	26	549	1.0e-130	460	COG3604	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains	550
643873807	192	56.32	1	190	1	190	5.0e-54	203	COG4657	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfA subunit	193
643873808	183	46.43	5	166	6	173	2.0e-37	148	COG2878	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit	198
643873809	483	40.8	10	471	8	478	1.0e-110	393	COG4656	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfC subunit	529
643873810	326	42.25	6	319	7	335	8.0e-76	277	COG4658	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfD subunit	338
643873811	208	41.27	15	199	6	194	2.0e-44	172	COG4659	Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfG subunit	195
643873812	228	55.1	4	199	5	200	9.0e-61	226	COG4660	Na+-translocating ferredoxin:NAD+ oxidoreductase  RNF, RnfE subunit	212
643873813	86	33.78	1	74	4	77	7.0e-11	58.8	COG2914	Putative antitoxin component PasI (RatB) of the RatAB toxin-antitoxin module, ubiquitin-RnfH superfamily	99
643873814	443	19.38	46	381	11	385	5.0e-06	46.3	COG1055	Na+/H+ antiporter NhaD or related arsenite permease	424
643873815	178	36.72	1	176	1	151	9.0e-27	113	COG0716	Flavodoxin	151
643873816	416	26.67	1	403	2	420	3.0e-26	113	COG0531	Amino acid transporter	466
643873817	391	28.85	141	387	33	281	3.0e-26	112	COG1408	Predicted phosphohydrolase, MPP superfamily	284
643873818	279	20.24	29	268	54	292	2.0e-06	46.6	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
643873821	387	36.62	12	387	3	387	2.0e-88	319	COG0119	Isopropylmalate/homocitrate/citramalate synthases	409
643873822	460	57.43	4	444	6	449	0.0e+00	531	COG1113	L-asparagine transporter and related permeases	462
643873823	290	39.38	4	288	19	307	2.0e-68	252	COG3386	Sugar lactone lactonase YvrE	307
643873824	341	45.91	1	341	9	340	5.0e-84	304	COG0798	Arsenite efflux pump ArsB, ACR3 family	342
643873826	338	49.4	2	334	1	331	8.0e-118	416	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	335
643873827	220	40.95	2	206	1	210	7.0e-39	153	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
643873829	294	32.11	1	292	1	293	5.0e-31	128	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873830	247	40.76	15	245	7	242	4.0e-57	214	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
643873831	562	45.77	1	554	1	508	0.0e+00	539	COG0155	Sulfite reductase, beta subunit (hemoprotein)	510
643873832	605	49.75	15	605	1	587	0.0e+00	601	COG0369	Sulfite reductase, alpha subunit (flavoprotein)	587
643873834	468	44.16	2	462	9	471	0.0e+00	505	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	472
643873836	242	33.9	57	231	5	181	1.0e-38	153	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643873839	675	23.53	392	661	99	360	1.0e-21	99	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
643873841	959	24.53	70	944	1	842	2.0e-50	194	COG0553	Superfamily II DNA or RNA helicase, SNF2 family	866
643873842	220	44.04	9	218	73	289	1.0e-57	216	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
643873843	277	28.64	73	271	3	174	5.0e-24	105	COG1076	DnaJ-domain-containing proteins 1	174
643873845	328	33.43	4	321	13	345	5.0e-59	221	COG3178	Predicted phosphotransferase, aminoglycoside/choline kinase (APH/ChoK) family	351
643873846	789	32.26	65	785	52	784	1.0e-116	414	COG1452	LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA)	784
643873848	329	53.19	3	329	2	330	3.0e-116	411	COG1995	4-hydroxy-L-threonine phosphate dehydrogenase PdxA	332
643873849	268	47.49	11	268	3	258	2.0e-86	312	COG0030	16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity)	259
643873850	123	45.08	2	123	6	126	2.0e-37	147	COG2967	Uncharacterized protein affecting Mg2+/Co2+ transport	126
643873852	163	51.79	2	161	1	166	2.0e-44	171	COG0262	Dihydrofolate reductase	167
643873853	154	38.96	3	154	2	155	2.0e-18	84.9	COG3610	Uncharacterized membrane protein YjjB, DUF3815 family	156
643873854	264	36.25	3	249	2	250	3.0e-46	178	COG2966	Uncharacterized membrane protein YjjP, DUF1212 family	250
643873856	393	62.71	1	359	1	361	0.0e+00	524	COG0536	GTPase involved in cell partioning and DNA repair	369
643873857	85	77.65	1	85	1	84	2.0e-30	124	COG0211	Ribosomal protein L27	87
643873858	103	62.14	1	103	1	103	1.0e-34	137	COG0261	Ribosomal protein L21	103
643873859	323	38.56	11	322	8	321	3.0e-79	288	COG0142	Geranylgeranyl pyrophosphate synthase	322
643873860	432	63.11	2	431	1	430	0.0e+00	664	COG0104	Adenylosuccinate synthase	430
643873861	296	29.77	1	288	2	287	9.0e-43	167	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
643873862	390	29.31	57	338	5	291	3.0e-48	186	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
643873863	429	51.82	6	418	1	406	1.0e-124	440	COG2262	50S ribosomal subunit-associated GTPase HflX	411
643873864	85	78.08	1	72	1	73	2.0e-27	113	COG1923	sRNA-binding regulator protein Hfq	77
643873865	310	54.33	5	303	1	298	2.0e-106	379	COG0324	tRNA A37 N6-isopentenylltransferase MiaA	308
643873866	594	43.72	1	523	1	564	0.0e+00	521	COG0323	DNA mismatch repair ATPase MutL	638
643873867	531	35.47	227	460	37	231	5.0e-49	189	COG0860	N-acetylmuramoyl-L-alanine amidase	231
643873868	155	53.69	5	152	1	149	7.0e-46	176	COG0802	tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE	149
643873869	483	43.17	203	469	8	283	1.0e-64	240	COG0063	NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain	284
643873870	375	54.55	10	348	2	337	2.0e-109	389	COG1600	Epoxyqueuosine reductase  QueG (queuosine biosynthesis)	337
643873871	247	26.77	1	247	6	311	4.0e-28	118	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
643873872	301	25.18	21	289	4	271	2.0e-22	100	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
643873875	79	45	11	70	10	69	5.0e-14	69.6	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
643873876	287	30.15	1	270	2	258	3.0e-34	139	COG1192	Cellulose biosynthesis protein BcsQ	259
643873883	133	24.46	1	132	2	136	7.0e-18	82.8	COG0629	Single-stranded DNA-binding protein	167
643873884	669	31.02	1	614	1	564	0.0e+00	482	COG0550	DNA topoisomerase IA	570
643873904	604	25.89	20	597	4	640	2.0e-56	214	COG0210	Superfamily I DNA or RNA helicase	655
643873905	595	19.93	1	572	1	565	2.0e-45	177	COG3593	Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains	581
643873934	302	51.28	1	300	1	311	3.0e-97	348	COG0549	Carbamate kinase	312
643873935	333	52.87	2	332	1	310	9.0e-129	453	COG0078	Ornithine carbamoyltransferase	310
643873936	409	43.13	3	409	2	409	1.0e-126	446	COG2235	Arginine deiminase	409
643873937	481	46.97	16	481	9	481	0.0e+00	466	COG1288	Uncharacterized membrane protein YfcC, ion transporter superfamily	481
643873940	210	26.63	19	186	12	180	2.0e-10	58.9	COG1309	DNA-binding transcriptional regulator, AcrR family	201
643873941	495	42.06	28	473	1	445	1.0e-68	254	COG1538	Outer membrane protein TolC	457
643873942	359	27.11	8	280	12	273	3.0e-25	109	COG1566	Multidrug resistance efflux pump	352
643873943	922	46.12	277	506	4	235	2.0e-69	257	COG1131	ABC-type multidrug transport system, ATPase component	293
643873944	376	28.42	87	370	15	281	7.0e-18	85.3	COG0842	ABC-type multidrug transport system, permease component	286
643873946	248	43.08	1	245	1	250	9.0e-45	173	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643873948	473	29.19	180	469	9	327	2.0e-48	187	COG0280	Phosphotransacetylase	327
643873949	250	44.27	4	248	2	251	6.0e-41	161	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643873950	413	41.52	16	404	2	390	5.0e-109	388	COG0282	Acetate kinase	396
643873951	401	38.61	2	400	4	397	9.0e-70	257	COG0786	Na+/glutamate symporter	404
643873952	583	42.79	132	582	7	444	3.0e-118	419	COG3243	Poly(3-hydroxyalkanoate) synthetase	445
643873953	164	32.45	1	148	4	153	1.0e-15	75.8	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
643873954	357	20.26	43	345	35	319	1.0e-21	97.4	COG3528	Uncharacterized protein	330
643873956	298	31.99	6	290	8	301	2.0e-53	202	COG0462	Phosphoribosylpyrophosphate synthetase	314
643873957	792	24.43	45	748	21	737	2.0e-113	404	COG3957	Phosphoketolase	793
643873958	452	35.02	2	452	1	427	4.0e-84	305	COG1236	RNA processing exonuclease, beta-lactamase fold, Cft2 family	427
643873959	505	34.05	99	496	2	415	3.0e-97	349	COG0213	Thymidine phosphorylase	435
643873960	296	35.12	1	296	1	293	3.0e-33	135	COG0583	DNA-binding transcriptional regulator, LysR family	297
643873961	97	40	29	83	6	60	3.0e-07	46.7	COG1476	DNA-binding transcriptional regulator, XRE-family HTH domain	68
643873963	643	21.94	98	408	14	309	1.0e-05	45.7	COG0582	Integrase	309
643873967	181	66.3	1	181	1	181	2.0e-81	294	COG1949	Oligoribonuclease (3'-5' exoribonuclease)	184
643873968	344	41.67	29	340	3	300	6.0e-94	337	COG1162	Putative ribosome biogenesis GTPase RsgA	301
643873969	291	31.5	12	280	3	237	2.0e-54	205	COG0688	Phosphatidylserine decarboxylase	239
643873970	589	52.77	1	571	2	562	0.0e+00	603	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	562
643873971	246	48.32	3	240	1	234	8.0e-81	293	COG0479	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit	234
643873972	134	42.97	6	133	2	129	2.0e-29	121	COG3029	Fumarate reductase subunit C	129
643873973	116	50	2	115	7	118	9.0e-21	92.2	COG3080	Fumarate reductase subunit D	118
643873974	347	23.79	140	345	3	168	1.0e-26	114	COG0516	IMP dehydrogenase/GMP reductase	170
643873975	305	33.22	8	305	5	310	8.0e-29	121	COG0679	Predicted permease	311
643873976	225	34.22	6	225	4	212	8.0e-43	167	COG0602	Organic radical activating enzyme	212
643873977	149	54.36	1	149	1	147	1.0e-41	162	COG0359	Ribosomal protein L9	148
643873978	76	72.06	1	68	8	75	3.0e-20	89.9	COG0238	Ribosomal protein S18	75
643873979	124	52.68	2	112	1	112	8.0e-34	135	COG0360	Ribosomal protein S6	112
643873980	213	53.14	37	211	1	172	8.0e-64	236	COG0225	Peptide methionine sulfoxide reductase MsrA	174
643873982	485	39.95	1	386	2	383	3.0e-106	379	COG0301	Adenylyl- and sulfurtransferase ThiI, participates in tRNA 4-thiouridine and thiamine biosynthesis	383
643873983	88	48.05	3	79	4	80	4.0e-08	49.6	COG1722	Exonuclease VII small subunit	81
643873984	296	39.1	1	296	1	322	4.0e-63	234	COG0142	Geranylgeranyl pyrophosphate synthase	322
643873985	627	63.18	15	627	2	623	0.0e+00	963	COG1154	Deoxyxylulose-5-phosphate synthase	627
643873986	141	37.39	4	118	3	117	1.0e-34	138	COG1393	Arsenate reductase and related proteins, glutaredoxin family	117
643873987	102	30.3	1	99	10	106	7.0e-09	52.1	COG0640	DNA-binding transcriptional regulator, ArsR family	110
643873988	311	31.49	3	309	1	306	1.0e-34	140	COG0679	Predicted permease	311
643873990	311	42.72	6	307	2	285	2.0e-73	269	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
643873991	325	39.56	1	320	1	315	3.0e-77	282	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
643873992	518	29.06	20	518	37	555	3.0e-75	276	COG0747	ABC-type transport system, periplasmic component	556
643873993	583	50.63	1	559	3	534	0.0e+00	682	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
643873994	704	22.5	5	164	7	160	2.0e-08	55	COG4967	Tfp pilus assembly protein PilV	162
643873997	178	25.14	2	167	4	175	7.0e-14	70.4	COG4970	Tfp pilus assembly protein FimT	181
643873998	128	37.41	1	127	1	139	6.0e-26	109	COG4968	Tfp pilus assembly protein PilE	139
643873999	167	44.74	15	163	9	159	6.0e-32	130	COG1267	Phosphatidylglycerophosphatase A	160
643874000	328	46.27	1	319	3	317	1.0e-80	293	COG0611	Thiamine monophosphate kinase	317
643874001	138	48.53	6	134	10	145	3.0e-36	143	COG0781	Transcription termination factor NusB	151
643874002	156	60.13	1	153	1	152	7.0e-52	196	COG0054	6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)	152
643874003	368	59.61	1	203	1	202	1.0e-82	300	COG0108	3,4-dihydroxy-2-butanone 4-phosphate synthase	203
643874004	219	53.88	1	205	1	203	2.0e-69	255	COG0307	Riboflavin synthase alpha chain	204
643874005	370	69.86	1	146	1	146	8.0e-64	237	COG0117	Pyrimidine deaminase domain of riboflavin biosynthesis protein RibD	146
643874006	149	62.42	1	149	1	149	4.0e-57	213	COG1327	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains	156
643874007	417	68.28	5	416	4	412	0.0e+00	684	COG0112	Glycine/serine hydroxymethyltransferase	413
643874008	152	63.45	6	150	2	146	3.0e-60	223	COG0757	3-dehydroquinate dehydratase	146
643874009	148	45.21	6	148	1	139	4.0e-26	110	COG0511	Biotin carboxyl carrier protein	140
643874010	446	66.14	1	444	1	445	0.0e+00	635	COG0439	Biotin carboxylase	449
643874012	292	46.49	1	291	2	300	1.0e-89	323	COG2264	Ribosomal protein L11 methylase PrmA	300
643874013	322	44.86	1	318	2	319	1.0e-90	326	COG0042	tRNA-dihydrouridine synthase	323
643874014	99	63.64	1	99	1	98	6.0e-32	128	COG2901	DNA-binding protein Fis (factor for inversion stimulation)	98
643874015	540	25.31	3	529	1	553	4.0e-66	246	COG2194	Phosphoethanolamine transferase for periplasmic glucans (OPG), alkaline phosphatase superfamily	555
643874016	483	47.37	226	468	1	246	1.0e-72	267	COG1119	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA	257
643874019	200	50	1	198	1	186	9.0e-68	249	COG0163	3-polyprenyl-4-hydroxybenzoate decarboxylase	191
643874020	456	41.77	2	451	9	459	0.0e+00	486	COG0773	UDP-N-acetylmuramate-alanine ligase	459
643874021	177	58.29	1	175	1	171	3.0e-57	214	COG0221	Inorganic pyrophosphatase	171
643874023	198	63.08	4	198	2	196	1.0e-83	302	COG0529	Adenylylsulfate kinase or related kinase	197
643874024	472	64.73	21	451	1	431	0.0e+00	660	COG2895	Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family	431
643874025	304	35.2	9	304	17	261	7.0e-60	224	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
643874026	468	60.91	214	454	4	244	1.0e-86	314	COG0007	Uroporphyrinogen-III methylase (siroheme synthase)	244
643874027	306	40.2	3	296	1	291	5.0e-52	198	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
643874028	156	35.25	12	150	3	138	8.0e-21	93	COG1585	Membrane protein implicated in regulation of membrane protease activity	140
643874029	329	32.1	1	312	1	313	6.0e-59	221	COG0039	Malate/lactate dehydrogenase	313
643874030	156	47.33	6	152	3	150	5.0e-40	156	COG1438	Arginine repressor	150
643874031	536	44.74	6	534	6	536	0.0e+00	490	COG3290	Sensor histidine kinase regulating citrate/malate metabolism	537
643874032	549	44.81	38	344	1	297	1.0e-102	367	COG1951	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain	297
643874033	503	37.37	20	503	1	460	3.0e-52	199	COG0471	Di- and tricarboxylate transporter	461
643874034	926	39.3	3	339	2	335	4.0e-87	316	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
643874035	343	35.33	6	337	9	337	4.0e-76	278	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
643874036	244	46.55	2	233	1	224	3.0e-74	271	COG4565	Response regulator of citrate/malate metabolism	224
643874037	344	34.84	1	340	3	351	3.0e-90	325	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
643874038	544	33.51	1	541	4	534	1.0e-75	277	COG1178	ABC-type Fe3+ transport system, permease component	540
643874039	332	28.16	35	331	1	299	3.0e-43	169	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
643874040	112	69.64	1	112	1	112	3.0e-38	150	COG0347	Nitrogen regulatory protein PII	112
643874041	122	36.89	1	122	1	121	2.0e-21	94.2	COG3112	Uncharacterized protein YacL, UPF0231 family	121
643874042	865	81.3	1	861	1	852	0.0e+00	1519	COG1049	Aconitase B	852
643874044	127	42.06	1	125	1	126	7.0e-19	86	COG0239	Fluoride ion exporter CrcB/FEX, affects chromosome condensation	126
643874045	105	30.23	1	85	4	89	4.0e-10	56.4	COG1993	PII-like signaling protein	109
643874046	423	19.78	4	364	1	338	3.0e-22	100	COG0446	NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase	415
643874048	342	27.19	4	325	21	351	5.0e-25	108	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
643874049	1053	28.31	10	1045	1	1003	0.0e+00	641	COG0841	Multidrug efflux pump subunit AcrB	1009
643874050	403	33.52	10	187	1	179	1.0e-32	134	COG2059	Chromate transport protein ChrA	195
643874052	451	28.98	1	442	1	455	2.0e-72	266	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
643874053	291	48.42	6	290	2	286	8.0e-84	303	COG2084	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase	286
643874054	475	51.2	4	457	2	454	0.0e+00	486	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
643874055	629	42.92	201	629	1	403	5.0e-95	342	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	404
643874056	890	71.52	1	890	1	887	0.0e+00	1427	COG2609	Pyruvate dehydrogenase complex, dehydrogenase (E1) component	887
643874057	252	37.76	5	242	5	241	7.0e-42	164	COG2186	DNA-binding transcriptional regulator, FadR family	241
643874058	386	56.32	5	384	2	374	8.0e-114	403	COG3835	Sugar diacid utilization regulator	376
643874059	378	65.87	1	375	1	375	0.0e+00	509	COG1929	Glycerate kinase	378
643874060	296	51.58	4	287	2	286	6.0e-82	297	COG2084	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase	286
643874061	256	53.97	6	256	4	255	5.0e-92	331	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	255
643874062	445	26.46	7	414	1	371	7.0e-57	214	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
643874063	444	28.61	7	414	1	372	4.0e-62	232	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
643874064	446	22.01	18	435	27	433	2.0e-28	120	COG2271	Sugar phosphate permease	448
643874065	521	47.29	116	521	5	381	1.0e-128	453	COG2721	Altronate dehydratase	381
643874067	279	52.65	1	279	1	278	2.0e-91	329	COG0157	Nicotinate-nucleotide pyrophosphorylase	280
643874068	270	41.64	2	269	1	262	7.0e-56	210	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
643874069	457	53.32	1	449	3	452	0.0e+00	491	COG1115	Na+/alanine symporter	452
643874070	91	60.44	1	91	2	92	2.0e-29	120	COG0776	Bacterial nucleoid DNA-binding protein	94
643874071	192	32.99	1	191	1	194	1.0e-32	133	COG3068	Uncharacterized protein YjaG, DUF416 family	194
643874072	525	30.94	297	518	61	276	1.0e-30	128	COG0739	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain	277
643874073	355	55.75	6	352	7	352	3.0e-127	448	COG0407	Uroporphyrinogen-III decarboxylase	352
643874074	168	38.16	1	149	1	150	1.0e-31	129	COG3160	Regulator of sigma D	162
643874075	454	58.68	1	454	1	453	0.0e+00	646	COG1066	Predicted ATP-dependent serine protease	456
643874076	332	48.31	118	323	5	211	1.0e-53	203	COG0560	Phosphoserine phosphatase	212
643874077	236	68.94	1	235	1	235	6.0e-109	386	COG0813	Purine-nucleoside phosphorylase	236
643874078	408	59.36	1	404	1	393	0.0e+00	564	COG1015	Phosphopentomutase	397
643874079	443	51.48	1	439	1	435	0.0e+00	525	COG0213	Thymidine phosphorylase	435
643874080	256	36.99	4	249	1	225	4.0e-55	208	COG0274	Deoxyribose-phosphate aldolase	228
643874081	256	39.22	1	253	2	255	6.0e-74	270	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
643874083	528	73.95	3	528	4	528	0.0e+00	920	COG4108	Peptide chain release factor RF-3	528
643874085	245	46.09	3	244	21	258	3.0e-67	248	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
643874086	806	47.91	18	729	3	706	0.0e+00	743	COG0557	Exoribonuclease R	706
643874087	300	33.45	1	294	1	292	2.0e-40	159	COG0583	DNA-binding transcriptional regulator, LysR family	297
643874088	132	41.84	32	129	1	98	2.0e-13	68.1	COG3783	Soluble cytochrome b562	100
643874091	334	53.77	1	312	3	314	8.0e-113	400	COG0180	Tryptophanyl-tRNA synthetase	314
643874092	227	40	6	225	3	218	2.0e-48	185	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
643874093	226	60.81	3	224	1	220	3.0e-87	314	COG0036	Pentose-5-phosphate-3-epimerase	220
643874094	279	47.27	3	272	1	274	2.0e-66	245	COG0338	Site-specific DNA-adenine methylase	274
643874095	518	23.13	258	517	42	292	4.0e-12	66.7	COG3266	Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain	292
643874096	358	59.44	1	358	1	358	0.0e+00	488	COG0337	3-dehydroquinate synthetase	360
643874097	172	53.29	4	170	2	166	6.0e-51	193	COG0703	Shikimate kinase	172
643874098	290	48.98	1	290	4	297	1.0e-83	302	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
643874099	209	33.68	9	195	1	190	7.0e-38	150	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
643874100	114	50.82	19	79	6	65	2.0e-13	67.3	COG1923	sRNA-binding regulator protein Hfq	77
643874102	848	45.97	1	841	1	795	0.0e+00	905	COG5009	Membrane carboxypeptidase/penicillin-binding protein	797
643874103	356	31.65	1	351	1	353	1.0e-58	220	COG4972	Tfp pilus assembly protein, ATPase PilM	354
643874104	189	32.14	1	168	4	171	6.0e-25	107	COG3166	Tfp pilus assembly protein PilN	206
643874105	215	33.33	6	215	8	208	5.0e-41	160	COG3167	Tfp pilus assembly protein PilO	211
643874106	181	35.26	2	172	3	169	2.0e-36	145	COG3168	Tfp pilus assembly protein PilP	170
643874107	702	32.71	19	698	16	707	1.0e-94	341	COG4796	Type II secretory pathway, component HofQ	709
643874108	350	40.29	80	350	33	298	1.0e-69	257	COG2813	16S rRNA G1207 methylase RsmC	300
643874109	404	50.12	1	404	3	389	0.0e+00	468	COG0448	ADP-glucose pyrophosphorylase	393
643874110	482	40.12	1	480	1	480	3.0e-125	442	COG0297	Glycogen synthase	487
643874114	447	44.29	6	440	3	432	3.0e-124	438	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
643874115	326	34.25	1	323	11	305	5.0e-57	214	COG2017	Galactose mutarotase or related enzyme	308
643874116	384	53.75	1	383	3	388	0.0e+00	467	COG0153	Galactokinase	390
643874117	345	57.02	7	344	1	338	5.0e-117	414	COG1085	Galactose-1-phosphate uridylyltransferase	338
643874118	337	47.18	1	335	1	329	0.0e+00	502	COG1087	UDP-glucose 4-epimerase	329
643874119	337	41.21	2	330	1	330	1.0e-86	313	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643874120	333	81.08	1	333	4	336	0.0e+00	464	COG4211	ABC-type glucose/galactose transport system, permease component	336
643874121	506	48.5	8	503	3	498	0.0e+00	645	COG1129	ABC-type sugar transport system, ATPase component	500
643874122	329	30.21	1	329	11	316	5.0e-40	158	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
643874123	135	44.64	10	121	11	122	5.0e-29	120	COG0838	NADH:ubiquinone oxidoreductase subunit 3 (chain A)	123
643874124	223	55.28	17	213	1	194	6.0e-69	254	COG0377	NADH:ubiquinone oxidoreductase 20 kD subunit (chhain B) or related Fe-S oxidoreductase	194
643874125	603	54.64	205	603	1	398	0.0e+00	586	COG0649	NADH:ubiquinone oxidoreductase 49 kD subunit (chain D)	398
643874126	166	49.03	11	165	2	156	7.0e-58	216	COG1905	NADH:ubiquinone oxidoreductase 24 kD subunit (chain E)	160
643874127	444	57	10	422	12	421	0.0e+00	627	COG1894	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit (chain F)	424
643874128	908	35.75	1	782	1	692	0.0e+00	621	COG1034	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)	693
643874129	324	54.86	10	321	11	329	4.0e-99	354	COG1005	NADH:ubiquinone oxidoreductase subunit 1 (chain H)	332
643874130	180	46.3	12	172	14	170	5.0e-44	170	COG1143	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)	172
643874131	175	39.75	1	159	4	164	6.0e-23	100	COG0839	NADH:ubiquinone oxidoreductase subunit 6 (chain J)	166
643874132	102	53.54	4	102	2	100	3.0e-23	100	COG0713	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)	100
643874133	612	44.91	4	608	1	606	2.0e-117	416	COG1009	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit	606
643874134	506	50.92	1	487	4	475	0.0e+00	491	COG1008	NADH:ubiquinone oxidoreductase subunit 4 (chain M)	497
643874135	489	42.3	4	488	1	474	1.0e-88	321	COG1007	NADH:ubiquinone oxidoreductase subunit 2 (chain N)	475
643874136	182	40.11	2	178	8	184	1.0e-35	142	COG2188	DNA-binding transcriptional regulator, GntR family	236
643874137	385	65.19	1	385	1	384	0.0e+00	586	COG1979	Alcohol dehydrogenase YqhD, Fe-dependent ADH family	384
643874138	442	40.4	1	441	1	439	0.0e+00	505	COG1486	Alpha-galactosidase/6-phospho-beta-glucosidase, family 4 of glycosyl hydrolase	442
643874139	527	34.1	1	424	8	390	3.0e-58	220	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
643874140	498	40.2	5	487	3	492	1.0e-113	403	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	492
643874141	425	43.18	1	398	21	416	2.0e-109	389	COG0513	Superfamily II DNA and RNA helicase	513
643874143	421	79.95	1	419	4	421	0.0e+00	732	COG1158	Transcription termination factor Rho	422
643874146	542	38.4	1	261	9	269	1.0e-51	198	COG3267	Type II secretory pathway, component ExeA (predicted ATPase)	269
643874147	410	34.51	1	391	23	405	2.0e-76	279	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
643874148	162	41.03	1	151	1	154	5.0e-27	114	COG0801	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	160
643874149	116	43.97	1	115	2	117	1.0e-27	114	COG1539	Dihydroneopterin aldolase	121
643874150	203	48	1	193	1	200	4.0e-50	191	COG0344	Phospholipid biosynthesis protein PlsY, probable glycerol-3-phosphate acyltransferase	200
643874151	339	56.93	1	334	1	337	3.0e-130	458	COG0533	tRNA A37 threonylcarbamoyltransferase TsaD	342
643874152	71	59.7	1	67	1	67	4.0e-08	49.5	COG0828	Ribosomal protein S21	67
643874153	582	38.44	4	582	1	568	2.0e-129	456	COG0358	DNA primase (bacterial type)	568
643874154	617	49.3	260	616	1	342	1.0e-100	360	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
643874161	913	35.06	419	908	68	562	1.0e-97	351	COG5519	Uncharcterized protein, DUF927 family	562
643874162	237	45.63	11	113	4	101	6.0e-19	88	COG3561	Phage anti-repressor protein	110
643874163	58	28.07	2	58	11	67	2.0e-06	44.1	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
643874165	433	16.93	115	419	20	308	1.0e-05	45	COG0582	Integrase	309
643874166	513	30.12	31	275	1	246	1.0e-32	134	COG4584	Transposase	278
643874167	251	33.74	1	241	6	248	2.0e-43	169	COG1484	DNA replication protein DnaC	254
643874172	246	29.17	22	237	10	215	5.0e-31	128	COG1285	Uncharacterized membrane protein YhiD, involved in acid resistance	221
643874173	397	66.41	1	395	1	396	0.0e+00	615	COG3007	Trans-2-enoyl-CoA reductase	398
643874174	484	37.09	2	453	1	454	3.0e-84	305	COG2027	D-alanyl-D-alanine carboxypeptidase	470
643874175	404	37.28	8	403	1	393	2.0e-101	363	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
643874176	205	35.35	6	201	1	192	5.0e-36	144	COG1896	5'-deoxynucleotidase YfbR and related HD superfamily hydrolases	193
643874177	184	26.47	1	183	1	204	2.0e-14	72.7	COG0778	Nitroreductase	207
643874178	616	37.58	270	563	4	297	5.0e-59	222	COG0616	Periplasmic serine protease, ClpP class	317
643874179	335	35.31	1	331	18	351	3.0e-81	295	COG0252	L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D	351
643874180	127	58.4	2	124	7	131	5.0e-51	193	COG0229	Peptide methionine sulfoxide reductase MsrB	140
643874181	695	48.02	5	660	10	674	0.0e+00	716	COG1523	Pullulanase/glycogen debranching enzyme	697
643874182	727	51.92	104	723	14	627	0.0e+00	719	COG0296	1,4-alpha-glucan branching enzyme	628
643874183	730	40.04	167	725	1	517	0.0e+00	474	COG1640	4-alpha-glucanotransferase	520
643874184	336	65.47	7	336	1	332	0.0e+00	472	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	335
643874185	294	35.79	29	294	27	285	6.0e-54	204	COG0676	D-hexose-6-phosphate mutarotase	287
643874186	353	46.79	18	343	12	324	3.0e-111	395	COG0379	Quinolinate synthase	324
643874195	262	35	20	259	33	257	2.0e-32	133	COG1729	Periplasmic TolA-binding protein (function unknown)	262
643874196	171	32.02	8	171	10	187	1.0e-29	122	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
643874197	431	43.72	5	430	1	425	3.0e-97	349	COG0823	Periplasmic component of the Tol biopolymer transport system	425
643874198	353	27.2	9	342	15	373	8.0e-14	71.7	COG3064	Membrane protein involved in colicin uptake	387
643874199	145	42.22	4	138	5	132	1.0e-27	115	COG0848	Biopolymer transport protein ExbD	137
643874200	228	46.3	11	226	1	216	2.0e-51	195	COG0811	Biopolymer transport protein ExbB/TolQ	216
643874201	137	40.62	1	128	1	127	7.0e-31	126	COG0824	Acyl-CoA thioesterase FadM	137
643874202	37	72.73	1	33	1	33	1.0e-08	51.2	COG4890	Predicted outer membrane lipoprotein	37
643874203	379	46.3	1	374	1	346	5.0e-90	324	COG1294	Cytochrome bd-type quinol oxidase, subunit 2	346
643874205	337	68.98	4	335	1	332	0.0e+00	538	COG2255	Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit	332
643874206	206	47.12	1	206	1	201	2.0e-64	238	COG0632	Holliday junction resolvasome RuvABC DNA-binding subunit	201
643874207	173	59.49	5	161	1	158	2.0e-56	211	COG0817	Holliday junction resolvasome RuvABC endonuclease subunit	160
643874208	247	59.92	1	240	1	241	6.0e-95	340	COG0217	Transcriptional and/or translational regulatory protein YebC/TACO1	241
643874209	588	61.08	1	585	1	585	0.0e+00	934	COG0173	Aspartyl-tRNA synthetase	585
643874210	84	47.3	1	73	8	80	2.0e-16	77.8	COG2331	Predicted nucleic acid-binding protein, contains Zn-ribbon domain	82
643874211	476	49.89	1	440	1	436	0.0e+00	559	COG0621	tRNA A37 methylthiotransferase MiaB	437
643874212	348	54.18	10	332	16	334	4.0e-117	415	COG1702	Phosphate starvation-inducible protein PhoH, predicted ATPase	348
643874213	155	51.63	3	153	1	153	2.0e-43	168	COG0319	ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme	153
643874214	292	60.2	1	292	1	291	2.0e-103	368	COG4535	Mg2+ and Co2+ transporter CorC, contains CBS pair and CorC-HlyC domains	293
643874215	517	34.18	21	516	21	517	1.0e-94	340	COG0815	Apolipoprotein N-acyltransferase	518
643874216	226	28.31	2	219	1	212	2.0e-25	109	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
643874218	338	36.84	17	331	11	317	2.0e-80	292	COG0042	tRNA-dihydrouridine synthase	323
643874220	358	52.21	1	357	2	358	4.0e-120	425	COG0787	Alanine racemase	360
643874221	464	51.7	17	457	1	435	0.0e+00	549	COG0305	Replicative DNA helicase	435
643874227	64	65.52	1	58	1	58	3.0e-19	86.5	COG1551	sRNA-binding carbon storage regulator CsrA	73
643874228	874	55.34	1	874	4	879	0.0e+00	1169	COG0013	Alanyl-tRNA synthetase	879
643874229	151	42.36	12	150	22	165	1.0e-25	109	COG2137	SOS response regulatory protein OraA/RecX, interacts with RecA	174
643874230	360	64.56	1	281	3	279	3.0e-88	318	COG0468	RecA/RadA recombinase	279
643874231	161	57.14	4	157	5	157	3.0e-47	181	COG1546	Nicotinamide mononucleotide (NMN) deamidase PncC	162
643874232	865	53.32	10	857	2	843	0.0e+00	995	COG0249	DNA mismatch repair ATPase MutS	843
643874233	324	42.77	8	321	25	342	4.0e-76	278	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
643874234	378	29.35	90	378	4	267	4.0e-31	129	COG0739	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain	277
643874235	208	54.5	9	206	6	205	7.0e-64	236	COG2518	Protein-L-isoaspartate O-methyltransferase	209
643874236	248	55.78	1	243	1	250	5.0e-89	320	COG0496	Broad specificity polyphosphatase and 5'/3'-nucleotidase SurE	252
643874237	353	29.7	3	342	6	399	4.0e-70	258	COG0585	tRNA(Glu) U13 pseudouridine synthase TruD	406
643874238	160	61.64	2	160	1	159	1.0e-61	228	COG0245	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	159
643874239	227	46.93	1	223	2	228	3.0e-68	251	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	230
643874240	105	44.83	1	87	24	110	3.0e-15	73.8	COG2919	Cell division protein FtsB	117
643874241	433	67.13	1	432	1	423	0.0e+00	622	COG0148	Enolase	423
643874242	545	65.38	3	543	1	533	0.0e+00	899	COG0504	CTP synthase (UTP-ammonia lyase)	533
643874244	743	55.39	58	743	55	701	0.0e+00	835	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	701
643874245	440	33.87	15	433	3	432	4.0e-96	345	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
643874246	908	35.79	254	523	78	335	3.0e-43	170	COG0642	Signal transduction histidine kinase	336
643874248	203	27.18	1	203	1	206	2.0e-22	98.8	COG1280	Threonine/homoserine/homoserine lactone efflux protein	208
643874249	462	33.11	10	452	1	453	2.0e-83	303	COG1167	DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain	459
643874250	79	65.67	1	67	1	67	8.0e-19	85.4	COG3089	Uncharacterized conserved protein YheU, UPF0270 family	72
643874251	212	34.95	8	212	12	214	6.0e-39	154	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
643874252	405	53.45	1	405	2	402	0.0e+00	527	COG4992	Acetylornithine/succinyldiaminopimelate/putrescine aminotransferase	404
643874253	192	63.54	1	192	3	190	2.0e-83	301	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
643874254	159	42.68	5	159	2	150	1.0e-36	145	COG3012	Uncharacterized conserved protein YchJ, contains N- and C-terminal SEC-C domains	151
643874256	441	21.79	70	381	56	340	2.0e-08	54.1	COG2814	Predicted arabinose efflux permease, MFS family	394
643874257	161	40.12	5	161	13	174	5.0e-38	150	COG0684	Regulator of RNase E activity RraA	210
643874258	69	46.84	1	65	1	79	2.0e-06	43.9	COG3074	Cell division protein ZapB, interacts with FtsZ	79
643874260	263	57.92	79	261	2	184	6.0e-68	250	COG1045	Serine acetyltransferase	194
643874261	302	37.11	8	297	7	297	9.0e-69	254	COG0053	Divalent metal cation (Fe/Co/Zn/Cd) transporter	304
643874262	282	43.59	1	272	2	267	6.0e-55	207	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
643874263	308	52.26	15	301	5	280	3.0e-73	269	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
643874264	377	51.1	15	375	1	350	4.0e-123	434	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
643874265	366	43.92	6	366	11	363	6.0e-92	331	COG0687	Spermidine/putrescine-binding periplasmic protein	363
643874266	161	50.99	1	148	3	152	3.0e-42	164	COG3045	Periplasmic catabolite regulation protein CreA (function unknown)	165
643874274	858	57.58	5	857	1	783	0.0e+00	972	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
643874275	245	53.44	1	241	1	247	8.0e-82	296	COG1496	Copper oxidase (laccase) domain	249
643874276	326	45.15	10	303	5	289	2.0e-78	286	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
643874277	253	43.37	3	251	2	240	3.0e-64	238	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	254
643874278	153	61.7	9	149	1	141	6.0e-58	216	COG1803	Methylglyoxal synthase	142
643874279	394	87.56	1	394	1	394	0.0e+00	730	COG0050	Translation elongation factor EF-Tu, a GTPase	394
643874280	700	67.09	1	698	1	692	0.0e+00	1020	COG0480	Translation elongation factor EF-G, a GTPase	697
643874281	156	62.84	2	149	1	148	2.0e-55	208	COG0049	Ribosomal protein S7	148
643874282	124	76.42	1	123	7	129	4.0e-49	186	COG0048	Ribosomal protein S12	129
643874283	90	35.42	1	90	1	96	1.0e-12	64.9	COG2168	Sulfur transfer complex TusBCD TusB component, DsrH family	96
643874284	118	48.31	1	118	1	118	1.0e-27	114	COG2923	Sulfur relay (sulfurtransferase) complex TusC component, DsrF/TusC family	118
643874285	130	44.09	4	130	2	126	5.0e-31	126	COG1553	Sulfur relay (sulfurtransferase) complex TusBCD TusD component, DsrE family	126
643874286	128	56.59	1	128	2	130	3.0e-36	143	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
643874287	1434	49.49	20	879	7	808	0.0e+00	896	COG0086	DNA-directed RNA polymerase, beta' subunit/160 kD subunit	808
643874289	121	62.1	1	121	1	124	1.0e-20	91.8	COG0222	Ribosomal protein L7/L12	124
643874290	167	49.08	1	162	1	162	3.0e-36	144	COG0244	Ribosomal protein L10	175
643874291	234	60.53	1	227	1	228	9.0e-81	293	COG0081	Ribosomal protein L1	228
643874292	142	73.05	2	142	1	140	3.0e-52	197	COG0080	Ribosomal protein L11	141
643874293	180	54.29	6	180	3	177	6.0e-57	213	COG0250	Transcription antitermination factor NusG	178
643874294	127	41.1	49	121	1	73	6.0e-09	53.1	COG0690	Preprotein translocase subunit SecE	73
643874296	394	87.82	1	394	1	394	0.0e+00	732	COG0050	Translation elongation factor EF-Tu, a GTPase	394
643874299	315	61.19	9	294	4	283	1.0e-103	369	COG1072	Panthothenate kinase	283
643874300	321	36.82	85	320	1	238	1.0e-59	223	COG0340	Biotin-(acetyl-CoA carboxylase) ligase	238
643874301	346	34.83	8	338	8	291	2.0e-78	286	COG0812	UDP-N-acetylenolpyruvoylglucosamine reductase	291
643874302	457	60.89	1	450	1	448	0.0e+00	621	COG0541	Signal recognition particle GTPase	451
643874303	261	39.08	1	260	2	261	1.0e-42	166	COG4137	ABC-type uncharacterized transport system, permease component	265
643874304	498	55.21	1	498	1	463	0.0e+00	603	COG1282	NAD/NADP transhydrogenase beta subunit	463
643874305	510	64.93	2	366	1	356	2.0e-129	456	COG3288	NAD/NADP transhydrogenase alpha subunit	356
643874307	148	27.78	1	145	12	171	3.0e-17	81.2	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
643874309	546	26.42	6	295	10	300	3.0e-42	167	COG0714	MoxR-like ATPase	329
643874310	479	27.41	29	479	14	436	1.0e-68	254	COG2425	Uncharacterized protein, contains a von Willebrand factor type A (vWA) domain	437
643874312	307	55.38	1	306	1	314	2.0e-114	405	COG0540	Aspartate carbamoyltransferase, catalytic chain	316
643874313	154	53.25	1	153	1	153	4.0e-52	196	COG1781	Aspartate carbamoyltransferase, regulatory subunit	153
643874314	380	18.85	1	376	10	388	2.0e-12	67.2	COG2814	Predicted arabinose efflux permease, MFS family	394
643874315	397	69.42	1	397	1	399	8.0e-118	417	COG4651	Predicted Kef-type K+ transport protein, K+/H+ antiporter domain	408
643874318	149	51.68	1	149	2	148	5.0e-46	176	COG1671	Uncharacterized conserved protein YaiI, UPF0178 family	150
643874319	618	41.55	5	344	5	346	6.0e-76	279	COG0826	Collagenase-like protease, PrtC family	347
643874320	849	39.44	666	844	2	180	2.0e-37	151	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
643874321	167	36.36	7	160	2	157	2.0e-22	98.5	COG3663	G:T/U-mismatch repair DNA glycosylase	169
643874322	545	48.09	1	533	1	523	0.0e+00	489	COG0459	Chaperonin GroEL (HSP60 family)	524
643874323	97	59.79	1	97	1	96	3.0e-27	113	COG0234	Co-chaperonin GroES (HSP10)	96
643874324	170	34.13	1	167	2	148	3.0e-25	108	COG3030	Protein affecting phage T7 exclusion by the F plasmid, UPF0716 family	158
643874325	106	54.37	2	104	1	103	3.0e-32	129	COG1324	Uncharacterized protein involved in tolerance to divalent cations	104
643874326	576	41.51	13	569	5	566	9.0e-125	440	COG4232	Thiol:disulfide interchange protein	569
643874327	98	43.37	11	91	5	87	4.0e-20	89.6	COG2827	Predicted endonuclease, GIY-YIG superfamily	95
643874328	449	43.4	1	446	2	433	2.0e-95	342	COG0733	Na+-dependent transporter, SNF family	439
643874332	861	51.91	4	860	1	814	0.0e+00	1082	COG0495	Leucyl-tRNA synthetase	814
643874333	163	28.83	1	161	1	160	4.0e-22	97.7	COG2980	Outer membrane lipoprotein LptE/RlpB (LPS assembly)	178
643874334	345	29.52	4	332	2	331	9.0e-45	174	COG1466	DNA polymerase III, delta subunit	334
643874335	111	49.06	1	106	1	106	5.0e-33	132	COG0799	Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits	115
643874336	156	52.9	1	155	1	155	2.0e-61	228	COG1576	23S rRNA pseudoU1915 N3-methylase RlmH	155
643874337	628	33.12	6	616	3	593	7.0e-124	437	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
643874338	367	42.78	4	365	2	374	1.0e-80	293	COG0772	Bacterial cell division protein FtsW, lipid II flippase	381
643874339	323	36.16	14	317	32	336	9.0e-63	234	COG2951	Membrane-bound lytic murein transglycosylase B	343
643874340	256	41.45	3	184	2	192	2.0e-41	162	COG0797	Rare lipoprotein A, peptidoglycan hydrolase digesting "naked" glycans, contains C-terminal SPOR domain	233
643874342	413	49.2	37	410	16	387	9.0e-113	400	COG1686	D-alanyl-D-alanine carboxypeptidase	389
643874343	89	55.17	5	89	4	90	2.0e-25	106	COG2921	Putative lipoic acid-binding regulatory protein	90
643874344	225	57.14	1	208	6	215	2.0e-76	279	COG0321	Lipoate-protein ligase B	221
643874345	321	62.46	13	321	1	306	0.0e+00	490	COG0320	Lipoate synthase	306
643874346	227	40.97	1	226	1	223	1.0e-64	239	COG2949	Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin	235
643874347	521	45.11	11	519	33	546	0.0e+00	488	COG3604	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains	550
643874348	930	44.06	666	926	2	256	1.0e-71	265	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
643874351	388	39.04	1	388	1	414	2.0e-127	449	COG1004	UDP-glucose 6-dehydrogenase	414
643874352	87	35.71	5	86	3	84	5.0e-15	72.6	COG4115	Toxin component of the Txe-Axe toxin-antitoxin module, Txe/YoeB family	84
643874353	80	38.55	1	80	3	85	4.0e-11	59.6	COG2161	Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family	86
643874354	100	32.63	1	94	1	94	3.0e-11	60.1	COG3668	Plasmid stabilization system protein ParE	98
643874355	85	20	1	80	3	80	3.0e-07	46.9	COG2161	Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family	86
643874357	89	28.75	1	80	8	86	8.0e-07	45.3	COG4453	Uncharacterized conserved protein, DUF1778 family	95
643874358	82	30.23	4	82	1	86	9.0e-09	51.9	COG2161	Antitoxin component YafN of the YafNO toxin-antitoxin module, PHD/YefM family	86
643874359	96	41.57	1	88	1	89	6.0e-16	75.7	COG2026	mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system	90
643874363	445	44.32	1	443	5	460	8.0e-118	417	COG1109	Phosphomannomutase	464
643874364	334	31.98	1	334	1	313	8.0e-55	207	COG0451	Nucleoside-diphosphate-sugar epimerase	314
643874368	293	20.83	1	289	2	296	2.0e-20	93.7	COG1216	Glycosyltransferase, GT2 family	305
643874369	289	20.65	4	287	3	305	8.0e-16	77.9	COG1216	Glycosyltransferase, GT2 family	305
643874370	365	20.98	11	365	18	374	7.0e-23	101	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
643874372	423	21.09	3	423	9	412	8.0e-14	72.1	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
643874373	351	26.81	7	313	8	315	1.0e-31	131	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
643874374	719	27.53	15	456	9	457	1.0e-60	228	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
643874375	145	37.41	7	144	5	139	2.0e-29	121	COG0394	Protein-tyrosine-phosphatase	139
643874376	415	45.75	75	321	1	239	1.0e-53	204	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
643874379	268	44.57	1	258	6	267	2.0e-69	256	COG3384	Aromatic ring-opening dioxygenase, catalytic subunit, LigB family	268
643874380	81	34.29	12	81	11	80	2.0e-07	47	COG5302	Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid	80
643874382	279	40.58	3	278	6	313	9.0e-69	253	COG0627	S-formylglutathione hydrolase FrmB	316
643874383	374	72.63	4	372	1	366	0.0e+00	573	COG1062	Zn-dependent alcohol dehydrogenase	366
643874384	292	33.22	4	292	3	295	9.0e-46	177	COG0583	DNA-binding transcriptional regulator, LysR family	297
643874385	151	22.22	15	104	4	93	4.0e-06	44.6	COG2944	DNA-binding transcriptional regulator YiaG, XRE-type HTH domain	104
643874386	198	41.33	4	194	11	203	2.0e-43	168	COG3647	Uncharacterized membrane protein YjdF	205
643874388	127	41.94	2	125	1	123	2.0e-18	84.5	COG2363	Uncharacterized membrane protein YgdD, TMEM256/DUF423 family	124
643874389	473	56.37	4	466	2	461	0.0e+00	659	COG1904	Glucuronate isomerase	463
643874390	491	49.58	22	491	9	473	0.0e+00	535	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
643874391	393	62.09	1	393	1	361	0.0e+00	548	COG1312	D-mannonate dehydratase	362
643874392	433	22.51	12	432	17	441	5.0e-27	116	COG2271	Sugar phosphate permease	448
643874393	788	32.99	4	779	7	764	0.0e+00	611	COG1501	Alpha-glucosidase, glycosyl hydrolase family GH31	772
643874394	245	35.86	3	227	6	236	2.0e-42	166	COG2186	DNA-binding transcriptional regulator, FadR family	241
643874396	473	42.3	2	457	4	463	1.0e-109	390	COG2211	Na+/melibiose symporter or related transporter	467
643874400	451	42.86	6	448	8	454	3.0e-106	379	COG2211	Na+/melibiose symporter or related transporter	467
643874401	604	30.15	1	593	1	598	1.0e-107	383	COG3250	Beta-galactosidase/beta-glucuronidase	808
643874402	308	32.11	1	295	1	293	5.0e-29	121	COG0583	DNA-binding transcriptional regulator, LysR family	297
643874403	600	32.9	5	447	7	467	9.0e-83	301	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
643874404	1200	47.31	1	459	1	460	0.0e+00	541	COG4770	Acetyl/propionyl-CoA carboxylase, alpha subunit	645
643874405	212	36.23	11	211	44	247	1.0e-47	183	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	264
643874406	240	26.05	2	209	43	250	2.0e-25	109	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	264
643874407	267	43.22	3	238	1	220	3.0e-65	242	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
643874408	276	30.27	11	271	8	258	1.0e-30	126	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	258
643874409	358	23.81	9	317	7	311	1.0e-23	104	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	335
643874411	230	34.36	9	202	1	193	8.0e-38	150	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
643874416	192	23.78	8	191	12	195	8.0e-12	63.5	COG1309	DNA-binding transcriptional regulator, AcrR family	201
643874417	373	25.13	1	357	2	366	1.0e-29	124	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
643874418	1024	38.08	2	1001	1	1006	0.0e+00	852	COG0841	Multidrug efflux pump subunit AcrB	1009
643874419	473	56.76	1	448	4	451	0.0e+00	540	COG1115	Na+/alanine symporter	452
643874420	1025	41.41	41	917	6	807	0.0e+00	654	COG3250	Beta-galactosidase/beta-glucuronidase	808
643874421	967	48.8	1	954	11	953	0.0e+00	922	COG1391	Glutamine synthetase adenylyltransferase	963
643874422	143	34.88	15	143	19	145	2.0e-18	85	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
643874423	247	39.84	1	245	4	254	3.0e-70	258	COG1121	ABC-type Mn2+/Zn2+ transport system, ATPase component	254
643874424	292	36.69	5	281	1	273	6.0e-34	137	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	274
643874425	314	35.24	1	314	7	303	5.0e-71	261	COG0803	ABC-type Zn uptake system ZnuABC, Zn-binding component ZnuA	303
643874426	280	41.22	6	278	5	273	5.0e-61	227	COG1741	Redox-sensitive bicupin YhaK, pirin superfamily	276
643874427	115	54.95	3	113	2	112	1.0e-25	108	COG3076	Regulator of RNase E activity RraB	135
643874428	169	64.2	1	162	1	161	8.0e-71	259	COG1854	S-ribosylhomocysteine lyase LuxS, autoinducer biosynthesis	161
643874429	193	43.37	1	191	5	196	6.0e-54	203	COG4764	Uncharacterized protein	197
643874430	112	76.79	1	112	1	112	4.0e-40	156	COG0347	Nitrogen regulatory protein PII	112
643874431	130	61.54	1	130	1	130	6.0e-45	173	COG0103	Ribosomal protein S9	130
643874432	142	63.64	1	142	1	143	1.0e-55	208	COG0102	Ribosomal protein L13	148
643874433	132	30.53	1	130	6	135	7.0e-12	63.1	COG3105	Uncharacterized membrane-anchored protein YhcB, DUF1043 family	138
643874434	454	47.65	8	366	4	347	3.0e-74	272	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
643874435	366	38.68	12	356	4	340	9.0e-64	237	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
643874436	419	66.03	1	419	1	421	0.0e+00	651	COG0766	UDP-N-acetylglucosamine enolpyruvyl transferase	421
643874437	84	61.25	1	80	1	80	1.0e-26	111	COG5007	Acid stress-induced BolA-like protein IbaG/YrbA, predicted regulator of iron metabolism	80
643874438	86	30	3	79	16	95	3.0e-07	46.8	COG3113	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, MlaB component, contains STAS domain	99
643874439	212	42.29	1	201	3	202	3.0e-48	185	COG2854	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, periplasmic MlaC component	202
643874441	259	46.72	1	259	7	264	2.0e-67	249	COG0767	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, permease component MlaE	267
643874442	262	57.81	1	255	4	259	1.0e-100	359	COG1127	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, ATPase component MlaF	263
643874443	324	58.71	7	206	1	201	1.0e-70	260	COG0794	D-arabinose 5-phosphate isomerase GutQ	202
643874444	185	58.08	16	182	1	167	2.0e-58	218	COG1778	 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases	170
643874445	187	25	1	183	2	182	3.0e-20	91.9	COG3117	Lipopolysaccharide export system protein LptC	188
643874446	172	36.36	8	171	10	173	4.0e-31	127	COG1934	Lipopolysaccharide export system protein LptA	173
643874447	241	68.6	1	241	2	243	2.0e-109	388	COG1137	ABC-type lipopolysaccharide export system, ATPase component	243
643874448	484	49.59	1	484	1	444	0.0e+00	497	COG1508	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog	444
643874449	95	46.39	1	95	1	97	5.0e-23	99.2	COG1544	Ribosome-associated translation inhibitor RaiA	110
643874450	148	30.56	2	143	1	144	2.0e-25	108	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
643874451	288	55.4	1	283	1	285	5.0e-102	364	COG1660	RNase adaptor protein for sRNA GlmZ degradation, contains a P-loop ATPase domain	286
643874452	91	40.23	4	90	2	88	8.0e-18	82.2	COG1925	Phosphotransferase system, HPr and related phosphotransfer proteins	88
643874453	295	30.95	2	290	1	290	4.0e-32	132	COG0583	DNA-binding transcriptional regulator, LysR family	297
643874454	757	60.42	427	757	1	329	2.0e-126	447	COG0620	Methionine synthase II (cobalamin-independent)	330
643874455	258	35.04	1	258	6	279	1.0e-51	196	COG0682	Prolipoprotein diacylglyceryltransferase	287
643874456	167	27.71	2	160	6	167	3.0e-13	68.1	COG4970	Tfp pilus assembly protein FimT	181
643874461	134	32.59	6	134	6	139	3.0e-19	87.4	COG4968	Tfp pilus assembly protein PilE	139
643874462	310	65.42	1	295	2	294	6.0e-126	443	COG0761	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH	294
643874463	164	39.52	1	164	2	163	5.0e-34	137	COG0597	Lipoprotein signal peptidase	167
643874464	938	51.63	2	932	1	933	0.0e+00	1277	COG0060	Isoleucyl-tRNA synthetase	933
643874465	317	49.51	1	305	1	303	1.0e-99	356	COG0196	FAD synthase	304
643874466	521	42.86	1	519	5	518	4.0e-110	391	COG0728	Peptidoglycan biosynthesis protein MviN/MurJ, putative lipid II flippase	518
643874467	87	60.92	1	87	1	87	4.0e-12	63	COG0268	Ribosomal protein S20	88
643874468	98	38.78	1	97	3	100	2.0e-09	54.4	COG0640	DNA-binding transcriptional regulator, ArsR family	110
643874469	298	23.88	4	287	1	285	4.0e-26	112	COG0583	DNA-binding transcriptional regulator, LysR family	297
643874470	398	61.46	1	384	4	387	4.0e-123	435	COG3004	Na+/H+ antiporter NhaA	390
643874471	283	38.87	1	283	3	268	1.0e-86	312	COG0207	Thymidylate synthase	268
643874472	754	44.05	1	750	1	752	0.0e+00	752	COG3605	Signal transduction protein containing GAF and PtsI domains	756
643874473	174	23.13	13	157	17	155	1.0e-10	59.6	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
643874474	219	58.53	3	219	12	228	3.0e-75	274	COG3066	DNA mismatch repair protein MutH	229
643874476	115	69.64	3	114	4	115	3.0e-42	163	COG0335	Ribosomal protein L19	115
643874477	249	56.43	1	240	1	239	1.0e-105	376	COG0336	tRNA G37 N-methylase TrmD	240
643874478	173	47.06	5	173	8	172	2.0e-49	188	COG0806	Ribosomal 30S subunit maturation factor RimM, required for 16S rRNA processing	174
643874479	82	60.98	1	82	1	81	6.0e-27	112	COG0228	Ribosomal protein S16	87
643874485	274	44.27	15	272	8	266	1.0e-67	250	COG0796	Glutamate racemase	269
643874486	326	30.91	1	318	2	326	6.0e-55	208	COG2334	Ser/Thr protein kinase RdoA involved in Cpx stress response, MazF antagonist	331
643874487	88	60.23	1	88	1	88	1.0e-26	111	COG3084	Uncharacterized protein YihD, DUF1040 family	88
643874488	343	22.01	8	311	15	288	1.0e-21	97.7	COG1562	Phytoene/squalene synthetase	288
643874489	489	57.67	1	489	1	477	0.0e+00	674	COG0043	3-polyprenyl-4-hydroxybenzoate decarboxylase	477
643874490	232	30.65	24	222	29	219	5.0e-36	144	COG0543	NAD(P)H-flavin reductase	252
643874491	84	50	1	82	10	91	2.0e-15	73.9	COG2960	Uncharacterized conserved protein YqiC, BMFP domain	103
643874492	604	56.81	11	602	7	588	0.0e+00	729	COG0514	Superfamily II DNA helicase RecQ	590
643874494	292	53.26	2	292	3	292	2.0e-74	272	COG2962	Uncharacterized membrane protein RarD, contains two EamA domains	293
643874495	101	49	1	100	1	100	3.0e-27	113	COG1440	Phosphotransferase system cellobiose-specific component IIB	102
643874496	434	43.45	3	431	2	432	1.0e-103	370	COG1455	Phosphotransferase system cellobiose-specific component IIC	432
643874497	111	44	9	108	5	104	3.0e-20	90.2	COG1447	Phosphotransferase system cellobiose-specific component IIA	105
643874498	467	47.76	1	466	1	456	0.0e+00	559	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
643874499	86	48.15	6	86	5	85	1.0e-09	54.8	COG4095	Uncharacterized conserved protein, contains PQ loop repeat	89
643874500	340	40.06	2	331	1	331	4.0e-86	311	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643874501	1036	49.9	1	1034	1	1024	0.0e+00	1178	COG3696	Cu/Ag efflux pump CusA	1027
643874502	457	31.89	136	436	41	354	3.0e-17	83.2	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
643874503	123	28.16	11	113	7	100	1.0e-07	48.9	COG5569	Periplasmic Cu and Ag efflux protein CusF	108
643874505	279	47.5	1	278	1	274	3.0e-93	334	COG0648	Endonuclease IV	280
643874506	101	49	1	100	1	100	2.0e-29	120	COG1440	Phosphotransferase system cellobiose-specific component IIB	102
643874507	447	63.62	1	447	1	447	0.0e+00	640	COG1726	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA	447
643874508	411	67.73	3	408	2	400	0.0e+00	497	COG1805	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB	400
643874509	257	50.38	1	257	1	264	4.0e-89	321	COG2869	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC	264
643874510	215	72.46	1	207	1	207	4.0e-85	307	COG1347	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD	208
643874511	198	80.3	1	198	1	198	2.0e-78	285	COG2209	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE	198
643874512	408	77.21	1	408	3	410	0.0e+00	725	COG2871	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF	410
643874513	71	47.89	1	71	1	71	2.0e-18	83.8	COG2991	Uncharacterized protein	77
643874515	679	57.94	1	679	8	682	0.0e+00	932	COG0339	Zn-dependent oligopeptidase	683
643874516	597	32.35	167	554	5	383	8.0e-59	221	COG0006	Xaa-Pro aminopeptidase	384
643874517	450	23.39	18	433	56	430	5.0e-42	165	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
643874519	504	48.06	4	476	2	486	2.0e-91	329	COG0591	Na+/proline symporter	493
643874520	473	66.74	2	470	1	468	0.0e+00	728	COG1027	Aspartate ammonia-lyase	471
643874521	292	37.59	10	290	3	281	4.0e-62	231	COG0421	Spermidine synthase	282
643874523	220	45.41	1	204	1	207	5.0e-58	217	COG0288	Carbonic anhydrase	207
643874524	284	39.29	10	284	62	333	1.0e-67	249	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
643874525	322	32.89	21	321	1	296	2.0e-53	202	COG2177	Cell division protein FtsX	297
643874526	226	60.09	1	218	1	218	3.0e-84	304	COG2884	ABC-type ATPase involved in cell division	223
643874527	435	54.71	99	431	1	340	5.0e-113	401	COG0552	Signal recognition particle GTPase	340
643874528	204	48.39	20	200	1	186	5.0e-56	210	COG0742	16S rRNA G966 N2-methylase RsmD	187
643874530	686	55.86	1	647	1	644	0.0e+00	855	COG4776	Exoribonuclease II	645
643874531	472	32	189	472	35	329	7.0e-35	141	COG0642	Signal transduction histidine kinase	336
643874532	241	45.69	7	236	1	228	3.0e-59	221	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
643874534	691	31.69	14	682	30	750	7.0e-111	395	COG1444	tRNA(Met) C34 N-acetyltransferase TmcA	758
643874535	185	53.98	5	179	7	174	1.0e-51	195	COG0241	Histidinol phosphatase or a related phosphatase	181
643874537	254	35.98	1	234	3	239	4.0e-44	171	COG2186	DNA-binding transcriptional regulator, FadR family	241
643874538	430	26.92	9	412	26	433	5.0e-36	145	COG2271	Sugar phosphate permease	448
643874539	470	56.25	4	467	2	463	0.0e+00	639	COG1904	Glucuronate isomerase	463
643874540	487	31.77	1	484	1	471	4.0e-109	388	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
643874541	495	53.16	103	495	1	381	0.0e+00	520	COG2721	Altronate dehydratase	381
643874543	163	48.68	13	158	2	153	3.0e-46	177	COG1683	Uncharacterized conserved protein YbbK, DUF523 family	156
643874544	367	30.74	90	342	9	252	7.0e-37	148	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
643874548	166	47.95	22	88	26	98	7.0e-13	66.9	COG4104	Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, incolved in TypeVI secretion	98
643874550	355	28	129	315	2	199	2.0e-19	90.1	COG2856	Zn-dependent peptidase ImmA, M78 family	213
643874553	259	27.69	1	259	5	252	5.0e-08	51.9	COG0730	Uncharacterized membrane protein YfcA	258
643874556	371	35.03	8	370	10	378	3.0e-51	196	COG0006	Xaa-Pro aminopeptidase	384
643874559	160	35.26	1	154	1	154	9.0e-35	139	COG2731	Beta-galactosidase, beta subunit	154
643874560	264	40.41	12	255	1	245	4.0e-65	241	COG1414	DNA-binding transcriptional regulator, IclR family	246
643874561	311	31.21	5	303	1	297	6.0e-44	171	COG0524	Sugar or nucleoside kinase, ribokinase family	311
643874562	207	46.89	1	207	3	210	5.0e-61	227	COG0800	2-keto-3-deoxy-6-phosphogluconate aldolase	211
643874563	278	66.55	1	278	1	278	5.0e-129	453	COG3717	5-keto 4-deoxyuronate isomerase	278
643874564	253	36.47	6	251	1	251	5.0e-47	181	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
643874565	302	29.09	1	301	1	330	4.0e-38	151	COG0673	Predicted dehydrogenase	342
643874566	294	23.33	24	287	1	255	1.0e-24	106	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
643874567	301	45.36	1	275	11	301	3.0e-64	238	COG0714	MoxR-like ATPase	329
643874568	324	20.75	18	322	3	301	5.0e-18	85.6	COG1721	Uncharacterized conserved protein, DUF58 family, contains vWF domain	416
643874569	666	23.95	254	482	26	259	3.0e-18	87.4	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
643874570	119	66.37	1	113	5	116	2.0e-39	154	COG3169	Uncharacterized conserved protein, DUF486 family	116
643874571	472	38.75	4	472	29	479	3.0e-95	342	COG1785	Alkaline phosphatase	482
643874572	457	39.91	22	457	56	479	7.0e-91	328	COG1785	Alkaline phosphatase	482
643874574	506	58.16	15	497	1	490	0.0e+00	616	COG0606	Predicted ATPase with chaperone activity	490
643874575	298	18.15	35	298	3	250	9.0e-15	74.4	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
643874576	320	36.39	4	318	11	325	8.0e-76	277	COG4977	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain	328
643874577	251	31.1	1	251	1	252	7.0e-55	207	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
643874578	290	55.71	9	287	6	285	3.0e-112	398	COG3623	L-ribulose-5-phosphate 3-epimerase UlaE	287
643874579	274	28.1	1	273	1	262	7.0e-47	181	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
643874580	355	23.39	35	329	4	255	4.0e-36	145	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
643874581	588	48.74	1	465	1	477	0.0e+00	492	COG3037	Ascorbate-specific PTS system EIIC-type component UlaA	481
643874582	159	25.66	5	151	3	147	9.0e-24	103	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
643874583	232	37.93	1	231	4	219	4.0e-54	204	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
643874584	214	51.39	1	214	1	216	3.0e-69	255	COG0269	3-keto-L-gulonate-6-phosphate decarboxylase	217
643874585	317	38.34	5	313	1	238	4.0e-63	235	COG0176	Transaldolase	239
643874586	666	63.2	6	666	7	663	0.0e+00	1053	COG0021	Transketolase	663
643874591	792	22.4	6	667	1	674	4.0e-26	113	COG3209	Uncharacterized conserved protein RhaS, contains 28 RHS repeats	796
643874597	150	33.79	1	144	3	145	3.0e-19	88	COG4103	Uncharacterized conserved protein, tellurite resistance protein B (TerB) family	148
643874598	316	38.66	5	315	9	319	4.0e-79	288	COG2390	DNA-binding transcriptional regulator LsrR, DeoR family	321
643874599	467	33.99	3	452	12	461	1.0e-106	380	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
643874600	489	42.97	1	482	5	495	7.0e-125	441	COG1070	Sugar (pentulose or hexulose) kinase	502
643874601	430	19.95	42	401	43	397	2.0e-08	54.5	COG2223	Nitrate/nitrite transporter NarK	417
643874602	317	38.34	5	313	1	238	2.0e-63	236	COG0176	Transaldolase	239
643874603	666	62.08	6	665	7	662	0.0e+00	1056	COG0021	Transketolase	663
643874604	175	33.74	12	171	1	162	2.0e-33	135	COG4067	Uncharacterized conserved protein	162
643874605	549	52.18	1	544	2	549	0.0e+00	623	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
643874606	88	54.05	1	74	1	74	2.0e-16	77.3	COG3978	Acetolactate synthase small subunit, contains ACT domain	86
643874607	307	41.44	6	295	2	284	8.0e-72	264	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
643874608	616	55.27	1	614	8	575	0.0e+00	798	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
643874609	511	53.45	4	346	1	347	4.0e-121	428	COG1171	Threonine dehydratase	347
643874612	317	23.41	20	317	2	296	4.0e-24	105	COG0583	DNA-binding transcriptional regulator, LysR family	297
643874614	342	38.01	2	342	1	332	4.0e-78	285	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
643874615	468	46.9	4	467	3	456	0.0e+00	582	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
643874616	109	41.84	1	98	3	100	5.0e-22	96	COG1447	Phosphotransferase system cellobiose-specific component IIA	105
643874617	434	43.65	3	428	2	430	9.0e-104	370	COG1455	Phosphotransferase system cellobiose-specific component IIC	432
643874618	101	48	1	100	1	100	1.0e-27	114	COG1440	Phosphotransferase system cellobiose-specific component IIB	102
643874619	469	46.5	6	467	1	454	0.0e+00	526	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
643874620	465	26.44	94	450	1	382	7.0e-47	181	COG1263	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific	393
643874621	532	36.74	31	526	2	485	4.0e-98	352	COG2272	Carboxylesterase type B	491
643874622	228	35.5	1	196	1	198	7.0e-45	173	COG0518	GMP synthase - Glutamine amidotransferase domain	198
643874623	155	56.77	1	155	1	154	2.0e-47	181	COG2193	Bacterioferritin (cytochrome b1)	157
643874624	154	56.49	1	154	1	154	3.0e-44	170	COG2193	Bacterioferritin (cytochrome b1)	157
643874625	65	44.26	1	61	1	61	3.0e-09	53.8	COG2906	Bacterioferritin-associated ferredoxin	63
643874627	1046	29.81	289	694	12	424	1.0e-65	245	COG1061	Superfamily II DNA or RNA helicase	442
643874629	432	32.64	37	413	5	385	4.0e-55	209	COG3550	Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module	392
643874630	430	39.78	7	430	1	449	5.0e-119	421	COG1797	Cobyrinic acid a,c-diamide synthase	451
643874631	496	54.4	6	489	3	486	0.0e+00	618	COG1492	Cobyric acid synthase	486
643874632	94	57.78	1	90	3	92	2.0e-24	103	COG3636	DNA-binding prophage protein	100
643874633	309	60.47	1	301	2	299	3.0e-103	368	COG4973	Site-specific recombinase XerC	299
643874634	228	33.65	13	221	9	214	1.0e-30	126	COG3159	Uncharacterized conserved protein YigA, DUF484 family	218
643874635	276	55.11	3	276	1	272	3.0e-100	358	COG0253	Diaminopimelate epimerase	272
643874636	416	47.73	2	391	1	394	1.0e-120	427	COG0019	Diaminopimelate decarboxylase	394
643874637	104	54.29	1	103	1	105	1.0e-29	121	COG1965	Iron-binding protein CyaY, frataxin homolog	106
643874638	94	68.89	3	92	5	94	9.0e-41	158	COG3526	Predicted selenoprotein, Rdx family	99
643874640	830	50.54	1	819	1	830	0.0e+00	896	COG3072	Adenylate cyclase	853
643874641	308	62.42	1	306	1	306	1.0e-120	426	COG0181	Porphobilinogen deaminase	307
643874642	241	35.84	1	225	2	227	5.0e-35	141	COG1587	Uroporphyrinogen-III synthase	248
643874643	356	33.43	3	348	9	358	2.0e-50	193	COG2959	Uncharacterized conserved protein HemX (no evidence of involvement in heme biosynthesis)	391
643874644	389	33.93	1	389	1	389	1.0e-63	237	COG3071	Uncharacterized conserved protein HemY, contains two TPR repeats	400
643874645	404	35.12	13	397	3	401	5.0e-77	282	COG0004	Ammonia channel protein AmtB	409
643874646	140	49.62	5	136	3	135	6.0e-30	123	COG0355	FoF1-type ATP synthase, epsilon subunit	135
643874647	462	76.61	1	462	1	465	0.0e+00	826	COG0055	FoF1-type ATP synthase, beta subunit	468
643874648	287	57.69	5	287	1	286	7.0e-101	360	COG0224	FoF1-type ATP synthase, gamma subunit	287
643874649	513	64.72	1	513	1	502	0.0e+00	815	COG0056	FoF1-type ATP synthase, alpha subunit	504
643874650	177	40.45	1	176	1	178	6.0e-37	146	COG0712	FoF1-type ATP synthase, delta subunit	178
643874651	156	45.75	4	156	6	158	1.0e-18	85.7	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	161
643874653	259	44.87	2	259	1	246	6.0e-50	191	COG0356	FoF1-type ATP synthase, membrane subunit a	246
643874655	302	37.55	45	295	2	240	1.0e-32	133	COG1475	Chromosome segregation protein Spo0J, contains ParB-like nuclease domain	240
643874656	263	44.92	1	254	1	255	2.0e-62	232	COG1192	Cellulose biosynthesis protein BcsQ	259
643874657	209	48.33	8	208	5	213	2.0e-57	215	COG0357	16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B)	215
643874658	629	63.84	3	626	1	621	0.0e+00	976	COG0445	tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA	621
643874660	151	29.14	1	146	1	147	1.0e-23	101	COG0716	Flavodoxin	151
643874661	187	41.98	1	130	3	131	1.0e-32	132	COG0231	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)	131
643874662	388	42.33	9	384	4	369	2.0e-95	343	COG4394	Uncharacterized protein	370
643874664	356	24.86	10	354	14	349	2.0e-23	103	COG0628	Predicted PurR-regulated permease PerM	355
643874665	303	33.56	3	294	2	292	8.0e-41	160	COG0583	DNA-binding transcriptional regulator, LysR family	297
643874666	103	26.83	4	85	14	94	1.0e-06	45	COG5569	Periplasmic Cu and Ag efflux protein CusF	108
643874667	72	71.43	2	71	1	70	2.0e-23	100	COG3530	Uncharacterized conserved protein, DUF3820 family	71
643874668	101	33.66	1	101	10	98	2.0e-11	61	COG0640	DNA-binding transcriptional regulator, ArsR family	110
643874669	349	39.78	1	349	3	358	3.0e-88	318	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
643874670	669	62.71	7	668	5	663	0.0e+00	1067	COG0021	Transketolase	663
643874671	317	35.76	4	315	1	239	8.0e-61	227	COG0176	Transaldolase	239
643874672	152	47.97	4	150	3	150	3.0e-45	174	COG0698	Ribose 5-phosphate isomerase RpiB	151
643874674	571	28.83	129	562	2	408	6.0e-55	209	COG3395	Uncharacterized conserved protein YgbK, DUF1537 family	413
643874675	335	38.46	7	329	4	325	5.0e-86	311	COG1995	4-hydroxy-L-threonine phosphate dehydrogenase PdxA	332
643874676	261	42.47	1	259	1	251	2.0e-71	262	COG0149	Triosephosphate isomerase	251
643874677	320	40	3	316	7	319	3.0e-86	311	COG2390	DNA-binding transcriptional regulator LsrR, DeoR family	321
643874680	453	52.75	4	453	5	454	0.0e+00	547	COG0486	tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE	454
643874681	549	45.83	247	549	5	307	4.0e-76	279	COG0706	Membrane protein insertase Oxa1/YidC/SpoIIIJ, required for the localization of integral membrane proteins	314
643874682	85	51.85	4	84	2	82	1.0e-24	104	COG0759	Membrane-anchored protein YidD, putatitve component of membrane protein insertase Oxa1/YidC/SpoIIIJ	92
643874683	119	42.48	7	118	1	113	5.0e-21	93	COG0594	RNase P protein component	117
643874685	1156	31.33	620	1155	11	534	2.0e-82	301	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
644730799	246	24.48	1	240	1	284	3.0e-20	92.6	COG4974	Site-specific recombinase XerD	300
644730803	180	28.81	11	179	46	212	3.0e-17	81.7	COG2932	Phage repressor protein C, contains Cro/C1-type HTH and peptisase s24 domains	214
644730816	385	65.97	1	385	1	384	0.0e+00	582	COG1979	Alcohol dehydrogenase YqhD, Fe-dependent ADH family	384
644730820	253	29.07	1	253	77	299	2.0e-21	96.4	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
644730824	292	28.76	4	288	46	344	1.0e-40	160	COG3177	Fic family protein	348
644730832	473	35.48	3	154	2	152	7.0e-22	99	COG3666	Transposase	161
644730838	599	29.8	1	589	1	595	7.0e-100	358	COG3250	Beta-galactosidase/beta-glucuronidase	808
