gene_oid	gene_length	percent_identity	query_start	query_end	subj_start	subj_end	evalue	bit_score	cog_id	cog_name	cog_length
649941554	678	33.75	5	556	17	542	7.0e-115	408	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
649941555	886	40.69	11	877	1	781	0.0e+00	775	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
649941556	350	40	28	337	17	321	2.0e-68	252	COG3520	Predicted component of the type VI protein secretion system	335
649941557	615	38.7	1	615	1	621	0.0e+00	494	COG3519	Type VI protein secretion system component VasA	621
649941558	153	35.42	13	152	10	153	2.0e-19	88.9	COG3518	Predicted component of the type VI protein secretion system	157
649941560	243	29.17	1	230	6	264	4.0e-35	141	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion	273
649941561	158	30.91	1	155	1	159	4.0e-18	84.2	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
649941562	497	54.23	1	496	1	494	0.0e+00	669	COG3517	Predicted component of the type VI protein secretion system	495
649941563	173	48.17	2	165	1	162	2.0e-46	178	COG3516	Predicted component of the type VI protein secretion system	169
649941564	451	33.63	1	444	1	442	2.0e-83	303	COG3522	Predicted component of the type VI protein secretion system	446
649941565	672	21.9	243	659	1	400	2.0e-25	111	COG1228	Imidazolonepropionase or related amidohydrolase	406
649941567	452	32.23	1	449	1	446	1.0e-75	277	COG3522	Predicted component of the type VI protein secretion system	446
649941568	244	28.04	17	225	39	246	5.0e-18	85	COG3455	Type VI protein secretion system component VasF	262
649941569	1128	21.22	5	1071	14	1140	4.0e-64	240	COG3523	Type VI protein secretion system component VasK	1188
649941570	258	39.06	1	246	4	256	4.0e-51	194	COG0631	Serine/threonine protein phosphatase PrpC	262
649941571	421	35.53	46	409	2	374	1.0e-71	263	COG0006	Xaa-Pro aminopeptidase	384
649941572	232	29.73	4	220	10	230	1.0e-33	136	COG1802	DNA-binding transcriptional regulator, GntR family	230
649941573	975	43.65	780	957	1	180	8.0e-43	169	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
649941575	557	39.19	2	308	10	356	2.0e-75	276	COG1239	Mg-chelatase subunit ChlI	423
649941576	1460	36.8	149	1459	16	1261	0.0e+00	1032	COG1429	Cobalamin biosynthesis protein CobN, Mg-chelatase	1388
649941579	194	27.04	1	181	1	195	1.0e-11	63.3	COG0406	Broad specificity phosphatase PhoE	208
649941584	321	25	53	293	23	252	9.0e-12	64.5	COG1082	Sugar phosphate isomerase/epimerase	274
649941586	291	22.34	42	283	2	273	8.0e-18	84.5	COG1082	Sugar phosphate isomerase/epimerase	274
649941587	439	24	36	407	3	334	2.0e-31	130	COG0673	Predicted dehydrogenase	342
649941591	465	15.65	24	460	37	346	4.0e-09	56.5	COG2837	Periplasmic deferrochelatase/peroxidase EfeB	352
649941592	815	19.84	124	815	58	750	2.0e-18	88.5	COG4774	Outer membrane receptor for monomeric catechols	750
649941593	148	31.03	5	148	1	145	1.0e-25	109	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
649941594	745	70.81	6	743	1	730	0.0e+00	1139	COG0376	Catalase (peroxidase I)	730
649941595	349	19.86	56	330	19	280	3.0e-13	69.7	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649941596	424	28.95	1	415	1	399	3.0e-46	179	COG1819	UDP:flavonoid glycosyltransferase YjiC, YdhE family	406
649941597	377	25.18	1	376	1	407	9.0e-25	108	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
649941599	520	32.21	1	520	13	532	3.0e-79	289	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
649941601	221	54.09	5	219	1	220	3.0e-73	268	COG1136	ABC-type lipoprotein export system, ATPase component	226
649941602	1137	23.32	393	613	47	293	4.0e-03	37.7	COG3386	Sugar lactone lactonase YvrE	307
649941603	648	20.49	34	360	41	310	5.0e-15	76.6	COG2273	Beta-glucanase, GH16 family	355
649941605	527	17.42	115	524	10	399	3.0e-25	110	COG3464	Transposase	402
649941607	434	18.78	89	331	58	286	9.0e-06	45.2	COG4975	Glucose uptake protein GlcU	288
649941610	743	33.33	12	728	32	746	0.0e+00	461	COG3537	Putative alpha-1,2-mannosidase	768
649941611	348	40.96	3	333	1	329	6.0e-74	271	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
649941621	835	34.15	45	166	1	123	2.0e-21	98.5	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	148
649941622	311	30.85	1	277	11	292	4.0e-38	152	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
649941623	847	43.18	20	500	4	487	0.0e+00	532	COG2308	Uncharacterized conserved protein, circularly permuted ATPgrasp superfamily	488
649941624	1092	41.64	286	1080	3	808	0.0e+00	659	COG4196	Uncharacterized conserved protein, DUF2126 family	808
649941627	468	29.27	45	465	13	433	2.0e-76	279	COG1362	Aspartyl aminopeptidase	437
649941633	222	24.18	34	213	4	180	6.0e-05	41.2	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649941635	553	28.31	42	552	13	547	1.0e-64	241	COG3507	Beta-xylosidase	549
649941636	663	29.07	91	339	12	269	5.0e-15	76.5	COG0457	Tetratricopeptide (TPR) repeat	291
649941639	751	35.32	21	745	11	728	0.0e+00	487	COG1529	CO or xanthine dehydrogenase, Mo-binding subunit	731
649941640	327	39.04	1	327	1	283	3.0e-61	229	COG1319	CO or xanthine dehydrogenase, FAD-binding subunit	284
649941641	214	59.21	63	213	2	153	4.0e-59	221	COG2080	Aerobic-type carbon monoxide dehydrogenase, small subunit, CoxS/CutS family	156
649941646	455	21.72	44	439	3	338	9.0e-28	118	COG0673	Predicted dehydrogenase	342
649941648	210	44.08	7	209	1	211	5.0e-47	180	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649941649	325	37.2	1	307	1	326	4.0e-54	205	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
649941650	1012	24.1	640	990	22	365	9.0e-36	146	COG4585	Signal transduction histidine kinase	365
649941652	714	22.22	404	626	11	232	2.0e-09	58	COG0668	Small-conductance mechanosensitive channel	316
649941654	239	32.34	3	229	8	241	5.0e-39	154	COG1360	Flagellar motor protein MotB	244
649941655	267	37.11	6	258	1	256	5.0e-53	201	COG1291	Flagellar motor component MotA	266
649941656	71	46.55	1	58	1	58	1.0e-12	64.5	COG1582	Uncharacterized protein YlzI, FlbEa/FlbD family	67
649941657	272	27.52	3	256	1	258	3.0e-13	68.9	COG1344	Flagellin and related hook-associated protein FlgL	360
649941658	449	25.93	9	448	3	483	1.0e-29	124	COG1345	Flagellar capping protein FliD	483
649941659	156	25.21	1	119	2	120	2.0e-11	61.9	COG1516	Flagellin-specific chaperone FliS	132
649941660	297	22.06	8	285	9	289	2.0e-13	69.7	COG1344	Flagellin and related hook-associated protein FlgL	360
649941661	457	30.77	3	414	2	430	4.0e-43	169	COG1256	Flagellar hook-associated protein FlgK	552
649941665	382	51.23	18	382	5	365	3.0e-97	349	COG1706	Flagellar basal body P-ring protein FlgI	365
649941666	231	26.34	1	218	1	221	5.0e-27	114	COG2063	Flagellar basal body L-ring protein FlgH	230
649941668	263	51.7	1	261	1	263	1.0e-71	262	COG4786	Flagellar basal body rod protein FlgG	265
649941669	246	34.6	1	240	1	262	9.0e-39	153	COG4786	Flagellar basal body rod protein FlgG	265
649941670	228	23.71	25	228	14	245	1.0e-10	60	COG1639	HD-like signal output (HDOD) domain, no enzymatic activity	289
649941672	321	25.41	19	316	32	332	4.0e-33	135	COG1868	Flagellar motor switch protein FliM	332
649941673	278	36.55	1	247	5	245	2.0e-45	176	COG1191	DNA-directed RNA polymerase specialized sigma subunit	247
649941674	711	49.42	29	711	17	694	0.0e+00	708	COG1298	Flagellar biosynthesis pathway, component FlhA	696
649941675	367	34.46	1	351	4	357	2.0e-84	306	COG1377	Flagellar biosynthesis protein FlhB	363
649941676	258	33.6	2	251	5	254	1.0e-31	130	COG1684	Flagellar biosynthesis protein FliR	258
649941677	89	36.36	1	88	1	88	2.0e-10	57.5	COG1987	Flagellar biosynthesis protein FliQ	89
649941678	236	45.99	1	236	12	248	2.0e-58	219	COG1338	Flagellar biosynthetic protein FliP	248
649941682	412	41.09	8	409	9	421	3.0e-60	226	COG1749	Flagellar hook protein FlgE	423
649941685	145	24.83	1	145	1	145	2.0e-03	35.3	COG2882	Flagellar biosynthesis chaperone FliJ	148
649941686	434	53.69	3	434	7	440	0.0e+00	537	COG1157	Flagellar biosynthesis/type III secretory pathway ATPase	441
649941687	219	30.85	33	217	48	232	1.0e-18	86.6	COG1317	Flagellar biosynthesis/type III secretory pathway protein FliH	234
649941688	341	40.66	9	340	10	339	7.0e-65	241	COG1536	Flagellar motor switch protein FliG	339
649941689	525	33.33	4	520	5	542	6.0e-80	291	COG1766	Flagellar biosynthesis/type III secretory pathway M-ring protein FliF/YscJ	545
649941690	102	40.26	25	101	28	104	5.0e-13	66.1	COG1677	Flagellar hook-basal body complex protein FliE	105
649941691	148	39.86	1	147	1	137	4.0e-36	143	COG1558	Flagellar basal body rod protein FlgC	137
649941692	117	31.71	11	116	11	133	1.0e-15	75	COG1815	Flagellar basal body rod protein FlgB	133
649941693	454	43.82	3	453	1	461	0.0e+00	484	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
649941694	418	31.82	183	416	93	328	5.0e-30	125	COG0642	Signal transduction histidine kinase	336
649941695	352	43.8	3	352	29	386	1.0e-91	330	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
649941696	262	36.68	38	262	1	228	2.0e-48	185	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649941698	309	32.52	10	240	1	242	5.0e-45	175	COG1360	Flagellar motor protein MotB	244
649941699	290	32.62	1	282	3	263	6.0e-54	204	COG1291	Flagellar motor component MotA	266
649941701	149	27.17	43	134	29	120	2.0e-07	48.4	COG1846	DNA-binding transcriptional regulator, MarR family	126
649941702	206	40.64	1	182	1	182	4.0e-45	174	COG1182	FMN-dependent NADH-azoreductase	202
649941703	440	47.16	23	426	14	407	2.0e-85	309	COG0738	Fucose permease	422
649941704	188	57.84	5	184	1	185	9.0e-67	246	COG2818	3-methyladenine DNA glycosylase Tag	188
649941709	213	48.24	12	206	2	200	2.0e-51	195	COG4245	Uncharacterized conserved protein YegL, contains vWA domain of TerY type	207
649941711	482	26.07	15	482	2	421	1.0e-41	164	COG5316	Uncharacterized protein	421
649941713	317	22.86	91	260	2	166	3.0e-10	59.3	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649941715	342	26.51	39	314	1	289	3.0e-30	126	COG1453	Predicted oxidoreductase of the aldo/keto reductase family	391
649941718	647	26.54	31	638	5	556	9.0e-60	225	COG3975	Predicted metalloprotease, contains C-terminal PDZ domain	558
649941719	557	31.13	35	545	1	473	4.0e-71	262	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649941721	442	27.86	68	422	19	372	5.0e-31	129	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
649941722	1171	34.83	4	781	3	775	0.0e+00	678	COG0841	Multidrug efflux pump subunit AcrB	1009
649941723	1034	38.94	2	1014	1	1009	0.0e+00	906	COG0841	Multidrug efflux pump subunit AcrB	1009
649941724	523	32.53	14	509	1	456	6.0e-59	221	COG1538	Outer membrane protein TolC	457
649941725	435	52.87	1	433	2	436	1.0e-107	384	COG2252	Xanthine/uracil/vitamin C permease, AzgA family	436
649941726	350	38.46	4	348	11	347	9.0e-81	294	COG5042	Purine nucleoside permease	349
649941727	574	38.82	17	436	21	443	2.0e-65	243	COG0038	H+/Cl- antiporter ClcA	443
649941730	566	15	53	552	66	589	3.0e-20	93.9	COG1874	Beta-galactosidase GanA	673
649941732	310	27.84	19	297	43	327	3.0e-27	115	COG2367	Beta-lactamase class A	329
649941735	237	20.75	1	225	3	258	3.0e-13	69.1	COG1192	Cellulose biosynthesis protein BcsQ	259
649941738	394	29.79	15	386	13	373	7.0e-25	108	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649941741	1665	18.17	119	1292	59	1115	2.0e-26	115	COG4934	Serine protease, subtilase family	1174
649941742	162	50.33	6	154	4	151	5.0e-45	173	COG3865	Glyoxalase superfamily enzyme, possibly 3-demethylubiquinone-9 3-methyltransferase	151
649941743	257	39.67	136	255	6	125	3.0e-25	108	COG3324	Predicted enzyme related to lactoylglutathione lyase	127
649941744	784	35.57	30	782	39	758	0.0e+00	502	COG3537	Putative alpha-1,2-mannosidase	768
649941746	552	53.64	15	552	7	554	0.0e+00	671	COG2759	Formyltetrahydrofolate synthetase	554
649941747	489	42.01	47	486	4	453	4.0e-118	418	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
649941750	362	32.87	77	359	61	333	1.0e-38	154	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
649941751	449	19.61	20	430	19	387	6.0e-13	69.1	COG2814	Predicted arabinose efflux permease, MFS family	394
649941753	363	26.61	63	363	35	355	8.0e-33	134	COG4225	Rhamnogalacturonyl hydrolase YesR	357
649941755	750	22.55	514	679	37	236	3.0e-07	51	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	254
649941761	613	34.07	53	573	1	496	1.0e-78	288	COG0366	Glycosidase	505
649941762	537	36.85	100	535	143	554	3.0e-88	319	COG1626	Neutral trehalase	558
649941765	809	31.29	23	168	1	140	1.0e-18	89.3	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	148
649941769	322	32.86	45	322	55	291	3.0e-33	135	COG2159	Predicted metal-dependent hydrolase, TIM-barrel fold	293
649941772	376	34.01	14	356	7	332	4.0e-63	235	COG3693	Endo-1,4-beta-xylanase, GH35 family	345
649941773	642	28.82	129	624	128	640	9.0e-72	264	COG5001	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	663
649941778	558	21.96	8	538	7	575	2.0e-22	101	COG4805	Uncharacterized conserved protein, DUF885 familyt	588
649941779	772	22.4	46	768	21	752	2.0e-64	241	COG0308	Aminopeptidase N	859
649941781	985	31.11	362	912	39	558	2.0e-82	301	COG3533	Uncharacterized conserved protein, DUF1680 family	589
649941782	800	28.36	33	627	8	576	1.0e-94	341	COG3533	Uncharacterized conserved protein, DUF1680 family	589
649941783	530	25.6	11	503	6	472	6.0e-57	215	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
649941784	319	39.04	1	318	1	333	2.0e-84	305	COG3938	Proline racemase	341
649941785	377	28.24	1	371	2	384	5.0e-36	145	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
649941787	432	20.98	6	399	1	390	9.0e-21	95	COG0446	NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase	415
649941788	307	33.56	1	289	3	293	3.0e-60	225	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
649941790	222	27.4	25	164	1	140	1.0e-15	77.2	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
649941792	471	29.47	63	449	30	375	4.0e-43	169	COG0006	Xaa-Pro aminopeptidase	384
649941793	244	26.47	6	243	2	230	5.0e-25	108	COG1802	DNA-binding transcriptional regulator, GntR family	230
649941797	740	31.53	100	712	106	740	6.0e-109	388	COG1501	Alpha-glucosidase, glycosyl hydrolase family GH31	772
649941801	125	41.49	32	125	1	94	1.0e-12	65.5	COG0776	Bacterial nucleoid DNA-binding protein	94
649941805	418	22.22	26	410	11	390	2.0e-16	80.6	COG2814	Predicted arabinose efflux permease, MFS family	394
649941813	125	41.49	32	125	1	94	1.0e-12	65.5	COG0776	Bacterial nucleoid DNA-binding protein	94
649941819	545	25.72	54	355	18	352	6.0e-31	129	COG3669	Alpha-L-fucosidase	430
649941820	132	54.84	1	124	5	128	9.0e-43	165	COG5649	Uncharacterized protein	132
649941822	125	29.31	7	112	5	119	2.0e-08	51.3	COG1487	Predicted nucleic acid-binding protein, contains PIN domain	133
649941825	577	22.79	271	482	10	220	7.0e-07	49.2	COG3063	Tfp pilus assembly protein PilF	250
649941828	158	17.73	1	134	1	141	1.0e-05	42.6	COG3678	Periplasmic protein refolding chaperone Spy/CpxP family	160
649941829	227	43.56	1	221	5	228	4.0e-50	191	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649941830	458	34.09	149	451	37	335	3.0e-40	159	COG0642	Signal transduction histidine kinase	336
649941834	476	20.47	3	427	4	369	3.0e-14	73.3	COG2814	Predicted arabinose efflux permease, MFS family	394
649941837	1018	32.98	12	265	1	279	2.0e-43	171	COG0515	Serine/threonine protein kinase	384
649941841	202	18.63	11	170	3	163	7.0e-05	40.8	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649941846	544	27.5	268	540	57	330	3.0e-29	123	COG0642	Signal transduction histidine kinase	336
649941848	385	33.76	1	382	1	350	9.0e-67	247	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
649941849	284	26.32	1	274	1	282	4.0e-30	125	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649941850	300	22.11	6	297	5	281	6.0e-20	91.7	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649941853	247	33.02	1	212	5	213	6.0e-38	151	COG1878	Kynurenine formamidase	218
649941854	366	32.47	17	353	13	356	3.0e-51	196	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
649941855	582	37.01	1	557	2	550	0.0e+00	467	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
649941856	519	25.54	104	519	43	456	9.0e-35	141	COG1538	Outer membrane protein TolC	457
649941857	527	30.05	131	523	3	338	2.0e-58	220	COG1566	Multidrug resistance efflux pump	352
649941859	486	23.13	65	463	41	381	4.0e-13	69.8	COG2814	Predicted arabinose efflux permease, MFS family	394
649941866	364	24.2	90	362	26	295	4.0e-32	132	COG1533	DNA repair photolyase	297
649941870	69	50	1	67	1	67	9.0e-17	78.6	COG1278	Cold shock protein, CspA family	67
649941871	234	26.09	3	202	1	207	6.0e-15	74.5	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649941876	531	24.47	238	512	57	330	4.0e-27	116	COG0642	Signal transduction histidine kinase	336
649941877	268	26.47	6	207	7	209	2.0e-23	102	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649941881	95	44.44	19	90	3	74	9.0e-14	68.3	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649941883	242	30.33	6	242	93	329	2.0e-27	116	COG0642	Signal transduction histidine kinase	336
649941886	83	56.25	6	68	4	67	9.0e-20	88.7	COG1278	Cold shock protein, CspA family	67
649941887	254	21.88	22	206	21	212	3.0e-15	75.6	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649941894	225	37.67	22	216	4	216	8.0e-28	117	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649941895	384	19.54	84	382	12	282	1.0e-10	60.9	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649941896	192	38.89	3	186	1	198	5.0e-28	117	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649941898	272	17.81	13	270	5	286	1.0e-22	100	COG2842	Bacteriophage DNA transposition protein, AAA+ family ATPase	297
649941899	321	24.7	66	309	2	220	6.0e-17	81.7	COG3039	Transposase and inactivated derivatives, IS5 family	230
649941900	406	43.24	322	395	1	74	3.0e-12	66.7	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649941903	543	39.29	5	254	5	256	1.0e-64	241	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
649941906	464	27.77	16	456	15	425	7.0e-41	161	COG4487	Uncharacterized protein	438
649941910	399	20.8	10	399	15	406	1.0e-61	230	COG4320	Uncharacterized conserved protein, DUF2252 family	410
649941911	168	34.69	1	146	3	143	5.0e-26	110	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
649941912	197	43.9	1	164	4	167	2.0e-29	121	COG3685	Ferritin-like metal-binding protein YciE	167
649941915	1069	35.45	5	1064	4	1067	0.0e+00	881	COG0587	DNA polymerase III, alpha subunit	1139
649941916	502	22.8	30	322	29	318	1.0e-12	68.1	COG0389	Nucleotidyltransferase/DNA polymerase involved in DNA repair	354
649941918	149	54.23	5	146	3	140	3.0e-42	164	COG5579	Uncharacterized protein, DUF1810 family	143
649941920	170	32.17	6	148	23	163	6.0e-18	83.9	COG4420	Uncharacterized membrane protein	191
649941922	222	38.16	1	205	1	205	2.0e-45	175	COG2135	Putative SOS response-associated peptidase YedK	226
649941923	124	32.29	28	122	15	110	1.0e-07	49	COG0640	DNA-binding transcriptional regulator, ArsR family	110
649941925	377	25.22	147	374	2	229	2.0e-14	73.5	COG1814	Predicted Fe2+/Mn2+ transporter, VIT1/CCC1 family	229
649941927	242	31.67	22	241	12	221	8.0e-13	67.6	COG3619	Uncharacterized membrane protein YoaK, UPF0700 family	226
649941930	255	25.98	6	207	7	209	7.0e-22	97.6	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649941931	245	27.94	25	224	18	213	1.0e-18	86.5	COG3619	Uncharacterized membrane protein YoaK, UPF0700 family	226
649941932	206	28.04	11	192	5	207	3.0e-12	65.4	COG0778	Nitroreductase	207
649941933	387	31.73	182	385	2	205	7.0e-36	145	COG2140	Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily	209
649941935	720	43.18	36	714	15	691	0.0e+00	645	COG1523	Pullulanase/glycogen debranching enzyme	697
649941937	169	31.79	8	156	2	152	6.0e-16	76.9	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
649941938	543	41.34	2	543	13	563	0.0e+00	515	COG4716	Myosin-crossreactive antigen  (function unknown)	587
649941940	154	41.14	1	152	1	155	3.0e-32	130	COG1225	Peroxiredoxin	157
649941941	178	26.11	1	173	65	243	2.0e-22	99.1	COG1651	Protein-disulfide isomerase	244
649941942	330	35.99	1	330	4	337	6.0e-74	271	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
649941943	455	38.95	1	454	14	467	6.0e-115	408	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
649941945	324	36.25	1	313	1	322	1.0e-57	217	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
649941947	419	21.39	4	352	30	393	2.0e-15	77.2	COG2271	Sugar phosphate permease	448
649941948	560	37.39	1	556	3	557	0.0e+00	583	COG3961	TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase	557
649941954	392	59.38	157	316	1	158	1.0e-49	190	COG4804	Predicted nuclease of restriction endonuclease-like (RecB) superfamily,  DUF1016 family	159
649941955	225	22.31	1	219	2	256	3.0e-18	85.6	COG1192	Cellulose biosynthesis protein BcsQ	259
649941961	789	22.28	25	745	21	744	4.0e-46	180	COG3451	Type IV secretory pathway, VirB4 component	796
649941969	320	40.48	13	304	49	336	5.0e-61	228	COG4962	Pilus assembly protein, ATPase of CpaF family	355
649941975	321	24.29	66	309	2	220	4.0e-17	82.5	COG3039	Transposase and inactivated derivatives, IS5 family	230
649941976	202	34.34	18	196	2	197	2.0e-22	99.5	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649941984	374	26.19	118	364	72	298	3.0e-16	79.6	COG2382	Enterochelin esterase or related enzyme	299
649941989	245	36.78	1	239	2	243	1.0e-37	150	COG3279	DNA-binding response regulator, LytR/AlgR family	244
649941991	769	35.93	139	769	6	654	0.0e+00	527	COG3590	Predicted metalloendopeptidase	654
649941993	261	36.11	9	258	2	242	1.0e-39	156	COG3279	DNA-binding response regulator, LytR/AlgR family	244
649941997	522	23.82	21	367	9	365	2.0e-34	141	COG1680	CubicO group peptidase, beta-lactamase class C family	390
649941998	213	26.49	30	211	6	190	3.0e-06	45.8	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649941999	349	21.99	43	313	44	312	7.0e-16	78.3	COG3391	DNA-binding beta-propeller fold protein YncE	381
649942000	274	27.35	29	260	15	243	1.0e-16	80.4	COG4705	Uncharacterized membrane-anchored protein	258
649942001	319	32.59	11	313	2	312	1.0e-34	140	COG0657	Acetyl esterase/lipase	312
649942002	202	23.96	1	188	3	194	7.0e-07	47.3	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649942004	476	23.48	5	136	8	134	2.0e-03	37.2	COG3415	Transposase	138
649942005	503	17.42	91	500	10	399	3.0e-25	110	COG3464	Transposase	402
649942007	82	41.79	15	80	8	74	8.0e-10	55.6	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649942009	82	32.88	1	73	2	72	1.0e-04	38.1	COG4118	Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor	84
649942010	128	45.67	2	128	3	129	1.0e-27	115	COG3744	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain)	130
649942011	275	23.29	32	273	7	255	2.0e-29	123	COG0300	Short-chain dehydrogenase	265
649942012	453	20.45	52	435	59	442	2.0e-31	130	COG0277	FAD/FMN-containing dehydrogenase	459
649942014	417	33.17	2	412	64	457	7.0e-78	284	COG1109	Phosphomannomutase	464
649942015	199	22.95	5	182	23	199	1.0e-09	56.4	COG2949	Uncharacterized periplasmic protein SanA, affects membrane permeability for vancomycin	235
649942017	310	27.34	11	282	3	284	2.0e-39	156	COG1442	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase	325
649942018	496	26.3	195	496	8	289	5.0e-24	106	COG0382	4-hydroxybenzoate polyprenyltransferase	289
649942019	84	37.29	24	81	6	64	2.0e-05	41	COG3655	DNA-binding transcriptional regulator, XRE family	73
649942020	418	20.9	68	326	82	311	4.0e-08	53.1	COG0189	Glutathione synthase/RimK-type ligase, ATP-grasp superfamily	318
649942022	414	24.55	67	388	51	363	7.0e-20	92	COG3550	Serine/threonine protein kinase HipA, toxin component of the HipAB toxin-antitoxin module	392
649942032	247	25.12	9	207	6	206	2.0e-15	76.3	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649942034	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649942039	106	49.49	3	101	1	99	4.0e-25	106	COG3636	DNA-binding prophage protein	100
649942041	136	26.24	1	136	3	131	2.0e-12	65.2	COG1487	Predicted nucleic acid-binding protein, contains PIN domain	133
649942056	203	23.92	3	202	5	256	1.0e-16	79.9	COG1192	Cellulose biosynthesis protein BcsQ	259
649942060	484	21.64	109	467	29	381	1.0e-17	84.7	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649942061	328	24.66	6	291	4	290	7.0e-18	84.8	COG1216	Glycosyltransferase, GT2 family	305
649942062	384	21.92	38	373	13	365	5.0e-15	76	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649942063	304	43.19	4	304	3	281	2.0e-75	276	COG1091	dTDP-4-dehydrorhamnose reductase	281
649942064	291	57.29	1	288	1	285	5.0e-116	410	COG1209	dTDP-glucose pyrophosphorylase	286
649942065	379	60	20	369	3	339	0.0e+00	514	COG1088	dTDP-D-glucose 4,6-dehydratase	340
649942066	200	51.74	14	185	1	168	2.0e-55	208	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	173
649942067	498	23.87	20	475	2	465	1.0e-25	111	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
649942073	386	27.47	23	386	13	378	1.0e-31	130	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649942074	399	25.5	3	397	1	380	2.0e-33	136	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649942075	440	20.15	14	411	15	416	5.0e-17	82.8	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
649942077	355	27.37	1	352	3	380	9.0e-32	131	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649942083	215	28.57	28	197	44	211	7.0e-20	90.6	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
649942085	483	20.04	1	450	17	458	2.0e-23	104	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
649942087	900	29.97	499	873	1	371	3.0e-51	197	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
649942089	501	49.5	300	500	34	225	8.0e-64	238	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
649942090	363	23.5	1	358	1	377	3.0e-23	102	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649942095	327	26.04	51	310	28	281	1.0e-25	110	COG4974	Site-specific recombinase XerD	300
649942098	611	25.09	68	608	64	620	3.0e-65	243	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
649942099	220	19.88	15	180	5	170	2.0e-05	43.1	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649942106	386	42.17	56	385	1	317	3.0e-77	282	COG2826	Transposase and inactivated derivatives, IS30 family	318
649942119	223	27.62	9	208	6	197	2.0e-17	82.5	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649942125	728	18.4	132	574	54	534	5.0e-27	116	COG3505	Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase	596
649942128	300	40.57	1	279	63	337	6.0e-58	217	COG4962	Pilus assembly protein, ATPase of CpaF family	355
649942129	288	23.71	14	242	18	224	1.0e-03	37.7	COG3701	Type IV secretory pathway, TrbF components	228
649942133	459	26.17	202	449	98	353	8.0e-24	105	COG2948	Type IV secretory pathway, VirB10 components	360
649942134	279	20.16	7	243	6	210	4.0e-04	38.8	COG3504	Type IV secretory pathway, VirB9 components	265
649942135	789	23.02	26	724	21	722	1.0e-48	189	COG3451	Type IV secretory pathway, VirB4 component	796
649942140	392	27.25	20	381	39	391	1.0e-46	180	COG1373	Predicted ATPase, AAA+ superfamily	398
649942143	197	24.02	1	173	3	230	1.0e-19	89.9	COG1192	Cellulose biosynthesis protein BcsQ	259
649942145	320	29.93	34	314	23	296	1.0e-25	110	COG4974	Site-specific recombinase XerD	300
649942149	668	46.37	14	259	7	254	7.0e-72	265	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
649942150	297	26.32	7	288	2	279	5.0e-25	108	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649942151	464	27.27	14	456	13	425	3.0e-40	160	COG4487	Uncharacterized protein	438
649942153	617	23.36	9	604	1	580	4.0e-66	246	COG3593	Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains	581
649942154	574	20.78	7	550	6	614	2.0e-29	124	COG0210	Superfamily I DNA or RNA helicase	655
649942155	211	35.78	21	204	2	203	8.0e-26	110	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649942157	343	27.52	6	328	3	303	7.0e-29	121	COG3547	Transposase	303
649942159	647	31.76	17	291	36	331	2.0e-22	101	COG1413	HEAT repeat	335
649942160	317	27.11	34	305	23	294	4.0e-22	99.1	COG4974	Site-specific recombinase XerD	300
649942164	512	34.14	259	507	2	226	3.0e-17	83.9	COG2801	Transposase InsO and inactivated derivatives	232
649942166	200	37.88	12	195	1	198	2.0e-27	115	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649942168	211	36.27	21	204	2	203	2.0e-25	109	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649942178	157	27.38	4	156	7	159	1.0e-17	82.8	COG4306	Uncharacterized protein	160
649942186	513	16.47	97	510	6	399	2.0e-24	107	COG3464	Transposase	402
649942189	132	35.11	38	131	1	94	1.0e-09	55.5	COG0776	Bacterial nucleoid DNA-binding protein	94
649942193	174	22.39	39	170	7	136	2.0e-04	38.8	COG4319	Ketosteroid isomerase homolog	137
649942196	245	37.3	3	241	2	238	1.0e-37	150	COG3279	DNA-binding response regulator, LytR/AlgR family	244
649942199	385	25.14	21	370	8	365	2.0e-33	136	COG4585	Signal transduction histidine kinase	365
649942200	207	38.76	8	207	1	209	1.0e-43	169	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649942202	125	41.49	32	125	1	94	1.0e-13	68.6	COG0776	Bacterial nucleoid DNA-binding protein	94
649947417	492	52.4	155	488	77	407	5.0e-114	405	COG0593	Chromosomal replication initiation ATPase DnaA	408
649947419	397	33.86	21	397	1	364	9.0e-62	231	COG0592	DNA polymerase III sliding clamp (beta) subunit, PCNA homolog	364
649947424	344	22.02	56	331	74	399	2.0e-18	86.8	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
649947425	189	22.06	42	171	13	141	9.0e-03	33.5	COG3832	Uncharacterized conserved protein YndB, AHSA1/START domain	149
649947427	865	14.08	70	826	33	760	6.0e-10	60.3	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
649947429	848	32.57	19	846	6	753	3.0e-115	410	COG1193	dsDNA-specific endonuclease/ATPase MutS2	753
649947430	684	38.43	40	683	9	651	0.0e+00	566	COG3590	Predicted metalloendopeptidase	654
649947433	329	58.46	6	328	8	327	0.0e+00	475	COG0113	Delta-aminolevulinic acid dehydratase, porphobilinogen synthase	330
649947436	489	45.13	6	475	5	450	0.0e+00	463	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
649947439	252	40.45	5	224	13	211	7.0e-54	203	COG0321	Lipoate-protein ligase B	221
649947440	545	41.19	124	541	3	399	1.0e-96	347	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	404
649947443	388	43.39	10	386	1	366	2.0e-106	379	COG0026	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	375
649947444	165	61.35	1	163	2	162	4.0e-53	200	COG0041	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	162
649947449	422	64.23	7	416	5	413	0.0e+00	633	COG0112	Glycine/serine hydroxymethyltransferase	413
649947450	158	37.96	11	147	9	143	7.0e-16	76.6	COG3918	Uncharacterized membrane protein	153
649947451	626	37.48	109	613	65	586	1.0e-122	434	COG4805	Uncharacterized conserved protein, DUF885 familyt	588
649947454	714	32.4	1	594	1	551	3.0e-113	403	COG0550	DNA topoisomerase IA	570
649947458	668	33.78	134	639	128	644	9.0e-93	335	COG5001	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	663
649947460	312	28.11	26	306	2	257	7.0e-33	134	COG0584	Glycerophosphoryl diester phosphodiesterase	257
649947464	496	29.32	55	496	2	426	6.0e-53	202	COG3664	Beta-xylosidase	428
649947468	256	45.28	2	253	9	260	1.0e-70	259	COG3823	Glutamine cyclotransferase	262
649947470	295	25.31	59	286	87	320	4.0e-19	89	COG2367	Beta-lactamase class A	329
649947471	407	27.82	18	405	1	417	5.0e-30	126	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649947472	419	27.06	21	419	1	419	7.0e-36	145	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649947473	392	20.9	23	376	29	374	3.0e-24	106	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
649947475	566	51.79	228	561	11	342	2.0e-87	317	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
649947476	356	23.91	11	318	21	333	7.0e-28	118	COG4638	Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit	367
649947477	654	26.33	4	492	2	434	4.0e-26	113	COG1807	4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of PMT family	535
649947479	103	30.53	4	97	3	92	2.0e-05	40.8	COG3668	Plasmid stabilization system protein ParE	98
649947482	239	33.91	14	237	64	279	5.0e-40	157	COG0122	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase	285
649947484	1071	26.92	829	1059	1	190	2.0e-37	152	COG0437	Fe-S-cluster-containing dehydrogenase component	203
649947485	480	20.76	54	456	15	390	9.0e-15	75.4	COG5557	Ni/Fe-hydrogenase 2 integral membrane subunit HybB	401
649947490	307	24.54	11	225	6	197	1.0e-16	80.5	COG1999	Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family	207
649947491	347	32.06	16	220	16	222	1.0e-41	164	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	247
649947492	557	47.86	29	535	5	517	0.0e+00	475	COG0843	Heme/copper-type cytochrome/quinol oxidase, subunit 1	566
649947493	258	25.53	18	252	6	206	4.0e-29	121	COG1845	Heme/copper-type cytochrome/quinol oxidase, subunit 3	209
649947495	424	27.68	40	424	1	419	7.0e-29	121	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649947497	418	24.84	113	391	2	281	2.0e-19	90.3	COG4974	Site-specific recombinase XerD	300
649947500	395	25.25	77	369	8	300	2.0e-26	113	COG4974	Site-specific recombinase XerD	300
649947501	346	29.89	45	304	31	287	2.0e-26	112	COG4974	Site-specific recombinase XerD	300
649947502	304	26.86	3	298	9	296	4.0e-37	148	COG4974	Site-specific recombinase XerD	300
649947504	935	18.48	85	483	33	483	7.0e-12	66.7	COG2189	Adenine specific DNA methylase Mod	590
649947507	241	25.98	8	199	1	184	6.0e-08	51.5	COG1751	Uncharacterized protein	186
649947514	161	39.26	5	138	7	133	3.0e-27	114	COG3600	Uncharacterized phage-associated protein	154
649947515	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649947519	212	26.25	40	199	4	163	2.0e-28	119	COG3663	G:T/U-mismatch repair DNA glycosylase	169
649947520	312	41.75	9	290	3	262	2.0e-73	269	COG0656	Aldo/keto reductase, related to diketogulonate reductase	280
649947521	243	32.59	3	223	6	213	6.0e-30	124	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649947522	313	22.76	10	295	6	280	1.0e-15	77.8	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649947525	304	34.95	199	301	19	121	2.0e-19	89.9	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
649947528	422	31.75	7	390	7	406	1.0e-61	230	COG2223	Nitrate/nitrite transporter NarK	417
649947530	529	42.48	43	191	3	155	9.0e-46	178	COG0437	Fe-S-cluster-containing dehydrogenase component	203
649947531	577	44.71	4	577	3	587	0.0e+00	547	COG0369	Sulfite reductase, alpha subunit (flavoprotein)	587
649947532	602	34.36	115	598	42	508	5.0e-95	342	COG0155	Sulfite reductase, beta subunit (hemoprotein)	510
649947534	557	25.19	8	272	1	245	7.0e-18	85.9	COG1587	Uroporphyrinogen-III synthase	248
649947538	243	23.12	25	210	13	193	6.0e-08	51.6	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649947539	137	41.12	31	135	19	123	6.0e-11	60	COG0599	Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family	124
649947540	255	42.63	16	252	3	250	2.0e-43	169	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649947541	345	39.88	1	327	1	316	4.0e-80	291	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
649947542	257	43.65	3	245	2	251	2.0e-49	189	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649947543	310	40.84	51	308	12	261	4.0e-64	238	COG0179	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	266
649947545	518	28.48	3	450	1	423	8.0e-48	185	COG1696	D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily	425
649947547	599	37.99	27	561	16	546	5.0e-111	395	COG3882	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis	574
649947548	85	23.75	4	83	1	80	4.0e-05	39.5	COG0236	Acyl carrier protein	80
649947551	510	29.42	39	481	4	443	3.0e-53	203	COG3119	Arylsulfatase A or related enzyme	475
649947554	405	40.51	5	395	4	389	4.0e-106	378	COG0282	Acetate kinase	396
649947557	354	27.91	12	330	2	314	2.0e-39	156	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649947559	461	33.76	63	456	13	372	5.0e-90	325	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
649947560	186	26.24	1	177	1	195	2.0e-17	82.4	COG0288	Carbonic anhydrase	207
649947561	321	28.29	22	320	27	322	3.0e-34	139	COG4977	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain	328
649947564	408	47.86	1	394	5	391	3.0e-93	335	COG0452	Phosphopantothenoylcysteine synthetase/decarboxylase	392
649947565	305	56.99	1	285	1	282	3.0e-99	355	COG0414	Panthothenate synthetase	285
649947566	295	54.17	17	280	1	264	1.0e-95	343	COG0413	Ketopantoate hydroxymethyltransferase	268
649947569	245	19.34	1	236	3	242	6.0e-15	74.8	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649947570	552	21.07	3	536	11	453	5.0e-26	112	COG3511	Phospholipase C	527
649947572	149	31.69	8	142	2	143	3.0e-17	81.6	COG2172	Anti-sigma regulatory factor (Ser/Thr protein kinase)	146
649947573	113	24.56	1	113	1	114	3.0e-09	53.9	COG1366	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	117
649947574	521	21.16	191	519	93	429	8.0e-17	82.3	COG2234	Zn-dependent amino- or carboxypeptidase, M28 family	435
649947575	264	27.12	31	263	10	240	2.0e-22	99.6	COG0748	Putative heme iron utilization protein	245
649947577	359	40.46	18	355	1	333	4.0e-71	261	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
649947578	529	25.68	121	519	35	413	1.0e-44	174	COG3664	Beta-xylosidase	428
649947579	430	35.88	43	430	10	433	7.0e-71	261	COG5368	Uncharacterized protein	451
649947580	134	43	1	100	1	100	9.0e-20	89.2	COG1188	Ribosomal 50S subunit-recycling heat shock protein, contains S4 domain	100
649947582	504	26.33	34	504	20	450	4.0e-41	162	COG2132	Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA)	451
649947583	276	24.19	4	250	12	257	7.0e-11	61.6	COG0730	Uncharacterized membrane protein YfcA	258
649947584	253	39.5	20	250	16	251	3.0e-46	178	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
649947585	606	62.53	65	480	2	414	0.0e+00	571	COG2895	Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family	431
649947586	316	35.96	8	316	3	261	2.0e-52	199	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
649947588	286	40.74	1	188	1	189	2.0e-42	166	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
649947590	310	23.29	1	289	2	287	1.0e-16	81	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649947591	350	27.69	29	343	2	308	2.0e-33	136	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649947592	592	31.77	7	557	5	542	3.0e-88	319	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
649947593	362	31.58	6	350	2	355	2.0e-59	223	COG0337	3-dehydroquinate synthetase	360
649947594	237	26.48	1	232	2	251	8.0e-17	80.7	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649947597	291	21.95	28	266	7	252	1.0e-24	107	COG2116	Formate/nitrite transporter FocA, FNT family	265
649947598	194	45.56	14	193	1	170	6.0e-44	170	COG1778	 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases	170
649947600	870	34.25	74	420	51	397	2.0e-62	234	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
649947602	1139	22.3	12	844	4	783	6.0e-39	156	COG2374	Predicted extracellular nuclease	798
649947603	708	42.94	157	680	1	500	5.0e-102	365	COG0366	Glycosidase	505
649947606	689	39.91	21	689	14	693	0.0e+00	568	COG1523	Pullulanase/glycogen debranching enzyme	697
649947607	481	35.2	37	481	8	447	5.0e-59	222	COG1538	Outer membrane protein TolC	457
649947608	1076	43.57	1	1031	2	1007	0.0e+00	885	COG0841	Multidrug efflux pump subunit AcrB	1009
649947609	418	25.4	23	397	11	365	4.0e-27	116	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
649947610	260	22.7	28	212	5	186	7.0e-08	51.2	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649947611	508	40.59	45	499	3	475	5.0e-109	388	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649947616	607	24.63	120	494	6	390	6.0e-39	156	COG0366	Glycosidase	505
649947617	744	31.62	2	115	29	143	2.0e-15	78.5	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	148
649947618	470	23.13	30	460	4	411	4.0e-50	192	COG0415	Deoxyribodipyrimidine photolyase	461
649947622	324	42.5	5	315	4	314	6.0e-58	218	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649947623	456	45.73	18	445	8	429	0.0e+00	475	COG0677	UDP-N-acetyl-D-mannosaminuronate dehydrogenase	436
649947625	398	45.01	1	398	1	403	9.0e-118	417	COG2081	Predicted flavoprotein YhiN	408
649947626	423	37.38	23	423	2	393	1.0e-84	307	COG1092	23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI	393
649947627	370	44.35	42	368	28	335	1.0e-99	356	COG0016	Phenylalanyl-tRNA synthetase alpha subunit	335
649947630	420	40.66	1	420	1	386	3.0e-98	352	COG0754	Glutathionylspermidine synthase	387
649947632	379	22.6	5	375	2	378	2.0e-27	117	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649947636	161	48.43	3	161	2	155	1.0e-47	182	COG1225	Peroxiredoxin	157
649947638	340	47.77	1	336	1	310	9.0e-89	320	COG0331	Malonyl CoA-acyl carrier protein transacylase	310
649947639	189	32.54	17	185	19	181	1.0e-18	86.7	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649947645	347	28.69	1	333	12	368	1.0e-22	101	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649947647	106	20.45	1	88	2	85	9.0e-03	32.2	COG3636	DNA-binding prophage protein	100
649947648	829	35.06	63	756	71	723	0.0e+00	471	COG1501	Alpha-glucosidase, glycosyl hydrolase family GH31	772
649947650	146	23.48	8	136	3	130	1.0e-07	49.4	COG1848	Predicted nucleic acid-binding protein, contains PIN domain	140
649947651	554	63.72	4	534	2	533	0.0e+00	866	COG0504	CTP synthase (UTP-ammonia lyase)	533
649947654	163	36.13	33	151	1	112	8.0e-14	69.9	COG0792	Predicted endonuclease distantly related to archaeal Holliday junction resolvase	114
649947656	518	40.82	23	505	3	472	2.0e-120	426	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
649947660	473	36.95	27	448	33	447	3.0e-113	402	COG0160	4-aminobutyrate aminotransferase or related aminotransferase	447
649947661	484	44.94	17	478	23	496	2.0e-125	443	COG1953	Cytosine/uracil/thiamine/allantoin permease	497
649947662	468	35.9	1	453	1	430	2.0e-95	343	COG0044	Dihydroorotase or related cyclic amidohydrolase	430
649947665	489	37.58	4	320	2	310	1.0e-71	264	COG0167	Dihydroorotate dehydrogenase	310
649947666	448	34.82	14	434	1	446	8.0e-82	297	COG0493	NADPH-dependent glutamate synthase beta chain or related oxidoreductase	457
649947668	424	22.61	11	422	14	409	6.0e-26	112	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
649947670	391	41.41	1	96	1	98	4.0e-15	76.1	COG4104	Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, incolved in TypeVI secretion	98
649947675	238	26.82	7	216	4	201	2.0e-16	79.8	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649947678	321	24.29	66	309	2	220	8.0e-17	81.3	COG3039	Transposase and inactivated derivatives, IS5 family	230
649947680	366	60.34	6	358	2	340	0.0e+00	532	COG1088	dTDP-D-glucose 4,6-dehydratase	340
649947681	291	59.03	1	288	1	285	5.0e-116	410	COG1209	dTDP-glucose pyrophosphorylase	286
649947682	300	44.63	1	298	2	280	9.0e-80	290	COG1091	dTDP-4-dehydrorhamnose reductase	281
649947684	184	51.67	1	180	1	173	7.0e-56	210	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase or related enzyme	173
649947686	247	46.34	45	247	36	226	5.0e-59	221	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
649947687	382	21.27	1	346	1	356	2.0e-20	93.5	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649947689	107	39.81	5	107	2	96	7.0e-18	82.2	COG0721	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit	96
649947690	477	52.83	7	474	13	466	0.0e+00	472	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649947692	204	43.87	42	196	31	182	7.0e-40	157	COG3108	Uncharacterized conserved protein YcbK, DUF882 family	185
649947693	209	47.03	6	199	4	205	3.0e-41	161	COG3132	Uncharacterized conserved protein YceH, UPF0502 family	215
649947694	466	16.71	6	418	3	401	1.0e-14	74.8	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
649947695	593	32.21	1	592	2	567	3.0e-94	339	COG0358	DNA primase (bacterial type)	568
649947696	381	37.71	22	375	2	355	4.0e-82	298	COG1363	Putative aminopeptidase FrvX	355
649947698	262	35.12	16	256	4	237	4.0e-42	165	COG0565	tRNA C32,U32 (ribose-2'-O)-methylase TrmJ or a related methyltransferase	242
649947699	810	20.83	164	777	13	620	4.0e-42	166	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
649947701	190	42.71	1	190	11	209	2.0e-41	162	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649947702	384	25.85	38	375	14	364	2.0e-38	153	COG4585	Signal transduction histidine kinase	365
649947703	268	18.62	22	265	38	283	2.0e-09	56.5	COG0842	ABC-type multidrug transport system, permease component	286
649947704	309	36.49	19	305	4	291	6.0e-61	227	COG1131	ABC-type multidrug transport system, ATPase component	293
649947706	436	29.52	8	380	2	354	4.0e-47	182	COG0389	Nucleotidyltransferase/DNA polymerase involved in DNA repair	354
649947711	611	31.56	27	600	95	724	1.0e-118	421	COG0058	Glucan phosphorylase	750
649947712	158	28.57	1	158	1	162	8.0e-18	83	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
649947713	554	23.74	31	403	2	414	7.0e-35	142	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
649947714	310	36.54	3	303	1	306	7.0e-39	154	COG0524	Sugar or nucleoside kinase, ribokinase family	311
649947715	1118	36.09	12	1087	2	1009	0.0e+00	883	COG0841	Multidrug efflux pump subunit AcrB	1009
649947716	1062	36.59	4	1033	3	1009	0.0e+00	936	COG0841	Multidrug efflux pump subunit AcrB	1009
649947717	500	32.25	68	370	22	323	4.0e-25	109	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
649947718	495	24.68	194	495	8	289	2.0e-24	107	COG0382	4-hydroxybenzoate polyprenyltransferase	289
649947721	365	56.87	55	365	3	314	2.0e-116	412	COG0462	Phosphoribosylpyrophosphate synthetase	314
649947722	232	36.9	18	101	12	93	2.0e-12	66.4	COG1825	Ribosomal protein L25 (general stress protein Ctc)	93
649947723	206	38.78	1	195	2	190	2.0e-50	191	COG0193	Peptidyl-tRNA hydrolase	190
649947724	162	40.19	3	109	1	107	9.0e-26	109	COG0360	Ribosomal protein S6	112
649947725	129	58.21	57	123	9	75	5.0e-21	93.4	COG0238	Ribosomal protein S18	75
649947726	158	45.27	1	148	1	148	1.0e-35	142	COG0359	Ribosomal protein L9	148
649947727	287	41.76	3	183	7	188	3.0e-43	168	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
649947728	201	21.58	14	201	5	194	6.0e-07	47.7	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649947729	710	32.79	57	706	2	644	4.0e-121	429	COG1505	Prolyl oligopeptidase PreP, S9A serine peptidase family	648
649947730	323	17.79	74	322	3	243	4.0e-07	49	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
649947731	187	31.25	16	175	17	176	6.0e-19	87.4	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649947732	584	46.31	26	576	15	532	0.0e+00	514	COG0405	Gamma-glutamyltranspeptidase	539
649947733	300	24.83	3	280	2	258	3.0e-17	83	COG1082	Sugar phosphate isomerase/epimerase	274
649947734	444	48.64	7	444	4	435	0.0e+00	521	COG0017	Aspartyl/asparaginyl-tRNA synthetase	435
649947735	186	27.01	1	186	1	204	6.0e-19	87.4	COG0288	Carbonic anhydrase	207
649947736	226	23.23	22	216	29	220	6.0e-13	68	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
649947737	314	37.25	8	303	6	297	4.0e-39	155	COG0583	DNA-binding transcriptional regulator, LysR family	297
649947738	348	31.77	43	339	31	328	3.0e-45	176	COG2855	Uncharacterized membrane protein YadS	334
649947739	280	34.19	1	280	1	310	6.0e-63	234	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
649947740	232	31.8	3	215	1	212	1.0e-30	127	COG2930	Lipid-binding SYLF domain	227
649947742	372	41.85	4	357	1	316	1.0e-84	306	COG1181	D-alanine-D-alanine ligase and related ATP-grasp enzymes	317
649947743	454	45.4	244	416	9	181	4.0e-37	149	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
649947744	225	33.33	59	223	42	186	1.0e-16	80.1	COG3544	Uncharacterized conserved protein, DUF305 family	190
649947746	182	43.18	6	179	3	175	6.0e-41	160	COG4502	5'(3')-deoxyribonucleotidase	180
649947747	261	23.83	1	234	2	234	4.0e-17	81.9	COG1579	Predicted  nucleic acid-binding protein, contains Zn-ribbon domain	239
649947750	399	15.92	109	393	1	305	1.0e-10	61.5	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
649947751	348	38.12	32	338	4	315	5.0e-60	225	COG3940	Beta-xylosidase, GH43 family	324
649947752	292	59.93	4	290	2	287	7.0e-117	413	COG1210	UTP-glucose-1-phosphate uridylyltransferase	291
649947753	592	19.28	13	581	1	579	5.0e-27	116	COG4805	Uncharacterized conserved protein, DUF885 familyt	588
649947754	288	22.77	52	253	15	236	1.0e-15	77.2	COG1082	Sugar phosphate isomerase/epimerase	274
649947755	292	23.28	28	181	11	199	5.0e-07	48.8	COG2514	Catechol-2,3-dioxygenase	265
649947758	1233	42.71	29	1159	8	1096	0.0e+00	1096	COG1197	Transcription-repair coupling factor (superfamily II helicase)	1139
649947761	262	35.14	72	256	1	175	1.0e-26	114	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649947769	593	36.96	65	386	106	453	2.0e-91	330	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
649947770	351	21.27	1	347	16	409	1.0e-24	107	COG2124	Cytochrome P450	411
649947771	352	24.07	42	310	18	311	5.0e-20	92	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
649947772	571	23.51	140	535	14	374	4.0e-18	86.9	COG2234	Zn-dependent amino- or carboxypeptidase, M28 family	435
649947775	496	23.35	36	485	8	443	1.0e-26	114	COG1538	Outer membrane protein TolC	457
649947777	332	41.43	3	320	1	316	4.0e-88	318	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
649947778	371	22.34	17	371	26	408	1.0e-23	104	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
649947779	241	52.73	22	239	1	220	5.0e-77	280	COG1136	ABC-type lipoprotein export system, ATPase component	226
649947780	241	23.81	8	208	4	213	9.0e-15	74.1	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649947783	375	19.83	17	374	18	368	2.0e-22	100	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649947784	625	26.06	7	599	6	547	1.0e-71	264	COG2989	Murein L,D-transpeptidase YcbB/YkuD	561
649947787	341	28.13	6	328	3	303	9.0e-27	114	COG3547	Transposase	303
649947792	414	52.15	5	350	1	347	1.0e-108	387	COG1171	Threonine dehydratase	347
649947793	212	31.6	1	211	1	195	3.0e-31	128	COG0237	Dephospho-CoA kinase	201
649947794	309	52.32	5	304	1	280	7.0e-98	350	COG0190	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	283
649947795	53	47.73	9	50	7	50	4.0e-07	46.4	COG2835	Uncharacterized conserved protein YbaR, Trm112 family	60
649947797	908	31.35	76	360	8	290	3.0e-38	154	COG1752	Predicted acylesterase/phospholipase RssA, containd patatin domain	306
649947798	931	40.08	22	931	2	910	0.0e+00	725	COG2352	Phosphoenolpyruvate carboxylase	910
649947799	137	29.55	1	132	2	124	1.0e-14	72.1	COG1487	Predicted nucleic acid-binding protein, contains PIN domain	133
649947801	376	40.23	16	351	10	339	1.0e-73	270	COG1194	Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs	342
649947802	141	37.59	5	139	4	143	2.0e-22	98.5	COG1764	Organic hydroperoxide reductase OsmC/OhrA	143
649947804	317	41.67	2	288	11	296	5.0e-63	234	COG1230	Co/Zn/Cd efflux system component	296
649947807	211	68.54	33	210	5	177	2.0e-68	251	COG5405	ATP-dependent protease HslVU (ClpYQ), peptidase subunit	178
649947809	545	52.26	16	545	1	444	0.0e+00	590	COG1220	ATP-dependent protease HslVU (ClpYQ), ATPase subunit	444
649947811	353	33.24	2	340	115	433	2.0e-52	199	COG1793	ATP-dependent DNA ligase	444
649947812	468	42.33	10	306	2	299	4.0e-76	279	COG3285	Eukaryotic-type DNA primase	299
649947814	207	39.22	4	204	6	205	3.0e-35	141	COG0522	Ribosomal protein S4 or related protein	205
649947816	214	27.01	3	171	1	166	3.0e-18	85.4	COG2184	Fido, protein-threonine AMPylation domain	201
649947820	618	25.29	24	608	18	620	1.0e-67	251	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
649947821	216	18.04	7	200	4	195	4.0e-06	45	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649947824	330	36.36	5	319	1	239	2.0e-60	226	COG0176	Transaldolase	239
649947828	397	36.04	1	391	2	350	4.0e-75	275	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
649947829	302	20	26	302	10	282	4.0e-20	92.5	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649947831	203	55.83	1	203	2	203	3.0e-74	271	COG0605	Superoxide dismutase	204
649947832	826	21.97	39	700	3	612	5.0e-63	236	COG3387	Glucoamylase (glucan-1,4-alpha-glucosidase), GH15 family	612
649947833	665	55.49	8	664	4	663	0.0e+00	911	COG0021	Transketolase	663
649947835	223	55.91	1	217	1	220	2.0e-70	258	COG0120	Ribose 5-phosphate isomerase	227
649947837	303	44.39	6	191	3	189	3.0e-44	172	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
649947838	213	23.39	4	211	3	220	1.0e-14	73	COG1011	FMN phosphatase YigB, HAD superfamily	229
649947839	516	49.2	19	515	1	482	0.0e+00	646	COG0364	Glucose-6-phosphate 1-dehydrogenase	483
649947840	263	38.49	17	250	11	238	7.0e-53	200	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	238
649947841	349	35.76	2	331	8	319	2.0e-73	269	COG0837	Glucokinase	320
649947843	846	26.68	26	823	19	846	2.0e-115	410	COG0308	Aminopeptidase N	859
649947844	186	38.12	8	185	6	179	5.0e-40	157	COG0241	Histidinol phosphatase or a related phosphatase	181
649947845	356	27.19	5	334	3	332	9.0e-36	144	COG0859	ADP-heptose:LPS heptosyltransferase	334
649947848	180	33.33	36	163	5	130	1.0e-17	83.4	COG1664	Cytoskeletal protein CcmA, bactofilin family	146
649947853	578	24.18	24	555	69	531	7.0e-49	189	COG5434	Polygalacturonase	542
649947855	490	35.37	51	489	16	453	2.0e-64	240	COG1538	Outer membrane protein TolC	457
649947856	437	28.84	55	428	6	371	2.0e-27	117	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
649947857	1062	29.01	2	1037	1	1006	0.0e+00	654	COG0841	Multidrug efflux pump subunit AcrB	1009
649947858	302	30.13	1	298	1	296	3.0e-36	145	COG0583	DNA-binding transcriptional regulator, LysR family	297
649947860	543	38.08	12	510	1	498	4.0e-82	299	COG0366	Glycosidase	505
649947863	60	32.14	4	59	1	56	2.0e-05	41	COG3847	Flp pilus assembly protein, pilin Flp	58
649947864	182	27.33	14	173	13	159	9.0e-11	60.2	COG4960	Flp pilus assembly protein, protease CpaA	168
649947865	291	29.41	1	238	1	253	3.0e-27	115	COG3745	Flp pilus assembly protein CpaB	276
649947866	484	32.46	30	472	2	432	6.0e-71	262	COG4964	Flp pilus assembly protein, secretin CpaC	455
649947867	417	26.97	150	415	104	364	7.0e-27	115	COG4963	Flp pilus assembly protein, ATPase CpaE	366
649947868	452	55.14	61	410	9	353	2.0e-115	409	COG4962	Pilus assembly protein, ATPase of CpaF family	355
649947869	320	29.69	1	320	1	309	4.0e-41	161	COG4965	Flp pilus assembly protein TadB	309
649947871	224	28.71	4	206	2	210	6.0e-25	107	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649947872	60	32.73	5	59	2	56	2.0e-05	40.6	COG3847	Flp pilus assembly protein, pilin Flp	58
649947874	60	41.82	5	59	2	56	1.0e-05	41.8	COG3847	Flp pilus assembly protein, pilin Flp	58
649947875	129	30.43	21	128	9	121	3.0e-10	57.6	COG1430	Uncharacterized conserved membrane protein, UPF0127 family	126
649947876	820	44.44	553	803	3	252	1.0e-67	251	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
649947878	397	45.93	213	383	11	181	2.0e-39	157	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
649947879	354	28.93	1	296	30	328	5.0e-34	138	COG3673	Uncharacterized protein, PA2063/DUF2235 family	423
649947883	266	35.77	26	260	2	245	5.0e-41	161	COG1801	Uncharacterized conserved protein YecE, DUF72 family	263
649947884	338	31.25	5	334	15	337	2.0e-53	203	COG0429	Predicted hydrolase of the alpha/beta-hydrolase fold	345
649947889	518	31.01	3	414	1	393	4.0e-56	212	COG1696	D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily	425
649947890	599	34.71	21	595	4	574	1.0e-109	390	COG3882	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis	574
649947891	82	23.75	1	80	1	80	4.0e-07	46.5	COG0236	Acyl carrier protein	80
649947893	246	28.29	1	243	3	249	5.0e-25	108	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649947896	281	34.22	33	252	17	239	2.0e-44	172	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
649947900	568	26.38	48	567	14	449	7.0e-45	175	COG2132	Multicopper oxidase with three cupredoxin domains (includes cell division protein FtsP and spore coat protein CotA)	451
649947904	417	24.36	8	394	1	380	2.0e-24	107	COG2814	Predicted arabinose efflux permease, MFS family	394
649947905	387	44.16	12	386	5	389	1.0e-86	313	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
649947908	715	17.36	23	712	7	662	6.0e-20	93.2	COG1289	Uncharacterized membrane protein YccC	674
649947909	428	21.94	92	405	42	318	6.0e-16	79	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947912	354	25.07	1	346	7	318	3.0e-19	89.7	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947913	323	25.98	5	315	13	318	6.0e-26	111	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947914	366	22.49	1	357	1	317	4.0e-17	82.4	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947915	382	22.12	51	374	28	318	1.0e-20	94.4	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947916	438	50.86	12	412	2	400	8.0e-97	347	COG1301	Na+/H+-dicarboxylate symporter	415
649947917	320	22.67	1	310	14	316	7.0e-23	101	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947918	375	22.11	76	367	49	318	3.0e-16	80.1	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947919	164	41.45	10	161	22	169	4.0e-34	137	COG0684	Regulator of RNase E activity RraA	210
649947920	805	20.35	457	775	30	318	5.0e-14	73.6	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947921	348	25.89	46	312	31	310	1.0e-12	67.5	COG3391	DNA-binding beta-propeller fold protein YncE	381
649947922	481	27.58	66	479	44	443	3.0e-26	113	COG1538	Outer membrane protein TolC	457
649947924	1060	30.72	27	1029	15	1004	0.0e+00	636	COG0841	Multidrug efflux pump subunit AcrB	1009
649947926	226	45.61	1	222	1	227	4.0e-60	224	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649947927	483	36.62	160	470	30	334	4.0e-48	186	COG0642	Signal transduction histidine kinase	336
649947929	472	42.95	24	467	1	446	2.0e-96	346	COG2031	Short chain fatty acids transporter	446
649947930	466	30.7	141	466	16	335	8.0e-35	141	COG0642	Signal transduction histidine kinase	336
649947931	370	18.47	16	357	3	313	1.0e-08	54.7	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947932	404	25.97	73	367	43	316	4.0e-17	82.8	COG0226	ABC-type phosphate transport system, periplasmic component	318
649947934	485	30.02	27	411	65	448	5.0e-35	142	COG5434	Polygalacturonase	542
649947936	818	35.83	563	802	19	227	3.0e-40	160	COG0860	N-acetylmuramoyl-L-alanine amidase	231
649947937	941	47.52	5	940	7	879	0.0e+00	954	COG0013	Alanyl-tRNA synthetase	879
649947938	79	21.62	1	74	2	73	4.0e-06	43.1	COG4118	Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor	84
649947939	152	26.47	6	140	3	138	8.0e-17	79.6	COG5573	Predicted nucleic acid-binding protein, contains PIN domain	142
649947942	185	31.06	14	174	19	172	2.0e-14	72.2	COG2137	SOS response regulatory protein OraA/RecX, interacts with RecA	174
649947943	802	24.17	38	792	1	616	5.0e-78	286	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
649947946	218	32.31	54	182	1	127	4.0e-12	65	COG1403	5-methylcytosine-specific restriction endonuclease McrA	146
649947947	239	37.02	1	207	25	223	5.0e-35	141	COG1040	Predicted amidophosphoribosyltransferases	225
649947948	792	33.67	6	488	1	479	5.0e-80	292	COG1297	Uncharacterized membrane protein, oligopeptide transporter (OPT) family	624
649947950	316	25.08	3	300	1	292	1.0e-10	61	COG0697	Permease of the drug/metabolite transporter (DMT) superfamily	292
649947952	355	43.92	22	355	2	322	3.0e-88	319	COG2896	Molybdenum cofactor biosynthesis enzyme MoaA	322
649947953	363	33.16	152	340	2	180	1.0e-30	127	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
649947960	230	27.05	13	215	21	201	5.0e-04	38.4	COG1994	Zn-dependent protease (includes SpoIVFB)	230
649947961	396	40.92	6	369	2	314	7.0e-98	351	COG0180	Tryptophanyl-tRNA synthetase	314
649947962	308	31.8	63	298	11	247	5.0e-32	132	COG1354	Chromatin segregation and condensation protein Rec8/ScpA/Scc1, kleisin family	248
649947965	355	45.21	128	273	42	184	1.0e-29	123	COG1386	Chromosome segregation and condensation protein ScpB	184
649947967	131	34.65	1	125	6	131	5.0e-18	83.3	COG1917	Cupin domain protein related to quercetin dioxygenase	131
649947968	312	43.46	23	279	2	248	4.0e-64	238	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
649947969	426	26.27	9	413	4	418	6.0e-49	188	COG1055	Na+/H+ antiporter NhaD or related arsenite permease	424
649947972	208	44.55	5	207	1	211	3.0e-50	191	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649947975	352	22.71	27	337	19	313	3.0e-22	99.7	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
649947976	646	27.56	1	192	1	221	7.0e-22	99.6	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
649947977	489	22.01	18	478	31	489	4.0e-33	136	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
649947978	330	17.55	134	300	52	227	6.0e-10	58.7	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
649947980	469	28.57	25	397	29	412	2.0e-35	143	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
649947981	503	24.31	39	453	29	449	9.0e-35	142	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
649947982	500	25.6	21	383	30	402	8.0e-35	142	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
649947983	509	20.67	25	457	30	467	9.0e-39	155	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
649947986	282	33.47	3	243	4	242	4.0e-47	181	COG1922	UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family	253
649947987	387	21.58	1	366	1	378	1.0e-25	110	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649947988	290	21.27	6	271	1	259	2.0e-17	83.7	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649947989	400	18.75	35	393	28	411	6.0e-05	42.4	COG3307	O-antigen ligase	424
649947990	437	20.28	1	423	5	414	3.0e-15	76.7	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
649947992	989	32.58	302	474	43	219	1.0e-21	99.4	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
649947994	156	29.36	48	152	15	111	4.0e-05	40.7	COG2863	Cytochrome c553	121
649947997	334	21.76	151	314	2	164	2.0e-07	50.3	COG1853	NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family	176
649948000	604	26.4	259	575	21	327	5.0e-29	122	COG0642	Signal transduction histidine kinase	336
649948001	243	42.74	4	243	3	229	7.0e-59	220	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649948007	540	28.68	278	534	93	363	4.0e-34	139	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
649948009	742	29.68	34	289	2	281	2.0e-35	144	COG0515	Serine/threonine protein kinase	384
649948014	276	33.33	24	243	17	239	1.0e-43	170	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
649948015	385	27.22	21	363	2	367	2.0e-53	203	COG2021	Homoserine acetyltransferase	368
649948016	505	37.2	22	500	4	475	4.0e-98	352	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649948018	522	30.8	73	515	1	426	2.0e-69	256	COG3669	Alpha-L-fucosidase	430
649948019	297	18.86	57	280	9	211	1.0e-11	64.6	COG2755	Lysophospholipase L1 or related esterase	216
649948020	411	27.68	86	401	26	357	1.0e-41	164	COG4225	Rhamnogalacturonyl hydrolase YesR	357
649948021	440	19.21	183	398	3	211	5.0e-15	75.7	COG2755	Lysophospholipase L1 or related esterase	216
649948022	270	20.7	42	258	6	211	4.0e-10	58.8	COG2755	Lysophospholipase L1 or related esterase	216
649948025	492	46.98	14	472	7	459	0.0e+00	495	COG1139	L-lactate utilization protein LutB, contains a ferredoxin-type domain	459
649948026	228	29	8	226	2	216	8.0e-23	100	COG1556	L-lactate utilization protein LutC, contains LUD domain	218
649948027	401	38.78	12	396	38	426	2.0e-104	372	COG4952	L-rhamnose isomerase	430
649948028	362	24.75	71	360	28	313	9.0e-24	104	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
649948029	734	37.14	9	454	1	404	3.0e-109	390	COG3347	Rhamnose utilisation protein RhaD, predicted bifunctional aldolase and dehydrogenase	404
649948030	480	20.42	8	474	4	474	4.0e-47	182	COG1070	Sugar (pentulose or hexulose) kinase	502
649948039	727	21.83	4	725	2	768	2.0e-83	304	COG2366	Acyl-homoserine lactone (AHL) acylase PvdQ	768
649948042	146	28.16	31	133	5	93	3.0e-13	67.7	COG3536	Uncharacterized conserved protein, DUF971 family	120
649948043	262	25.1	11	261	7	253	3.0e-12	65.8	COG0730	Uncharacterized membrane protein YfcA	258
649948045	632	30.65	144	630	3	475	3.0e-77	283	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649948046	607	49.09	11	605	2	584	0.0e+00	735	COG0173	Aspartyl-tRNA synthetase	585
649948047	211	23.27	12	169	4	162	1.0e-06	47	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649948048	296	25.74	1	283	1	294	1.0e-19	90.4	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649948049	232	32.71	16	225	13	222	2.0e-27	115	COG3619	Uncharacterized membrane protein YoaK, UPF0700 family	226
649948051	450	22.65	79	432	41	429	1.0e-31	131	COG1524	Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily	450
649948052	162	30	4	148	3	150	2.0e-09	55.5	COG3652	Predicted outer membrane protein	170
649948054	572	18.86	159	540	82	439	1.0e-27	118	COG1232	Protoporphyrinogen oxidase	444
649948056	319	29.54	75	302	14	218	2.0e-24	106	COG4117	Thiosulfate reductase cytochrome b subunit	221
649948059	602	38.54	7	579	1	586	0.0e+00	499	COG4805	Uncharacterized conserved protein, DUF885 familyt	588
649948061	282	45.61	1	282	1	277	1.0e-63	236	COG2890	Methylase of polypeptide chain release factors	280
649948064	358	58.31	1	352	5	358	0.0e+00	484	COG0216	Protein chain release factor A	363
649948065	668	27.34	73	642	1	443	2.0e-51	197	COG1793	ATP-dependent DNA ligase	444
649948066	406	66.16	14	406	7	395	0.0e+00	622	COG0133	Tryptophan synthase beta chain	396
649948067	254	45.97	7	254	15	262	8.0e-74	270	COG0159	Tryptophan synthase alpha chain	265
649948068	85	31.03	1	85	8	94	1.0e-10	58	COG1605	Chorismate mutase	101
649948069	339	57.14	64	336	14	286	2.0e-101	362	COG2876	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	286
649948071	200	38.8	19	198	21	196	7.0e-36	143	COG2184	Fido, protein-threonine AMPylation domain	201
649948072	283	32.29	5	282	6	278	2.0e-45	175	COG0287	Prephenate dehydrogenase	279
649948074	149	30.97	21	133	1	113	2.0e-10	58.4	COG1846	DNA-binding transcriptional regulator, MarR family	126
649948076	416	40.29	71	404	23	340	3.0e-57	216	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
649948078	345	23	113	302	6	200	3.0e-07	49.6	COG1994	Zn-dependent protease (includes SpoIVFB)	230
649948079	187	32.22	11	186	10	188	3.0e-31	127	COG0797	Rare lipoprotein A, peptidoglycan hydrolase digesting "naked" glycans, contains C-terminal SPOR domain	233
649948080	271	40.91	9	266	1	249	3.0e-39	155	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948082	177	55.41	20	165	1	147	4.0e-46	177	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
649948083	261	53.99	1	261	4	260	2.0e-85	308	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	260
649948086	288	34.75	8	286	5	275	7.0e-52	197	COG3494	Uncharacterized conserved protein, DUF1009 family	279
649948087	183	48.03	32	180	3	154	5.0e-45	173	COG1225	Peroxiredoxin	157
649948089	600	67.67	1	600	4	603	0.0e+00	1018	COG0481	Translation elongation factor EF-4, membrane-bound GTPase	603
649948090	217	22.58	35	187	19	169	8.0e-10	57.3	COG2825	Periplasmic chaperone for outer membrane proteins, Skp family	170
649948092	109	37.5	2	109	1	112	7.0e-26	108	COG0537	Diadenosine tetraphosphate (Ap4A) hydrolase or other HIT family hydrolase	138
649948093	439	19.24	150	430	26	301	6.0e-15	75.7	COG0501	Zn-dependent protease with chaperone function	302
649948094	248	43.6	3	245	2	249	4.0e-47	181	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948095	598	24.35	178	550	75	437	3.0e-29	123	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
649948096	560	20.79	155	546	74	454	8.0e-20	92.4	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
649948097	407	25.15	74	407	37	364	4.0e-15	76.3	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
649948098	1045	39.71	1	1031	1	1020	0.0e+00	954	COG3696	Cu/Ag efflux pump CusA	1027
649948099	439	25.78	9	435	1	444	3.0e-26	113	COG1538	Outer membrane protein TolC	457
649948104	353	45.58	3	353	4	352	2.0e-99	356	COG3424	Predicted naringenin-chalcone synthase	356
649948105	83	38.46	1	77	3	80	5.0e-08	49.5	COG0236	Acyl carrier protein	80
649948107	399	39.76	1	397	2	409	1.0e-86	313	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
649948108	272	19.3	1	272	4	284	6.0e-09	54.8	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649948109	693	52.79	16	517	1	496	0.0e+00	669	COG0753	Catalase	496
649948110	579	26.16	16	326	20	348	1.0e-23	105	COG3240	Phospholipase/lecithinase/hemolysin	370
649948111	655	50.15	1	655	1	597	0.0e+00	732	COG0449	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains	597
649948113	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649948114	321	24.29	66	309	2	220	4.0e-17	82.5	COG3039	Transposase and inactivated derivatives, IS5 family	230
649948121	939	12.08	91	787	19	705	4.0e-08	54.5	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
649948122	194	35.33	12	194	19	195	5.0e-28	117	COG5516	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding	196
649948123	288	26.39	5	285	1	282	4.0e-20	92.1	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649948124	218	39.59	6	196	2	194	6.0e-55	207	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	194
649948126	218	38.05	1	199	1	193	9.0e-58	216	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	194
649948127	319	36.84	16	315	2	291	7.0e-55	207	COG0384	Predicted epimerase YddE/YHI9, PhzF superfamily	291
649948128	154	31.78	1	124	2	128	6.0e-11	60.2	COG0784	CheY chemotaxis protein or a CheY-like REC (receiver) domain	130
649948129	779	42.9	6	750	9	662	0.0e+00	687	COG1200	RecG-like helicase	677
649948130	99	35.35	1	99	3	100	7.0e-19	85.4	COG3636	DNA-binding prophage protein	100
649948131	114	47.37	6	100	2	96	5.0e-32	129	COG3657	Putative component of the toxin-antitoxin plasmid stabilization module	100
649948132	302	42	3	300	1	299	9.0e-90	323	COG4152	ABC-type uncharacterized transport system, ATPase component	300
649948133	413	23.44	6	408	2	403	7.0e-28	118	COG1668	ABC-type Na+ efflux pump, permease component	407
649948134	219	34.83	6	182	7	181	6.0e-35	140	COG2121	Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily	214
649948135	368	49.32	1	367	1	342	2.0e-122	432	COG0809	S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)	348
649948136	975	45.01	395	975	26	593	0.0e+00	566	COG0749	DNA polymerase I - 3'-5' exonuclease and polymerase domains	593
649948140	484	51.84	17	476	4	420	0.0e+00	629	COG0499	S-adenosylhomocysteine hydrolase	420
649948142	75	58.73	5	66	3	65	1.0e-19	88.3	COG1278	Cold shock protein, CspA family	67
649948148	321	36.92	1	321	2	326	2.0e-73	269	COG1171	Threonine dehydratase	347
649948149	374	25.14	30	371	2	342	2.0e-30	127	COG0673	Predicted dehydrogenase	342
649948150	183	40.71	71	182	1	101	2.0e-18	85.3	COG4818	Uncharacterized membrane protein	105
649948152	451	22.79	19	451	20	447	2.0e-23	103	COG2271	Sugar phosphate permease	448
649948154	370	44.2	26	206	12	187	7.0e-44	171	COG2169	Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains	187
649948155	286	29.08	1	259	11	288	2.0e-27	116	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
649948157	831	35.48	57	830	6	795	0.0e+00	634	COG5009	Membrane carboxypeptidase/penicillin-binding protein	797
649948158	389	70.57	4	380	2	384	0.0e+00	661	COG0192	S-adenosylmethionine synthetase	388
649948159	381	25.75	20	368	15	368	9.0e-19	88.3	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649948162	310	29.37	43	307	2	231	1.0e-23	103	COG0412	Dienelactone hydrolase	236
649948165	254	39.09	10	229	16	227	2.0e-40	159	COG2013	Uncharacterized conserved protein, AIM24 family	227
649948166	806	21.02	41	620	15	595	4.0e-50	193	COG3250	Beta-galactosidase/beta-glucuronidase	808
649948169	113	43.18	5	92	5	91	2.0e-18	84.2	COG2827	Predicted endonuclease, GIY-YIG superfamily	95
649948170	587	34.47	8	502	2	480	1.0e-105	377	COG0514	Superfamily II DNA helicase RecQ	590
649948172	234	59.57	1	234	4	238	2.0e-86	311	COG0528	Uridylate kinase	238
649948174	348	21.73	1	345	30	367	9.0e-14	71.4	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649948176	430	21.99	34	365	53	342	1.0e-15	77.6	COG2706	6-phosphogluconolactonase, cycloisomerase 2 family	346
649948177	415	21.75	37	404	7	340	1.0e-09	58.4	COG2706	6-phosphogluconolactonase, cycloisomerase 2 family	346
649948178	699	41.35	42	699	6	654	0.0e+00	625	COG3590	Predicted metalloendopeptidase	654
649948179	361	22.29	14	320	10	302	2.0e-16	80.1	COG1463	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, periplasmic component MlaD	359
649948180	125	49.6	1	125	1	125	1.0e-35	141	COG0736	Phosphopantetheinyl transferase (holo-ACP synthase)	127
649948187	187	32.56	1	170	3	172	4.0e-26	111	COG3040	Bacterial lipocalin	174
649948188	673	26.76	98	375	49	283	2.0e-10	61.1	COG3458	Cephalosporin-C deacetylase or related acetyl esterase	321
649948190	326	28.48	1	293	1	287	3.0e-49	189	COG1131	ABC-type multidrug transport system, ATPase component	293
649948192	155	31.71	32	153	6	126	3.0e-08	51.5	COG1846	DNA-binding transcriptional regulator, MarR family	126
649948193	1149	21.77	103	768	122	649	8.0e-75	276	COG0209	Ribonucleotide reductase alpha subunit	696
649948195	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649948197	430	17.24	29	418	19	392	2.0e-08	53.9	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
649948198	249	25.54	24	244	1	229	9.0e-25	107	COG0489	Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster	265
649948199	593	37.26	20	588	4	567	5.0e-111	395	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
649948202	170	51.52	3	166	26	190	4.0e-55	207	COG0529	Adenylylsulfate kinase or related kinase	197
649948209	580	14.9	87	556	104	542	2.0e-08	54.3	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	542
649948210	157	48.34	6	156	3	153	2.0e-40	158	COG4119	Predicted NTP pyrophosphohydrolase, NUDIX family	161
649948211	247	42.29	2	247	9	260	3.0e-75	275	COG0708	Exonuclease III	261
649948213	368	52.33	17	353	1	343	1.0e-88	320	COG0389	Nucleotidyltransferase/DNA polymerase involved in DNA repair	354
649948215	191	44.25	6	179	1	170	4.0e-44	171	COG1778	 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases	170
649948216	1538	35.13	15	904	9	793	0.0e+00	646	COG1201	Lhr-like helicase	814
649948222	236	28.38	9	236	1	228	2.0e-15	75.8	COG1814	Predicted Fe2+/Mn2+ transporter, VIT1/CCC1 family	229
649948223	312	26.64	57	310	1	248	2.0e-30	126	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
649948226	261	38.46	21	261	8	253	7.0e-44	170	COG0805	Sec-independent protein secretion pathway component TatC	255
649948227	182	30.3	1	66	3	68	6.0e-08	50.7	COG1826	Sec-independent protein translocase protein TatA	94
649948228	387	38	28	375	16	322	3.0e-88	318	COG0379	Quinolinate synthase	324
649948229	142	24.43	3	133	2	114	8.0e-08	49.6	COG4911	Uncharacterized protein	123
649948232	438	26.77	153	437	26	313	2.0e-30	127	COG1262	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain	314
649948233	328	45.28	19	325	25	319	2.0e-72	266	COG4301	Uncharacterized conserved protein, contains predicted SAM-dependent methyltransferase domain	321
649948235	161	54.14	5	158	1	157	3.0e-46	177	COG0315	Molybdenum cofactor biosynthesis enzyme	157
649948236	401	43.67	1	399	3	399	1.0e-87	316	COG0303	Molybdopterin biosynthesis enzyme	404
649948238	231	47.58	1	225	2	219	8.0e-63	233	COG0603	7-cyano-7-deazaguanine synthase (queuosine biosynthesis)	222
649948242	340	26.61	4	335	1	334	1.0e-45	177	COG0859	ADP-heptose:LPS heptosyltransferase	334
649948243	327	37.35	2	308	12	331	3.0e-54	205	COG1663	Tetraacyldisaccharide-1-P 4'-kinase	336
649948244	431	38.34	2	426	1	419	1.0e-85	311	COG1519	3-deoxy-D-manno-octulosonic-acid transferase	419
649948246	165	25	1	137	9	148	2.0e-08	51.9	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
649948249	446	54.73	2	443	4	437	0.0e+00	582	COG1206	Folate-dependent tRNA-U54 methylase TrmFO/GidA	439
649948251	622	43.09	138	621	2	444	1.0e-128	453	COG1160	Predicted GTPases	444
649948253	696	33.53	25	690	1	651	3.0e-120	426	COG1199	Rad3-related DNA helicase	654
649948255	236	28.44	1	217	7	211	4.0e-18	85.3	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
649948256	125	38.4	1	125	2	126	5.0e-27	113	COG0720	6-pyruvoyl-tetrahydropterin synthase	127
649948257	227	28.63	1	220	4	210	2.0e-32	132	COG0602	Organic radical activating enzyme	212
649948258	319	35.53	2	314	36	335	2.0e-59	222	COG5042	Purine nucleoside permease	349
649948259	396	21.82	39	313	5	269	5.0e-15	75.9	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649948260	262	21.8	13	217	36	236	9.0e-12	64.2	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
649948261	506	31.01	1	499	4	486	5.0e-74	272	COG1233	Phytoene dehydrogenase-related protein	487
649948262	483	30.53	2	436	27	470	6.0e-66	245	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
649948263	518	32.86	8	493	6	482	6.0e-84	305	COG1233	Phytoene dehydrogenase-related protein	487
649948264	830	49.19	450	808	2	370	0.0e+00	465	COG0562	UDP-galactopyranose mutase	374
649948266	400	17.5	24	286	7	277	5.0e-07	49.4	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649948267	596	21.49	53	365	41	364	8.0e-15	76	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
649948268	377	20.05	40	352	63	432	7.0e-13	68.7	COG2723	Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase	460
649948273	784	37	72	457	1	378	4.0e-75	276	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
649948275	460	41.44	269	449	7	180	3.0e-40	159	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
649948276	322	33.23	3	311	1	296	9.0e-60	224	COG1090	NAD dependent epimerase/dehydratase family enzyme	297
649948279	166	30.36	1	165	1	158	3.0e-22	97.7	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
649948280	453	36.9	37	453	11	390	5.0e-86	311	COG1473	Metal-dependent amidase/aminoacylase/carboxypeptidase	392
649948281	172	21.58	23	159	37	173	1.0e-04	39.5	COG3216	Uncharacterized conserved protein, DUF2062 family	184
649948283	343	27.52	6	328	3	303	7.0e-29	121	COG3547	Transposase	303
649948285	464	46.67	1	464	4	460	0.0e+00	464	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
649948286	793	24.58	19	778	8	711	9.0e-83	301	COG5000	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	712
649948287	370	62.7	1	370	1	370	0.0e+00	502	COG0686	Alanine dehydrogenase	371
649948288	354	60.95	19	351	1	338	2.0e-118	419	COG1077	Actin-like ATPase involved in cell morphogenesis	342
649948289	350	30.37	89	348	51	297	2.0e-27	116	COG2382	Enterochelin esterase or related enzyme	299
649948291	457	28.95	15	456	4	411	4.0e-49	189	COG2124	Cytochrome P450	411
649948292	415	29.93	6	277	2	268	1.0e-33	137	COG1792	Cell shape-determining protein MreC	284
649948293	174	18.3	21	173	10	159	3.0e-03	35.2	COG2891	Cell shape-determining protein MreD	167
649948294	634	30.95	26	605	23	595	5.0e-116	412	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
649948296	171	16.86	1	171	9	173	1.0e-06	46.2	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
649948297	366	40.6	8	366	12	375	5.0e-69	255	COG0772	Bacterial cell division protein FtsW, lipid II flippase	381
649948298	329	23.13	32	300	30	287	1.0e-18	87.7	COG0657	Acetyl esterase/lipase	312
649948299	100	28.57	23	92	5	74	7.0e-08	49	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649948301	1344	42.21	948	1343	84	480	4.0e-91	330	COG1530	Ribonuclease G or E	487
649948303	500	24.54	1	375	16	379	3.0e-37	150	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
649948304	314	32.95	1	313	19	365	5.0e-50	191	COG1060	2-iminoacetate synthase ThiH (tyrosine cleavage enzyme, thamine biosynthesis)	370
649948305	157	20.67	2	143	10	146	8.0e-06	43.4	COG4243	Uncharacterized membrane protein	156
649948306	303	24.76	1	303	16	298	7.0e-21	95	COG0863	DNA modification methylase	302
649948307	278	42.75	22	278	8	252	7.0e-56	210	COG0631	Serine/threonine protein phosphatase PrpC	262
649948308	155	41.83	1	151	10	159	1.0e-25	109	COG2030	Acyl dehydratase	159
649948310	346	26.28	1	319	4	251	5.0e-21	95.6	COG1235	Phosphoribosyl 1,2-cyclic phosphodiesterase	269
649948312	280	24.89	38	262	14	228	2.0e-16	80.2	COG0705	Membrane associated serine protease, rhomboid family	228
649948313	135	25.23	23	128	2	108	4.0e-07	46.9	COG1396	Transcriptional regulator, contains XRE-family HTH domain	120
649948314	148	22.41	1	115	1	110	3.0e-06	44.9	COG2315	Predicted DNA-binding protein with ?double-wing? structural motif, MmcQ/YjbR family	118
649948315	490	23.11	1	482	5	398	8.0e-46	178	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
649948323	395	76.71	1	395	1	394	0.0e+00	690	COG0050	Translation elongation factor EF-Tu, a GTPase	394
649948324	208	26.9	20	207	1	195	2.0e-19	89.6	COG4636	Endonuclease, Uma2 family (restriction endonuclease fold)	200
649948325	49	57.14	1	49	2	50	5.0e-08	49.4	COG0267	Ribosomal protein L33	50
649948328	226	44.32	50	224	3	178	3.0e-46	178	COG0250	Transcription antitermination factor NusG	178
649948329	144	65.71	3	142	1	138	1.0e-47	181	COG0080	Ribosomal protein L11	141
649948330	359	37.74	44	298	11	249	2.0e-48	186	COG1533	DNA repair photolyase	297
649948331	198	27.92	10	198	1	195	2.0e-18	85.7	COG4636	Endonuclease, Uma2 family (restriction endonuclease fold)	200
649948332	208	29.08	20	208	1	195	7.0e-21	93.8	COG4636	Endonuclease, Uma2 family (restriction endonuclease fold)	200
649948333	236	53.1	4	228	3	228	6.0e-72	264	COG0081	Ribosomal protein L1	228
649948334	245	33.71	1	174	1	175	6.0e-24	104	COG0244	Ribosomal protein L10	175
649948335	123	59.68	1	123	2	124	1.0e-21	95.3	COG0222	Ribosomal protein L7/L12	124
649948337	1396	48.96	19	853	7	807	0.0e+00	837	COG0086	DNA-directed RNA polymerase, beta' subunit/160 kD subunit	808
649948339	128	43.65	3	128	4	129	9.0e-25	105	COG3744	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain)	130
649948343	87	38.57	1	70	3	67	2.0e-09	53.9	COG4118	Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor	84
649948346	127	48.18	18	127	1	110	9.0e-31	125	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
649948347	399	35.44	1	394	1	393	5.0e-77	281	COG1459	Type II secretory pathway, component PulF	397
649948351	545	42.75	31	540	2	499	0.0e+00	503	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
649948357	317	21.01	9	121	3	121	9.0e-05	41.2	COG2165	Type II secretory pathway, pseudopilin PulG	149
649948358	416	40.83	5	408	3	355	6.0e-96	344	COG0484	DnaJ-class molecular chaperone with C-terminal Zn finger domain	371
649948359	127	52.94	23	107	6	90	1.0e-24	105	COG3093	Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain	104
649948360	92	50	1	92	1	94	2.0e-22	97.3	COG3549	Plasmid maintenance system killer protein	94
649948361	267	28.67	1	265	1	272	4.0e-42	165	COG0266	Formamidopyrimidine-DNA glycosylase	273
649948364	638	60.4	1	600	4	579	0.0e+00	664	COG0443	Molecular chaperone DnaK (HSP70)	579
649948369	338	31.91	35	291	6	248	3.0e-46	179	COG0300	Short-chain dehydrogenase	265
649948370	140	37.62	11	109	1	100	6.0e-13	66.7	COG0789	DNA-binding transcriptional regulator, MerR family	124
649948371	395	19.71	3	341	10	339	6.0e-21	95.4	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
649948374	520	33.05	1	471	2	451	5.0e-89	321	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	492
649948375	184	29.48	1	167	2	162	9.0e-18	83.4	COG2062	Phosphohistidine phosphatase SixA	163
649948378	211	18.46	34	205	46	232	4.0e-05	41.8	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
649948380	586	35.31	9	578	1	502	8.0e-108	384	COG1543	Predicted glycosyl hydrolase, contains GH57 and DUF1957 domains	504
649948382	128	24.58	5	118	3	113	7.0e-04	36.5	COG4980	Gas vesicle protein	115
649948384	379	43.94	10	378	5	352	1.0e-112	399	COG0482	tRNA U34 2-thiouridine synthase MnmA/TrmU, contains the PP-loop ATPase domain	356
649948386	115	31.37	7	107	5	104	8.0e-10	55.7	COG4679	Phage-related protein	116
649948387	368	26.4	38	360	17	362	3.0e-55	208	COG2021	Homoserine acetyltransferase	368
649948388	656	26.78	31	594	5	504	6.0e-57	215	COG3975	Predicted metalloprotease, contains C-terminal PDZ domain	558
649948389	183	49.16	1	179	2	160	1.0e-56	212	COG0386	Glutathione peroxidase, house-cleaning role in reducing lipid peroxides	162
649948390	626	20.39	33	474	17	458	3.0e-18	87.1	COG0531	Amino acid transporter	466
649948391	321	33.82	7	130	2	137	3.0e-10	59.8	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
649948392	218	30.41	25	214	20	207	7.0e-19	87.7	COG0400	Predicted esterase	207
649948393	344	25.29	12	340	3	334	1.0e-35	143	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
649948394	397	52.82	1	388	5	386	4.0e-125	441	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
649948398	370	26.48	4	347	3	345	1.0e-19	91.3	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
649948399	147	33.61	18	139	5	126	3.0e-11	61.1	COG1846	DNA-binding transcriptional regulator, MarR family	126
649948401	373	55.63	1	142	3	141	5.0e-46	178	COG0117	Pyrimidine deaminase domain of riboflavin biosynthesis protein RibD	146
649948402	220	38.5	1	209	1	203	3.0e-53	201	COG0307	Riboflavin synthase alpha chain	204
649948403	416	70.98	1	415	4	420	0.0e+00	684	COG1158	Transcription termination factor Rho	422
649948405	527	17.42	115	524	10	399	3.0e-25	110	COG3464	Transposase	402
649948410	187	42.35	1	179	2	197	2.0e-27	115	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649948411	680	26.82	156	411	15	267	3.0e-09	57.7	COG0457	Tetratricopeptide (TPR) repeat	291
649948417	288	20.96	1	227	2	221	3.0e-10	59.5	COG1475	Chromosome segregation protein Spo0J, contains ParB-like nuclease domain	240
649948418	513	25.29	11	184	2	163	3.0e-13	70.6	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
649948421	311	26.23	68	287	24	267	1.0e-09	57.2	COG1413	HEAT repeat	335
649948422	499	42.77	185	495	2	262	2.0e-77	283	COG1760	L-serine deaminase	262
649948424	392	46.17	1	392	1	391	1.0e-86	313	COG0183	Acetyl-CoA acetyltransferase	392
649948427	346	32.13	1	346	2	381	2.0e-36	146	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
649948428	377	50.53	8	377	18	390	8.0e-117	413	COG0372	Citrate synthase	390
649948431	181	33.33	1	171	11	176	1.0e-26	112	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649948433	338	46.85	13	338	9	340	4.0e-97	348	COG0552	Signal recognition particle GTPase	340
649948435	330	50.45	1	330	1	329	3.0e-106	378	COG0240	Glycerol-3-phosphate dehydrogenase	329
649948436	203	41.84	4	197	5	200	2.0e-40	159	COG0344	Phospholipid biosynthesis protein PlsY, probable glycerol-3-phosphate acyltransferase	200
649948437	422	37.7	1	249	2	249	2.0e-50	193	COG1058	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	255
649948440	165	38.13	19	156	22	155	5.0e-17	80.7	COG1267	Phosphatidylglycerophosphatase A	160
649948441	75	40	1	53	2	56	2.0e-08	50.8	COG3024	Endogenous inhibitor of DNA gyrase, YacG/DUF329 family	65
649948442	581	37.28	245	581	113	437	3.0e-87	316	COG0621	tRNA A37 methylthiotransferase MiaB	437
649948444	289	30.34	34	259	21	243	1.0e-21	97	COG4242	Cyanophycinase and related exopeptidases	293
649948445	435	28.73	1	435	1	381	3.0e-39	156	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649948447	320	33.71	6	320	2	322	2.0e-59	222	COG0142	Geranylgeranyl pyrophosphate synthase	322
649948450	424	37.82	67	415	27	353	2.0e-75	276	COG4225	Rhamnogalacturonyl hydrolase YesR	357
649948454	355	33.53	8	336	7	317	2.0e-69	256	COG1899	Deoxyhypusine synthase	318
649948456	64	53.97	1	63	2	64	3.0e-18	83.3	COG1476	DNA-binding transcriptional regulator, XRE-family HTH domain	68
649948458	443	30.18	10	434	1	377	4.0e-63	235	COG1488	Nicotinic acid phosphoribosyltransferase	405
649948461	255	28.42	8	176	1	182	1.0e-17	83.4	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
649948462	219	44.66	13	208	5	209	7.0e-51	193	COG0572	Uridine kinase	218
649948463	282	40.58	10	282	1	262	7.0e-62	230	COG0005	Purine nucleoside phosphorylase	262
649948464	212	25.58	1	210	2	204	3.0e-21	95	COG0778	Nitroreductase	207
649948468	254	43.95	1	245	1	245	5.0e-61	227	COG3967	Short-chain dehydrogenase involved in D-alanine esterification of teichoic acids	245
649948469	640	20.73	254	521	5	261	2.0e-07	51.6	COG4257	Streptogramin lyase	353
649948470	412	42.48	1	411	1	403	7.0e-101	360	COG1972	Nucleoside permease NupC	404
649948472	250	38.25	5	248	4	251	1.0e-33	136	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948474	451	47.31	4	449	4	434	7.0e-123	434	COG0213	Thymidine phosphorylase	435
649948475	140	50.78	13	139	7	132	1.0e-31	128	COG0295	Cytidine deaminase	134
649948477	165	31.69	2	143	14	151	5.0e-16	77.3	COG0835	Chemotaxis signal transduction protein	165
649948480	275	37.69	5	270	1	265	1.0e-57	216	COG1352	Methylase of chemotaxis methyl-accepting proteins	268
649948481	1609	32.8	38	967	4	799	0.0e+00	669	COG1201	Lhr-like helicase	814
649948482	305	41.75	1	305	1	306	1.0e-67	250	COG3781	Predicted membrane chloride channel, bestrophin family	306
649948483	426	31.98	34	420	2	350	3.0e-49	189	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
649948484	234	30.05	56	233	1	203	2.0e-23	102	COG1335	Nicotinamidase-related amidase	205
649948486	419	19.42	60	403	59	390	7.0e-07	48.7	COG2814	Predicted arabinose efflux permease, MFS family	394
649948487	149	24.56	23	136	6	119	1.0e-09	56.1	COG1846	DNA-binding transcriptional regulator, MarR family	126
649948488	210	23.62	11	206	1	199	5.0e-10	58.1	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649948489	292	30.57	11	291	4	310	1.0e-52	199	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
649948490	204	51.28	3	154	1	155	2.0e-48	185	COG0245	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	159
649948491	244	40.08	1	237	3	230	2.0e-57	215	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	230
649948493	936	28.04	69	931	1	765	2.0e-89	324	COG2366	Acyl-homoserine lactone (AHL) acylase PvdQ	768
649948496	177	24.72	3	176	1	163	1.0e-16	79.6	COG0262	Dihydrofolate reductase	167
649948499	401	52.71	16	400	1	382	0.0e+00	469	COG0743	1-deoxy-D-xylulose 5-phosphate reductoisomerase	385
649948501	281	37.45	2	273	4	263	2.0e-28	120	COG0575	CDP-diglyceride synthetase	265
649948502	346	38.41	24	335	1	305	6.0e-74	271	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
649948503	301	50	19	272	7	245	7.0e-74	270	COG0020	Undecaprenyl pyrophosphate synthase	245
649948504	177	31.25	64	158	1	96	7.0e-08	50.4	COG1396	Transcriptional regulator, contains XRE-family HTH domain	120
649948505	204	43.59	6	199	30	212	4.0e-38	151	COG2316	Predicted hydrolase, HD superfamily	212
649948507	208	29.95	3	191	1	180	1.0e-27	116	COG1335	Nicotinamidase-related amidase	205
649948509	520	31.94	27	518	23	486	5.0e-82	298	COG1621	Sucrose-6-phosphate hydrolase SacC, GH32 family	486
649948510	581	39.78	18	573	5	516	0.0e+00	490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component	526
649948512	283	40.47	1	256	4	257	6.0e-48	184	COG1024	Enoyl-CoA hydratase/carnithine racemase	257
649948513	494	37.14	12	483	11	470	1.0e-115	410	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	472
649948515	227	31.93	81	197	7	123	2.0e-13	69.9	COG0526	Thiol-disulfide isomerase or thioredoxin	127
649948516	324	51.26	11	208	10	202	9.0e-46	177	COG0794	D-arabinose 5-phosphate isomerase GutQ	202
649948518	266	39.34	3	182	7	189	2.0e-42	166	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
649948520	345	34.8	37	283	22	261	4.0e-38	152	COG3481	3'-5' exoribonuclease YhaM, can participate in 23S rRNA maturation,  HD superfamily	287
649948521	672	21	94	362	39	312	3.0e-11	64	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
649948522	557	37.74	26	383	4	357	2.0e-80	293	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	406
649948524	191	22.22	2	190	8	196	7.0e-09	53.9	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649948530	2221	21.55	10	444	27	467	2.0e-24	109	COG5434	Polygalacturonase	542
649948533	325	53.07	4	323	1	322	2.0e-105	376	COG0158	Fructose-1,6-bisphosphatase	326
649948534	307	30.53	1	279	1	273	2.0e-48	186	COG0266	Formamidopyrimidine-DNA glycosylase	273
649948535	830	37.42	157	744	67	632	5.0e-127	449	COG0744	Membrane carboxypeptidase (penicillin-binding protein)	661
649948537	236	25.71	9	211	4	213	6.0e-21	94.5	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649948538	398	44.13	1	391	8	368	7.0e-106	377	COG0082	Chorismate synthase	369
649948539	188	52.15	24	184	6	168	2.0e-50	191	COG0242	Peptide deformylase	168
649948540	313	49.04	1	309	2	307	7.0e-92	330	COG0223	Methionyl-tRNA formyltransferase	307
649948541	459	32.22	144	458	1	354	8.0e-48	185	COG0144	16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family	355
649948544	383	20.45	77	319	85	335	9.0e-12	64.9	COG2706	6-phosphogluconolactonase, cycloisomerase 2 family	346
649948545	111	54.17	2	97	1	96	4.0e-27	113	COG3093	Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain	104
649948546	97	49.47	1	94	1	94	2.0e-23	100	COG3549	Plasmid maintenance system killer protein	94
649948548	511	45.22	2	511	6	516	0.0e+00	518	COG0029	Aspartate oxidase	518
649948549	505	21.69	155	495	77	400	4.0e-13	70	COG2234	Zn-dependent amino- or carboxypeptidase, M28 family	435
649948550	383	45.48	13	373	1	359	9.0e-104	370	COG0337	3-dehydroquinate synthetase	360
649948551	261	34.62	29	256	12	238	3.0e-54	205	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
649948552	484	33.66	12	319	6	299	1.0e-54	207	COG0053	Divalent metal cation (Fe/Co/Zn/Cd) transporter	304
649948553	395	37.37	7	393	9	370	7.0e-85	307	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
649948554	102	48.68	4	79	2	77	1.0e-21	94.6	COG1923	sRNA-binding regulator protein Hfq	77
649948555	155	23.36	16	152	10	146	3.0e-05	41.4	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	161
649948556	238	28.57	73	231	1	161	1.0e-09	56.8	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	161
649948557	182	32.22	1	180	1	178	3.0e-26	111	COG0712	FoF1-type ATP synthase, delta subunit	178
649948558	515	69.38	3	505	2	504	0.0e+00	800	COG0056	FoF1-type ATP synthase, alpha subunit	504
649948559	363	39	6	363	2	286	5.0e-69	255	COG0224	FoF1-type ATP synthase, gamma subunit	287
649948560	479	70.08	4	478	2	467	0.0e+00	775	COG0055	FoF1-type ATP synthase, beta subunit	468
649948561	143	34.62	10	138	4	125	8.0e-18	83	COG0355	FoF1-type ATP synthase, epsilon subunit	135
649948562	354	44.17	6	354	4	359	7.0e-87	314	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
649948563	218	25.53	1	187	3	190	8.0e-10	57.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649948565	794	23.02	116	790	44	768	1.0e-32	135	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
649948568	242	60.49	1	241	2	243	4.0e-99	354	COG1137	ABC-type lipopolysaccharide export system, ATPase component	243
649948569	570	32.1	3	568	1	441	2.0e-89	323	COG1508	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog	444
649948570	121	23.21	1	110	1	109	4.0e-09	53.7	COG1544	Ribosome-associated translation inhibitor RaiA	110
649948572	848	35.6	8	632	7	546	0.0e+00	495	COG0143	Methionyl-tRNA synthetase	558
649948573	285	38.81	45	258	11	229	1.0e-40	160	COG2186	DNA-binding transcriptional regulator, FadR family	241
649948574	467	20.65	26	409	27	398	1.0e-14	74.5	COG2271	Sugar phosphate permease	448
649948575	332	31.31	26	322	84	404	3.0e-43	169	COG4677	Pectin methylesterase and related acyl-CoA thioesterases	405
649948577	209	29.82	1	204	1	218	9.0e-19	87.1	COG1214	tRNA A37 threonylcarbamoyladenosine modification protein TsaB	220
649948578	164	30.67	9	144	23	172	7.0e-12	63.5	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
649948580	243	30.91	15	225	17	234	2.0e-36	145	COG0688	Phosphatidylserine decarboxylase	239
649948581	286	31.94	19	279	1	234	9.0e-40	157	COG1183	Phosphatidylserine synthase	234
649948582	347	25.15	6	337	2	333	6.0e-25	108	COG0136	Aspartate-semialdehyde dehydrogenase	334
649948583	256	40.08	4	253	3	249	2.0e-39	156	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948584	376	39.79	8	376	5	363	1.0e-93	337	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
649948585	302	41.06	16	273	2	255	2.0e-56	212	COG2514	Catechol-2,3-dioxygenase	265
649948587	221	22.82	15	220	4	201	8.0e-11	60.8	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649948589	1178	28.07	744	1167	8	426	2.0e-47	185	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
649948590	542	41.58	48	527	1	470	6.0e-117	415	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
649948591	218	22.97	3	203	2	210	4.0e-22	98.1	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649948592	550	33.73	225	550	1	303	4.0e-54	206	COG0492	Thioredoxin reductase	305
649948594	142	59.12	6	142	4	138	2.0e-47	181	COG3565	Predicted dioxygenase of extradiol dioxygenase family	138
649948597	217	20.27	1	211	5	200	3.0e-03	35.4	COG2834	Outer membrane lipoprotein-sorting protein	211
649948599	451	57.34	4	443	1	426	0.0e+00	565	COG0172	Seryl-tRNA synthetase	429
649948600	317	39.54	16	313	1	305	7.0e-63	234	COG0167	Dihydroorotate dehydrogenase	310
649948602	765	52.87	15	747	14	757	0.0e+00	817	COG2183	Transcriptional accessory protein Tex/SPT6	780
649948603	543	58.08	20	542	1	515	0.0e+00	671	COG0138	AICAR transformylase/IMP cyclohydrolase PurH	515
649948605	383	35.82	19	372	20	406	1.0e-69	257	COG0232	dGTP triphosphohydrolase	412
649948609	527	36.08	5	497	14	514	3.0e-115	409	COG1640	4-alpha-glucanotransferase	520
649948612	346	38.86	15	345	3	333	2.0e-82	299	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
649948613	477	31.16	33	455	3	467	8.0e-54	204	COG3119	Arylsulfatase A or related enzyme	475
649948620	386	28.32	12	346	1	342	2.0e-48	186	COG0673	Predicted dehydrogenase	342
649948621	253	39.63	13	225	2	217	1.0e-41	163	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
649948622	341	22.63	19	273	19	276	2.0e-14	73.9	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
649948624	527	30.44	1	503	2	529	6.0e-93	335	COG1069	Ribulose kinase	544
649948625	483	57.14	6	483	7	487	0.0e+00	628	COG2160	L-arabinose isomerase	497
649948626	233	36.05	1	233	3	219	5.0e-50	190	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
649948627	199	40.64	13	196	2	188	2.0e-37	149	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
649948628	68	47.83	1	68	1	69	6.0e-08	49.2	COG3585	Molybdopterin-binding protein	69
649948631	141	45.59	71	137	2	69	2.0e-10	58	COG3585	Molybdopterin-binding protein	69
649948632	690	32.29	34	689	14	672	9.0e-99	355	COG1874	Beta-galactosidase GanA	673
649948633	297	38.25	48	294	1	250	3.0e-53	202	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948635	528	44.76	132	416	65	345	3.0e-59	223	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
649948636	430	25.44	34	297	42	325	5.0e-15	76.2	COG4219	Signal transducer regulating beta-lactamase production, contains  metallopeptidase domain	337
649948637	137	26.09	8	122	3	117	5.0e-12	63.7	COG3682	Predicted transcriptional regulator	123
649948638	419	27.21	19	419	1	419	6.0e-31	128	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649948639	412	27.36	17	412	1	419	4.0e-26	112	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649948642	248	38.84	8	248	1	229	3.0e-50	192	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649948644	225	26.13	1	222	1	203	2.0e-19	89.5	COG2095	Small neutral amino acid transporter SnatA, MarC family	203
649948646	546	34.25	37	533	4	482	4.0e-83	302	COG2272	Carboxylesterase type B	491
649948648	441	26.98	77	438	3	349	2.0e-21	97.6	COG3391	DNA-binding beta-propeller fold protein YncE	381
649948651	224	28.97	11	221	8	220	7.0e-25	107	COG2386	ABC-type transport system involved in cytochrome c biogenesis, permease component	221
649948652	159	44.08	6	157	1	152	4.0e-34	137	COG2606	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC	155
649948653	399	35.68	161	382	6	225	1.0e-49	190	COG1131	ABC-type multidrug transport system, ATPase component	293
649948656	174	32.58	2	174	67	243	9.0e-24	103	COG1651	Protein-disulfide isomerase	244
649948657	523	64.87	73	496	2	427	0.0e+00	681	COG0422	Thiamine biosynthesis protein ThiC	432
649948660	147	45.67	1	127	3	113	4.0e-24	104	COG1970	Large-conductance mechanosensitive channel	130
649948663	347	50.9	15	347	17	346	4.0e-109	388	COG0182	Methylthioribose-1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit	346
649948667	219	34.31	9	212	7	175	2.0e-32	132	COG0461	Orotate phosphoribosyltransferase	201
649948671	387	30.16	88	384	80	381	5.0e-34	138	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649948676	266	37.08	74	251	4	177	2.0e-30	125	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649948680	517	24.56	25	477	4	416	1.0e-58	220	COG1239	Mg-chelatase subunit ChlI	423
649948681	158	26.19	1	158	1	162	3.0e-19	88	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
649948683	173	48.25	12	154	11	153	5.0e-38	150	COG1607	Acyl-CoA hydrolase	157
649948684	276	40.27	11	232	50	265	2.0e-47	182	COG0489	Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster	265
649948685	362	33.24	6	356	1	338	5.0e-59	221	COG1420	Transcriptional regulator of heat shock response	346
649948686	181	35.39	3	176	19	193	9.0e-27	113	COG0576	Molecular chaperone GrpE (heat shock protein)	193
649948687	383	52.63	6	383	1	370	5.0e-127	447	COG0484	DnaJ-class molecular chaperone with C-terminal Zn finger domain	371
649948688	255	37.08	18	254	16	244	4.0e-42	165	COG1385	16S rRNA U1498 N3-methylase RsmE	246
649948691	360	28.48	34	355	16	340	3.0e-28	119	COG0628	Predicted PurR-regulated permease PerM	355
649948692	194	37.57	21	190	3	166	1.0e-34	139	COG0703	Shikimate kinase	172
649948694	250	33.89	1	238	17	241	1.0e-36	147	COG5429	Uncharacterized protein	261
649948695	604	39.44	2	507	1	529	1.0e-119	424	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
649948697	432	29.88	33	432	12	402	2.0e-44	174	COG1228	Imidazolonepropionase or related amidohydrolase	406
649948698	166	20.83	18	158	18	157	2.0e-05	41.9	COG2318	Uncharacterized damage-inducible protein DinB (forms a four-helix bundle)	172
649948699	258	59.62	1	258	1	255	7.0e-97	347	COG0623	Enoyl-[acyl-carrier-protein] reductase (NADH)	259
649948700	125	28.78	3	120	5	143	1.0e-15	75.4	COG2947	Predicted RNA-binding protein, contains PUA-like domain	156
649948701	271	42.59	9	271	6	269	7.0e-64	237	COG0796	Glutamate racemase	269
649948703	339	23.79	4	260	1	227	7.0e-16	78.5	COG0860	N-acetylmuramoyl-L-alanine amidase	231
649948704	464	24.36	2	463	1	404	2.0e-43	170	COG4198	Uncharacterized conserved protein, DUF1015 family	405
649948710	778	33.71	10	777	48	832	0.0e+00	479	COG1643	HrpA-like RNA helicase	845
649948711	251	30.24	8	211	5	193	5.0e-31	128	COG0300	Short-chain dehydrogenase	265
649948713	325	25.17	1	297	2	291	1.0e-21	97.9	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649948715	180	19.75	3	163	1	127	7.0e-05	40.6	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	153
649948716	366	56.18	1	366	1	372	0.0e+00	474	COG0012	Ribosome-binding ATPase YchF, GTP1/OBG family	372
649948717	455	26.13	2	323	30	337	1.0e-49	191	COG3673	Uncharacterized protein, PA2063/DUF2235 family	423
649948718	322	42.68	1	322	1	326	1.0e-77	283	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
649948725	192	21.76	1	191	1	193	1.0e-09	56.6	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649948726	307	26.25	7	236	2	209	4.0e-14	72.6	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948727	326	27.86	19	276	2	242	1.0e-21	97.2	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948728	196	21.74	12	171	1	161	7.0e-06	43.9	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649948729	557	47.86	1	545	2	524	0.0e+00	483	COG0459	Chaperonin GroEL (HSP60 family)	524
649948730	99	60	5	99	2	96	7.0e-31	125	COG0234	Co-chaperonin GroES (HSP10)	96
649948732	252	40	15	250	3	250	2.0e-40	159	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948733	266	35.95	1	241	1	240	3.0e-48	185	COG4464	Tyrosine-protein phosphatase YwqE	254
649948734	232	50.87	1	229	3	231	2.0e-84	305	COG0047	Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain	231
649948736	66	55.22	1	66	1	67	7.0e-21	92.1	COG1278	Cold shock protein, CspA family	67
649948737	209	44.08	7	209	1	211	6.0e-48	184	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649948739	590	32.02	61	588	1	523	3.0e-93	336	COG4986	ABC-type anion transport system, duplicated permease component	523
649948740	448	42.35	4	258	2	248	2.0e-75	276	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
649948742	196	24.86	22	193	3	179	4.0e-20	91.5	COG0110	Acetyltransferase (isoleucine patch superfamily)	190
649948743	394	21.13	8	390	1	380	3.0e-25	110	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649948744	431	26.81	56	417	25	381	1.0e-27	118	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649948745	342	27.75	49	249	25	228	1.0e-15	77.5	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
649948746	753	23.78	31	472	14	458	1.0e-41	165	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
649948747	471	48.74	5	440	1	413	0.0e+00	492	COG1004	UDP-glucose 6-dehydrogenase	414
649948748	320	34.82	6	309	3	310	2.0e-48	185	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649948750	243	24.39	16	230	29	312	2.0e-13	69.9	COG1071	TPP-dependent pyruvate or acetoin dehydrogenase subunit alpha	358
649948751	893	54.99	16	893	13	887	0.0e+00	1135	COG2609	Pyruvate dehydrogenase complex, dehydrogenase (E1) component	887
649948752	412	44.61	8	412	10	404	7.0e-110	391	COG1364	N-acetylglutamate synthase (N-acetylornithine aminotransferase)	404
649948753	357	31.34	1	357	1	342	3.0e-49	189	COG0673	Predicted dehydrogenase	342
649948754	513	23.72	98	500	42	443	3.0e-33	136	COG1538	Outer membrane protein TolC	457
649948755	454	32.33	40	436	9	345	4.0e-55	209	COG1566	Multidrug resistance efflux pump	352
649948757	198	34.67	40	189	8	155	1.0e-27	116	COG0783	DNA-binding ferritin-like protein (oxidative damage protectant)	156
649948758	199	43.37	4	199	2	189	7.0e-54	203	COG0163	3-polyprenyl-4-hydroxybenzoate decarboxylase	191
649948760	432	46.58	1	431	1	438	0.0e+00	488	COG0015	Adenylosuccinate lyase	438
649948761	85	26.56	1	62	1	64	1.0e-09	54.6	COG0695	Glutaredoxin	80
649948762	258	48.62	4	251	2	250	8.0e-57	213	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948763	292	61.22	1	146	5	151	3.0e-50	192	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
649948765	360	38.81	10	360	15	345	5.0e-89	321	COG2957	Agmatine/peptidylarginine deiminase	346
649948770	527	17.42	115	524	10	399	3.0e-25	110	COG3464	Transposase	402
649948772	228	31.25	42	217	23	184	2.0e-15	76.6	COG3544	Uncharacterized conserved protein, DUF305 family	190
649948773	153	26.92	21	150	3	126	5.0e-06	44.2	COG1846	DNA-binding transcriptional regulator, MarR family	126
649948775	309	33.78	7	300	4	267	9.0e-54	204	COG0388	Predicted amidohydrolase	274
649948776	476	32.89	37	467	2	443	5.0e-76	278	COG0174	Glutamine synthetase	443
649948777	309	48.38	3	306	1	307	6.0e-100	357	COG0039	Malate/lactate dehydrogenase	313
649948778	173	46.75	8	170	1	157	1.0e-48	185	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
649948779	262	42.29	66	233	1	158	4.0e-36	144	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
649948780	98	24.24	1	97	1	99	2.0e-06	44.2	COG1359	Quinol monooxygenase YgiN	100
649948781	376	33.9	13	366	3	307	2.0e-65	243	COG2355	Zn-dependent dipeptidase, microsomal dipeptidase homolog	313
649948783	135	42.96	1	135	4	138	6.0e-25	106	COG3193	Uncharacterized conserved protein GlcG, DUF336 family	141
649948784	331	21.01	38	308	1	241	6.0e-11	61.9	COG1409	3',5'-cyclic AMP phosphodiesterase CpdA	301
649948787	251	33.33	6	247	1	234	2.0e-53	202	COG0479	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit	234
649948789	589	40.28	7	576	9	561	0.0e+00	494	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	562
649948790	268	19.3	29	137	17	129	6.0e-05	41.8	COG2009	Succinate dehydrogenase/fumarate reductase, cytochrome b subunit	132
649948791	210	36.89	4	209	3	191	5.0e-42	164	COG0127	Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family	194
649948795	255	34	1	244	2	242	6.0e-43	167	COG1360	Flagellar motor protein MotB	244
649948796	261	39.44	1	250	1	251	5.0e-56	211	COG1291	Flagellar motor component MotA	266
649948797	92	44.83	1	58	1	58	3.0e-14	69.9	COG1582	Uncharacterized protein YlzI, FlbEa/FlbD family	67
649948798	408	29.21	5	408	3	360	3.0e-26	113	COG1344	Flagellin and related hook-associated protein FlgL	360
649948799	458	24.58	7	441	5	471	2.0e-23	104	COG1345	Flagellar capping protein FliD	483
649948800	155	33.33	6	113	10	117	8.0e-14	69.9	COG1516	Flagellin-specific chaperone FliS	132
649948801	582	38.53	5	575	4	567	3.0e-128	452	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
649948802	230	40.74	6	166	44	203	3.0e-30	125	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	205
649948803	530	44.15	1	529	1	475	0.0e+00	515	COG0043	3-polyprenyl-4-hydroxybenzoate decarboxylase	477
649948806	136	27.78	1	121	2	119	2.0e-06	45.2	COG1487	Predicted nucleic acid-binding protein, contains PIN domain	133
649948807	178	24.81	37	162	20	134	7.0e-05	40.7	COG3915	Uncharacterized protein	155
649948808	166	39.19	8	155	15	147	5.0e-33	133	COG1143	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)	172
649948809	202	22.63	24	196	38	218	6.0e-07	47.8	COG1418	HD superfamily phosphodieaserase, includes HD domain of RNase Y	222
649948810	365	48.55	9	353	8	311	2.0e-90	326	COG0646	Methionine synthase I (cobalamin-dependent), methyltransferase domain	311
649948811	902	57.29	7	866	10	842	0.0e+00	1070	COG1410	Methionine synthase I, cobalamin-binding domain	842
649948814	428	35.21	8	412	4	401	4.0e-84	305	COG0498	Threonine synthase	411
649948815	93	23.33	2	91	1	84	1.0e-05	41.5	COG1977	Molybdopterin converting factor, small subunit	84
649948817	807	58.57	7	784	1	782	0.0e+00	1075	COG0466	ATP-dependent Lon protease, bacterial type	782
649948818	428	61.59	14	427	1	401	0.0e+00	604	COG1219	ATP-dependent protease Clp, ATPase subunit	408
649948819	197	65.98	1	194	1	193	5.0e-74	270	COG0740	ATP-dependent protease ClpP, protease subunit	200
649948820	478	32.1	48	478	8	425	2.0e-60	227	COG0544	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)	441
649948822	291	30.04	68	288	10	198	2.0e-27	116	COG1573	Uracil-DNA glycosylase	202
649948824	98	31.71	1	82	2	83	8.0e-07	45.3	COG4980	Gas vesicle protein	115
649948826	821	50.25	4	786	1	766	0.0e+00	866	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
649948827	226	42.79	5	225	2	220	2.0e-66	245	COG1136	ABC-type lipoprotein export system, ATPase component	226
649948828	162	32.58	16	145	44	175	1.0e-18	86	COG2128	Alkylhydroperoxidase family enzyme, contains CxxC motif	177
649948829	415	40	1	415	3	408	2.0e-88	319	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
649948830	335	38.69	1	333	1	335	2.0e-93	336	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
649948833	121	42.62	35	95	10	70	1.0e-11	61.9	COG3311	Predicted DNA-binding transcriptional regulator AlpA	70
649948836	343	27.52	6	328	3	303	7.0e-29	121	COG3547	Transposase	303
649948837	317	33.23	11	316	2	312	2.0e-37	149	COG0657	Acetyl esterase/lipase	312
649948838	335	39.71	1	334	1	326	4.0e-63	235	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
649948845	198	39.15	1	181	2	189	1.0e-33	136	COG2085	Predicted dinucleotide-binding enzyme	211
649948846	298	23.87	59	279	78	267	1.0e-18	87.4	COG0726	Peptidoglycan/xylan/chitin deacetylase, PgdA/CDA1 family	267
649948847	167	21.9	26	160	16	149	6.0e-05	40.8	COG3832	Uncharacterized conserved protein YndB, AHSA1/START domain	149
649948848	252	32.99	12	102	15	110	9.0e-09	54.2	COG4922	Predicted SnoaL-like aldol condensation-catalyzing enzyme	129
649948849	200	17.8	7	195	5	189	8.0e-09	53.9	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649948850	249	38.1	4	246	3	250	5.0e-42	164	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948851	260	43.03	3	244	2	250	2.0e-48	185	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649948852	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649948853	314	28.41	14	281	10	274	2.0e-23	103	COG0583	DNA-binding transcriptional regulator, LysR family	297
649948855	202	25.77	22	181	10	154	2.0e-07	49.2	COG5654	Uncharacterized conserved protein, contains RES domain	163
649948857	60	39.29	5	60	2	57	2.0e-03	34.1	COG3847	Flp pilus assembly protein, pilin Flp	58
649948862	394	26.9	14	393	2	381	8.0e-36	144	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649948863	309	32	1	247	1	218	9.0e-35	140	COG3394	Predicted glycoside hydrolase or deacetylase ChbG, UPF0249 family	257
649948864	141	27.48	3	125	1	131	1.0e-04	39	COG1848	Predicted nucleic acid-binding protein, contains PIN domain	140
649948866	439	23.88	48	431	14	397	7.0e-28	118	COG4320	Uncharacterized conserved protein, DUF2252 family	410
649948867	662	64.71	1	662	3	663	0.0e+00	1027	COG0556	Excinuclease UvrABC helicase subunit UvrB	663
649948868	194	30.65	1	191	1	198	8.0e-31	126	COG0406	Broad specificity phosphatase PhoE	208
649948869	360	19.77	23	339	53	370	8.0e-11	61.7	COG2730	Aryl-phospho-beta-D-glucosidase BglC, GH1 family	407
649948870	242	28.87	5	240	3	217	1.0e-31	129	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
649948873	167	22.45	35	167	10	154	3.0e-09	54.9	COG1225	Peroxiredoxin	157
649948874	201	41.67	1	201	2	201	1.0e-44	173	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	201
649948875	263	42.79	1	224	1	225	9.0e-55	207	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649948880	174	39.13	11	166	5	157	8.0e-28	116	COG0597	Lipoprotein signal peptidase	167
649948881	1000	44.41	10	979	3	930	0.0e+00	1052	COG0060	Isoleucyl-tRNA synthetase	933
649948882	307	19.66	74	306	20	243	5.0e-05	42.1	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
649948883	549	37.04	197	547	62	408	9.0e-46	178	COG0840	Methyl-accepting chemotaxis protein	408
649948884	208	25.27	15	184	3	176	2.0e-13	69.1	COG1437	Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function)	178
649948885	349	48.74	19	216	13	209	3.0e-57	215	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
649948887	211	33.51	21	204	27	214	4.0e-25	108	COG3201	Nicotinamide riboside transporter PnuC	222
649948888	466	28.17	7	465	4	410	1.0e-53	204	COG2124	Cytochrome P450	411
649948889	220	42.66	3	220	2	206	4.0e-48	184	COG0125	Thymidylate kinase	208
649948891	335	43.58	1	332	4	332	3.0e-79	289	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	338
649948893	152	45.45	25	142	1	118	5.0e-24	103	COG4994	Uncharacterized protein	120
649948894	654	29.9	19	317	10	301	6.0e-28	119	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
649948895	200	26.77	1	192	1	184	6.0e-19	87.4	COG0431	NAD(P)H-dependent FMN reductase	184
649948897	256	25.51	61	256	32	207	1.0e-22	99	COG1845	Heme/copper-type cytochrome/quinol oxidase, subunit 3	209
649948898	559	45.21	3	523	11	504	3.0e-123	436	COG0843	Heme/copper-type cytochrome/quinol oxidase, subunit 1	566
649948899	240	24.89	7	237	20	226	6.0e-32	130	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	247
649948901	207	50	11	199	1	194	9.0e-54	203	COG0311	Glutamine amidotransferase PdxT (pyridoxal biosynthesis)	194
649948902	173	27.33	4	162	15	166	7.0e-11	60.4	COG3184	Uncharacterized protein	183
649948903	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649948904	584	22.88	9	559	15	517	1.0e-30	128	COG0433	Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase domains	520
649948907	316	65.81	7	316	8	296	4.0e-117	414	COG0214	Pyridoxal biosynthesis lyase PdxS	296
649948909	418	26.01	12	299	4	292	1.0e-37	151	COG0389	Nucleotidyltransferase/DNA polymerase involved in DNA repair	354
649948910	154	29	46	141	36	134	2.0e-07	48.5	COG2050	Acyl-coenzyme A thioesterase PaaI, contains HGG motif	141
649948912	749	34.51	22	749	12	727	0.0e+00	505	COG1529	CO or xanthine dehydrogenase, Mo-binding subunit	731
649948913	337	34.8	1	336	1	284	4.0e-60	225	COG1319	CO or xanthine dehydrogenase, FAD-binding subunit	284
649948914	241	60.23	68	237	1	154	1.0e-56	213	COG2080	Aerobic-type carbon monoxide dehydrogenase, small subunit, CoxS/CutS family	156
649948915	526	27.65	46	523	40	493	1.0e-67	251	COG2939	Carboxypeptidase C (cathepsin A)	498
649948917	388	65.35	8	209	3	203	3.0e-78	285	COG0108	3,4-dihydroxy-2-butanone 4-phosphate synthase	203
649948919	221	22.86	9	208	2	211	5.0e-16	78	COG1011	FMN phosphatase YigB, HAD superfamily	229
649948920	387	26.13	4	383	2	391	4.0e-45	175	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
649948921	209	34.11	1	206	12	225	1.0e-28	119	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
649948922	102	43.21	4	84	1	80	3.0e-10	56.8	COG1314	Preprotein translocase subunit SecG	86
649948923	322	30	189	298	18	127	3.0e-16	79.5	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
649948925	698	19.96	39	562	14	545	2.0e-14	75.1	COG1289	Uncharacterized membrane protein YccC	674
649948926	412	27.64	16	412	5	337	2.0e-50	193	COG1566	Multidrug resistance efflux pump	352
649948928	514	29.67	84	501	44	450	6.0e-44	172	COG1538	Outer membrane protein TolC	457
649948931	427	21.05	75	412	61	388	4.0e-11	62.9	COG2814	Predicted arabinose efflux permease, MFS family	394
649948933	235	18.34	10	233	6	224	1.0e-16	80.3	COG1011	FMN phosphatase YigB, HAD superfamily	229
649948934	1102	27.58	12	379	2	377	2.0e-42	168	COG0515	Serine/threonine protein kinase	384
649948935	562	42.57	147	442	62	342	3.0e-56	213	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
649948937	584	38.84	8	569	3	535	4.0e-120	425	COG1574	Predicted amidohydrolase YtcJ	535
649948941	179	25.18	1	136	1	136	1.0e-08	53.3	COG1943	REP element-mobilizing transposase RayT	136
649948943	465	51.84	1	463	1	451	0.0e+00	543	COG0541	Signal recognition particle GTPase	451
649948944	311	45.42	15	303	15	300	2.0e-76	279	COG4974	Site-specific recombinase XerD	300
649948945	310	38.83	1	309	2	300	4.0e-78	284	COG4974	Site-specific recombinase XerD	300
649948947	657	32.28	370	646	61	335	1.0e-35	144	COG0642	Signal transduction histidine kinase	336
649948948	467	47.29	1	461	3	454	0.0e+00	479	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
649948949	130	37.27	23	130	6	110	1.0e-15	75.7	COG0607	Rhodanese-related sulfurtransferase	110
649948950	689	51.61	5	684	2	676	0.0e+00	819	COG1770	Protease II	682
649948951	224	28.37	72	209	29	168	1.0e-10	60.5	COG3652	Predicted outer membrane protein	170
649948952	257	31.7	6	254	6	268	7.0e-33	134	COG1512	Uncharacterized membrane protein YgcG, contains a TPM-fold domain	271
649948953	193	36.98	1	189	1	185	3.0e-41	161	COG1704	Uncharacterized conserved protein	185
649948955	420	28.06	5	414	7	412	8.0e-56	211	COG1914	Mn2+ and Fe2+ transporters of the NRAMP family	416
649948956	159	29.14	13	158	2	141	3.0e-10	58.1	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
649948957	236	25.12	23	231	8	206	2.0e-15	75.7	COG0560	Phosphoserine phosphatase	212
649948958	171	31.43	10	149	1	140	9.0e-30	123	COG3871	General stress protein 26 (function unknown)	145
649948959	220	24.27	14	216	8	210	2.0e-18	86.6	COG2834	Outer membrane lipoprotein-sorting protein	211
649948961	436	37.62	17	428	16	435	1.0e-94	340	COG0612	Predicted Zn-dependent peptidase	438
649948962	383	43.02	22	376	4	346	7.0e-95	341	COG0820	Adenine C2-methylase RlmN of 23S rRNA A2503 and tRNA A37	349
649948964	342	39.3	8	339	7	323	3.0e-71	262	COG0391	Archaeal 2-phospho-L-lactate transferase/Bacterial gluconeogenesis factor, CofD/UPF0052 family	323
649948966	444	33.01	33	435	8	409	7.0e-62	231	COG4102	Uncharacterized conserved protein, DUF1501 family	418
649948967	141	33.1	2	139	5	138	2.0e-09	55	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
649948969	103	39.05	1	103	2	106	2.0e-15	73.8	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	106
649948971	380	55.91	1	380	2	367	0.0e+00	540	COG0505	Carbamoylphosphate synthase small subunit	368
649948972	213	24.8	12	134	11	132	2.0e-08	52.6	COG1943	REP element-mobilizing transposase RayT	136
649948973	1099	67.16	13	414	1	390	0.0e+00	546	COG0458	Carbamoylphosphate synthase large subunit	400
649948978	341	26.63	1	334	3	288	3.0e-29	122	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
649948980	315	24.51	57	307	28	261	2.0e-19	90.1	COG1729	Periplasmic TolA-binding protein (function unknown)	262
649948982	449	30.27	56	447	42	422	5.0e-39	155	COG0823	Periplasmic component of the Tol biopolymer transport system	425
649948984	287	24.89	56	284	38	239	2.0e-07	50.5	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
649948985	141	35.97	1	138	1	134	3.0e-26	111	COG0848	Biopolymer transport protein ExbD	137
649948986	256	34.74	31	239	1	213	4.0e-34	138	COG0811	Biopolymer transport protein ExbB/TolQ	216
649948987	565	42.81	1	563	1	554	9.0e-127	447	COG0497	DNA repair ATPase RecN	557
649948988	340	60.62	22	312	2	293	9.0e-107	380	COG0761	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH	294
649948989	673	30.14	114	662	1	510	1.0e-75	278	COG1657	Squalene cyclase	517
649948990	378	26.77	17	305	8	313	5.0e-25	108	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
649948992	339	24.49	1	328	1	314	7.0e-32	131	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649948994	353	35.57	4	353	1	350	2.0e-59	222	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
649948995	323	22.26	31	298	7	290	5.0e-16	78.8	COG0657	Acetyl esterase/lipase	312
649948999	169	25.48	12	164	10	149	5.0e-19	87.4	COG3832	Uncharacterized conserved protein YndB, AHSA1/START domain	149
649949000	118	30.77	10	98	19	109	3.0e-06	44	COG0640	DNA-binding transcriptional regulator, ArsR family	110
649949001	425	41.01	238	406	2	173	8.0e-30	125	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
649949002	258	32.8	8	255	2	244	1.0e-35	143	COG1587	Uroporphyrinogen-III synthase	248
649949003	275	53.88	66	271	5	209	3.0e-70	258	COG0177	Endonuclease III	211
649949004	285	28.51	52	284	3	229	1.0e-37	150	COG3253	Chlorite dismutase	230
649949005	206	25.24	1	206	3	208	7.0e-25	107	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
649949006	446	25.12	18	409	3	347	5.0e-38	152	COG1260	Myo-inositol-1-phosphate synthase	362
649949007	203	36.32	6	200	8	194	4.0e-41	161	COG0218	GTP-binding protein EngB required for normal cell division	200
649949010	781	22.35	21	264	65	292	2.0e-03	38.1	COG3386	Sugar lactone lactonase YvrE	307
649949014	152	19.11	1	148	8	148	1.0e-03	36.1	COG3088	Cytochrome c-type biogenesis protein CcmH/NrfF	153
649949015	691	33.09	5	677	1	646	4.0e-114	405	COG1138	Cytochrome c biogenesis factor	648
649949017	605	22	9	563	2	490	4.0e-32	133	COG0591	Na+/proline symporter	493
649949020	452	39.19	376	449	1	74	2.0e-11	63.7	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649949021	839	24.61	8	377	1	358	4.0e-34	140	COG0515	Serine/threonine protein kinase	384
649949023	548	63.85	119	544	1	420	0.0e+00	656	COG0148	Enolase	423
649949024	163	23.45	20	157	19	163	2.0e-04	38.9	COG4961	Flp pilus assembly protein TadG	185
649949028	198	38.69	27	194	11	175	1.0e-21	96	COG1268	Biotin transporter BioY	184
649949029	284	46.79	11	275	3	263	2.0e-82	299	COG2107	Predicted periplasmic solute-binding protein	272
649949031	117	28.42	23	117	23	117	2.0e-11	61.1	COG2919	Cell division protein FtsB	117
649949032	272	24.4	4	249	43	286	6.0e-16	78.4	COG0657	Acetyl esterase/lipase	312
649949033	212	30.57	12	168	6	152	2.0e-28	118	COG1853	NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family	176
649949034	282	35.56	15	282	4	246	2.0e-62	232	COG1127	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, ATPase component MlaF	263
649949035	259	43.67	14	258	23	267	3.0e-53	201	COG0767	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, permease component MlaE	267
649949036	353	35.65	1	346	1	350	2.0e-53	202	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
649949037	315	29.43	21	301	3	284	2.0e-38	153	COG1562	Phytoene/squalene synthetase	288
649949038	309	32.23	5	304	5	286	3.0e-44	172	COG1562	Phytoene/squalene synthetase	288
649949039	453	28.57	5	421	3	458	5.0e-41	162	COG3349	Uncharacterized conserved protein, contains NAD-binding domain and a Fe-S cluster	485
649949040	709	26.41	153	590	8	423	9.0e-38	152	COG5267	Uncharacterized conserved protein, DUF1800 family	496
649949041	447	24.61	4	447	8	417	8.0e-44	171	COG4102	Uncharacterized conserved protein, DUF1501 family	418
649949044	496	20	35	469	30	485	1.0e-31	131	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
649949045	468	19.15	1	453	1	453	7.0e-15	75.6	COG1538	Outer membrane protein TolC	457
649949047	606	39.25	39	515	1	445	2.0e-87	316	COG0608	Single-stranded DNA-specific exonuclease, DHH superfamily, may be involved in archaeal DNA replication intiation	491
649949054	281	46.52	10	279	7	279	4.0e-82	297	COG0656	Aldo/keto reductase, related to diketogulonate reductase	280
649949055	494	43.1	21	487	5	472	7.0e-116	411	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
649949057	243	46.86	6	241	8	238	7.0e-45	174	COG0580	Glycerol uptake facilitator and related aquaporins (Major Intrinsic Protein Family)	241
649949058	531	39.89	3	521	1	532	1.0e-129	457	COG0578	Glycerol-3-phosphate dehydrogenase	532
649949059	499	56.97	3	497	5	499	0.0e+00	728	COG0554	Glycerol kinase	499
649949060	783	19.77	105	774	2	617	3.0e-37	150	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
649949062	460	47.94	11	460	5	456	6.0e-120	424	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
649949063	640	22.96	225	615	85	444	6.0e-26	112	COG1538	Outer membrane protein TolC	457
649949064	237	43.36	1	224	1	226	5.0e-65	241	COG1136	ABC-type lipoprotein export system, ATPase component	226
649949065	839	17.32	23	434	5	417	1.0e-11	65.9	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649949066	807	19.04	22	400	4	418	2.0e-15	77.9	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649949067	249	50.89	5	226	1	223	3.0e-76	278	COG1136	ABC-type lipoprotein export system, ATPase component	226
649949068	418	23.87	6	310	7	289	7.0e-13	68.8	COG1566	Multidrug resistance efflux pump	352
649949069	536	31.12	3	435	1	388	4.0e-54	206	COG1696	D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily	425
649949071	289	36.44	44	289	1	245	6.0e-48	184	COG1414	DNA-binding transcriptional regulator, IclR family	246
649949072	544	51.24	51	533	3	445	0.0e+00	529	COG0166	Glucose-6-phosphate isomerase	446
649949073	220	28.09	43	220	4	152	3.0e-19	88.8	COG1225	Peroxiredoxin	157
649949075	725	49.42	384	725	1	324	2.0e-119	423	COG0022	Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component	324
649949077	323	24.5	30	323	19	315	5.0e-25	108	COG0668	Small-conductance mechanosensitive channel	316
649949078	702	39.8	3	698	10	663	0.0e+00	570	COG1331	Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains	667
649949079	461	27.88	1	164	17	175	2.0e-08	54.6	COG2203	GAF domain	175
649949080	726	16.71	277	692	86	457	1.0e-19	92.1	COG1538	Outer membrane protein TolC	457
649949081	258	45.35	1	258	1	244	1.0e-73	269	COG0101	tRNA U38,U39,U40 pseudouridine synthase TruA	266
649949082	418	24.94	42	412	21	406	1.0e-25	111	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
649949083	361	37.13	78	348	20	280	1.0e-61	230	COG1398	Fatty-acid desaturase	289
649949084	296	27.92	10	283	2	302	1.0e-41	163	COG1482	Mannose-6-phosphate isomerase, class I	312
649949085	371	38.13	1	359	1	393	2.0e-96	346	COG0282	Acetate kinase	396
649949086	804	63.22	6	799	6	793	0.0e+00	1140	COG3957	Phosphoketolase	793
649949087	513	44.58	25	512	17	484	0.0e+00	472	COG0260	Leucyl aminopeptidase	485
649949088	179	51.05	36	178	11	153	5.0e-45	174	COG0691	tmRNA-binding protein	153
649949090	165	25.66	14	164	6	144	3.0e-09	54.7	COG2165	Type II secretory pathway, pseudopilin PulG	149
649949096	669	37.84	33	661	2	567	4.0e-127	449	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
649949097	346	46.09	1	340	1	342	9.0e-84	303	COG2008	Threonine aldolase	342
649949100	239	46.72	10	235	3	229	2.0e-59	222	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649949101	458	31.83	6	451	4	447	2.0e-61	229	COG5002	Signal transduction histidine kinase	459
649949102	335	33.44	12	324	34	318	5.0e-53	201	COG0226	ABC-type phosphate transport system, periplasmic component	318
649949103	353	48.87	43	346	8	308	2.0e-70	259	COG0573	ABC-type phosphate transport system, permease component	310
649949104	291	44.84	11	284	8	287	3.0e-63	235	COG0581	ABC-type phosphate transport system, permease component	292
649949105	252	68.27	5	252	8	253	2.0e-118	418	COG1117	ABC-type phosphate transport system, ATPase component	253
649949106	220	34.09	1	219	9	228	2.0e-34	139	COG0704	Phosphate uptake regulator	240
649949107	1165	21.09	14	1152	2	1127	7.0e-70	260	COG1074	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)	1139
649949109	391	23.08	19	381	22	407	1.0e-21	97.6	COG0738	Fucose permease	422
649949110	324	25.71	150	320	40	202	7.0e-20	91.6	COG1999	Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family	207
649949112	633	39.34	42	613	1	566	1.0e-125	444	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
649949115	675	20.93	107	483	80	464	2.0e-10	61.7	COG1807	4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of PMT family	535
649949117	257	30.56	26	180	42	218	4.0e-16	78.4	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
649949118	410	23.81	23	399	14	387	3.0e-23	102	COG2814	Predicted arabinose efflux permease, MFS family	394
649949120	470	28.6	16	463	13	401	3.0e-56	213	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
649949121	187	35.45	1	184	3	190	5.0e-34	137	COG0746	Molybdopterin-guanine dinucleotide biosynthesis protein A	192
649949122	324	46.41	80	315	9	245	3.0e-66	245	COG1127	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, ATPase component MlaF	263
649949123	501	43.4	269	501	1	225	4.0e-62	232	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
649949124	570	23.9	1	270	2	243	3.0e-30	127	COG0388	Predicted amidohydrolase	274
649949124	570	41.67	291	557	4	264	3.0e-67	249	COG0171	NH3-dependent NAD+ synthetase	268
649949126	565	37.24	17	551	1	496	2.0e-121	429	COG3046	Uncharacterized protein related to deoxyribodipyrimidine photolyase	505
649949127	193	29.3	22	174	19	175	6.0e-18	84	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649949128	388	31.3	4	386	16	400	2.0e-55	210	COG3844	Kynureninase	407
649949129	465	42.11	10	461	1	452	3.0e-105	376	COG1113	L-asparagine transporter and related permeases	462
649949131	135	18.46	1	128	1	129	2.0e-11	61.5	COG1765	Uncharacterized OsmC-related protein	137
649949133	314	35.11	2	314	11	326	1.0e-62	233	COG4977	Transcriptional regulator GlxA family, contains an amidase domain and an AraC-type DNA-binding HTH domain	328
649949137	739	36.4	3	736	14	747	0.0e+00	502	COG3537	Putative alpha-1,2-mannosidase	768
649949142	416	23.53	21	410	14	391	3.0e-20	93	COG2814	Predicted arabinose efflux permease, MFS family	394
649949143	391	25.65	43	364	47	383	2.0e-20	93.8	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
649949144	450	45.02	4	405	1	357	4.0e-122	431	COG0821	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE	361
649949146	412	15.45	136	379	1	228	3.0e-04	40	COG2202	PAS domain	232
649949147	109	28.79	32	97	8	73	8.0e-07	45.6	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649949148	813	26.6	1	374	1	364	3.0e-43	170	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
649949149	335	33.13	1	332	3	336	1.0e-75	276	COG2055	Malate/lactate/ureidoglycolate dehydrogenase, LDH2 family	349
649949151	256	43.7	11	253	1	250	1.0e-47	183	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649949152	151	28.28	6	150	1	128	3.0e-14	71.5	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
649949154	274	44.15	4	267	1	265	9.0e-71	260	COG0300	Short-chain dehydrogenase	265
649949155	195	25	5	176	11	180	3.0e-11	62	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649949157	285	50.18	18	285	2	278	1.0e-96	346	COG3717	5-keto 4-deoxyuronate isomerase	278
649949158	388	26	41	382	1	310	6.0e-25	108	COG0524	Sugar or nucleoside kinase, ribokinase family	311
649949159	219	45.02	1	211	1	211	4.0e-54	204	COG0800	2-keto-3-deoxy-6-phosphogluconate aldolase	211
649949161	311	21.4	5	238	9	246	7.0e-09	55	COG0834	ABC-type amino acid transport/signal transduction system, periplasmic component/domain	275
649949162	648	19.44	43	506	35	467	5.0e-14	73.4	COG3511	Phospholipase C	527
649949167	213	25.77	8	188	47	240	2.0e-08	52.6	COG0428	Zinc transporter ZupT	266
649949169	575	23.26	19	530	3	487	3.0e-39	156	COG0591	Na+/proline symporter	493
649949171	322	25.87	30	303	34	310	1.0e-14	74.2	COG1612	Heme A synthase	323
649949172	301	45.83	36	299	3	264	7.0e-64	237	COG0345	Pyrroline-5-carboxylate reductase	266
649949177	153	34.13	18	142	1	126	4.0e-11	61.1	COG1846	DNA-binding transcriptional regulator, MarR family	126
649949178	413	53.17	5	412	4	411	0.0e+00	468	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
649949179	352	35.04	1	351	1	286	4.0e-66	245	COG0812	UDP-N-acetylenolpyruvoylglucosamine reductase	291
649949181	221	41.2	1	216	4	219	6.0e-47	180	COG4149	ABC-type molybdate transport system, permease component	225
649949182	252	29.84	2	250	1	256	2.0e-37	148	COG0725	ABC-type molybdate transport system, periplasmic component	258
649949183	464	38.05	5	410	4	377	4.0e-81	295	COG0498	Threonine synthase	411
649949187	258	23.77	16	250	10	248	6.0e-12	64.9	COG1922	UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family	253
649949188	329	31.68	7	322	2	311	3.0e-42	165	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649949189	300	53.96	19	294	11	287	2.0e-75	275	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
649949190	157	33.95	6	153	3	164	2.0e-21	95.1	COG0622	Predicted phosphodiesterase	172
649949191	319	49.36	8	313	6	317	1.0e-87	317	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
649949192	471	38.83	5	445	3	419	4.0e-91	328	COG1253	Hemolysin or related protein, contains CBS domains	429
649949194	287	37.4	1	258	1	261	2.0e-56	212	COG0083	Homoserine kinase	299
649949195	423	34.42	23	413	4	399	2.0e-70	260	COG3434	c-di-GMP-related signal transduction protein, contains EAL and HDOD domains	407
649949196	344	36.54	1	340	1	350	3.0e-72	265	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
649949197	234	28.99	21	176	17	185	1.0e-23	103	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
649949198	246	30.1	21	223	7	209	2.0e-21	96.6	COG3222	Uncharacterized conserved protein, glycosyltransferase A (GT-A) superfamily, DUF2064 family	211
649949200	377	25.15	37	374	1	316	1.0e-27	117	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
649949205	599	28.66	139	595	3	475	2.0e-70	260	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649949207	201	19.68	8	192	3	184	4.0e-03	35	COG3637	Opacity protein and related surface antigens	199
649949208	661	25.71	282	661	26	366	1.0e-36	148	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
649949210	253	51.54	20	245	4	226	2.0e-64	238	COG0274	Deoxyribose-phosphate aldolase	228
649949211	521	37.24	327	516	9	201	8.0e-34	138	COG1573	Uracil-DNA glycosylase	202
649949212	411	54.43	2	401	1	404	0.0e+00	496	COG4277	Predicted DNA-binding protein with the Helix-hairpin-helix motif	404
649949213	293	27.19	54	277	30	244	4.0e-17	82.3	COG0327	Putative GTP cyclohydrolase 1 type 2, NIF3 family	250
649949214	200	35.9	24	178	1	151	5.0e-31	127	COG0782	Transcription elongation factor, GreA/GreB family	151
649949216	194	52.35	22	191	9	178	1.0e-59	222	COG0634	Hypoxanthine-guanine phosphoribosyltransferase	178
649949217	288	23.27	5	268	16	270	8.0e-14	71.4	COG0682	Prolipoprotein diacylglyceryltransferase	287
649949223	1003	48.86	10	992	1	935	0.0e+00	1188	COG0178	Excinuclease UvrABC ATPase subunit	935
649949224	740	34.97	65	405	50	364	1.0e-58	221	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
649949226	630	20.83	200	630	27	501	2.0e-32	134	COG3534	Alpha-L-arabinofuranosidase	501
649949228	686	28.63	249	683	43	501	7.0e-62	232	COG3534	Alpha-L-arabinofuranosidase	501
649949229	272	23.81	62	248	41	228	2.0e-08	53	COG3063	Tfp pilus assembly protein PilF	250
649949236	339	40.18	1	335	1	333	2.0e-83	303	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
649949243	343	35.4	3	316	1	316	5.0e-57	215	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
649949244	420	25.34	53	420	1	340	1.0e-41	164	COG0673	Predicted dehydrogenase	342
649949245	895	25.25	63	458	47	397	3.0e-40	160	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
649949246	218	28.71	1	207	2	209	4.0e-24	104	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649949248	356	34.38	1	344	6	356	3.0e-63	235	COG1060	2-iminoacetate synthase ThiH (tyrosine cleavage enzyme, thamine biosynthesis)	370
649949249	643	21.78	1	612	28	585	3.0e-26	113	COG4206	Outer membrane cobalamin receptor protein	608
649949250	905	14.14	149	728	81	660	2.0e-07	51.8	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
649949252	125	33.61	6	124	18	139	2.0e-22	97.7	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
649949253	455	23.11	18	449	1	435	5.0e-17	82.5	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
649949255	2626	37.61	1790	2427	1	642	7.0e-122	433	COG1020	Non-ribosomal peptide synthetase component F	642
649949255	2626	43.1	6	882	3	878	0.0e+00	737	COG3321	Acyl transferase domain in polyketide synthase (PKS) enzymes	1061
649949256	1366	37.99	270	913	1	642	5.0e-127	449	COG1020	Non-ribosomal peptide synthetase component F	642
649949259	359	24.93	1	349	7	363	1.0e-14	74	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649949260	437	26.56	75	434	10	378	3.0e-33	136	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649949261	350	32.79	28	330	4	291	1.0e-42	167	COG1216	Glycosyltransferase, GT2 family	305
649949262	200	29.34	29	195	13	179	2.0e-21	95.7	COG0110	Acetyltransferase (isoleucine patch superfamily)	190
649949264	180	35.79	1	177	3	184	6.0e-33	133	COG1045	Serine acetyltransferase	194
649949265	1202	20	34	463	17	456	9.0e-18	86.7	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
649949266	350	24.9	34	273	21	236	6.0e-15	75.5	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
649949267	401	40.57	1	243	2	242	9.0e-61	227	COG1922	UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family	253
649949271	230	44.59	1	230	8	234	1.0e-55	210	COG3208	Surfactin synthase thioesterase subunit	244
649949272	394	22.08	1	381	6	402	4.0e-21	96.2	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
649949276	471	28	60	352	54	346	4.0e-25	109	COG1566	Multidrug resistance efflux pump	352
649949277	253	53.57	22	243	1	224	7.0e-84	303	COG1136	ABC-type lipoprotein export system, ATPase component	226
649949282	539	32.88	181	535	99	465	1.0e-29	125	COG0531	Amino acid transporter	466
649949283	492	29.18	17	484	20	450	1.0e-28	121	COG0531	Amino acid transporter	466
649949284	234	39.71	1	204	5	190	7.0e-34	137	COG0352	Thiamine monophosphate synthase	211
649949285	451	61.07	1	446	1	446	0.0e+00	597	COG0439	Biotin carboxylase	449
649949286	174	33.54	10	173	1	140	4.0e-21	94.4	COG0511	Biotin carboxyl carrier protein	140
649949287	361	38.83	5	361	12	383	4.0e-73	268	COG0006	Xaa-Pro aminopeptidase	384
649949288	298	36.05	22	297	3	283	6.0e-43	167	COG1408	Predicted phosphohydrolase, MPP superfamily	284
649949290	338	28.41	60	319	1	256	2.0e-34	139	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
649949291	309	30.71	35	308	23	297	2.0e-49	189	COG3735	Uncharacterized conserved protein YbaP, TraB family	299
649949293	595	40.2	10	589	22	610	0.0e+00	519	COG1022	Long-chain acyl-CoA synthetase (AMP-forming)	613
649949294	1516	49.52	706	1225	6	483	0.0e+00	536	COG0069	Glutamate synthase domain 2	485
649949295	146	33.33	1	145	3	150	7.0e-28	116	COG1438	Arginine repressor	150
649949296	362	42.94	11	361	2	342	1.0e-99	356	COG0002	N-acetyl-gamma-glutamylphosphate reductase	349
649949297	260	44.79	3	257	5	263	4.0e-57	215	COG0548	Acetylglutamate kinase	265
649949298	411	43.53	1	401	4	404	1.0e-129	456	COG4992	Acetylornithine/succinyldiaminopimelate/putrescine aminotransferase	404
649949299	357	51.94	31	338	1	310	1.0e-106	379	COG0078	Ornithine carbamoyltransferase	310
649949300	446	34.52	8	428	1	403	7.0e-124	437	COG0137	Argininosuccinate synthase	403
649949301	493	47.34	5	492	1	458	0.0e+00	492	COG0165	Argininosuccinate lyase	459
649949302	198	35.33	21	168	2	150	2.0e-25	109	COG1246	N-acetylglutamate synthase or related acetyltransferase, GNAT family	153
649949303	258	35.78	1	227	28	255	4.0e-49	188	COG1119	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA	257
649949304	306	41.33	6	302	4	300	2.0e-74	272	COG3643	Glutamate formiminotransferase	302
649949306	246	53.94	1	241	1	241	4.0e-91	327	COG0217	Transcriptional and/or translational regulatory protein YebC/TACO1	241
649949307	433	47.36	19	410	3	394	1.0e-112	400	COG0019	Diaminopimelate decarboxylase	394
649949309	92	41.49	1	92	1	94	4.0e-17	79.5	COG3549	Plasmid maintenance system killer protein	94
649949310	95	37.76	3	95	1	98	2.0e-19	87.3	COG3093	Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain	104
649949311	109	40.98	35	93	4	64	4.0e-12	63.3	COG1983	Phage shock protein PspC (stress-responsive transcriptional regulator)	70
649949312	159	33.79	11	155	6	149	1.0e-19	89.6	COG4846	Membrane protein CcdC involved in cytochrome C biogenesis	163
649949318	91	25	23	85	8	71	1.0e-05	41.1	COG2442	Uncharacterized conserved protein, DUF433 family	79
649949320	680	36.8	1	498	1	477	8.0e-103	368	COG2812	DNA polymerase III, gamma/tau subunits	515
649949321	108	35.35	7	102	5	101	7.0e-14	69.1	COG0718	Conserved DNA-binding protein YbaB (function unknown)	105
649949322	200	52.26	4	200	2	198	1.0e-68	252	COG0353	Recombinational DNA repair protein RecR	198
649949324	157	36	2	145	1	143	2.0e-15	75.4	COG2405	Predicted nucleic acid-binding protein, contains PIN domain	157
649949325	534	52.27	1	528	2	507	0.0e+00	631	COG0696	Phosphoglycerate mutase (BPG-independent, AlkP superfamily)	509
649949329	639	20.69	80	608	15	580	8.0e-45	175	COG3250	Beta-galactosidase/beta-glucuronidase	808
649949334	317	28.51	18	258	5	226	3.0e-24	106	COG0300	Short-chain dehydrogenase	265
649949335	136	35.29	32	133	20	119	6.0e-18	83.1	COG1733	DNA-binding transcriptional regulator, HxlR family	120
649949350	157	27.01	28	146	29	164	2.0e-10	58.6	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649949355	555	29.39	10	555	1	542	2.0e-101	363	COG4626	Phage terminase-like protein, large subunit, contains N-terminal HTH domain	546
649949356	448	30.56	31	399	22	378	2.0e-60	227	COG4695	Phage portal protein BeeE	398
649949357	250	37.08	19	187	14	190	6.0e-32	131	COG3740	Phage head maturation protease	194
649949376	150	45.52	7	148	8	151	8.0e-31	126	COG3772	Phage-related lysozyme (muramidase), GH24 family	152
649949380	426	23.75	110	404	1	281	6.0e-21	95.7	COG4974	Site-specific recombinase XerD	300
649949390	83	29.17	11	82	5	75	2.0e-07	47.1	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649949391	296	23.02	2	277	34	299	3.0e-13	69.1	COG4974	Site-specific recombinase XerD	300
649949392	414	29.59	120	405	6	292	2.0e-30	127	COG4974	Site-specific recombinase XerD	300
649949393	289	33.62	41	269	17	249	1.0e-43	170	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
649949396	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649949400	200	34.87	50	195	51	199	2.0e-24	105	COG3764	Sortase (surface protein transpeptidase)	210
649949402	110	27.17	12	101	2	93	3.0e-04	36.9	COG1396	Transcriptional regulator, contains XRE-family HTH domain	120
649949403	386	42.94	56	386	1	318	4.0e-78	285	COG2826	Transposase and inactivated derivatives, IS30 family	318
649949406	89	58.82	3	69	1	67	3.0e-17	80.2	COG1278	Cold shock protein, CspA family	67
649949409	71	50.77	5	68	3	67	4.0e-17	79.8	COG1278	Cold shock protein, CspA family	67
649949410	82	34.25	10	81	3	75	2.0e-09	54	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649949411	208	25.65	6	194	1	191	2.0e-18	86	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649949420	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649949424	352	23.39	106	340	45	288	4.0e-22	99.1	COG4974	Site-specific recombinase XerD	300
649949426	781	33.19	548	780	54	290	1.0e-19	92.5	COG0741	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)	296
649949428	213	40.22	18	201	1	177	2.0e-31	129	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649949432	181	44.07	9	178	2	175	1.0e-45	176	COG2087	Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase	175
649949433	491	48.36	8	464	2	449	0.0e+00	527	COG1797	Cobyrinic acid a,c-diamide synthase	451
649949434	348	41.38	3	343	1	334	4.0e-67	248	COG2038	NaMN:DMB phosphoribosyltransferase	347
649949437	193	34.78	1	180	2	185	2.0e-31	129	COG0406	Broad specificity phosphatase PhoE	208
649949439	195	41.76	1	182	5	178	4.0e-36	144	COG2096	Cob(I)alamin adenosyltransferase	184
649949440	538	48.3	3	529	1	486	0.0e+00	574	COG1492	Cobyric acid synthase	486
649949441	342	43.93	41	333	12	314	2.0e-67	249	COG1270	Cobalamin biosynthesis protein CobD/CbiB	320
649949442	415	27.88	5	415	7	352	2.0e-55	210	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
649949443	346	55.9	14	335	19	337	1.0e-103	370	COG3376	High-affinity nickel permease	342
649949444	674	28.28	5	674	3	577	2.0e-87	317	COG0018	Arginyl-tRNA synthetase	577
649949448	405	34.57	26	394	5	350	3.0e-57	216	COG3405	Endo-1,4-beta-D-glucanase Y	360
649949449	1516	23.69	102	571	3	430	4.0e-48	187	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
649949450	577	22.58	330	560	5	252	5.0e-22	99.9	COG1192	Cellulose biosynthesis protein BcsQ	259
649949452	407	19.78	26	375	17	371	5.0e-14	72.6	COG0439	Biotin carboxylase	449
649949453	495	49.79	16	485	8	463	0.0e+00	492	COG2870	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase	467
649949454	367	23.96	8	361	1	332	6.0e-27	115	COG0859	ADP-heptose:LPS heptosyltransferase	334
649949457	682	39.5	9	367	2	337	1.0e-68	254	COG1600	Epoxyqueuosine reductase  QueG (queuosine biosynthesis)	337
649949458	410	35.95	5	391	1	367	2.0e-80	293	COG0763	Lipid A disaccharide synthetase	381
649949460	209	25.23	1	208	1	210	1.0e-13	69.9	COG2910	Putative NADH-flavin reductase	211
649949461	64	23.08	1	60	3	67	1.0e-06	44.6	COG2608	Copper chaperone CopZ	71
649949462	734	42.45	1	734	1	711	0.0e+00	644	COG2217	Cation transport ATPase	713
649949463	279	36.36	1	264	1	261	3.0e-59	222	COG1606	ATP-utilizing enzyme, PP-loop superfamily	269
649949464	443	38.91	2	443	1	382	1.0e-98	353	COG1641	Uncharacterized conserved protein, DUF111 family	387
649949465	257	51.2	9	255	6	251	4.0e-67	248	COG1691	NCAIR mutase (PurE)-related protein	254
649949467	258	39.76	6	252	1	251	6.0e-46	177	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649949468	169	46.88	6	165	1	157	6.0e-46	176	COG3265	Gluconate kinase	161
649949472	143	27.34	1	137	1	135	3.0e-11	61.3	COG1848	Predicted nucleic acid-binding protein, contains PIN domain	140
649949473	469	41.89	2	469	3	461	0.0e+00	547	COG1904	Glucuronate isomerase	463
649949477	376	41.88	1	373	1	375	1.0e-89	323	COG1820	N-acetylglucosamine-6-phosphate deacetylase	380
649949478	1510	23.11	24	540	5	493	5.0e-50	194	COG0591	Na+/proline symporter	493
649949479	225	35.02	1	216	8	224	4.0e-31	128	COG0704	Phosphate uptake regulator	240
649949480	701	43.53	26	700	5	682	0.0e+00	764	COG0339	Zn-dependent oligopeptidase	683
649949483	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649949484	410	35.63	3	405	18	396	3.0e-60	226	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
649949486	582	32.64	25	550	8	500	9.0e-101	361	COG0155	Sulfite reductase, beta subunit (hemoprotein)	510
649949487	982	26.92	60	489	29	451	2.0e-61	231	COG0076	Glutamate or tyrosine decarboxylase or a related PLP-dependent protein	460
649949488	211	17.93	26	208	9	192	2.0e-06	46.2	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649949489	207	40.46	1	172	1	171	3.0e-46	178	COG1182	FMN-dependent NADH-azoreductase	202
649949491	189	28.11	6	189	2	186	7.0e-19	87	COG2020	Protein-S-isoprenylcysteine O-methyltransferase Ste14	187
649949494	220	38.3	1	188	1	188	1.0e-44	173	COG1648	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)	210
649949495	266	47.26	32	265	2	235	2.0e-61	229	COG0007	Uroporphyrinogen-III methylase (siroheme synthase)	244
649949496	209	35.97	68	206	2	138	6.0e-24	104	COG1661	Predicted DNA-binding protein with PD1-like DNA-binding motif	141
649949497	252	41.13	17	246	33	262	1.0e-58	219	COG3186	Phenylalanine-4-hydroxylase	291
649949498	416	23.18	31	411	28	394	2.0e-15	77.6	COG2814	Predicted arabinose efflux permease, MFS family	394
649949500	219	45.95	33	216	4	187	5.0e-42	164	COG2353	Polyisoprenoid-binding periplasmic protein YceI	192
649949501	255	25.82	25	235	1	209	7.0e-31	127	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649949504	366	20.16	39	366	8	381	2.0e-26	113	COG2309	Leucyl aminopeptidase (aminopeptidase T)	385
649949505	368	37.15	3	357	1	356	3.0e-82	299	COG2170	Gamma-glutamyl:cysteine ligase YbdK, ATP-grasp superfamily	369
649949506	1055	44.31	1	1042	2	1009	0.0e+00	925	COG0841	Multidrug efflux pump subunit AcrB	1009
649949507	358	27.87	1	355	5	366	1.0e-25	110	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
649949509	392	43.23	1	381	11	393	8.0e-71	261	COG2814	Predicted arabinose efflux permease, MFS family	394
649949510	335	45.15	1	324	1	306	5.0e-79	288	COG3684	Tagatose-1,6-bisphosphate aldolase	306
649949512	527	67.48	202	527	1	315	0.0e+00	533	COG0519	GMP synthase, PP-ATPase domain/subunit	315
649949515	855	49.58	28	854	4	814	0.0e+00	964	COG0495	Leucyl-tRNA synthetase	814
649949516	439	20.05	30	432	28	455	2.0e-20	94.2	COG0277	FAD/FMN-containing dehydrogenase	459
649949518	288	36.09	5	268	1	259	5.0e-62	231	COG0648	Endonuclease IV	280
649949522	459	23.06	1	459	21	463	6.0e-25	109	COG0531	Amino acid transporter	466
649949523	951	27.08	58	244	2	177	1.0e-12	69.3	COG2120	N-acetylglucosaminyl deacetylase, LmbE family	237
649949524	263	24.9	13	262	3	261	2.0e-22	99.6	COG3971	2-keto-4-pentenoate hydratase	264
649949525	334	38.19	1	308	2	277	5.0e-57	215	COG1273	Non-homologous end joining protein Ku, dsDNA break repair	278
649949526	914	47.7	624	902	9	287	8.0e-81	295	COG3285	Eukaryotic-type DNA primase	299
649949527	238	33.04	1	222	14	222	2.0e-28	119	COG2120	N-acetylglucosaminyl deacetylase, LmbE family	237
649949528	247	49.48	35	223	2	192	9.0e-56	210	COG0164	Ribonuclease HII	199
649949529	118	60	5	113	4	113	9.0e-32	128	COG0335	Ribosomal protein L19	115
649949530	272	50.75	1	266	1	240	2.0e-91	329	COG0336	tRNA G37 N-methylase TrmD	240
649949531	202	32.12	1	190	2	174	6.0e-23	101	COG0806	Ribosomal 30S subunit maturation factor RimM, required for 16S rRNA processing	174
649949532	103	44.74	17	92	1	76	1.0e-13	68.3	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649949533	83	44.58	2	83	4	86	7.0e-17	78.7	COG0228	Ribosomal protein S16	87
649949534	324	22.89	87	324	22	262	7.0e-25	108	COG2819	Predicted hydrolase of the alpha/beta superfamily	264
649949535	236	39.83	1	236	1	227	7.0e-59	220	COG4947	Esterase/lipase superfamily enzyme	227
649949536	350	20.39	28	268	59	292	8.0e-10	58.5	COG0189	Glutathione synthase/RimK-type ligase, ATP-grasp superfamily	318
649949537	770	47.1	85	766	8	683	0.0e+00	749	COG0855	Polyphosphate kinase	696
649949539	608	37.56	38	440	4	393	1.0e-77	284	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
649949540	394	43.28	1	392	1	392	2.0e-89	323	COG0183	Acetyl-CoA acetyltransferase	392
649949541	818	37.29	8	307	3	293	2.0e-67	251	COG1250	3-hydroxyacyl-CoA dehydrogenase	307
649949543	509	26.27	17	499	7	436	4.0e-58	219	COG0612	Predicted Zn-dependent peptidase	438
649949544	498	24.59	43	461	6	430	3.0e-61	229	COG0612	Predicted Zn-dependent peptidase	438
649949545	177	24.34	1	137	2	152	2.0e-10	59.1	COG4636	Endonuclease, Uma2 family (restriction endonuclease fold)	200
649949546	474	50.65	6	464	4	457	0.0e+00	542	COG1207	Bifunctional protein GlmU, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase	460
649949547	366	39.82	5	339	16	350	1.0e-68	253	COG3437	Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains	360
649949548	94	44.21	1	93	3	97	9.0e-23	98.4	COG2154	Pterin-4a-carbinolamine dehydratase	101
649949550	139	47.45	1	137	2	138	2.0e-27	114	COG2510	Uncharacterized membrane protein	140
649949554	544	25.24	20	523	18	508	4.0e-58	219	COG0815	Apolipoprotein N-acyltransferase	518
649949555	299	30.04	16	278	13	270	1.0e-28	120	COG3336	Cytochrome c oxidase assembly factor CtaG	299
649949556	520	30.98	21	387	6	354	4.0e-52	199	COG1290	Cytochrome b subunit of the bc complex	381
649949557	241	23.84	30	193	1	169	2.0e-11	63.3	COG0723	Rieske Fe-S protein	177
649949558	248	23.48	26	138	37	143	3.0e-04	39.2	COG2010	Cytochrome c, mono- and diheme variants	150
649949560	200	34.07	21	199	29	207	5.0e-29	120	COG1845	Heme/copper-type cytochrome/quinol oxidase, subunit 3	209
649949561	566	50.76	33	557	10	530	0.0e+00	531	COG0843	Heme/copper-type cytochrome/quinol oxidase, subunit 1	566
649949562	340	34.6	33	242	22	224	6.0e-46	178	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	247
649949570	756	28.68	9	142	6	139	5.0e-17	83.9	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	148
649949571	162	43.75	9	152	16	155	9.0e-33	133	COG1956	GAF domain-containing protein, putative methionine-R-sulfoxide reductase	163
649949572	621	29.77	1	212	10	217	7.0e-27	115	COG0785	Cytochrome c biogenesis protein CcdA	220
649949573	194	51.97	69	194	4	130	3.0e-53	201	COG0229	Peptide methionine sulfoxide reductase MsrB	140
649949574	360	26.74	42	360	28	363	1.0e-28	121	COG4638	Phenylpropionate dioxygenase or related ring-hydroxylating dioxygenase, large terminal subunit	367
649949575	443	30.68	14	419	15	438	3.0e-51	196	COG0038	H+/Cl- antiporter ClcA	443
649949577	429	46.12	13	412	4	413	1.0e-79	290	COG0738	Fucose permease	422
649949579	768	37.63	40	767	42	759	0.0e+00	606	COG3537	Putative alpha-1,2-mannosidase	768
649949580	788	26.41	281	674	2	387	2.0e-62	234	COG0247	Fe-S oxidoreductase	388
649949581	316	47.48	1	316	2	312	1.0e-75	277	COG2025	Electron transfer flavoprotein, alpha subunit	313
649949582	251	37.93	1	251	1	260	1.0e-51	197	COG2086	Electron transfer flavoprotein, alpha and beta subunits	260
649949583	254	37.64	1	250	1	251	1.0e-30	126	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649949584	490	47.58	7	479	2	453	4.0e-124	438	COG2079	2-methylcitrate dehydratase PrpD	453
649949585	385	46.46	11	384	13	390	8.0e-110	390	COG0372	Citrate synthase	390
649949586	296	56.55	1	290	1	289	3.0e-91	328	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	289
649949587	437	18.85	20	427	29	439	2.0e-07	51	COG2271	Sugar phosphate permease	448
649949588	72	40.85	1	71	1	68	9.0e-10	55.2	COG2104	Sulfur carrier protein ThiS (thiamine biosynthesis)	68
649949590	267	46.77	1	262	3	263	2.0e-66	245	COG0351	Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	263
649949591	237	49.78	8	234	11	234	1.0e-54	206	COG0284	Orotidine-5'-phosphate decarboxylase	240
649949592	302	33.83	32	294	5	267	9.0e-53	200	COG1834	N-Dimethylarginine dimethylaminohydrolase	267
649949595	351	22.83	22	237	11	226	1.0e-03	38	COG1266	Membrane protease YdiL, CAAX protease family	226
649949596	282	61.92	19	278	56	315	9.0e-104	369	COG0825	Acetyl-CoA carboxylase alpha subunit	317
649949597	148	21.9	1	133	7	137	3.0e-03	35	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
649949599	1176	47.29	4	1138	3	1108	0.0e+00	1219	COG0587	DNA polymerase III, alpha subunit	1139
649949604	345	27.54	4	342	14	406	1.0e-31	131	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
649949605	229	37.97	15	199	11	191	2.0e-33	136	COG2945	Alpha/beta superfamily hydrolase	210
649949606	273	30.07	5	273	2	281	3.0e-23	102	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649949608	475	46.67	14	474	1	463	0.0e+00	509	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
649949611	324	35.57	44	324	54	313	2.0e-45	176	COG1262	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain	314
649949612	356	27.06	28	353	2	336	3.0e-36	146	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
649949614	246	47.6	3	243	2	249	7.0e-42	164	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649949615	673	23.17	268	660	13	400	8.0e-23	102	COG1228	Imidazolonepropionase or related amidohydrolase	406
649949616	759	24.28	20	746	1	617	7.0e-68	252	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
649949617	300	23.35	1	222	1	221	2.0e-09	56.5	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
649949619	161	45.12	1	160	1	164	3.0e-39	154	COG4702	Uncharacterized protein, UPF0303 family	168
649949623	318	44.38	1	317	1	305	6.0e-87	314	COG0181	Porphobilinogen deaminase	307
649949625	216	37.69	10	208	4	198	9.0e-31	126	COG2860	Uncharacterized membrane protein YeiH	209
649949626	467	49.87	72	462	17	409	2.0e-110	392	COG2262	50S ribosomal subunit-associated GTPase HflX	411
649949627	482	44.44	19	215	25	220	1.0e-33	138	COG1357	Uncharacterized protein YjbI, contains pentapeptide repeats	238
649949629	142	21.9	1	136	1	135	3.0e-10	58	COG1569	Predicted nucleic acid-binding protein, contains PIN domain	142
649949630	424	42.89	14	421	2	392	3.0e-107	382	COG0373	Glutamyl-tRNA reductase	414
649949631	270	26.09	1	252	1	248	4.0e-17	82.2	COG4137	ABC-type uncharacterized transport system, permease component	265
649949632	474	24.94	59	454	1	400	2.0e-48	187	COG3669	Alpha-L-fucosidase	430
649949635	902	43.75	9	897	4	842	0.0e+00	833	COG0249	DNA mismatch repair ATPase MutS	843
649949636	389	34.7	1	386	5	367	9.0e-64	237	COG2377	1,6-Anhydro-N-acetylmuramate kinase	371
649949637	501	30.38	15	501	37	554	1.0e-78	287	COG0747	ABC-type transport system, periplasmic component	556
649949641	317	24.7	62	305	2	220	2.0e-16	80.2	COG3039	Transposase and inactivated derivatives, IS5 family	230
649949643	297	34.25	11	291	5	288	2.0e-53	202	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
649949645	209	52.63	1	209	14	219	4.0e-47	181	COG1174	ABC-type proline/glycine betaine transport system, permease component	221
649949646	251	49.39	6	248	2	242	4.0e-73	268	COG1125	ABC-type proline/glycine betaine transport system, ATPase component	309
649949647	317	36.43	138	272	4	142	1.0e-19	90.4	COG4639	Predicted kinase	168
649949648	335	61.7	2	327	1	327	9.0e-122	429	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	335
649949649	135	36.75	14	124	14	129	2.0e-17	81.5	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
649949650	405	59.07	1	404	2	393	0.0e+00	502	COG0126	3-phosphoglycerate kinase	395
649949652	252	46.22	1	250	1	247	2.0e-77	281	COG0149	Triosephosphate isomerase	251
649949654	186	25.16	21	177	7	161	2.0e-12	65.8	COG0681	Signal peptidase I	166
649949655	326	47.26	30	321	4	295	2.0e-89	322	COG2103	N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase	298
649949657	426	57.68	1	421	1	420	0.0e+00	575	COG0766	UDP-N-acetylglucosamine enolpyruvyl transferase	421
649949658	189	22.63	1	184	7	173	5.0e-18	84.3	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
649949659	387	44.13	23	376	6	363	2.0e-103	370	COG1060	2-iminoacetate synthase ThiH (tyrosine cleavage enzyme, thamine biosynthesis)	370
649949660	757	22.75	95	345	53	300	1.0e-08	55.8	COG4447	Uncharacterized protein related to plant photosystem II stability/assembly factor	339
649949662	205	57.49	36	201	5	170	1.0e-65	242	COG0377	NADH:ubiquinone oxidoreductase 20 kD subunit (chhain B) or related Fe-S oxidoreductase	194
649949664	891	31.58	44	890	43	865	1.0e-116	414	COG2844	UTP:GlnB (protein PII) uridylyltransferase	867
649949665	112	67.86	1	112	1	112	1.0e-34	138	COG0347	Nitrogen regulatory protein PII	112
649949666	483	56.14	67	480	1	403	1.0e-113	403	COG0004	Ammonia channel protein AmtB	409
649949668	306	25.86	1	281	6	293	2.0e-22	100	COG0657	Acetyl esterase/lipase	312
649949669	164	20.41	18	163	1	136	4.0e-06	44.5	COG2246	Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose)	139
649949670	203	47.46	1	177	1	175	1.0e-53	202	COG0279	Phosphoheptose isomerase	176
649949671	705	48.8	1	703	8	691	0.0e+00	781	COG1523	Pullulanase/glycogen debranching enzyme	697
649949672	588	41.99	46	503	25	474	4.0e-111	395	COG0539	Ribosomal protein S1	541
649949675	865	31.87	7	864	5	828	5.0e-122	432	COG3127	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component	829
649949676	145	28.57	2	141	1	131	3.0e-17	81.4	COG1487	Predicted nucleic acid-binding protein, contains PIN domain	133
649949678	247	51.1	16	241	1	226	2.0e-75	275	COG1136	ABC-type lipoprotein export system, ATPase component	226
649949679	247	26.7	67	247	9	214	7.0e-20	91.1	COG2755	Lysophospholipase L1 or related esterase	216
649949680	294	34.29	1	280	11	257	1.0e-54	206	COG0130	tRNA U55 pseudouridine synthase TruB, may also work on U342 of tmRNA	271
649949681	196	60	14	193	16	195	8.0e-71	259	COG0302	GTP cyclohydrolase I	195
649949682	141	26.32	6	132	5	124	2.0e-11	62.3	COG0720	6-pyruvoyl-tetrahydropterin synthase	127
649949683	146	32.14	1	135	2	127	7.0e-19	86.5	COG0720	6-pyruvoyl-tetrahydropterin synthase	127
649949685	149	25.56	15	131	5	136	6.0e-10	56.8	COG1225	Peroxiredoxin	157
649949693	422	21.18	5	420	5	400	9.0e-27	115	COG4393	Uncharacterized membrane protein	405
649949694	447	21.08	14	444	1	417	9.0e-17	81.7	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649949695	362	19.8	6	362	5	408	8.0e-15	74.9	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
649949696	249	52.04	22	237	1	221	3.0e-74	272	COG1136	ABC-type lipoprotein export system, ATPase component	226
649949702	322	20.32	52	222	18	197	9.0e-08	51.4	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
649949703	305	32.06	1	284	1	283	5.0e-40	158	COG0583	DNA-binding transcriptional regulator, LysR family	297
649949705	258	44.3	75	222	5	153	1.0e-40	160	COG0386	Glutathione peroxidase, house-cleaning role in reducing lipid peroxides	162
649949706	600	34.49	1	445	7	467	2.0e-90	327	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649949709	220	38.35	19	218	48	247	3.0e-44	172	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	264
649949710	240	24.89	1	230	37	263	1.0e-20	93.5	COG3665	Uncharacterized conserved protein YcgI, DUF1989 family	264
649949712	386	19.35	23	357	1	324	6.0e-12	65.6	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	335
649949713	286	26.7	82	286	51	256	2.0e-26	112	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	258
649949714	303	39.93	21	293	1	248	9.0e-60	223	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
649949717	159	28.32	49	159	14	116	4.0e-06	44.2	COG2863	Cytochrome c553	121
649949719	614	23.04	8	609	10	606	6.0e-30	126	COG4206	Outer membrane cobalamin receptor protein	608
649949720	364	22.78	117	283	33	210	6.0e-08	52.2	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
649949721	343	15.45	104	310	33	249	6.0e-06	45.6	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
649949722	450	17.67	17	449	32	459	6.0e-20	92.7	COG0277	FAD/FMN-containing dehydrogenase	459
649949725	252	28.23	6	247	2	236	1.0e-29	123	COG0412	Dienelactone hydrolase	236
649949728	302	19.64	44	261	30	246	1.0e-11	64.5	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
649949729	817	55.27	1	692	3	691	0.0e+00	866	COG1185	Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)	692
649949730	88	59.09	1	88	2	89	3.0e-25	106	COG0184	Ribosomal protein S15P/S13E	89
649949731	226	33.61	1	226	1	235	4.0e-35	141	COG0412	Dienelactone hydrolase	236
649949733	300	23.19	10	271	11	271	1.0e-12	67.8	COG1344	Flagellin and related hook-associated protein FlgL	360
649949734	469	24.75	3	469	2	486	3.0e-30	126	COG1256	Flagellar hook-associated protein FlgK	552
649949736	97	27.85	27	93	10	88	2.0e-04	37.2	COG2747	Negative regulator of flagellin synthesis (anti-sigma28 factor)	93
649949738	398	49.56	58	398	23	365	2.0e-94	339	COG1706	Flagellar basal body P-ring protein FlgI	365
649949739	285	25.34	49	267	1	216	2.0e-24	106	COG2063	Flagellar basal body L-ring protein FlgH	230
649949741	262	50.94	1	262	1	265	2.0e-71	262	COG4786	Flagellar basal body rod protein FlgG	265
649949742	251	33.47	1	234	1	251	2.0e-37	149	COG4786	Flagellar basal body rod protein FlgG	265
649949745	432	39.55	1	430	2	425	6.0e-100	357	COG0128	5-enolpyruvylshikimate-3-phosphate synthase	428
649949746	172	45.39	13	163	4	151	2.0e-32	131	COG1259	Bifunctional DNase/RNase	151
649949747	440	43.05	1	436	1	435	0.0e+00	467	COG0621	tRNA A37 methylthiotransferase MiaB	437
649949749	212	53.66	6	210	3	192	7.0e-62	230	COG0807	GTP cyclohydrolase II	193
649949751	290	43.34	4	288	9	300	3.0e-84	305	COG1732	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)	300
649949754	181	48.1	25	179	5	160	1.0e-57	215	COG0386	Glutathione peroxidase, house-cleaning role in reducing lipid peroxides	162
649949755	532	20.59	38	438	56	473	3.0e-26	113	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
649949756	100	28.87	1	96	1	96	7.0e-07	45.4	COG3668	Plasmid stabilization system protein ParE	98
649949757	88	41.18	1	68	5	72	2.0e-04	37.8	COG3609	Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain	89
649949758	284	32.58	1	258	9	273	2.0e-43	169	COG3315	O-Methyltransferase involved in polyketide biosynthesis	297
649949759	284	39.58	3	283	2	281	3.0e-66	245	COG0061	NAD kinase	281
649949760	259	47.41	1	251	1	238	9.0e-73	267	COG1189	Predicted rRNA methylase YqxC, contains S4 and FtsJ domains	245
649949761	179	34.46	8	178	1	176	5.0e-25	107	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649949763	460	25.08	103	426	1	281	3.0e-06	47.1	COG3391	DNA-binding beta-propeller fold protein YncE	381
649949764	283	33.05	50	283	10	244	2.0e-26	113	COG1836	Uncharacterized membrane protein	247
649949765	218	20.62	22	210	24	206	7.0e-13	67.5	COG1434	Uncharacterized SAM-binding protein YcdF, DUF218 family	223
649949766	214	42.18	3	212	1	208	2.0e-50	191	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
649949767	263	37.36	8	262	1	260	1.0e-52	199	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
649949768	445	56.09	11	445	4	436	0.0e+00	572	COG2256	Replication-associated recombination protein RarA (DNA-dependent ATPase)	436
649949769	698	31.02	290	695	153	566	5.0e-69	255	COG4232	Thiol:disulfide interchange protein	569
649949770	132	46.15	1	127	3	132	1.0e-35	141	COG1832	Predicted CoA-binding protein	140
649949772	375	61.76	124	361	1	238	3.0e-93	335	COG1186	Protein chain release factor B	239
649949773	527	29.29	1	522	1	510	2.0e-74	273	COG0815	Apolipoprotein N-acyltransferase	518
649949776	117	35.14	5	115	21	130	2.0e-16	77.7	COG1664	Cytoskeletal protein CcmA, bactofilin family	146
649949779	260	33.12	88	241	32	187	3.0e-21	95.7	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
649949780	662	40.74	1	648	3	581	0.0e+00	571	COG0322	Excinuclease UvrABC, nuclease subunit	581
649949781	313	45.31	1	308	1	292	3.0e-74	272	COG2321	Predicted metalloprotease	295
649949784	271	42.47	5	263	4	257	9.0e-68	250	COG0030	16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity)	259
649949786	172	54.14	5	161	2	153	1.0e-43	168	COG0817	Holliday junction resolvasome RuvABC endonuclease subunit	160
649949787	256	58.75	1	256	5	260	1.0e-95	342	COG2022	Thiamin biosynthesis thiazole synthase ThiGH, ThiG subunit	262
649949791	314	33.22	10	313	6	253	3.0e-19	89.7	COG1989	Prepilin signal peptidase PulO (type II secretory pathway) or related peptidase	254
649949792	135	45.45	9	129	7	121	6.0e-26	109	COG0838	NADH:ubiquinone oxidoreductase subunit 3 (chain A)	123
649949793	163	44.37	21	162	11	152	9.0e-38	149	COG0852	NADH:ubiquinone oxidoreductase 27 kD subunit (chain C)	176
649949794	421	58.96	37	421	14	398	0.0e+00	567	COG0649	NADH:ubiquinone oxidoreductase 49 kD subunit (chain D)	398
649949796	169	39.62	5	163	1	159	9.0e-47	179	COG1905	NADH:ubiquinone oxidoreductase 24 kD subunit (chain E)	160
649949797	442	51.33	12	426	12	424	0.0e+00	540	COG1894	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit (chain F)	424
649949798	797	31.52	4	659	6	745	2.0e-128	454	COG3383	Predicted molibdopterin-dependent oxidoreductase YjgC	978
649949799	352	52.29	1	350	1	329	2.0e-90	326	COG1005	NADH:ubiquinone oxidoreductase subunit 1 (chain H)	332
649949800	174	40.96	1	166	3	164	2.0e-16	79.1	COG0839	NADH:ubiquinone oxidoreductase subunit 6 (chain J)	166
649949801	101	57.14	3	100	2	99	2.0e-20	90.1	COG0713	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)	100
649949802	664	43.95	6	656	1	606	9.0e-125	441	COG1009	NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit	606
649949803	544	45.64	6	495	4	482	9.0e-107	381	COG1008	NADH:ubiquinone oxidoreductase subunit 4 (chain M)	497
649949804	515	41.19	2	489	2	475	2.0e-90	326	COG1007	NADH:ubiquinone oxidoreductase subunit 2 (chain N)	475
649949805	234	28.57	15	224	3	211	1.0e-27	116	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649949807	104	42.42	36	101	8	73	2.0e-05	41	COG0636	FoF1-type ATP synthase, membrane subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K	79
649949808	243	35.94	38	242	32	246	3.0e-30	125	COG0356	FoF1-type ATP synthase, membrane subunit a	246
649949811	624	47.78	6	610	9	502	0.0e+00	596	COG1190	Lysyl-tRNA synthetase (class II)	502
649949813	268	54.28	1	268	1	259	1.0e-87	316	COG1692	Calcineurin-like phosphoesterase	266
649949815	124	27.82	1	120	1	133	6.0e-14	69.6	COG1959	DNA-binding transcriptional regulator, IscR family	150
649949817	1321	29.6	191	1303	89	1156	0.0e+00	473	COG1196	Chromosome segregation ATPase	1163
649949819	243	36.95	3	239	2	249	2.0e-43	169	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649949820	302	35.07	14	298	4	247	5.0e-63	234	COG0152	Phosphoribosylaminoimidazole-succinocarboxamide synthase	247
649949821	192	30	10	167	2	161	4.0e-17	81.4	COG1286	Uncharacterized membrane protein, required for colicin V production	182
649949824	606	34.75	36	570	16	546	5.0e-102	365	COG3882	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis	574
649949825	426	28.64	1	419	3	419	4.0e-60	225	COG3875	Nickel-dependent lactate racemase	423
649949826	219	24.88	10	214	6	214	8.0e-31	127	COG4845	Chloramphenicol O-acetyltransferase	219
649949829	194	52.91	1	185	1	189	3.0e-58	217	COG2156	K+-transporting ATPase, c chain	190
649949830	679	73.68	4	679	2	681	0.0e+00	1039	COG2216	High-affinity K+ transport system, ATPase chain B	681
649949831	595	59.04	5	589	4	560	0.0e+00	707	COG2060	K+-transporting ATPase, A chain	560
649949833	238	38.6	11	235	3	229	8.0e-51	193	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649949836	762	19.91	300	510	2	217	4.0e-12	67.1	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649949841	846	21.02	491	792	33	320	7.0e-03	36.9	COG3299	Uncharacterized phage protein gp47/JayE	353
649949850	625	22.09	153	607	1	482	1.0e-26	115	COG0464	AAA+-type ATPase, SpoVK/Ycf46/Vps4 family	494
649949854	468	34.97	1	465	3	461	3.0e-87	315	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
649949856	381	48.07	1	381	2	390	9.0e-105	373	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
649949857	391	30.39	14	391	5	371	4.0e-43	169	COG4299	Predicted acyltransferase	371
649949858	250	23.61	37	249	32	244	2.0e-07	50.1	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
649949859	338	28.93	3	196	7	203	8.0e-30	124	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
649949860	330	24.74	46	310	2	279	3.0e-20	93.2	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649949861	215	32.11	8	190	5	186	2.0e-25	109	COG0778	Nitroreductase	207
649949865	191	36.09	2	134	1	131	3.0e-26	111	COG0231	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)	131
649949867	1103	53.84	24	1037	6	935	0.0e+00	1311	COG0178	Excinuclease UvrABC ATPase subunit	935
649949871	60	40	5	59	2	56	3.0e-06	43.3	COG3847	Flp pilus assembly protein, pilin Flp	58
649949873	734	28.16	125	702	12	527	7.0e-76	279	COG2936	Predicted acyl esterase	563
649949874	91	38.98	26	82	2	60	2.0e-08	51.2	COG3369	Uncharacterized protein, contains Zn-finger domain of CDGSH type	78
649949877	487	43.48	20	479	6	457	1.0e-116	413	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
649949878	245	53.31	1	241	3	229	2.0e-67	248	COG0689	Ribonuclease PH	230
649949880	754	24.29	309	552	23	265	2.0e-10	61.8	COG3291	PKD repeat	297
649949884	614	28.43	219	404	48	243	6.0e-20	93	COG1651	Protein-disulfide isomerase	244
649949885	232	25.71	6	208	5	214	1.0e-17	83.4	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649949890	201	35.98	36	199	20	177	1.0e-25	109	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649949891	205	53.68	17	205	26	214	6.0e-66	243	COG0259	Pyridoxine/pyridoxamine 5'-phosphate oxidase	214
649949895	343	27.52	6	328	3	303	7.0e-29	121	COG3547	Transposase	303
649949898	186	26.37	1	179	1	165	7.0e-17	80.4	COG2258	Uncharacterized conserved protein YiiM, contains MOSC domain	210
649949899	149	24.44	10	133	13	136	3.0e-09	54.9	COG1943	REP element-mobilizing transposase RayT	136
649949901	678	31.43	113	627	5	496	3.0e-65	243	COG5267	Uncharacterized conserved protein, DUF1800 family	496
649949902	114	28.07	1	110	1	105	1.0e-09	55.3	COG3254	L-rhamnose mutarotase	105
649949905	381	24.91	99	350	26	278	8.0e-14	71.8	COG4974	Site-specific recombinase XerD	300
649949907	320	27.67	6	302	1	291	2.0e-20	93.9	COG0583	DNA-binding transcriptional regulator, LysR family	297
649949910	806	46.25	85	803	12	709	0.0e+00	723	COG2217	Cation transport ATPase	713
649949912	814	67.3	28	812	12	793	0.0e+00	1192	COG3957	Phosphoketolase	793
649949913	364	47.13	11	340	5	332	1.0e-102	366	COG3588	Fructose-bisphosphate aldolase class 1	332
649949914	266	48	6	254	2	246	2.0e-73	269	COG0149	Triosephosphate isomerase	251
649949915	846	30.36	26	781	5	742	0.0e+00	522	COG0058	Glucan phosphorylase	750
649949916	561	56.76	25	549	1	524	0.0e+00	632	COG0033	Phosphoglucomutase	524
649949917	289	35.11	6	267	21	269	2.0e-64	239	COG2326	Polyphosphate kinase 2, PPK2 family	270
649949918	310	22.74	6	292	1	286	2.0e-41	163	COG0224	FoF1-type ATP synthase, gamma subunit	287
649949919	521	53.91	24	509	17	502	0.0e+00	654	COG0056	FoF1-type ATP synthase, alpha subunit	504
649949920	262	24.53	1	159	2	160	6.0e-12	64.9	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	161
649949921	94	37.18	4	81	2	79	6.0e-08	49.1	COG0636	FoF1-type ATP synthase, membrane subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K	79
649949922	238	28.21	1	218	10	243	4.0e-33	134	COG0356	FoF1-type ATP synthase, membrane subunit a	246
649949925	130	25.2	1	126	4	129	2.0e-11	61.1	COG0355	FoF1-type ATP synthase, epsilon subunit	135
649949926	490	50.11	11	469	4	468	0.0e+00	625	COG0055	FoF1-type ATP synthase, beta subunit	468
649949927	321	24.7	66	309	2	220	6.0e-17	82.1	COG3039	Transposase and inactivated derivatives, IS5 family	230
649949929	697	47.59	15	694	14	691	0.0e+00	681	COG1523	Pullulanase/glycogen debranching enzyme	697
649949930	330	35.1	1	330	4	337	3.0e-73	268	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
649949932	257	29.7	14	213	9	209	3.0e-25	109	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649949934	147	39.2	25	146	23	142	4.0e-20	90.9	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
649949935	401	28.14	145	400	77	328	3.0e-31	129	COG0642	Signal transduction histidine kinase	336
649949936	501	33.76	246	469	1	232	4.0e-29	123	COG0467	RecA-superfamily ATPase, KaiC/GvpD/RAD55 family	260
649949939	568	36.61	10	190	7	186	6.0e-21	96.1	COG1475	Chromosome segregation protein Spo0J, contains ParB-like nuclease domain	240
649949941	411	29.62	25	351	4	284	4.0e-26	112	COG4974	Site-specific recombinase XerD	300
649949942	387	28.68	9	136	7	127	2.0e-06	47.2	COG3415	Transposase	138
649949943	134	41.67	5	111	1	108	7.0e-20	89.4	COG0789	DNA-binding transcriptional regulator, MerR family	124
649949946	217	28.26	25	206	27	209	2.0e-24	106	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649949947	92	56.25	6	68	4	67	8.0e-20	88.7	COG1278	Cold shock protein, CspA family	67
649949951	810	33.87	3	126	9	131	2.0e-21	98.5	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	148
649949952	278	29.91	150	255	10	116	3.0e-09	56	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
649949954	268	22.95	136	257	1	122	5.0e-10	58.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
649949957	540	31.39	24	532	1	535	2.0e-73	270	COG1574	Predicted amidohydrolase YtcJ	535
649949958	488	29.12	18	332	1	327	1.0e-32	134	COG3344	Retron-type reverse transcriptase	328
649949968	292	33.51	106	290	1	177	7.0e-27	114	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649949971	304	29.32	1	304	8	329	5.0e-41	161	COG0506	Proline dehydrogenase	391
649949973	273	24.19	2	249	1	240	2.0e-22	99.4	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649949974	353	38.17	54	306	19	274	3.0e-51	195	COG0616	Periplasmic serine protease, ClpP class	317
649949975	108	46.74	1	92	2	93	1.0e-28	118	COG0776	Bacterial nucleoid DNA-binding protein	94
649949976	265	34.96	1	264	1	266	4.0e-65	241	COG1131	ABC-type multidrug transport system, ATPase component	293
649949978	264	37.25	11	261	8	247	5.0e-52	197	COG1496	Copper oxidase (laccase) domain	249
649949979	571	38.6	240	512	2	281	3.0e-66	246	COG0169	Shikimate 5-dehydrogenase	283
649949980	875	47.09	257	874	134	730	0.0e+00	623	COG1198	Primosomal protein N' (replication factor Y) - superfamily II helicase	730
649949981	93	48.24	5	89	2	86	4.0e-21	92.9	COG0776	Bacterial nucleoid DNA-binding protein	94
649949982	184	38.5	3	184	2	181	8.0e-55	206	COG0717	Deoxycytidine triphosphate deaminase	183
649949983	214	32.21	12	213	2	208	5.0e-25	107	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649949984	234	38.34	32	220	24	216	4.0e-35	141	COG2930	Lipid-binding SYLF domain	227
649949985	313	37.16	19	313	20	307	6.0e-60	224	COG1560	Lauroyl/myristoyl acyltransferase	308
649949986	319	40.13	35	318	23	323	2.0e-62	232	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	338
649949987	247	30.53	1	216	2	225	3.0e-25	109	COG2120	N-acetylglucosaminyl deacetylase, LmbE family	237
649949989	637	36.58	26	310	20	311	2.0e-65	244	COG0646	Methionine synthase I (cobalamin-dependent), methyltransferase domain	311
649949990	88	40.58	1	69	9	77	7.0e-07	45.7	COG1722	Exonuclease VII small subunit	81
649949992	194	36.22	3	186	1	183	2.0e-35	142	COG4185	Predicted ABC-type ATPase	187
649949993	329	36.84	13	328	4	321	6.0e-68	251	COG0142	Geranylgeranyl pyrophosphate synthase	322
649949994	166	52.44	1	164	1	164	3.0e-41	161	COG1666	Uncharacterized conserved protein YajQ, UPF0234 family	165
649949995	281	44.32	7	275	2	254	5.0e-75	274	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
649949997	290	42	99	285	2	200	7.0e-40	157	COG1573	Uracil-DNA glycosylase	202
649949998	73	36.92	1	60	4	68	4.0e-05	39.5	COG1758	DNA-directed RNA polymerase, subunit K/omega	74
649949999	220	54.3	3	188	4	184	4.0e-58	218	COG0194	Guanylate kinase	191
649950000	298	35.69	3	298	1	290	1.0e-55	210	COG1561	Uncharacterized conserved protein YicC, UPF0701 family	290
649950001	595	42.39	61	578	54	567	1.0e-124	440	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
649950003	317	51.4	36	317	2	285	2.0e-95	342	COG1660	RNase adaptor protein for sRNA GlmZ degradation, contains a P-loop ATPase domain	286
649950004	217	32.04	7	199	1	206	9.0e-23	100	COG0778	Nitroreductase	207
649950005	693	41	1	691	3	691	0.0e+00	622	COG0751	Glycyl-tRNA synthetase, beta subunit	691
649950007	324	56.67	16	315	5	288	3.0e-116	411	COG0752	Glycyl-tRNA synthetase, alpha subunit	298
649950010	248	26.14	12	248	9	241	5.0e-23	101	COG1381	Recombinational DNA repair protein (RecF pathway)	251
649950012	422	39.39	1	96	1	98	3.0e-11	63.4	COG4104	Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, incolved in TypeVI secretion	98
649950014	291	48.45	9	260	7	255	1.0e-61	230	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
649950015	111	38.74	1	109	3	110	4.0e-14	70	COG2337	mRNA-degrading endonuclease, toxin component of the MazEF toxin-antitoxin module	112
649950016	84	25.93	4	84	3	81	2.0e-05	41.1	COG2336	Antitoxin component of the MazEF toxin-antitoxin module	82
649950018	147	43.48	1	137	4	141	3.0e-36	144	COG0314	Molybdopterin synthase catalytic subunit	149
649950019	112	39.29	26	108	2	84	2.0e-13	67.7	COG1977	Molybdopterin converting factor, small subunit	84
649950021	816	53.31	30	797	10	776	0.0e+00	984	COG0466	ATP-dependent Lon protease, bacterial type	782
649950022	288	38.49	15	288	4	275	6.0e-68	251	COG0077	Prephenate dehydratase	279
649950024	105	40	1	55	3	57	6.0e-06	42.6	COG3237	Uncharacterized conserved protein YjbJ, UPF0337 family	67
649950025	288	34.38	1	285	3	289	2.0e-34	140	COG0382	4-hydroxybenzoate polyprenyltransferase	289
649950028	1061	22.87	306	1061	89	766	1.0e-60	228	COG4775	Outer membrane protein assembly factor BamA	766
649950030	351	41.41	10	257	10	254	2.0e-58	220	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
649950031	213	39.66	20	198	2	177	3.0e-33	134	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649950033	537	25.1	58	522	54	522	9.0e-52	198	COG4365	Uncharacterized protein YllA, UPF0747 family	537
649950034	211	33.33	85	207	19	154	4.0e-09	55	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
649950035	584	37.13	1	332	3	326	8.0e-70	258	COG1796	DNA polymerase/3'-5' exonuclease PolX	326
649950037	887	15.62	83	751	18	723	5.0e-07	50.7	COG1629	Outer membrane receptor proteins, mostly Fe transport	768
649950040	319	37.12	21	318	18	302	2.0e-52	200	COG0109	Polyprenyltransferase (heme O synthase)	304
649950041	185	35.33	18	184	11	176	1.0e-23	103	COG2322	Uncharacterized membrane protein YozB, DUF420 family	177
649950043	163	33.13	4	163	2	167	2.0e-29	121	COG0629	Single-stranded DNA-binding protein	167
649950044	275	41.28	49	268	22	256	1.0e-53	203	COG3258	Cytochrome c	293
649950045	127	28.21	13	125	4	120	4.0e-11	60.3	COG4272	Uncharacterized membrane protein	125
649950046	279	29.71	1	275	1	255	3.0e-14	72.4	COG0730	Uncharacterized membrane protein YfcA	258
649950047	161	40.74	52	158	6	111	2.0e-20	92.2	COG1416	Intracellular sulfur oxidation protein, DsrE/DsrF family	112
649950049	480	37.69	22	474	3	454	2.0e-110	393	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
649950050	111	23.81	2	106	1	102	1.0e-08	51.8	COG1965	Iron-binding protein CyaY, frataxin homolog	106
649950051	263	22.26	1	263	2	270	1.0e-16	80.6	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649950055	148	39.39	10	140	9	137	4.0e-27	113	COG0824	Acyl-CoA thioesterase FadM	137
649950056	204	26.8	13	204	9	198	3.0e-07	48.9	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649950064	394	25.81	11	379	2	333	3.0e-30	126	COG1466	DNA polymerase III, delta subunit	334
649950065	168	25.47	2	161	6	154	9.0e-06	43.4	COG2980	Outer membrane lipoprotein LptE/RlpB (LPS assembly)	178
649950066	639	56.15	9	602	1	595	0.0e+00	711	COG0465	ATP-dependent Zn proteases	596
649950067	351	38.49	11	247	20	251	4.0e-41	162	COG0037	tRNA(Ile)-lysidine synthase TilS/MesJ	298
649950069	322	23.3	22	120	19	116	5.0e-06	45.4	COG3677	Transposase	129
649950072	545	59.2	23	544	1	521	0.0e+00	680	COG0033	Phosphoglucomutase	524
649950073	392	46.99	213	377	12	176	7.0e-38	151	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
649950074	572	19.84	58	423	43	391	7.0e-10	59.4	COG2814	Predicted arabinose efflux permease, MFS family	394
649950075	617	59.23	20	617	14	606	0.0e+00	825	COG1274	Phosphoenolpyruvate carboxykinase, GTP-dependent	608
649950076	512	17.06	279	475	10	206	1.0e-08	55.3	COG2755	Lysophospholipase L1 or related esterase	216
649950078	465	20.78	8	465	7	450	2.0e-16	81	COG0531	Amino acid transporter	466
649950080	530	58.13	20	339	11	330	1.0e-103	370	COG0206	Cell division GTPase FtsZ	338
649950081	389	35.97	10	389	3	371	2.0e-62	233	COG4299	Predicted acyltransferase	371
649950082	185	32.04	8	185	1	181	2.0e-19	89	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649950086	411	39.19	6	411	5	418	2.0e-92	333	COG0849	Cell division ATPase FtsA	418
649950087	435	20.71	68	346	10	269	2.0e-19	90.5	COG1589	Cell division septal protein FtsQ	269
649950088	463	53.15	7	463	2	458	0.0e+00	551	COG0773	UDP-N-acetylmuramate-alanine ligase	459
649950090	227	24.64	27	227	27	233	4.0e-12	65.3	COG0670	Integral membrane protein, interacts with FtsH	233
649950092	353	35.6	29	349	1	298	9.0e-63	234	COG2421	Acetamidase/formamidase	305
649950094	359	39.29	1	356	1	357	4.0e-75	275	COG0707	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase	357
649950095	363	39.29	3	361	10	371	3.0e-72	265	COG0772	Bacterial cell division protein FtsW, lipid II flippase	381
649950096	451	43.9	3	450	5	446	5.0e-123	434	COG0771	UDP-N-acetylmuramoylalanine-D-glutamate ligase	448
649950098	451	40.29	23	434	9	413	8.0e-90	324	COG0738	Fucose permease	422
649950100	378	39.5	28	378	6	316	7.0e-52	198	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
649950101	456	40.74	1	455	1	448	1.0e-101	363	COG0770	UDP-N-acetylmuramyl pentapeptide synthase	451
649950102	489	42.19	20	488	8	475	4.0e-108	385	COG0769	UDP-N-acetylmuramyl tripeptide synthase	475
649950103	781	35.68	7	597	1	599	5.0e-118	419	COG0768	Cell division protein FtsI/penicillin-binding protein 2	599
649950105	297	50.47	1	296	2	311	1.0e-98	353	COG0275	16S rRNA C1402 N4-methylase RsmH	314
649950106	144	34.93	1	141	1	139	3.0e-19	87.6	COG2001	MraZ, DNA-binding transcriptional regulator and inhibitor of RsmH methyltransferase activity	146
649950107	183	26.03	31	176	7	148	1.0e-10	60	COG3305	Uncharacterized membrane protein, DUF2068 family	152
649950108	188	48.89	8	187	15	181	5.0e-39	153	COG2335	Uncaracterized surface protein containing fasciclin (FAS1) repeats	187
649950111	228	53.28	1	228	3	229	8.0e-77	279	COG3128	Predicted 2-oxoglutarate- and Fe(II)-dependent dioxygenase YbiX	229
649950112	871	32.39	114	871	50	750	1.0e-123	438	COG4774	Outer membrane receptor for monomeric catechols	750
649950113	186	28.81	4	176	3	152	1.0e-15	76.7	COG4276	Ligand-binding SRPBCC domain	153
649950114	143	46.43	4	142	2	140	2.0e-33	135	COG0816	RNase H-fold protein, predicted Holliday junction resolvase in Firmicutes and mycoplasms, involved in anti-termination at Rho-dependent terminators	141
649950116	492	36.44	7	479	22	524	1.0e-87	317	COG0659	Sulfate permease or related transporter, MFS superfamily	554
649950118	93	41.11	4	91	1	90	2.0e-17	81.1	COG2929	Uncharacterized conserved protein, DUF497 family	93
649950120	629	51.13	4	620	4	624	0.0e+00	778	COG1154	Deoxyxylulose-5-phosphate synthase	627
649950121	463	45.54	54	453	6	406	2.0e-83	303	COG1301	Na+/H+-dicarboxylate symporter	415
649950123	1119	26.79	27	679	40	644	3.0e-51	197	COG4946	Uncharacterized N-terminal domain of tricorn protease	668
649950124	193	25.2	64	184	14	136	2.0e-06	45.7	COG4319	Ketosteroid isomerase homolog	137
649950125	797	32.98	419	789	94	447	2.0e-56	214	COG5002	Signal transduction histidine kinase	459
649950126	662	47.69	86	647	1	528	0.0e+00	669	COG0365	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase	528
649950127	403	20.26	24	391	31	396	8.0e-12	65.2	COG2223	Nitrate/nitrite transporter NarK	417
649950130	193	33.95	10	171	2	162	9.0e-24	103	COG2323	Uncharacterized membrane protein YcaP, DUF421 family	224
649950131	322	53.37	1	322	1	326	0.0e+00	467	COG1087	UDP-glucose 4-epimerase	329
649950136	198	20.33	1	171	1	180	4.0e-03	34.9	COG3047	Outer membrane protein W	213
649950138	304	32.56	1	298	1	297	3.0e-32	132	COG0583	DNA-binding transcriptional regulator, LysR family	297
649950139	393	50	8	385	1	376	3.0e-112	398	COG0119	Isopropylmalate/homocitrate/citramalate synthases	409
649950140	369	48.49	1	359	2	348	5.0e-107	381	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
649950143	497	51.73	7	493	1	422	0.0e+00	614	COG0065	Homoaconitase/3-isopropylmalate dehydratase large subunit	423
649950144	213	50.25	1	203	1	191	1.0e-65	242	COG0066	3-isopropylmalate dehydratase small subunit	191
649950146	564	50	7	563	9	570	0.0e+00	651	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
649950147	599	48.09	8	583	1	549	0.0e+00	593	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
649950148	195	29.14	10	181	4	177	4.0e-23	101	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
649950150	213	40.48	1	168	3	162	1.0e-32	133	COG0440	Acetolactate synthase, small subunit	163
649950151	341	61.19	1	335	2	336	0.0e+00	490	COG0059	Ketol-acid reductoisomerase	338
649950153	94	47.31	1	88	27	119	9.0e-25	105	COG2343	Uncharacterized conserved protein, DUF427 family	132
649950154	933	42.28	783	898	18	140	5.0e-20	93.7	COG0551	ssDNA-binding Zn-finger and Zn-ribbon domains of topoisomerase 1	140
649950154	933	48.29	3	607	1	570	0.0e+00	625	COG0550	DNA topoisomerase IA	570
649950155	404	37.63	16	403	6	350	2.0e-84	306	COG0758	Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake	350
649950156	279	27.44	8	272	9	251	3.0e-28	119	COG1427	Predicted periplasmic solute-binding protein	252
649950157	234	26.4	32	220	14	208	5.0e-08	51.4	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
649950158	338	52.92	12	336	3	322	2.0e-102	366	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
649950161	128	28.07	1	114	11	111	4.0e-13	67.2	COG2151	Metal-sulfur cluster biosynthetic enzyme	111
649950163	510	44.44	25	505	1	472	0.0e+00	506	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
649950164	124	61.4	1	114	1	114	2.0e-44	171	COG3564	Uncharacterized conserved protein, DUF779 family	116
649950167	149	41.73	8	146	1	136	2.0e-31	128	COG0802	tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE	149
649950168	540	42.16	1	201	2	193	6.0e-40	159	COG0062	NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain	203
649950168	540	45.45	241	515	21	282	4.0e-59	222	COG0063	NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain	284
649950169	840	45.75	6	840	53	906	0.0e+00	918	COG0567	2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes	906
649950171	66	56.72	1	66	1	67	4.0e-21	92.9	COG1278	Cold shock protein, CspA family	67
649950172	241	47.58	10	235	1	221	1.0e-61	229	COG0283	Cytidylate kinase	222
649950174	659	38.72	1	659	1	638	0.0e+00	552	COG0323	DNA mismatch repair ATPase MutL	638
649950175	164	28.66	14	159	31	186	3.0e-07	48.3	COG4636	Endonuclease, Uma2 family (restriction endonuclease fold)	200
649950176	482	49.9	1	474	1	477	0.0e+00	525	COG0469	Pyruvate kinase	477
649950177	305	26.76	6	303	4	299	5.0e-24	105	COG1295	Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase)	303
649950180	314	25.56	63	279	67	287	4.0e-20	92.3	COG0657	Acetyl esterase/lipase	312
649950183	222	27.67	10	213	9	213	2.0e-21	96.1	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649950187	145	21.05	1	143	12	163	4.0e-06	44.3	COG4961	Flp pilus assembly protein TadG	185
649950188	205	51.2	81	204	4	128	3.0e-52	198	COG0229	Peptide methionine sulfoxide reductase MsrB	140
649950195	549	23.08	30	183	12	152	3.0e-05	43.7	COG5616	TolB amino-terminal domain (function unknown)	152
649950196	439	35.43	7	428	7	429	1.0e-76	281	COG1030	Membrane-bound serine protease (ClpP class)	436
649950198	265	41.9	1	204	2	211	1.0e-34	140	COG0330	Regulator of protease activity HflC, stomatin/prohibitin superfamily	291
649950200	238	28.07	8	230	6	227	2.0e-27	115	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
649950201	478	39.04	1	477	1	458	2.0e-114	406	COG0773	UDP-N-acetylmuramate-alanine ligase	459
649950202	304	39.8	1	290	1	301	4.0e-68	251	COG1619	Muramoyltetrapeptide carboxypeptidase LdcA (peptidoglycan recycling)	313
649950203	266	36.2	2	265	1	271	9.0e-52	197	COG0253	Diaminopimelate epimerase	272
649950204	233	31.07	23	226	13	216	2.0e-30	125	COG1285	Uncharacterized membrane protein YhiD, involved in acid resistance	221
649950206	314	25	2	301	1	308	4.0e-17	82.5	COG0524	Sugar or nucleoside kinase, ribokinase family	311
649950207	286	44.8	3	247	16	262	6.0e-71	260	COG0005	Purine nucleoside phosphorylase	262
649950209	324	22.32	1	323	5	300	6.0e-37	148	COG0354	Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification	305
649950212	266	29.28	2	253	7	259	2.0e-35	142	COG1235	Phosphoribosyl 1,2-cyclic phosphodiesterase	269
649950213	324	35.05	1	311	1	304	1.0e-67	250	COG0196	FAD synthase	304
649950214	419	32.52	9	367	2	366	8.0e-45	174	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	406
649950215	192	32.85	1	133	2	137	3.0e-13	68.5	COG1896	5'-deoxynucleotidase YfbR and related HD superfamily hydrolases	193
649950217	240	43.9	1	240	1	245	6.0e-69	254	COG1212	CMP-2-keto-3-deoxyoctulosonic acid synthetase	247
649950218	224	33.65	8	208	2	209	1.0e-31	129	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
649950219	477	33.12	1	472	5	457	3.0e-94	339	COG1109	Phosphomannomutase	464
649950220	380	39.08	10	354	1	331	1.0e-97	350	COG0836	Mannose-1-phosphate guanylyltransferase	333
649950221	398	41.6	12	398	1	393	3.0e-103	368	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
649950224	408	33.08	144	404	102	363	2.0e-47	183	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
649950228	169	52.26	10	164	4	157	4.0e-57	213	COG0669	Phosphopantetheine adenylyltransferase	159
649950229	198	34.52	22	189	16	174	4.0e-21	94.8	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649950232	357	62.11	1	282	3	279	4.0e-83	301	COG0468	RecA/RadA recombinase	279
649950233	491	23.72	45	248	55	265	2.0e-07	51.2	COG1351	Thymidylate synthase ThyX	273
649950234	249	38.66	7	240	11	232	2.0e-40	159	COG3361	Uncharacterized protein YqjF, DUF2071 family	240
649950235	175	30.67	4	163	8	167	5.0e-13	67.8	COG3652	Predicted outer membrane protein	170
649950236	248	55.56	3	245	2	250	5.0e-46	178	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649950239	292	49.28	8	283	2	271	2.0e-84	305	COG0313	16S rRNA C1402 (ribose-2'-O) methylase RsmI	275
649950240	391	24.9	4	254	3	230	2.0e-10	60.4	COG1994	Zn-dependent protease (includes SpoIVFB)	230
649950241	203	39.27	1	190	2	187	9.0e-37	146	COG0742	16S rRNA G966 N2-methylase RsmD	187
649950243	370	38.54	1	370	6	396	1.0e-89	323	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
649950245	298	39.75	11	295	7	317	1.0e-64	239	COG0611	Thiamine monophosphate kinase	317
649950246	343	29.72	82	329	16	262	5.0e-30	125	COG0739	Murein DD-endopeptidase MepM and murein hydrolase activator NlpD, contain LysM domain	277
649950248	318	43.93	13	311	4	299	2.0e-81	296	COG0031	Cysteine synthase	300
649950249	149	24.77	1	109	1	102	2.0e-12	65.2	COG1310	Proteasome lid subunit RPN8/RPN11, contains Jab1/MPN domain metalloenzyme (JAMM) motif	134
649950250	97	23.33	1	90	2	84	2.0e-04	37.6	COG1977	Molybdopterin converting factor, small subunit	84
649950251	405	56.69	12	260	1	254	8.0e-74	271	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
649950253	431	40.48	8	324	5	331	3.0e-72	266	COG0460	Homoserine dehydrogenase	333
649950254	160	41.18	6	123	7	124	4.0e-35	140	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
649950255	450	38.37	10	439	10	427	8.0e-99	354	COG0044	Dihydroorotase or related cyclic amidohydrolase	430
649950256	175	28.57	32	169	30	168	2.0e-11	62.2	COG3195	2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) decarboxylase	176
649950257	112	45.61	3	112	11	124	8.0e-32	128	COG2351	5-hydroxyisourate hydrolase (purine catabolism), transthyretin-related family	124
649950258	287	33.92	14	287	13	298	1.0e-54	207	COG3648	Uricase (urate oxidase)	299
649950259	408	24.12	28	398	27	406	1.0e-25	111	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
649950260	248	34.65	1	245	11	264	4.0e-56	211	COG3257	Uncharacterized protein, possibly involved in glyoxylate utilization	264
649950261	423	21.16	36	423	28	409	1.0e-24	107	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
649950262	555	40.31	3	453	16	467	6.0e-117	415	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
649950265	1087	23.27	707	1086	23	394	1.0e-28	122	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	406
649950266	582	29.74	3	552	39	606	1.0e-122	433	COG0296	1,4-alpha-glucan branching enzyme	628
649950267	893	41.33	4	885	3	889	0.0e+00	789	COG3280	Maltooligosyltrehalose synthase	889
649950268	616	31.07	15	603	14	605	1.0e-104	374	COG3387	Glucoamylase (glucan-1,4-alpha-glucosidase), GH15 family	612
649950270	1210	33.76	16	524	1	505	4.0e-87	316	COG0366	Glycosidase	505
649950273	84	28.75	1	80	1	80	9.0e-08	48.8	COG0236	Acyl carrier protein	80
649950275	193	36.92	1	188	3	197	9.0e-31	126	COG2068	CTP:molybdopterin cytidylyltransferase MocA	199
649950276	366	27.08	4	339	4	266	3.0e-25	109	COG1975	Xanthine and CO dehydrogenase maturation factor, XdhC/CoxF family	278
649950280	291	22.08	4	280	1	303	2.0e-21	96.7	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
649950281	262	29.46	1	257	23	274	3.0e-28	118	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
649950282	550	24.09	1	537	4	555	2.0e-55	210	COG0747	ABC-type transport system, periplasmic component	556
649950283	326	41.7	5	261	7	265	9.0e-70	257	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
649950284	638	24.07	37	566	18	501	8.0e-11	62.7	COG1404	Serine protease, subtilisin family	508
649950285	453	48.85	270	441	3	175	2.0e-43	170	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
649950287	407	27.45	38	388	1	356	3.0e-60	225	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
649950288	164	35.43	38	164	20	130	4.0e-16	77.6	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
649950289	542	28.8	45	540	2	450	5.0e-61	229	COG1231	Monoamine oxidase	450
649950291	99	34.02	1	97	1	93	7.0e-10	55.6	COG1550	Uncharacterized conserved protein YlxP, DUF503 family	95
649950292	142	34.75	5	121	1	118	1.0e-17	82.5	COG0858	Ribosome-binding factor A	118
649950293	650	25	45	571	10	490	6.0e-37	149	COG1807	4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of PMT family	535
649950295	163	28.21	47	163	42	146	6.0e-08	50.7	COG5652	VanZ like family protein (function unknown)	148
649950296	508	26.97	256	496	1	169	4.0e-30	126	COG0516	IMP dehydrogenase/GMP reductase	170
649950299	133	42.11	20	133	5	118	8.0e-27	112	COG1733	DNA-binding transcriptional regulator, HxlR family	120
649950300	283	36.82	1	269	2	275	1.0e-33	136	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
649950301	150	22.66	25	143	6	131	8.0e-10	56.5	COG5485	Predicted ester cyclase	131
649950302	391	24.13	7	361	6	358	2.0e-20	94.1	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649950303	207	30.2	5	206	7	152	3.0e-25	108	COG0779	Ribosome maturation factor RimP	153
649950304	534	46.43	159	354	1	190	6.0e-42	165	COG0195	Transcription antitermination factor NusA, contains S1 and KH domains	190
649950305	1082	54.71	542	1050	2	507	0.0e+00	629	COG0532	Translation initiation factor IF-2, a GTPase	509
649950307	70	48.44	5	67	3	65	1.0e-16	78.3	COG1278	Cold shock protein, CspA family	67
649950309	391	25.62	1	391	10	383	2.0e-37	150	COG0006	Xaa-Pro aminopeptidase	384
649950312	159	56.03	1	116	1	116	8.0e-39	153	COG0203	Ribosomal protein L17	116
649950314	367	47.02	6	324	1	315	4.0e-89	321	COG0202	DNA-directed RNA polymerase, alpha subunit/40 kD subunit	317
649950315	210	50.71	1	210	1	205	5.0e-54	204	COG0522	Ribosomal protein S4 or related protein	205
649950316	142	63.49	17	142	4	129	2.0e-42	164	COG0100	Ribosomal protein S11	129
649950317	126	62.3	1	122	1	121	7.0e-39	152	COG0099	Ribosomal protein S13	121
649950318	37	68.42	1	37	1	38	2.0e-03	34.4	COG0257	Ribosomal protein L36	38
649950319	72	68.06	1	72	1	72	5.0e-24	102	COG0361	Translation initiation factor IF-1	75
649950320	249	49.8	1	249	1	251	1.0e-86	312	COG0024	Methionine aminopeptidase	255
649950321	250	36.57	27	242	3	178	2.0e-40	159	COG0563	Adenylate kinase or related kinase	178
649950322	470	47.7	1	457	6	430	6.0e-111	394	COG0201	Preprotein translocase subunit SecY	436
649950323	161	51.32	6	153	3	152	1.0e-30	126	COG0200	Ribosomal protein L15	152
649950324	60	40	6	60	1	55	5.0e-08	49.3	COG1841	Ribosomal protein L30/L7E	55
649950325	168	56.63	4	168	14	178	2.0e-48	185	COG0098	Ribosomal protein S5	181
649950326	121	57.26	1	121	2	125	3.0e-32	130	COG0256	Ribosomal protein L18	125
649950327	179	46.93	1	177	1	177	8.0e-47	179	COG0097	Ribosomal protein L6P/L9E	178
649950328	132	49.24	1	132	1	132	9.0e-45	172	COG0096	Ribosomal protein S8	132
649950329	61	55.74	1	61	1	61	1.0e-14	71.8	COG0199	Ribosomal protein S14	61
649950330	195	59.55	15	192	1	178	4.0e-67	247	COG0094	Ribosomal protein L5	180
649950331	119	54.29	12	113	2	103	8.0e-14	69.2	COG0198	Ribosomal protein L24	104
649950332	123	61.16	3	123	2	122	3.0e-40	157	COG0093	Ribosomal protein L14	122
649950333	117	53.16	22	100	7	85	3.0e-21	93.4	COG0186	Ribosomal protein S17	87
649950334	90	40.62	4	67	6	69	6.0e-03	32.5	COG0255	Ribosomal protein L29	69
649950335	144	57.97	1	136	2	139	3.0e-46	177	COG0197	Ribosomal protein L16/L10AE	146
649950336	228	57.07	12	214	1	205	7.0e-70	257	COG0092	Ribosomal protein S3	233
649950337	168	41.18	7	125	7	120	2.0e-20	92.2	COG0091	Ribosomal protein L22	120
649950338	94	62.79	1	86	1	86	8.0e-34	134	COG0185	Ribosomal protein S19	93
649950339	274	58.55	1	274	1	275	8.0e-105	373	COG0090	Ribosomal protein L2	275
649950340	97	50.57	4	89	1	87	6.0e-20	89.1	COG0089	Ribosomal protein L23	94
649950341	226	44.13	1	210	1	212	3.0e-48	185	COG0088	Ribosomal protein L4	214
649950342	242	46.3	3	216	1	214	7.0e-62	230	COG0087	Ribosomal protein L3	218
649950343	105	69.23	1	104	1	104	4.0e-38	149	COG0051	Ribosomal protein S10	104
649950344	395	76.71	1	395	1	394	0.0e+00	690	COG0050	Translation elongation factor EF-Tu, a GTPase	394
649950345	697	64.99	1	694	1	694	0.0e+00	971	COG0480	Translation elongation factor EF-G, a GTPase	697
649950346	156	57.43	2	149	1	148	3.0e-52	197	COG0049	Ribosomal protein S7	148
649950347	128	77.24	1	123	7	129	3.0e-47	180	COG0048	Ribosomal protein S12	129
649950349	680	27.38	43	677	7	617	1.0e-70	261	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
649950351	140	33.09	1	134	7	145	1.0e-26	112	COG0781	Transcription termination factor NusB	151
649950352	277	53.95	121	272	1	152	1.0e-46	179	COG0054	6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)	152
649950353	260	49.61	1	254	2	255	1.0e-57	216	COG1024	Enoyl-CoA hydratase/carnithine racemase	257
649950355	352	46.47	1	339	2	297	8.0e-93	334	COG1159	GTPase Era, involved in 16S rRNA processing	298
649950357	450	34.2	65	444	64	421	3.0e-60	226	COG1253	Hemolysin or related protein, contains CBS domains	429
649950358	155	36.99	1	139	2	147	5.0e-25	106	COG0319	ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme	153
649950359	345	53.92	15	316	29	334	4.0e-94	338	COG1702	Phosphate starvation-inducible protein PhoH, predicted ATPase	348
649950360	135	30.25	6	122	1	119	3.0e-15	74.5	COG3682	Predicted transcriptional regulator	123
649950361	451	25.47	23	331	16	320	9.0e-22	98.5	COG4219	Signal transducer regulating beta-lactamase production, contains  metallopeptidase domain	337
649950362	93	36.05	1	86	1	86	7.0e-09	52.2	COG0268	Ribosomal protein S20	88
649950364	681	37.65	32	681	6	654	0.0e+00	569	COG3590	Predicted metalloendopeptidase	654
649950365	313	26.16	6	303	3	292	4.0e-08	52.6	COG0697	Permease of the drug/metabolite transporter (DMT) superfamily	292
649950366	390	27.01	27	386	12	382	1.0e-26	114	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649950367	420	36.49	62	398	54	382	2.0e-60	226	COG0498	Threonine synthase	411
649950368	319	29.69	6	298	2	258	4.0e-38	152	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
649950369	254	25.77	2	251	17	276	6.0e-16	77.9	COG0741	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)	296
649950370	347	17.34	2	324	14	307	3.0e-03	36.2	COG0392	Uncharacterized membrane protein YbhN, UPF0104 family	322
649950371	169	53.21	1	156	1	156	2.0e-45	175	COG1327	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains	156
649950372	339	49.42	1	337	1	345	5.0e-117	414	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
649950374	372	37.23	5	351	3	334	7.0e-82	297	COG0136	Aspartate-semialdehyde dehydrogenase	334
649950375	485	38.95	19	468	2	445	5.0e-101	361	COG0527	Aspartokinase	447
649950376	228	32.21	1	226	3	265	3.0e-37	148	COG0289	Dihydrodipicolinate reductase	266
649950377	417	43.1	13	416	3	384	2.0e-104	373	COG2309	Leucyl aminopeptidase (aminopeptidase T)	385
649950378	307	46.98	1	295	3	299	4.0e-80	291	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
649950379	283	40	25	283	26	269	3.0e-42	165	COG2171	Tetrahydrodipicolinate N-succinyltransferase	271
649950380	554	46.39	4	552	7	555	0.0e+00	554	COG0595	mRNA degradation ribonuclease J1/J2	555
649950381	427	20	99	287	1	187	3.0e-07	50	COG0412	Dienelactone hydrolase	236
649950382	328	27.05	1	324	8	321	2.0e-32	133	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
649950384	324	44.71	1	323	1	323	1.0e-88	320	COG1171	Threonine dehydratase	347
649950388	174	28.33	33	151	7	126	1.0e-09	56.5	COG1846	DNA-binding transcriptional regulator, MarR family	126
649950389	252	49.37	16	252	3	241	4.0e-79	287	COG1054	Predicted sulfurtransferase	308
649950390	295	31.42	1	290	4	266	2.0e-33	136	COG1968	Undecaprenyl pyrophosphate phosphatase UppP	270
649950392	296	22.15	1	293	1	307	5.0e-24	105	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649950393	164	19.77	14	163	1	159	3.0e-07	48.1	COG2318	Uncharacterized damage-inducible protein DinB (forms a four-helix bundle)	172
649950394	324	29.39	1	313	3	308	9.0e-47	180	COG2378	Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains	311
649950395	120	42.11	8	119	10	123	2.0e-21	94.6	COG4270	Uncharacterized membrane protein	131
649950397	884	28.12	6	875	1	857	1.0e-129	457	COG1674	DNA segregation ATPase FtsK/SpoIIIE and related proteins	858
649950402	240	41.2	23	238	1	211	7.0e-49	187	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649950403	336	27.78	5	323	1	293	4.0e-32	132	COG0492	Thioredoxin reductase	305
649950404	179	22.22	1	139	1	152	2.0e-05	42.6	COG4636	Endonuclease, Uma2 family (restriction endonuclease fold)	200
649950406	442	18.82	4	430	11	435	2.0e-24	107	COG1524	Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily	450
649950408	313	40	1	309	3	293	1.0e-71	263	COG1131	ABC-type multidrug transport system, ATPase component	293
649950410	257	54.4	1	249	1	246	3.0e-80	291	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
649950411	531	35.67	356	518	20	190	3.0e-26	113	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
649950415	516	48.87	1	308	2	297	2.0e-102	366	COG1951	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain	297
649950417	224	33.5	1	195	12	192	5.0e-24	104	COG0558	Phosphatidylglycerophosphate synthase	192
649950419	441	50.49	31	440	2	411	0.0e+00	496	COG0334	Glutamate dehydrogenase/leucine dehydrogenase	411
649950420	495	48.95	25	495	1	460	0.0e+00	492	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
649950422	166	30.07	2	151	1	146	2.0e-13	68.8	COG2405	Predicted nucleic acid-binding protein, contains PIN domain	157
649950424	206	56.31	1	206	3	190	1.0e-77	282	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
649950426	185	30.77	1	129	2	131	2.0e-26	112	COG0231	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)	131
649950427	98	43.59	8	85	6	83	1.0e-16	78	COG1254	Acylphosphatase	92
649950428	179	51.74	10	179	8	179	2.0e-46	178	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	179
649950429	350	40.29	1	347	1	339	4.0e-103	368	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
649950430	412	35.6	45	412	1	345	6.0e-69	255	COG2706	6-phosphogluconolactonase, cycloisomerase 2 family	346
649950433	805	38.92	138	766	3	552	0.0e+00	509	COG1982	Arginine/lysine/ornithine decarboxylase	557
649950434	448	41.65	1	447	6	462	2.0e-94	339	COG1109	Phosphomannomutase	464
649950435	528	42.99	83	524	6	440	2.0e-113	403	COG1570	Exonuclease VII, large subunit	440
649950438	266	22.64	45	255	17	203	4.0e-04	39.1	COG2976	Putative negative regulator of RcsB-dependent stress response	207
649950439	170	50	4	148	2	147	9.0e-46	176	COG0102	Ribosomal protein L13	148
649950440	131	54.76	6	131	5	130	1.0e-39	155	COG0103	Ribosomal protein S9	130
649950441	313	59.83	1	239	1	238	3.0e-94	338	COG0052	Ribosomal protein S2	252
649950445	126	55.05	3	111	2	108	9.0e-36	142	COG0139	Phosphoribosyl-AMP cyclohydrolase	111
649950446	292	36.77	5	291	2	289	1.0e-59	223	COG0040	ATP phosphoribosyltransferase	290
649950447	426	47.96	19	422	10	421	1.0e-125	443	COG0141	Histidinol dehydrogenase	425
649950448	377	37.75	11	356	1	352	2.0e-68	252	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
649950449	199	53.09	6	199	4	195	9.0e-69	253	COG0131	Imidazoleglycerol phosphate dehydratase HisB	195
649950450	202	45.37	1	202	3	202	2.0e-63	235	COG0118	Imidazoleglycerol phosphate synthase glutamine amidotransferase subunit HisH	204
649950452	256	59.77	1	255	1	256	4.0e-96	344	COG0107	Imidazole glycerol phosphate synthase subunit HisF	256
649950453	234	31.25	1	230	3	227	5.0e-33	134	COG0106	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase	241
649950458	270	33.73	6	257	20	270	4.0e-67	248	COG2326	Polyphosphate kinase 2, PPK2 family	270
649950461	417	47.3	1	407	3	390	3.0e-128	451	COG0448	ADP-glucose pyrophosphorylase	393
649950466	167	35.77	16	138	12	132	4.0e-27	114	COG2343	Uncharacterized conserved protein, DUF427 family	132
649950468	381	44.33	8	381	5	379	1.0e-105	376	COG0404	Glycine cleavage system T protein (aminomethyltransferase)	379
649950469	132	51.15	1	129	3	131	1.0e-33	134	COG0509	Glycine cleavage system H protein (lipoate-binding)	131
649950470	452	43.36	1	440	10	444	4.0e-130	458	COG0403	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain	450
649950473	515	49.08	18	499	3	485	0.0e+00	621	COG1003	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain	496
649950479	514	44.04	21	514	4	488	0.0e+00	542	COG0397	Uncharacterized conserved protein YdiU, UPF0061 family	488
649950480	131	43.18	35	120	12	99	2.0e-18	84.6	COG3695	Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain	103
649950481	393	33.68	10	392	14	338	1.0e-54	207	COG1566	Multidrug resistance efflux pump	352
649950482	495	25.92	54	483	16	444	3.0e-30	126	COG1538	Outer membrane protein TolC	457
649950484	289	35.74	5	289	4	288	9.0e-32	130	COG0583	DNA-binding transcriptional regulator, LysR family	297
649950485	709	43.7	35	708	3	648	0.0e+00	617	COG1505	Prolyl oligopeptidase PreP, S9A serine peptidase family	648
649950486	209	34.25	111	183	2	74	2.0e-10	59.2	COG2442	Uncharacterized conserved protein, DUF433 family	79
649950496	562	36.36	7	191	4	187	5.0e-21	96.1	COG1475	Chromosome segregation protein Spo0J, contains ParB-like nuclease domain	240
649950500	359	28.16	5	346	3	306	4.0e-31	129	COG0039	Malate/lactate dehydrogenase	313
649950507	114	51.11	17	106	13	101	6.0e-27	112	COG1733	DNA-binding transcriptional regulator, HxlR family	120
649950508	539	32.14	39	538	1	429	2.0e-83	303	COG0281	Malic enzyme	432
649950509	490	62.66	26	483	4	461	0.0e+00	708	COG0114	Fumarate hydratase class II	462
649950512	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649950515	349	39.13	1	349	3	358	1.0e-81	296	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
649950518	176	25.77	28	123	26	118	3.0e-08	51.7	COG1917	Cupin domain protein related to quercetin dioxygenase	131
649950519	281	23.05	8	278	7	274	4.0e-16	78.7	COG1082	Sugar phosphate isomerase/epimerase	274
649950520	104	17.05	2	87	1	88	2.0e-03	34.6	COG1359	Quinol monooxygenase YgiN	100
649950522	303	29.89	19	264	1	242	2.0e-24	106	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649950523	209	44.08	7	209	1	211	3.0e-47	181	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649950525	249	37.1	84	207	4	127	7.0e-22	97.6	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
649950526	249	36.08	2	247	1	251	2.0e-43	169	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649950527	125	21.3	17	120	20	127	5.0e-03	33.7	COG3324	Predicted enzyme related to lactoylglutathione lyase	127
649950528	357	25.63	1	353	1	347	4.0e-29	122	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
649950529	198	25.39	13	177	5	196	3.0e-11	61.9	COG0778	Nitroreductase	207
649950530	279	41.9	2	179	6	184	5.0e-39	154	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
649950531	247	34.39	1	245	5	250	3.0e-36	145	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649950532	294	36.45	175	281	11	117	9.0e-19	87.6	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
649950534	559	36.36	7	191	4	187	3.0e-21	97.3	COG1475	Chromosome segregation protein Spo0J, contains ParB-like nuclease domain	240
649950537	444	21.94	34	421	23	386	3.0e-05	43.7	COG2814	Predicted arabinose efflux permease, MFS family	394
649950538	266	38.82	4	235	28	255	1.0e-46	180	COG1119	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA	257
649950540	73	37.5	14	69	6	61	4.0e-07	46.4	COG1476	DNA-binding transcriptional regulator, XRE-family HTH domain	68
649950542	400	24.34	17	382	4	360	5.0e-31	129	COG0654	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	387
649950543	341	28.13	6	328	3	303	9.0e-27	114	COG3547	Transposase	303
649950544	215	20.15	54	180	44	173	2.0e-10	59.3	COG3576	Predicted flavin-nucleotide-binding protein, pyridoxine 5'-phosphate oxidase superfamily	173
649950545	194	26.5	1	192	2	201	2.0e-10	59.3	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649950546	184	28.25	9	178	1	177	3.0e-13	68.3	COG2128	Alkylhydroperoxidase family enzyme, contains CxxC motif	177
649950547	99	27.78	1	90	1	90	8.0e-09	52.3	COG1359	Quinol monooxygenase YgiN	100
649950548	248	18.28	7	246	15	282	7.0e-07	47.8	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649950549	359	40.38	1	358	3	358	2.0e-85	309	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
649950551	685	20.43	227	642	148	592	5.0e-24	106	COG3505	Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase	596
649950556	322	39.03	13	318	49	348	6.0e-57	214	COG4962	Pilus assembly protein, ATPase of CpaF family	355
649950557	268	22.42	13	230	18	220	1.0e-03	37.7	COG3701	Type IV secretory pathway, TrbF components	228
649950563	424	22.68	109	414	47	353	8.0e-21	95.1	COG2948	Type IV secretory pathway, VirB10 components	360
649950564	277	23.21	4	276	7	240	1.0e-04	40.8	COG3504	Type IV secretory pathway, VirB9 components	265
649950565	788	23.95	25	720	21	719	5.0e-50	193	COG3451	Type IV secretory pathway, VirB4 component	796
649950568	317	28.23	6	251	2	243	1.0e-23	104	COG0583	DNA-binding transcriptional regulator, LysR family	297
649950569	437	24.73	92	367	25	274	9.0e-06	45.3	COG4973	Site-specific recombinase XerC	299
649950571	223	36.13	19	209	1	175	1.0e-30	126	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649950574	268	41.43	15	265	7	235	1.0e-51	196	COG0571	dsRNA-specific ribonuclease	235
649950575	283	23.03	45	220	10	161	6.0e-12	65	COG0681	Signal peptidase I	166
649950579	263	43.5	1	245	21	258	2.0e-60	226	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
649950580	208	32.95	19	191	4	172	3.0e-24	105	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649950583	266	37.5	3	266	2	243	6.0e-44	170	COG3279	DNA-binding response regulator, LytR/AlgR family	244
649950584	199	26.7	39	196	46	219	1.0e-18	86.9	COG4122	Predicted O-methyltransferase YrrM	219
649950585	331	35.2	34	327	9	305	6.0e-53	201	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
649950589	168	27.22	5	166	37	194	2.0e-14	72.3	COG3230	Heme oxygenase	196
649950593	257	42.99	1	219	4	224	3.0e-61	228	COG1131	ABC-type multidrug transport system, ATPase component	293
649950595	569	25.04	1	567	4	537	9.0e-58	218	COG2303	Choline dehydrogenase or related flavoprotein	542
649950596	258	25.76	1	253	2	261	3.0e-33	135	COG0345	Pyrroline-5-carboxylate reductase	266
649950597	377	43.42	4	376	10	389	1.0e-99	357	COG0153	Galactokinase	390
649950598	343	46.25	9	340	2	329	1.0e-89	323	COG1085	Galactose-1-phosphate uridylyltransferase	338
649950599	221	58.37	1	220	1	221	4.0e-78	284	COG2057	Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit	225
649950600	236	54.13	1	218	1	218	2.0e-75	275	COG1788	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit	220
649950601	329	38.55	3	328	9	308	1.0e-59	223	COG2017	Galactose mutarotase or related enzyme	308
649950602	419	24.4	205	410	8	204	1.0e-15	78.4	COG2755	Lysophospholipase L1 or related esterase	216
649950603	138	53.73	1	134	1	134	5.0e-44	169	COG0105	Nucleoside diphosphate kinase	135
649950604	291	63.92	1	290	1	291	2.0e-112	398	COG0074	Succinyl-CoA synthetase, alpha subunit	293
649950606	389	56.78	1	389	1	385	0.0e+00	490	COG0045	Succinyl-CoA synthetase, beta subunit	387
649950607	345	48.06	12	345	8	336	4.0e-95	341	COG0547	Anthranilate phosphoribosyltransferase	338
649950608	132	27.19	12	124	15	125	2.0e-04	38.7	COG3324	Predicted enzyme related to lactoylglutathione lyase	127
649950609	204	40.86	7	183	4	189	6.0e-51	193	COG1435	Thymidine kinase	201
649950611	505	35.63	6	502	1	491	4.0e-106	378	COG2939	Carboxypeptidase C (cathepsin A)	498
649950613	114	45.05	1	111	1	111	1.0e-30	125	COG4683	Uncharacterized protein	120
649950615	180	38.33	6	173	6	178	3.0e-30	124	COG2032	Cu/Zn superoxide dismutase	179
649950616	272	31.41	80	270	2	181	8.0e-31	127	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
649950619	538	16.41	196	503	44	318	3.0e-03	37.3	COG3595	Uncharacterized conserved protein YvlB, contains  DUF4097 and DUF4098 domains	318
649950620	621	51.36	2	621	5	622	0.0e+00	720	COG0326	Molecular chaperone, HSP90 family	623
649950621	549	21.21	133	548	13	433	3.0e-29	123	COG2234	Zn-dependent amino- or carboxypeptidase, M28 family	435
649950623	465	24.94	28	465	5	408	3.0e-42	166	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
649950632	245	39.3	37	237	6	199	1.0e-35	143	COG2095	Small neutral amino acid transporter SnatA, MarC family	203
649950633	313	39.79	9	292	4	283	2.0e-63	236	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
649950634	358	26.32	41	353	13	300	3.0e-13	69.9	COG3391	DNA-binding beta-propeller fold protein YncE	381
649950636	463	40.92	12	419	3	405	8.0e-106	377	COG1252	NADH dehydrogenase, FAD-containing subunit	405
649950641	325	49.52	12	325	2	305	9.0e-84	303	COG0492	Thioredoxin reductase	305
649950644	103	23.53	1	100	1	98	2.0e-05	40.4	COG3668	Plasmid stabilization system protein ParE	98
649950645	261	38.93	2	244	4	233	6.0e-54	204	COG3910	Predicted ATPase	233
649950647	89	35.23	1	88	1	87	5.0e-13	66.1	COG2026	mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system	90
649950649	235	48.28	1	232	1	228	9.0e-70	256	COG0325	Uncharacterized pyridoxal phosphate-containing protein, affects Ilv metabolism, UPF0001 family	228
649950650	541	31.02	12	434	9	422	4.0e-58	219	COG0025	NhaP-type Na+/H+ or K+/H+ antiporter	429
649950651	626	26.29	49	623	25	556	1.0e-63	238	COG3975	Predicted metalloprotease, contains C-terminal PDZ domain	558
649950652	554	23.13	126	543	10	416	8.0e-26	112	COG2234	Zn-dependent amino- or carboxypeptidase, M28 family	435
649950654	386	31.85	87	356	17	285	2.0e-42	166	COG1295	Uncharacterized membrane protein, BrkB/YihY/UPF0761 family (not an RNase)	303
649950655	309	33.2	38	286	11	250	3.0e-34	139	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
649950656	283	32.8	6	283	2	309	2.0e-69	256	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
649950658	95	50.53	1	94	1	95	1.0e-22	98.1	COG3553	Uncharacterized protein	96
649950661	176	25.83	25	143	11	127	7.0e-12	63.8	COG0526	Thiol-disulfide isomerase or thioredoxin	127
649950662	795	25.73	138	795	71	750	4.0e-49	190	COG4774	Outer membrane receptor for monomeric catechols	750
649950663	374	23.85	12	368	1	383	3.0e-27	116	COG3182	Uncharacterized iron-regulated membrane protein	442
649950665	476	26.73	1	469	2	490	9.0e-39	155	COG0591	Na+/proline symporter	493
649950667	214	22.66	10	206	6	195	1.0e-06	46.9	COG4430	Uncharacterized conserved protein YdeI, YjbR/CyaY-like superfamily, DUF1801 family	200
649950671	300	28.98	6	286	3	259	2.0e-25	109	COG3547	Transposase	303
649950675	134	55.56	13	129	9	125	1.0e-38	152	COG3651	Uncharacterized conserved protein, DUF2237 family	125
649950676	545	38.69	1	541	3	528	0.0e+00	515	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
649950678	412	34.4	8	408	7	405	1.0e-57	217	COG1696	D-alanyl-lipoteichoic acid acyltransferase DltB, MBOAT superfamily	425
649950680	668	30.02	49	668	13	562	5.0e-97	348	COG2936	Predicted acyl esterase	563
649950681	532	36.42	62	525	29	497	3.0e-102	366	COG0513	Superfamily II DNA and RNA helicase	513
649950682	300	26.62	16	294	6	305	7.0e-28	117	COG1216	Glycosyltransferase, GT2 family	305
649950684	531	20.29	30	510	6	473	2.0e-15	77.5	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
649950686	158	58.23	1	158	4	161	8.0e-61	226	COG0225	Peptide methionine sulfoxide reductase MsrA	174
649950687	519	44.03	44	504	3	475	7.0e-116	411	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649950689	520	40.37	36	506	1	475	2.0e-113	403	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649950690	557	38.1	41	526	2	475	2.0e-108	386	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
649950691	321	26.33	2	300	1	291	7.0e-10	58.3	COG0697	Permease of the drug/metabolite transporter (DMT) superfamily	292
649950692	502	23.3	194	390	41	226	3.0e-05	43.8	COG3063	Tfp pilus assembly protein PilF	250
649950693	240	41.54	34	225	38	228	1.0e-34	140	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649950694	477	33.02	165	477	30	329	1.0e-31	131	COG0642	Signal transduction histidine kinase	336
649950695	233	42.42	8	232	2	229	3.0e-52	198	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649950696	108	34.31	1	102	1	101	9.0e-14	68.7	COG1695	DNA-binding transcriptional regulator, PadR family	138
649950697	882	19.19	497	882	6	419	1.0e-13	72.5	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
649950698	1218	23.4	67	940	200	941	1.0e-60	229	COG0383	Alpha-mannosidase	943
649950699	390	23.58	81	377	7	290	5.0e-11	62.5	COG4974	Site-specific recombinase XerD	300
649950702	189	20	24	147	18	145	7.0e-04	37.3	COG4220	Phage DNA packaging protein, Nu1 subunit of terminase	174
649950704	242	34.23	136	242	23	133	8.0e-16	77.3	COG3645	Phage antirepressor protein YoqD, KilAC domain	135
649950723	354	28.96	27	350	16	324	1.0e-41	164	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
649950725	442	27.59	1	418	10	443	1.0e-27	117	COG0531	Amino acid transporter	466
649950727	189	49.7	7	174	2	169	6.0e-45	173	COG0221	Inorganic pyrophosphatase	171
649950728	83	45.78	1	83	2	81	1.0e-18	84.5	COG1828	Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component	83
649950730	393	41.9	10	393	7	351	6.0e-96	344	COG0407	Uroporphyrinogen-III decarboxylase	352
649950731	340	21.16	15	335	3	334	8.0e-27	114	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
649950733	280	44.24	1	268	1	251	3.0e-65	242	COG1521	Pantothenate kinase type III	251
649950734	252	36.4	18	249	1	233	3.0e-42	165	COG0340	Biotin-(acetyl-CoA carboxylase) ligase	238
649950735	298	43.25	8	296	6	280	8.0e-75	273	COG0157	Nicotinate-nucleotide pyrophosphorylase	280
649950737	203	28.97	15	143	7	148	1.0e-20	93.1	COG0328	Ribonuclease HI	154
649950738	161	37.18	5	159	2	148	1.0e-24	105	COG1610	Uncharacterized conserved protein YqeY	148
649950739	423	39.6	1	395	2	383	1.0e-91	330	COG0075	Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG	383
649950740	334	27.53	1	240	1	246	1.0e-20	94.3	COG4219	Signal transducer regulating beta-lactamase production, contains  metallopeptidase domain	337
649950741	122	31.62	4	119	3	118	8.0e-15	72.6	COG3682	Predicted transcriptional regulator	123
649950743	558	18.95	103	545	34	415	2.0e-15	77.7	COG3664	Beta-xylosidase	428
649950744	406	39.48	64	405	2	308	5.0e-65	242	COG2017	Galactose mutarotase or related enzyme	308
649950745	960	47.9	14	957	1	875	0.0e+00	1068	COG0525	Valyl-tRNA synthetase	877
649950746	601	27.68	125	348	28	244	6.0e-26	112	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	254
649950747	226	55.39	1	204	3	205	2.0e-74	272	COG0036	Pentose-5-phosphate-3-epimerase	220
649950752	469	37.95	13	469	4	454	2.0e-92	333	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
649950755	492	43.1	32	490	2	454	1.0e-114	407	COG0312	Predicted Zn-dependent protease or its inactivated homolog	454
649950759	1070	29.02	2	1046	1	1008	0.0e+00	676	COG0841	Multidrug efflux pump subunit AcrB	1009
649950761	586	22.61	97	520	10	371	9.0e-19	89	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
649950762	725	22.69	334	709	101	447	4.0e-25	110	COG1538	Outer membrane protein TolC	457
649950764	611	60.9	5	605	1	601	0.0e+00	891	COG1217	Predicted membrane GTPase involved in stress response	603
649950767	488	60.55	20	487	9	477	0.0e+00	645	COG2308	Uncharacterized conserved protein, circularly permuted ATPgrasp superfamily	488
649950769	332	36.36	1	324	1	309	3.0e-59	222	COG2307	Uncharacterized conserved protein, Alpha-E superfamily	313
649950770	337	28.25	1	296	11	312	3.0e-34	139	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
649950771	658	29.25	48	651	17	556	5.0e-87	315	COG2936	Predicted acyl esterase	563
649950773	275	24.9	32	273	7	255	2.0e-30	126	COG0300	Short-chain dehydrogenase	265
649950774	465	19.95	64	447	59	442	2.0e-32	133	COG0277	FAD/FMN-containing dehydrogenase	459
649950775	135	56.78	1	118	1	118	3.0e-30	123	COG0292	Ribosomal protein L20	118
649950776	108	58.46	44	108	1	65	2.0e-13	67.9	COG0291	Ribosomal protein L35	65
649950778	410	45.3	11	409	1	398	0.0e+00	484	COG4992	Acetylornithine/succinyldiaminopimelate/putrescine aminotransferase	404
649950779	290	48.44	26	280	4	257	3.0e-74	272	COG3739	Uncharacterized membrane protein YoaT, DUF817 family	263
649950780	97	53.85	5	94	6	96	2.0e-23	100	COG3657	Putative component of the toxin-antitoxin plasmid stabilization module	100
649950781	122	41.76	1	90	4	92	6.0e-15	73	COG3636	DNA-binding prophage protein	100
649950782	898	60.75	27	585	1	552	0.0e+00	819	COG0187	DNA gyrase/topoisomerase IV, subunit B	635
649950783	100	31.08	24	97	12	72	6.0e-03	32.6	COG4456	Virulence-associated protein VagC (function unknown)	74
649950784	128	38.1	16	120	26	130	3.0e-18	84.1	COG1487	Predicted nucleic acid-binding protein, contains PIN domain	133
649950785	303	26.63	40	235	12	205	2.0e-09	56.7	COG0705	Membrane associated serine protease, rhomboid family	228
649950789	139	51.97	1	127	1	127	1.0e-35	141	COG4682	Uncharacterized membrane protein YiaA	128
649950790	424	27.19	76	411	6	342	2.0e-52	200	COG0673	Predicted dehydrogenase	342
649950791	138	40	11	138	4	130	7.0e-20	89.7	COG4374	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain)	130
649950792	432	49.43	1	428	1	424	7.0e-122	431	COG0124	Histidyl-tRNA synthetase	429
649950794	175	47.65	1	170	3	171	2.0e-47	181	COG0663	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily	176
649950797	298	19.03	68	292	30	227	7.0e-09	54.9	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
649950799	613	28.45	115	461	4	336	2.0e-37	151	COG0642	Signal transduction histidine kinase	336
649950800	349	25.2	17	131	16	138	8.0e-13	68.5	COG2172	Anti-sigma regulatory factor (Ser/Thr protein kinase)	146
649950801	140	26.62	11	138	5	142	2.0e-15	75	COG2172	Anti-sigma regulatory factor (Ser/Thr protein kinase)	146
649950802	138	28.95	3	115	4	117	9.0e-11	59.3	COG1366	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	117
649950803	293	40.54	163	273	1	111	1.0e-17	83.5	COG1366	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	117
649950809	450	39.21	1	448	2	411	2.0e-72	266	COG1914	Mn2+ and Fe2+ transporters of the NRAMP family	416
649950810	180	42.34	16	152	1	134	8.0e-27	113	COG1321	Mn-dependent transcriptional regulator, DtxR family	154
649950811	429	48.6	1	424	1	424	0.0e+00	481	COG0151	Phosphoribosylamine-glycine ligase	428
649950815	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649950818	92	39.56	1	91	1	89	2.0e-19	87.3	COG2924	Fe-S cluster biosynthesis and repair protein YggX	90
649950819	961	35.64	97	905	62	706	0.0e+00	548	COG0557	Exoribonuclease R	706
649950820	148	29.5	9	147	23	160	5.0e-16	76.9	COG5654	Uncharacterized conserved protein, contains RES domain	163
649950821	149	35.71	40	149	38	149	1.0e-13	68.9	COG5642	Uncharacterized conserved protein, DUF2384 family	149
649950822	391	24.27	16	391	14	368	3.0e-18	86.4	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649950824	548	30.89	76	545	2	487	2.0e-73	270	COG1233	Phytoene dehydrogenase-related protein	487
649950825	351	25.42	1	338	2	315	1.0e-51	196	COG0276	Protoheme ferro-lyase (ferrochelatase)	320
649950826	435	33.41	2	435	1	444	2.0e-71	263	COG1232	Protoporphyrinogen oxidase	444
649950827	173	19.3	13	164	3	170	6.0e-03	34.1	COG1514	2'-5' RNA ligase	180
649950828	492	44.72	3	492	2	464	0.0e+00	525	COG0215	Cysteinyl-tRNA synthetase	464
649950829	370	47.12	5	368	2	334	2.0e-99	356	COG0533	tRNA A37 threonylcarbamoyltransferase TsaD	342
649950831	456	31.26	1	448	4	406	7.0e-69	255	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
649950835	62	57.89	1	57	1	57	4.0e-11	59.9	COG0333	Ribosomal protein L32	57
649950836	338	51.34	3	338	2	334	1.0e-107	382	COG0416	Fatty acid/phospholipid biosynthesis enzyme	338
649950837	321	28.57	14	241	4	207	4.0e-19	89.1	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649950838	966	54.58	9	962	1	859	0.0e+00	1099	COG1048	Aconitase A	861
649950841	711	27.66	60	595	12	467	1.0e-70	261	COG1964	Uncharacterized Fe-S cluster-containing enzyme, radical SAM superfamily	514
649950842	647	29.52	40	635	11	549	8.0e-80	291	COG2936	Predicted acyl esterase	563
649950847	352	36.1	12	351	1	341	1.0e-63	237	COG1816	Adenosine deaminase	345
649950848	352	23.86	5	277	4	276	2.0e-15	76.9	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649950850	537	29.33	33	537	1	459	5.0e-41	162	COG0531	Amino acid transporter	466
649950852	929	47	6	498	1	491	1.0e-128	454	COG0210	Superfamily I DNA or RNA helicase	655
649950854	220	38.05	1	184	16	220	9.0e-33	133	COG3719	Ribonuclease I	249
649950855	424	41.89	12	417	6	393	7.0e-104	371	COG0162	Tyrosyl-tRNA synthetase	401
649950856	415	22.54	5	410	9	444	2.0e-26	113	COG1231	Monoamine oxidase	450
649950857	1008	60.82	19	994	7	978	0.0e+00	1374	COG3383	Predicted molibdopterin-dependent oxidoreductase YjgC	978
649950858	155	28.08	7	150	3	147	2.0e-05	42.3	COG2427	Uncharacterized conserved protein YjgD, DUF1641 family	148
649950859	279	55.96	5	279	2	274	2.0e-101	362	COG2877	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase	279
649950863	254	24.89	30	253	54	253	6.0e-24	104	COG1484	DNA replication protein DnaC	254
649950864	80	44.59	3	73	2	75	4.0e-17	79.9	COG0254	Ribosomal protein L31	75
649950865	409	35.23	23	389	2	320	3.0e-72	266	COG0042	tRNA-dihydrouridine synthase	323
649950868	864	35.77	575	848	33	280	2.0e-52	200	COG2333	Metal-dependent hydrolase, beta-lactamase superfamily II	293
649950869	424	28.67	26	417	29	432	5.0e-61	229	COG2265	tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family	432
649950871	183	26.74	1	179	1	186	1.0e-16	80	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
649950872	211	32.98	22	211	9	192	2.0e-23	102	COG0352	Thiamine monophosphate synthase	211
649950873	469	37.83	1	458	1	454	1.0e-116	413	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
649950874	305	24.31	1	304	5	310	7.0e-14	71.7	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
649950875	90	47.25	1	88	1	91	5.0e-22	96.1	COG3041	mRNA-degrading endonuclease (mRNA interferase) YafQ, toxin component of the YafQ-DinJ toxin-antitoxin module	91
649950876	84	36.78	1	83	1	87	2.0e-08	50.6	COG3077	Antitoxin component of the RelBE or YafQ-DinJ toxin-antitoxin module	88
649950877	269	43.88	1	269	1	273	7.0e-69	254	COG0266	Formamidopyrimidine-DNA glycosylase	273
649950879	453	53.92	14	433	3	423	0.0e+00	572	COG0104	Adenylosuccinate synthase	430
649950880	318	42.99	11	315	9	311	2.0e-78	285	COG0540	Aspartate carbamoyltransferase, catalytic chain	316
649950881	433	41.3	3	433	2	422	1.0e-106	380	COG0044	Dihydroorotase or related cyclic amidohydrolase	430
649950884	178	32.58	2	178	4	178	8.0e-27	113	COG3797	Uncharacterized conserved protein, DUF1697 family	178
649950885	95	33.78	1	74	3	76	4.0e-12	63.1	COG1359	Quinol monooxygenase YgiN	100
649950886	194	53.67	16	191	1	177	5.0e-50	190	COG2065	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase	179
649950889	206	23.42	30	140	1	99	1.0e-09	56.7	COG0789	DNA-binding transcriptional regulator, MerR family	124
649950890	531	27.13	28	522	8	511	7.0e-44	172	COG0728	Peptidoglycan biosynthesis protein MviN/MurJ, putative lipid II flippase	518
649950891	73	51.56	5	68	1	64	6.0e-16	75.8	COG2975	Fe-S-cluster formation regulator IscX/YfhJ	64
649950892	738	29.88	10	720	42	765	7.0e-124	438	COG0243	Anaerobic selenocysteine-containing dehydrogenase	765
649950893	222	32	4	177	8	176	3.0e-30	125	COG3548	Uncharacterized membrane protein	197
649950894	155	25.98	35	154	7	129	3.0e-04	38	COG4319	Ketosteroid isomerase homolog	137
649950898	420	20.34	48	395	42	385	7.0e-07	48.7	COG2814	Predicted arabinose efflux permease, MFS family	394
649950899	422	30.3	229	393	5	168	3.0e-10	60.4	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649950902	402	30.77	234	395	2	151	3.0e-22	99	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
649950904	524	29.32	31	522	29	465	2.0e-56	213	COG2027	D-alanyl-D-alanine carboxypeptidase	470
649950905	118	23.14	1	117	17	126	4.0e-05	40.3	COG2010	Cytochrome c, mono- and diheme variants	150
649950907	306	54.86	15	302	19	302	6.0e-110	390	COG0320	Lipoate synthase	306
649950909	92	25.81	1	92	2	94	4.0e-09	53.1	COG3668	Plasmid stabilization system protein ParE	98
649950911	398	34.52	10	396	3	390	2.0e-83	303	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
649950912	194	46.52	8	194	1	187	8.0e-54	203	COG0233	Ribosome recycling factor	187
649950913	286	41.64	19	282	3	265	7.0e-60	224	COG0294	Dihydropteroate synthase	274
649950914	232	27.14	13	211	4	201	7.0e-11	60.8	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649950915	487	25.89	131	463	78	407	2.0e-54	207	COG1322	DNA anti-recombination protein (rearrangement mutator) RmuC	448
649950917	80	64.1	1	78	3	80	6.0e-12	62.6	COG0236	Acyl carrier protein	80
649950918	419	56.66	7	417	3	411	0.0e+00	494	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
649950919	479	23.7	23	424	20	419	1.0e-19	91.4	COG0531	Amino acid transporter	466
649950921	193	54.55	1	143	34	176	3.0e-48	184	COG0290	Translation initiation factor IF-3	176
649950926	265	53.12	5	260	1	254	7.0e-68	250	COG0134	Indole-3-glycerol phosphate synthase	254
649950927	223	39.46	1	222	2	208	3.0e-42	165	COG0135	Phosphoribosylanthranilate isomerase	208
649950931	344	43.16	1	328	1	314	1.0e-81	296	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
649950934	238	41.81	8	232	70	294	5.0e-51	194	COG4302	Ethanolamine ammonia-lyase, small subunit	294
649950935	450	59.08	1	434	1	435	0.0e+00	648	COG4303	Ethanolamine ammonia-lyase, large subunit	453
649950938	397	19.47	12	390	7	337	1.0e-18	88.1	COG1680	CubicO group peptidase, beta-lactamase class C family	390
649950942	272	50	7	264	1	264	8.0e-99	353	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
649950943	255	22.42	1	222	2	158	9.0e-11	60.8	COG0622	Predicted phosphodiesterase	172
649950944	93	18.29	8	89	6	87	2.0e-03	33.9	COG3609	Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain	89
649950945	96	37.08	4	92	3	90	5.0e-10	55.8	COG3668	Plasmid stabilization system protein ParE	98
649950946	651	44.57	1	538	3	527	0.0e+00	524	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
649950948	325	35.59	120	293	31	197	3.0e-33	135	COG1611	Predicted Rossmann fold nucleotide-binding protein	205
649950950	157	27.34	23	149	48	161	1.0e-11	62.7	COG4731	Uncharacterized conserved protein, DUF2147 family	162
649950951	427	59.72	1	427	1	426	0.0e+00	576	COG0001	Glutamate-1-semialdehyde aminotransferase	432
649950952	360	50.58	18	359	3	342	1.0e-115	409	COG0150	Phosphoribosylaminoimidazole (AIR) synthetase	345
649950953	98	30.61	1	97	2	97	8.0e-10	55.6	COG1669	Predicted nucleotidyltransferase	97
649950954	125	31.82	1	110	1	110	1.0e-19	88.8	COG2361	Uncharacterized conserved protein, contains HEPN domain	117
649950955	202	46.19	3	198	2	197	6.0e-59	220	COG0299	Folate-dependent phosphoribosylglycinamide formyltransferase PurN	200
649950958	371	47.28	49	360	3	289	6.0e-76	278	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
649950959	255	21.48	1	235	11	270	8.0e-09	54.5	COG0682	Prolipoprotein diacylglyceryltransferase	287
649950961	122	24.44	18	105	1	90	2.0e-08	51.1	COG3027	Cell division protein ZapA, inhibits GTPase activity of FtsZ	105
649950963	693	36.15	50	691	15	650	5.0e-129	455	COG0072	Phenylalanyl-tRNA synthetase beta subunit	650
649950964	406	29.17	6	353	16	362	1.0e-30	127	COG1680	CubicO group peptidase, beta-lactamase class C family	390
649950967	187	21.39	2	187	10	196	8.0e-07	47	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649950969	141	22.55	37	131	5	99	4.0e-04	37.3	COG1359	Quinol monooxygenase YgiN	100
649950970	362	27.01	23	360	2	301	2.0e-35	143	COG2152	Predicted glycosyl hydrolase, GH43/DUF377 family	314
649950971	570	47.68	18	338	4	322	7.0e-84	305	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
649950973	346	29.6	184	307	1	125	9.0e-11	61.5	COG0526	Thiol-disulfide isomerase or thioredoxin	127
649950975	103	31.08	1	72	8	81	2.0e-11	60.8	COG2331	Predicted nucleic acid-binding protein, contains Zn-ribbon domain	82
649950978	493	52.49	14	493	5	483	0.0e+00	653	COG0064	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit	483
649950980	704	50.99	1	700	2	667	0.0e+00	830	COG0272	NAD-dependent DNA ligase	667
649950981	348	23.24	1	174	1	176	4.0e-09	55.8	COG1988	Membrane-bound metal-dependent hydrolase YbcI, DUF457 family	190
649950982	237	21.15	27	179	10	160	2.0e-08	53	COG1238	Uncharacterized membrane protein YqaA, SNARE-associated domain	161
649950983	169	43.51	9	159	9	162	3.0e-32	131	COG0521	Molybdopterin biosynthesis enzyme MoaB	169
649950985	318	45.19	2	312	1	306	8.0e-80	290	COG0324	tRNA A37 N6-isopentenylltransferase MiaA	308
649950988	433	48.97	38	425	2	386	1.0e-122	433	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
649950990	171	22.61	40	148	11	124	6.0e-03	34.2	COG4319	Ketosteroid isomerase homolog	137
649950991	439	35.38	164	438	95	367	2.0e-43	170	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
649950993	671	47.56	110	621	24	529	0.0e+00	503	COG0539	Ribosomal protein S1	541
649950995	189	33.99	36	187	1	138	6.0e-27	113	COG0537	Diadenosine tetraphosphate (Ap4A) hydrolase or other HIT family hydrolase	138
649950997	144	35.43	11	137	12	132	3.0e-21	94.5	COG0848	Biopolymer transport protein ExbD	137
649950998	140	37.68	1	138	1	135	1.0e-27	115	COG0848	Biopolymer transport protein ExbD	137
649950999	248	32.41	34	248	1	215	1.0e-30	126	COG0811	Biopolymer transport protein ExbB/TolQ	216
649951000	248	22.56	56	246	65	244	7.0e-09	54.4	COG0810	Periplasmic protein TonB, links inner and outer membranes	244
649951001	320	40.98	8	312	9	302	7.0e-74	270	COG0341	Preprotein translocase subunit SecF	305
649951002	535	35.57	1	535	1	506	3.0e-92	332	COG0342	Preprotein translocase subunit SecD	506
649951003	104	40.22	13	104	5	95	2.0e-16	77.2	COG1862	Preprotein translocase subunit YajC	97
649951005	91	36.49	14	87	1	74	1.0e-11	61.3	COG1837	Predicted RNA-binding protein YlqC, contains KH domain, UPF0109 family	76
649951009	441	42.19	73	435	20	384	1.0e-99	356	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
649951010	328	26.87	1	319	2	307	4.0e-34	138	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649951011	400	45.85	1	398	2	409	9.0e-104	370	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
649951012	99	29.33	1	74	2	76	6.0e-05	39.1	COG0236	Acyl carrier protein	80
649951014	374	52.73	5	370	1	344	3.0e-124	438	COG0343	Queuine/archaeosine tRNA-ribosyltransferase	372
649951018	93	40.43	1	92	1	94	2.0e-20	90.7	COG3549	Plasmid maintenance system killer protein	94
649951019	110	46.24	18	110	8	98	2.0e-19	87.7	COG3093	Plasmid maintenance system antidote protein VapI, contains XRE-type HTH domain	104
649951021	346	38.4	1	345	1	339	8.0e-104	370	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
649951022	244	36.51	2	242	1	251	2.0e-43	169	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649951023	243	38.49	2	241	1	251	5.0e-40	158	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649951024	334	35.92	224	326	19	121	5.0e-21	95.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
649951025	748	30.41	45	635	114	671	5.0e-99	355	COG1501	Alpha-glucosidase, glycosyl hydrolase family GH31	772
649951031	133	22.9	1	126	24	154	2.0e-05	41.3	COG4961	Flp pilus assembly protein TadG	185
649951032	528	24.83	74	217	14	154	5.0e-04	39.7	COG4961	Flp pilus assembly protein TadG	185
649951035	973	45.7	52	909	11	802	0.0e+00	847	COG0188	DNA gyrase/topoisomerase IV, subunit A	804
649951036	321	24.29	66	309	2	220	1.0e-16	81	COG3039	Transposase and inactivated derivatives, IS5 family	230
649951042	1008	24.06	98	890	30	727	6.0e-97	349	COG4775	Outer membrane protein assembly factor BamA	766
649951043	422	34.02	25	404	11	397	4.0e-38	152	COG0025	NhaP-type Na+/H+ or K+/H+ antiporter	429
649951044	452	20.45	316	446	13	144	5.0e-08	52.8	COG1714	Uncharacterized membrane protein YckC, RDD family	172
649951048	244	29.38	19	193	14	190	9.0e-06	44.3	COG1309	DNA-binding transcriptional regulator, AcrR family	201
649951049	292	29.5	1	271	2	275	4.0e-20	92.3	COG0702	Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains	275
649951050	325	29.08	99	292	59	243	3.0e-18	86.4	COG1651	Protein-disulfide isomerase	244
649951051	377	16.43	57	337	19	279	6.0e-04	38.9	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
649951052	152	37.97	50	127	24	100	2.0e-10	58.9	COG0633	Ferredoxin	102
649951053	667	49.01	5	605	6	579	0.0e+00	540	COG0443	Molecular chaperone DnaK (HSP70)	579
649951054	144	23.78	12	143	1	135	4.0e-18	83.8	COG2764	Uncharacterized conserved protein PhnB, glyoxalase superfamily	136
649951056	448	28.89	5	440	14	410	1.0e-51	198	COG2124	Cytochrome P450	411
649951057	296	26.71	1	285	1	231	1.0e-20	94	COG3416	Uncharacterized protein	233
649951059	164	43.55	40	163	1	109	3.0e-28	118	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
649951060	140	51.35	1	129	5	148	3.0e-35	140	COG0822	NifU homolog involved in Fe-S cluster formation	150
649951061	436	54.87	35	420	1	386	0.0e+00	542	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
649951062	163	35.37	2	148	1	139	3.0e-28	117	COG1959	DNA-binding transcriptional regulator, IscR family	150
649951063	194	30.32	1	184	5	190	8.0e-12	63.9	COG0558	Phosphatidylglycerophosphate synthase	192
649951065	63	48.28	1	56	1	58	3.0e-14	69.9	COG0227	Ribosomal protein L28	77
649951066	136	58.59	9	135	1	128	5.0e-56	209	COG0229	Peptide methionine sulfoxide reductase MsrB	140
649951067	133	52.34	5	132	3	128	1.0e-35	141	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
649951070	311	30.13	1	301	1	300	1.0e-51	197	COG1893	Ketopantoate reductase	307
649951071	709	39.64	42	707	2	648	0.0e+00	537	COG1505	Prolyl oligopeptidase PreP, S9A serine peptidase family	648
649951072	826	44.28	92	823	6	701	0.0e+00	805	COG0317	(p)ppGpp synthase/hydrolase, HD superfamily	701
649951074	94	36.96	1	91	1	92	4.0e-14	69.6	COG3553	Uncharacterized protein	96
649951075	499	53.62	23	486	1	457	0.0e+00	607	COG0034	Glutamine phosphoribosylpyrophosphate amidotransferase	470
649951076	785	45.11	27	773	22	743	0.0e+00	814	COG0046	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain	743
649951077	150	48.94	13	149	9	146	1.0e-30	125	COG0756	dUTPase	148
649951078	448	26.77	12	260	19	282	3.0e-19	90.1	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649951079	517	22.74	11	516	9	538	3.0e-45	176	COG2303	Choline dehydrogenase or related flavoprotein	542
649951081	344	25.45	2	318	1	314	9.0e-34	137	COG0451	Nucleoside-diphosphate-sugar epimerase	314
649951082	107	52.94	1	99	1	102	8.0e-24	102	COG0261	Ribosomal protein L21	103
649951083	91	62.35	1	85	1	85	2.0e-27	113	COG0211	Ribosomal protein L27	87
649951084	102	33	1	99	3	97	3.0e-14	70.2	COG1669	Predicted nucleotidyltransferase	97
649951085	115	29.82	1	114	2	114	2.0e-18	84.6	COG2361	Uncharacterized conserved protein, contains HEPN domain	117
649951086	339	62.95	3	334	1	332	0.0e+00	477	COG2255	Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit	332
649951087	241	31.53	13	231	4	209	2.0e-33	136	COG0177	Endonuclease III	211
649951088	220	33.94	1	216	3	220	2.0e-29	122	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
649951089	297	30.85	12	291	12	282	2.0e-52	199	COG0676	D-hexose-6-phosphate mutarotase	287
649951090	197	51.85	1	189	4	184	6.0e-56	210	COG0424	Predicted house-cleaning NTP pyrophosphatase, Maf/HAM1 superfamily	193
649951091	308	44.44	8	280	4	282	4.0e-81	295	COG0774	UDP-3-O-acyl-N-acetylglucosamine deacetylase	300
649951092	157	47.17	1	157	2	153	8.0e-40	156	COG0801	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	160
649951093	300	56.04	4	300	1	294	6.0e-94	337	COG2103	N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase	298
649951094	316	43.56	6	308	4	300	2.0e-68	252	COG1446	Isoaspartyl peptidase or L-asparaginase, Ntn-hydrolase superfamily	307
649951095	210	25	15	205	1	192	6.0e-16	77.7	COG0558	Phosphatidylglycerophosphate synthase	192
649951098	173	43.75	6	149	6	148	1.0e-24	105	COG0782	Transcription elongation factor, GreA/GreB family	151
649951101	327	38.3	1	322	17	341	4.0e-77	281	COG1559	Cell division protein YceG, involved in septum cleavage	342
649951103	346	26.94	1	339	2	334	4.0e-27	116	COG0673	Predicted dehydrogenase	342
649951105	375	35.26	1	373	3	352	1.0e-77	283	COG0787	Alanine racemase	360
649951106	462	45.79	16	453	4	434	2.0e-123	435	COG0305	Replicative DNA helicase	435
649951108	230	54.37	45	204	1	159	3.0e-61	228	COG0225	Peptide methionine sulfoxide reductase MsrA	174
649951110	672	52.7	4	669	2	620	0.0e+00	852	COG0445	tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA	621
649951111	94	28.57	3	84	1	84	6.0e-05	39.3	COG3609	Transcriptional regulator, contains Arc/MetJ-type RHH (ribbon-helix-helix) DNA-binding domain	89
649951112	95	31.25	1	95	2	97	1.0e-07	48.1	COG3668	Plasmid stabilization system protein ParE	98
649951113	326	25.63	3	197	8	206	3.0e-21	96.1	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
649951116	365	50.86	1	345	2	345	9.0e-127	446	COG0536	GTPase involved in cell partioning and DNA repair	369
649951117	205	38.42	4	205	1	197	2.0e-43	168	COG1057	Nicotinic acid mononucleotide adenylyltransferase	197
649951118	181	43.59	5	120	2	115	7.0e-24	103	COG0799	Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits	115
649951119	343	27.52	6	328	3	303	7.0e-29	121	COG3547	Transposase	303
649951120	152	40.97	17	149	12	154	1.0e-26	112	COG1576	23S rRNA pseudoU1915 N3-methylase RlmH	155
649951122	567	31.93	36	564	4	498	2.0e-98	353	COG3534	Alpha-L-arabinofuranosidase	501
649951123	289	59.23	1	283	1	287	9.0e-109	386	COG0777	Acetyl-CoA carboxylase beta subunit	294
649951124	216	35.41	4	211	1	205	5.0e-44	170	COG0288	Carbonic anhydrase	207
649951125	307	36.95	48	296	56	295	4.0e-55	208	COG3781	Predicted membrane chloride channel, bestrophin family	306
649951129	156	73.33	7	156	5	154	7.0e-61	226	COG3558	Uncharacterized conserved protein, nuclear transport factor 2 (NTF2) superfamily	154
649951132	196	38.12	1	196	1	201	1.0e-46	179	COG0632	Holliday junction resolvasome RuvABC DNA-binding subunit	201
649951133	229	30.91	1	220	1	219	1.0e-16	80.3	COG1842	Phage shock protein A	225
649951135	490	26.51	4	429	12	489	6.0e-35	142	COG2268	Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain	548
649951138	303	33.54	1	303	1	326	4.0e-47	182	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
649951139	166	21.58	1	133	1	138	5.0e-04	37.4	COG4276	Ligand-binding SRPBCC domain	153
649951141	466	42.32	1	454	2	483	0.0e+00	503	COG0364	Glucose-6-phosphate 1-dehydrogenase	483
649951142	338	52.51	1	338	1	299	1.0e-116	413	COG1023	6-phosphogluconate dehydrogenase (decarboxylating)	300
649951144	456	44.32	6	456	2	454	1.0e-125	443	COG0486	tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE	454
649951145	230	31.28	1	225	3	228	4.0e-32	131	COG5587	Uncharacterized conserved protein, DUF2461 family	228
649951146	98	40.86	5	97	2	94	3.0e-13	67.1	COG0776	Bacterial nucleoid DNA-binding protein	94
649951147	242	24	13	176	9	183	9.0e-11	60.8	COG2020	Protein-S-isoprenylcysteine O-methyltransferase Ste14	187
649951148	454	31.12	45	425	27	402	3.0e-58	219	COG1228	Imidazolonepropionase or related amidohydrolase	406
649951149	301	33.98	37	291	6	240	1.0e-32	133	COG1475	Chromosome segregation protein Spo0J, contains ParB-like nuclease domain	240
649951150	277	41.47	15	270	1	253	1.0e-55	210	COG1192	Cellulose biosynthesis protein BcsQ	259
649951153	252	37.44	23	238	29	238	5.0e-39	154	COG2071	Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD (putrescine degradation), contains GATase1-like domain	243
649951154	244	29.25	13	221	2	208	4.0e-24	105	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
649951157	204	36.84	1	203	1	202	9.0e-48	183	COG1182	FMN-dependent NADH-azoreductase	202
649951159	687	51.12	106	684	21	584	0.0e+00	700	COG0441	Threonyl-tRNA synthetase	589
649951161	136	60.53	16	53	12	49	5.0e-09	53.6	COG4338	Uncharacterized protein	54
649951163	607	36.17	315	591	44	314	2.0e-49	190	COG0706	Membrane protein insertase Oxa1/YidC/SpoIIIJ, required for the localization of integral membrane proteins	314
649951164	78	46.48	8	78	9	75	3.0e-17	80.4	COG0759	Membrane-anchored protein YidD, putatitve component of membrane protein insertase Oxa1/YidC/SpoIIIJ	92
649951165	128	37.96	10	116	5	106	7.0e-13	66.1	COG0594	RNase P protein component	117
649951166	51	60.47	3	45	2	44	1.0e-03	34.8	COG0230	Ribosomal protein L34	44
649951167	428	25.55	64	426	16	368	2.0e-45	176	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
649951170	1145	23.74	370	986	50	572	2.0e-68	254	COG1523	Pullulanase/glycogen debranching enzyme	697
649951172	244	42.65	43	244	1	211	2.0e-47	182	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649951174	310	27.27	22	300	2	279	5.0e-25	108	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
649951175	443	18.75	79	429	56	381	2.0e-05	44.4	COG2814	Predicted arabinose efflux permease, MFS family	394
649951177	449	22.61	43	438	4	340	5.0e-33	135	COG0673	Predicted dehydrogenase	342
649951179	256	40.47	13	254	4	251	1.0e-37	149	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649951180	607	18.98	33	607	8	614	7.0e-44	172	COG1874	Beta-galactosidase GanA	673
649951182	489	16.49	24	489	25	458	2.0e-22	100	COG0277	FAD/FMN-containing dehydrogenase	459
649951183	373	42.53	32	373	5	345	2.0e-67	250	COG2706	6-phosphogluconolactonase, cycloisomerase 2 family	346
649951184	438	31.73	25	409	4	381	5.0e-63	235	COG3964	Predicted amidohydrolase	386
649951185	532	23.65	49	380	8	340	4.0e-32	133	COG1921	Seryl-tRNA(Sec) selenium transferase	395
649951186	160	30.33	48	160	9	128	2.0e-16	78.4	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
649951187	421	24.83	33	322	1	290	8.0e-25	108	COG1921	Seryl-tRNA(Sec) selenium transferase	395
649951188	278	33.17	69	272	11	203	9.0e-29	120	COG0684	Regulator of RNase E activity RraA	210
649951190	207	44.29	4	205	1	210	9.0e-50	189	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649951191	1033	25.25	722	1013	76	363	3.0e-36	148	COG4585	Signal transduction histidine kinase	365
649951192	435	22.45	5	432	24	438	6.0e-27	115	COG2271	Sugar phosphate permease	448
649951193	479	47.25	45	477	1	430	0.0e+00	483	COG3538	Meiotically up-regulated gene 157 (Mug157) protein (function unknown)	434
649951194	452	33.64	24	445	3	430	2.0e-89	323	COG3669	Alpha-L-fucosidase	430
649951196	262	30.71	28	261	29	282	2.0e-19	89.7	COG0790	TPR repeat	292
649951199	467	35.21	66	463	39	421	4.0e-68	252	COG2379	Glycerate-2-kinase	422
649951200	260	38.08	17	250	3	241	1.0e-39	156	COG2186	DNA-binding transcriptional regulator, FadR family	241
649951201	439	21.53	11	426	9	430	1.0e-15	77.9	COG2271	Sugar phosphate permease	448
649951205	1195	18.56	100	972	71	897	3.0e-32	134	COG4934	Serine protease, subtilase family	1174
649951206	660	28.32	4	116	5	115	1.0e-16	82.3	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	148
649951207	513	18.36	62	332	8	309	8.0e-11	62.3	COG1228	Imidazolonepropionase or related amidohydrolase	406
649951208	449	28.67	156	445	17	303	9.0e-36	145	COG2421	Acetamidase/formamidase	305
649951211	216	38.21	4	215	1	211	4.0e-42	164	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
649951215	289	29.67	46	286	1	246	3.0e-35	142	COG1414	DNA-binding transcriptional regulator, IclR family	246
649951216	270	39.15	16	269	14	264	8.0e-65	240	COG0179	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	266
649951217	447	25.82	4	426	1	371	1.0e-55	210	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
649951218	250	39.15	2	246	1	250	6.0e-37	147	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649951219	260	37.74	3	254	1	251	2.0e-37	149	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649951220	288	28.1	11	280	10	276	2.0e-39	155	COG3618	Predicted metal-dependent hydrolase, TIM-barrel fold	279
649951222	366	19.73	32	251	12	221	2.0e-04	40.4	COG2801	Transposase InsO and inactivated derivatives	232
649951223	489	21.71	55	430	1	495	4.0e-35	142	COG0366	Glycosidase	505
649951225	501	29.17	9	152	5	146	3.0e-18	86.9	COG3710	DNA-binding winged helix-turn-helix (wHTH) domain	148
649951227	527	17.42	115	524	10	399	3.0e-25	110	COG3464	Transposase	402
649951230	338	23.01	8	336	43	376	5.0e-13	68.8	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
649951233	342	23.03	8	326	14	366	6.0e-18	85.2	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
649951235	932	28.36	134	329	24	223	7.0e-24	106	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
649951236	401	18.73	55	401	28	368	2.0e-13	70.4	COG3524	Capsule polysaccharide export protein KpsE/RkpR	372
649951237	316	21.02	14	308	4	304	8.0e-16	78.2	COG1216	Glycosyltransferase, GT2 family	305
649951239	412	23.6	1	407	1	381	9.0e-26	111	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649951242	317	24.7	62	305	2	220	2.0e-16	80.2	COG3039	Transposase and inactivated derivatives, IS5 family	230
649951248	486	22.79	65	468	41	386	1.0e-13	71.4	COG2814	Predicted arabinose efflux permease, MFS family	394
649951259	283	19.73	32	251	12	221	7.0e-04	38	COG2801	Transposase InsO and inactivated derivatives	232
649951261	324	17.82	32	288	14	275	1.0e-11	64.2	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	299
649951266	345	15.22	164	295	11	141	4.0e-03	36.1	COG1853	NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family	176
649951268	745	31.27	82	405	53	378	8.0e-52	199	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
649951269	393	45.59	2	388	1	395	2.0e-121	429	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
649951270	379	47.16	1	377	6	393	1.0e-119	423	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
649951272	117	32.38	3	107	2	105	5.0e-13	66.4	COG1993	PII-like signaling protein	109
649951273	450	25.47	26	449	21	445	5.0e-32	132	COG1538	Outer membrane protein TolC	457
649951274	406	28.68	1	392	5	366	1.0e-23	104	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
649951275	1065	29.41	1	1049	2	1005	0.0e+00	636	COG0841	Multidrug efflux pump subunit AcrB	1009
649951276	229	42.73	1	221	1	225	5.0e-54	204	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
649951277	468	34.16	143	463	17	328	1.0e-39	157	COG0642	Signal transduction histidine kinase	336
649951279	444	26.34	1	443	10	444	4.0e-27	116	COG1538	Outer membrane protein TolC	457
649951281	1034	30.63	18	1030	9	1008	0.0e+00	619	COG0841	Multidrug efflux pump subunit AcrB	1009
649951283	213	49.28	1	209	1	208	4.0e-61	227	COG2808	Predicted FMN-binding regulatory protein PaiB	209
649951286	393	40.62	9	390	5	389	5.0e-105	374	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
649951287	294	41.9	190	294	18	122	2.0e-24	106	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
649951288	148	21.38	11	144	5	148	1.0e-03	35.7	COG2427	Uncharacterized conserved protein YjgD, DUF1641 family	148
649951289	1005	60.9	16	992	1	977	0.0e+00	1378	COG3383	Predicted molibdopterin-dependent oxidoreductase YjgC	978
649951290	311	37.59	12	292	4	260	6.0e-61	227	COG1526	Formate dehydrogenase assembly factor FdhD	266
649951293	416	33.65	208	413	1	203	8.0e-39	154	COG2140	Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily	209
649951294	381	48.1	18	359	6	340	1.0e-86	313	COG3569	DNA topoisomerase IB	354
649951296	495	37.83	1	486	5	490	8.0e-103	367	COG1070	Sugar (pentulose or hexulose) kinase	502
649951299	128	26.5	11	127	7	121	5.0e-07	46.8	COG4272	Uncharacterized membrane protein	125
649951300	278	31.39	1	273	1	254	3.0e-12	65.8	COG0730	Uncharacterized membrane protein YfcA	258
649951301	420	34.12	211	414	1	205	2.0e-37	150	COG2140	Oxalate decarboxylase/archaeal phosphoglucose isomerase, cupin superfamily	209
649951302	297	35.71	6	293	2	289	8.0e-34	137	COG0583	DNA-binding transcriptional regulator, LysR family	297
649951303	419	32.45	93	389	3	299	8.0e-43	168	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
649951304	892	31.99	48	438	35	388	2.0e-60	228	COG1472	Periplasmic beta-glucosidase and related glycosidases	397
649951305	438	59.82	1	438	1	438	0.0e+00	654	COG2115	Xylose isomerase	438
649951309	621	27.39	29	620	3	604	2.0e-70	260	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
649951310	258	28.71	21	227	4	209	1.0e-26	113	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649951311	205	23.47	14	204	3	198	3.0e-17	81.8	COG0664	cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases	214
649951312	421	26.92	10	403	48	460	4.0e-46	179	COG0155	Sulfite reductase, beta subunit (hemoprotein)	510
649951313	207	53.69	2	203	3	203	1.0e-58	219	COG2082	Precorrin isomerase	210
649951314	507	48.41	253	503	1	245	2.0e-84	306	COG1010	Precorrin-3B methylase	249
649951315	407	43.62	223	407	1	187	1.0e-53	204	COG2242	Precorrin-6B methylase 2	187
649951317	249	53.31	1	241	3	243	8.0e-91	326	COG2875	Precorrin-4 methylase	254
649951318	258	43.55	9	247	2	248	1.0e-61	230	COG2099	Precorrin-6x reductase	257
649951319	253	22.66	1	253	1	233	1.0e-27	117	COG2243	Precorrin-2 methylase	234
649951320	400	21.36	13	394	11	399	4.0e-23	102	COG2072	Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD	443
649951322	688	18.12	11	456	15	456	4.0e-20	93.6	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
649951323	246	33.14	54	223	40	209	9.0e-20	90.6	COG1596	Periplasmic protein involved in polysaccharide export, contains SLBB domain of the beta-grasp fold	239
649951325	426	18.93	25	414	14	404	1.0e-14	74.4	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
649951326	494	21.39	76	424	52	402	9.0e-12	65.6	COG3307	O-antigen ligase	424
649951327	422	19.93	128	406	72	369	3.0e-09	57	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
649951328	315	20.36	7	277	2	271	6.0e-18	85.2	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
649951331	238	23.77	1	222	2	257	2.0e-14	72.5	COG1192	Cellulose biosynthesis protein BcsQ	259
649951333	250	43.2	3	247	2	249	2.0e-49	188	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
649951334	286	25.43	1	286	3	265	5.0e-35	141	COG0300	Short-chain dehydrogenase	265
649951337	355	46.3	117	278	1	159	3.0e-38	152	COG4804	Predicted nuclease of restriction endonuclease-like (RecB) superfamily,  DUF1016 family	159
649951338	134	26.15	1	129	47	176	3.0e-15	74.1	COG2128	Alkylhydroperoxidase family enzyme, contains CxxC motif	177
649951342	555	20.05	105	519	12	398	8.0e-25	108	COG1228	Imidazolonepropionase or related amidohydrolase	406
649951346	391	21.84	5	367	6	409	3.0e-08	53.3	COG0738	Fucose permease	422
649951347	359	36.09	15	343	1	333	6.0e-68	251	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
649951349	424	28.31	103	410	29	356	2.0e-50	193	COG4225	Rhamnogalacturonyl hydrolase YesR	357
649951350	553	25.37	111	312	35	238	4.0e-11	63.4	COG3063	Tfp pilus assembly protein PilF	250
649951354	513	36.92	36	512	2	488	4.0e-99	355	COG2272	Carboxylesterase type B	491
649951355	471	24.39	39	471	11	429	5.0e-52	199	COG5520	O-Glycosyl hydrolase	433
650638068	342	22.41	77	302	17	220	9.0e-11	61.3	COG3039	Transposase and inactivated derivatives, IS5 family	230
650638071	188	37.04	1	159	1	160	3.0e-22	98.3	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
650638083	406	48.05	135	387	1	255	1.0e-66	247	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
650638086	173	51.94	7	128	5	133	9.0e-39	153	COG2110	O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain	179
650638089	150	28.57	13	121	12	121	2.0e-08	51.4	COG1943	REP element-mobilizing transposase RayT	136
650638090	95	29.76	1	84	2	83	8.0e-07	45.4	COG4118	Antitoxin component of toxin-antitoxin stability system, DNA-binding transcriptional repressor	84
650638098	206	25.54	10	186	4	186	4.0e-17	81.6	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
650638101	1210	27.52	464	786	3	303	3.0e-31	131	COG3547	Transposase	303
650638107	326	33.7	4	187	15	198	4.0e-24	105	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
650638125	1525	24.11	3	280	22	294	1.0e-11	66.8	COG3291	PKD repeat	297
650638135	337	33.02	227	332	18	123	6.0e-20	91.8	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
650638141	526	17.38	115	523	10	399	3.0e-25	110	COG3464	Transposase	402
650638143	99	36.73	2	99	3	100	6.0e-13	65.8	COG1733	DNA-binding transcriptional regulator, HxlR family	120
650638149	93	25.26	2	92	4	90	6.0e-04	36	COG2929	Uncharacterized conserved protein, DUF497 family	93
650638150	67	30.3	1	65	2	67	2.0e-05	41	COG2929	Uncharacterized conserved protein, DUF497 family	93
650638218	163	24.24	54	152	11	108	4.0e-10	57.6	COG0607	Rhodanese-related sulfurtransferase	110
650638885	320	15.94	66	314	2	230	9.0e-08	51.3	COG3039	Transposase and inactivated derivatives, IS5 family	230
650638891	96	48.45	1	96	3	99	3.0e-23	100	COG3657	Putative component of the toxin-antitoxin plasmid stabilization module	100
650638897	93	50.56	1	88	11	99	3.0e-20	90	COG3636	DNA-binding prophage protein	100
650638919	284	29.73	8	118	6	111	2.0e-05	43	COG3415	Transposase	138
650638921	207	37.59	1	137	18	158	6.0e-23	100	COG4804	Predicted nuclease of restriction endonuclease-like (RecB) superfamily,  DUF1016 family	159
650639785	342	27.85	6	301	3	274	3.0e-27	116	COG3547	Transposase	303
