gene_oid	gene_length	percent_identity	query_start	query_end	subj_start	subj_end	evalue	bit_score	cog_id	cog_name	cog_length
646477355	570	41.69	231	548	85	400	4.0e-71	262	COG0593	Chromosomal replication initiation ATPase DnaA	408
646477359	269	33.9	1	235	2	209	2.0e-26	113	COG0705	Membrane associated serine protease, rhomboid family	228
646477360	264	40.74	1	232	1	235	9.0e-60	223	COG3546	Mn-containing catalase (includes spore coat protein CotJC)	277
646477363	130	49.59	8	127	7	127	2.0e-33	134	COG0295	Cytidine deaminase	134
646477364	405	44.44	5	405	4	403	3.0e-106	379	COG1972	Nucleoside permease NupC	404
646477365	212	51.67	1	207	1	209	2.0e-67	248	COG0035	Uracil phosphoribosyltransferase	210
646477369	172	47.83	4	161	1	158	3.0e-46	177	COG2077	Peroxiredoxin	158
646477373	874	25.82	577	864	3	292	9.0e-35	142	COG2333	Metal-dependent hydrolase, beta-lactamase superfamily II	293
646477375	524	37.14	3	524	10	472	1.0e-109	390	COG0008	Glutamyl- or glutaminyl-tRNA synthetase	472
646477377	496	22.94	192	455	27	293	7.0e-07	49.2	COG0501	Zn-dependent protease with chaperone function	302
646477379	251	40.55	3	249	1	251	1.0e-44	173	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646477384	119	35.59	1	118	1	112	4.0e-18	83.3	COG0347	Nitrogen regulatory protein PII	112
646477385	170	48.05	11	164	1	150	1.0e-49	189	COG0219	tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain	155
646477393	387	40.16	12	385	31	410	4.0e-97	348	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
646477394	279	21.28	22	270	18	279	3.0e-14	72.8	COG1234	Ribonuclease BN, tRNA processing enzyme	292
646477396	201	20.35	33	193	20	166	2.0e-06	46.1	COG2825	Periplasmic chaperone for outer membrane proteins, Skp family	170
646477397	666	32.82	10	658	4	633	1.0e-107	384	COG1199	Rad3-related DNA helicase	654
646477398	606	23.94	408	595	6	180	2.0e-11	64.5	COG2881	Uncharacterized protein	181
646477399	361	22.94	167	336	8	162	2.0e-08	54.1	COG2881	Uncharacterized protein	181
646477402	420	45.23	55	414	12	373	6.0e-108	384	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
646477403	381	33.16	98	287	7	195	3.0e-37	149	COG1611	Predicted Rossmann fold nucleotide-binding protein	205
646477407	438	21.57	175	421	6	236	1.0e-08	54.6	COG1409	3',5'-cyclic AMP phosphodiesterase CpdA	301
646477408	139	24.79	13	125	9	124	9.0e-12	62.7	COG2172	Anti-sigma regulatory factor (Ser/Thr protein kinase)	146
646477409	121	29.35	30	121	23	114	1.0e-10	58.5	COG1366	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	117
646477410	145	26.43	1	129	11	150	1.0e-10	59.2	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
646477412	1487	31.27	166	456	1	303	5.0e-40	161	COG0515	Serine/threonine protein kinase	384
646477415	273	33.61	3	238	4	243	4.0e-35	141	COG2218	Formylmethanofuran dehydrogenase subunit C	264
646477416	213	25	3	209	19	192	2.0e-17	83.1	COG0746	Molybdopterin-guanine dinucleotide biosynthesis protein A	192
646477418	558	44.15	15	552	6	564	0.0e+00	557	COG1229	Formylmethanofuran dehydrogenase subunit A	575
646477422	230	42.29	4	229	3	228	4.0e-55	208	COG0274	Deoxyribose-phosphate aldolase	228
646477423	307	25.16	1	305	3	274	2.0e-29	123	COG1082	Sugar phosphate isomerase/epimerase	274
646477424	383	29.79	1	382	1	341	4.0e-48	185	COG0673	Predicted dehydrogenase	342
646477428	379	37.58	62	363	41	326	8.0e-61	227	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
646477433	865	28.54	422	845	141	569	4.0e-68	253	COG4232	Thiol:disulfide interchange protein	569
646477434	523	53.24	5	523	1	515	0.0e+00	666	COG0138	AICAR transformylase/IMP cyclohydrolase PurH	515
646477436	305	22.64	5	290	2	292	2.0e-08	53.7	COG5006	Threonine/homoserine efflux transporter RhtA	292
646477437	549	33.46	11	546	2	480	9.0e-81	294	COG1233	Phytoene dehydrogenase-related protein	487
646477443	547	40.57	9	531	10	508	0.0e+00	492	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component	526
646477444	258	38.61	1	257	5	257	5.0e-47	181	COG1024	Enoyl-CoA hydratase/carnithine racemase	257
646477447	419	60.54	5	411	7	412	0.0e+00	634	COG0112	Glycine/serine hydroxymethyltransferase	413
646477448	565	27.69	71	443	1	383	8.0e-39	155	COG0515	Serine/threonine protein kinase	384
646477449	303	23.04	60	273	65	292	5.0e-13	68.6	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
646477450	272	38.52	5	272	1	260	6.0e-49	187	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
646477451	303	26.35	1	296	1	260	1.0e-20	93.8	COG0575	CDP-diglyceride synthetase	265
646477452	251	50.43	18	249	14	245	4.0e-78	284	COG0020	Undecaprenyl pyrophosphate synthase	245
646477453	428	53.44	2	420	7	424	0.0e+00	544	COG0104	Adenylosuccinate synthase	430
646477455	468	41.81	238	468	1	226	5.0e-68	252	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
646477456	111	40.91	14	99	11	95	1.0e-11	61.5	COG3695	Alkylated DNA nucleotide flippase Atl1, participates in nucleotide excision repair, Ada-like DNA-binding domain	103
646477459	604	26.8	69	566	10	437	2.0e-71	263	COG1109	Phosphomannomutase	464
646477460	353	55.69	13	346	4	319	1.0e-86	313	COG4864	Uncharacterized protein YqfA, UPF0365 family	328
646477462	305	44.06	11	295	1	286	3.0e-75	275	COG2084	3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase	286
646477464	129	27.68	8	119	11	122	2.0e-15	74.4	COG0818	Diacylglycerol kinase	123
646477465	1091	15.91	319	1073	73	758	2.0e-12	68.5	COG1452	LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA)	784
646477467	309	32.05	18	276	26	268	4.0e-65	241	COG2326	Polyphosphate kinase 2, PPK2 family	270
646477468	654	38.15	43	289	1	236	4.0e-52	199	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	238
646477469	453	34.66	4	253	5	252	4.0e-44	172	COG1774	Cell fate regulator YaaT, PSP1 superfamily (controls sporulation, competence, biofilm development)	265
646477471	350	21.69	12	341	8	238	3.0e-15	76.1	COG0176	Transaldolase	239
646477473	195	29.86	1	195	3	220	6.0e-20	90.6	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
646477478	505	15.56	10	178	11	178	4.0e-06	46.7	COG4961	Flp pilus assembly protein TadG	185
646477481	326	31.35	60	309	64	314	2.0e-19	89.9	COG2064	Pilus assembly protein TadC	320
646477482	318	33.87	73	317	62	308	2.0e-36	146	COG4965	Flp pilus assembly protein TadB	309
646477483	473	52.1	46	402	4	355	8.0e-111	394	COG4962	Pilus assembly protein, ATPase of CpaF family	355
646477485	471	28.97	7	471	3	450	3.0e-49	190	COG0534	Na+-driven multidrug efflux pump	455
646477486	292	39.52	1	124	1	87	2.0e-17	83.1	COG2088	DNA-binding protein SpoVG, cell septation regulator	95
646477487	336	32.91	8	319	2	282	4.0e-55	208	COG1947	4-diphosphocytidyl-2C-methyl-D-erythritol kinase	289
646477488	435	22.03	55	344	2	275	6.0e-17	82.2	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646477489	334	31.74	40	332	7	278	2.0e-54	206	COG3618	Predicted metal-dependent hydrolase, TIM-barrel fold	279
646477493	413	38.46	6	81	5	82	7.0e-14	71.9	COG3831	WGR domain, predicted DNA-binding domain in MolR	85
646477497	446	28.5	23	429	10	409	1.0e-66	247	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
646477504	381	46.77	10	372	3	374	8.0e-120	423	COG0562	UDP-galactopyranose mutase	374
646477506	422	35.5	12	396	11	394	8.0e-85	307	COG0019	Diaminopimelate decarboxylase	394
646477508	696	37.81	1	543	3	557	0.0e+00	572	COG0143	Methionyl-tRNA synthetase	558
646477509	265	27.67	1	251	3	248	4.0e-25	108	COG1427	Predicted periplasmic solute-binding protein	252
646477510	382	42.18	8	360	9	366	5.0e-107	381	COG1060	2-iminoacetate synthase ThiH (tyrosine cleavage enzyme, thamine biosynthesis)	370
646477513	186	44.32	3	183	2	178	3.0e-33	135	COG1437	Adenylate cyclase class IV, CYTH domain (includes archaeal enzymes of unknown function)	178
646477514	637	21.69	370	637	14	350	1.0e-11	65.4	COG1858	Cytochrome c peroxidase	364
646477515	254	43.98	9	246	5	237	5.0e-62	230	COG1212	CMP-2-keto-3-deoxyoctulosonic acid synthetase	247
646477516	545	62.92	2	535	1	533	0.0e+00	868	COG0504	CTP synthase (UTP-ammonia lyase)	533
646477518	826	21.67	8	788	5	722	2.0e-71	264	COG1033	Predicted exporter protein, RND superfamily	727
646477519	445	46.73	9	445	3	436	3.0e-120	425	COG1875	Predicted ribonuclease YlaK, contains NYN-type RNase and PhoH-family ATPase domains	436
646477520	359	31.27	19	352	3	334	1.0e-47	184	COG0859	ADP-heptose:LPS heptosyltransferase	334
646477521	641	45.64	303	641	8	351	2.0e-104	373	COG0407	Uroporphyrinogen-III decarboxylase	352
646477522	342	26.99	14	308	10	333	1.0e-31	130	COG3621	Patatin-like phospholipase/acyl hydrolase	394
646477523	165	28.57	88	163	4	80	2.0e-11	62.6	COG0236	Acyl carrier protein	80
646477528	905	17.42	216	542	15	290	1.0e-05	46.5	COG0501	Zn-dependent protease with chaperone function	302
646477530	673	31.95	311	647	16	319	2.0e-39	157	COG0142	Geranylgeranyl pyrophosphate synthase	322
646477532	420	22.41	1	403	2	368	3.0e-24	106	COG0644	Dehydrogenase (flavoprotein)	396
646477534	213	41.71	11	209	1	199	4.0e-50	191	COG4566	Two-component response regulator, FixJ family, consists of REC and HTH domains	202
646477536	266	34.6	8	243	1	229	3.0e-52	198	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646477545	486	29.16	27	459	2	450	1.0e-55	210	COG3119	Arylsulfatase A or related enzyme	475
646477547	501	47.68	1	494	3	494	0.0e+00	549	COG2317	Zn-dependent carboxypeptidase, M32 family	497
646477551	275	27.76	1	269	3	272	5.0e-29	121	COG1082	Sugar phosphate isomerase/epimerase	274
646477553	363	28.57	1	292	1	290	9.0e-37	147	COG0583	DNA-binding transcriptional regulator, LysR family	297
646477554	1527	58.87	718	1210	2	485	0.0e+00	662	COG0069	Glutamate synthase domain 2	485
646477555	504	41.36	23	485	2	451	0.0e+00	468	COG0493	NADPH-dependent glutamate synthase beta chain or related oxidoreductase	457
646477558	320	21.94	2	155	6	147	2.0e-07	50	COG2165	Type II secretory pathway, pseudopilin PulG	149
646477560	166	43.98	1	166	1	130	1.0e-31	129	COG1970	Large-conductance mechanosensitive channel	130
646477561	619	39.35	89	614	46	567	2.0e-121	429	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
646477565	314	23.03	7	309	2	276	1.0e-26	113	COG0863	DNA modification methylase	302
646477566	132	40.91	15	102	6	93	2.0e-09	55.2	COG0640	DNA-binding transcriptional regulator, ArsR family	110
646477570	311	37.58	8	309	2	314	8.0e-66	244	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646477571	405	42.54	138	405	39	289	4.0e-62	232	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646477572	337	56.15	7	322	1	313	2.0e-122	432	COG0444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component	316
646477574	73	47.46	12	69	3	61	3.0e-11	60.4	COG3369	Uncharacterized protein, contains Zn-finger domain of CDGSH type	78
646477577	189	35.52	4	186	1	182	2.0e-27	115	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646477578	434	42.26	16	419	1	392	1.0e-91	330	COG1092	23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI	393
646477580	1070	21.94	216	879	175	782	9.0e-30	126	COG4258	Predicted exporter	788
646477582	176	32.59	22	156	6	140	4.0e-22	98	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
646477583	287	33.17	18	214	26	226	2.0e-34	139	COG0220	tRNA G46 methylase TrmB	227
646477594	421	34.74	9	419	5	402	1.0e-78	287	COG0520	Selenocysteine lyase/Cysteine desulfurase	405
646477595	426	33.41	14	425	17	437	9.0e-69	254	COG1541	Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family	438
646477596	465	20.71	29	451	15	385	3.0e-08	53.7	COG2814	Predicted arabinose efflux permease, MFS family	394
646477597	515	37.89	42	489	5	451	6.0e-108	384	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
646477598	955	55.02	19	955	6	935	0.0e+00	1283	COG0178	Excinuclease UvrABC ATPase subunit	935
646477600	79	61.54	1	78	3	80	1.0e-12	64.6	COG0236	Acyl carrier protein	80
646477601	434	49.65	1	431	1	410	4.0e-127	448	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646477606	398	54.81	146	384	1	239	3.0e-78	285	COG1186	Protein chain release factor B	239
646477607	169	36.47	3	165	18	185	2.0e-30	125	COG2320	GrpB domain, predicted nucleotidyltransferase, UPF0157 family	185
646477610	513	34.06	22	323	1	317	5.0e-42	165	COG0515	Serine/threonine protein kinase	384
646477616	887	17.33	5	458	3	411	7.0e-09	56.6	COG1061	Superfamily II DNA or RNA helicase	442
646477624	195	21.99	8	194	3	176	2.0e-07	49.3	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646477625	1003	22.12	118	433	4	279	7.0e-21	96.8	COG0515	Serine/threonine protein kinase	384
646477628	153	69.39	6	152	7	152	5.0e-54	203	COG3558	Uncharacterized conserved protein, nuclear transport factor 2 (NTF2) superfamily	154
646477629	320	24.65	37	314	2	279	4.0e-26	112	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646477630	195	32.1	18	171	15	176	2.0e-11	62.5	COG2128	Alkylhydroperoxidase family enzyme, contains CxxC motif	177
646477631	539	45.15	101	537	97	547	2.0e-113	402	COG3604	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains	550
646477633	427	33.33	1	420	8	467	3.0e-62	232	COG3119	Arylsulfatase A or related enzyme	475
646477648	299	19.42	9	271	51	291	4.0e-10	59.2	COG2333	Metal-dependent hydrolase, beta-lactamase superfamily II	293
646477653	496	30.21	2	191	1	178	5.0e-13	69.4	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
646477654	268	30.21	8	99	1	96	1.0e-10	60.5	COG3293	Transposase	124
646477660	203	30.32	15	202	4	182	1.0e-12	67	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646477661	1172	35.56	108	370	2	282	8.0e-40	159	COG0515	Serine/threonine protein kinase	384
646477662	739	25.91	35	732	5	680	2.0e-85	310	COG1770	Protease II	682
646477674	305	23.31	8	139	3	135	4.0e-09	55.8	COG2165	Type II secretory pathway, pseudopilin PulG	149
646477679	441	31.99	80	420	4	320	5.0e-60	225	COG0205	6-phosphofructokinase	347
646477680	442	19.89	25	362	34	383	9.0e-16	78.3	COG0606	Predicted ATPase with chaperone activity	490
646477684	273	46.64	56	271	20	241	3.0e-58	218	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
646477685	142	39.42	1	134	1	136	8.0e-25	106	COG1959	DNA-binding transcriptional regulator, IscR family	150
646477686	262	53.12	5	259	1	254	8.0e-81	293	COG0134	Indole-3-glycerol phosphate synthase	254
646477688	398	35.6	24	390	6	342	4.0e-81	295	COG1194	Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs	342
646477689	735	42.19	69	727	3	648	0.0e+00	602	COG1505	Prolyl oligopeptidase PreP, S9A serine peptidase family	648
646477694	309	24.03	10	286	38	297	2.0e-20	93.5	COG2382	Enterochelin esterase or related enzyme	299
646477701	58	42.31	4	55	5	56	6.0e-06	42.5	COG3847	Flp pilus assembly protein, pilin Flp	58
646477703	417	30.77	1	417	8	436	5.0e-69	255	COG0612	Predicted Zn-dependent peptidase	438
646477704	395	19.45	1	391	1	360	7.0e-18	85.4	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
646477706	357	21.94	50	354	27	378	2.0e-31	130	COG4692	Predicted neuraminidase (sialidase)	381
646477708	400	45.78	10	399	6	385	2.0e-87	316	COG4398	Small ligand-binding sensory domain FIST	389
646477709	351	42.74	2	349	1	341	9.0e-84	304	COG0430	RNA 3'-terminal phosphate cyclase	341
646477710	498	31.32	21	492	1	432	2.0e-72	267	COG1690	RNA-splicing ligase RtcB, repairs tRNA damage	432
646477713	540	60.34	5	533	2	522	0.0e+00	652	COG4650	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain	531
646477716	379	26.12	71	341	21	297	1.0e-26	114	COG0714	MoxR-like ATPase	329
646477719	259	32.53	86	251	9	168	2.0e-24	106	COG1386	Chromosome segregation and condensation protein ScpB	184
646477721	335	29.79	56	140	5	97	9.0e-08	51.4	COG3453	Predicted phosphohydrolase, protein tyrosine phosphatase (PTP) superfamily, DUF442 family	130
646477726	274	28.92	1	274	1	281	4.0e-31	128	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646477727	215	37.86	3	208	2	169	1.0e-32	133	COG2862	Uncharacterized membrane protein YqhA	169
646477728	684	35.38	42	682	13	649	7.0e-130	458	COG0072	Phenylalanyl-tRNA synthetase beta subunit	650
646477729	345	47.8	10	344	6	335	2.0e-107	382	COG0016	Phenylalanyl-tRNA synthetase alpha subunit	335
646477730	124	49.14	1	116	2	117	1.0e-25	108	COG0292	Ribosomal protein L20	118
646477731	67	44.62	1	65	1	65	4.0e-07	46.4	COG0291	Ribosomal protein L35	65
646477733	476	51.2	1	459	1	459	0.0e+00	531	COG0165	Argininosuccinate lyase	459
646477737	424	43.87	1	424	1	413	9.0e-105	374	COG0373	Glutamyl-tRNA reductase	414
646477741	284	38.18	63	227	11	173	3.0e-35	142	COG1386	Chromosome segregation and condensation protein ScpB	184
646477742	279	39.31	1	259	2	251	3.0e-52	198	COG1192	Cellulose biosynthesis protein BcsQ	259
646477743	255	38.89	63	255	2	197	1.0e-40	160	COG0288	Carbonic anhydrase	207
646477744	507	27.88	21	504	1	466	1.0e-52	201	COG3119	Arylsulfatase A or related enzyme	475
646477748	526	25.31	7	485	4	459	6.0e-49	189	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646477751	421	26.96	1	421	23	451	6.0e-51	195	COG4325	Uncharacterized membrane protein	464
646477752	415	32.73	67	394	7	316	5.0e-73	268	COG1899	Deoxyhypusine synthase	318
646477757	202	39.78	10	186	14	193	3.0e-40	158	COG1611	Predicted Rossmann fold nucleotide-binding protein	205
646477758	519	45.45	7	519	2	521	0.0e+00	538	COG3540	Phosphodiesterase/alkaline phosphatase D	522
646477766	234	17.84	33	232	7	217	2.0e-07	49.5	COG0819	Thiaminase	218
646477798	194	35.18	4	191	3	198	1.0e-23	103	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
646477809	104	29.41	17	100	14	98	3.0e-06	43.6	COG0640	DNA-binding transcriptional regulator, ArsR family	110
646477810	306	34.55	1	109	2	110	4.0e-12	65.7	COG0607	Rhodanese-related sulfurtransferase	110
646477811	465	26.61	9	229	20	252	9.0e-17	81.8	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646477812	275	30.86	1	269	5	251	5.0e-11	62	COG0730	Uncharacterized membrane protein YfcA	258
646477813	400	21.23	12	352	1	336	3.0e-30	126	COG0446	NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase	415
646477816	709	47.25	10	701	5	667	0.0e+00	722	COG1331	Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains	667
646477818	151	25.81	29	119	24	116	2.0e-06	45.4	COG1366	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	117
646477821	318	56.66	21	312	14	301	4.0e-113	401	COG0320	Lipoate synthase	306
646477822	262	26.85	23	237	16	211	1.0e-19	90.3	COG0321	Lipoate-protein ligase B	221
646477823	179	49.33	29	178	3	151	2.0e-47	181	COG0691	tmRNA-binding protein	153
646477824	228	40.09	1	214	1	216	8.0e-60	223	COG1136	ABC-type lipoprotein export system, ATPase component	226
646477826	767	27.8	396	578	70	254	1.0e-16	82.3	COG5426	Uncharacterized membrane protein	254
646477828	742	24.79	271	742	2	431	6.0e-31	129	COG1030	Membrane-bound serine protease (ClpP class)	436
646477831	73	63.38	3	73	2	72	6.0e-21	92.2	COG0361	Translation initiation factor IF-1	75
646477834	174	44.44	10	172	5	170	1.0e-33	135	COG3153	Predicted N-acetyltransferase YhbS	171
646477835	1206	22.03	15	376	1	383	3.0e-24	108	COG0515	Serine/threonine protein kinase	384
646477836	383	29.63	142	373	1	243	1.0e-27	118	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
646477840	465	47.56	15	457	6	453	0.0e+00	471	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646477841	211	38.35	9	209	1	200	7.0e-38	150	COG1974	SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase)	201
646477842	164	67.5	5	164	1	158	1.0e-60	225	COG0041	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase	162
646477843	379	45.18	8	369	1	361	5.0e-113	401	COG0026	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)	375
646477849	269	23.75	3	263	5	227	2.0e-30	126	COG3253	Chlorite dismutase	230
646477851	541	48.43	22	530	5	502	0.0e+00	593	COG3046	Uncharacterized protein related to deoxyribodipyrimidine photolyase	505
646477853	248	29.19	24	217	12	219	3.0e-29	121	COG0220	tRNA G46 methylase TrmB	227
646477855	364	28.3	67	330	5	263	8.0e-35	141	COG2006	Uncharacterized conserved protein, DUF362 family	293
646477863	220	41.87	23	217	50	252	3.0e-43	168	COG2041	Periplasmic DMSO/TMAO reductase YedYZ, molybdopterin-dependent catalytic subunit	271
646477866	410	47.72	10	400	9	388	3.0e-103	368	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
646477867	295	25.64	6	267	16	270	8.0e-30	124	COG0863	DNA modification methylase	302
646477868	380	46.22	11	378	4	369	2.0e-110	393	COG0263	Glutamate 5-kinase	369
646477869	591	17.91	22	155	19	148	2.0e-07	50.9	COG4961	Flp pilus assembly protein TadG	185
646477870	153	53.73	1	134	2	135	3.0e-48	184	COG0105	Nucleoside diphosphate kinase	135
646477878	418	27.97	1	389	23	401	2.0e-46	180	COG0585	tRNA(Glu) U13 pseudouridine synthase TruD	406
646477880	573	45.49	64	562	5	496	0.0e+00	528	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646477881	378	53.6	6	351	5	351	2.0e-125	442	COG2805	Tfp pilus assembly protein PilT, pilus retraction ATPase	353
646477882	572	47.14	64	570	5	500	0.0e+00	516	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646477883	474	36.1	1	349	1	330	1.0e-66	247	COG1459	Type II secretory pathway, component PulF	397
646477884	304	30.48	22	118	3	107	8.0e-10	58.1	COG2165	Type II secretory pathway, pseudopilin PulG	149
646477885	352	23.08	10	126	1	114	6.0e-08	52.4	COG2165	Type II secretory pathway, pseudopilin PulG	149
646477889	155	55.7	1	148	4	152	2.0e-48	185	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
646477891	328	32.3	1	305	1	307	3.0e-52	199	COG1087	UDP-glucose 4-epimerase	329
646477892	162	23.58	27	149	17	138	4.0e-06	44.5	COG5652	VanZ like family protein (function unknown)	148
646477894	341	37.41	6	281	1	274	1.0e-64	240	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646477901	507	37.34	1	397	11	383	1.0e-77	283	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	406
646477902	161	25.32	5	157	2	155	3.0e-18	84.5	COG2606	Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC	155
646477905	817	30.99	492	794	40	345	2.0e-37	151	COG4782	Esterase/lipase superfamily enzyme	377
646477908	312	36.77	1	306	2	300	1.0e-54	207	COG1597	Diacylglycerol kinase family enzyme	301
646477909	235	43.15	35	231	20	209	2.0e-49	189	COG2258	Uncharacterized conserved protein YiiM, contains MOSC domain	210
646477911	189	36.42	16	186	5	177	1.0e-19	89.8	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646477917	350	31.34	1	345	4	362	8.0e-47	181	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646477925	572	31.9	8	563	1	532	5.0e-94	338	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
646477927	269	36.05	3	258	4	192	1.0e-43	170	COG2094	3-methyladenine DNA glycosylase Mpg	200
646477928	1041	24.23	91	748	82	650	7.0e-76	279	COG0209	Ribonucleotide reductase alpha subunit	696
646477929	114	39.13	2	114	1	112	3.0e-25	106	COG0537	Diadenosine tetraphosphate (Ap4A) hydrolase or other HIT family hydrolase	138
646477930	337	40.06	1	333	1	336	1.0e-94	339	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
646477932	290	29.73	32	282	53	297	1.0e-32	133	COG2382	Enterochelin esterase or related enzyme	299
646477933	164	32.54	12	136	1	126	2.0e-10	58.8	COG1846	DNA-binding transcriptional regulator, MarR family	126
646477938	336	38.95	62	325	18	277	3.0e-57	215	COG1398	Fatty-acid desaturase	289
646477942	608	38.83	1	487	1	524	4.0e-120	425	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646477944	110	37.89	15	109	7	99	5.0e-16	76	COG0023	Translation initiation factor 1 (eIF-1/SUI1)	104
646477946	316	58.9	4	294	2	293	2.0e-111	395	COG0761	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH	294
646477947	539	18.18	153	460	60	289	4.0e-10	60.1	COG2159	Predicted metal-dependent hydrolase, TIM-barrel fold	293
646477948	748	28.97	33	303	1	282	9.0e-37	149	COG0515	Serine/threonine protein kinase	384
646477949	600	24.78	302	527	3	214	5.0e-18	86.4	COG2114	Adenylate cyclase, class 3	227
646477951	327	30.67	3	77	1	75	4.0e-07	49.1	COG4537	Competence protein ComGC	107
646477955	64	42.86	19	60	8	49	9.0e-06	41.9	COG5583	Uncharacterized protein	54
646477956	362	55.56	1	356	1	342	4.0e-106	378	COG1118	ABC-type sulfate/molybdate transport systems, ATPase component	345
646477957	294	70.26	15	283	14	282	2.0e-105	375	COG4208	ABC-type sulfate transport system, permease component	287
646477958	278	54.31	7	273	5	271	5.0e-70	257	COG0555	ABC-type sulfate transport system, permease component	274
646477959	377	60.85	22	376	10	346	0.0e+00	477	COG1613	ABC-type sulfate transport system, periplasmic component	348
646477960	533	38.17	23	516	47	545	2.0e-100	360	COG3604	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains	550
646477962	109	43.43	8	106	6	104	1.0e-23	101	COG1324	Uncharacterized protein involved in tolerance to divalent cations	104
646477964	268	45.56	5	268	1	266	2.0e-70	259	COG0289	Dihydrodipicolinate reductase	266
646477965	466	34.99	29	429	24	389	8.0e-76	277	COG0498	Threonine synthase	411
646477967	615	25	24	174	8	160	6.0e-07	49.6	COG0681	Signal peptidase I	166
646477968	302	57.32	1	237	2	239	8.0e-92	330	COG1137	ABC-type lipopolysaccharide export system, ATPase component	243
646477972	480	22.34	39	421	3	339	1.0e-22	101	COG0673	Predicted dehydrogenase	342
646477980	224	23.55	7	221	23	281	1.0e-05	43.5	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646477985	384	27.79	42	366	20	342	1.0e-38	154	COG3177	Fic family protein	348
646477987	167	26.28	2	154	7	156	1.0e-09	56.4	COG4894	Uncharacterized protein YxjI	159
646477990	285	40.85	4	284	3	281	4.0e-65	241	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
646477991	270	47.79	43	267	1	220	1.0e-71	263	COG1136	ABC-type lipoprotein export system, ATPase component	226
646477992	510	31.87	173	510	96	408	3.0e-49	190	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
646477994	528	46.03	19	527	14	502	0.0e+00	547	COG1190	Lysyl-tRNA synthetase (class II)	502
646477998	260	24.14	14	260	14	271	2.0e-18	86	COG1082	Sugar phosphate isomerase/epimerase	274
646478008	389	31.87	136	388	15	284	5.0e-28	118	COG1408	Predicted phosphohydrolase, MPP superfamily	284
646478011	447	47.17	7	446	7	434	1.0e-130	460	COG0213	Thymidine phosphorylase	435
646478015	117	57.02	3	116	2	115	6.0e-40	155	COG4898	Uncharacterized protein	115
646478016	133	37.69	1	130	1	116	1.0e-21	95.5	COG5507	Uncharacterized  conserved protein YbaA, DUF1428 family	117
646478017	437	29.09	243	350	18	126	4.0e-10	59.5	COG0526	Thiol-disulfide isomerase or thioredoxin	127
646478027	242	29.03	1	238	3	250	2.0e-25	109	COG0388	Predicted amidohydrolase	274
646478031	893	28.73	14	889	1	740	0.0e+00	573	COG0574	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase	740
646478033	1181	20.53	2	473	1	396	2.0e-17	85.5	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646478034	603	21.05	374	603	48	350	8.0e-08	52.7	COG1858	Cytochrome c peroxidase	364
646478039	376	24.11	1	362	1	388	2.0e-30	126	COG3182	Uncharacterized iron-regulated membrane protein	442
646478043	404	29.32	1	394	2	381	1.0e-74	273	COG0763	Lipid A disaccharide synthetase	381
646478047	281	24.62	3	251	1	262	2.0e-30	126	COG1082	Sugar phosphate isomerase/epimerase	274
646478049	377	29.26	2	377	1	340	2.0e-57	216	COG0673	Predicted dehydrogenase	342
646478057	150	29.46	5	116	4	115	1.0e-12	65.8	COG1734	RNA polymerase-binding transcription factor DksA	120
646478060	302	21.15	27	302	14	261	8.0e-20	91.2	COG3878	Uncharacterized protein YwqG	261
646478062	132	32.93	18	99	3	81	2.0e-08	51.2	COG2261	Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family	82
646478063	297	49.16	1	294	1	297	1.0e-87	316	COG2037	Formylmethanofuran:tetrahydromethanopterin formyltransferase	297
646478065	407	31.1	11	392	6	408	7.0e-56	211	COG0486	tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE	454
646478066	502	17.91	24	491	4	418	9.0e-28	118	COG0415	Deoxyribodipyrimidine photolyase	461
646478068	327	43.22	1	316	2	307	1.0e-77	283	COG0223	Methionyl-tRNA formyltransferase	307
646478069	222	46.45	29	181	2	156	6.0e-50	190	COG0242	Peptide deformylase	168
646478075	357	47.49	95	308	55	262	3.0e-50	192	COG0489	Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster	265
646478077	482	28.06	6	459	114	560	5.0e-45	175	COG3829	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding Fis domains	560
646478078	544	35.98	4	503	1	466	7.0e-67	248	COG1007	NADH:ubiquinone oxidoreductase subunit 2 (chain N)	475
646478079	600	44.62	1	558	5	497	3.0e-128	452	COG1008	NADH:ubiquinone oxidoreductase subunit 4 (chain M)	497
646478081	147	41.18	10	94	7	91	1.0e-19	89	COG0713	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)	100
646478082	328	32.77	71	189	1	117	1.0e-13	71	COG0839	NADH:ubiquinone oxidoreductase subunit 6 (chain J)	166
646478083	185	38.12	27	183	15	162	8.0e-28	117	COG1143	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)	172
646478084	409	42.98	2	349	12	326	1.0e-78	287	COG1005	NADH:ubiquinone oxidoreductase subunit 1 (chain H)	332
646478086	450	50.58	1	430	6	423	0.0e+00	540	COG1894	NADH:ubiquinone oxidoreductase, NADH-binding 51 kD subunit (chain F)	424
646478087	166	36.94	10	166	4	159	7.0e-33	133	COG1905	NADH:ubiquinone oxidoreductase 24 kD subunit (chain E)	160
646478088	404	52.33	19	404	16	398	0.0e+00	485	COG0649	NADH:ubiquinone oxidoreductase 49 kD subunit (chain D)	398
646478090	192	54.71	7	175	19	187	2.0e-60	225	COG0377	NADH:ubiquinone oxidoreductase 20 kD subunit (chhain B) or related Fe-S oxidoreductase	194
646478091	143	35.66	1	143	4	121	3.0e-21	94.5	COG0838	NADH:ubiquinone oxidoreductase subunit 3 (chain A)	123
646478097	309	25.79	60	301	66	312	9.0e-22	97.7	COG0657	Acetyl esterase/lipase	312
646478108	152	23.31	1	150	3	165	3.0e-12	64.2	COG2318	Uncharacterized damage-inducible protein DinB (forms a four-helix bundle)	172
646478109	800	43.87	24	659	1	649	0.0e+00	544	COG0210	Superfamily I DNA or RNA helicase	655
646478110	482	25.44	40	431	4	335	9.0e-42	165	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646478112	505	41.03	113	499	32	402	8.0e-78	284	COG1301	Na+/H+-dicarboxylate symporter	415
646478115	392	41.6	4	347	1	322	2.0e-84	306	COG0205	6-phosphofructokinase	347
646478118	475	43.07	1	460	2	436	3.0e-129	455	COG0621	tRNA A37 methylthiotransferase MiaB	437
646478120	126	56	1	125	1	125	9.0e-48	181	COG0853	Aspartate 1-decarboxylase	126
646478124	544	41.02	21	534	9	530	5.0e-123	435	COG0578	Glycerol-3-phosphate dehydrogenase	532
646478125	497	61.41	1	495	4	498	0.0e+00	747	COG0554	Glycerol kinase	499
646478126	272	51.82	22	266	29	266	2.0e-73	268	COG0179	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)	266
646478127	120	35.78	3	109	18	125	2.0e-19	87.6	COG1832	Predicted CoA-binding protein	140
646478128	358	41.36	41	335	3	292	6.0e-67	248	COG1533	DNA repair photolyase	297
646478130	220	24	6	205	4	201	5.0e-15	74.7	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646478132	303	45.57	140	296	3	151	4.0e-42	165	COG3865	Glyoxalase superfamily enzyme, possibly 3-demethylubiquinone-9 3-methyltransferase	151
646478134	146	37.68	5	140	1	133	6.0e-24	103	COG2764	Uncharacterized conserved protein PhnB, glyoxalase superfamily	136
646478135	249	36.89	1	119	1	122	3.0e-26	112	COG3795	Uncharacterized conserved protein	123
646478137	474	53.6	2	473	1	462	0.0e+00	632	COG0114	Fumarate hydratase class II	462
646478139	480	30.07	9	451	2	411	1.0e-58	221	COG2124	Cytochrome P450	411
646478140	430	40.38	6	430	5	403	1.0e-106	380	COG2081	Predicted flavoprotein YhiN	408
646478141	590	35.47	36	589	1	535	2.0e-99	356	COG1574	Predicted amidohydrolase YtcJ	535
646478143	464	34.17	63	455	42	421	1.0e-68	254	COG2379	Glycerate-2-kinase	422
646478144	417	21.23	10	332	12	320	1.0e-06	47.9	COG2223	Nitrate/nitrite transporter NarK	417
646478145	265	29.37	10	261	7	255	2.0e-34	139	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	255
646478146	472	20.36	107	371	91	351	4.0e-11	62.9	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646478153	169	39.45	35	141	9	117	2.0e-13	69	COG0517	CBS domain	117
646478154	655	27.2	251	626	2	359	2.0e-52	200	COG0674	Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, alpha subunit	365
646478158	296	25.19	1	260	3	249	2.0e-21	96.8	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646478159	317	29.24	9	290	4	297	3.0e-32	132	COG1397	ADP-ribosylglycohydrolase	314
646478162	465	21.51	29	403	1	446	1.0e-28	121	COG3540	Phosphodiesterase/alkaline phosphatase D	522
646478163	527	21.43	233	526	59	366	1.0e-19	92	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
646478165	333	33.85	9	327	3	291	9.0e-62	231	COG1131	ABC-type multidrug transport system, ATPase component	293
646478167	347	42.5	1	332	15	359	5.0e-78	284	COG3437	Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains	360
646478168	1314	38.42	8	400	4	400	9.0e-116	412	COG0004	Ammonia channel protein AmtB	409
646478169	368	20.2	2	302	1	298	6.0e-14	72.1	COG1216	Glycosyltransferase, GT2 family	305
646478170	253	43.25	1	249	3	253	5.0e-68	250	COG0024	Methionine aminopeptidase	255
646478171	352	36.54	64	315	54	301	2.0e-48	186	COG0616	Periplasmic serine protease, ClpP class	317
646478172	250	20	1	232	3	256	2.0e-11	62.5	COG1082	Sugar phosphate isomerase/epimerase	274
646478174	623	52.97	55	455	7	405	2.0e-103	370	COG4651	Predicted Kef-type K+ transport protein, K+/H+ antiporter domain	408
646478175	168	53.16	1	158	1	158	7.0e-38	150	COG3685	Ferritin-like metal-binding protein YciE	167
646478178	81	40	1	65	3	67	1.0e-10	58	COG3237	Uncharacterized conserved protein YjbJ, UPF0337 family	67
646478182	319	37.93	1	315	1	316	4.0e-69	255	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
646478189	641	57.07	1	607	1	579	0.0e+00	656	COG0443	Molecular chaperone DnaK (HSP70)	579
646478190	364	45.35	96	358	5	273	1.0e-77	284	COG0077	Prephenate dehydratase	279
646478191	266	33.74	7	249	2	238	2.0e-51	195	COG0327	Putative GTP cyclohydrolase 1 type 2, NIF3 family	250
646478193	173	48.52	3	171	1	169	3.0e-49	188	COG1778	 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC and related HAD superfamily phosphatases	170
646478194	365	53.23	18	216	2	202	6.0e-55	208	COG0794	D-arabinose 5-phosphate isomerase GutQ	202
646478196	338	43.94	1	329	1	286	1.0e-96	347	COG0191	Fructose/tagatose bisphosphate aldolase	286
646478198	423	17.05	40	389	6	318	6.0e-11	62.4	COG3239	Fatty acid desaturase	343
646478200	330	38.21	1	330	1	326	1.0e-66	247	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646478203	350	41.47	6	337	4	335	7.0e-64	237	COG3367	Uncharacterized conserved protein, NAD-dependent epimerase/dehydratase family	339
646478209	677	46.94	41	655	8	601	0.0e+00	571	COG0653	Preprotein translocase subunit SecA (ATPase, RNA helicase)	822
646478213	316	20.17	12	126	15	132	3.0e-08	53	COG2009	Succinate dehydrogenase/fumarate reductase, cytochrome b subunit	132
646478214	671	34.94	3	621	6	562	1.0e-125	444	COG1053	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit	562
646478215	299	28.25	28	295	1	234	2.0e-49	189	COG0479	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit	234
646478219	1032	42.08	547	1026	5	472	4.0e-123	436	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646478222	493	16.94	32	305	8	289	3.0e-10	60.2	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646478223	193	59.12	35	193	6	162	2.0e-62	231	COG0386	Glutathione peroxidase, house-cleaning role in reducing lipid peroxides	162
646478228	483	24.28	8	469	3	474	3.0e-30	126	COG3349	Uncharacterized conserved protein, contains NAD-binding domain and a Fe-S cluster	485
646478229	296	34.78	9	281	5	279	2.0e-38	153	COG1562	Phytoene/squalene synthetase	288
646478230	309	29.54	20	298	4	284	7.0e-39	154	COG1562	Phytoene/squalene synthetase	288
646478232	466	30.77	1	465	1	427	4.0e-81	295	COG1236	RNA processing exonuclease, beta-lactamase fold, Cft2 family	427
646478235	238	22.5	92	232	1	154	3.0e-10	59.1	COG1225	Peroxiredoxin	157
646478239	272	22.55	14	113	8	101	5.0e-06	45.1	COG3293	Transposase	124
646478243	505	31.52	34	490	4	460	1.0e-54	208	COG3119	Arylsulfatase A or related enzyme	475
646478244	887	18.93	322	710	15	399	4.0e-09	57.3	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646478247	245	39.68	4	244	3	246	1.0e-46	180	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
646478248	370	28.65	10	175	1	171	7.0e-15	75.2	COG1714	Uncharacterized membrane protein YckC, RDD family	172
646478249	331	25.13	110	299	17	201	3.0e-14	73	COG1300	Uncharacterized membrane protein SpoIIM, required for sporulation	207
646478253	359	44.44	42	358	7	329	2.0e-69	256	COG0714	MoxR-like ATPase	329
646478254	475	26.04	38	471	2	416	2.0e-43	170	COG1721	Uncharacterized conserved protein, DUF58 family, contains vWF domain	416
646478255	341	31	8	329	4	289	8.0e-48	184	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646478256	667	45.85	29	643	1	586	0.0e+00	634	COG1331	Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains	667
646478257	268	28.36	6	267	5	262	2.0e-45	176	COG0300	Short-chain dehydrogenase	265
646478265	524	26.25	19	520	6	466	5.0e-53	202	COG2027	D-alanyl-D-alanine carboxypeptidase	470
646478266	382	41.64	4	364	2	365	8.0e-101	360	COG1060	2-iminoacetate synthase ThiH (tyrosine cleavage enzyme, thamine biosynthesis)	370
646478268	196	27.49	1	171	11	167	1.0e-23	103	COG0597	Lipoprotein signal peptidase	167
646478270	123	34.96	1	123	1	114	8.0e-14	69.3	COG1734	RNA polymerase-binding transcription factor DksA	120
646478271	150	26.9	1	141	1	138	3.0e-16	78	COG0394	Protein-tyrosine-phosphatase	139
646478272	1168	21.45	7	400	5	398	7.0e-13	70.4	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646478274	346	42.42	1	339	1	353	2.0e-72	266	COG4956	Uncharacterized conserved protein YacL, contains PIN and TRAM domains	356
646478275	401	34.49	40	398	8	410	1.0e-72	267	COG0232	dGTP triphosphohydrolase	412
646478276	695	40.95	59	627	1	560	2.0e-125	443	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
646478278	1062	23.93	40	350	27	332	1.0e-12	69.7	COG4447	Uncharacterized protein related to plant photosystem II stability/assembly factor	339
646478280	96	29.79	1	90	1	94	2.0e-10	57.3	COG1826	Sec-independent protein translocase protein TatA	94
646478283	266	36	1	245	2	248	2.0e-37	149	COG1354	Chromatin segregation and condensation protein Rec8/ScpA/Scc1, kleisin family	248
646478286	285	28.42	9	285	9	279	7.0e-47	180	COG3618	Predicted metal-dependent hydrolase, TIM-barrel fold	279
646478287	148	26.58	1	145	1	140	1.0e-12	65.7	COG4154	L-fucose mutarotase/ribose pyranase, RbsD/FucU family	144
646478288	272	25.84	20	272	12	274	1.0e-22	100	COG1082	Sugar phosphate isomerase/epimerase	274
646478289	373	26.68	2	370	12	392	4.0e-53	202	COG0246	Mannitol-1-phosphate/altronate dehydrogenases	473
646478290	342	34.19	1	339	1	349	3.0e-60	225	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
646478291	314	28.48	1	298	1	313	2.0e-44	173	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646478292	390	29.96	14	277	61	329	8.0e-28	118	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646478295	95	53.19	1	94	1	94	9.0e-25	104	COG0234	Co-chaperonin GroES (HSP10)	96
646478297	325	42.21	21	279	5	266	3.0e-73	268	COG3220	Uncharacterized conserved protein, UPF0276 family	282
646478301	256	49.78	7	235	6	233	2.0e-76	279	COG0052	Ribosomal protein S2	252
646478302	277	41.43	1	275	1	276	2.0e-63	235	COG0264	Translation elongation factor EF-Ts	296
646478303	255	54.2	10	246	2	237	2.0e-77	282	COG0528	Uridylate kinase	238
646478304	186	53.51	1	185	2	186	5.0e-54	203	COG0233	Ribosome recycling factor	187
646478305	310	34.23	48	288	6	257	2.0e-37	149	COG0584	Glycerophosphoryl diester phosphodiesterase	257
646478307	384	39.5	21	381	4	356	2.0e-85	309	COG1697	DNA topoisomerase VI, subunit A	356
646478314	151	29.14	1	150	1	134	2.0e-11	61.8	COG0848	Biopolymer transport protein ExbD	137
646478315	142	22.48	12	140	14	137	3.0e-10	57.9	COG0848	Biopolymer transport protein ExbD	137
646478316	300	28.57	70	278	10	213	2.0e-23	103	COG0811	Biopolymer transport protein ExbB/TolQ	216
646478321	300	26.67	18	300	4	231	2.0e-21	96.5	COG1018	Ferredoxin-NADP reductase	266
646478322	363	54.72	1	363	3	372	6.0e-130	457	COG0012	Ribosome-binding ATPase YchF, GTP1/OBG family	372
646478323	330	24.29	14	325	14	306	1.0e-37	150	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646478324	555	21.63	4	551	1	534	2.0e-48	187	COG2303	Choline dehydrogenase or related flavoprotein	542
646478331	177	33.33	31	147	3	116	9.0e-13	66.7	COG0517	CBS domain	117
646478332	366	41.18	1	365	2	346	2.0e-100	359	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
646478333	369	32.29	25	359	16	331	2.0e-50	193	COG1663	Tetraacyldisaccharide-1-P 4'-kinase	336
646478338	222	52.31	4	219	1	196	1.0e-75	275	COG0529	Adenylylsulfate kinase or related kinase	197
646478339	357	22.73	10	336	20	371	1.0e-19	90.6	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
646478340	559	21.76	30	537	45	570	7.0e-70	258	COG1164	Oligoendopeptidase F	598
646478341	241	34.08	20	240	19	234	5.0e-31	128	COG4089	Uncharacterized membrane protein	235
646478342	593	43.31	1	534	3	532	0.0e+00	461	COG1574	Predicted amidohydrolase YtcJ	535
646478343	222	14.08	13	210	1	205	1.0e-16	79.9	COG1335	Nicotinamidase-related amidase	205
646478345	325	24.71	1	323	1	314	1.0e-28	120	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646478346	261	32.34	1	257	1	251	5.0e-26	111	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646478347	418	50	255	405	1	158	3.0e-50	193	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
646478348	428	47.13	265	415	1	157	1.0e-48	187	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
646478350	203	38.19	1	192	2	184	5.0e-33	134	COG0742	16S rRNA G966 N2-methylase RsmD	187
646478351	316	25.69	59	272	30	220	1.0e-18	87.3	COG0284	Orotidine-5'-phosphate decarboxylase	240
646478355	261	42.73	26	244	4	223	2.0e-70	259	COG1136	ABC-type lipoprotein export system, ATPase component	226
646478357	244	21.51	6	191	5	188	3.0e-07	48.9	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646478360	412	32.37	8	410	1	387	5.0e-48	185	COG1680	CubicO group peptidase, beta-lactamase class C family	390
646478361	578	43.03	1	328	3	326	4.0e-79	289	COG1796	DNA polymerase/3'-5' exonuclease PolX	326
646478362	331	30.91	19	331	1	364	3.0e-59	222	COG1163	Ribosome-interacting GTPase 1	365
646478363	803	20.49	228	801	21	617	1.0e-30	129	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
646478368	244	40.17	11	239	3	223	7.0e-58	217	COG0325	Uncharacterized pyridoxal phosphate-containing protein, affects Ilv metabolism, UPF0001 family	228
646478369	102	36.96	9	98	11	102	5.0e-13	66.1	COG1872	Uncharacterized conserved protein YggU, UPF0235/DUF167 family	102
646478373	164	45.03	7	157	1	150	1.0e-36	145	COG0782	Transcription elongation factor, GreA/GreB family	151
646478379	517	32.44	270	513	1	259	4.0e-36	146	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	259
646478381	150	31.51	6	149	1	141	2.0e-18	85.4	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
646478382	154	38.95	53	146	3	97	2.0e-09	55.6	COG0640	DNA-binding transcriptional regulator, ArsR family	110
646478383	210	35.07	1	207	2	211	4.0e-34	137	COG2085	Predicted dinucleotide-binding enzyme	211
646478384	544	21.6	106	543	2	424	5.0e-36	146	COG1055	Na+/H+ antiporter NhaD or related arsenite permease	424
646478385	212	26.09	67	181	24	125	6.0e-08	51.1	COG0526	Thiol-disulfide isomerase or thioredoxin	127
646478386	272	33.19	19	244	18	241	4.0e-23	102	COG3000	Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily	271
646478387	229	42.53	1	219	3	222	1.0e-64	239	COG0603	7-cyano-7-deazaguanine synthase (queuosine biosynthesis)	222
646478388	400	43.7	1	389	2	379	4.0e-109	388	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
646478389	398	29.51	23	387	85	407	4.0e-47	182	COG0593	Chromosomal replication initiation ATPase DnaA	408
646478391	372	25.95	1	368	1	362	2.0e-42	166	COG0592	DNA polymerase III sliding clamp (beta) subunit, PCNA homolog	364
646478393	830	59.33	9	567	1	556	0.0e+00	782	COG0187	DNA gyrase/topoisomerase IV, subunit B	635
646478395	709	32.66	513	706	9	202	1.0e-22	101	COG0400	Predicted esterase	207
646478397	522	43.44	38	519	1	485	0.0e+00	471	COG0260	Leucyl aminopeptidase	485
646478398	607	35.5	1	456	3	440	6.0e-99	355	COG0043	3-polyprenyl-4-hydroxybenzoate decarboxylase	477
646478399	719	37.36	542	719	32	205	7.0e-38	152	COG1611	Predicted Rossmann fold nucleotide-binding protein	205
646478400	259	36.76	14	254	6	251	4.0e-28	118	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646478401	187	35.06	31	182	1	149	1.0e-37	149	COG2731	Beta-galactosidase, beta subunit	154
646478403	1129	25.19	4	1068	1	1005	0.0e+00	543	COG0841	Multidrug efflux pump subunit AcrB	1009
646478404	221	33.64	1	215	2	218	7.0e-34	137	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
646478405	189	20.29	34	164	21	136	4.0e-07	47.9	COG1943	REP element-mobilizing transposase RayT	136
646478406	284	38.68	3	282	3	279	5.0e-54	204	COG0287	Prephenate dehydrogenase	279
646478407	981	37.1	179	976	1	742	0.0e+00	613	COG0046	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain	743
646478408	254	39.69	1	254	1	231	3.0e-60	225	COG0047	Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain	231
646478415	363	50.84	4	360	2	355	2.0e-115	409	COG0337	3-dehydroquinate synthetase	360
646478416	309	27.65	68	309	13	273	1.0e-20	94.1	COG1082	Sugar phosphate isomerase/epimerase	274
646478417	134	34.82	15	126	1	111	2.0e-25	108	COG0799	Ribosomal silencing factor RsfS, regulates association of 30S and 50S subunits	115
646478418	401	36.13	20	401	10	350	3.0e-81	295	COG0758	Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake	350
646478419	209	49.23	5	199	4	198	4.0e-53	201	COG4566	Two-component response regulator, FixJ family, consists of REC and HTH domains	202
646478421	409	41.42	34	409	21	396	8.0e-97	347	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
646478423	541	21.41	32	475	6	454	3.0e-12	67	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
646478425	300	26.72	51	297	61	306	7.0e-29	121	COG4965	Flp pilus assembly protein TadB	309
646478426	476	51.41	57	410	7	355	3.0e-103	369	COG4962	Pilus assembly protein, ATPase of CpaF family	355
646478428	330	25.94	15	247	12	239	5.0e-10	58.8	COG3745	Flp pilus assembly protein CpaB	276
646478445	613	56	7	613	4	619	0.0e+00	861	COG0445	tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA	621
646478449	532	43.42	52	525	20	484	6.0e-117	415	COG0606	Predicted ATPase with chaperone activity	490
646478452	236	20	2	220	8	222	2.0e-09	56.2	COG4912	3-methyladenine DNA glycosylase AlkD	222
646478453	306	27.06	4	303	1	297	7.0e-25	108	COG0583	DNA-binding transcriptional regulator, LysR family	297
646478455	961	30.96	169	475	1	279	4.0e-40	160	COG0515	Serine/threonine protein kinase	384
646478459	349	32.93	22	342	3	330	4.0e-60	225	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
646478469	733	30.01	31	722	7	704	0.0e+00	575	COG0058	Glucan phosphorylase	750
646478470	165	34.68	1	124	1	124	3.0e-20	91.4	COG3030	Protein affecting phage T7 exclusion by the F plasmid, UPF0716 family	158
646478473	387	44.94	31	386	1	346	1.0e-98	353	COG2706	6-phosphogluconolactonase, cycloisomerase 2 family	346
646478480	835	37.95	37	480	1	454	1.0e-101	364	COG0286	Type I restriction-modification system, DNA methylase subunit	489
646478481	421	22.83	79	417	56	391	3.0e-23	103	COG0732	Restriction endonuclease S subunit	391
646478483	1020	23.82	7	997	3	957	7.0e-116	412	COG0610	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases ...	962
646478484	238	30.23	15	229	16	216	2.0e-28	119	COG1451	Predicted metal-dependent hydrolase	223
646478485	942	25.47	625	940	15	325	3.0e-31	130	COG1518	CRISPR/Cas system-associated endonuclease Cas1	327
646478486	90	34.78	3	69	2	70	6.0e-06	42.5	COG1343	CRISPR/Cas system-associated endoribonuclease Cas2	89
646478490	1272	21.46	10	227	4	212	2.0e-13	72.3	COG1337	CRISPR/Cas system CSM-associated protein Csm3, group 7 of RAMP superfamily	249
646478494	268	29.17	8	99	1	96	3.0e-10	59	COG3293	Transposase	124
646478510	486	28.91	25	422	1	443	5.0e-60	225	COG3119	Arylsulfatase A or related enzyme	475
646478512	177	26.74	1	169	6	177	8.0e-14	70.1	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646478514	676	31.33	52	477	4	459	3.0e-55	209	COG3119	Arylsulfatase A or related enzyme	475
646478518	468	28.22	29	432	4	440	3.0e-47	183	COG3119	Arylsulfatase A or related enzyme	475
646478522	293	36.11	12	286	10	293	7.0e-43	167	COG2040	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)	300
646478525	188	33.33	4	175	4	176	2.0e-21	95.5	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646478526	161	57.75	20	161	41	182	2.0e-41	161	COG2335	Uncaracterized surface protein containing fasciclin (FAS1) repeats	187
646478527	675	29.79	401	652	29	310	2.0e-38	154	COG1262	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain	314
646478530	684	28.45	143	622	12	429	1.0e-49	191	COG4964	Flp pilus assembly protein, secretin CpaC	455
646478531	139	27.68	10	112	10	121	1.0e-12	65.7	COG1430	Uncharacterized conserved membrane protein, UPF0127 family	126
646478533	289	22.61	60	289	82	309	3.0e-20	92.3	COG4965	Flp pilus assembly protein TadB	309
646478534	490	53.67	94	447	7	355	2.0e-104	373	COG4962	Pilus assembly protein, ATPase of CpaF family	355
646478536	487	17.07	12	166	17	170	4.0e-07	49.7	COG4961	Flp pilus assembly protein TadG	185
646478541	223	38.05	11	215	2	203	3.0e-41	162	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646478542	1238	41.85	255	521	1	268	3.0e-71	264	COG1352	Methylase of chemotaxis methyl-accepting proteins	268
646478545	140	35.34	2	117	3	114	2.0e-18	84.6	COG5609	Uncharacterized protein YbcI	124
646478550	615	32.16	18	559	34	588	3.0e-87	316	COG0296	1,4-alpha-glucan branching enzyme	628
646478553	593	31.15	8	291	2	299	2.0e-43	171	COG0003	Anion-transporting ATPase, ArsA/GET3 family	322
646478555	112	40.7	24	109	9	94	8.0e-09	52.5	COG0640	DNA-binding transcriptional regulator, ArsR family	110
646478556	827	41.59	105	820	24	711	0.0e+00	606	COG2217	Cation transport ATPase	713
646478560	206	35	137	196	5	64	2.0e-08	52.7	COG2771	DNA-binding transcriptional regulator, CsgD family	65
646478561	1048	21.66	32	387	61	398	4.0e-10	61.2	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646478565	1099	25.98	6	1074	5	1009	0.0e+00	574	COG0841	Multidrug efflux pump subunit AcrB	1009
646478566	616	23.68	189	606	45	444	4.0e-23	103	COG1538	Outer membrane protein TolC	457
646478568	476	22.67	89	464	43	438	2.0e-26	114	COG1538	Outer membrane protein TolC	457
646478569	380	19.61	9	380	11	408	2.0e-21	97.3	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
646478570	241	49.56	3	227	1	226	2.0e-70	259	COG1136	ABC-type lipoprotein export system, ATPase component	226
646478572	389	17.63	7	387	5	406	4.0e-11	63	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
646478577	430	22.22	15	373	8	358	2.0e-11	64.2	COG4102	Uncharacterized conserved protein, DUF1501 family	418
646478578	339	22.66	11	336	51	401	5.0e-23	102	COG2319	WD40 repeat	466
646478581	443	21.57	55	443	67	443	2.0e-12	67.9	COG2271	Sugar phosphate permease	448
646478583	413	28.75	6	399	2	388	5.0e-44	172	COG2942	Mannose or cellobiose epimerase, N-acyl-D-glucosamine 2-epimerase family	388
646478586	453	22.25	5	447	2	444	3.0e-18	86.9	COG1232	Protoporphyrinogen oxidase	444
646478588	942	42.25	32	942	9	910	0.0e+00	793	COG2352	Phosphoenolpyruvate carboxylase	910
646478592	927	40.39	19	913	22	911	0.0e+00	786	COG0474	Magnesium-transporting ATPase (P-type)	917
646478593	93	41.49	1	91	2	88	2.0e-15	74.3	COG3809	Predicted nucleic acid-binding protein, contains Zn-finger domain	88
646478594	530	17.32	2	288	8	313	1.0e-16	82.2	COG0701	Uncharacterized membrane protein YraQ, UPF0718 family	317
646478597	576	34.15	251	574	1	302	1.0e-49	191	COG0492	Thioredoxin reductase	305
646478598	436	25.29	7	430	5	384	2.0e-36	147	COG0006	Xaa-Pro aminopeptidase	384
646478600	417	28.04	1	415	1	380	6.0e-42	165	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
646478601	312	34.24	1	311	4	333	3.0e-77	282	COG3938	Proline racemase	341
646478602	302	38.03	6	287	5	288	2.0e-67	249	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646478605	243	36.61	132	243	13	124	1.0e-19	90.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646478609	220	38.71	28	213	1	177	1.0e-27	116	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646478610	329	36.97	22	300	1	266	2.0e-58	219	COG2041	Periplasmic DMSO/TMAO reductase YedYZ, molybdopterin-dependent catalytic subunit	271
646478611	585	31.65	229	525	7	266	8.0e-51	195	COG1018	Ferredoxin-NADP reductase	266
646478613	146	29.66	20	137	9	126	2.0e-10	58.4	COG1846	DNA-binding transcriptional regulator, MarR family	126
646478614	636	18.06	264	541	6	275	1.0e-10	61.8	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646478618	541	27.63	68	494	33	447	8.0e-53	201	COG1538	Outer membrane protein TolC	457
646478619	1062	47.53	1	1030	1	1009	0.0e+00	984	COG0841	Multidrug efflux pump subunit AcrB	1009
646478620	470	31.65	64	414	39	368	4.0e-30	126	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646478621	357	35.15	25	353	13	337	1.0e-93	336	COG0208	Ribonucleotide reductase beta subunit, ferritin-like domain	348
646478622	945	37.17	187	902	23	649	0.0e+00	553	COG0209	Ribonucleotide reductase alpha subunit	696
646478627	146	26.83	1	123	1	123	4.0e-14	70.7	COG3682	Predicted transcriptional regulator	123
646478628	687	18.3	9	383	3	332	2.0e-11	64.6	COG4219	Signal transducer regulating beta-lactamase production, contains  metallopeptidase domain	337
646478632	398	28.44	9	340	2	306	2.0e-47	183	COG0673	Predicted dehydrogenase	342
646478634	242	49.41	1	241	1	245	9.0e-82	296	COG4422	Bacteriophage protein gp37	250
646478637	481	29.47	1	456	8	442	2.0e-52	199	COG3119	Arylsulfatase A or related enzyme	475
646478638	268	30.21	8	99	1	96	1.0e-10	60.5	COG3293	Transposase	124
646478640	268	30.21	8	99	1	96	1.0e-10	60.1	COG3293	Transposase	124
646478646	268	30.21	8	99	1	96	1.0e-10	60.5	COG3293	Transposase	124
646478649	465	37.28	5	457	4	454	6.0e-124	438	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
646478651	1215	33.25	1	1188	2	1158	0.0e+00	562	COG1196	Chromosome segregation ATPase	1163
646478652	639	33.92	106	634	189	752	6.0e-75	275	COG1112	Superfamily I DNA and/or RNA helicase	767
646478653	824	38.86	480	806	2	331	7.0e-65	242	COG3380	Predicted NAD/FAD-dependent oxidoreductase	331
646478655	264	70.68	1	264	3	268	1.0e-118	419	COG0207	Thymidylate synthase	268
646478656	171	40.48	10	169	1	167	3.0e-35	141	COG0262	Dihydrofolate reductase	167
646478657	518	27.55	9	356	14	371	4.0e-34	139	COG1680	CubicO group peptidase, beta-lactamase class C family	390
646478659	129	32.12	7	125	4	139	1.0e-19	88.5	COG0822	NifU homolog involved in Fe-S cluster formation	150
646478660	422	52.7	7	412	1	405	0.0e+00	480	COG0520	Selenocysteine lyase/Cysteine desulfurase	405
646478663	308	37.13	1	305	4	293	4.0e-68	251	COG1131	ABC-type multidrug transport system, ATPase component	293
646478666	652	44.29	78	637	1	528	0.0e+00	675	COG0365	Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase	528
646478668	490	29.29	30	483	1	458	6.0e-60	225	COG3119	Arylsulfatase A or related enzyme	475
646478669	468	31.85	27	410	2	443	5.0e-63	235	COG3119	Arylsulfatase A or related enzyme	475
646478671	226	45.33	3	225	1	225	4.0e-60	224	COG2738	Zn-dependent membrane protease YugP	226
646478673	580	36.2	6	570	5	506	7.0e-116	411	COG0155	Sulfite reductase, beta subunit (hemoprotein)	510
646478677	396	65.37	5	390	4	387	0.0e+00	614	COG0192	S-adenosylmethionine synthetase	388
646478679	352	23.35	63	307	13	256	3.0e-07	49.5	COG0428	Zinc transporter ZupT	266
646478680	339	22.36	12	324	7	296	3.0e-18	86.5	COG4972	Tfp pilus assembly protein, ATPase PilM	354
646478683	389	27.15	17	166	4	148	2.0e-08	53.9	COG2165	Type II secretory pathway, pseudopilin PulG	149
646478684	624	50.96	1	624	1	597	0.0e+00	757	COG0449	Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains	597
646478689	534	24.08	1	480	6	510	4.0e-30	126	COG2268	Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain	548
646478691	267	53.23	7	265	1	263	1.0e-94	339	COG0413	Ketopantoate hydroxymethyltransferase	268
646478692	598	28.68	51	591	10	515	3.0e-60	226	COG0815	Apolipoprotein N-acyltransferase	518
646478697	257	34.18	22	256	11	238	2.0e-34	139	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
646478698	307	21.4	38	301	10	258	3.0e-22	99.3	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	259
646478699	938	48.83	20	912	3	804	0.0e+00	905	COG0188	DNA gyrase/topoisomerase IV, subunit A	804
646478700	436	53.94	1	418	1	414	0.0e+00	538	COG1004	UDP-glucose 6-dehydrogenase	414
646478702	361	20.43	172	356	46	218	6.0e-13	68.8	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
646478708	268	30.21	8	99	1	96	1.0e-10	60.5	COG3293	Transposase	124
646478710	598	40.04	1	492	29	509	5.0e-123	435	COG0513	Superfamily II DNA and RNA helicase	513
646478712	149	28.97	13	149	16	148	5.0e-10	57	COG3832	Uncharacterized conserved protein YndB, AHSA1/START domain	149
646478715	264	27.5	1	196	7	197	4.0e-20	92.1	COG2120	N-acetylglucosaminyl deacetylase, LmbE family	237
646478716	304	28.48	1	302	6	289	1.0e-22	100	COG0382	4-hydroxybenzoate polyprenyltransferase	289
646478717	347	29.97	1	341	7	307	9.0e-38	151	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646478718	203	30.05	1	183	1	176	6.0e-31	127	COG0279	Phosphoheptose isomerase	176
646478720	451	65.36	1	431	2	431	0.0e+00	682	COG0422	Thiamine biosynthesis protein ThiC	432
646478729	416	38.16	2	409	1	410	5.0e-78	285	COG2195	Di- or tripeptidase	414
646478739	1198	32.49	664	1198	6	533	8.0e-76	279	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646478741	110	29.47	11	100	2	96	2.0e-11	61.1	COG2329	Heme-degrading monooxygenase HmoA and related ABM domain proteins	105
646478742	157	61.44	5	157	4	156	3.0e-57	213	COG1225	Peroxiredoxin	157
646478743	394	36.6	51	393	2	308	3.0e-64	239	COG2017	Galactose mutarotase or related enzyme	308
646478744	204	32.5	36	195	20	176	2.0e-16	79	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646478748	940	30.21	480	905	42	431	2.0e-43	171	COG4964	Flp pilus assembly protein, secretin CpaC	455
646478750	798	18.87	6	396	15	431	9.0e-15	76.1	COG1904	Glucuronate isomerase	463
646478755	229	24.03	47	189	34	186	1.0e-09	57	COG2020	Protein-S-isoprenylcysteine O-methyltransferase Ste14	187
646478758	293	26.39	24	291	2	283	5.0e-26	111	COG0515	Serine/threonine protein kinase	384
646478759	278	56.88	6	274	12	279	6.0e-102	363	COG0777	Acetyl-CoA carboxylase beta subunit	294
646478760	193	28.72	1	193	2	196	8.0e-24	103	COG0406	Broad specificity phosphatase PhoE	208
646478761	229	46.01	19	229	8	220	1.0e-65	243	COG0036	Pentose-5-phosphate-3-epimerase	220
646478762	693	18.51	57	562	28	489	4.0e-15	76.9	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
646478764	419	48.4	1	403	3	383	0.0e+00	471	COG0448	ADP-glucose pyrophosphorylase	393
646478765	647	31.2	1	590	1	489	7.0e-96	345	COG0367	Asparagine synthetase B (glutamine-hydrolyzing)	542
646478772	1461	21.94	39	259	6	239	3.0e-14	75.5	COG3828	Type 1 glutamine amidotransferase (GATase1)-like domain	239
646478773	329	31.51	92	323	84	320	4.0e-18	85.6	COG2064	Pilus assembly protein TadC	320
646478774	321	33.9	86	321	74	309	2.0e-43	170	COG4965	Flp pilus assembly protein TadB	309
646478775	440	51.26	42	398	4	355	3.0e-114	405	COG4962	Pilus assembly protein, ATPase of CpaF family	355
646478776	274	24.49	25	265	3	235	2.0e-19	90.2	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646478777	412	35.8	19	355	8	339	4.0e-73	268	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
646478778	338	25.59	7	331	3	342	1.0e-47	183	COG0673	Predicted dehydrogenase	342
646478780	465	24.51	10	439	2	444	9.0e-45	175	COG1232	Protoporphyrinogen oxidase	444
646478782	396	45.58	5	374	4	373	7.0e-108	384	COG0381	UDP-N-acetylglucosamine 2-epimerase	383
646478783	510	46.12	281	510	9	226	4.0e-65	242	COG2148	Sugar transferase involved in LPS biosynthesis (colanic, teichoic acid)	226
646478786	489	25.76	19	445	11	410	4.0e-17	83.2	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
646478788	402	26.58	36	400	13	381	7.0e-35	141	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646478792	242	39.67	1	239	6	240	1.0e-62	232	COG0217	Transcriptional and/or translational regulatory protein YebC/TACO1	241
646478794	261	37.7	4	246	2	236	7.0e-44	170	COG2188	DNA-binding transcriptional regulator, GntR family	236
646478795	264	39.27	1	246	1	228	1.0e-53	203	COG0274	Deoxyribose-phosphate aldolase	228
646478796	976	21.1	4	420	2	396	4.0e-06	47.7	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646478797	545	27.85	26	415	3	430	2.0e-36	147	COG3119	Arylsulfatase A or related enzyme	475
646478800	495	30.37	37	454	1	443	1.0e-50	194	COG3119	Arylsulfatase A or related enzyme	475
646478805	345	20.42	65	280	82	302	5.0e-13	68.8	COG0501	Zn-dependent protease with chaperone function	302
646478811	459	27.06	7	446	4	441	2.0e-41	163	COG0038	H+/Cl- antiporter ClcA	443
646478813	521	43.54	52	405	18	341	2.0e-69	257	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646478814	503	20.67	171	451	79	350	2.0e-06	47.5	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646478820	331	46.27	1	327	1	321	1.0e-90	326	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
646478822	357	30.91	217	326	18	124	2.0e-07	50.7	COG0526	Thiol-disulfide isomerase or thioredoxin	127
646478823	963	31.03	390	505	18	127	1.0e-09	59.5	COG0526	Thiol-disulfide isomerase or thioredoxin	127
646478824	115	44.21	4	96	2	96	3.0e-17	80.7	COG2154	Pterin-4a-carbinolamine dehydratase	101
646478840	666	52.43	34	651	1	589	0.0e+00	719	COG0441	Threonyl-tRNA synthetase	589
646478841	353	22.08	47	346	1	294	2.0e-23	103	COG1840	ABC-type Fe3+ transport system, periplasmic component	299
646478844	186	31.9	31	146	7	120	3.0e-09	55.3	COG1846	DNA-binding transcriptional regulator, MarR family	126
646478846	555	23.23	127	555	17	426	3.0e-31	130	COG3746	Phosphate-selective porin	426
646478851	339	21.5	2	317	6	285	1.0e-16	81.1	COG0657	Acetyl esterase/lipase	312
646478852	454	22.28	63	444	40	442	2.0e-25	110	COG1538	Outer membrane protein TolC	457
646478854	181	40.65	28	181	5	159	3.0e-24	104	COG3476	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	161
646478858	274	31.46	1	264	9	269	4.0e-28	118	COG3267	Type II secretory pathway, component ExeA (predicted ATPase)	269
646478859	622	24.77	408	614	15	227	4.0e-12	67	COG0489	Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster	265
646478861	1234	55.07	335	1200	2	842	0.0e+00	1065	COG1410	Methionine synthase I, cobalamin-binding domain	842
646478862	399	31.08	31	280	23	233	8.0e-38	151	COG0861	Membrane protein TerC, possibly involved in tellurium resistance	254
646478866	338	18.6	69	304	11	268	7.0e-08	51.8	COG1082	Sugar phosphate isomerase/epimerase	274
646478867	1095	68.1	13	407	1	393	0.0e+00	561	COG0458	Carbamoylphosphate synthase large subunit	400
646478872	340	25	21	168	6	149	4.0e-09	55.8	COG2165	Type II secretory pathway, pseudopilin PulG	149
646478876	101	39.33	5	93	4	92	7.0e-15	72.2	COG3326	Uncharacterized membrane protein YsdA, DUF1294 family	94
646478877	332	26.28	7	316	7	271	2.0e-29	123	COG1082	Sugar phosphate isomerase/epimerase	274
646478878	200	49.39	40	200	10	173	1.0e-48	186	COG0290	Translation initiation factor IF-3	176
646478886	311	28.57	3	295	1	284	3.0e-32	132	COG0115	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase	284
646478888	101	23.38	22	97	23	99	7.0e-07	45.6	COG3162	Uncharacterized membrane protein, DUF485 family	102
646478892	732	21.53	20	420	5	395	5.0e-20	93.6	COG1668	ABC-type Na+ efflux pump, permease component	407
646478893	251	42.21	1	243	4	244	1.0e-63	236	COG1131	ABC-type multidrug transport system, ATPase component	293
646478894	274	21.43	2	246	1	251	1.0e-05	44.2	COG0730	Uncharacterized membrane protein YfcA	258
646478895	543	57.25	29	538	21	527	0.0e+00	718	COG1866	Phosphoenolpyruvate carboxykinase, ATP-dependent	529
646478899	340	42.34	12	335	6	329	4.0e-72	265	COG0714	MoxR-like ATPase	329
646478909	431	37.21	1	253	2	253	7.0e-50	191	COG0631	Serine/threonine protein phosphatase PrpC	262
646478911	147	56.64	4	144	1	143	5.0e-44	170	COG0102	Ribosomal protein L13	148
646478912	137	50.41	15	137	8	130	3.0e-35	140	COG0103	Ribosomal protein S9	130
646478915	350	20.57	46	316	31	294	2.0e-10	59.9	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646478916	123	22.22	8	106	3	92	4.0e-06	43.8	COG1694	NTP pyrophosphatase, house-cleaning of non-canonical NTPs	102
646478917	2373	56.51	6	1002	6	933	0.0e+00	1357	COG0178	Excinuclease UvrABC ATPase subunit	935
646478919	250	24.43	17	235	4	215	2.0e-18	86.1	COG0398	Uncharacterized membrane protein YdjX, TVP38/TMEM64 family, SNARE-associated domain	223
646478920	391	23.14	17	364	8	343	1.0e-24	107	COG1721	Uncharacterized conserved protein, DUF58 family, contains vWF domain	416
646478921	322	43.96	11	322	8	329	6.0e-69	254	COG0714	MoxR-like ATPase	329
646478922	152	27.36	39	144	18	122	3.0e-06	44.5	COG1846	DNA-binding transcriptional regulator, MarR family	126
646478923	179	32.48	36	144	9	123	9.0e-07	46.9	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
646478924	335	28.61	8	332	1	325	2.0e-45	176	COG0604	NADPH:quinone reductase or related Zn-dependent oxidoreductase	326
646478928	588	43.55	1	573	2	568	0.0e+00	560	COG1080	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria)	574
646478929	160	34.4	3	126	19	138	1.0e-18	86.1	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
646478930	130	45.9	4	64	2	62	1.0e-08	52.2	COG0236	Acyl carrier protein	80
646478931	202	33.87	6	126	22	145	1.0e-16	80.3	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
646478932	428	47.78	1	426	1	411	9.0e-123	433	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646478936	162	31.79	1	139	3	153	6.0e-17	80.4	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
646478937	483	48.9	8	446	6	457	0.0e+00	462	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646478939	1510	35.88	1	888	3	788	0.0e+00	696	COG1201	Lhr-like helicase	814
646478941	88	51.76	1	85	1	82	4.0e-07	46.6	COG2261	Uncharacterized membrane protein YeaQ/YmgE, transglycosylase-associated protein family	82
646478942	686	53.37	6	686	1	662	0.0e+00	913	COG0021	Transketolase	663
646478945	427	20.31	13	369	7	358	2.0e-08	53.8	COG4102	Uncharacterized conserved protein, DUF1501 family	418
646478947	402	29.44	16	396	6	383	7.0e-47	181	COG1680	CubicO group peptidase, beta-lactamase class C family	390
646478948	313	36.45	16	313	7	304	4.0e-50	192	COG3118	Negative regulator of GroEL, contains thioredoxin-like and TPR-like domains	304
646478954	193	36.53	5	171	1	156	2.0e-25	108	COG0431	NAD(P)H-dependent FMN reductase	184
646478955	161	38.85	2	158	1	156	6.0e-37	146	COG0783	DNA-binding ferritin-like protein (oxidative damage protectant)	156
646478956	143	32.12	1	137	7	139	6.0e-12	63.5	COG2259	Uncharacterized membrane protein YphA, DoxX/SURF4 family	142
646478957	242	40.55	1	242	1	243	1.0e-44	173	COG1741	Redox-sensitive bicupin YhaK, pirin superfamily	276
646478958	164	38.94	34	146	7	118	5.0e-09	54.2	COG1846	DNA-binding transcriptional regulator, MarR family	126
646478959	464	29.81	26	449	5	426	1.0e-74	274	COG1029	Formylmethanofuran dehydrogenase subunit B	429
646478961	556	36.51	3	428	1	415	6.0e-59	222	COG0446	NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase	415
646478962	458	41.18	5	457	22	479	4.0e-121	428	COG0513	Superfamily II DNA and RNA helicase	513
646478965	954	41.08	1	952	2	814	0.0e+00	841	COG0495	Leucyl-tRNA synthetase	814
646478966	290	43.03	25	273	6	251	1.0e-77	283	COG0024	Methionine aminopeptidase	255
646478968	253	22.71	5	253	4	291	3.0e-20	92.4	COG1234	Ribonuclease BN, tRNA processing enzyme	292
646478970	422	40.28	126	408	6	283	1.0e-83	303	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	283
646478971	313	28.52	1	298	5	247	6.0e-44	171	COG3496	Uncharacterized conserved protein, DUF1365 family	261
646478972	432	41.63	1	413	9	425	5.0e-112	398	COG2907	Predicted NAD/FAD-binding protein	447
646478973	465	42.24	163	465	1	296	1.0e-87	317	COG1090	NAD dependent epimerase/dehydratase family enzyme	297
646478974	374	30.48	160	361	62	329	2.0e-24	106	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
646478975	313	18.28	86	264	24	205	3.0e-09	56.4	COG5012	Methanogenic corrinoid protein MtbC1	227
646478976	448	20.07	102	372	24	284	2.0e-08	54.5	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646478979	419	31.9	5	416	3	407	3.0e-65	242	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646478981	768	26.02	61	613	2	484	5.0e-48	186	COG1032	Radical SAM superfamily enzyme YgiQ, UPF0313 family	490
646478982	368	29.2	1	368	1	379	9.0e-35	141	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646478983	393	21.48	4	387	1	378	3.0e-23	103	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646478984	175	48.24	2	169	9	178	1.0e-46	179	COG0634	Hypoxanthine-guanine phosphoribosyltransferase	178
646478985	265	18.86	37	260	44	315	1.0e-07	50.8	COG0627	S-formylglutathione hydrolase FrmB	316
646478986	190	25	21	148	1	135	8.0e-08	50.6	COG1225	Peroxiredoxin	157
646478987	224	28.95	66	179	19	126	3.0e-07	49.1	COG0526	Thiol-disulfide isomerase or thioredoxin	127
646478989	677	25.99	7	270	28	303	3.0e-23	103	COG2367	Beta-lactamase class A	329
646478992	436	18.31	104	432	36	352	7.0e-12	65.6	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646478994	378	50.26	2	378	1	379	4.0e-121	428	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
646478999	141	27.54	1	138	5	137	8.0e-24	103	COG0824	Acyl-CoA thioesterase FadM	137
646479000	456	22.6	12	398	6	358	1.0e-05	45	COG4102	Uncharacterized conserved protein, DUF1501 family	418
646479006	441	52.63	6	439	2	436	0.0e+00	549	COG2256	Replication-associated recombination protein RarA (DNA-dependent ATPase)	436
646479009	440	41.92	1	421	1	426	8.0e-114	403	COG0044	Dihydroorotase or related cyclic amidohydrolase	430
646479012	263	26.2	20	241	20	237	1.0e-25	110	COG1402	 Creatinine amidohydrolase/Fe(II)-dependent formamide hydrolase involved in riboflavin and F420 biosynthesis	250
646479013	428	36.79	31	428	7	393	5.0e-89	321	COG1092	23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI	393
646479014	251	30.54	8	246	2	215	9.0e-21	93.9	COG1411	Uncharacterized protein related to proFAR isomerase (HisA)	229
646479019	757	24.35	95	460	23	363	5.0e-15	76.8	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646479027	325	18.58	11	305	4	286	2.0e-11	63.2	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
646479030	411	25.65	1	405	13	431	8.0e-55	208	COG0612	Predicted Zn-dependent peptidase	438
646479032	128	40	1	115	1	112	1.0e-19	88.4	COG5609	Uncharacterized protein YbcI	124
646479034	157	26.36	1	110	1	110	2.0e-07	49.1	COG5609	Uncharacterized protein YbcI	124
646479042	171	27.45	3	154	2	152	8.0e-23	99	COG1047	FKBP-type peptidyl-prolyl cis-trans isomerase 2	174
646479043	410	22.31	7	378	5	377	2.0e-22	100	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646479045	335	45.79	12	321	1	313	2.0e-88	319	COG2152	Predicted glycosyl hydrolase, GH43/DUF377 family	314
646479046	336	27.94	43	271	42	298	1.0e-18	87.7	COG4188	Predicted dienelactone hydrolase	365
646479048	243	31.78	16	229	10	220	2.0e-27	116	COG4912	3-methyladenine DNA glycosylase AlkD	222
646479050	358	44.94	15	192	6	183	2.0e-43	170	COG2169	Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains	187
646479053	294	58.17	22	284	8	259	4.0e-91	327	COG2022	Thiamin biosynthesis thiazole synthase ThiGH, ThiG subunit	262
646479054	67	50.75	1	67	2	68	9.0e-15	71.8	COG2104	Sulfur carrier protein ThiS (thiamine biosynthesis)	68
646479059	427	19.86	31	423	1	420	4.0e-22	99.6	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
646479061	107	31.53	4	105	2	111	4.0e-08	50	COG2337	mRNA-degrading endonuclease, toxin component of the MazEF toxin-antitoxin module	112
646479062	317	22.38	58	314	55	293	7.0e-12	65.1	COG2159	Predicted metal-dependent hydrolase, TIM-barrel fold	293
646479067	61	53.57	1	56	1	56	1.0e-09	54.5	COG0333	Ribosomal protein L32	57
646479068	306	48.31	5	300	2	294	1.0e-82	300	COG0331	Malonyl CoA-acyl carrier protein transacylase	310
646479069	256	48.62	12	255	2	251	8.0e-51	193	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646479070	95	38.46	13	90	2	75	3.0e-10	56.4	COG0238	Ribosomal protein S18	75
646479071	143	31.43	1	140	2	137	1.0e-22	99.2	COG0824	Acyl-CoA thioesterase FadM	137
646479073	225	47.27	4	222	2	221	4.0e-70	257	COG1136	ABC-type lipoprotein export system, ATPase component	226
646479074	1184	17.86	802	1184	1	419	4.0e-09	57.8	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
646479076	154	27.86	13	152	9	137	5.0e-23	100	COG0824	Acyl-CoA thioesterase FadM	137
646479077	249	55.75	3	227	1	226	4.0e-80	291	COG1136	ABC-type lipoprotein export system, ATPase component	226
646479078	840	24.16	18	383	26	406	1.0e-25	112	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
646479079	267	21.88	36	234	10	228	2.0e-18	86.6	COG0775	Nucleoside phosphorylase	234
646479080	388	26.06	21	311	12	309	1.0e-25	110	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
646479081	724	30.28	135	696	13	515	8.0e-66	245	COG1657	Squalene cyclase	517
646479082	209	27.78	2	180	8	177	7.0e-12	64.3	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646479083	252	42.13	3	250	1	251	7.0e-47	180	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646479084	437	20.14	108	374	42	304	2.0e-11	63.7	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646479086	255	71.37	1	255	1	255	2.0e-112	398	COG0107	Imidazole glycerol phosphate synthase subunit HisF	256
646479087	395	44.66	31	386	2	353	2.0e-103	369	COG2805	Tfp pilus assembly protein PilT, pilus retraction ATPase	353
646479088	607	27.25	179	607	104	500	9.0e-46	178	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646479091	251	26.67	3	239	5	232	2.0e-28	119	COG1381	Recombinational DNA repair protein (RecF pathway)	251
646479095	298	45.86	18	282	2	263	4.0e-67	248	COG0294	Dihydropteroate synthase	274
646479096	727	56.09	1	727	1	724	0.0e+00	978	COG3968	Glutamine synthetase type III	724
646479097	470	44.21	1	469	1	442	0.0e+00	489	COG0174	Glutamine synthetase	443
646479098	247	25.59	5	214	5	195	1.0e-15	76.8	COG0684	Regulator of RNase E activity RraA	210
646479100	299	25.19	34	299	16	281	3.0e-20	92.8	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646479102	453	34	9	452	13	462	1.0e-81	297	COG1109	Phosphomannomutase	464
646479105	493	25.86	24	456	3	435	1.0e-53	204	COG0544	FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor)	441
646479106	208	55.19	16	198	10	192	4.0e-62	230	COG0740	ATP-dependent protease ClpP, protease subunit	200
646479107	205	66.15	1	192	1	192	4.0e-76	277	COG0740	ATP-dependent protease ClpP, protease subunit	200
646479108	226	34.67	1	223	1	223	2.0e-32	132	COG1802	DNA-binding transcriptional regulator, GntR family	230
646479109	109	37.14	1	104	1	96	1.0e-15	75	COG3536	Uncharacterized conserved protein, DUF971 family	120
646479110	292	39.01	6	283	12	288	3.0e-62	232	COG0685	5,10-methylenetetrahydrofolate reductase	291
646479112	975	17.29	34	316	2	278	7.0e-14	73.2	COG1277	ABC-type transport system involved in multi-copper enzyme maturation, permease component	278
646479113	240	40.27	1	218	4	224	4.0e-64	237	COG1131	ABC-type multidrug transport system, ATPase component	293
646479115	319	54.22	8	314	1	300	2.0e-112	399	COG0031	Cysteine synthase	300
646479118	304	26.99	32	297	9	291	8.0e-34	137	COG3386	Sugar lactone lactonase YvrE	307
646479119	903	29.2	717	845	10	143	4.0e-17	84.1	COG1225	Peroxiredoxin	157
646479120	329	26.79	10	328	132	448	1.0e-43	170	COG2239	Mg/Co/Ni transporter MgtE (contains CBS domain)	451
646479123	596	45.93	20	594	1	550	0.0e+00	614	COG0028	Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme	550
646479124	347	36.58	42	332	1	275	9.0e-46	177	COG3386	Sugar lactone lactonase YvrE	307
646479125	516	49.75	109	516	1	381	4.0e-128	451	COG2721	Altronate dehydratase	381
646479126	160	43.36	7	118	8	119	1.0e-33	135	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
646479127	224	35.23	16	208	1	182	2.0e-25	109	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646479131	270	39.75	33	270	2	237	2.0e-62	232	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
646479132	232	44.49	1	227	1	187	2.0e-60	225	COG0163	3-polyprenyl-4-hydroxybenzoate decarboxylase	191
646479133	385	23.95	1	233	1	230	2.0e-16	80.2	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646479134	180	40.83	11	178	10	175	2.0e-33	135	COG0461	Orotate phosphoribosyltransferase	201
646479136	239	36.46	37	217	2	178	3.0e-23	102	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646479139	402	29.74	4	402	14	408	8.0e-56	211	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646479140	1956	28.25	821	1303	11	442	5.0e-35	144	COG2319	WD40 repeat	466
646479147	452	32.76	163	452	1	287	1.0e-38	154	COG4976	Predicted methyltransferase, contains TPR repeat	287
646479155	685	39.53	1	542	8	542	0.0e+00	494	COG3501	Uncharacterized conserved protein, implicated in type VI secretion and phage assembly	550
646479157	353	29.75	11	318	2	319	5.0e-40	158	COG0515	Serine/threonine protein kinase	384
646479159	364	43.9	10	348	5	336	1.0e-97	350	COG1902	2,4-dienoyl-CoA reductase or related NADH-dependent reductase, Old Yellow Enzyme (OYE) family	363
646479162	297	29.64	39	281	3	250	6.0e-34	138	COG1801	Uncharacterized conserved protein YecE, DUF72 family	263
646479164	529	34.19	25	471	3	459	2.0e-86	313	COG3119	Arylsulfatase A or related enzyme	475
646479165	804	28.73	84	623	1	475	1.0e-79	291	COG3119	Arylsulfatase A or related enzyme	475
646479166	424	15.79	12	407	11	440	2.0e-06	47.3	COG2067	Long-chain fatty acid transport protein	440
646479170	490	26.21	1	449	2	428	6.0e-43	168	COG3522	Predicted component of the type VI protein secretion system	446
646479174	364	29.53	5	353	2	344	9.0e-24	104	COG3515	Predicted component of the type VI protein secretion system	346
646479175	170	59.52	4	170	2	169	2.0e-57	215	COG3516	Predicted component of the type VI protein secretion system	169
646479176	499	63.86	1	498	1	495	0.0e+00	786	COG3517	Predicted component of the type VI protein secretion system	495
646479177	166	27.81	1	163	4	162	2.0e-15	75.3	COG3157	Type VI protein secretion system component Hcp (secreted cytotoxin)	162
646479178	309	36.26	1	272	6	263	2.0e-63	236	COG4455	Protein of avirulence locus involved in temperature-dependent protein secretion	273
646479179	167	41.67	4	158	1	149	3.0e-23	101	COG3518	Predicted component of the type VI protein secretion system	157
646479180	625	45.99	1	622	1	618	0.0e+00	661	COG3519	Type VI protein secretion system component VasA	621
646479181	345	40.88	1	338	1	333	9.0e-79	287	COG3520	Predicted component of the type VI protein secretion system	335
646479182	915	35.87	12	914	1	783	0.0e+00	696	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
646479193	195	23.75	14	166	30	186	2.0e-09	55.6	COG0740	ATP-dependent protease ClpP, protease subunit	200
646479196	396	28.64	7	391	31	409	1.0e-34	141	COG5379	S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase	414
646479197	1016	26.41	280	558	2	272	3.0e-19	91.5	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646479199	446	55.58	10	443	6	443	0.0e+00	550	COG0160	4-aminobutyrate aminotransferase or related aminotransferase	447
646479200	516	36.83	39	503	11	470	4.0e-102	365	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646479201	686	51.4	43	682	13	650	0.0e+00	788	COG1166	Arginine decarboxylase (spermidine biosynthesis)	652
646479202	293	53.79	5	293	2	282	2.0e-100	358	COG0190	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase	283
646479204	509	29.82	71	336	1	281	3.0e-32	133	COG0515	Serine/threonine protein kinase	384
646479211	297	47.06	12	264	4	257	6.0e-75	274	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	260
646479223	373	62.33	8	153	2	146	3.0e-54	205	COG0117	Pyrimidine deaminase domain of riboflavin biosynthesis protein RibD	146
646479227	380	37.56	158	377	1	211	1.0e-39	157	COG0352	Thiamine monophosphate synthase	211
646479229	852	53.62	4	817	1	774	0.0e+00	919	COG0542	ATP-dependent Clp protease ATP-binding subunit ClpA	786
646479232	337	28.57	19	293	23	302	2.0e-42	166	COG3781	Predicted membrane chloride channel, bestrophin family	306
646479234	156	22.9	1	124	4	133	1.0e-06	46.1	COG3631	Ketosteroid isomerase-related protein	133
646479237	754	42.72	347	644	1	302	6.0e-76	279	COG1250	3-hydroxyacyl-CoA dehydrogenase	307
646479238	386	40.75	5	385	4	392	1.0e-75	277	COG0183	Acetyl-CoA acetyltransferase	392
646479239	385	30.93	15	378	6	368	3.0e-40	159	COG3616	D-serine deaminase, pyridoxal phosphate-dependent	368
646479241	194	32.02	9	186	5	177	3.0e-16	78.6	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646479243	82	64.71	1	82	1	85	2.0e-23	100	COG0211	Ribosomal protein L27	87
646479244	399	51.53	1	354	2	357	5.0e-128	451	COG0536	GTPase involved in cell partioning and DNA repair	369
646479245	260	29.17	1	255	1	248	3.0e-31	128	COG1521	Pantothenate kinase type III	251
646479246	484	26.79	64	484	13	395	2.0e-37	150	COG0126	3-phosphoglycerate kinase	395
646479247	109	32.32	1	98	5	103	3.0e-08	50.1	COG2198	HPt (histidine-containing phosphotransfer) domain	122
646479250	476	33.64	15	447	5	442	8.0e-70	257	COG3182	Uncharacterized iron-regulated membrane protein	442
646479257	431	33.43	66	421	3	311	4.0e-68	252	COG2355	Zn-dependent dipeptidase, microsomal dipeptidase homolog	313
646479260	410	30.18	26	402	10	392	7.0e-69	254	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
646479262	696	50.43	1	690	5	694	0.0e+00	780	COG0480	Translation elongation factor EF-G, a GTPase	697
646479265	358	25.34	1	355	1	348	3.0e-26	112	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
646479266	131	34.21	10	123	5	118	3.0e-19	87.6	COG3682	Predicted transcriptional regulator	123
646479267	607	22.99	142	398	66	321	7.0e-15	76.2	COG4219	Signal transducer regulating beta-lactamase production, contains  metallopeptidase domain	337
646479271	610	21.88	132	609	53	458	4.0e-26	113	COG0471	Di- and tricarboxylate transporter	461
646479272	436	23.4	48	394	6	328	8.0e-29	121	COG0673	Predicted dehydrogenase	342
646479273	522	27.62	2	521	6	570	5.0e-57	215	COG3653	N-acyl-D-aspartate/D-glutamate deacylase	579
646479274	980	22.89	169	542	33	398	9.0e-14	73.1	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646479275	1087	40.86	39	1083	10	1130	0.0e+00	1018	COG1197	Transcription-repair coupling factor (superfamily II helicase)	1139
646479276	490	15.42	233	458	67	291	1.0e-06	48.2	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
646479277	426	49.49	28	423	4	385	0.0e+00	463	COG0372	Citrate synthase	390
646479282	367	37.25	23	367	7	361	3.0e-70	259	COG0687	Spermidine/putrescine-binding periplasmic protein	363
646479283	270	41.02	10	264	7	262	2.0e-47	182	COG1177	ABC-type spermidine/putrescine transport system, permease component II	267
646479284	289	37.09	12	265	9	283	9.0e-41	160	COG1176	ABC-type spermidine/putrescine transport system, permease component I	287
646479285	358	41.08	5	351	1	351	1.0e-93	336	COG3842	ABC-type Fe3+/spermidine/putrescine transport systems, ATPase components	352
646479292	178	42	1	150	1	145	5.0e-22	97.6	COG3238	Uncharacterized membrane protein YdcZ, DUF606 family	150
646479293	1462	21.36	832	1123	26	332	4.0e-10	61.5	COG1413	HEAT repeat	335
646479295	190	42.11	1	188	3	189	9.0e-51	193	COG0424	Predicted house-cleaning NTP pyrophosphatase, Maf/HAM1 superfamily	193
646479296	310	43.13	1	310	4	312	2.0e-74	272	COG0123	Acetoin utilization deacetylase AcuC or a related deacetylase	340
646479297	1341	36.91	17	733	1	706	0.0e+00	522	COG1643	HrpA-like RNA helicase	845
646479298	346	26.06	10	290	1	266	1.0e-33	137	COG1091	dTDP-4-dehydrorhamnose reductase	281
646479299	948	21.42	17	628	2	564	3.0e-40	160	COG0443	Molecular chaperone DnaK (HSP70)	579
646479302	1742	34.39	262	412	9	157	2.0e-21	99.2	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
646479304	327	26.33	10	327	4	290	8.0e-33	134	COG0354	Folate-binding Fe-S cluster repair protein YgfZ, possible role in tRNA modification	305
646479312	187	24.07	39	145	1	106	2.0e-10	58.9	COG2165	Type II secretory pathway, pseudopilin PulG	149
646479313	224	42.03	15	221	5	211	7.0e-56	210	COG2344	NADH/NAD ratio-sensing transcriptional regulator Rex	211
646479314	248	30.86	73	245	4	178	9.0e-20	90.9	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646479318	873	20.41	12	392	29	398	3.0e-16	81.2	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646479319	238	53.47	35	236	7	204	3.0e-57	214	COG0545	FKBP-type peptidyl-prolyl cis-trans isomerase	205
646479320	292	45.77	98	285	1	200	1.0e-39	157	COG1573	Uracil-DNA glycosylase	202
646479321	486	44.32	1	439	1	440	3.0e-123	435	COG1160	Predicted GTPases	444
646479322	365	59.78	1	363	1	363	0.0e+00	478	COG0686	Alanine dehydrogenase	371
646479323	357	54.18	5	350	3	344	3.0e-122	431	COG0182	Methylthioribose-1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit	346
646479330	143	23.36	1	135	1	129	2.0e-08	52.1	COG0848	Biopolymer transport protein ExbD	137
646479331	139	25.35	1	139	1	137	3.0e-11	61.4	COG0848	Biopolymer transport protein ExbD	137
646479337	278	26.13	62	260	4	197	6.0e-21	94.7	COG0811	Biopolymer transport protein ExbB/TolQ	216
646479342	1145	21.3	1	394	8	399	1.0e-13	72.7	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646479344	246	34.96	4	240	2	244	4.0e-40	158	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
646479345	223	28.25	32	201	15	186	2.0e-22	99.7	COG4430	Uncharacterized conserved protein YdeI, YjbR/CyaY-like superfamily, DUF1801 family	200
646479346	294	29.37	1	284	11	292	2.0e-07	50.2	COG0697	Permease of the drug/metabolite transporter (DMT) superfamily	292
646479349	335	36.43	63	319	4	240	2.0e-30	126	COG1475	Chromosome segregation protein Spo0J, contains ParB-like nuclease domain	240
646479350	248	39.53	1	247	1	253	5.0e-55	207	COG1192	Cellulose biosynthesis protein BcsQ	259
646479351	449	23.28	4	448	3	404	2.0e-34	140	COG4198	Uncharacterized conserved protein, DUF1015 family	405
646479353	441	61.12	8	433	2	420	0.0e+00	648	COG0499	S-adenosylhomocysteine hydrolase	420
646479354	238	42.08	13	233	4	208	4.0e-50	191	COG0135	Phosphoribosylanthranilate isomerase	208
646479356	524	27.1	1	262	9	269	3.0e-21	97.3	COG3267	Type II secretory pathway, component ExeA (predicted ATPase)	269
646479358	310	40.45	5	309	4	310	1.0e-57	216	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646479359	461	20.99	88	407	43	359	2.0e-10	61	COG2814	Predicted arabinose efflux permease, MFS family	394
646479360	261	23.11	29	258	7	238	3.0e-12	65.9	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646479361	335	25.98	1	204	1	195	1.0e-12	67.2	COG0310	ABC-type Co2+ transport system, permease component	204
646479362	184	46.47	3	171	1	169	4.0e-43	167	COG0221	Inorganic pyrophosphatase	171
646479363	444	47.66	8	430	1	424	0.0e+00	490	COG0677	UDP-N-acetyl-D-mannosaminuronate dehydrogenase	436
646479367	156	31.08	9	156	1	129	1.0e-13	69.2	COG0251	Enamine deaminase RidA, house cleaning of reactive enamine intermediates, YjgF/YER057c/UK114 family	130
646479368	310	58.76	177	272	14	110	7.0e-40	157	COG0139	Phosphoribosyl-AMP cyclohydrolase	111
646479370	237	26.09	9	237	4	223	1.0e-17	83.3	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646479371	292	40.89	9	271	5	263	5.0e-59	221	COG0388	Predicted amidohydrolase	274
646479372	269	46.5	5	161	4	158	3.0e-40	159	COG0801	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	160
646479373	305	49.47	6	282	2	282	7.0e-95	340	COG0414	Panthothenate synthetase	285
646479375	285	28.01	4	281	9	284	5.0e-45	174	COG0788	Formyltetrahydrofolate hydrolase	287
646479376	454	37.08	7	182	2	179	2.0e-31	130	COG2059	Chromate transport protein ChrA	195
646479377	265	35.29	3	253	1	251	1.0e-41	163	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646479378	644	62.15	19	446	1	428	0.0e+00	647	COG2895	Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family	431
646479379	303	36.07	7	303	17	261	2.0e-56	212	COG0175	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase or related enzyme	261
646479380	156	25	18	141	1	122	3.0e-08	51.8	COG3011	Predicted thiol-disulfide oxidoreductase YuxK, DCC family	137
646479385	266	34.46	5	259	6	266	5.0e-41	161	COG1968	Undecaprenyl pyrophosphate phosphatase UppP	270
646479386	296	24.25	18	280	19	274	6.0e-13	68.3	COG1082	Sugar phosphate isomerase/epimerase	274
646479387	318	25	27	302	54	405	2.0e-31	129	COG1236	RNA processing exonuclease, beta-lactamase fold, Cft2 family	427
646479390	1305	18.7	722	1299	35	556	4.0e-23	104	COG1450	Type II secretory pathway component GspD/PulD (secretin)	587
646479391	161	46.56	4	134	2	122	6.0e-22	96.8	COG2363	Uncharacterized membrane protein YgdD, TMEM256/DUF423 family	124
646479392	178	37.18	23	172	1	155	2.0e-29	121	COG1225	Peroxiredoxin	157
646479393	676	50.37	5	669	4	666	0.0e+00	802	COG0272	NAD-dependent DNA ligase	667
646479396	966	45.75	19	949	6	933	0.0e+00	1056	COG0178	Excinuclease UvrABC ATPase subunit	935
646479398	345	50.2	1	252	3	254	1.0e-62	233	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
646479399	682	30.35	99	682	26	608	2.0e-74	274	COG4206	Outer membrane cobalamin receptor protein	608
646479406	109	32.73	1	109	1	110	9.0e-20	88.4	COG0607	Rhodanese-related sulfurtransferase	110
646479407	419	35.17	3	410	1	401	2.0e-61	229	COG0617	tRNA nucleotidyltransferase/poly(A) polymerase	412
646479418	162	33.56	1	146	3	148	1.0e-24	106	COG0835	Chemotaxis signal transduction protein	165
646479425	372	28.22	1	226	1	239	7.0e-20	92	COG3745	Flp pilus assembly protein CpaB	276
646479426	585	30.94	27	465	1	444	1.0e-61	231	COG4964	Flp pilus assembly protein, secretin CpaC	455
646479427	411	29.93	93	376	79	343	3.0e-34	139	COG4963	Flp pilus assembly protein, ATPase CpaE	366
646479429	208	47.4	8	199	4	191	1.0e-51	196	COG0127	Inosine/xanthosine triphosphate pyrophosphatase, all-alpha NTP-PPase family	194
646479430	125	67.23	1	119	6	124	5.0e-44	169	COG3651	Uncharacterized conserved protein, DUF2237 family	125
646479432	571	36.1	3	569	2	573	8.0e-106	378	COG0443	Molecular chaperone DnaK (HSP70)	579
646479445	149	45.26	9	144	3	137	3.0e-42	164	COG0432	Thiamin phosphate synthase YjbQ, UPF0047 family	137
646479447	207	43.35	1	200	4	205	4.0e-48	184	COG0125	Thymidylate kinase	208
646479448	332	27.9	9	326	6	310	2.0e-31	130	COG2378	Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains	311
646479458	380	35.6	3	380	1	357	2.0e-79	289	COG0821	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE	361
646479460	403	49.75	3	204	1	203	1.0e-67	250	COG0108	3,4-dihydroxy-2-butanone 4-phosphate synthase	203
646479465	428	23.11	17	425	5	391	3.0e-38	153	COG0644	Dehydrogenase (flavoprotein)	396
646479466	440	28.89	9	411	7	383	6.0e-32	132	COG0475	Kef-type K+ transport system, membrane component KefB	397
646479470	352	24.11	127	348	4	219	9.0e-19	87.9	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646479477	426	48.11	1	423	2	399	7.0e-125	440	COG0162	Tyrosyl-tRNA synthetase	401
646479480	343	40.12	10	329	7	326	6.0e-66	244	COG0714	MoxR-like ATPase	329
646479483	270	23.88	6	206	1	186	2.0e-18	86.7	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
646479485	396	25.25	1	298	1	288	3.0e-22	99.8	COG1463	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, periplasmic component MlaD	359
646479486	279	46.83	12	263	7	250	2.0e-81	295	COG1127	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, ATPase component MlaF	263
646479487	289	39.46	17	277	5	265	8.0e-57	214	COG0767	ABC-type transporter Mla maintaining outer membrane lipid asymmetry, permease component MlaE	267
646479488	380	38.73	27	370	127	499	6.0e-81	294	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646479489	355	23.62	12	341	58	388	3.0e-16	79.9	COG1459	Type II secretory pathway, component PulF	397
646479490	348	19.19	41	334	97	385	9.0e-11	61.4	COG1459	Type II secretory pathway, component PulF	397
646479491	419	22.88	92	403	67	381	5.0e-13	69.1	COG1459	Type II secretory pathway, component PulF	397
646479495	268	30.21	8	99	1	96	1.0e-10	60.5	COG3293	Transposase	124
646479497	419	37.07	8	378	1	323	5.0e-80	291	COG0523	GTPase, G3E family	323
646479499	278	20.54	1	242	2	256	4.0e-14	72.1	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646479501	1287	46.82	771	1284	1	522	0.0e+00	554	COG0146	N-methylhydantoinase B/oxoprolinase/acetone carboxylase, alpha subunit	563
646479502	539	29.87	268	488	17	243	4.0e-29	123	COG4242	Cyanophycinase and related exopeptidases	293
646479505	545	52.5	252	529	64	342	2.0e-79	290	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
646479507	590	41.03	52	555	12	491	8.0e-96	344	COG0608	Single-stranded DNA-specific exonuclease, DHH superfamily, may be involved in archaeal DNA replication intiation	491
646479509	535	37.18	7	513	1	465	1.0e-103	370	COG0034	Glutamine phosphoribosylpyrophosphate amidotransferase	470
646479510	846	18	92	297	68	305	1.0e-09	58.9	COG3386	Sugar lactone lactonase YvrE	307
646479511	353	49.29	1	351	1	340	2.0e-112	399	COG0150	Phosphoribosylaminoimidazole (AIR) synthetase	345
646479513	412	44.44	99	405	38	342	9.0e-60	224	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646479514	148	33.63	3	115	2	113	8.0e-16	76.6	COG1734	RNA polymerase-binding transcription factor DksA	120
646479518	248	32.39	1	245	1	236	2.0e-39	156	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	238
646479519	565	33.94	25	564	6	553	1.0e-121	430	COG3961	TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase	557
646479523	257	24.05	21	254	5	261	3.0e-26	112	COG0561	Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases	264
646479524	448	27.5	27	423	12	381	8.0e-40	158	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646479525	230	35.77	16	138	1	122	6.0e-15	74.6	COG1846	DNA-binding transcriptional regulator, MarR family	126
646479527	442	37.27	1	437	1	429	1.0e-111	396	COG0124	Histidyl-tRNA synthetase	429
646479530	699	45.27	3	698	5	697	0.0e+00	695	COG1523	Pullulanase/glycogen debranching enzyme	697
646479531	279	44.96	6	258	10	266	7.0e-70	257	COG0647	Ribonucleotide monophosphatase NagD, HAD superfamily	269
646479543	389	22.98	15	386	18	404	9.0e-44	171	COG0520	Selenocysteine lyase/Cysteine desulfurase	405
646479545	127	54.03	3	126	5	116	1.0e-33	135	COG3169	Uncharacterized conserved protein, DUF486 family	116
646479552	264	39.74	38	264	4	237	6.0e-35	141	COG2186	DNA-binding transcriptional regulator, FadR family	241
646479553	546	47.27	23	529	9	508	0.0e+00	551	COG0029	Aspartate oxidase	518
646479555	170	28.57	15	160	20	159	2.0e-10	58.8	COG1267	Phosphatidylglycerophosphatase A	160
646479560	1150	21.45	4	387	2	399	6.0e-16	80.8	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646479561	342	23.26	3	333	54	393	9.0e-31	128	COG1459	Type II secretory pathway, component PulF	397
646479564	308	29.75	1	305	1	314	2.0e-34	139	COG1397	ADP-ribosylglycohydrolase	314
646479565	332	23.91	56	321	1	274	4.0e-21	95.7	COG1082	Sugar phosphate isomerase/epimerase	274
646479566	143	55.37	1	120	1	121	4.0e-34	137	COG4401	Chorismate mutase	125
646479572	204	31.63	2	190	1	193	1.0e-32	133	COG2039	Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)	207
646479573	215	26.51	37	189	4	154	5.0e-07	48.3	COG1225	Peroxiredoxin	157
646479574	270	43.8	1	270	12	283	4.0e-66	244	COG0169	Shikimate 5-dehydrogenase	283
646479575	236	57.38	4	236	3	239	1.0e-79	289	COG0854	Pyridoxine 5'-phosphate synthase PdxJ	243
646479578	683	34.03	23	678	15	649	0.0e+00	472	COG2766	Predicted Ser/Thr protein kinase	649
646479579	369	29.21	8	367	18	417	8.0e-61	227	COG2718	Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family	423
646479580	505	33.93	14	497	15	489	2.0e-106	379	COG2719	Stage V sporulation protein SpoVR/YcgB, involved in spore cortex formation (function unknown)	495
646479582	196	26.01	9	175	7	178	2.0e-20	92.8	COG5018	Inhibitor of the KinA pathway to sporulation, predicted exonuclease	210
646479585	396	29.49	32	307	23	293	7.0e-32	131	COG1262	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain	314
646479586	329	26	208	307	36	135	2.0e-11	63.5	COG1886	Flagellar motor switch/type III secretory pathway protein FliN	136
646479587	321	38.98	14	306	3	266	2.0e-72	265	COG0648	Endonuclease IV	280
646479593	228	27.01	8	218	3	204	6.0e-16	77.9	COG1961	Site-specific DNA recombinase related to the DNA invertase Pin	222
646479602	295	40.96	22	207	19	205	4.0e-39	155	COG2930	Lipid-binding SYLF domain	227
646479606	146	34.62	29	142	1	130	2.0e-20	91.5	COG2764	Uncharacterized conserved protein PhnB, glyoxalase superfamily	136
646479607	908	61.82	8	907	1	861	0.0e+00	1177	COG1048	Aconitase A	861
646479608	491	50.33	1	449	1	449	0.0e+00	500	COG0541	Signal recognition particle GTPase	451
646479609	132	53.09	2	82	1	80	1.0e-22	98.8	COG0228	Ribosomal protein S16	87
646479610	273	51.28	1	234	1	231	5.0e-90	324	COG0336	tRNA G37 N-methylase TrmD	240
646479611	116	56.52	1	115	1	115	2.0e-35	140	COG0335	Ribosomal protein L19	115
646479612	150	44.07	26	142	2	114	6.0e-23	99	COG0792	Predicted endonuclease distantly related to archaeal Holliday junction resolvase	114
646479613	342	21.32	7	336	7	309	4.0e-17	82.7	COG2378	Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains	311
646479614	138	36.7	6	112	3	101	5.0e-13	66.8	COG2105	Uncharacterized conserved protein YtfP, gamma-glutamylcyclotransferase (GGCT)/AIG2-like family	120
646479615	909	19.08	1	887	1	887	3.0e-20	94.7	COG0419	DNA repair exonuclease SbcCD ATPase subunit	908
646479616	372	22.39	1	369	1	389	2.0e-21	97.2	COG0420	DNA repair exonuclease SbcCD nuclease subunit	390
646479617	1049	21.76	8	1045	12	1135	2.0e-72	268	COG1074	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)	1139
646479619	724	21.37	169	410	64	320	4.0e-08	53.9	COG0760	Parvulin-like peptidyl-prolyl isomerase	320
646479623	608	27.61	133	604	14	499	6.0e-52	198	COG0168	Trk-type K+ transport system, membrane component	499
646479624	225	33.19	3	223	2	216	5.0e-32	131	COG0569	Trk K+ transport system, NAD-binding component	225
646479632	270	44.1	70	258	3	197	6.0e-45	174	COG1611	Predicted Rossmann fold nucleotide-binding protein	205
646479636	1098	44.28	1	1074	2	1009	0.0e+00	935	COG0841	Multidrug efflux pump subunit AcrB	1009
646479637	441	30.67	13	394	2	370	1.0e-29	124	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646479638	546	54.08	20	545	5	526	0.0e+00	680	COG1866	Phosphoenolpyruvate carboxykinase, ATP-dependent	529
646479642	676	22.92	156	663	40	547	5.0e-62	232	COG0747	ABC-type transport system, periplasmic component	556
646479643	331	38.79	1	330	1	315	8.0e-74	270	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646479644	362	43.48	132	359	60	288	4.0e-64	238	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646479645	624	49.17	1	602	1	538	0.0e+00	647	COG1123	ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain	539
646479647	160	25.88	1	158	2	161	3.0e-18	84.7	COG0622	Predicted phosphodiesterase	172
646479649	366	23.24	3	355	2	342	3.0e-32	132	COG0673	Predicted dehydrogenase	342
646479657	131	51.56	2	129	7	134	4.0e-42	163	COG1803	Methylglyoxal synthase	142
646479662	1192	43.55	4	1167	2	1139	0.0e+00	1138	COG0587	DNA polymerase III, alpha subunit	1139
646479666	249	38.98	1	245	1	251	2.0e-43	169	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646479669	342	45.06	21	335	16	329	3.0e-66	245	COG0714	MoxR-like ATPase	329
646479675	1581	16.9	1064	1332	68	333	1.0e-06	50.2	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646479676	248	32.4	72	247	4	182	5.0e-21	95.1	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646479677	293	42.57	59	260	2	200	9.0e-42	163	COG3342	Uncharacterized conserved protein, Ntn-hydrolase superfamily	265
646479679	214	35.03	33	209	12	178	2.0e-28	119	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646479681	225	22.49	9	200	14	217	4.0e-20	91.9	COG2226	Ubiquinone/menaquinone biosynthesis C-methylase UbiE	238
646479683	356	44.35	6	356	5	345	2.0e-108	385	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
646479684	257	40.16	7	253	1	251	9.0e-49	186	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646479685	448	23.73	50	419	3	338	6.0e-33	135	COG0673	Predicted dehydrogenase	342
646479686	339	22.57	24	339	1	335	6.0e-16	78.7	COG0673	Predicted dehydrogenase	342
646479688	191	63.64	1	186	6	192	4.0e-76	277	COG0302	GTP cyclohydrolase I	195
646479691	999	30.12	17	512	8	457	8.0e-66	245	COG0277	FAD/FMN-containing dehydrogenase	459
646479692	86	30.49	9	86	3	84	3.0e-06	43.8	COG1977	Molybdopterin converting factor, small subunit	84
646479693	143	41.67	1	143	5	147	2.0e-35	141	COG0314	Molybdopterin synthase catalytic subunit	149
646479694	333	48.78	6	333	1	322	3.0e-98	352	COG2896	Molybdenum cofactor biosynthesis enzyme MoaA	322
646479696	389	43.67	8	386	24	405	1.0e-91	329	COG0520	Selenocysteine lyase/Cysteine desulfurase	405
646479700	286	34.33	4	134	2	117	6.0e-11	61.7	COG0517	CBS domain	117
646479701	173	28.08	7	146	4	146	5.0e-17	80.9	COG4276	Ligand-binding SRPBCC domain	153
646479702	304	45.9	4	303	2	297	6.0e-91	327	COG1090	NAD dependent epimerase/dehydratase family enzyme	297
646479704	362	20	21	274	26	240	3.0e-16	79.6	COG2333	Metal-dependent hydrolase, beta-lactamase superfamily II	293
646479706	576	36.96	28	573	12	534	5.0e-125	441	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646479707	386	20.47	1	378	1	355	1.0e-17	84.6	COG0795	Lipopolysaccharide export LptBFGC system, permease protein LptF	364
646479708	254	29.96	13	249	5	223	4.0e-21	95.5	COG1040	Predicted amidophosphoribosyltransferases	225
646479709	311	52.29	4	306	1	306	9.0e-95	340	COG0181	Porphobilinogen deaminase	307
646479710	250	34.72	1	247	1	264	3.0e-41	162	COG4786	Flagellar basal body rod protein FlgG	265
646479711	266	46.21	6	266	5	265	7.0e-68	250	COG4786	Flagellar basal body rod protein FlgG	265
646479713	242	22.18	3	239	1	230	5.0e-18	84.6	COG2063	Flagellar basal body L-ring protein FlgH	230
646479714	363	32.13	9	362	2	364	6.0e-39	155	COG1706	Flagellar basal body P-ring protein FlgI	365
646479717	565	28.8	1	565	1	550	1.0e-65	244	COG1256	Flagellar hook-associated protein FlgK	552
646479719	145	31.25	3	128	2	129	8.0e-19	86.5	COG1699	Flagellar assembly factor FliW	146
646479720	77	49.3	1	71	1	71	4.0e-17	79.6	COG1551	sRNA-binding carbon storage regulator CsrA	73
646479721	704	27.87	3	289	2	279	8.0e-22	99.4	COG1344	Flagellin and related hook-associated protein FlgL	360
646479722	1033	20.69	579	1019	17	475	7.0e-20	93.5	COG1345	Flagellar capping protein FliD	483
646479723	178	25.89	13	123	6	117	9.0e-10	56.8	COG1516	Flagellin-specific chaperone FliS	132
646479724	288	44.29	8	287	3	272	1.0e-78	286	COG2107	Predicted periplasmic solute-binding protein	272
646479727	379	36.96	12	379	11	323	3.0e-90	325	COG0379	Quinolinate synthase	324
646479735	314	24.5	1	297	51	318	1.0e-23	103	COG0614	ABC-type Fe3+-hydroxamate transport system, periplasmic component	319
646479738	308	35.71	20	294	4	292	3.0e-66	245	COG1131	ABC-type multidrug transport system, ATPase component	293
646479739	465	40.77	30	465	19	423	7.0e-105	374	COG0285	Folylpolyglutamate synthase/Dihydropteroate synthase	427
646479742	747	40.22	7	745	1	651	0.0e+00	582	COG0370	Fe2+ transport system protein B	653
646479743	79	45.95	6	79	1	74	2.0e-15	74.1	COG1918	Fe2+ transport system protein FeoA	75
646479745	546	28.4	6	517	3	465	2.0e-66	247	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
646479747	492	46.54	18	492	1	470	0.0e+00	530	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646479749	370	40.64	30	370	14	337	5.0e-96	344	COG1509	L-lysine 2,3-aminomutase (EF-P beta-lysylation pathway)	369
646479750	189	41.98	1	131	1	131	1.0e-34	139	COG0231	Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)	131
646479751	338	43.54	6	338	2	322	9.0e-82	297	COG2269	Elongation factor P--beta-lysine ligase (EF-P beta-lysylation pathway)	322
646479753	255	35.2	43	218	3	181	8.0e-32	130	COG0357	16S rRNA G527 N7-methylase RsmG (former glucose-inhibited division protein B)	215
646479754	323	25.55	66	321	14	272	5.0e-25	108	COG1082	Sugar phosphate isomerase/epimerase	274
646479755	427	42.69	1	419	1	420	4.0e-128	451	COG0172	Seryl-tRNA synthetase	429
646479756	456	27.39	1	456	1	409	3.0e-59	222	COG0624	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase or related deacylase	409
646479757	118	31.33	16	96	11	93	3.0e-10	57.3	COG2127	ATP-dependent Clp protease adapter protein ClpS	107
646479758	435	40.61	1	377	1	388	2.0e-108	386	COG0621	tRNA A37 methylthiotransferase MiaB	437
646479761	600	44.57	12	561	1	525	0.0e+00	471	COG0539	Ribosomal protein S1	541
646479762	320	43.82	35	298	61	327	9.0e-62	230	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
646479763	138	19.57	16	131	1	138	3.0e-07	47.9	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646479765	263	40.96	4	251	9	250	1.0e-58	219	COG1922	UDP-N-acetyl-D-mannosaminuronic acid transferase, WecB/TagA/CpsF family	253
646479769	440	21.33	43	394	3	321	8.0e-23	101	COG0673	Predicted dehydrogenase	342
646479770	558	47.06	5	540	1	530	0.0e+00	548	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646479771	431	43.42	1	427	1	425	2.0e-112	399	COG0128	5-enolpyruvylshikimate-3-phosphate synthase	428
646479772	409	16.84	53	407	1	362	1.0e-09	57.9	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646479775	313	34.88	20	298	14	288	4.0e-56	212	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646479776	240	24.39	60	240	11	214	8.0e-13	67.6	COG2755	Lysophospholipase L1 or related esterase	216
646479777	303	24.06	4	215	9	220	5.0e-25	108	COG1639	HD-like signal output (HDOD) domain, no enzymatic activity	289
646479782	158	38.71	2	154	1	152	3.0e-27	114	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
646479783	95	40.91	5	92	1	88	7.0e-19	85.6	COG1925	Phosphotransferase system, HPr and related phosphotransfer proteins	88
646479784	543	41.49	10	530	3	481	4.0e-114	405	COG1530	Ribonuclease G or E	487
646479785	104	57.28	1	103	1	102	1.0e-26	111	COG0261	Ribosomal protein L21	103
646479786	469	42.62	1	467	4	460	1.0e-125	443	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646479787	476	25.42	119	468	2	335	8.0e-27	115	COG0642	Signal transduction histidine kinase	336
646479788	401	46.47	16	401	11	398	2.0e-124	439	COG0649	NADH:ubiquinone oxidoreductase 49 kD subunit (chain D)	398
646479789	176	36.59	4	167	7	150	2.0e-28	118	COG0852	NADH:ubiquinone oxidoreductase 27 kD subunit (chain C)	176
646479790	225	41.76	1	91	1	87	4.0e-17	81.8	COG0838	NADH:ubiquinone oxidoreductase subunit 3 (chain A)	123
646479791	155	25	10	141	2	116	9.0e-15	73.1	COG4911	Uncharacterized protein	123
646479793	65	52.83	1	53	1	53	3.0e-13	66.9	COG1551	sRNA-binding carbon storage regulator CsrA	73
646479796	350	30.19	6	304	6	314	3.0e-60	225	COG0276	Protoheme ferro-lyase (ferrochelatase)	320
646479797	393	41.15	1	389	1	388	2.0e-73	269	COG0183	Acetyl-CoA acetyltransferase	392
646479798	328	40.51	8	318	1	310	5.0e-74	271	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646479801	771	30.71	523	757	20	254	4.0e-34	140	COG2912	Regulator of sirC expression, contains transglutaminase-like and TPR domains	269
646479803	130	33.33	1	117	4	125	1.0e-11	62.4	COG1051	ADP-ribose pyrophosphatase YjhB, NUDIX family	145
646479804	276	50.57	1	264	1	256	2.0e-83	302	COG0623	Enoyl-[acyl-carrier-protein] reductase (NADH)	259
646479808	266	30.63	1	264	2	282	3.0e-26	112	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646479814	274	23.92	46	254	4	210	8.0e-24	104	COG0811	Biopolymer transport protein ExbB/TolQ	216
646479815	139	31.25	7	133	10	133	2.0e-18	84.9	COG0848	Biopolymer transport protein ExbD	137
646479818	132	51.35	16	126	22	132	1.0e-34	138	COG0780	NADPH-dependent 7-cyano-7-deazaguanine reductase QueF, C-terminal domain, T-fold superfamily	149
646479819	391	44.19	2	388	1	382	7.0e-100	357	COG1641	Uncharacterized conserved protein, DUF111 family	387
646479820	369	22.76	5	356	14	367	2.0e-26	113	COG2232	Predicted ATP-dependent carboligase, ATP-grasp superfamily	389
646479821	276	26.98	3	248	1	248	5.0e-24	105	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
646479822	471	29.46	23	465	17	455	2.0e-51	197	COG0534	Na+-driven multidrug efflux pump	455
646479823	150	49.32	1	148	7	151	3.0e-42	164	COG2947	Predicted RNA-binding protein, contains PUA-like domain	156
646479826	352	44.71	8	344	10	344	8.0e-102	363	COG2957	Agmatine/peptidylarginine deiminase	346
646479827	297	36.71	9	291	1	273	7.0e-56	211	COG0388	Predicted amidohydrolase	274
646479828	388	43.86	7	343	1	337	7.0e-83	301	COG1600	Epoxyqueuosine reductase  QueG (queuosine biosynthesis)	337
646479829	280	23.13	3	270	2	269	3.0e-23	102	COG1082	Sugar phosphate isomerase/epimerase	274
646479832	429	23.35	5	393	3	343	1.0e-35	144	COG0205	6-phosphofructokinase	347
646479834	287	17.74	71	246	15	197	7.0e-08	51.7	COG0546	Phosphoglycolate phosphatase, HAD superfamily	220
646479835	483	60.62	1	480	1	473	0.0e+00	744	COG0362	6-phosphogluconate dehydrogenase	473
646479836	260	34.51	9	256	1	251	3.0e-40	158	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646479837	486	50.82	1	478	6	480	0.0e+00	604	COG0364	Glucose-6-phosphate 1-dehydrogenase	483
646479841	391	30.54	85	377	7	303	8.0e-38	151	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646479842	663	32.59	24	644	5	575	2.0e-123	436	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
646479843	218	27.33	36	193	20	191	1.0e-09	56.8	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
646479846	157	52.08	10	150	4	142	3.0e-40	157	COG0328	Ribonuclease HI	154
646479849	680	27.16	105	422	1	304	4.0e-32	133	COG0515	Serine/threonine protein kinase	384
646479850	214	27.27	15	212	1	176	1.0e-11	63.6	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646479858	252	36.71	14	247	6	238	2.0e-42	166	COG3541	Predicted nucleotidyltransferase	248
646479859	234	24.53	9	203	4	211	6.0e-17	81.1	COG3541	Predicted nucleotidyltransferase	248
646479861	547	18.14	327	545	11	213	1.0e-07	51.8	COG2755	Lysophospholipase L1 or related esterase	216
646479863	553	23.78	266	546	16	309	6.0e-22	99.6	COG0657	Acetyl esterase/lipase	312
646479864	245	18.48	52	237	9	216	5.0e-06	44.9	COG2755	Lysophospholipase L1 or related esterase	216
646479867	304	22.18	45	276	61	286	2.0e-09	56.9	COG0189	Glutathione synthase/RimK-type ligase, ATP-grasp superfamily	318
646479869	234	34.55	124	233	12	121	5.0e-19	88.4	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646479871	162	53.85	1	156	1	156	2.0e-50	191	COG1327	Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains	156
646479873	494	32.99	3	489	1	441	3.0e-88	319	COG1508	DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog	444
646479874	199	47.69	5	199	4	198	3.0e-65	241	COG0353	Recombinational DNA repair protein RecR	198
646479875	715	40.49	42	488	3	441	8.0e-117	414	COG2812	DNA polymerase III, gamma/tau subunits	515
646479877	200	38.32	24	190	3	162	1.0e-28	119	COG1795	Formaldehyde-activating enzyme nesessary for methanogenesis	170
646479878	220	29.82	1	215	11	218	6.0e-27	114	COG1418	HD superfamily phosphodieaserase, includes HD domain of RNase Y	222
646479879	774	21.63	4	465	2	401	4.0e-23	103	COG1668	ABC-type Na+ efflux pump, permease component	407
646479880	267	45.31	1	245	1	241	3.0e-68	252	COG4555	ABC-type Na+ transport system, ATPase component NatA	245
646479881	442	17.49	31	365	38	383	2.0e-08	53.7	COG0606	Predicted ATPase with chaperone activity	490
646479883	320	45.96	1	313	13	334	4.0e-85	308	COG1702	Phosphate starvation-inducible protein PhoH, predicted ATPase	348
646479884	783	27.9	20	779	2	694	2.0e-101	364	COG1480	Membrane-associated HD superfamily phosphohydrolase	700
646479885	143	30.61	1	142	2	148	4.0e-22	97.3	COG0319	ssRNA-specific RNase YbeY, 16S rRNA maturation enzyme	153
646479891	451	47.64	145	440	29	316	1.0e-64	240	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646479892	333	34.84	50	333	33	313	4.0e-44	171	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646479893	541	19.11	184	525	1	320	4.0e-09	56.8	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646479894	295	34.71	11	292	11	298	5.0e-48	184	COG2421	Acetamidase/formamidase	305
646479895	600	27.42	25	453	1	454	6.0e-55	209	COG3119	Arylsulfatase A or related enzyme	475
646479896	173	29.17	1	150	2	169	3.0e-14	72	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
646479898	696	45.65	1	694	1	687	0.0e+00	661	COG0480	Translation elongation factor EF-G, a GTPase	697
646479899	156	46.9	5	149	5	148	1.0e-43	169	COG0049	Ribosomal protein S7	148
646479900	122	71.9	1	121	7	127	1.0e-44	171	COG0048	Ribosomal protein S12	129
646479901	1447	45.34	16	844	6	808	0.0e+00	781	COG0086	DNA-directed RNA polymerase, beta' subunit/160 kD subunit	808
646479902	1240	44.54	12	873	10	808	0.0e+00	741	COG0085	DNA-directed RNA polymerase, beta subunit/140 kD subunit	1060
646479904	130	44.88	4	130	1	124	3.0e-19	87.6	COG0222	Ribosomal protein L7/L12	124
646479905	184	26.01	1	173	3	174	3.0e-18	84.9	COG0244	Ribosomal protein L10	175
646479906	228	55.02	1	228	1	228	8.0e-75	273	COG0081	Ribosomal protein L1	228
646479907	143	58.27	5	143	2	140	9.0e-44	169	COG0080	Ribosomal protein L11	141
646479908	267	37.02	88	267	1	177	8.0e-39	154	COG0250	Transcription antitermination factor NusG	178
646479909	146	33.33	87	140	20	73	8.0e-06	43.1	COG0690	Preprotein translocase subunit SecE	73
646479911	398	70.93	1	398	1	394	0.0e+00	612	COG0050	Translation elongation factor EF-Tu, a GTPase	394
646479922	144	43.06	1	143	1	137	2.0e-34	138	COG0432	Thiamin phosphate synthase YjbQ, UPF0047 family	137
646479924	300	21.2	30	277	4	218	2.0e-06	47	COG3828	Type 1 glutamine amidotransferase (GATase1)-like domain	239
646479925	257	26.21	5	205	9	195	2.0e-13	69.7	COG3361	Uncharacterized protein YqjF, DUF2071 family	240
646479926	275	30.08	32	273	5	256	8.0e-31	127	COG0584	Glycerophosphoryl diester phosphodiesterase	257
646479930	635	32.74	509	619	18	126	2.0e-08	54.9	COG0526	Thiol-disulfide isomerase or thioredoxin	127
646479939	564	32.21	7	551	16	610	1.0e-112	400	COG1022	Long-chain acyl-CoA synthetase (AMP-forming)	613
646479940	615	29.09	122	475	37	386	4.0e-38	153	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
646479941	247	42.61	1	228	2	229	2.0e-51	195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	230
646479943	389	29.63	4	218	2	207	3.0e-33	136	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
646479944	148	53.69	1	147	1	149	5.0e-41	159	COG0698	Ribose 5-phosphate isomerase RpiB	151
646479954	299	22.38	27	297	43	297	1.0e-18	87.7	COG2382	Enterochelin esterase or related enzyme	299
646479955	226	36.57	1	215	9	224	5.0e-35	140	COG0704	Phosphate uptake regulator	240
646479956	236	46.49	5	227	2	227	1.0e-52	199	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646479957	192	49.47	5	190	9	196	2.0e-57	215	COG0307	Riboflavin synthase alpha chain	204
646479958	308	37.5	19	298	1	258	3.0e-63	235	COG0030	16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity)	259
646479959	107	60.19	4	106	2	104	2.0e-30	124	COG0051	Ribosomal protein S10	104
646479960	232	41.28	2	232	1	213	2.0e-55	209	COG0087	Ribosomal protein L3	218
646479961	209	41.63	1	206	1	209	1.0e-44	173	COG0088	Ribosomal protein L4	214
646479962	104	50	16	104	2	91	1.0e-20	91.8	COG0089	Ribosomal protein L23	94
646479963	285	54.91	1	275	1	274	6.0e-99	354	COG0090	Ribosomal protein L2	275
646479964	89	64.04	1	89	1	89	2.0e-31	126	COG0185	Ribosomal protein S19	93
646479965	118	45.3	1	117	9	120	6.0e-23	99.5	COG0091	Ribosomal protein L22	120
646479966	237	51.1	12	237	1	222	2.0e-60	225	COG0092	Ribosomal protein S3	233
646479967	138	49.64	1	135	1	137	1.0e-35	141	COG0197	Ribosomal protein L16/L10AE	146
646479968	69	41.18	1	68	1	68	4.0e-06	42.9	COG0255	Ribosomal protein L29	69
646479969	92	48.15	1	81	6	86	1.0e-16	77.9	COG0186	Ribosomal protein S17	87
646479970	122	65.57	1	122	1	122	7.0e-44	169	COG0093	Ribosomal protein L14	122
646479971	111	48.51	1	100	3	101	5.0e-19	86.1	COG0198	Ribosomal protein L24	104
646479972	185	52.81	2	179	1	178	4.0e-60	224	COG0094	Ribosomal protein L5	180
646479973	61	57.38	1	61	1	61	5.0e-15	72.9	COG0199	Ribosomal protein S14	61
646479974	131	55.73	1	131	2	132	1.0e-42	165	COG0096	Ribosomal protein S8	132
646479975	181	50	1	179	1	177	1.0e-48	186	COG0097	Ribosomal protein L6P/L9E	178
646479976	122	59.13	10	122	11	125	2.0e-30	124	COG0256	Ribosomal protein L18	125
646479978	161	47.83	1	160	15	175	2.0e-43	168	COG0098	Ribosomal protein S5	181
646479979	169	44.37	1	147	1	151	1.0e-26	112	COG0200	Ribosomal protein L15	152
646479980	461	40.31	1	459	6	431	2.0e-100	359	COG0201	Preprotein translocase subunit SecY	436
646479981	196	46.45	1	183	1	175	1.0e-43	169	COG0563	Adenylate kinase or related kinase	178
646479983	127	61.98	1	121	1	121	2.0e-40	157	COG0099	Ribosomal protein S13	121
646479984	126	59.52	1	126	4	129	1.0e-41	161	COG0100	Ribosomal protein S11	129
646479985	330	43.89	8	326	1	311	7.0e-84	304	COG0202	DNA-directed RNA polymerase, alpha subunit/40 kD subunit	317
646479986	192	37.06	1	170	1	116	1.0e-24	106	COG0203	Ribosomal protein L17	116
646479989	490	22.07	114	470	87	427	2.0e-17	84.7	COG1653	ABC-type glycerol-3-phosphate transport system, periplasmic component	433
646479990	307	27.72	8	303	23	311	1.0e-34	140	COG1907	Predicted archaeal sugar kinase	312
646479991	209	23.68	12	192	14	196	9.0e-12	63.8	COG2457	Uncharacterized protein	199
646479992	221	57.89	1	189	3	191	4.0e-75	274	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
646479993	473	39.62	14	471	7	454	1.0e-112	400	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
646479994	487	24.89	239	449	70	274	1.0e-06	48.4	COG0294	Dihydropteroate synthase	274
646479995	266	38.82	14	260	3	251	4.0e-36	145	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646479996	566	17.49	209	542	35	341	1.0e-06	48.3	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646479997	1107	20.1	23	387	23	398	9.0e-14	73.1	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646480003	405	34.09	64	402	14	339	5.0e-54	205	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480004	507	52.07	1	505	2	500	0.0e+00	610	COG1129	ABC-type sugar transport system, ATPase component	500
646480005	401	33.23	11	344	7	316	2.0e-36	146	COG1172	Ribose/xylose/arabinose/galactoside ABC-type transport system, permease component	316
646480006	376	25.91	14	310	5	291	3.0e-26	112	COG1879	ABC-type sugar transport system, periplasmic component, contains N-terminal xre family HTH domain	322
646480007	289	24.23	34	289	2	284	1.0e-19	91	COG0515	Serine/threonine protein kinase	384
646480008	433	31.08	20	431	11	388	1.0e-71	263	COG0247	Fe-S oxidoreductase	388
646480009	419	27.66	14	414	35	456	8.0e-40	158	COG0277	FAD/FMN-containing dehydrogenase	459
646480010	479	38.96	12	463	1	459	2.0e-84	306	COG0277	FAD/FMN-containing dehydrogenase	459
646480011	411	35.84	18	409	5	403	4.0e-100	358	COG0579	L-2-hydroxyglutarate oxidase LhgO	429
646480014	356	49.41	20	353	4	332	2.0e-100	359	COG0533	tRNA A37 threonylcarbamoyltransferase TsaD	342
646480018	1215	48.66	294	1174	1	804	0.0e+00	885	COG4196	Uncharacterized conserved protein, DUF2126 family	808
646480019	165	64.24	1	165	1	165	1.0e-57	215	COG1795	Formaldehyde-activating enzyme nesessary for methanogenesis	170
646480022	338	38.19	2	191	58	252	4.0e-36	145	COG2041	Periplasmic DMSO/TMAO reductase YedYZ, molybdopterin-dependent catalytic subunit	271
646480026	247	34.21	24	245	17	243	4.0e-42	165	COG2935	Arginyl-tRNA--protein-N-Asp/Glu arginylyltransferase	253
646480027	485	42.47	25	461	1	432	1.0e-121	430	COG0305	Replicative DNA helicase	435
646480028	179	38.36	22	167	1	146	2.0e-30	125	COG0359	Ribosomal protein L9	148
646480029	159	41.82	4	159	3	167	3.0e-27	114	COG0629	Single-stranded DNA-binding protein	167
646480030	131	25.81	6	98	3	95	5.0e-16	76.8	COG0360	Ribosomal protein S6	112
646480031	189	48.15	1	188	2	190	3.0e-59	221	COG0193	Peptidyl-tRNA hydrolase	190
646480032	208	30.77	5	92	3	93	4.0e-14	71.4	COG1825	Ribosomal protein L25 (general stress protein Ctc)	93
646480034	111	28.26	12	99	3	93	9.0e-07	45.5	COG0234	Co-chaperonin GroES (HSP10)	96
646480036	318	56.69	1	314	2	314	4.0e-114	404	COG0462	Phosphoribosylpyrophosphate synthetase	314
646480038	294	49.26	22	291	1	264	3.0e-68	252	COG0548	Acetylglutamate kinase	265
646480039	406	47.24	13	406	5	402	0.0e+00	480	COG4992	Acetylornithine/succinyldiaminopimelate/putrescine aminotransferase	404
646480040	305	52.61	1	302	6	310	3.0e-104	371	COG0078	Ornithine carbamoyltransferase	310
646480041	247	53.36	2	238	12	230	2.0e-65	242	COG0689	Ribonuclease PH	230
646480043	483	26.67	28	439	1	448	5.0e-45	175	COG3119	Arylsulfatase A or related enzyme	475
646480044	75	40.62	1	64	1	64	2.0e-12	63.8	COG1551	sRNA-binding carbon storage regulator CsrA	73
646480045	293	22.64	32	278	13	257	2.0e-14	73.5	COG5285	Ectoine hydroxylase-related dioxygenase, phytanoyl-CoA dioxygenase (PhyH) family	299
646480046	300	23.74	17	285	26	300	2.0e-17	83	COG0657	Acetyl esterase/lipase	312
646480047	288	40.17	25	257	3	220	2.0e-50	192	COG2013	Uncharacterized conserved protein, AIM24 family	227
646480048	409	32.97	30	396	30	388	3.0e-66	245	COG0498	Threonine synthase	411
646480050	255	26.17	32	242	27	231	1.0e-21	96.9	COG1861	Spore coat polysaccharide biosynthesis protein SpsF, cytidylyltransferase family	241
646480051	234	22.55	1	234	2	236	1.0e-17	83.4	COG1579	Predicted  nucleic acid-binding protein, contains Zn-ribbon domain	239
646480052	544	45.59	220	539	14	341	1.0e-77	284	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
646480054	613	32.22	8	482	8	471	2.0e-79	290	COG0358	DNA primase (bacterial type)	568
646480061	354	43.94	17	337	8	327	1.0e-69	256	COG0714	MoxR-like ATPase	329
646480065	636	32.12	240	596	20	335	8.0e-48	185	COG0642	Signal transduction histidine kinase	336
646480066	411	38.83	1	410	6	403	3.0e-84	305	COG0303	Molybdopterin biosynthesis enzyme	404
646480067	193	56.99	1	193	3	190	2.0e-72	265	COG0512	Anthranilate/para-aminobenzoate synthase component II	191
646480068	247	29.06	33	234	14	214	4.0e-24	105	COG2802	Uncharacterized protein, similar to the N-terminal domain of Lon protease	221
646480069	191	46.52	6	190	3	186	5.0e-45	174	COG0424	Predicted house-cleaning NTP pyrophosphatase, Maf/HAM1 superfamily	193
646480070	230	36.04	2	218	73	288	3.0e-43	168	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646480071	478	26.35	75	406	2	351	3.0e-42	166	COG0515	Serine/threonine protein kinase	384
646480073	792	19.04	342	752	95	534	7.0e-17	83.1	COG0747	ABC-type transport system, periplasmic component	556
646480075	296	21.85	144	294	6	137	1.0e-09	57.1	COG0848	Biopolymer transport protein ExbD	137
646480076	158	23.49	11	158	5	136	4.0e-09	54.5	COG0848	Biopolymer transport protein ExbD	137
646480077	215	24.26	39	207	45	210	6.0e-16	77.7	COG0811	Biopolymer transport protein ExbB/TolQ	216
646480083	689	31.65	53	358	36	339	8.0e-41	162	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480084	345	27.17	1	340	2	337	2.0e-25	109	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480085	424	30.46	30	359	10	347	3.0e-36	146	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480086	1146	57.68	2	1146	5	1148	0.0e+00	1657	COG1038	Pyruvate carboxylase	1149
646480087	266	35.39	21	259	1	233	2.0e-39	156	COG0340	Biotin-(acetyl-CoA carboxylase) ligase	238
646480094	490	23.1	77	489	42	461	7.0e-27	115	COG0531	Amino acid transporter	466
646480095	429	21.2	140	429	16	319	1.0e-10	61.4	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646480099	364	27.19	20	131	9	122	1.0e-07	50.8	COG2165	Type II secretory pathway, pseudopilin PulG	149
646480101	814	74.66	74	806	12	729	0.0e+00	1199	COG0376	Catalase (peroxidase I)	730
646480102	288	34.47	1	288	1	289	4.0e-39	155	COG0583	DNA-binding transcriptional regulator, LysR family	297
646480103	128	35.34	1	116	1	116	2.0e-24	104	COG3795	Uncharacterized conserved protein	123
646480115	583	28.49	13	551	141	678	1.0e-69	258	COG2274	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	709
646480116	459	17.26	36	395	19	310	1.0e-06	48	COG1566	Multidrug resistance efflux pump	352
646480117	610	18.45	167	604	43	443	2.0e-20	94.4	COG1538	Outer membrane protein TolC	457
646480120	178	29.55	1	130	2	133	7.0e-24	103	COG1959	DNA-binding transcriptional regulator, IscR family	150
646480121	270	40.49	1	241	1	236	3.0e-56	212	COG0363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase	238
646480122	346	24.49	154	346	26	216	8.0e-17	81.7	COG0705	Membrane associated serine protease, rhomboid family	228
646480123	386	34.18	8	164	11	162	1.0e-24	107	COG1546	Nicotinamide mononucleotide (NMN) deamidase PncC	162
646480133	680	34.89	42	286	1	277	6.0e-37	149	COG0515	Serine/threonine protein kinase	384
646480135	222	22.4	8	199	2	177	3.0e-12	65.5	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646480137	72	39.29	21	72	8	63	9.0e-08	48.5	COG4256	Hemin uptake protein HemP	63
646480138	401	40.7	4	401	1	377	2.0e-96	346	COG1454	Alcohol dehydrogenase, class IV	377
646480142	514	51.81	14	510	1	489	0.0e+00	547	COG0606	Predicted ATPase with chaperone activity	490
646480144	557	28.81	22	487	1	441	1.0e-52	201	COG4145	Na+/panthothenate symporter	473
646480145	561	27.7	23	558	9	461	6.0e-46	179	COG0471	Di- and tricarboxylate transporter	461
646480149	133	22.48	5	133	9	135	1.0e-07	48.7	COG0848	Biopolymer transport protein ExbD	137
646480150	144	22.66	1	128	2	125	3.0e-06	44.4	COG0848	Biopolymer transport protein ExbD	137
646480151	327	28.91	91	300	11	209	2.0e-26	113	COG0811	Biopolymer transport protein ExbB/TolQ	216
646480152	2545	20.1	2351	2527	50	253	8.0e-08	54.9	COG4105	Outer membrane protein assembly factor BamD, BamD/ComL family	254
646480161	130	23.19	1	126	1	138	4.0e-07	47.1	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646480162	288	58.85	29	288	2	253	2.0e-114	405	COG1117	ABC-type phosphate transport system, ATPase component	253
646480163	318	36.21	19	315	4	291	5.0e-55	208	COG0581	ABC-type phosphate transport system, permease component	292
646480164	321	40.66	22	321	8	310	7.0e-61	227	COG0573	ABC-type phosphate transport system, permease component	310
646480165	352	32.29	9	317	13	318	2.0e-54	206	COG0226	ABC-type phosphate transport system, periplasmic component	318
646480166	137	36.22	1	126	2	128	7.0e-28	116	COG0824	Acyl-CoA thioesterase FadM	137
646480169	301	34.23	2	296	15	269	3.0e-53	202	COG0130	tRNA U55 pseudouridine synthase TruB, may also work on U342 of tmRNA	271
646480170	502	23.57	28	495	18	446	2.0e-43	170	COG2079	2-methylcitrate dehydratase PrpD	453
646480171	338	61.7	12	338	5	328	0.0e+00	495	COG0113	Delta-aminolevulinic acid dehydratase, porphobilinogen synthase	330
646480172	438	57.21	10	438	1	430	0.0e+00	589	COG0001	Glutamate-1-semialdehyde aminotransferase	432
646480174	522	64.58	204	522	1	315	0.0e+00	510	COG0519	GMP synthase, PP-ATPase domain/subunit	315
646480175	255	46.06	1	248	1	250	7.0e-71	260	COG0496	Broad specificity polyphosphatase and 5'/3'-nucleotidase SurE	252
646480181	245	38.74	4	222	76	288	1.0e-48	186	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646480182	422	22.97	42	392	7	339	2.0e-34	139	COG0673	Predicted dehydrogenase	342
646480184	306	26.54	7	303	2	309	7.0e-27	114	COG0524	Sugar or nucleoside kinase, ribokinase family	311
646480186	243	27.27	83	232	1	150	2.0e-17	82.7	COG1762	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)	152
646480188	266	36.3	1	262	1	259	3.0e-56	211	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
646480192	745	55.03	106	735	1	628	0.0e+00	776	COG0296	1,4-alpha-glucan branching enzyme	628
646480196	195	36.5	2	193	1	186	1.0e-27	116	COG0693	Putative intracellular protease/amidase	188
646480197	280	37.45	35	273	3	243	2.0e-48	185	COG2071	Gamma-glutamyl-gamma-aminobutyrate hydrolase PuuD (putrescine degradation), contains GATase1-like domain	243
646480201	433	35	1	430	1	409	4.0e-69	255	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646480203	355	48.04	37	340	2	288	4.0e-77	281	COG0564	Pseudouridylate synthase, 23S rRNA- or tRNA-specific	289
646480204	253	28.14	10	236	7	230	1.0e-27	117	COG2120	N-acetylglucosaminyl deacetylase, LmbE family	237
646480207	292	28.52	1	279	10	293	4.0e-39	155	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
646480208	863	44.7	22	500	7	487	0.0e+00	503	COG2308	Uncharacterized conserved protein, circularly permuted ATPgrasp superfamily	488
646480209	332	39.43	1	313	1	309	1.0e-76	280	COG2307	Uncharacterized conserved protein, Alpha-E superfamily	313
646480210	482	57.94	11	475	11	476	0.0e+00	628	COG2308	Uncharacterized conserved protein, circularly permuted ATPgrasp superfamily	488
646480215	1097	30.07	159	446	1	303	4.0e-39	157	COG0515	Serine/threonine protein kinase	384
646480216	536	31.44	1	533	4	553	7.0e-83	301	COG0747	ABC-type transport system, periplasmic component	556
646480217	334	41.72	1	334	1	316	3.0e-74	272	COG0601	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	317
646480218	253	50.2	1	252	33	287	5.0e-62	231	COG1173	ABC-type dipeptide/oligopeptide/nickel transport system, permease component	289
646480219	221	26.09	14	151	9	142	8.0e-18	84.2	COG1853	NADH-FMN oxidoreductase RutF, flavin reductase (DIM6/NTAB) family	176
646480221	775	21.8	48	168	5	134	8.0e-08	52.9	COG1225	Peroxiredoxin	157
646480223	432	63.62	1	426	1	423	0.0e+00	622	COG0148	Enolase	423
646480228	333	30.42	2	301	1	271	3.0e-33	136	COG0388	Predicted amidohydrolase	274
646480229	395	25.13	3	391	13	384	3.0e-34	139	COG0006	Xaa-Pro aminopeptidase	384
646480230	389	35.09	11	384	13	379	8.0e-67	247	COG1820	N-acetylglucosamine-6-phosphate deacetylase	380
646480232	606	33.33	1	585	1	561	6.0e-86	312	COG1966	Carbon starvation protein CstA	575
646480238	152	36.17	55	148	3	96	2.0e-17	81.6	COG1359	Quinol monooxygenase YgiN	100
646480239	327	30.4	5	327	3	311	2.0e-40	159	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646480241	313	26.83	71	274	11	211	9.0e-20	91.2	COG0811	Biopolymer transport protein ExbB/TolQ	216
646480242	138	35.66	6	134	8	132	7.0e-17	79.9	COG0848	Biopolymer transport protein ExbD	137
646480244	443	31.39	20	415	6	400	2.0e-52	200	COG1078	HD superfamily phosphohydrolase	421
646480247	153	28.26	9	146	3	139	2.0e-17	81.5	COG4747	Uncharacterized conserved protein, contains tandem ACT domains	142
646480255	406	46.08	20	222	1	204	6.0e-61	228	COG2518	Protein-L-isoaspartate O-methyltransferase	209
646480257	265	39.6	1	250	3	250	4.0e-51	194	COG3836	2-keto-3-deoxy-L-rhamnonate aldolase RhmA	255
646480258	413	45.89	3	400	5	399	3.0e-99	355	COG5441	Uncharacterized protein, UPF0261 family	401
646480259	279	61.09	1	275	1	275	2.0e-95	341	COG5564	Predicted TIM-barrel enzyme	276
646480260	566	24.16	27	411	1	465	3.0e-40	160	COG3119	Arylsulfatase A or related enzyme	475
646480261	310	36.48	1	305	4	293	2.0e-66	246	COG1131	ABC-type multidrug transport system, ATPase component	293
646480263	114	27.03	22	94	12	85	4.0e-09	53.4	COG1694	NTP pyrophosphatase, house-cleaning of non-canonical NTPs	102
646480264	107	32.35	1	99	2	103	3.0e-17	80.4	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	106
646480266	226	32.79	1	226	7	250	3.0e-35	141	COG2220	L-ascorbate metabolism protein UlaG, beta-lactamase superfamily	258
646480267	471	31.73	82	468	58	429	3.0e-55	209	COG0166	Glucose-6-phosphate isomerase	446
646480268	401	43.28	13	395	1	408	2.0e-105	376	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archeal type	408
646480273	801	23.56	418	615	56	252	2.0e-08	55.4	COG5426	Uncharacterized membrane protein	254
646480276	351	46.44	18	331	16	328	5.0e-67	248	COG0714	MoxR-like ATPase	329
646480281	150	40.71	7	146	42	177	3.0e-22	98	COG2322	Uncharacterized membrane protein YozB, DUF420 family	177
646480282	265	21.83	2	186	1	187	3.0e-19	89.3	COG1999	Cytochrome oxidase Cu insertion factor, SCO1/SenC/PrrC family	207
646480283	288	29.69	29	282	38	286	2.0e-08	53.4	COG0842	ABC-type multidrug transport system, permease component	286
646480284	323	38.87	13	311	3	292	9.0e-69	253	COG1131	ABC-type multidrug transport system, ATPase component	293
646480287	301	36.09	1	301	1	299	2.0e-49	189	COG0109	Polyprenyltransferase (heme O synthase)	304
646480288	382	22.26	30	294	35	284	4.0e-10	59.6	COG1612	Heme A synthase	323
646480289	601	45.42	24	568	7	520	1.0e-130	460	COG0843	Heme/copper-type cytochrome/quinol oxidase, subunit 1	566
646480290	269	29.71	14	252	4	223	3.0e-41	162	COG1622	Heme/copper-type cytochrome/quinol oxidase, subunit 2	247
646480297	363	29.75	182	336	3	160	3.0e-16	79.4	COG0723	Rieske Fe-S protein	177
646480298	439	53.92	1	433	1	427	0.0e+00	557	COG0151	Phosphoribosylamine-glycine ligase	428
646480299	210	25	49	194	7	152	5.0e-08	51.5	COG3688	Predicted RNA-binding protein containing a PIN domain	173
646480305	252	39.16	86	249	1	155	3.0e-33	135	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
646480306	311	39.58	31	311	4	286	4.0e-66	245	COG0812	UDP-N-acetylenolpyruvoylglucosamine reductase	291
646480309	395	44.24	10	390	3	381	3.0e-115	408	COG0075	Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG	383
646480316	1343	21.24	770	1106	100	398	3.0e-17	85.1	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646480317	351	39.94	3	348	5	348	2.0e-77	282	COG2055	Malate/lactate/ureidoglycolate dehydrogenase, LDH2 family	349
646480318	318	44.51	20	317	7	311	3.0e-85	308	COG0275	16S rRNA C1402 N4-methylase RsmH	314
646480319	378	24.02	10	377	2	381	2.0e-31	130	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646480320	349	49.71	4	349	3	343	5.0e-115	407	COG0809	S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase)	348
646480321	541	25.68	190	470	51	335	2.0e-25	110	COG1566	Multidrug resistance efflux pump	352
646480322	235	47.75	7	227	1	222	1.0e-72	266	COG1136	ABC-type lipoprotein export system, ATPase component	226
646480323	417	15.55	16	415	2	418	2.0e-10	60.9	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
646480324	458	22.14	47	458	17	406	2.0e-15	77.2	COG4591	ABC-type transport system, involved in lipoprotein release, permease component	408
646480326	665	48.71	26	641	1	589	0.0e+00	616	COG0465	ATP-dependent Zn proteases	596
646480327	375	38.51	76	366	2	285	8.0e-74	271	COG1162	Putative ribosome biogenesis GTPase RsgA	301
646480328	405	55.75	7	402	3	381	0.0e+00	475	COG1104	Cysteine sulfinate desulfinase/cysteine desulfurase or related enzyme	386
646480329	110	37.96	1	108	3	108	1.0e-21	94.9	COG0316	Fe-S cluster assembly iron-binding protein IscA	110
646480332	327	38.96	23	319	19	323	7.0e-68	250	COG1052	Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase	324
646480333	411	32.54	4	209	2	210	3.0e-39	156	COG2241	Precorrin-6B methylase 1	210
646480334	301	28.27	24	300	32	312	7.0e-31	128	COG0657	Acetyl esterase/lipase	312
646480336	287	62.9	40	287	7	253	5.0e-121	427	COG1117	ABC-type phosphate transport system, ATPase component	253
646480337	310	21.74	55	302	3	274	2.0e-09	56.8	COG1082	Sugar phosphate isomerase/epimerase	274
646480339	495	17.26	4	350	1	328	3.0e-12	66.8	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646480340	271	25.1	12	253	13	263	8.0e-21	94.5	COG1082	Sugar phosphate isomerase/epimerase	274
646480341	112	62.5	1	112	1	112	2.0e-32	130	COG0347	Nitrogen regulatory protein PII	112
646480344	350	22.39	22	152	9	139	1.0e-07	50.8	COG2165	Type II secretory pathway, pseudopilin PulG	149
646480347	295	22.67	1	147	1	147	6.0e-07	48.5	COG2165	Type II secretory pathway, pseudopilin PulG	149
646480354	485	30.3	79	423	22	376	4.0e-33	136	COG1921	Seryl-tRNA(Sec) selenium transferase	395
646480361	220	29.46	72	199	19	145	3.0e-12	65.7	COG1403	5-methylcytosine-specific restriction endonuclease McrA	146
646480362	90	38.18	15	65	14	68	1.0e-05	41.7	COG1146	NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit	68
646480363	189	25.66	5	153	4	136	2.0e-11	62.6	COG0262	Dihydrofolate reductase	167
646480365	192	25.68	7	185	2	174	2.0e-13	69.3	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646480369	850	44.86	12	356	1	347	3.0e-89	323	COG0826	Collagenase-like protease, PrtC family	347
646480370	499	25.15	6	498	4	499	3.0e-77	283	COG1070	Sugar (pentulose or hexulose) kinase	502
646480371	348	27.58	1	348	3	340	4.0e-44	172	COG0673	Predicted dehydrogenase	342
646480376	303	29.93	16	273	31	308	1.0e-32	133	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
646480378	404	26.8	1	397	1	361	3.0e-50	192	COG1260	Myo-inositol-1-phosphate synthase	362
646480379	397	59.45	1	397	1	396	0.0e+00	575	COG1448	Aspartate/tyrosine/aromatic aminotransferase	396
646480383	565	43.62	1	527	2	516	2.0e-125	443	COG0459	Chaperonin GroEL (HSP60 family)	524
646480384	99	60.42	4	99	1	96	5.0e-29	119	COG0234	Co-chaperonin GroES (HSP10)	96
646480385	539	44.14	1	531	2	521	1.0e-125	443	COG0459	Chaperonin GroEL (HSP60 family)	524
646480386	383	52.17	4	367	3	369	4.0e-122	431	COG0484	DnaJ-class molecular chaperone with C-terminal Zn finger domain	371
646480387	177	42.68	12	174	30	193	6.0e-38	150	COG0576	Molecular chaperone GrpE (heat shock protein)	193
646480388	113	43.42	1	76	8	81	7.0e-11	59.3	COG2331	Predicted nucleic acid-binding protein, contains Zn-ribbon domain	82
646480389	71	37.29	1	58	5	63	9.0e-07	45	COG3024	Endogenous inhibitor of DNA gyrase, YacG/DUF329 family	65
646480392	384	25.82	45	331	1	272	5.0e-25	109	COG0515	Serine/threonine protein kinase	384
646480394	410	46.33	3	340	6	346	4.0e-91	328	COG1171	Threonine dehydratase	347
646480399	295	48.66	4	295	1	297	5.0e-83	301	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646480401	459	40.4	9	456	11	448	1.0e-89	323	COG2239	Mg/Co/Ni transporter MgtE (contains CBS domain)	451
646480402	477	25.64	23	464	19	448	1.0e-39	158	COG1797	Cobyrinic acid a,c-diamide synthase	451
646480414	286	22.78	63	280	60	296	3.0e-13	69.4	COG1073	Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family	299
646480421	416	25.98	21	292	74	329	7.0e-20	91.9	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646480421	416	35.92	301	403	21	123	2.0e-16	80.3	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646480424	302	28.86	6	295	1	274	4.0e-32	132	COG0388	Predicted amidohydrolase	274
646480426	419	16.4	50	406	45	350	7.0e-09	55.6	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646480429	287	36.84	16	280	2	263	1.0e-63	236	COG1352	Methylase of chemotaxis methyl-accepting proteins	268
646480430	367	45.66	3	358	1	350	3.0e-90	325	COG2201	Chemotaxis response regulator CheB, contains REC and protein-glutamate methylesterase domains	350
646480432	585	32.93	262	584	74	407	8.0e-39	155	COG0840	Methyl-accepting chemotaxis protein	408
646480433	147	35.97	1	139	14	152	2.0e-27	114	COG0835	Chemotaxis signal transduction protein	165
646480436	218	43.85	11	197	7	193	1.0e-52	199	COG4566	Two-component response regulator, FixJ family, consists of REC and HTH domains	202
646480437	493	24.38	4	459	1	484	2.0e-34	140	COG1008	NADH:ubiquinone oxidoreductase subunit 4 (chain M)	497
646480439	1038	28.68	236	999	133	869	2.0e-104	374	COG3002	Uncharacterized conserved protein YbcC, UPF0753/DUF2309 family	880
646480440	755	59.82	422	752	1	329	1.0e-123	437	COG0620	Methionine synthase II (cobalamin-independent)	330
646480441	473	21.05	84	401	16	287	3.0e-12	67.2	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646480451	253	42.79	19	238	1	221	1.0e-63	236	COG1136	ABC-type lipoprotein export system, ATPase component	226
646480452	384	14.7	17	384	2	416	1.0e-16	81.3	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
646480453	349	23.49	71	343	64	338	1.0e-17	84.2	COG1566	Multidrug resistance efflux pump	352
646480454	209	22.78	7	186	13	187	2.0e-10	59.3	COG1309	DNA-binding transcriptional regulator, AcrR family	201
646480456	431	30.36	122	411	13	307	2.0e-34	140	COG3458	Cephalosporin-C deacetylase or related acetyl esterase	321
646480459	614	45.99	4	593	3	553	0.0e+00	570	COG2192	Predicted carbamoyl transferase, NodU family	555
646480464	129	31.45	1	124	5	116	3.0e-14	70.7	COG2149	Uncharacterized membrane protein YidH, DUF202 family	120
646480465	291	58.05	1	291	1	294	5.0e-99	354	COG2321	Predicted metalloprotease	295
646480466	223	30	1	198	3	203	6.0e-30	124	COG3485	Protocatechuate 3,4-dioxygenase beta subunit	226
646480470	335	37.07	1	315	14	326	1.0e-62	234	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
646480473	144	21.6	18	141	11	125	3.0e-08	51.2	COG0727	Fe-S-cluster containining protein	132
646480474	180	42.86	57	147	2	92	9.0e-22	96.7	COG0776	Bacterial nucleoid DNA-binding protein	94
646480476	315	38.96	12	310	1	308	8.0e-65	240	COG0167	Dihydroorotate dehydrogenase	310
646480477	321	45.66	1	302	6	314	4.0e-87	314	COG0180	Tryptophanyl-tRNA synthetase	314
646480478	189	31.93	32	189	3	153	4.0e-14	71.4	COG1225	Peroxiredoxin	157
646480480	863	35.16	14	858	49	840	0.0e+00	573	COG1643	HrpA-like RNA helicase	845
646480482	370	26.49	26	360	21	334	1.0e-24	107	COG1466	DNA polymerase III, delta subunit	334
646480485	200	48.09	13	195	4	182	2.0e-55	208	COG0194	Guanylate kinase	191
646480486	294	35.93	1	294	1	290	1.0e-57	216	COG1561	Uncharacterized conserved protein YicC, UPF0701 family	290
646480487	206	33.82	15	81	2	68	3.0e-09	55.6	COG1314	Preprotein translocase subunit SecG	86
646480488	252	54.72	1	252	1	250	2.0e-76	279	COG0149	Triosephosphate isomerase	251
646480489	349	54.48	58	335	8	286	1.0e-98	353	COG2876	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	286
646480490	269	48.5	2	267	1	265	3.0e-68	252	COG0345	Pyrroline-5-carboxylate reductase	266
646480492	162	57.14	5	158	4	157	5.0e-53	200	COG0315	Molybdenum cofactor biosynthesis enzyme	157
646480493	349	37.46	34	349	3	322	2.0e-69	256	COG0142	Geranylgeranyl pyrophosphate synthase	322
646480495	375	31.1	7	375	4	371	3.0e-85	309	COG0075	Archaeal aspartate aminotransferase or a related aminotransferase, includes purine catabolism protein PucG	383
646480496	815	36.3	416	815	1	379	4.0e-88	319	COG0404	Glycine cleavage system T protein (aminomethyltransferase)	379
646480499	223	33.33	19	206	14	187	1.0e-26	113	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
646480500	192	36.81	1	182	1	176	2.0e-44	172	COG1791	Acireductone dioxygenase (methionine salvage), cupin superfamily	181
646480501	230	45.78	5	228	4	227	8.0e-63	233	COG4229	Enolase-phosphatase E1 involved in merthionine salvage	229
646480505	455	39.77	24	375	5	329	2.0e-77	283	COG1005	NADH:ubiquinone oxidoreductase subunit 1 (chain H)	332
646480506	370	32.98	23	210	2	166	2.0e-09	57.2	COG0839	NADH:ubiquinone oxidoreductase subunit 6 (chain J)	166
646480507	111	45.19	8	111	2	100	6.0e-19	85.9	COG0713	NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K)	100
646480512	264	44.4	4	260	1	256	4.0e-74	271	COG0084	Tat protein secretion system quality control protein TatD (DNase activity)	256
646480513	352	44.61	5	347	6	300	4.0e-81	295	COG0492	Thioredoxin reductase	305
646480514	224	36.89	11	215	1	204	1.0e-34	140	COG0586	Uncharacterized membrane protein DedA, SNARE-associated domain	208
646480516	462	44.73	1	462	3	435	0.0e+00	509	COG0017	Aspartyl/asparaginyl-tRNA synthetase	435
646480517	143	32.11	27	133	5	109	1.0e-11	62.6	COG0607	Rhodanese-related sulfurtransferase	110
646480518	371	50.79	4	371	15	390	9.0e-113	400	COG0372	Citrate synthase	390
646480519	293	52.94	1	288	2	289	3.0e-84	305	COG2513	2-Methylisocitrate lyase and related enzymes, PEP mutase family	289
646480522	335	50.44	1	334	2	342	8.0e-114	403	COG0002	N-acetyl-gamma-glutamylphosphate reductase	349
646480523	396	48.24	1	396	10	404	4.0e-116	411	COG1364	N-acetylglutamate synthase (N-acetylornithine aminotransferase)	404
646480525	297	19.35	41	294	3	274	2.0e-12	66.4	COG1082	Sugar phosphate isomerase/epimerase	274
646480526	363	28.65	1	348	1	322	6.0e-50	191	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
646480527	361	32.29	1	348	2	342	5.0e-58	218	COG0673	Predicted dehydrogenase	342
646480529	210	28.87	22	210	9	190	1.0e-19	90.1	COG0558	Phosphatidylglycerophosphate synthase	192
646480530	465	38.43	18	460	4	436	2.0e-121	429	COG0621	tRNA A37 methylthiotransferase MiaB	437
646480535	570	26.1	269	557	52	336	9.0e-33	135	COG0642	Signal transduction histidine kinase	336
646480537	216	30.23	3	216	2	207	4.0e-28	118	COG0135	Phosphoribosylanthranilate isomerase	208
646480541	488	49.07	113	484	46	420	2.0e-124	440	COG1158	Transcription termination factor Rho	422
646480543	237	47.37	18	169	5	154	4.0e-36	144	COG1321	Mn-dependent transcriptional regulator, DtxR family	154
646480544	317	42.68	3	314	2	312	1.0e-71	263	COG3252	Methenyltetrahydromethanopterin cyclohydrolase	314
646480545	298	29.87	1	297	31	317	2.0e-39	156	COG0189	Glutathione synthase/RimK-type ligase, ATP-grasp superfamily	318
646480546	562	24.65	1	556	6	527	4.0e-55	209	COG0318	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II	534
646480547	367	24.26	1	360	1	346	5.0e-27	115	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
646480548	369	27.37	1	333	1	337	7.0e-34	138	COG0673	Predicted dehydrogenase	342
646480549	268	46.56	5	251	6	252	6.0e-76	277	COG1043	Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase	260
646480550	286	39.35	1	273	3	276	3.0e-68	252	COG0774	UDP-3-O-acyl-N-acetylglucosamine deacetylase	300
646480554	664	31.8	315	572	3	220	9.0e-32	132	COG0171	NH3-dependent NAD+ synthetase	268
646480556	229	33.68	1	188	3	191	3.0e-32	132	COG4221	NADP-dependent 3-hydroxy acid dehydrogenase YdfG	246
646480558	431	29.97	143	427	84	365	7.0e-41	161	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
646480561	291	31.58	8	288	34	307	2.0e-38	153	COG3509	Poly(3-hydroxybutyrate) depolymerase	312
646480563	96	34.48	10	95	5	91	3.0e-15	73.3	COG1254	Acylphosphatase	92
646480566	482	23.03	5	325	2	330	7.0e-13	69.1	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480568	185	37.8	3	166	16	178	7.0e-26	110	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646480570	503	43.56	1	487	1	475	0.0e+00	485	COG0297	Glycogen synthase	487
646480571	386	31.71	12	369	2	328	1.0e-57	217	COG1085	Galactose-1-phosphate uridylyltransferase	338
646480572	725	15.4	5	555	4	497	2.0e-17	85.1	COG1449	Alpha-amylase/alpha-mannosidase, GH57 family	615
646480573	211	33.82	1	203	2	202	7.0e-37	147	COG1182	FMN-dependent NADH-azoreductase	202
646480574	175	36.91	8	154	7	145	3.0e-26	111	COG1959	DNA-binding transcriptional regulator, IscR family	150
646480575	266	33.8	32	243	3	206	6.0e-41	161	COG0132	Dethiobiotin synthetase	223
646480578	1068	23.59	72	417	1	370	3.0e-35	144	COG0515	Serine/threonine protein kinase	384
646480582	358	42.2	23	340	10	326	8.0e-66	244	COG0714	MoxR-like ATPase	329
646480590	616	30.45	3	351	1	346	6.0e-43	169	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480591	340	30.64	10	338	14	337	1.0e-22	100	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480592	652	28.37	7	335	7	344	5.0e-28	119	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480594	3644	24.09	1959	2352	1	410	9.0e-06	48.4	COG2931	Ca2+-binding protein, RTX toxin-related	510
646480595	147	54.93	3	141	1	142	9.0e-50	189	COG0652	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family	158
646480597	495	33.64	156	483	29	334	5.0e-42	166	COG0642	Signal transduction histidine kinase	336
646480598	223	45.18	1	222	1	227	2.0e-61	228	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646480599	558	26.09	16	531	17	517	3.0e-62	233	COG0659	Sulfate permease or related transporter, MFS superfamily	554
646480600	279	32.58	13	275	5	262	1.0e-49	190	COG0005	Purine nucleoside phosphorylase	262
646480601	303	36.57	34	298	1	260	9.0e-58	217	COG0005	Purine nucleoside phosphorylase	262
646480606	182	38.12	12	178	4	184	1.0e-23	102	COG0693	Putative intracellular protease/amidase	188
646480607	261	33.19	26	257	11	212	2.0e-25	110	COG3132	Uncharacterized conserved protein YceH, UPF0502 family	215
646480608	234	47.44	8	220	1	212	5.0e-63	234	COG2360	Leu/Phe-tRNA-protein transferase	221
646480609	480	39.63	152	475	23	339	6.0e-58	218	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646480610	318	24.83	17	300	24	304	5.0e-34	138	COG1560	Lauroyl/myristoyl acyltransferase	308
646480611	108	29.41	5	103	5	106	7.0e-15	72.3	COG2146	Ferredoxin subunit of nitrite reductase or a ring-hydroxylating dioxygenase	106
646480614	719	32.98	410	678	2	280	1.0e-41	164	COG0515	Serine/threonine protein kinase	384
646480615	1043	39.58	9	1039	1	877	0.0e+00	941	COG0525	Valyl-tRNA synthetase	877
646480616	533	34.67	11	433	1	409	4.0e-94	339	COG0119	Isopropylmalate/homocitrate/citramalate synthases	409
646480619	352	39.71	7	349	6	351	5.0e-85	308	COG1363	Putative aminopeptidase FrvX	355
646480623	177	30.3	8	172	11	175	9.0e-25	106	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646480630	645	35.59	106	636	29	543	1.0e-104	374	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
646480631	362	21.26	14	308	2	270	7.0e-32	131	COG1442	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase	325
646480632	350	20.48	5	294	3	266	3.0e-30	126	COG1442	Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase	325
646480634	532	20.1	7	204	1	208	1.0e-13	72.1	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646480636	1125	34.59	4	1057	13	933	0.0e+00	873	COG0060	Isoleucyl-tRNA synthetase	933
646480637	206	42.08	7	205	3	198	5.0e-47	181	COG0299	Folate-dependent phosphoribosylglycinamide formyltransferase PurN	200
646480639	267	39.37	5	256	1	253	1.0e-62	233	COG1349	DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family	253
646480640	235	42.92	7	225	1	208	9.0e-53	200	COG4869	Propanediol utilization protein	210
646480643	394	43.36	1	394	1	395	2.0e-114	406	COG0282	Acetate kinase	396
646480644	104	48.39	1	93	1	87	1.0e-17	81.1	COG4576	Carboxysome shell and ethanolamine utilization microcompartment protein CcmK/EutM	89
646480645	479	25.12	41	452	39	448	1.0e-40	161	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646480646	85	43.53	1	85	1	83	5.0e-11	59.2	COG4576	Carboxysome shell and ethanolamine utilization microcompartment protein CcmK/EutM	89
646480648	94	30	1	90	1	85	1.0e-07	48.4	COG4576	Carboxysome shell and ethanolamine utilization microcompartment protein CcmK/EutM	89
646480649	287	30.09	1	212	2	217	1.0e-40	160	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
646480650	314	41.94	1	306	1	307	1.0e-77	283	COG0039	Malate/lactate dehydrogenase	313
646480653	560	50.35	1	559	5	571	0.0e+00	708	COG0129	Dihydroxyacid dehydratase/phosphogluconate dehydratase	575
646480654	516	36.18	1	295	3	300	2.0e-67	250	COG1732	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein)	300
646480654	516	52.06	314	507	23	216	2.0e-56	213	COG1174	ABC-type proline/glycine betaine transport system, permease component	221
646480655	251	41.98	1	242	1	243	6.0e-73	267	COG1125	ABC-type proline/glycine betaine transport system, ATPase component	309
646480661	469	22.27	16	458	2	414	9.0e-47	181	COG1239	Mg-chelatase subunit ChlI	423
646480664	461	31.56	14	454	6	447	1.0e-64	241	COG5002	Signal transduction histidine kinase	459
646480665	1172	18.79	184	598	16	396	2.0e-11	65.4	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646480667	247	28.7	4	208	3	213	2.0e-14	73.1	COG1891	Uncharacterized protein, UPF0264 family	235
646480672	165	34.23	16	160	12	159	2.0e-26	112	COG1871	Chemotaxis receptor (MCP) glutamine deamidase CheD	164
646480673	174	20	5	174	34	201	1.0e-11	62.7	COG1776	Chemotaxis protein CheY-P-specific phosphatase CheC	203
646480674	987	32.87	194	976	1	709	0.0e+00	490	COG0643	Chemotaxis protein histidine kinase CheA	716
646480675	282	35.87	12	282	1	268	4.0e-62	231	COG1352	Methylase of chemotaxis methyl-accepting proteins	268
646480676	708	36.27	325	707	1	408	8.0e-48	185	COG0840	Methyl-accepting chemotaxis protein	408
646480677	162	43.95	6	162	2	158	7.0e-37	146	COG0835	Chemotaxis signal transduction protein	165
646480684	318	43.93	1	310	8	328	7.0e-69	254	COG0714	MoxR-like ATPase	329
646480685	435	20.55	3	432	9	391	3.0e-21	96.8	COG1721	Uncharacterized conserved protein, DUF58 family, contains vWF domain	416
646480688	654	39.09	51	641	1	567	6.0e-127	448	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
646480692	189	26.52	11	182	2	174	2.0e-07	49.3	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646480693	1122	31.49	103	389	1	305	1.0e-42	169	COG0515	Serine/threonine protein kinase	384
646480697	303	33.22	1	293	1	290	6.0e-51	194	COG0329	Dihydrodipicolinate synthase/N-acetylneuraminate lyase	299
646480698	770	30.93	435	706	2	285	3.0e-36	147	COG0515	Serine/threonine protein kinase	384
646480699	352	41.39	13	320	7	335	4.0e-92	331	COG3049	Penicillin V acylase or related amidase, Ntn superfamily	353
646480701	895	38.21	8	729	6	707	0.0e+00	542	COG0643	Chemotaxis protein histidine kinase CheA	716
646480702	144	37.31	1	134	14	147	1.0e-28	119	COG0835	Chemotaxis signal transduction protein	165
646480703	640	34.76	289	605	81	408	2.0e-34	140	COG0840	Methyl-accepting chemotaxis protein	408
646480705	372	47.69	4	349	1	332	4.0e-85	308	COG2201	Chemotaxis response regulator CheB, contains REC and protein-glutamate methylesterase domains	350
646480706	282	42.7	14	279	4	267	5.0e-71	261	COG1352	Methylase of chemotaxis methyl-accepting proteins	268
646480710	352	19.24	24	318	5	305	5.0e-06	45.5	COG1216	Glycosyltransferase, GT2 family	305
646480713	399	32.08	6	373	1	361	5.0e-58	218	COG0349	Ribonuclease D	361
646480714	266	48.06	10	266	7	261	1.0e-70	260	COG0434	Predicted TIM-barrel enzyme	263
646480715	278	33.94	6	277	1	258	3.0e-46	178	COG0566	tRNA G18 (ribose-2'-O)-methylase SpoU	260
646480716	107	46.67	1	105	2	105	3.0e-17	80.1	COG2076	Multidrug transporter EmrE and related cation transporters	106
646480718	258	22.5	19	250	34	269	3.0e-07	49.5	COG3267	Type II secretory pathway, component ExeA (predicted ATPase)	269
646480719	236	39.15	4	230	5	239	3.0e-45	175	COG1385	16S rRNA U1498 N3-methylase RsmE	246
646480725	142	32.41	9	142	8	152	1.0e-11	62.7	COG0589	Nucleotide-binding universal stress protein,  UspA family	154
646480727	354	36.75	4	334	1	322	7.0e-60	224	COG0042	tRNA-dihydrouridine synthase	323
646480729	429	21.75	50	426	1	362	3.0e-12	66.8	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646480730	562	34.83	9	512	3	512	2.0e-102	366	COG0661	Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family	517
646480732	446	23.51	50	388	3	325	2.0e-27	117	COG0673	Predicted dehydrogenase	342
646480733	609	58.47	3	602	2	603	0.0e+00	812	COG1217	Predicted membrane GTPase involved in stress response	603
646480738	508	27.7	61	323	61	313	1.0e-22	101	COG1181	D-alanine-D-alanine ligase and related ATP-grasp enzymes	317
646480739	342	27.42	37	322	28	316	2.0e-35	143	COG1181	D-alanine-D-alanine ligase and related ATP-grasp enzymes	317
646480741	436	48.91	71	435	1	366	6.0e-127	447	COG1509	L-lysine 2,3-aminomutase (EF-P beta-lysylation pathway)	369
646480746	464	46.08	28	446	32	457	2.0e-123	436	COG1139	L-lactate utilization protein LutB, contains a ferredoxin-type domain	459
646480747	192	24.74	2	192	38	218	1.0e-12	66.9	COG1556	L-lactate utilization protein LutC, contains LUD domain	218
646480749	546	49.62	11	530	8	527	0.0e+00	670	COG4108	Peptide chain release factor RF-3	528
646480751	429	18.44	25	292	52	318	1.0e-07	51.4	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646480752	740	25.31	150	534	1	357	3.0e-25	111	COG0515	Serine/threonine protein kinase	384
646480754	269	26.71	1	266	11	302	2.0e-27	116	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
646480755	204	30	4	203	1	180	7.0e-14	70.5	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646480757	422	23.1	15	284	1	247	1.0e-22	101	COG2041	Periplasmic DMSO/TMAO reductase YedYZ, molybdopterin-dependent catalytic subunit	271
646480769	435	26.38	55	379	65	393	2.0e-38	153	COG4268	5-methylcytosine-specific restriction endonuclease McrBC, regulatory subunit McrC	439
646480784	1845	21.29	10	815	3	753	1.0e-63	239	COG1205	ATP-dependent helicase YprA,  contains C-terminal metal-binding DUF1998 domain	851
646480809	208	29.44	1	208	15	228	1.0e-23	102	COG1802	DNA-binding transcriptional regulator, GntR family	230
646480810	204	29.85	4	204	2	179	2.0e-14	72.4	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646480811	744	27.84	90	406	1	287	3.0e-35	144	COG0515	Serine/threonine protein kinase	384
646480812	636	21.11	177	561	49	426	3.0e-23	103	COG5337	Spore coat protein CotH	473
646480816	395	22.66	12	386	10	395	6.0e-16	78.9	COG1819	UDP:flavonoid glycosyltransferase YjiC, YdhE family	406
646480819	418	32.76	81	241	31	203	1.0e-13	71.6	COG4798	Predicted methyltransferase	238
646480822	318	31.25	11	311	10	311	4.0e-32	132	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646480823	323	29.14	1	318	1	313	2.0e-50	193	COG0667	Predicted oxidoreductase (related to aryl-alcohol dehydrogenase)	316
646480826	305	23.2	29	148	2	125	3.0e-06	46.1	COG4319	Ketosteroid isomerase homolog	137
646480828	408	45.89	21	397	128	496	1.0e-103	370	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646480829	118	20.18	1	109	3	110	3.0e-06	43.9	COG1366	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	117
646480830	376	25.98	14	375	14	385	6.0e-32	132	COG1680	CubicO group peptidase, beta-lactamase class C family	390
646480831	432	22.07	42	392	3	328	4.0e-30	126	COG0673	Predicted dehydrogenase	342
646480832	359	22.14	85	352	67	297	2.0e-13	70.3	COG2382	Enterochelin esterase or related enzyme	299
646480833	225	26.4	28	224	25	213	5.0e-26	111	COG3295	Uncharacterized protein	213
646480834	522	31.27	1	332	3	335	1.0e-56	214	COG1477	Thiamine biosynthesis lipoprotein ApbE	337
646480835	731	21.53	32	321	30	362	2.0e-06	48.4	COG3055	N-acetylneuraminic acid mutarotase	381
646480836	889	20.18	1	436	8	398	2.0e-09	58.1	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646480841	397	24.58	71	397	60	402	6.0e-13	69	COG2319	WD40 repeat	466
646480850	234	34.08	1	220	8	226	1.0e-29	123	COG1802	DNA-binding transcriptional regulator, GntR family	230
646480865	184	27.71	19	181	15	180	1.0e-12	66.6	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646480866	559	22.13	48	373	21	365	4.0e-27	116	COG1680	CubicO group peptidase, beta-lactamase class C family	390
646480868	248	32.33	7	236	9	226	4.0e-18	85.3	COG2836	Sulfite exporter TauE/SafE	232
646480869	734	39.31	36	697	68	707	0.0e+00	521	COG2217	Cation transport ATPase	713
646480873	496	29.08	22	480	12	467	4.0e-60	226	COG3278	Cbb3-type cytochrome oxidase, subunit 1	482
646480876	312	53.44	182	309	1	129	7.0e-37	147	COG5649	Uncharacterized protein	132
646480878	299	26.03	153	294	7	147	6.0e-12	65.1	COG3832	Uncharacterized conserved protein YndB, AHSA1/START domain	149
646480879	117	33.03	1	107	1	109	3.0e-09	54	COG0640	DNA-binding transcriptional regulator, ArsR family	110
646480880	435	21.96	45	411	3	342	1.0e-23	104	COG0673	Predicted dehydrogenase	342
646480883	276	33.45	1	267	2	289	1.0e-53	203	COG0384	Predicted epimerase YddE/YHI9, PhzF superfamily	291
646480884	301	25.17	1	275	1	290	2.0e-21	96.1	COG0657	Acetyl esterase/lipase	312
646480886	205	36.59	7	201	6	202	2.0e-31	129	COG4112	Predicted phosphoesterase, NUDIX family	203
646480887	304	31.9	72	286	23	243	2.0e-33	136	COG3622	Hydroxypyruvate isomerase	260
646480888	859	41.7	117	854	3	708	0.0e+00	616	COG2217	Cation transport ATPase	713
646480889	415	40.93	1	234	2	232	7.0e-61	228	COG1058	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	255
646480895	922	47.95	10	586	1	544	0.0e+00	585	COG0550	DNA topoisomerase IA	570
646480896	135	46.4	3	127	2	126	4.0e-36	143	COG0736	Phosphopantetheinyl transferase (holo-ACP synthase)	127
646480897	331	25.63	1	310	31	336	2.0e-29	123	COG0642	Signal transduction histidine kinase	336
646480898	862	25.57	47	759	21	753	4.0e-95	343	COG0308	Aminopeptidase N	859
646480901	144	28.89	12	130	3	137	2.0e-09	55.2	COG0346	Catechol 2,3-dioxygenase or other lactoylglutathione lyase family enzyme	138
646480903	160	24.49	1	146	11	150	8.0e-14	70	COG0456	Ribosomal protein S18 acetylase RimI and related acetyltransferases	177
646480904	227	40.1	15	208	13	202	1.0e-37	149	COG0062	NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate epimerase domain	203
646480907	308	24.77	52	255	34	246	7.0e-06	45	COG5607	CHAD domain (function unknown)	283
646480908	166	31.33	4	150	1	150	8.0e-28	116	COG2062	Phosphohistidine phosphatase SixA	163
646480909	705	48.16	7	680	10	686	0.0e+00	759	COG0855	Polyphosphate kinase	696
646480910	526	27.87	15	515	1	488	7.0e-64	238	COG0248	Exopolyphosphatase/pppGpp-phosphohydrolase	492
646480911	330	33.44	11	321	9	305	4.0e-47	181	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646480912	829	24.17	520	727	54	257	1.0e-09	59.2	COG5010	Flp pilus assembly protein TadD, contains TPR repeats	257
646480913	573	20.83	4	497	1	439	5.0e-44	172	COG1232	Protoporphyrinogen oxidase	444
646480914	174	24.64	23	156	1	138	2.0e-09	55.7	COG2246	Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose)	139
646480915	261	34.4	8	255	7	247	9.0e-43	167	COG1191	DNA-directed RNA polymerase specialized sigma subunit	247
646480917	270	24	26	268	2	250	3.0e-20	92.7	COG0455	MinD-like ATPase involved in chromosome partitioning or flagellar assembly	262
646480918	417	32.04	1	410	1	394	8.0e-66	244	COG1419	Flagellar biosynthesis GTPase FlhF	407
646480919	690	47.38	1	684	12	693	0.0e+00	728	COG1298	Flagellar biosynthesis pathway, component FlhA	696
646480921	247	27.36	1	210	5	214	2.0e-32	133	COG2121	Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily	214
646480922	265	24.8	10	262	1	226	1.0e-15	76.9	COG1011	FMN phosphatase YigB, HAD superfamily	229
646480924	387	50.91	6	387	2	382	0.0e+00	483	COG0743	1-deoxy-D-xylulose 5-phosphate reductoisomerase	385
646480925	700	55.39	130	669	54	593	0.0e+00	618	COG0465	ATP-dependent Zn proteases	596
646480927	541	23.52	10	479	14	453	7.0e-29	122	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
646480929	133	25	1	120	1	95	1.0e-06	45.8	COG0633	Ferredoxin	102
646480930	110	47	1	100	1	100	2.0e-20	91	COG0347	Nitrogen regulatory protein PII	112
646480931	1040	27.55	78	1001	28	947	2.0e-111	397	COG1391	Glutamine synthetase adenylyltransferase	963
646480932	524	47.35	209	524	22	342	1.0e-77	284	COG0568	DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)	342
646480934	264	42.13	5	251	2	251	5.0e-39	154	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646480937	1177	25.65	2	1112	1	1002	0.0e+00	609	COG0841	Multidrug efflux pump subunit AcrB	1009
646480939	192	31.4	19	138	5	125	2.0e-10	58.8	COG1846	DNA-binding transcriptional regulator, MarR family	126
646480940	489	52.03	39	430	2	394	7.0e-117	414	COG2262	50S ribosomal subunit-associated GTPase HflX	411
646480941	258	31.56	8	248	6	249	1.0e-48	187	COG0300	Short-chain dehydrogenase	265
646480944	940	30.21	480	905	42	431	2.0e-43	171	COG4964	Flp pilus assembly protein, secretin CpaC	455
646480947	210	28.92	1	201	1	197	1.0e-21	96.5	COG0632	Holliday junction resolvasome RuvABC DNA-binding subunit	201
646480948	186	44.38	17	176	1	158	7.0e-38	150	COG0817	Holliday junction resolvasome RuvABC endonuclease subunit	160
646480949	515	43.69	2	510	1	462	0.0e+00	517	COG0215	Cysteinyl-tRNA synthetase	464
646480950	158	49.36	2	157	1	156	1.0e-48	185	COG0245	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	159
646480951	345	27.84	1	333	1	290	9.0e-28	117	COG1821	Predicted ATP-dependent carboligase, ATP-grasp superfamily	307
646480952	337	36.25	1	328	3	324	1.0e-54	207	COG1548	Uncharacterized protein, hydantoinase/oxoprolinase family	330
646480953	205	29.14	10	182	3	157	2.0e-15	76.2	COG2054	Uncharacterized archaeal kinase related to aspartokinase	212
646480955	677	38.81	182	668	43	545	1.0e-111	397	COG3604	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains	550
646480957	235	24.58	1	225	3	230	2.0e-10	59.4	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646480959	345	24.79	1	339	2	341	1.0e-24	107	COG0673	Predicted dehydrogenase	342
646480965	210	34.85	13	205	37	230	1.0e-27	116	COG0204	1-acyl-sn-glycerol-3-phosphate acyltransferase	255
646480966	223	47.91	1	213	5	219	3.0e-61	228	COG0283	Cytidylate kinase	222
646480970	928	24.86	3	357	8	353	4.0e-29	123	COG4972	Tfp pilus assembly protein, ATPase PilM	354
646480973	176	54.39	8	176	7	177	6.0e-47	180	COG0503	Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein	179
646480974	246	29.08	7	246	10	248	6.0e-26	111	COG0095	Lipoate-protein ligase A	248
646480982	1275	21.69	1	1020	1	977	1.0e-66	248	COG4717	Uncharacterized protein YhaN	984
646480983	416	19.59	7	312	2	327	2.0e-16	80.6	COG0420	DNA repair exonuclease SbcCD nuclease subunit	390
646480984	309	48.26	19	306	7	276	3.0e-79	288	COG0157	Nicotinate-nucleotide pyrophosphorylase	280
646480990	361	24.4	1	360	1	354	7.0e-29	121	COG4972	Tfp pilus assembly protein, ATPase PilM	354
646480992	205	19.44	8	181	17	192	1.0e-08	53.1	COG3167	Tfp pilus assembly protein PilO	211
646480995	501	30.05	128	499	90	452	2.0e-47	183	COG5002	Signal transduction histidine kinase	459
646480997	108	22.32	1	107	3	114	3.0e-06	43.9	COG1366	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)	117
646480998	596	47.25	81	568	16	500	0.0e+00	512	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646480999	398	38.78	4	395	3	393	5.0e-88	318	COG1459	Type II secretory pathway, component PulF	397
646481001	327	44.22	15	317	2	304	5.0e-103	368	COG1242	Radical SAM superfamily enzyme	312
646481006	420	27.42	29	402	4	443	4.0e-45	176	COG3119	Arylsulfatase A or related enzyme	475
646481009	600	41.38	73	415	35	379	2.0e-76	280	COG1960	Acyl-CoA dehydrogenase related to the alkylation response protein AidB	393
646481013	380	52.17	1	380	6	394	0.0e+00	470	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
646481014	401	43.41	14	397	10	394	6.0e-116	411	COG0626	Cystathionine beta-lyase/cystathionine gamma-synthase	396
646481018	273	43.48	38	264	1	230	8.0e-60	223	COG0571	dsRNA-specific ribonuclease	235
646481019	325	35.11	2	315	24	324	9.0e-63	234	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
646481022	1314	23.75	577	1089	112	552	2.0e-47	185	COG1450	Type II secretory pathway component GspD/PulD (secretin)	587
646481028	142	33.58	7	134	3	139	1.0e-10	59.3	COG2165	Type II secretory pathway, pseudopilin PulG	149
646481029	400	37.25	1	400	1	396	8.0e-83	300	COG1459	Type II secretory pathway, component PulF	397
646481030	573	48.4	62	560	5	496	0.0e+00	526	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646481033	624	25.49	25	522	13	474	1.0e-38	155	COG1807	4-amino-4-deoxy-L-arabinose transferase or related glycosyltransferase of PMT family	535
646481034	1277	19.06	241	562	101	398	2.0e-10	62.3	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646481038	499	29.27	48	455	1	443	6.0e-59	221	COG3119	Arylsulfatase A or related enzyme	475
646481039	299	25.54	22	295	13	285	2.0e-36	146	COG1639	HD-like signal output (HDOD) domain, no enzymatic activity	289
646481042	758	36.12	14	751	4	729	0.0e+00	539	COG1529	CO or xanthine dehydrogenase, Mo-binding subunit	731
646481043	161	55.77	4	158	1	156	1.0e-50	192	COG2080	Aerobic-type carbon monoxide dehydrogenase, small subunit, CoxS/CutS family	156
646481044	297	39.24	1	288	1	283	2.0e-57	215	COG1319	CO or xanthine dehydrogenase, FAD-binding subunit	284
646481045	194	32.43	1	169	1	183	6.0e-27	113	COG0717	Deoxycytidine triphosphate deaminase	183
646481046	214	48.31	8	214	4	209	4.0e-73	267	COG0177	Endonuclease III	211
646481048	153	25.62	7	127	3	123	9.0e-17	79.5	COG3682	Predicted transcriptional regulator	123
646481049	658	25.45	16	343	3	317	5.0e-24	106	COG4219	Signal transducer regulating beta-lactamase production, contains  metallopeptidase domain	337
646481053	536	32.93	112	278	2	157	7.0e-20	92.4	COG3436	Transposase	157
646481078	475	29.63	37	442	1	443	5.0e-58	218	COG3119	Arylsulfatase A or related enzyme	475
646481080	198	36.17	8	192	2	189	1.0e-37	149	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
646481081	398	28.66	3	320	3	329	8.0e-44	171	COG0389	Nucleotidyltransferase/DNA polymerase involved in DNA repair	354
646481084	156	34.01	7	153	1	147	2.0e-33	134	COG3779	Uncharacterized conserved protein YegJ, DUF2314 family	151
646481085	541	46.27	1	533	2	524	7.0e-130	457	COG0459	Chaperonin GroEL (HSP60 family)	524
646481086	110	56.25	15	110	1	96	5.0e-29	119	COG0234	Co-chaperonin GroES (HSP10)	96
646481088	272	28.83	2	264	116	387	1.0e-34	140	COG4099	Predicted peptidase	387
646481090	268	30.21	8	99	1	96	1.0e-10	60.5	COG3293	Transposase	124
646481092	325	26.9	24	167	7	146	5.0e-08	52	COG2165	Type II secretory pathway, pseudopilin PulG	149
646481094	699	45.02	12	681	9	673	0.0e+00	714	COG1200	RecG-like helicase	677
646481098	354	48.73	5	354	1	345	6.0e-115	407	COG0473	Isocitrate/isopropylmalate dehydrogenase	348
646481099	198	33.33	32	189	7	168	8.0e-28	117	COG0350	O6-methylguanine-DNA--protein-cysteine methyltransferase	168
646481102	421	53.22	17	419	6	409	0.0e+00	479	COG1915	Uncharacterized conserved protein, contains Saccharopine dehydrogenase N-terminal (SDHN) domain	415
646481103	291	36.74	12	271	4	267	4.0e-58	218	COG1834	N-Dimethylarginine dimethylaminohydrolase	267
646481105	422	22.48	3	365	1	358	9.0e-11	61.9	COG4102	Uncharacterized conserved protein, DUF1501 family	418
646481107	197	28.48	16	169	19	176	9.0e-17	80.1	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481108	422	22.48	3	365	1	358	9.0e-11	61.9	COG4102	Uncharacterized conserved protein, DUF1501 family	418
646481111	659	39.17	102	652	29	567	4.0e-107	382	COG1132	ABC-type multidrug transport system, ATPase and permease component	567
646481112	448	28.87	7	437	8	424	4.0e-59	222	COG1253	Hemolysin or related protein, contains CBS domains	429
646481115	417	25.37	19	417	6	371	1.0e-30	127	COG4299	Predicted acyltransferase	371
646481117	205	37.31	1	200	3	195	5.0e-49	187	COG1057	Nicotinic acid mononucleotide adenylyltransferase	197
646481121	387	31.78	23	387	24	404	3.0e-65	242	COG0520	Selenocysteine lyase/Cysteine desulfurase	405
646481122	168	46.5	7	163	3	157	1.0e-47	182	COG0669	Phosphopantetheine adenylyltransferase	159
646481123	414	28.02	54	412	12	362	9.0e-21	95.2	COG1835	Peptidoglycan/LPS O-acetylase OafA/YrhL, contains acyltransferase and SGNH-hydrolase domains	386
646481124	506	42.6	1	502	3	502	2.0e-130	459	COG1070	Sugar (pentulose or hexulose) kinase	502
646481125	195	21.29	13	167	1	199	5.0e-11	61.4	COG1335	Nicotinamidase-related amidase	205
646481129	507	35.32	73	507	2	438	3.0e-70	259	COG1502	Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase or related enzyme	438
646481130	362	37.57	1	337	1	319	2.0e-74	273	COG1868	Flagellar motor switch protein FliM	332
646481131	424	58.75	9	424	1	417	0.0e+00	558	COG0014	Gamma-glutamyl phosphate reductase	417
646481132	573	36.99	229	542	52	369	7.0e-69	255	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	406
646481133	429	17.66	17	429	14	410	6.0e-14	72.2	COG1914	Mn2+ and Fe2+ transporters of the NRAMP family	416
646481134	344	44.2	9	327	3	321	6.0e-89	321	COG4586	ABC-type uncharacterized transport system, ATPase component	325
646481136	518	61.28	98	516	2	419	0.0e+00	620	COG1158	Transcription termination factor Rho	422
646481138	202	37.06	1	195	2	193	2.0e-33	135	COG0237	Dephospho-CoA kinase	201
646481139	966	50.17	361	961	3	592	0.0e+00	646	COG0749	DNA polymerase I - 3'-5' exonuclease and polymerase domains	593
646481144	279	35.52	3	261	2	254	6.0e-59	220	COG1099	Predicted metal-dependent hydrolase, TIM-barrel fold	254
646481148	300	26.53	2	269	1	290	3.0e-19	89.5	COG0524	Sugar or nucleoside kinase, ribokinase family	311
646481149	189	29.03	4	189	1	179	4.0e-29	121	COG1514	2'-5' RNA ligase	180
646481150	358	57.34	20	301	2	279	9.0e-78	284	COG0468	RecA/RadA recombinase	279
646481151	501	33.33	65	337	74	332	1.0e-32	134	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646481153	103	31.18	1	93	3	86	4.0e-12	63.1	COG1359	Quinol monooxygenase YgiN	100
646481154	391	27.3	12	370	11	268	9.0e-30	124	COG1975	Xanthine and CO dehydrogenase maturation factor, XdhC/CoxF family	278
646481155	210	23.3	6	210	8	196	3.0e-16	78.8	COG2068	CTP:molybdopterin cytidylyltransferase MocA	199
646481157	308	36.81	1	305	4	293	9.0e-70	257	COG1131	ABC-type multidrug transport system, ATPase component	293
646481160	377	39.39	41	369	5	322	1.0e-67	250	COG0598	Mg2+ and Co2+ transporter CorA	322
646481163	272	41.73	1	265	1	263	1.0e-66	246	COG0159	Tryptophan synthase alpha chain	265
646481164	409	65.47	14	404	3	392	0.0e+00	649	COG0133	Tryptophan synthase beta chain	396
646481166	284	37.46	1	276	1	273	1.0e-57	216	COG0266	Formamidopyrimidine-DNA glycosylase	273
646481167	738	27.6	441	714	25	298	2.0e-38	154	COG0668	Small-conductance mechanosensitive channel	316
646481169	578	43.96	36	577	6	539	0.0e+00	523	COG0405	Gamma-glutamyltranspeptidase	539
646481173	141	44.87	22	99	14	91	7.0e-17	79.7	COG4859	Uncharacterized protein	105
646481176	935	41.7	1	933	6	879	0.0e+00	873	COG0013	Alanyl-tRNA synthetase	879
646481178	1119	42.31	713	1101	1	388	3.0e-108	386	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
646481183	498	46.99	21	497	1	462	0.0e+00	504	COG0147	Anthranilate/para-aminobenzoate synthases component I	462
646481184	171	31.58	1	167	1	170	2.0e-24	105	COG3880	Protein-arginine kinase activator protein McsA	176
646481185	354	43.77	6	348	6	350	3.0e-86	312	COG3869	Protein-arginine kinase	352
646481188	244	45.13	26	220	2	196	3.0e-53	201	COG4566	Two-component response regulator, FixJ family, consists of REC and HTH domains	202
646481189	399	23.7	1	390	7	402	1.0e-22	101	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
646481190	369	28.21	30	315	46	349	3.0e-35	142	COG5653	Acetyltransferase involved in cellulose biosynthesis, CelD/BcsL family	406
646481191	358	26.61	1	319	29	363	2.0e-33	136	COG5653	Acetyltransferase involved in cellulose biosynthesis, CelD/BcsL family	406
646481192	367	19.42	7	287	3	304	2.0e-17	83.3	COG1216	Glycosyltransferase, GT2 family	305
646481193	457	24.46	74	432	46	405	3.0e-11	63.6	COG3307	O-antigen ligase	424
646481194	463	20.4	45	444	10	411	1.0e-15	78.2	COG2244	Membrane protein involved in the export of O-antigen and teichoic acid	480
646481196	538	16.6	11	502	14	456	2.0e-28	120	COG3206	Uncharacterized protein involved in exopolysaccharide biosynthesis	458
646481197	404	52.9	4	398	7	397	0.0e+00	518	COG0137	Argininosuccinate synthase	403
646481198	259	42.06	8	256	5	254	4.0e-58	218	COG1691	NCAIR mutase (PurE)-related protein	254
646481199	289	43.48	6	278	17	281	8.0e-59	220	COG0063	NAD(P)H-hydrate repair enzyme Nnr, NAD(P)H-hydrate dehydratase domain	284
646481200	310	39.87	1	306	1	304	2.0e-78	286	COG0196	FAD synthase	304
646481201	327	28.79	1	327	2	325	2.0e-46	179	COG0618	nanoRNase/pAp phosphatase, hydrolyzes c-di-AMP and oligoRNAs	332
646481202	205	20.77	19	195	1	175	7.0e-09	54	COG0723	Rieske Fe-S protein	177
646481203	1002	29.89	5	351	7	344	2.0e-55	211	COG1290	Cytochrome b subunit of the bc complex	381
646481210	256	48.77	11	251	2	244	2.0e-73	269	COG0846	NAD-dependent protein deacetylase, SIR2 family	250
646481218	302	26.34	81	283	29	227	3.0e-19	89.3	COG3828	Type 1 glutamine amidotransferase (GATase1)-like domain	239
646481220	970	27.04	75	456	135	505	2.0e-13	71.9	COG1404	Serine protease, subtilisin family	508
646481222	269	28.69	7	249	1	242	6.0e-35	141	COG4464	Tyrosine-protein phosphatase YwqE	254
646481223	334	36.78	1	328	2	321	6.0e-72	264	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
646481224	183	34.48	1	164	10	182	2.0e-29	122	COG1678	Putative transcriptional regulator, AlgH/UPF0301 family	194
646481225	835	27.25	488	830	2	330	4.0e-36	147	COG0642	Signal transduction histidine kinase	336
646481226	237	41.3	6	232	3	229	9.0e-49	187	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646481228	323	36.69	17	263	29	263	9.0e-44	170	COG1446	Isoaspartyl peptidase or L-asparaginase, Ntn-hydrolase superfamily	307
646481230	281	28.37	1	277	3	274	3.0e-23	102	COG1082	Sugar phosphate isomerase/epimerase	274
646481232	329	34.66	38	311	23	282	3.0e-54	205	COG1398	Fatty-acid desaturase	289
646481234	304	28.7	1	107	2	108	1.0e-09	57.4	COG2165	Type II secretory pathway, pseudopilin PulG	149
646481236	489	23.08	45	351	86	382	4.0e-09	56.6	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646481238	299	30.82	21	299	3	260	3.0e-34	139	COG3694	ABC-type uncharacterized transport system, permease component	260
646481239	271	31.8	11	271	11	268	3.0e-26	112	COG4587	ABC-type uncharacterized transport system, permease component	268
646481240	347	22.95	13	133	7	124	1.0e-07	51.2	COG2165	Type II secretory pathway, pseudopilin PulG	149
646481243	374	30.14	24	367	6	342	4.0e-46	179	COG0673	Predicted dehydrogenase	342
646481244	273	27.8	1	268	3	274	1.0e-29	123	COG1082	Sugar phosphate isomerase/epimerase	274
646481246	706	33	9	286	2	298	2.0e-44	174	COG0515	Serine/threonine protein kinase	384
646481247	202	40.78	1	202	1	205	7.0e-44	170	COG0522	Ribosomal protein S4 or related protein	205
646481248	478	47.82	1	457	3	453	0.0e+00	465	COG1249	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component or related enzyme	454
646481250	905	59.68	22	902	7	884	0.0e+00	1223	COG2609	Pyruvate dehydrogenase complex, dehydrogenase (E1) component	887
646481251	469	43.25	1	467	1	403	2.0e-95	343	COG0508	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component	404
646481255	179	24.54	16	173	6	163	2.0e-08	52.3	COG2318	Uncharacterized damage-inducible protein DinB (forms a four-helix bundle)	172
646481259	99	47.37	1	95	1	93	8.0e-27	111	COG3309	Virulence-associated protein VapD (function unknown)	96
646481260	430	41.24	1	427	3	390	9.0e-115	407	COG0448	ADP-glucose pyrophosphorylase	393
646481263	505	33.12	34	484	11	468	3.0e-79	289	COG0769	UDP-N-acetylmuramyl tripeptide synthase	475
646481266	266	40.08	11	261	4	250	9.0e-42	163	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646481269	459	36.26	18	350	8	345	2.0e-56	213	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646481270	306	37.74	12	302	14	316	1.0e-53	203	COG0611	Thiamine monophosphate kinase	317
646481271	164	35.33	4	152	1	149	8.0e-27	113	COG0802	tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE	149
646481274	498	27.23	28	469	22	447	3.0e-56	213	COG4284	UDP-N-acetylglucosamine pyrophosphorylase	472
646481275	361	34.71	1	337	1	332	4.0e-95	341	COG0836	Mannose-1-phosphate guanylyltransferase	333
646481277	153	40.3	7	139	1	134	5.0e-28	116	COG0816	RNase H-fold protein, predicted Holliday junction resolvase in Firmicutes and mycoplasms, involved in anti-termination at Rho-dependent terminators	141
646481280	379	29.76	108	377	58	341	5.0e-33	135	COG0265	Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain	347
646481282	297	21.77	7	297	8	313	4.0e-16	79.2	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646481285	260	25.21	23	251	25	252	1.0e-18	87.2	COG0491	Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II	252
646481287	177	22.89	10	174	16	181	1.0e-14	73.2	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481288	199	51.03	1	193	1	193	7.0e-72	263	COG0450	Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin)	194
646481291	670	24.47	131	666	71	617	1.0e-58	221	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
646481292	462	33.96	5	449	2	467	1.0e-80	294	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
646481293	174	50.94	15	173	14	172	1.0e-47	182	COG0663	Carbonic anhydrase or acetyltransferase, isoleucine patch superfamily	176
646481295	340	43.29	17	340	2	327	5.0e-92	331	COG0502	Biotin synthase or related enzyme	335
646481297	341	39.06	17	307	22	341	5.0e-72	264	COG1858	Cytochrome c peroxidase	364
646481298	200	57.22	1	193	1	186	6.0e-73	266	COG0066	3-isopropylmalate dehydratase small subunit	191
646481299	473	58	5	469	1	422	0.0e+00	631	COG0065	Homoaconitase/3-isopropylmalate dehydratase large subunit	423
646481300	567	31.25	266	536	2	282	4.0e-47	183	COG0515	Serine/threonine protein kinase	384
646481301	211	38.28	3	210	1	208	1.0e-39	156	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646481302	450	17.82	5	450	4	356	2.0e-13	70.9	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646481303	270	23.08	38	257	18	235	1.0e-11	64.1	COG2981	Uncharacterized protein involved in cysteine biosynthesis	250
646481304	383	28.74	47	372	32	371	9.0e-47	181	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
646481305	232	39.06	1	222	1	232	1.0e-55	209	COG0496	Broad specificity polyphosphatase and 5'/3'-nucleotidase SurE	252
646481307	334	21.78	19	226	33	256	1.0e-08	54.6	COG4785	Lipoprotein NlpI, contains TPR repeats	297
646481308	261	28.85	30	133	16	119	4.0e-13	68.8	COG5015	Uncharacterized protein, pyridoxamine 5'-phosphate oxidase (PNPOx-like) family	132
646481311	511	30.04	37	487	1	474	3.0e-50	193	COG3119	Arylsulfatase A or related enzyme	475
646481312	510	26.34	37	496	1	470	3.0e-46	180	COG3119	Arylsulfatase A or related enzyme	475
646481313	490	27	34	477	1	461	5.0e-50	192	COG3119	Arylsulfatase A or related enzyme	475
646481316	504	31.4	29	444	1	443	1.0e-58	221	COG3119	Arylsulfatase A or related enzyme	475
646481317	495	28.37	34	483	2	474	6.0e-55	208	COG3119	Arylsulfatase A or related enzyme	475
646481318	300	27.96	26	288	39	309	1.0e-25	110	COG0657	Acetyl esterase/lipase	312
646481320	532	23.32	33	532	49	538	6.0e-22	99.2	COG1178	ABC-type Fe3+ transport system, permease component	540
646481322	305	37.5	47	292	34	279	1.0e-49	190	COG0061	NAD kinase	281
646481323	643	48.64	6	625	4	621	0.0e+00	727	COG1154	Deoxyxylulose-5-phosphate synthase	627
646481324	296	39.58	5	296	1	322	2.0e-58	219	COG0142	Geranylgeranyl pyrophosphate synthase	322
646481325	127	34.62	10	87	3	78	6.0e-08	49.9	COG1722	Exonuclease VII small subunit	81
646481326	405	48.05	8	404	1	435	9.0e-121	426	COG1570	Exonuclease VII, large subunit	440
646481327	280	43.88	1	277	1	270	3.0e-82	298	COG0253	Diaminopimelate epimerase	272
646481334	519	45.74	298	519	1	222	6.0e-40	159	COG1418	HD superfamily phosphodieaserase, includes HD domain of RNase Y	222
646481335	275	45	1	259	1	259	5.0e-76	277	COG1692	Calcineurin-like phosphoesterase	266
646481341	1192	33.01	61	567	18	506	6.0e-78	286	COG0342	Preprotein translocase subunit SecD	506
646481342	138	41.84	32	129	1	94	3.0e-16	77.5	COG1862	Preprotein translocase subunit YajC	97
646481343	373	52.92	12	368	4	362	0.0e+00	466	COG0343	Queuine/archaeosine tRNA-ribosyltransferase	372
646481346	321	31.44	18	311	3	294	6.0e-38	151	COG1597	Diacylglycerol kinase family enzyme	301
646481347	285	59.26	15	284	5	274	2.0e-107	382	COG2877	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase	279
646481349	198	38.74	65	174	30	138	3.0e-15	75.4	COG1403	5-methylcytosine-specific restriction endonuclease McrA	146
646481350	328	43.4	23	324	12	329	8.0e-65	240	COG0714	MoxR-like ATPase	329
646481352	437	22.19	19	346	3	312	6.0e-26	112	COG1721	Uncharacterized conserved protein, DUF58 family, contains vWF domain	416
646481355	244	29.41	15	235	7	197	6.0e-25	108	COG0400	Predicted esterase	207
646481356	152	24.44	5	136	6	140	3.0e-11	61.4	COG2193	Bacterioferritin (cytochrome b1)	157
646481357	152	31.82	1	130	1	132	1.0e-22	99.3	COG1959	DNA-binding transcriptional regulator, IscR family	150
646481358	276	30.89	17	268	4	258	1.0e-45	176	COG0483	Archaeal fructose-1,6-bisphosphatase or related enzyme of inositol monophosphatase family	260
646481360	89	57.3	1	89	1	89	4.0e-24	102	COG0184	Ribosomal protein S15P/S13E	89
646481361	744	51.22	1	693	3	692	0.0e+00	820	COG1185	Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)	692
646481363	168	32.39	18	159	6	145	2.0e-27	115	COG0735	Fe2+ or Zn2+ uptake regulation protein	145
646481367	566	26.11	215	566	12	367	2.0e-37	150	COG2208	Serine phosphatase RsbU, regulator of sigma subunit	367
646481368	629	31.52	4	617	68	706	1.0e-122	434	COG2217	Cation transport ATPase	713
646481369	779	41.52	408	576	8	178	3.0e-41	163	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646481371	185	38.6	1	171	3	166	1.0e-34	139	COG0703	Shikimate kinase	172
646481372	495	36.27	214	489	1	280	4.0e-71	262	COG0169	Shikimate 5-dehydrogenase	283
646481373	478	47.35	17	464	6	454	0.0e+00	476	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646481376	1005	20.62	75	377	1	322	2.0e-20	95.2	COG0515	Serine/threonine protein kinase	384
646481378	227	40.29	1	204	4	205	1.0e-48	186	COG0288	Carbonic anhydrase	207
646481379	411	49.88	4	409	4	409	0.0e+00	460	COG0334	Glutamate dehydrogenase/leucine dehydrogenase	411
646481385	476	33.78	10	454	1	438	4.0e-102	365	COG0015	Adenylosuccinate lyase	438
646481386	281	41.61	6	276	1	267	5.0e-63	234	COG1912	S-adenosylmethionine hydrolase (SAM-hydroxide adenosyltransferase)	268
646481388	450	50	1	440	2	441	0.0e+00	528	COG0161	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	449
646481393	336	25	78	335	40	300	5.0e-28	118	COG2813	16S rRNA G1207 methylase RsmC	300
646481398	542	31.7	76	361	1	303	2.0e-47	183	COG0515	Serine/threonine protein kinase	384
646481399	215	27.69	10	204	2	175	1.0e-15	76.3	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481400	185	32.72	23	183	16	177	1.0e-23	102	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481404	212	31.89	16	199	4	178	6.0e-22	97.8	COG4293	Uncharacterized protein	184
646481406	464	19.9	49	434	8	339	3.0e-25	110	COG0673	Predicted dehydrogenase	342
646481408	338	61.68	63	335	13	286	3.0e-97	348	COG2876	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase	286
646481409	642	40.64	1	526	1	523	0.0e+00	504	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646481410	191	42.55	4	191	13	199	2.0e-45	175	COG4445	tRNA isopentenyl-2-thiomethyl-A-37 hydroxylase MiaE (synthesis of 2-methylthio-cis-ribozeatin)	203
646481415	474	19.6	243	441	5	179	6.0e-17	82.8	COG2849	Antitoxin component YwqK of the YwqJK toxin-antitoxin module	230
646481416	392	46.52	27	383	2	345	1.0e-88	320	COG2201	Chemotaxis response regulator CheB, contains REC and protein-glutamate methylesterase domains	350
646481417	441	20.23	9	347	6	248	7.0e-07	49.1	COG0492	Thioredoxin reductase	305
646481418	309	25.26	33	289	29	314	1.0e-18	87.4	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
646481419	271	23.12	11	209	3	152	2.0e-10	60	COG0622	Predicted phosphodiesterase	172
646481427	186	28.74	3	173	3	174	7.0e-23	100	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481428	293	27.03	13	197	1	176	8.0e-20	91.3	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481430	323	30.21	1	320	4	334	3.0e-46	179	COG1064	D-arabinose 1-dehydrogenase, Zn-dependent alcohol dehydrogenase family	339
646481431	458	45.9	29	449	5	389	4.0e-107	381	COG3004	Na+/H+ antiporter NhaA	390
646481436	562	35.26	1	562	1	587	6.0e-108	385	COG0369	Sulfite reductase, alpha subunit (flavoprotein)	587
646481437	609	32.49	115	585	45	496	3.0e-95	343	COG0155	Sulfite reductase, beta subunit (hemoprotein)	510
646481439	559	25.36	270	546	2	269	2.0e-19	91.1	COG3302	DMSO reductase anchor subunit	281
646481439	559	38.41	61	207	5	155	1.0e-39	157	COG0437	Fe-S-cluster-containing dehydrogenase component	203
646481440	303	46.25	5	257	4	245	2.0e-78	285	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
646481441	294	51.95	6	261	4	248	1.0e-77	283	COG1116	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component	248
646481442	279	39.36	31	276	11	250	2.0e-43	169	COG0600	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component	258
646481443	445	25.89	54	383	16	335	7.0e-44	171	COG0715	ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component	335
646481446	511	35.16	6	486	1	461	1.0e-83	304	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646481448	235	39.3	11	235	1	228	9.0e-57	213	COG0745	DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain	229
646481449	909	46.43	4	896	4	884	0.0e+00	918	COG2205	K+-sensing histidine kinase KdpD	890
646481450	188	57.37	1	188	1	190	3.0e-62	231	COG2156	K+-transporting ATPase, c chain	190
646481451	689	68.28	11	689	9	681	0.0e+00	982	COG2216	High-affinity K+ transport system, ATPase chain B	681
646481452	596	59.15	3	592	2	560	0.0e+00	712	COG2060	K+-transporting ATPase, A chain	560
646481456	546	30.71	28	510	1	465	1.0e-67	250	COG3119	Arylsulfatase A or related enzyme	475
646481457	513	30.02	33	471	1	457	1.0e-63	237	COG3119	Arylsulfatase A or related enzyme	475
646481458	631	28.26	51	410	4	407	1.0e-51	198	COG3119	Arylsulfatase A or related enzyme	475
646481462	1079	47.74	2	1039	1	1009	0.0e+00	1000	COG0841	Multidrug efflux pump subunit AcrB	1009
646481463	539	23.76	69	451	37	365	6.0e-27	115	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646481464	157	39.46	13	153	8	148	2.0e-25	108	COG0590	tRNA(Arg) A34 adenosine deaminase TadA	152
646481465	689	25.21	289	519	34	262	4.0e-13	70.5	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
646481467	319	42.38	4	319	2	329	2.0e-61	229	COG0714	MoxR-like ATPase	329
646481470	432	20.51	36	335	67	354	1.0e-11	64.9	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646481472	490	23.28	43	415	3	339	1.0e-24	108	COG0673	Predicted dehydrogenase	342
646481474	154	27.78	20	144	1	126	5.0e-12	63.8	COG1846	DNA-binding transcriptional regulator, MarR family	126
646481478	475	26.96	44	450	1	441	1.0e-54	208	COG3119	Arylsulfatase A or related enzyme	475
646481479	164	54.01	24	159	4	140	4.0e-54	203	COG0229	Peptide methionine sulfoxide reductase MsrB	140
646481480	214	53.37	31	193	2	164	3.0e-62	231	COG0225	Peptide methionine sulfoxide reductase MsrA	174
646481484	345	47.06	13	215	7	209	8.0e-60	224	COG0009	tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC	211
646481487	885	30.49	73	880	67	863	2.0e-127	450	COG2844	UTP:GlnB (protein PII) uridylyltransferase	867
646481488	112	63.39	1	112	1	112	2.0e-37	147	COG0347	Nitrogen regulatory protein PII	112
646481490	493	51.83	53	490	3	402	2.0e-119	423	COG0004	Ammonia channel protein AmtB	409
646481491	182	54.4	1	182	5	181	2.0e-56	211	COG2096	Cob(I)alamin adenosyltransferase	184
646481493	147	19.83	34	147	33	153	2.0e-07	48.4	COG0494	8-oxo-dGTP pyrophosphatase MutT and related house-cleaning NTP pyrophosphohydrolases, NUDIX family	161
646481498	405	31.3	3	256	1	251	6.0e-39	155	COG0476	Molybdopterin or thiamine biosynthesis adenylyltransferase	254
646481499	174	19.4	31	164	2	124	6.0e-06	44	COG1310	Proteasome lid subunit RPN8/RPN11, contains Jab1/MPN domain metalloenzyme (JAMM) motif	134
646481500	255	23.65	1	139	1	129	5.0e-09	55.3	COG5078	Ubiquitin-protein ligase	153
646481505	545	24.03	322	544	71	301	2.0e-16	81.3	COG1305	Transglutaminase-like enzyme, putative cysteine protease	319
646481506	200	38.92	22	200	3	187	1.0e-26	113	COG1670	Protein N-acetyltransferase, RimJ/RimL family	187
646481511	360	33.33	7	326	17	340	3.0e-52	198	COG0429	Predicted hydrolase of the alpha/beta-hydrolase fold	345
646481512	611	50	279	611	112	459	2.0e-102	366	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646481513	280	28.51	19	233	3	205	2.0e-13	70.1	COG2138	Sirohydrochlorin ferrochelatase	245
646481514	708	31.41	169	583	17	381	1.0e-69	258	COG0793	C-terminal processing protease CtpA/Prc, contains a PDZ domain	406
646481515	255	33.84	2	253	7	262	5.0e-35	141	COG1235	Phosphoribosyl 1,2-cyclic phosphodiesterase	269
646481516	1234	51.24	25	827	4	704	0.0e+00	833	COG0653	Preprotein translocase subunit SecA (ATPase, RNA helicase)	822
646481517	442	35.6	7	432	7	419	3.0e-92	332	COG1519	3-deoxy-D-manno-octulosonic-acid transferase	419
646481519	217	41.98	1	211	1	211	1.0e-52	199	COG0800	2-keto-3-deoxy-6-phosphogluconate aldolase	211
646481522	428	62.18	24	416	1	392	0.0e+00	599	COG1219	ATP-dependent protease Clp, ATPase subunit	408
646481529	290	24.28	37	290	9	256	1.0e-15	77.3	COG3568	Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family	259
646481534	168	34.94	1	160	10	175	9.0e-24	103	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481535	776	18.36	314	564	10	251	5.0e-07	50.3	COG1240	Mg-chelatase subunit ChlD	261
646481538	277	26.47	73	275	11	213	6.0e-20	91.6	COG0811	Biopolymer transport protein ExbB/TolQ	216
646481539	148	27.78	4	147	7	137	2.0e-10	58.7	COG0848	Biopolymer transport protein ExbD	137
646481541	314	46.15	19	314	4	300	1.0e-86	313	COG4974	Site-specific recombinase XerD	300
646481542	327	52.28	1	325	1	329	0.0e+00	471	COG1087	UDP-glucose 4-epimerase	329
646481545	201	60.49	1	201	2	202	1.0e-77	282	COG0605	Superoxide dismutase	204
646481546	1254	24.28	959	1207	12	280	3.0e-16	81.6	COG0755	ABC-type transport system involved in cytochrome c biogenesis, permease component	281
646481548	333	25.84	138	315	28	188	2.0e-08	54.1	COG2885	Outer membrane protein OmpA and related peptidoglycan-associated (lipo)proteins	190
646481552	236	31.22	12	220	7	219	3.0e-28	118	COG0603	7-cyano-7-deazaguanine synthase (queuosine biosynthesis)	222
646481553	169	32.37	28	159	2	125	7.0e-21	93.5	COG0720	6-pyruvoyl-tetrahydropterin synthase	127
646481554	506	28.83	30	493	1	464	2.0e-58	219	COG3119	Arylsulfatase A or related enzyme	475
646481555	550	23.61	4	241	18	310	2.0e-18	87.9	COG1262	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain	314
646481555	550	29.25	247	550	1	304	3.0e-35	143	COG3386	Sugar lactone lactonase YvrE	307
646481556	337	52.12	24	330	7	294	1.0e-84	306	COG4864	Uncharacterized protein YqfA, UPF0365 family	328
646481557	373	43.12	1	373	3	353	1.0e-109	389	COG0482	tRNA U34 2-thiouridine synthase MnmA/TrmU, contains the PP-loop ATPase domain	356
646481560	466	34.25	143	463	2	358	3.0e-68	253	COG0484	DnaJ-class molecular chaperone with C-terminal Zn finger domain	371
646481563	152	38.98	37	151	1	117	5.0e-14	70.7	COG0594	RNase P protein component	117
646481564	86	46.97	21	86	8	73	3.0e-20	90	COG0759	Membrane-anchored protein YidD, putatitve component of membrane protein insertase Oxa1/YidC/SpoIIIJ	92
646481566	96	38.54	1	96	1	96	7.0e-21	92.2	COG0721	Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit	96
646481567	512	51.74	1	510	2	474	0.0e+00	497	COG0154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit or related amidase	475
646481568	496	47.34	10	493	5	481	0.0e+00	567	COG0064	Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit	483
646481569	374	30.83	1	372	2	334	4.0e-85	308	COG0136	Aspartate-semialdehyde dehydrogenase	334
646481570	285	45.86	1	266	1	262	3.0e-77	281	COG0101	tRNA U38,U39,U40 pseudouridine synthase TruA	266
646481571	388	26.58	1	384	3	379	6.0e-34	138	COG0438	Glycosyltransferase involved in cell wall bisynthesis	381
646481572	298	29.01	10	283	1	290	2.0e-32	133	COG0515	Serine/threonine protein kinase	384
646481573	337	57.19	12	323	5	317	3.0e-119	421	COG0825	Acetyl-CoA carboxylase alpha subunit	317
646481574	427	36.88	23	421	109	499	3.0e-89	322	COG2804	Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB	500
646481576	244	22.22	5	154	5	157	3.0e-10	59.1	COG1286	Uncharacterized membrane protein, required for colicin V production	182
646481578	151	61.38	1	145	1	145	3.0e-54	204	COG1490	D-Tyr-tRNAtyr deacylase	145
646481580	218	35.58	6	211	3	207	2.0e-37	149	COG0406	Broad specificity phosphatase PhoE	208
646481586	367	35.13	1	367	12	391	1.0e-86	313	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
646481588	267	24.32	21	266	19	273	7.0e-21	94.5	COG1082	Sugar phosphate isomerase/epimerase	274
646481591	456	29.3	5	313	12	313	6.0e-43	169	COG4260	Membrane protease subunit, stomatin/prohibitin family, contains C-terminal Zn-ribbon domain	345
646481594	421	37.5	14	419	4	412	6.0e-77	281	COG0304	3-oxoacyl-(acyl-carrier-protein) synthase	412
646481596	489	19.52	30	489	4	482	6.0e-33	135	COG1233	Phytoene dehydrogenase-related protein	487
646481597	481	22.06	12	467	3	481	4.0e-30	126	COG1233	Phytoene dehydrogenase-related protein	487
646481598	143	37.32	1	137	4	143	7.0e-24	103	COG0764	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratase	147
646481599	268	34.8	6	252	4	252	2.0e-46	179	COG0623	Enoyl-[acyl-carrier-protein] reductase (NADH)	259
646481600	359	22.54	10	344	8	322	1.0e-33	137	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
646481601	691	64.29	1	654	3	658	0.0e+00	1018	COG0556	Excinuclease UvrABC helicase subunit UvrB	663
646481604	241	35.03	41	191	19	175	7.0e-26	110	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481610	516	30.66	33	475	5	443	3.0e-54	206	COG3119	Arylsulfatase A or related enzyme	475
646481611	182	48.17	10	171	9	169	1.0e-43	168	COG0521	Molybdopterin biosynthesis enzyme MoaB	169
646481614	437	61.7	1	436	2	437	0.0e+00	649	COG2115	Xylose isomerase	438
646481616	297	26.39	13	294	2	282	6.0e-20	91.7	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646481617	296	30.9	13	286	1	282	6.0e-32	131	COG1767	Triphosphoribosyl-dephospho-CoA synthetase	288
646481618	182	30.33	17	137	1	114	2.0e-17	82.7	COG0720	6-pyruvoyl-tetrahydropterin synthase	127
646481619	926	35.61	7	405	1	400	5.0e-103	369	COG0004	Ammonia channel protein AmtB	409
646481620	159	33.55	1	149	1	150	9.0e-27	113	COG1406	Chemotaxis protein CheX, a CheY~P-specific phosphatase	153
646481621	331	46.89	7	326	16	337	2.0e-72	266	COG1536	Flagellar motor switch protein FliG	339
646481622	869	47.81	2	862	5	842	0.0e+00	908	COG0249	DNA mismatch repair ATPase MutS	843
646481623	372	30.2	136	372	12	253	9.0e-30	124	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
646481627	340	28.95	1	328	1	310	5.0e-39	155	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646481628	132	37.12	1	132	2	131	4.0e-23	100	COG1487	Predicted nucleic acid-binding protein, contains PIN domain	133
646481629	494	30	255	474	1	169	1.0e-32	134	COG0516	IMP dehydrogenase/GMP reductase	170
646481631	367	29.89	1	365	1	369	4.0e-52	199	COG4948	L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily	372
646481638	180	31.93	10	172	13	178	3.0e-15	75.1	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481645	451	22.45	38	374	3	308	1.0e-24	107	COG0673	Predicted dehydrogenase	342
646481646	133	46.49	20	133	22	133	2.0e-23	101	COG1259	Bifunctional DNase/RNase	151
646481647	235	29.44	1	231	1	219	4.0e-24	105	COG1214	tRNA A37 threonylcarbamoyladenosine modification protein TsaB	220
646481648	250	21.43	1	223	2	163	8.0e-07	47.7	COG0622	Predicted phosphodiesterase	172
646481649	249	19.82	1	222	2	163	1.0e-08	53.8	COG0622	Predicted phosphodiesterase	172
646481650	312	25.58	12	138	6	133	2.0e-08	53.9	COG2165	Type II secretory pathway, pseudopilin PulG	149
646481652	841	30.22	507	822	20	314	9.0e-46	179	COG0706	Membrane protein insertase Oxa1/YidC/SpoIIIJ, required for the localization of integral membrane proteins	314
646481653	466	33.05	11	466	5	454	5.0e-78	285	COG0486	tRNA U34 5-carboxymethylaminomethyl modifying GTPase MnmE/TrmE	454
646481655	592	41.69	1	402	1	447	2.0e-108	386	COG0527	Aspartokinase	447
646481656	403	41.03	1	398	4	403	1.0e-96	346	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archeal type	408
646481657	438	43.03	1	321	1	330	1.0e-81	297	COG0460	Homoserine dehydrogenase	333
646481658	364	42.56	3	335	4	338	2.0e-79	289	COG1044	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase	338
646481659	300	35.36	16	290	7	276	3.0e-53	202	COG3494	Uncharacterized conserved protein, DUF1009 family	279
646481661	294	31.45	13	288	6	247	2.0e-60	225	COG0152	Phosphoribosylaminoimidazole-succinocarboxamide synthase	247
646481662	495	21.12	207	489	69	341	2.0e-08	54.2	COG3693	Endo-1,4-beta-xylanase, GH35 family	345
646481663	312	31.5	47	292	25	274	9.0e-41	160	COG3386	Sugar lactone lactonase YvrE	307
646481665	344	48.54	1	342	3	338	3.0e-95	341	COG0547	Anthranilate phosphoribosyltransferase	338
646481666	313	40.26	1	307	1	308	3.0e-69	255	COG1957	Inosine-uridine nucleoside N-ribohydrolase	311
646481668	317	25	8	315	14	307	3.0e-43	169	COG2017	Galactose mutarotase or related enzyme	308
646481671	333	24.71	1	255	1	249	1.0e-20	94.4	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646481673	166	57.14	22	166	35	181	1.0e-40	158	COG2335	Uncaracterized surface protein containing fasciclin (FAS1) repeats	187
646481674	248	38.62	8	241	6	250	3.0e-31	128	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646481676	293	65.87	1	292	1	293	3.0e-115	408	COG0074	Succinyl-CoA synthetase, alpha subunit	293
646481677	396	59.55	1	396	1	387	0.0e+00	481	COG0045	Succinyl-CoA synthetase, beta subunit	387
646481678	269	34.57	3	266	1	251	1.0e-40	160	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646481680	489	30.3	1	260	1	261	1.0e-40	161	COG3228	Mlc titration factor MtfA, regulates ptsG expression	266
646481681	315	47.23	5	307	2	305	9.0e-91	327	COG0039	Malate/lactate dehydrogenase	313
646481683	256	24.61	51	232	19	201	2.0e-15	76.9	COG0400	Predicted esterase	207
646481686	282	32.09	23	281	71	335	1.0e-33	136	COG0642	Signal transduction histidine kinase	336
646481687	474	48.44	13	462	6	455	0.0e+00	476	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646481688	137	22.76	14	133	11	130	4.0e-10	57.6	COG1815	Flagellar basal body rod protein FlgB	133
646481689	141	40.58	4	140	6	136	2.0e-26	111	COG1558	Flagellar basal body rod protein FlgC	137
646481690	102	29.52	1	102	1	105	2.0e-14	71.1	COG1677	Flagellar hook-basal body complex protein FliE	105
646481691	553	19.16	1	549	2	542	7.0e-24	105	COG1766	Flagellar biosynthesis/type III secretory pathway M-ring protein FliF/YscJ	545
646481692	374	22.59	10	372	16	332	2.0e-24	107	COG1536	Flagellar motor switch protein FliG	339
646481693	217	23.7	10	217	24	225	1.0e-15	76.6	COG1317	Flagellar biosynthesis/type III secretory pathway protein FliH	234
646481694	455	56.15	2	431	9	439	0.0e+00	560	COG1157	Flagellar biosynthesis/type III secretory pathway ATPase	441
646481697	580	16.63	164	567	9	409	2.0e-08	54.7	COG3144	Flagellar hook-length control protein FliK	417
646481699	815	29.76	457	815	67	423	3.0e-32	134	COG1749	Flagellar hook protein FlgE	423
646481700	77	44.26	1	61	1	61	1.0e-12	64.9	COG1582	Uncharacterized protein YlzI, FlbEa/FlbD family	67
646481701	259	41.15	1	259	1	260	1.0e-59	223	COG1291	Flagellar motor component MotA	266
646481702	261	25.62	4	231	7	243	2.0e-25	109	COG1360	Flagellar motor protein MotB	244
646481704	212	38.97	73	205	1	136	4.0e-21	95.1	COG1886	Flagellar motor switch/type III secretory pathway protein FliN	136
646481705	262	23.08	117	233	16	127	1.0e-08	53.8	COG3190	Flagellar biogenesis protein FliO	137
646481706	297	51.88	56	294	25	248	1.0e-61	230	COG1338	Flagellar biosynthetic protein FliP	248
646481707	91	40.91	1	88	1	88	2.0e-13	67.5	COG1987	Flagellar biosynthesis protein FliQ	89
646481708	277	31.54	9	249	9	247	3.0e-26	112	COG1684	Flagellar biosynthesis protein FliR	258
646481709	363	37.5	1	360	2	361	4.0e-93	335	COG1377	Flagellar biosynthesis protein FlhB	363
646481711	398	26.28	45	372	17	334	2.0e-38	153	COG2141	Flavin-dependent oxidoreductase, luciferase family (includes alkanesulfonate monooxygenase SsuD and methylene tetrahydromethanopterin reductase)	336
646481712	260	22.85	20	260	17	281	8.0e-20	90.9	COG0596	Pimeloyl-ACP methyl ester carboxylesterase	282
646481713	274	45.78	19	258	2	246	8.0e-44	170	COG1028	NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family	251
646481714	262	43.4	41	252	21	219	1.0e-37	150	COG2045	Phosphosulfolactate phosphohydrolase or related enzyme	230
646481715	537	38.52	1	536	4	551	0.0e+00	515	COG0423	Glycyl-tRNA synthetase (class II)	558
646481716	272	22.55	1	267	3	272	4.0e-24	105	COG1082	Sugar phosphate isomerase/epimerase	274
646481719	465	26.35	83	465	47	426	1.0e-41	164	COG3746	Phosphate-selective porin	426
646481721	482	40.88	8	479	3	475	1.0e-120	427	COG0469	Pyruvate kinase	477
646481726	514	53.03	5	415	1	409	6.0e-124	438	COG0119	Isopropylmalate/homocitrate/citramalate synthases	409
646481732	359	39.65	5	342	1	341	2.0e-78	286	COG2008	Threonine aldolase	342
646481733	391	44.1	5	391	2	387	2.0e-107	383	COG0156	7-keto-8-aminopelargonate synthetase or related enzyme	388
646481734	380	35.41	15	356	1	349	2.0e-69	256	COG1063	Threonine dehydrogenase or related Zn-dependent dehydrogenase	350
646481735	202	42.86	21	76	5	60	3.0e-09	55.2	COG1476	DNA-binding transcriptional regulator, XRE-family HTH domain	68
646481736	454	53.23	55	454	24	422	5.0e-128	451	COG0141	Histidinol dehydrogenase	425
646481737	350	38.24	3	349	2	353	3.0e-79	289	COG0079	Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase	356
646481738	198	60.2	1	196	2	195	1.0e-78	285	COG0131	Imidazoleglycerol phosphate dehydratase HisB	195
646481741	511	29.54	27	476	3	443	6.0e-53	202	COG3119	Arylsulfatase A or related enzyme	475
646481743	434	26.59	13	434	2	346	2.0e-48	186	COG0205	6-phosphofructokinase	347
646481745	370	32.19	3	366	6	376	1.0e-47	184	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
646481746	233	35.9	1	192	10	200	5.0e-27	114	COG3222	Uncharacterized conserved protein, glycosyltransferase A (GT-A) superfamily, DUF2064 family	211
646481747	659	32.62	76	340	1	279	2.0e-41	164	COG0515	Serine/threonine protein kinase	384
646481752	291	40.67	19	286	2	265	3.0e-66	245	COG1606	ATP-utilizing enzyme, PP-loop superfamily	269
646481753	426	23.43	118	291	4	173	1.0e-16	81.6	COG3330	Uncharacterized conserved protein	215
646481758	303	30.97	145	299	4	158	5.0e-14	72.2	COG0711	FoF1-type ATP synthase, membrane subunit b or b'	161
646481759	208	33.14	15	186	4	174	1.0e-30	126	COG0712	FoF1-type ATP synthase, delta subunit	178
646481760	504	66.73	1	502	1	500	0.0e+00	768	COG0056	FoF1-type ATP synthase, alpha subunit	504
646481761	124	41.04	17	124	12	143	3.0e-20	90.8	COG3296	Uncharacterized conserved protein, Tic20 family	143
646481762	296	39.66	5	294	1	286	8.0e-68	250	COG0224	FoF1-type ATP synthase, gamma subunit	287
646481763	482	67.72	10	480	4	467	0.0e+00	744	COG0055	FoF1-type ATP synthase, beta subunit	468
646481764	132	35.88	3	129	2	132	2.0e-20	91.1	COG0355	FoF1-type ATP synthase, epsilon subunit	135
646481770	319	46.01	132	294	10	162	2.0e-39	156	COG1045	Serine acetyltransferase	194
646481771	236	50	1	236	2	239	1.0e-76	279	COG0106	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase	241
646481772	210	53.2	1	203	1	202	8.0e-75	273	COG0118	Imidazoleglycerol phosphate synthase glutamine amidotransferase subunit HisH	204
646481780	283	41.23	164	276	5	118	2.0e-20	93.4	COG2207	AraC-type DNA-binding domain and AraC-containing proteins	127
646481791	554	27.99	146	553	83	481	8.0e-41	162	COG0286	Type I restriction-modification system, DNA methylase subunit	489
646481792	932	29.55	3	919	12	875	0.0e+00	524	COG4096	Type I site-specific restriction endonuclease, part of a restriction-modification system	875
646481797	308	26.45	1	307	14	310	6.0e-28	118	COG2378	Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains	311
646481798	279	26.48	44	273	90	339	5.0e-18	85.3	COG2957	Agmatine/peptidylarginine deiminase	346
646481799	298	24.49	35	275	4	239	6.0e-33	134	COG0338	Site-specific DNA-adenine methylase	274
646481805	377	39.71	103	366	17	283	7.0e-68	251	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	283
646481806	406	29.85	10	397	33	408	7.0e-48	184	COG2124	Cytochrome P450	411
646481808	352	21.32	104	347	2	237	1.0e-33	137	COG2356	Endonuclease I	237
646481809	1466	24.28	449	712	13	251	4.0e-27	118	COG1864	DNA/RNA endonuclease G, NUC1	281
646481812	743	21.74	495	733	2	232	8.0e-36	145	COG2356	Endonuclease I	237
646481826	327	33.33	1	111	4	117	3.0e-08	53.1	COG2165	Type II secretory pathway, pseudopilin PulG	149
646481828	364	39.35	4	357	10	380	4.0e-78	285	COG0006	Xaa-Pro aminopeptidase	384
646481829	169	34.25	20	165	1	138	5.0e-21	94.4	COG0511	Biotin carboxyl carrier protein	140
646481830	451	61.12	1	445	1	445	0.0e+00	589	COG0439	Biotin carboxylase	449
646481831	437	23.81	52	374	4	310	6.0e-30	125	COG0673	Predicted dehydrogenase	342
646481832	422	42.55	4	422	3	420	2.0e-111	396	COG0044	Dihydroorotase or related cyclic amidohydrolase	430
646481833	326	46.2	15	321	5	316	2.0e-94	339	COG0540	Aspartate carbamoyltransferase, catalytic chain	316
646481835	338	24.55	28	233	2	211	1.0e-15	77.7	COG2755	Lysophospholipase L1 or related esterase	216
646481836	115	53.04	1	115	1	112	5.0e-32	129	COG0347	Nitrogen regulatory protein PII	112
646481837	521	37.25	87	486	5	403	3.0e-91	329	COG0004	Ammonia channel protein AmtB	409
646481839	343	44.64	11	339	5	340	2.0e-90	326	COG0552	Signal recognition particle GTPase	340
646481840	136	34.75	1	135	7	147	1.0e-27	115	COG0781	Transcription termination factor NusB	151
646481841	978	18.29	347	640	4	313	1.0e-11	66	COG0515	Serine/threonine protein kinase	384
646481842	352	54.77	25	347	2	326	2.0e-117	416	COG2255	Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit	332
646481844	473	23.66	20	402	17	382	3.0e-22	100	COG1012	Acyl-CoA reductase or other NAD-dependent aldehyde dehydrogenase	472
646481848	383	40.21	6	383	4	377	4.0e-92	332	COG1454	Alcohol dehydrogenase, class IV	377
646481849	399	25.24	90	380	15	289	9.0e-24	104	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646481850	436	33.41	16	427	10	411	1.0e-68	254	COG0635	Coproporphyrinogen III oxidase or related Fe-S oxidoreductase	416
646481851	152	34.38	15	137	4	130	6.0e-23	100	COG0509	Glycine cleavage system H protein (lipoate-binding)	131
646481852	397	33.87	250	309	1	61	5.0e-09	56	COG1146	NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit	68
646481853	494	26.52	41	403	3	456	1.0e-37	151	COG3119	Arylsulfatase A or related enzyme	475
646481854	282	20.73	90	279	53	244	1.0e-19	90.5	COG1360	Flagellar motor protein MotB	244
646481857	357	25.38	2	320	4	313	3.0e-30	126	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646481858	321	27.64	5	316	1	314	3.0e-34	138	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646481859	462	31.41	37	434	6	369	1.0e-86	314	COG0399	dTDP-4-amino-4,6-dideoxygalactose transaminase	374
646481860	349	22.48	10	303	1	291	5.0e-16	79	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646481862	145	29.55	7	134	7	138	6.0e-08	50.1	COG4961	Flp pilus assembly protein TadG	185
646481865	257	38.49	2	250	8	257	6.0e-43	167	COG0725	ABC-type molybdate transport system, periplasmic component	258
646481866	233	52.51	4	222	1	218	5.0e-59	220	COG4149	ABC-type molybdate transport system, permease component	225
646481868	344	44.14	12	343	1	328	2.0e-93	336	COG1995	4-hydroxy-L-threonine phosphate dehydrogenase PdxA	332
646481869	445	18.21	57	389	16	321	5.0e-06	46	COG1520	Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat	370
646481876	1278	28.29	345	733	2	381	8.0e-42	166	COG0515	Serine/threonine protein kinase	384
646481877	675	38.58	254	506	98	336	3.0e-42	166	COG0642	Signal transduction histidine kinase	336
646481878	377	33.62	151	375	17	247	2.0e-32	133	COG2200	EAL domain, c-di-GMP-specific phosphodiesterase class I (or its enzymatically inactive variant)	256
646481879	336	54.68	6	334	3	325	6.0e-112	397	COG0158	Fructose-1,6-bisphosphatase	326
646481887	315	35.8	5	253	2	258	3.0e-57	215	COG1131	ABC-type multidrug transport system, ATPase component	293
646481889	263	41.23	150	263	1	111	7.0e-26	111	COG2151	Metal-sulfur cluster biosynthetic enzyme	111
646481890	443	30.95	22	438	3	410	7.0e-83	301	COG0719	Fe-S cluster assembly scaffold protein SufB	412
646481891	471	47.6	40	469	1	412	8.0e-126	444	COG0719	Fe-S cluster assembly scaffold protein SufB	412
646481892	273	55.08	4	258	3	251	5.0e-89	320	COG0396	Fe-S cluster assembly ATPase SufC	251
646481893	227	58.64	26	187	13	172	1.0e-64	239	COG0377	NADH:ubiquinone oxidoreductase 20 kD subunit (chhain B) or related Fe-S oxidoreductase	194
646481894	240	29.05	19	227	16	209	4.0e-22	98.5	COG2345	Predicted transcriptional regulator, ArsR family	218
646481895	429	27.94	39	414	1	361	2.0e-35	144	COG0683	ABC-type branched-chain amino acid transport system, periplasmic component	366
646481896	326	39.94	14	325	2	297	4.0e-49	188	COG0559	Branched-chain amino acid ABC-type transport system, permease component	297
646481897	381	43.56	38	363	13	312	4.0e-51	195	COG4177	ABC-type branched-chain amino acid transport system, permease component	314
646481898	440	59.12	257	436	73	250	7.0e-63	235	COG0411	ABC-type branched-chain amino acid transport system, ATPase component	250
646481899	237	59.83	4	236	3	236	3.0e-91	327	COG0410	ABC-type branched-chain amino acid transport system, ATPase component	237
646481900	345	38.97	3	333	1	322	2.0e-73	269	COG0042	tRNA-dihydrouridine synthase	323
646481901	201	36.65	13	199	5	190	2.0e-33	135	COG0212	5-formyltetrahydrofolate cyclo-ligase	191
646481902	368	29.6	12	368	11	380	1.0e-45	177	COG0006	Xaa-Pro aminopeptidase	384
646481903	669	40.92	3	649	1	638	0.0e+00	519	COG0210	Superfamily I DNA or RNA helicase	655
646481906	659	24.88	75	278	26	185	2.0e-09	58.3	COG0693	Putative intracellular protease/amidase	188
646481907	727	34.29	90	385	2	298	6.0e-48	186	COG0515	Serine/threonine protein kinase	384
646481908	200	27.08	5	196	1	182	3.0e-15	75.1	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646481909	229	35.85	7	216	2	211	2.0e-34	138	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646481911	154	52.9	16	153	15	152	1.0e-41	162	COG0054	6,7-dimethyl-8-ribityllumazine synthase (Riboflavin synthase beta chain)	152
646481916	243	38.64	5	221	1	218	2.0e-46	178	COG0235	Ribulose-5-phosphate 4-epimerase/Fuculose-1-phosphate aldolase	219
646481918	266	23.75	17	266	4	244	3.0e-13	69.4	COG1209	dTDP-glucose pyrophosphorylase	286
646481919	508	28.96	286	462	1	179	9.0e-14	72.2	COG0406	Broad specificity phosphatase PhoE	208
646481920	363	25.99	176	347	31	204	6.0e-15	75.6	COG0036	Pentose-5-phosphate-3-epimerase	220
646481922	245	17.8	15	239	5	239	3.0e-13	69	COG0463	Glycosyltransferase involved in cell wall bisynthesis	291
646481931	136	55.64	1	133	1	133	5.0e-41	160	COG3607	Predicted lactoylglutathione lyase	133
646481932	155	31.85	3	154	1	155	1.0e-22	99.3	COG3708	Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain	157
646481933	140	40.8	1	123	1	123	5.0e-34	136	COG3795	Uncharacterized conserved protein	123
646481935	415	57.21	10	414	4	412	3.0e-121	428	COG4941	Predicted RNA polymerase sigma factor, contains C-terminal TPR domain	415
646481936	243	24.08	53	240	4	185	1.0e-07	50.4	COG2020	Protein-S-isoprenylcysteine O-methyltransferase Ste14	187
646481938	338	42.4	1	335	5	342	1.0e-67	250	COG1294	Cytochrome bd-type quinol oxidase, subunit 2	346
646481939	490	45.4	1	465	2	454	2.0e-126	446	COG1271	Cytochrome bd-type quinol oxidase, subunit 1	457
646481945	323	24.52	46	290	2	251	2.0e-19	90.3	COG1082	Sugar phosphate isomerase/epimerase	274
646481946	190	30.81	1	186	2	184	1.0e-22	99.5	COG0693	Putative intracellular protease/amidase	188
646481949	216	31.92	3	215	2	213	7.0e-40	157	COG0637	Beta-phosphoglucomutase or related phosphatase, HAD superfamily	221
646481951	478	25.05	25	468	1	475	2.0e-40	161	COG3119	Arylsulfatase A or related enzyme	475
646481954	422	34.1	30	411	7	391	1.0e-88	320	COG0436	Aspartate/methionine/tyrosine aminotransferase	393
646481955	383	59.03	5	373	4	362	0.0e+00	538	COG0505	Carbamoylphosphate synthase small subunit	368
646481958	411	25.9	81	381	2	310	2.0e-31	130	COG1262	Formylglycine-generating enzyme, required for sulfatase activity, contains SUMF1/FGE domain	314
646481963	479	44.37	9	469	2	458	0.0e+00	490	COG1139	L-lactate utilization protein LutB, contains a ferredoxin-type domain	459
646481964	243	31	17	243	3	217	6.0e-27	114	COG1556	L-lactate utilization protein LutC, contains LUD domain	218
646481965	242	24.81	7	240	26	287	5.0e-17	81.4	COG0682	Prolipoprotein diacylglyceryltransferase	287
646481966	518	27.66	3	490	2	447	1.0e-69	257	COG1964	Uncharacterized Fe-S cluster-containing enzyme, radical SAM superfamily	514
646481970	603	42.4	1	499	1	528	0.0e+00	493	COG0488	ATPase components of ABC transporters with duplicated ATPase domains	530
646481971	603	42.52	1	290	2	294	3.0e-87	316	COG1054	Predicted sulfurtransferase	308
646481972	679	26.77	371	672	106	393	9.0e-23	102	COG2133	Glucose/arabinose dehydrogenase, beta-propeller fold	399
646481974	189	50.88	17	186	15	185	2.0e-42	165	COG4341	Predicted HD phosphohydrolase	186
646481976	474	18.45	91	426	53	341	2.0e-06	47.4	COG0845	Multidrug efflux pump subunit AcrA (membrane-fusion protein)	372
646481977	1179	35.49	240	1144	143	1018	0.0e+00	661	COG3696	Cu/Ag efflux pump CusA	1027
646481980	116	32.39	34	104	1	70	1.0e-08	51.9	COG2608	Copper chaperone CopZ	71
646481982	137	35.04	8	135	2	138	6.0e-28	116	COG0394	Protein-tyrosine-phosphatase	139
646481983	239	34.48	5	218	8	238	4.0e-34	138	COG0580	Glycerol uptake facilitator and related aquaporins (Major Intrinsic Protein Family)	241
646481984	544	27.05	20	301	36	312	6.0e-24	105	COG0657	Acetyl esterase/lipase	312
646481987	702	53.61	1	700	10	689	0.0e+00	810	COG1523	Pullulanase/glycogen debranching enzyme	697
646481989	266	36.43	135	263	15	141	7.0e-18	84.3	COG4335	3-methyladenine DNA glycosylase AlkC	167
646481990	911	44.18	3	635	1	598	0.0e+00	525	COG1042	Acyl-CoA synthetase (NDP forming)	598
646481993	414	22.46	6	391	14	428	9.0e-22	98.5	COG1215	Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase	439
646481995	505	35.37	258	498	1	241	7.0e-37	149	COG1587	Uroporphyrinogen-III synthase	248
646481995	505	49.59	8	251	4	243	5.0e-72	265	COG0007	Uroporphyrinogen-III methylase (siroheme synthase)	244
646481997	93	47.73	1	88	1	88	2.0e-08	50.7	COG0268	Ribosomal protein S20	88
646481998	286	29.96	17	286	8	252	3.0e-37	149	COG0543	NAD(P)H-flavin reductase	252
646481999	811	44.94	33	269	2	247	2.0e-62	234	COG1187	16S rRNA U516 pseudouridylate synthase RsuA and related 23S rRNA U2605, pseudouridylate synthases	248
646482002	323	33.02	5	317	2	308	1.0e-59	223	COG1482	Mannose-6-phosphate isomerase, class I	312
646482003	476	34.87	278	472	55	249	6.0e-44	172	COG0805	Sec-independent protein secretion pathway component TatC	255
646482004	769	42.49	26	768	3	730	0.0e+00	689	COG1198	Primosomal protein N' (replication factor Y) - superfamily II helicase	730
646482005	394	25.25	1	388	2	383	1.0e-31	131	COG0665	Glycine/D-amino acid oxidase (deaminating)	387
646482006	423	35	1	400	1	338	3.0e-81	296	COG3839	ABC-type sugar transport system, ATPase component	338
646482007	404	49.47	126	312	1	182	5.0e-40	158	COG0195	Transcription antitermination factor NusA, contains S1 and KH domains	190
646482008	1041	50.1	529	1041	1	507	0.0e+00	559	COG0532	Translation initiation factor IF-2, a GTPase	509
646482009	165	31.25	1	111	2	113	1.0e-18	86.4	COG0858	Ribosome-binding factor A	118
646482014	379	30.57	9	343	3	312	2.0e-35	143	COG0472	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase	319
646482016	503	29.66	1	503	3	499	5.0e-100	358	COG0442	Prolyl-tRNA synthetase	500
646482020	249	29.7	1	249	1	248	1.0e-26	113	COG0095	Lipoate-protein ligase A	248
646482021	488	50.93	9	486	8	486	0.0e+00	609	COG1003	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain	496
646482022	464	42.25	8	445	16	446	0.0e+00	461	COG0403	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain	450
646482023	131	42.64	3	130	6	131	1.0e-29	121	COG0509	Glycine cleavage system H protein (lipoate-binding)	131
646482024	373	45.65	1	372	1	375	2.0e-105	376	COG0404	Glycine cleavage system T protein (aminomethyltransferase)	379
646482025	328	36.45	11	327	6	301	2.0e-60	226	COG0803	ABC-type Zn uptake system ZnuABC, Zn-binding component ZnuA	303
646482026	258	49	6	254	2	252	6.0e-83	300	COG1121	ABC-type Mn2+/Zn2+ transport system, ATPase component	254
646482027	437	36.46	1	277	10	274	7.0e-43	168	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	274
646482028	481	30.91	52	326	15	272	2.0e-48	187	COG1108	ABC-type Mn2+/Zn2+ transport system, permease component	274
646482029	369	27.79	30	362	1	329	3.0e-29	123	COG1609	DNA-binding transcriptional regulator, LacI/PurR family	333
646482033	955	42.24	192	834	62	705	0.0e+00	533	COG0557	Exoribonuclease R	706
646482034	382	20.27	1	318	1	356	2.0e-10	60.4	COG1819	UDP:flavonoid glycosyltransferase YjiC, YdhE family	406
646482035	311	32.92	36	271	1	236	7.0e-40	158	COG2908	UDP-2,3-diacylglucosamine pyrophosphatase LpxH	237
646482038	324	29.01	14	305	1	279	1.0e-33	137	COG3481	3'-5' exoribonuclease YhaM, can participate in 23S rRNA maturation,  HD superfamily	287
646482039	186	52.8	1	161	3	162	1.0e-45	176	COG0440	Acetolactate synthase, small subunit	163
646482040	334	63.96	1	333	1	333	0.0e+00	509	COG0059	Ketol-acid reductoisomerase	338
646482042	292	25.74	15	277	5	241	5.0e-22	98.4	COG0731	Wyosine [tRNA(Phe)-imidazoG37] synthetase, radical SAM superfamily	296
646482044	112	42.59	47	100	1	54	1.0e-12	65.3	COG3411	(2Fe-2S) ferredoxin	64
646482047	480	33.19	5	475	1	442	3.0e-75	276	COG1232	Protoporphyrinogen oxidase	444
646482048	204	36.06	1	199	1	208	1.0e-40	159	COG2808	Predicted FMN-binding regulatory protein PaiB	209
646482050	322	36.65	3	309	1	310	9.0e-55	207	COG0451	Nucleoside-diphosphate-sugar epimerase	314
646482051	409	27.83	3	389	4	379	5.0e-34	139	COG0402	Cytosine/adenosine deaminase or related metal-dependent hydrolase	421
646482052	283	40.14	2	282	1	289	2.0e-67	249	COG0040	ATP phosphoribosyltransferase	290
646482053	119	43.48	15	106	1	89	9.0e-22	95.6	COG0140	Phosphoribosyl-ATP pyrophosphohydrolase	92
646482056	348	48.78	29	315	8	280	2.0e-88	319	COG0324	tRNA A37 N6-isopentenylltransferase MiaA	308
646482057	591	58.8	2	586	1	583	0.0e+00	876	COG0173	Aspartyl-tRNA synthetase	585
646482061	397	22.63	23	395	13	408	1.0e-33	138	COG2195	Di- or tripeptidase	414
646482062	391	51.51	43	371	9	340	1.0e-110	393	COG0820	Adenine C2-methylase RlmN of 23S rRNA A2503 and tRNA A37	349
646482063	471	35.12	39	471	40	458	9.0e-75	274	COG5361	Uncharacterized conserved protein	458
646482064	347	62.9	2	345	1	332	1.0e-124	439	COG0057	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase	335
646482065	423	24.26	42	327	13	313	2.0e-26	113	COG0535	Radical SAM superfamily enzyme, MoaA/NifB/PqqE/SkfB family	347
646482068	603	56.81	3	603	2	603	0.0e+00	911	COG0481	Translation elongation factor EF-4, membrane-bound GTPase	603
646482069	342	33.94	15	340	8	312	4.0e-48	185	COG1940	Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain	314
646482070	238	31.53	3	217	2	222	5.0e-31	127	COG2120	N-acetylglucosaminyl deacetylase, LmbE family	237
646482073	322	24.03	19	142	6	134	5.0e-08	52.4	COG2165	Type II secretory pathway, pseudopilin PulG	149
646482076	323	46.43	1	307	5	300	6.0e-90	324	COG4974	Site-specific recombinase XerD	300
646482079	220	26.13	61	171	1	110	3.0e-08	52.2	COG1846	DNA-binding transcriptional regulator, MarR family	126
646482081	630	22.56	103	417	63	343	6.0e-15	76.1	COG1566	Multidrug resistance efflux pump	352
646482082	246	49.55	6	227	3	226	8.0e-78	283	COG1136	ABC-type lipoprotein export system, ATPase component	226
646482083	471	27.59	19	471	2	419	3.0e-35	143	COG0577	ABC-type antimicrobial peptide transport system, permease component	419
646482087	333	29.46	1	111	4	114	4.0e-09	55.8	COG2165	Type II secretory pathway, pseudopilin PulG	149
646482088	265	33.7	81	255	1	181	3.0e-26	112	COG1595	DNA-directed RNA polymerase specialized sigma subunit, sigma24 family	182
646482093	262	26.94	22	212	13	198	3.0e-08	52.3	COG3063	Tfp pilus assembly protein PilF	250
646482094	368	50.55	8	368	4	365	1.0e-120	426	COG1932	Phosphoserine aminotransferase	365
646482095	542	45.99	1	323	3	323	2.0e-85	310	COG0111	Phosphoglycerate dehydrogenase or related dehydrogenase	324
646482097	457	47.73	1	457	2	462	0.0e+00	492	COG2204	DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains	464
646482098	210	41.63	3	210	1	209	2.0e-46	178	COG2197	DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains	211
646482099	124	33.66	1	99	10	110	2.0e-11	61.4	COG0640	DNA-binding transcriptional regulator, ArsR family	110
646482100	166	27.98	3	164	1	149	3.0e-15	74.7	COG3832	Uncharacterized conserved protein YndB, AHSA1/START domain	149
646482101	290	26.9	21	209	16	208	2.0e-18	86.7	COG0705	Membrane associated serine protease, rhomboid family	228
646482102	257	26.89	1	210	1	233	8.0e-16	77.7	COG3332	Uncharacterized conserved protein, contains NRDE domain	270
646482103	373	28.77	8	370	2	342	4.0e-55	208	COG0673	Predicted dehydrogenase	342
646482104	338	47.99	18	338	4	322	2.0e-96	345	COG0332	3-oxoacyl-[acyl-carrier-protein] synthase III	323
646482105	600	40.17	7	600	1	596	0.0e+00	478	COG1164	Oligoendopeptidase F	598
646482108	345	26.6	62	339	16	282	1.0e-55	210	COG2230	Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases	283
646482109	266	37.5	11	264	16	270	6.0e-50	190	COG3752	Steroid 5-alpha reductase family enzyme	272
646482110	357	24.41	1	338	2	326	2.0e-37	149	COG0859	ADP-heptose:LPS heptosyltransferase	334
646482111	334	28.62	23	319	5	279	1.0e-36	147	COG3481	3'-5' exoribonuclease YhaM, can participate in 23S rRNA maturation,  HD superfamily	287
646482112	437	27.32	232	412	2	180	5.0e-21	96	COG2199	GGDEF domain, diguanylate cyclase (c-di-GMP synthetase) or its enzymatically inactive variants	181
646482113	292	40	8	292	2	278	7.0e-59	221	COG2890	Methylase of polypeptide chain release factors	280
646482114	358	51.54	1	354	5	361	4.0e-123	434	COG0216	Protein chain release factor A	363
646482115	87	53.52	1	67	1	71	2.0e-18	83.8	COG0254	Ribosomal protein L31	75
646482116	329	20.95	16	325	5	307	1.0e-18	87.5	COG0385	Predicted Na+-dependent transporter	319
646482117	379	46.01	1	373	8	369	3.0e-106	378	COG0082	Chorismate synthase	369
646482119	707	26.12	69	667	18	620	2.0e-73	270	COG1506	Dipeptidyl aminopeptidase/acylaminoacyl peptidase	620
646562218	388	23.85	126	346	47	273	1.0e-07	51.4	COG4974	Site-specific recombinase XerD	300
646562219	264	29.17	8	97	1	96	2.0e-08	53.6	COG3293	Transposase	124
646562222	265	30.21	8	99	1	96	2.0e-10	60.1	COG3293	Transposase	124
646562226	48	57.78	4	48	3	47	5.0e-07	46.3	COG4338	Uncharacterized protein	54
646562230	309	32.79	7	309	1	295	7.0e-57	214	COG1090	NAD dependent epimerase/dehydratase family enzyme	297
646562231	405	23.57	111	368	31	293	1.0e-06	48.3	COG4974	Site-specific recombinase XerD	300
646562234	424	23.18	45	392	3	338	8.0e-26	111	COG0673	Predicted dehydrogenase	342
646562249	346	27.67	18	324	20	283	6.0e-23	101	COG4974	Site-specific recombinase XerD	300
646562260	679	39.12	1	679	1	638	0.0e+00	549	COG0323	DNA mismatch repair ATPase MutL	638
646562262	495	30.83	139	402	40	299	2.0e-33	137	COG0668	Small-conductance mechanosensitive channel	316
646562263	266	30.21	8	99	1	96	2.0e-10	60.1	COG3293	Transposase	124
646562265	165	18.49	10	155	12	135	1.0e-05	42.9	COG0848	Biopolymer transport protein ExbD	137
646562271	484	25.38	213	460	59	296	2.0e-13	70.6	COG4974	Site-specific recombinase XerD	300
