LOCUS       c00073_3300000..       17564 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300000232.a:TB_PC08_64DRAFT_1000415.
ACCESSION   c00073_3300000..
VERSION     c00073_3300000..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 04:14:01
            Original ID  :: 3300000232.a:TB_PC08_64DRAFT_1000415
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 5371
            Orig. end    :: 22935
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17564
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[15371:20403]"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03882) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15032
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((YcaO or TIGR03882) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /neighbourhood="10000"
                     /product="thiopeptide"
                     /protocluster_number="1"
     cand_cluster    1..17564
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((YcaO or TIGR03882) and ((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or PF07366 or PF06968 or PF04055) or
                     thiostrepton)"
                     /kind="single"
                     /product="thiopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..17564
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="thiopeptide"
                     /region_number="1"
                     /rules="((YcaO or TIGR03882) and ((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or PF07366 or PF06968 or PF04055) or thiostrepton)"
                     /tool="antismash"
     CDS             complement(4451..5611)
                     /gene_functions="transport (smcogs) SMCOG1282:extracellular
                     ligand-binding receptor (Score: 55.9; E-value: 5.3e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg73_6"
                     /transl_table=11
                     /translation="MNQTIKIGFLFPYSSVAPHMSQDIIDGFFTSIPEIYRKNFQFYPE
                     YIDKGSHELVKVAVNKLIMFHNVDIISGIVSYKLMPEINSILEKQKKLAFFFDLGEYLP
                     PLTPISENIFFNSLQFWQVEYALGLWAQKQFSGKGAILMSIYEAGYQMHSAFWQGALSA
                     GAEEIDMHILPFNPQLPNIEDLLPPFFEKIKQSKVDYLHALFCGSEAFEFYKCYCQSDI
                     YNKIPLVVTPYMASDETLDNVPKSNITLYSASTWNYNSMVEKNQRFKSAYHLSTGKKAS
                     EFAVMGYEMGQLFLPMLPILQRKDLKEIIKYIKDANVNGPRGFRNFHHDSTLAPPIIDI
                     EKITTHNDKLSRIVLEQGIALKHNDSVFYDIHTQCVSGWKNPYLCV"
     CDS             complement(5671..6231)
                     /locus_tag="ctg73_7"
                     /transl_table=11
                     /translation="MAQILAFAFGWAPMGFQICDGSILQISQNSALYSLLGTYFGGNGT
                     QTFGIPDLKGRTILGQGNGTGLTPRPFASMGGVEQVALSQNEMPIHSHTAVFTGNSVTI
                     KANITQGSSGSPTTRANSLGALSAGSLYNGTAPDVALNVGGGAVTGTVAVANAGQSIGH
                     NNMQPFTVLNYCIATQGIYPTRP"
     CDS             complement(6269..7252)
                     /locus_tag="ctg73_8"
                     /transl_table=11
                     /translation="MVGSTNINLARVATDTLISCGNDFQKMKQSVDSLYQLFKSITGID
                     FTNWSDGDIHLPSGKAISPEGAAHCLLEMKRTAIFLRGIKQAIDSKMGDGKEQVKILYA
                     GCGPYATLITPLLHYYSADRISVTLLDVNSVSLSSAEKLIKELCLGGYIDQFVLADAAT
                     YKVDRSYDIVISETMQAGLKNEPQVAITQNLAPQCKSDTIFIPEQIKIDAYLKRRGIWN
                     GDQLLEEGGETNHLCELFTVSKANLDSNSYRKVVTLPHTSDKPYDLLLYTTIKVFGNEV
                     LELNDCSLNMPLRYFELRDNCPKSIEFWYNQSNKPKIESKILDYIT"
     CDS             8203..8334
                     /locus_tag="ctg73_9"
                     /transl_table=11
                     /translation="MVSDLLVELFVRCKPTEDIVLGRIGQFPCNFYDSPGVNTDNCF"
     CDS             10001..11341
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_10"
                     /sec_met_domain="PF04055 (E-value: 8.1e-15, bitscore: 45.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.4e-11, bitscore: 34.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKYKLSKYNVFVDKDPKGFIYNLLSNELFSFKHELFNYLKNSEG
                     TVDESTLKPELINSLYSSNIILDETENEINMLHYDYHKDKYDDSFISLVIYATLKCNFN
                     CHYCYEKHKNISMSDEKFDILKQFLIKESATRKFIATRWSGGEPLLVWKKIYNTSLEII
                     DACKKNNCNYISSIVCNGYLLTETILDEMLSVHINSIQITLDGNPENHNRVRFLKDGTG
                     TFDRILQSIEMASKRMKVILRLNIDKNNIHQFNELFEILSKSKINKSNVRIFCKPVVCT
                     IARIPENPLFSHEEFYSVEKKLIESATKNDLIYSFHWGVKSRKTRCVYHTLTGFLADPE
                     LNLFRCPIYIGGDLEHKVGHIDNQGLHITNREEYLKTLSYSPFDLQECKECKVLPICNG
                     KCPVLWEISGRKKEEGCIPDKYSFEKKLKYAIENERQLEALRNSTIN"
     CDS             11365..13224
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 197.3; E-value: 6.7e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_11"
                     /sec_met_domain="PF04055 (E-value: 1.7e-20, bitscore: 63.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVALLFCPVKGNTNYPPLSVSLLSSYLKKNGVNSSVIDLNKALYL
                     ENEELAANYSYYFAFPSIFSGYTDNENEIKNVDTIYNFSLLLSILYGSDKLPYTYNKEE
                     KEFVQQLEQEIDSKANLITNSNYKYIGFSTYVSNIAYSCILAKKLKEKNPNISLFFGGS
                     STSFSPIREFLLEMKLADYVIVGEGEEALVKLINDLESGSQPNYNTIFSENIAPENPKN
                     NETIVPIISSLNSLPFPDFSDFILSNYSPKNKDYTILPISSSRGCINQCVYCSEAQYWQ
                     RFRQRSVTNVVNEIKHGVIKYNAKCFFFHDSLINGNIKWLEDFCDQLIEEELNIHWFSF
                     ASVQNLNFEILEKMQKAGCISLTYGIEHISEKVLKNMNKRSSLGKAKEILEASVEIGIM
                     PTANIIYGLLGEDDEDFANLLYFISLPQFREKVYFTYRAFEIRVGSIISNKIIEEMDDI
                     KIRKSNFSKFNEQQKKIFSKIDIYWLPNSEYVSKLMLKLNVINKFIREQEGTLNTKQSI
                     IRNYDTTPILKSIVTLKQYPLVVCNESEIDGVLYGLSHVQKEIVSGASKKQNLLEISDA
                     MYAKITTLNPSSIYNSDEVKKTINEAVIEKAILLTQKGIIKWK"
     CDS             13215..15032
                     /gene_functions="biosynthetic (rule-based-clusters)
                     thiopeptide: YcaO"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg73_12"
                     /sec_met_domain="YcaO (E-value: 5.5e-42, bitscore: 134.4,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVKRFKRYKAKSPNETINEIRNTLHKLGILMKEEHFKDKDSMFY
                     SCSIFICNEGLDEYNLGCNGKGMTAEYALASAYGEFMERLQNNLIFMHQDFAKSKFLSQ
                     LKENQPFFYNKIHDENLLLNYNFAPDESYTKSSTENKEIINQFITNPDTYYNGLLEDEK
                     LTLLPFFNVFEEKIEKLPIELIIHNCTSNGMSAGNTPKEALIQGLSEIFERYAIRLIYK
                     ENLSLPSIPKEYFKGTKIYENIIHLEKENGWEIDIKDCSCGKKIPAIGVLIHDKINIKH
                     QFHIGVDPSPITALERSLTEIYQGRTDVLFHEIDLAYQSRLMTDMDLKETEMFKTYVDS
                     RGIYPISLFSKNYKYSFEGFNSDLGLSDDSDLNYMIETVKQLGFKMYIRNSSFLNFPAF
                     HVYIPGMSEIKNVFSSTHFNRQYKKTRNYFLTAHNLPKASNTEIETLLEYIKWDEKNVN
                     VMKFFNNKDGLLTKDTDLVLAVLNIKIGNNREAIKHIDKYIESIKTIEGITFFKCIKDI
                     LFVKDNNNKEFIELMNKIYSPEVIKNASSFIEEKNILDYFNFSSCFECDKCKIYSSCSF
                     FNVLKIAKEVEVAFKNNILDQSMIPQYIN"
     CDS             15044..17368
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 71.4; E-value: 1.3e-21)"
                     /gene_kind="transport"
                     /locus_tag="ctg73_13"
                     /transl_table=11
                     /translation="MKKIFLTVLLGILTHIVNAQEFVIKGRLINQEKSPIGNASIVLTK
                     NEVETPVVKAGTSGNDGGFEFSKIRSGEYILKIYYLGYAKKEINVQLKDSNINMEDIVL
                     NEQTQDLSEVVVTANSVSSFAEKNTYRPTTIDRQSSSNALDALKSLPKLLVGMSDQILT
                     TKGEQVKVLLNGINATESDLLSIPPDNIARIEYYQTPPARYALLGIGAVVNVITKDNVI
                     GGQVATSLQNALTTGFGNDLVNFKYNFGSSQIGIKYNLSYRDYSKRTADELLNYNFNGI
                     EYNKNKIGYNSPYNYQNHVFEVNFTNQKPDNYVFNTIISLNKFDQDKETGQNVEQMSPT
                     YMLNSALNKENNKYLKPSIDLYYTKKIDKVQELSMNVVGTYYDATFINKYLEKTATSDT
                     NFYSATNINSDKYSLISDAIYSYSLEHEKISVGLRNMYGYSKQNVLTTGTENLTSNQND
                     FYGFAELTGNRSKLSYSLSAGLNFSTFDSYELDKNYSYLYFRPIINFRYELNDKSDIFL
                     SYQINTRNPSLSELSKNPVMQDYYFAYCGNPNLEPFTTHSTMLSYGYMADNFNFSIDFS
                     FDYSNNPILPYFITQPSYILQTYSNLEDAKKYSISLFTQWFPFKSKWLRLRLSNEMFRN
                     ENRGVDFSWSHNDYRLIPSAIVQYKKWGSTIFYQSSTKVLNGQLLRKSPSAAYVELTYK
                     PVKNMTALLGIRYPFYNAWKSSSDTHSSALVSRQLSESIKDNANMIYLQFVYNFSFGKQ
                     STNVKKNMSNTDKDSGILSQE"
     CDS             complement(17496..17564)
                     /locus_tag="ctg73_14"
                     /transl_table=11
                     /translation="LFVNYSLQIFCCSAAFQAVAPR"
ORIGIN
        1 taaattaata gcaaatgcat tatctgtatt accagcggta atagtccagt tttggaaatt
       61 ggttccataa tctggatctg ttgctaaaac agtaccaact acagtagcat ttgcagagtt
      121 ctcatcaata gcaaatgatt gatttggagt aacaacagga ttttcatcat taaccgcact
      181 tacaataatg gaaactgttt gagctaaact tgtgtttact ccatccgaaa cagttaatgt
      241 taaagtgaaa cttggattaa cacttgaatt taaacctgta ttatcagcca ccgtaataac
      301 cccagttgat gaatctattg taaaatatcc accatcattt ccagcagtaa ttgtccaatt
      361 ctggaaagtc gttgcagtta catcaccatc agttgctaca actgtaccaa cagtcgttcc
      421 atttggtgat tgttcagtaa catagagaac ctgtgaagca gtaataactg gagtaacatc
      481 attaacatct gtaatgttga tagttatatc ctcttctgca ctggtgtttg ttccatcact
      541 taccgttacc ttaatagtcg atgaagtatt ggtttctata tcaagatcgt ctgcatcaag
      601 cactgtaatt tgtccagtta aagcatctat agcaaacgca tcagtgccat ctccgtcagg
      661 atttacattt gaagtgattg tccaattact aaacgtatca ccagcatcag gatcagtagc
      721 agaaacgatt cctacaactg ttccaacaat tgaattttca tcaatactga aactttgcga
      781 agcagtaaca acaggtgatt catttacatc atgaattata atggcatatg acttctcaaa
      841 atataaactt ccctgatcag ttgagcgaaa acgtacaaag taactactct tagtttcgta
      901 atccgggctt gatattatat gcaattcatt gccgctaata ctaaatgaag aattatcaga
      961 actccccgcc cctgcaacta atgtataggt gaaagtatta cctgcgtcct gatctgttga
     1021 acttaaagta cctattattg aattagccgc cgcattttcg tctattgagt ttacagacag
     1081 agaaatgtca gttggagctt cattcaaatc attaattgtt attgtaaagg tcttctcgta
     1141 ggttaaactg ccttgatcgg ttgtttgaat acgtacagaa taactgcttt tagcctcgta
     1201 atctggacta ttggtaattt gcaaactgct gccactgata ttgaaagaag cattgtcggt
     1261 gtcaccagca ccaactacca atgtataagt aaatgtattg cctgcatcaa catcggttgt
     1321 acttaaacta ccaactgttg aattactcgc tacattctca tctattgaat ttgcagatag
     1381 ggtaatatca gttggggttt catttacatt gttaattgtg atagtgaaag tcttctcaaa
     1441 attcaaacta ccctgatctg ttgttcggat acgtattgaa tagctgttct taacttcgaa
     1501 atcagggcta tttgtaatac gcaagctact accgctgatg ttaaacgatg aattgtctgt
     1561 atctcctgtt ccaacaacaa atgtatatgt aaaggtattg cctgcatcag gatcggttgt
     1621 actcaaagta ctaactgtgg agttagctac tacattctcg tcgattgatg tagcagataa
     1681 cgctatgtca gtaggtattt cgttcacatt gttgatagta atcgtaaaag ccttttcata
     1741 gtataaaact ccgccttggt cggttgttcg tacacgtact gagtaactgc ctttagtctc
     1801 gaaatcaggg ctattggtaa tacgtaaact actaccacta atgttgaacg aagcgttgtc
     1861 tgtactacca gtacctacca caagtgtata ggtaaaagtg ttggcaacat cctgatccgt
     1921 tgaactcagt gtgccaatag ttgagttagc tactacattc tcattgattg aacttgccga
     1981 tagggtaatg tcgctaggag cttcattcaa atcattgata gtaacaatga aaaccttttc
     2041 aaaccataaa cttccttgat cagttgaacg aacccgaacg gagaaactat tcttcgtctc
     2101 aaagtcgggg ctactagtga tgcgaagact actaccgcta atgttaaacg aagcattgtc
     2161 tgtgcttcct gttccaacta cgagtgtgta agtgaatgta ttgcctgcat ctggatcggt
     2221 tgaactcagt gtaccaatag ttgaattggc aacaacattc tcattgattg aactagctga
     2281 taaagagata tcggtaggaa tttcgttcac attactaata gtaatagtaa aagccttctc
     2341 gtatgttaaa ctcccttgat cggtagtgcg aacccgtacg gagtagctgc tttttgtctc
     2401 aaaatcagga ctatttgtaa tacgtaaact acttccgctg atgttaaacg aggcattgtc
     2461 agtactgcca gttcccgcta caagtgtata agtgaaagtg ttaatagcat cctgatcagt
     2521 tgaactaagt gtaccaacag ttgagttggc aacaacattc tcgttgattg aacttgctga
     2581 taaggaaata tcagtaggtg cttcattcaa gtcattaata gtaatggtaa aggctttctc
     2641 gtagaacaaa gtaccctgat cggtagtacg aactcgtaca gaatagctgc ttttagtttc
     2701 aaaatcagga ctaccagtga tacgtatact actaccgctg atattaaacg aagcattgtc
     2761 tgtactgcca gttcctgcta caagtgtata tgtaaaggtg ttagcggcat ctagatcggt
     2821 tgaactaagt gtaccaatag ttgagttggc aattacattc tcgttgattg aacttgcaga
     2881 taatgatatg ttggttgggg tttcatttaa gtcattaata gtgacagtga aagcctcctc
     2941 gtaggttaag cttccctggt cggtggtacg aacacgcaca gaaaagctgc tctttgtctc
     3001 aaagtcgggg ctgttggtga tacgcaaact gctgccgcta atattgaaag atgcattatc
     3061 agtatcacca gttccaacaa ctaatgtgta ggtaaatgta ttgccagcat ctggatcggt
     3121 tgaactcaga gtacctactg ttgaatttgc aactacattt tcattgatag aacttgcaga
     3181 taaagaaata tctgttgggg tttcattaac attgctaata gtgatagtaa aggccttctc
     3241 gaaagttaaa ctcccttgat ctgtggtacg aacccttaca gagtagctgc tttttgtttc
     3301 gaaatcagga ctgcttgtga tacgcaaact gctaccgcta atgttgaacg atgcattgtc
     3361 agtactgcct gttccagcaa ccaacgtata cgtgaatgaa ttacctgcat cctgatctgt
     3421 agtattcaaa ttaccaatcg cagaatttcc ggcaacattc tcattgattg aacttgcaga
     3481 aagagatata tcggttggag cttcgtttaa atcgttaata gtaattgtat aggctttctc
     3541 atagtataat gcaccttggt ctgttgtgcg tacacgtacc gaataactgc tcttagtctc
     3601 ataatcagga ctattggtaa tacgcaaact actaccgcta atattgaatg aagcattgtc
     3661 cgtatcacct gttccagaaa ccaatgagta ggtaaaggta ttgccaacat caggatctgt
     3721 agtgctaagt gtaccaacag tatagttagt agaaacattt tcgtttacag cacttgcaga
     3781 aagagataca tcggttggag cattgttaac acctcctgaa acattcaata cataatcttc
     3841 aaactctcca aaaccgactc cacttgtata atcaccacca ttaactccac ctgaatcacc
     3901 gtctagcatc actcgcatat atattagacc aactggtgct ccagccggaa ctgttattgt
     3961 tccagtaaaa gtttttgatc ctgaacccgt agcaccatac catacaaggg ggttctcgtt
     4021 agcatctaat gtaaagggag cagatgatgt accatttaca ttattttgat cccagtctat
     4081 atatactccc aaaaaatcat aagaaaggtc cgagccggta attgttatgg aaataggata
     4141 ggattgtcct aatgtaactt ctcctgctgc tatttgtgga cttctaccaa aatcggtgtg
     4201 ccatgcattt gaacctgaac caggtgtggt attattaata cccgcaaagg ttacattcgt
     4261 aatgtagtct ccataagtgt gacaagtagt tgtttgatca gttcctccac tttctagcca
     4321 aactacacgc agtgcagtgg gcgctgtata agcgaataca tttcctgtca ttgagaatat
     4381 gaatcccaaa acaaagaaac atttaaacaa gtttagtata acttttctca tattattatt
     4441 tattaaatga ttaaacgcac aaataaggat ttttccaccc agaaacgcat tgggtatgta
     4501 tatcataaaa cacagaatcg ttgtgtttca atgcaattcc ttgttccaac acaattctgg
     4561 atagtttgtc attatgggtt gtaattttct caatatctat aataggaggt gccaatgttg
     4621 aatcgtgatg aaaattacga aaacctcttg gtccattaac attagcatct tttatatatt
     4681 taattatttc tttcaaatct tttctttgaa gaattggtag catgggtaga aatagctgcc
     4741 ccatttcata acccatcaca gcaaattcac ttgctttctt accagtactg agatgataag
     4801 cacttttgaa tcgctgattt ttttcaacca tcgaattata gttccaagtt gatgcagagt
     4861 atagcgttat attacttttt ggtacattat ccagtgtttc atcagaggcc atgtaaggtg
     4921 ttaccactaa tggtattttg ttgtaaatat ccgattggca gtaacattta taaaattcaa
     4981 aggcttccga accacaaaac agagcatgta agtaatcaac cttactttgc ttaatttttt
     5041 cgaaaaatgg aggtagtaaa tcctcaatat taggtagctg tgggttaaat ggcagaatat
     5101 gcatatcaat ctcctcagca cctgccgata aagcaccctg ccaaaatgcg ctatgcattt
     5161 ggtaacccgc ttcatatatc gacattagaa tagccccttt ccctgaaaac tgtttctgag
     5221 cccagagacc caaagcatat tctacctgcc aaaattgaag gctgttaaaa aagatatttt
     5281 ctgatattgg agtcaacgga ggtaaatact cccctaaatc aaagaaaaaa gccaacttct
     5341 tttgtttctc taatatcgaa ttgatttctg gcattagttt atagctaaca atgcctgaaa
     5401 taatatcaac attatgaaac ataattaatt tatttaccgc aaccttaacc aattcatggc
     5461 tccctttatc aatatattca ggataaaact ggaaattctt cctataaatt tctggtattg
     5521 atgtaaaaaa accatcaatt atatcctgcg acatatgagg agcaacagat gagtaaggaa
     5581 aaagaaaacc tatttttatt gtttgattca ttaccaacta ggtttataaa gaggtcgctg
     5641 gtaatattat taaccagcga ccaaacaata ttatggacgt gtaggataaa tcccttgagt
     5701 agctatacag taattaagaa ctgtaaaagg ttgcatattg ttatgaccaa tactttgtcc
     5761 tgcatttgcc actgcaacag tacccgtaac agcaccaccc cctacattaa gggcaacatc
     5821 aggtgctgtt ccattgtaga gtgaacctgc agaaagagca ccaagtgaat tagctcttgt
     5881 agtagggcta ccacttgaac cttgagtaat atttgccttt attgtaacgg agttaccagt
     5941 aaaaactgca gtatgactgt gtattggcat ctcattttgc gataaagcaa cctgctcaac
     6001 accacccatg cttgcaaaag gtcttggagt taagcctgta ccgttgccct gcccaagaat
     6061 tgttctaccc tttaaatcgg ggataccaaa tgtttgagtt ccatttccac caaaatatgt
     6121 tcctaataag gaatacaaag cggagttttg tgaaatttgc aggattgagc catcacaaat
     6181 ctgaaagccc attggcgccc aaccaaatgc aaatgcaaga atttgtgcca tgtaaggatc
     6241 catagtctaa ttttttttta gttaataatt aagttatata atctaaaatt ttagattcaa
     6301 tttttggttt attactctgg ttataccaaa attcaattga ttttgggcaa ttatctcgca
     6361 attcaaaata ccttaaaggc atatttaaac tacaatcgtt taattctaaa acctcattac
     6421 cgaatacttt aattgtggta taaagcaata gatcgtaagg tttatcagat gtatgcggca
     6481 aggtcaccac ttttcgatag ctattgctat ctaaatttgc tttactcaca gtaaacaact
     6541 cacataaatg atttgtctct cctccttctt ctaatagctg atccccattc caaatgcctc
     6601 ttctctttaa ataggcatca attttaattt gctcgggaat aaatatggta tcggatttac
     6661 attgaggtgc tagattttgg gttattgcca cctgtggttc attctttagc cctgcttgca
     6721 tcgtttcaga gatcacaata tcataggagc gatcaacttt ataggttgcg gcatcagcta
     6781 aaacaaattg atcaatatag ccgcccaaac aaagctcctt tatgagcttt tctgctgagc
     6841 ttaatgatac actgttaaca tctaaaagtg taacactaat tctatcagca gaataatagt
     6901 gaagtaaagg ggtaatcagc gtagcgtaag ggccacatcc cgcatagagt attttaacct
     6961 gctccttacc atcacccatt tttgaatcga ttgcttgctt tatcccacgc aaaaaaattg
     7021 ctgtccgttt catttctaga aggcaatgcg ctgctccctc tggagatata gcttttccag
     7081 aaggaaggtg aatatcacca tcactccaat tagtaaaatc gatacctgta attgatttga
     7141 atagttgata caaactatca acggactgtt tcattttctg aaaatcattg ccacaactga
     7201 ttagcgtatc agtggcaact cttgctaaat tgatgttggt tgagccaacc atttagtatt
     7261 ctctttaatt taataaaaaa caacaaccta aattctaaag atttattgcc tttattcaat
     7321 caaaacgaac tagcaatcgt gaaaatcaac acacttaata aaacccaact tcgcaatgtt
     7381 ttctttttct atcagagata aattttcaaa acaccatatt cttattttct tcaaaaagca
     7441 tatcgctgtt ggtcaaataa aaactataaa ccattcttcc caataataat tgataaataa
     7501 tcatccacga aaacaaaata tttcataaat gatatcaata tcccatttta aattaaatat
     7561 tagagcagat aataatcact ttacttttct ataaccacca gtaattcaaa tcataaaacg
     7621 aatcaacaat ttgatataaa ttaggcaagt gaatgtaagc catttttatg acaatttgca
     7681 aatattctta aatttattta tgtacatatt cctagtacaa ttaatgatgt tatttcaata
     7741 ttttagagct aacaaggaag tataagcaca ataaaagtaa ataacctact tgtatgaaaa
     7801 aaacacaatt tctgggtgga ataatggtaa actaaagtga attcacaacc aaaattttag
     7861 gtctaatgca attaggacca acaggatatt tgacgattca gaaaaagttg tttaatttta
     7921 gaatcatcag aatggctagg taacattaga aaatgctata aataagtttg tgtttaatta
     7981 aaaaaacttc tatcatcaag gcaaacgcat tttaaaattg aatagcactt ctctgtattc
     8041 agaatttagt gctgctttaa gtcgcttttt gcatgcttta aattacctgt cttcgaaaag
     8101 gttatctttg caattgtatt aaaagtacca tagctatttc ccatagtagt ccttcctaaa
     8161 agtaacatta tgtatctggc gaaggttatt ttcaatcacc caatggtttc tgacttattg
     8221 gttgagttgt ttgtccgttg caagcctact gaagatatag tattgggtcg gataggtcag
     8281 tttccctgca atttttatga ttctccggga gtcaatacag acaattgctt ttaattcagt
     8341 ttattcatgg gcattctata aatgcatgag agtttataca ctacactggc aggtttcata
     8401 ctcctatgtt cgcaatcaaa ctctttacgt gcatcaatgg gcttttcaaa acaaacggta
     8461 tcgaaaactc tcacctcaaa aaaaaggtta attgtccttt gcagccagaa tgtagtcgtc
     8521 tctttggtcg gtattttgga tgatttgatc ttttgacatt ccatggcatc gctggtgacg
     8581 atacgtccaa ccaagcttag caaaaaaggg agtttagatt taaccgtaat tccgctgctc
     8641 ttacccgaaa tgactgtttg cccaaagcac ggatcgcttt tcgtagcaaa gccctatacc
     8701 catgaatggc tgaacgccca ttgtccatat caaataagtt acagattctt tttctgatag
     8761 ttgccttaga tcctgaccca ctcaataaaa cattgcctga atgctatgga atcaatgtcc
     8821 gaaaaaacac cgttgataat atcgtagagg tatgctgaac aaccagccct tctgattgcg
     8881 atcctacaac cagatttcac atccctcgtt cgccccgaat aggatattcg ataacaccga
     8941 aaaaaataat atcgtaaacg tctattattt gaaagttaat ttgtccactt attaattgag
     9001 cagatagagt aaacaattgc caaataattt taacaaatta ttgacattta ttttttagaa
     9061 aaacagaggt ggagaagccg tcccgtaaac tctagtgttt caaaaaaaac acaaaacata
     9121 atgataaatc atgagggctt ggcatcttcg agagtaatat aaactaagga aaattctatt
     9181 ttttaaatac gtttaaccag ataactcagc agaaattttt ttccatagtt atttttattt
     9241 tccatagtta tttttatttt tacttaattt atttaatatt ttacatctat acttaaacta
     9301 tttatattta ttgtaaattg aaataatgca cctgtttttt aatatacaag acaattcttg
     9361 tcctagatta gggaaaaata gatttatcta gtttagccac ttttattgat aatgcctaat
     9421 cttatttctc ctcagttaaa agtggcaata acccaactga acactttcag tataattaaa
     9481 taacctaata gttattgtta gcatgaagga gaattatttt tagaattaca actttaaaaa
     9541 gaaaaggaag aatagttgat aatttataaa tattaaatat tatgaacgaa aaaaaacaat
     9601 tcacacaaga ggatttagag caaatcctag gtggaacaac caatacaact ggaactacat
     9661 ccacatgtgg aactattgag agtgacaaat tgagtgaccc aagtaaagca actacaacag
     9721 gtgcttctcg tactggggct cagcaagcag ccgtaagcga taatttgact taatcattta
     9781 gaaaagaggc tgtttaacaa gtttggacag cctctccatt aatgatattg gattcaatct
     9841 gaattcgact tcaaacacgc aattttcaga gccattattg tctttactat aaaaaatatc
     9901 tatttgtaaa ctccctgtta atcaattgca ttagttgtga aatttccggc aattcactat
     9961 aatgttaaag taaatttcct acatacaaag agaatatgat atgaaaaaat acaagttatc
    10021 aaaatacaat gtttttgttg acaaagatcc caaagggttt atttataacc ttttgtcaaa
    10081 tgaactattt tcttttaaac acgaactctt taattacttg aaaaattctg aaggaacagt
    10141 agatgaatca actttaaaac ctgagcttat taatagtcta tacagcagca atatcatttt
    10201 agacgaaacc gaaaatgaaa taaacatgct acattatgac tatcataaag ataaatatga
    10261 cgactcattt atttcacttg ttatttatgc aactttaaaa tgtaatttta attgtcatta
    10321 ttgttatgaa aaacataaaa atatttcaat gtcagatgaa aaatttgaca ttttaaaaca
    10381 atttttgatt aaagaaagtg ctacaagaaa attcatcgct actaggtggt ctggaggaga
    10441 acctttatta gtgtggaaaa aaatatataa cacatcttta gagattattg atgcatgtaa
    10501 aaaaaataat tgcaactata tatcttcaat tgtttgcaat ggctatctat taacagaaac
    10561 catattagat gaaatgttat ccgttcacat aaattctatt caaataacat tggatggcaa
    10621 ccccgaaaat cataatcgcg taagattctt aaaagacgga actggaactt tcgatagaat
    10681 actacaatca attgagatgg cctcaaaacg tatgaaagta atcctaagac ttaacataga
    10741 taaaaacaat attcatcaat tcaatgaatt atttgagata ttaagtaaaa gcaaaatcaa
    10801 caaatcaaat gttcggatat tctgtaaacc agttgtttgt acaattgcta gaattcctga
    10861 aaatccattg tttagccatg aagagtttta ttctgtagag aaaaaactta ttgaatcagc
    10921 cacaaaaaat gatttgattt attcttttca ttggggtgta aaatcaagaa aaacaagatg
    10981 tgtatatcat acattaacag gatttcttgc agatccagaa ttgaacttat ttaggtgtcc
    11041 aatatatata ggaggcgact tagaacataa ggttggacat attgacaatc aaggattgca
    11101 tatcaccaat cgagaggaat acttaaaaac gctatcctac tctccctttg acctccaaga
    11161 gtgtaaagaa tgtaaagttc ttccaatatg taatgggaaa tgtcccgttc tttgggaaat
    11221 atcgggtcgg aaaaaggagg aaggatgtat tcccgacaaa tattcattcg agaaaaaact
    11281 gaaatatgcc attgagaatg aacgtcaact agaagcatta agaaattcaa caattaatta
    11341 aaaacgaaat ataagacaaa cattatggtc gcactattat tttgtcctgt taaaggaaat
    11401 acaaattacc cgccactttc agtttcacta ctttcatcgt atttgaagaa aaatggagtg
    11461 aattcttctg ttattgattt aaataaagcg ttatatctcg aaaatgaaga attagcagca
    11521 aattatagtt actattttgc ttttccatca atattttcag gatacactga taatgaaaat
    11581 gaaatcaaaa acgttgacac aatctataac ttctcattgc tattatccat attgtacggg
    11641 agtgataaat taccgtatac ttataataaa gaagaaaaag aatttgtaca acaacttgaa
    11701 caagaaattg actctaaggc taatctaatt acaaactcaa actataaata tattggtttt
    11761 tcaacctatg taagtaatat tgcttactcc tgcattttag caaaaaaact taaagaaaaa
    11821 aatccgaaca tctctctttt ttttggagga agttcgacat ctttctctcc cataagagaa
    11881 tttcttttag aaatgaaact tgcagactat gtgatagtgg gagaaggaga agaagcattg
    11941 gttaaattga taaatgacct tgaaagcgga tcacaaccaa attataatac cattttttcc
    12001 gaaaacattg ctccagaaaa tccaaaaaat aatgaaacaa ttgttcccat aatttctagt
    12061 ttgaactctt tgccattccc tgatttttcc gattttattt tatccaatta ctcaccaaaa
    12121 aataaggatt atacaatact gccaatttct tcatcaagag gttgtattaa tcagtgcgtt
    12181 tattgttcgg aggcccaata ttggcaaagg tttagacaac gaagcgtaac caatgttgta
    12241 aatgaaatca aacatggggt tattaaatat aatgcaaaat gttttttctt tcatgatagt
    12301 ttgatcaacg gaaacattaa atggttggaa gatttttgcg accaacttat tgaagaagaa
    12361 ttaaatattc attggttttc ttttgcttca gtacaaaatt tgaattttga gatactcgaa
    12421 aaaatgcaaa aagctgggtg tatatctttg acatatggca tagaacatat tagtgagaag
    12481 gttctaaaaa atatgaataa aagatcttca cttggaaaag ctaaagaaat actggaagct
    12541 agtgtagaga taggtattat gcctactgca aatattatat atggtctttt aggtgaagat
    12601 gatgaagatt ttgcgaatct actttatttt atatccctcc ctcaatttcg tgaaaaagta
    12661 tattttacat atagagcatt tgaaattagg gttggttcaa taatttcaaa taagattatt
    12721 gaggaaatgg atgatattaa gattagaaag agcaacttct ccaagtttaa tgaacagcag
    12781 aaaaaaatat tctcaaaaat tgatatttat tggctgccaa attctgaata tgtgagcaag
    12841 ttaatgctaa aactaaatgt aataaataaa ttcattagag aacaagaagg tactttgaat
    12901 actaaacaat cgataatcag aaactacgat actactccta tattaaagtc gattgtaact
    12961 ctaaaacaat atccattagt agtttgcaac gaatcagaaa tagatggagt tttatacggt
    13021 ttatctcatg tacagaaaga aatagtctca ggtgcgtcta aaaagcagaa tttattagag
    13081 atttctgatg caatgtacgc taagattacc acattgaacc cttcaagtat ttataattcc
    13141 gatgaagtaa agaaaaccat taatgaagca gtaattgaaa aagcaatttt attaacgcaa
    13201 aaaggaataa taaaatggaa gtaaaaagat ttaaacgata taaagcaaag tctccgaatg
    13261 aaactattaa tgaaatacga aatacccttc ataaattagg aatattaatg aaagaagagc
    13321 attttaaaga caaggattca atgttttatt cttgcagtat tttcatttgt aacgaagggt
    13381 tggatgaata taacttaggc tgcaatggta aaggtatgac tgcggagtat gctttggcta
    13441 gcgcatatgg agaatttatg gagcgattgc agaataattt gatatttatg catcaggatt
    13501 ttgcaaagtc aaaattctta tcccaattaa aagaaaatca accatttttt tataacaaaa
    13561 ttcatgatga aaaccttttg ttgaattata actttgctcc cgatgaaagt tataccaaat
    13621 caagtaccga aaataaggaa attataaatc aattcattac caatcctgac acatattata
    13681 atggattgct tgaagacgaa aagttaactc ttctgccgtt tttcaatgta tttgaagaaa
    13741 aaatagaaaa actccccatt gaattgataa ttcataattg tacttctaat ggaatgtcgg
    13801 caggaaatac ccctaaagaa gcacttatcc aaggattatc tgagatattc gaacgctatg
    13861 ctatacgtct tatttataaa gaaaacctgt cattaccaag cattcccaaa gagtatttta
    13921 aaggaaccaa gatttatgaa aatatcattc acctagaaaa agaaaatggt tgggagattg
    13981 atataaaaga ttgctcgtgc ggaaaaaaaa ttccggcaat aggggtctta atacatgata
    14041 aaataaacat taaacatcaa tttcatattg gggtagatcc ctctccgatc actgcattgg
    14101 aaaggtcgtt aaccgaaatt tatcaaggaa gaactgatgt tttatttcat gaaattgatt
    14161 tggcttatca aagccgactg atgacagaca tggatttaaa agaaacagag atgtttaaaa
    14221 catatgttga ctcacggggt atttatccaa tttctttatt ttcaaaaaac tataaatatt
    14281 cattcgaagg cttcaacagt gatcttggtc tttctgatga tagtgatttg aattacatga
    14341 ttgaaactgt taaacaactt gggtttaaaa tgtacattag gaattcttca tttttaaatt
    14401 tccctgcatt ccatgtctac atacctggaa tgagtgagat taagaatgtt ttttctagca
    14461 cccattttaa tagacaatac aaaaaaacaa gaaattattt tttaacagct cataatcttc
    14521 caaaagcatc aaatacagaa attgaaaccc tccttgagta tatcaaatgg gatgaaaaga
    14581 atgtgaatgt gatgaagttt tttaataaca aagatgggtt acttacaaaa gataccgatt
    14641 tagttcttgc tgtattgaat ataaaaattg gaaataatag agaagctatt aagcatattg
    14701 ataaatatat cgaaagtatc aaaaccattg aggggattac tttctttaaa tgtataaagg
    14761 atattctttt tgttaaggat aataataata aagaatttat tgagttgatg aataaaattt
    14821 attctccaga ggtaatcaaa aatgcatctt cattcataga ggaaaaaaat attcttgatt
    14881 attttaattt cagctcatgc tttgaatgtg ataaatgtaa aatttattca tcatgttcct
    14941 tttttaacgt tttaaaaatt gcaaaagaag tcgaggttgc atttaaaaac aatatcctcg
    15001 atcaatcaat gattcctcaa tatattaatt aacttcttta gatatgaaaa aaatcttttt
    15061 aacggtactg ttaggaatac ttacacatat tgtcaatgct caagaattcg taataaaagg
    15121 aagattgata aatcaagaaa aatctcctat tggaaatgca agtatagtct tgaccaaaaa
    15181 tgaagttgaa acaccagtgg taaaagcagg aacaagtggt aatgatggag gtttcgagtt
    15241 ttctaaaata cgttctggcg aatacatcct aaaaatatat tatctaggat atgctaaaaa
    15301 agagataaat gttcaactga aggatagcaa tatcaatatg gaggatatag tgctaaatga
    15361 acaaacccaa gatttaagtg aagttgttgt aactgcaaat agcgttagta gttttgccga
    15421 aaaaaacaca taccgaccta caactatcga tagacaatcc tcatctaatg cattagatgc
    15481 attgaaatca ttgcccaaat tgcttgttgg aatgagcgat caaattctaa ctacaaaagg
    15541 agagcaggtg aaagtattat taaatgggat taacgcaact gaatcggatt tgctatcaat
    15601 acctcccgac aatattgctc gtatcgaata ttatcaaacc ccaccagcaa gatatgcttt
    15661 actgggaatt ggtgctgtgg ttaatgtaat aacaaaagat aacgtaattg gcgggcaagt
    15721 tgcaaccagc cttcaaaatg cattaacaac agggtttggc aatgatctgg tgaatttcaa
    15781 atacaacttt ggtagctccc aaataggaat aaagtataac ttaagttatc gtgactatag
    15841 taaaaggact gcagatgaat tactaaatta taattttaat ggtatagaat acaataaaaa
    15901 taagattggc tataatagcc catataacta tcaaaatcat gtttttgagg ttaatttcac
    15961 gaatcaaaag ccagataatt atgtgttcaa cacaatcatt tcactaaaca aattcgatca
    16021 ggataaggag actgggcaaa atgtggagca aatgtcacca acatatatgc taaattctgc
    16081 cctaaataaa gaaaacaaca aatatcttaa accgtcaatt gatttatact ataccaagaa
    16141 aatagacaaa gttcaagaat tatccatgaa tgttgtaggc acttactatg atgcaacatt
    16201 tataaacaag taccttgaaa aaacggctac tagcgacact aatttttact cagcaactaa
    16261 cataaatagt gataaatatt cgcttatttc agatgcaata tactcctact ctttggagca
    16321 cgaaaagatc tcggttgggc ttagaaatat gtatggatac tctaagcaga atgttttaac
    16381 aacaggaaca gaaaacctta catcaaatca aaatgacttt tatggatttg ctgaattaac
    16441 aggtaatcgc tctaaattat cctattcact aagtgctgga ttaaatttta gcacttttga
    16501 tagctatgaa ttggataaga actattcata tctctatttt agaccgatta taaattttcg
    16561 ttatgagcta aatgacaaat cagatatatt cctgtcatat caaataaaca cacgtaatcc
    16621 atcattaagt gaattaagca aaaatcctgt gatgcaagat tactattttg cgtattgcgg
    16681 taatccaaac ctagaaccat tcaccacgca ttccactatg ctatcatatg gttatatggc
    16741 tgataatttc aatttttcaa tcgacttttc ttttgattat tccaacaacc ctatactacc
    16801 atatttcatt actcaaccta gctatattct gcaaacatac tccaatctcg aagatgcaaa
    16861 aaaatatagc atttctttat ttacccaatg gtttccgttt aaatcaaaat ggttaagatt
    16921 acgtctttcc aacgaaatgt ttagaaatga aaatagggga gttgattttt catggtcaca
    16981 caatgattat cgcctaatac cttcagcaat tgtacagtat aaaaaatggg gaagcactat
    17041 cttctatcaa tcatcaacca aagtattaaa tggacaatta cttagaaaat cacctagtgc
    17101 agcatatgtt gagctaacat ataaacctgt aaaaaatatg acagcactgt taggtatccg
    17161 ctatcctttt tataacgctt ggaaatcatc atcagacaca catagttctg ctttagtttc
    17221 acgacaacta tcagaatcta ttaaggataa tgcaaatatg atttacttgc aatttgtgta
    17281 taacttttct tttgggaaac aatcaacaaa tgttaaaaag aatatgagta atacagataa
    17341 agactcagga atacttagcc aagaatagat attatatcac tgctgtccga taaaaaaaat
    17401 gcaatctcat aaaacagatt aacaacaagg ctttgaaaaa tattacgccc ctacagggat
    17461 tatttttcta ctagtaatct ttctttctac aaatattatc gcggtgctac cgcttgaaaa
    17521 gctgcagagc agcaaaatat ttgtagtgag taatttacaa atag
//
