LOCUS       c00050_3300000..       10683 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300000234.a:TB_GS09_5DRAFT_10006507.
ACCESSION   c00050_3300000..
VERSION     c00050_3300000..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 12:27:54
            Original ID  :: 3300000234.a:TB_GS09_5DRAFT_10006507
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10683
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10683
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:3736](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2..3736
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..10683
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10683
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             2..3736
                     /NRPS_PKS="Domain: AMP-binding (175-588). E-value:
                     2.4e-107. Score: 350.7. Matches aSDomain:
                     nrpspksdomains_ctg50_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (699-768). E-value: 4.8e-25. Score:
                     79.3. Matches aSDomain: nrpspksdomains_ctg50_1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (783-1082). E-value:
                     5.2e-101. Score: 329.3. Matches aSDomain:
                     nrpspksdomains_ctg50_1_Condensation_LCL.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     344.6; E-value: 1.3e-104)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_1"
                     /sec_met_domain="Condensation (E-value: 3.1e-75, bitscore:
                     242.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-113, bitscore:
                     368.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.5e-16, bitscore:
                     48.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="GFFVNSLVLRDNVTAHESFTMLLPKVKQTMLDAVAHEIYPFDRLV
                     EELAQGRDLSHNPLFDVMIAMDDRADVAPLLKKFNLQEIPLGTDDGQFDLTFSITEQSE
                     TIDILVAYNTDLYLSGTIERMSQHLYTLLSDVVARPQCPISQLQLLTEAETQAIIQFYQ
                     PVNLVQSGLHHLVEWQVELTPDAIAIQFENQLLTYAEVETQANQLANYLLSLGVQLGDF
                     IGLTIERSHLVPISLLAILKAGGVYLPLDPAYPQDRIAYMLEDTQAKILLTQQDINLSS
                     LSSQVKVVCLDNDFAKIAACDPQRPNITISSNNLAYVIYTSGSTGKPKGVMISHQSIAQ
                     HYQDIQQLYQLNVHDKVLQFASISFDTSLEQLLPLTQGSCLVLRGRELWSSVEFVQKLL
                     DYQITVADIPPEYWRALAQEVENLKETHENSAQLKLRLMIVGGEAMSVEDLRQWRETSL
                     NHVKLLNAYGPTEATIEATVFDIPSDYHLNPHLTKISIGKPLASRRIYILDKQNQIVPT
                     GVAGELVIAGCLAEGYLNNPKLTAEKFIECEFNLAGHKIVEKVYKTGDLARYLADGNIE
                     FLGRIDNQVKLRGFRIELGEIETALNQHAQVQESIVILREDQPRIKYLAGYIRLKTVLV
                     DTSEIEAELRDFMKQQLPEYMVPTAFVFLDNFPLTGSGKIDRRALPVPNLQKFNKNIVT
                     ARTSLEQHLVTLWAEVLKLPQVGIFDNFFDLGGHSLSANQVVSKIHKTLAKKLMLKEFF
                     THPTVAEIAELLEKRGRSDLPPIQPIASQPHYPLSYAQRRLWTATQMTGDSAAYNMVGG
                     FILSGNLNVAAFKQCFNSLIARHESLRTRFITVAGEPRQEILPTLAFEVIEADISHQAE
                     EAAQSLFYQELQATFDLRQVPLLRVKLLKLPSDSTPRHLCIVNMHHIIGDGVSVEVLFK
                     EIIQLYRDLTENRPNSLQPLRVHYKDYVFWQGAMLESEEGQQHRNYWLQQFSDEIPVLD
                     LPTDFPRPAVQTQHGEMLKFFINAELTRSLYELNKQQSVSLFMMVVSLVNTMLYLYTQQ
                     EDIVIGSPVAGHNHPDLEQQIGFYVNTLALRTRFSGSDNFVDLLAKVKQVATDAYVHQD
                     YPFDKLVEELNLQRDLSRTPLFDVMVILQNYEPVSFDLPNIAVQSFMDDASVTSKFDLN
                     LMFEQIDDQLGVWVEYNTDLFKRTTMEQFAENFIKLVQSVTKNPVQELNYFKTLFVAIH
                     EQQEQSQFLQAIDEISDDF"
     CDS_motif       80..196
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0001"
                     /evalue="1.30E-17"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg50_1"
                     /protein_end="65"
                     /protein_start="26"
                     /score="56.1"
                     /tool="antismash"
                     /translation="KQTMLDAVAHEIYPFDRLVEELAQGRDLSHNPLFDVMIAM"
     aSDomain        527..1765
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg50_1_AMP-binding.1"
                     /evalue="2.40E-107"
                     /label="ctg50_1_AMP-binding.1"
                     /locus_tag="ctg50_1"
                     /protein_end="588"
                     /protein_start="175"
                     /score="350.7"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="VEWQVELTPDAIAIQFENQLLTYAEVETQANQLANYLLSLGVQLG
                     DFIGLTIERSHLVPISLLAILKAGGVYLPLDPAYPQDRIAYMLEDTQAKILLTQQDINL
                     SSLSSQVKVVCLDNDFAKIAACDPQRPNITISSNNLAYVIYTSGSTGKPKGVMISHQSI
                     AQHYQDIQQLYQLNVHDKVLQFASISFDTSLEQLLPLTQGSCLVLRGRELWSSVEFVQK
                     LLDYQITVADIPPEYWRALAQEVENLKETHENSAQLKLRLMIVGGEAMSVEDLRQWRET
                     SLNHVKLLNAYGPTEATIEATVFDIPSDYHLNPHLTKISIGKPLASRRIYILDKQNQIV
                     PTGVAGELVIAGCLAEGYLNNPKLTAEKFIECEFNLAGHKIVEKVYKTGDLARYLADGN
                     IEFLGRIDNQVKLRG"
     aSModule        527..2305
                     /complete
                     /domains="nrpspksdomains_ctg50_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg50_1_PCP.1"
                     /locus_tags="ctg50_1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       713..754
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0002"
                     /evalue="2.30E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg50_1"
                     /protein_end="251"
                     /protein_start="237"
                     /score="17.6"
                     /tool="antismash"
                     /translation="LAILKAGGVYLPLDP"
     CDS_motif       947..1006
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0003"
                     /evalue="1.30E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg50_1"
                     /protein_end="335"
                     /protein_start="315"
                     /score="36.1"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVMISHQ"
     CDS_motif       1547..1633
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0004"
                     /evalue="4.30E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg50_1"
                     /protein_end="544"
                     /protein_start="515"
                     /score="38.2"
                     /tool="antismash"
                     /translation="PTGVAGELVIAGCLAEGYLNNPKLTAEKFI"
     CDS_motif       1730..1795
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0005"
                     /evalue="3.00E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg50_1"
                     /protein_end="598"
                     /protein_start="576"
                     /score="38.4"
                     /tool="antismash"
                     /translation="FLGRIDNQVKLRGFRIELGEIET"
     aSDomain        2099..2305
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg50_1_PCP.1"
                     /evalue="4.80E-25"
                     /label="ctg50_1_PCP.1"
                     /locus_tag="ctg50_1"
                     /protein_end="768"
                     /protein_start="699"
                     /score="79.3"
                     /tool="antismash"
                     /translation="EQHLVTLWAEVLKLPQVGIFDNFFDLGGHSLSANQVVSKIHKTLA
                     KKLMLKEFFTHPTVAEIAELLEKRG"
     aSDomain        2351..3247
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg50_1_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="5.20E-101"
                     /label="ctg50_1_Condensation_LCL.1"
                     /locus_tag="ctg50_1"
                     /protein_end="1082"
                     /protein_start="783"
                     /score="329.3"
                     /tool="antismash"
                     /translation="HYPLSYAQRRLWTATQMTGDSAAYNMVGGFILSGNLNVAAFKQCF
                     NSLIARHESLRTRFITVAGEPRQEILPTLAFEVIEADISHQAEEAAQSLFYQELQATFD
                     LRQVPLLRVKLLKLPSDSTPRHLCIVNMHHIIGDGVSVEVLFKEIIQLYRDLTENRPNS
                     LQPLRVHYKDYVFWQGAMLESEEGQQHRNYWLQQFSDEIPVLDLPTDFPRPAVQTQHGE
                     MLKFFINAELTRSLYELNKQQSVSLFMMVVSLVNTMLYLYTQQEDIVIGSPVAGHNHPD
                     LEQQIGFYVNTLALRTRFS"
     aSModule        2351..3247
                     /domains="nrpspksdomains_ctg50_1_Condensation_LCL.1"
                     /incomplete
                     /locus_tags="ctg50_1"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2414..2527
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0006"
                     /evalue="4.50E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg50_1"
                     /protein_end="842"
                     /protein_start="804"
                     /score="54.4"
                     /tool="antismash"
                     /translation="AAYNMVGGFILSGNLNVAAFKQCFNSLIARHESLRTRFI"
     CDS_motif       2744..2809
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0007"
                     /evalue="7.40E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg50_1"
                     /protein_end="936"
                     /protein_start="914"
                     /score="28.1"
                     /tool="antismash"
                     /translation="MHHIIGDGVSVEVLFKEIIQLYR"
     CDS_motif       3149..3238
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0008"
                     /evalue="6.80E-14"
                     /label="C5_LCL_267-296"
                     /locus_tag="ctg50_1"
                     /protein_end="1079"
                     /protein_start="1049"
                     /score="44.2"
                     /tool="antismash"
                     /translation="DIVIGSPVAGHNHPDLEQQIGFYVNTLALRT"
     CDS_motif       3287..3400
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg50_1_0009"
                     /evalue="3.50E-21"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg50_1"
                     /protein_end="1133"
                     /protein_start="1095"
                     /score="67.6"
                     /tool="antismash"
                     /translation="KQVATDAYVHQDYPFDKLVEELNLQRDLSRTPLFDVMVI"
     CDS             3767..4837
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) pgm_amidino"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg50_2"
                     /sec_met_domain="pgm_amidino (E-value: 6.8e-95, bitscore:
                     307.3, seeds: 95, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKLPVVNSHNEWDTLEEVVVGVIDGATVPSWHIMLQATMPTTQW
                     DFFKQFGGQPFPKERIDAARQDLEECVHILEQEGVKVTRPDRVDFTKPFSTPEWQSAGG
                     LYAAMPRDLLIVFGDEIIESPLSWRSRHHEIGAYRRLMKDYFRQGGKWTCAPTPQLLDD
                     LYDADYIEPEEGEPHRYVITEFEPVFDAADFMRCGRDIFVQLSHTTNQFGVDWLQRHLG
                     EGYRIHQIEIKEQSPMHIDATFVPLAPGKLLVNPEKLAKVPEXFKHWDVFYAPPPCTPV
                     EHPMYMSSRWLSMNVLSLDEKRVMIEKGEETLIRDLKKWGFEPIPCSFRNFYSFGGSFH
                     CATLDVRRRGTLQSYF"
     CDS             complement(5062..6843)
                     /locus_tag="ctg50_3"
                     /transl_table=11
                     /translation="MRSHYCGHLNETSIEKTVTLCGWVHRRRDHGGVIFVDLRDREGLV
                     QVVFDPTLAEAFGTAERIRNEYVLQVTGTVRYRPEGTMNQNLSTGQIEVAVQTVTILNT
                     SETPPFQLDDDNTSEETRLRYRYIDLRRPQMQERFKLRAKVNQIVRNFLDNQNFLEIET
                     PMLTKATPEGARDYLVPSRTHPGEFFALPQSPQLFKQLLMMSGMDRYYQIVRCFRDEDL
                     RADRQPEFTQLDIEMSFIDEIQLRDLMEAMIRHLFKTTLAVDLPEPFPCMTYAEAMQHY
                     GSDKPDLRNPLELVDIADLLDSVEFKVFAAPAKDPEGRVAALRVPNGKELSRKQIDDYT
                     AFVAIYGAKGLAYIKVNDLQKGKEGLQSPILKFLPDDVVTAILARVQAVDGDVIFFGAD
                     KAKVVNEALGALRLKIGEEMKLTTPGWKPLWVIDFPMFDWDDKEKRWVALHHPFTAPNI
                     ADLTVLEQNPGASLSRAYDMVLNGSEIGGGSIRIHHPDMQSTVFRMLGIGEAEAREKFG
                     FLLDALKYGCPPHGGIAFGLDRLVMLMTGANSIREVIAFPKTQTASCPLTSAPSAASEF
                     QLKELGIRLRTAPKVDV"
     CDS             complement(6946..7197)
                     /locus_tag="ctg50_4"
                     /transl_table=11
                     /translation="MPTYEYECNSCGHKLEAWQKMSEDPLTECPQCHQAALRKVLSAVG
                     GFHLKGSGWYATDFKDKKSNPCGGNTETCPACPAATTS"
     CDS             complement(7394..7996)
                     /locus_tag="ctg50_5"
                     /transl_table=11
                     /translation="MLQALFKAILLSVLFLVNMAVFTWFLSYLEVGKPTLEKTPLISNV
                     QAGYAAPKRPVAIVTQNPIQQPAAPMPVTQPSAAKPKTSVLQPIQSVKQSKGIAAFQRT
                     SLQFESISTQFVPSEQIKLETALQESHISPSHRVVILVGPAPSESNTTSPQTSKLRAQT
                     VARLIYAYTQNIKMLYHPEMEIGRVDVEFYSPKIAKN"
     CDS             8280..8603
                     /locus_tag="ctg50_6"
                     /transl_table=11
                     /translation="MTYVVTDNCIRCKFSDCVDVCPVDCFHEGPNFLVIDPEECIDCTL
                     CVAECPANAIMPADDVPESMQHFIELNAELSKIWPVILEKKQPLLDAEQWNGRTDKLQF
                     LER"
     CDS             8863..9447
                     /locus_tag="ctg50_7"
                     /transl_table=11
                     /translation="MSTKFHPSREAARILGVHPNSLRKWADIGEINYIKTKSGQRRYDV
                     DSYIGKSTTSITICYCRVSSHKQRDDLERQVEFLQNQYPTAEFVKDIGSGLNFKRKGLK
                     TILERAMSGTHITLVVAHRDRLARFGIDLIRQVIEQNGGKLVVLNETLLSLEQELTNDL
                     LNIVRVFSARMPGLRSYKKQINQIVTDSKTE"
     CDS             9571..9813
                     /locus_tag="ctg50_8"
                     /transl_table=11
                     /translation="MFTQTLPEWTKDVPFQITSKTHPETDEVKKVGSVKRIKLLNRKWI
                     NRGIVGACNVLLRALVDQPHKVTWQLADVNKINCC"
     CDS             9834..10181
                     /locus_tag="ctg50_9"
                     /transl_table=11
                     /translation="MPSKTIKNSNDRVDSSEQTTLRLSDDIGKMADRIGGMADRIGEMA
                     ERILKTQEIQAKNIELTQKSMLELMQAMTKQMEFSNRLMELMFDKGDNVPGKQLPSWQL
                     SKSTEPAKKSE"
     CDS             complement(10229..10372)
                     /locus_tag="ctg50_10"
                     /transl_table=11
                     /translation="MVELTCQIYLNRIKKGNQALTVLIQQESARQLAKLSGSQPDFECS
                     VL"
     CDS             complement(10418..10681)
                     /locus_tag="ctg50_11"
                     /transl_table=11
                     /translation="KVIFQHNISFFLFLPLLLLAIIPISLLIIAASVWRTWDNFNVWLF
                     SEKDAISVEQARQRLAENPFFEKLTPEQKQQLFSKKDLPLGL"
ORIGIN
        1 tggtttcttt gtcaattctt tggtattacg tgataatgtg acggctcacg agagtttcac
       61 aatgttattg cccaaagtga aacaaaccat gttagatgca gttgcccacg aaatctatcc
      121 ttttgaccgc ttggttgaag aattggcaca agggcgtgat ttaagtcaca atccattgtt
      181 tgatgtgatg atcgcgatgg atgatcgggc agatgttgcg ccgttgctca aaaagttcaa
      241 tttacaagaa atcccacttg gtacagatga tggacagttt gatttgactt tttcaatcac
      301 agaacagtct gaaacaattg atattttggt tgcctataat actgatttat atctttcagg
      361 cacgattgaa agaatgagtc agcatttata cactttactc agcgatgtgg tggcgcgtcc
      421 tcagtgtccc atttctcaat tgcaattgct gacagaagcc gaaactcagg caattattca
      481 attttatcaa ccagttaatt tagttcagtc cggattacat cacttagtag aatggcaagt
      541 tgagcttact ccagatgcaa ttgctattca atttgaaaat cagttgctta cttatgctga
      601 agttgagact caagccaatc agttggcaaa ttatttatta agtttaggcg tacagctcgg
      661 tgattttatt ggcttaacta ttgaacgttc ccatttagtg ccgatcagtt tgttggcaat
      721 tttgaaagca gggggcgttt atttaccgct tgatccggcg tatcctcaag atcgcattgc
      781 ctacatgttg gaagacacac aagcaaaaat cttgctaact caacaagata tcaatctttc
      841 atcgttgtca tctcaagtga aagtggtgtg tctcgataat gattttgcaa aaattgccgc
      901 gtgtgatcca caacgtccaa atattacgat ttcttccaat aatcttgcct acgttattta
      961 tacttccggt tcgactggca agcccaaggg cgtgatgatt tctcatcaaa gtatcgcgca
     1021 acattatcaa gatattcaac agctttatca actcaatgtg cacgataagg tgcttcagtt
     1081 cgcctcgatc agttttgaca cctctttaga acaattattg ccgttgactc agggcagttg
     1141 tttggtgttg cgcgggcggg aattgtggag cagtgtggag tttgtgcaaa aattgcttga
     1201 ttatcaaatt actgtggcag atattcctcc tgaatattgg cgagcattgg cacaagaggt
     1261 tgaaaatctt aaagaaactc acgaaaattc tgctcaattg aaattacgtt tgatgattgt
     1321 gggtggtgag gcgatgtccg ttgaagattt gcggcaatgg cgagaaactt ctttaaacca
     1381 tgtgaaattg ttgaatgcgt atgggcccac ggaagcaacc attgaggcga ctgtttttga
     1441 tattccaagc gattatcacc tcaacccgca tcttacgaaa atttctatcg gtaagccatt
     1501 ggcaagtcgc agaatttata ttttggataa gcaaaatcaa attgttccga cgggagtggc
     1561 aggtgagctg gttatcgcag gatgtctagc tgaaggctat ctaaacaatc caaaactgac
     1621 tgctgaaaag ttcattgaat gtgaatttaa cttggctgga cataaaatcg tcgagaaagt
     1681 ttataaaacc ggtgatctgg ctcgctatct cgctgatggt aatattgaat ttttgggacg
     1741 gattgataat caagttaaat tacgcggttt tcggattgaa ttgggagaga tcgaaaccgc
     1801 gttgaatcaa catgcccaag ttcaggaaag tattgtgatc ttgcgtgaag atcagcctag
     1861 aatcaaatat ttagctggat atattcgctt aaaaactgtt ttggtggata caagcgaaat
     1921 tgaggctgaa ttacgcgatt ttatgaaaca acaattgccg gagtacatgg tacctacagc
     1981 gtttgtgttt ttagataact ttccgttgac cggttctgga aagattgatc ggcgtgcgtt
     2041 gccagttcct aacttacaga aattcaacaa aaatatagtt accgcgcgta cttcattgga
     2101 acagcatttg gttactttat gggcagaagt gctgaaactg cctcaagttg ggatttttga
     2161 caactttttt gatttaggcg gtcacagttt atctgctaat caagtggtgt ctaaaattca
     2221 caaaactctg gctaagaaat tgatgttaaa agaatttttt acacatccga ccgtggcaga
     2281 aattgcagaa ttgctggaaa aacgcggacg ttccgatttg ccgccaattc aaccgattgc
     2341 gtcacaaccg cattatccct tgtcgtatgc acaacggcgg ttatggactg caactcaaat
     2401 gactggagat tcagcggctt acaatatggt cggcggtttt atcttgagtg gcaatttaaa
     2461 tgtcgcagcg ttcaaacagt gctttaactc attgattgca cggcatgaat cgttacggac
     2521 tcggtttatt acggtggcgg gcgaaccacg tcaggaaatt ttgccaactt tagcttttga
     2581 agtgattgaa gccgatatca gtcatcaagc tgaagaagct gctcaaagcc tgttttatca
     2641 agaattgcaa gcaacttttg atctgcgtca agttccgctg ctacgggtaa aattgctgaa
     2701 attaccgtca gatagcacac cacgtcattt gtgtattgtc aacatgcacc atatcatcgg
     2761 agacggtgtt tcggttgaag ttttatttaa agaaatcatt cagttgtatc gagatttaac
     2821 tgaaaatcgc cccaattcgc tgcaaccgct cagagtgcat tataaagatt atgttttctg
     2881 gcagggcgca atgctggaaa gtgaggaagg acagcaacat cgcaattatt ggttacaaca
     2941 gttttctgat gagattccag tgctggattt gccaacagat ttcccacgtc cagcggtgca
     3001 aacacaacat ggcgaaatgc ttaagttttt catcaatgca gaattaactc gctcgttgta
     3061 tgaattaaat aaacaacaga gcgtgagctt gttcatgatg gtggttagcc tagtcaacac
     3121 gatgttatat ctttatacgc agcaagaaga tattgtgatc ggctcacctg ttgccggaca
     3181 taatcatccg gatttggaac agcaaattgg cttttatgtc aatacgttag ccttgcgtac
     3241 tcgattcagc ggttcagata attttgttga tttattggca aaagtgaagc aagtggcaac
     3301 agatgcctat gtgcaccaag attacccgtt tgacaaattg gtggaagagt tgaatttaca
     3361 acgagatttg agtcgcaccc cgttgtttga tgtgatggtc attttgcaaa attatgagcc
     3421 ggtgagcttt gatttaccaa acatcgcggt acaaagtttt atggatgatg cttctgtcac
     3481 cagtaaattt gatttgaacc tgatgtttga acaaattgac gatcaattgg gtgtgtgggt
     3541 ggaatataac accgatttgt ttaagcgaac aacgatggag cagtttgctg agaatttcat
     3601 caaattggtt caatcagtga ctaagaaccc tgttcaagaa ttaaattatt tcaaaacgtt
     3661 gttcgttgca attcatgaac aacaagaaca gtctcagttt ttacaagcga ttgatgaaat
     3721 cagtgatgat ttttagatta ttttttaatt ttatcaagga gatataatgt ctaaattacc
     3781 tgttgttaat tctcataatg aatgggatac attggaagaa gtcgttgtcg gcgtgattga
     3841 tggggcgacg gtgccgagtt ggcatattat gttgcaggct accatgccaa ctacacaatg
     3901 ggattttttt aagcagttcg ggggacagcc gtttccgaaa gagcgaattg atgccgcgcg
     3961 tcaggatttg gaggaatgcg tgcatattct ggaacaggag ggggtgaaag taactcgtcc
     4021 agatagagtt gattttacga aaccttttag cactccagaa tggcaaagtg ctggtggttt
     4081 gtatgccgct atgccgcgcg atttgttaat tgtttttggt gacgaaatca ttgaatctcc
     4141 gttgtcatgg cgatctcggc atcatgaaat tggggcgtat cggcggttga tgaaagatta
     4201 ttttcgacaa ggtggaaaat ggacgtgcgc gcctaccccg cagttgctag atgatttata
     4261 tgatgctgat tatattgaac cagaagaagg tgagccacac cgttatgtga tcacagaatt
     4321 tgagccagtg tttgatgcgg cggattttat gcgttgtgga cgggatattt ttgtgcaatt
     4381 aagccatacc acgaatcaat ttggggttga ttggctacaa cgtcatttag gtgaggggta
     4441 tcgcattcat cagattgaaa ttaaagaaca atctccgatg cacatcgacg caactttcgt
     4501 gccgcttgca ccgggtaaat tgttagtgaa tccggaaaaa ttggcgaaag tgcctgaaat
     4561 ntttaaacat tgggatgtat tttatgcccc gccaccgtgt acgcctgttg agcatccaat
     4621 gtacatgagc agtcgctggt tgagcatgaa tgtgttgagt ttggacgaaa aacgcgtgat
     4681 gatcgaaaaa ggggaagaaa cgttgattcg tgatttgaaa aaatggggat ttgagccgat
     4741 tccgtgtagt ttccgcaatt tttactcgtt cggtggcagt tttcattgtg cgacgttgga
     4801 tgtgagacga cgcggaacgt tgcaatctta tttttgaatt cgttgatata attgattttt
     4861 tagtcgattt tgctttaaaa taagtctgtt gagttgcaca aaacagtttg tattgtgttg
     4921 ggaaaatcag ggttgtgttg ttaaaattca tcccagggtg agcgtattta ccacgttttc
     4981 tgggatggat agttgggggt aggatgagtt aagctgtttt taattaattc aacgagttat
     5041 gctgtatttt gatttgctaa attaaacatc cacttttggc gcggtgcgta gccgaattcc
     5101 taattctttc aattgaaatt cgctggcagc agaaggcgca gaggttaagg ggcaacttgc
     5161 ggtttgagtt ttagggaaag caatcacttc acgaatggaa tttgcgccgg tcatcaacat
     5221 caccaaacga tccaaaccaa acgcaatgcc tccgtgtggc ggacaaccat atttcagcgc
     5281 atccagcaaa aagccaaatt tttcacgagc ttccgcttca ccaatgccca gcatccgaaa
     5341 tacggtcgat tgcatgtctg gatgatgaat ccgtatcgaa ccgccgccaa tttctgaacc
     5401 attcaaaacc atgtcataag cacgagataa tgacgcaccg ggattttgtt ccaaaactgt
     5461 caaatcggca atattgggcg cagtgaatgg atgatgcaac gcaacccagc gtttttcttt
     5521 gtcatcccag tcaaacattg gaaaatcaat cacccacaat ggtttccaac ccggcgtagt
     5581 caatttcatc tcttcgccaa tttttaagcg taacgcgccc aacgcttcat tcaccacttt
     5641 tgctttatcc gcgccaaaga aaatcacatc tccatcaacc gcttgcactc gtgccaagat
     5701 cgcagtcacc acgtcatcgg gcaaaaattt taaaatggga gattgtaaac cttccttgcc
     5761 tttttgcaga tcattaacct tgatatatgc caaacctttc gcaccataaa ttgcaacaaa
     5821 ggctgtataa tcatcaattt gcttgcgcga caattcttta ccattgggca cccgcaacgc
     5881 ggcaactcgt ccttcggggt ctttcgccgg tgctgcaaat actttaaatt caacgctgtc
     5941 taataaatct gcaatatcaa ccagttccag cggattgcgt agatcaggtt tgtcgctgcc
     6001 ataatgctgc attgcttcgg cataggtcat acagggaaaa ggttctggca aatcaaccgc
     6061 taacgtcgtt ttgaacaagt gccgaatcat cgcttccatc aagtcacgca actgaatttc
     6121 atcgatgaat gacatttcaa tatctagctg agtgaattcg ggctgacggt cggcgcgcaa
     6181 atcttcatca cgaaaacagc ggacaatttg atagtaacga tccatccctg acatcattaa
     6241 caattgttta aataattgtg gtgattgggg tagggcgaaa aattcacccg gatgggtgcg
     6301 actgggcacc aaatagtccc gggctccttc tggcgttgcc ttggtcaaca tcggtgtttc
     6361 aatttctaaa aagttttgat tatctaagaa atttcgcacg atttgattga cttttgcccg
     6421 taatttgaag cgttcttgca tttggggacg acgcagatca atgtagcgat accgtaaccg
     6481 agtttcttca ctggtattat cgtcatctaa ttgaaatggc ggcgtttctg aagtattcaa
     6541 aatggtgaca gtttgcacag caacttcaat ttgtccggtg ctaagatttt gattcatcgt
     6601 accttctgga cgataacgta ctgttccagt cacttgcaac acatattcgt tgcgaattcg
     6661 ttctgcggtg ccaaaggctt cagcaagggt aggatcaaat accacttgta ccaagccttc
     6721 tcggtcacgc aaatcgacga agataactcc accgtgatcg cgccgccgat gcacccagcc
     6781 gcataaagtg actgtttttt cgatagatgt ttcgttgaga tgtccacaat agtggctacg
     6841 catgaatttt ccttatcctg taaaaaaaga gattggctga gaggattaca tcgtggaaaa
     6901 tagttgtgaa atcatctcga taccaatctc aatctgtatt tttaactaag aggtggttgc
     6961 agcaggacac gccgggcagg tttcggtatt gccgccacat ggatttgatt ttttatcttt
     7021 aaaatccgtt gcataccaac cggagccttt gagatgaaaa ccaccaactg ctgacaacac
     7081 ttttcggagt gcggcttgat gacattgggg acattcggtt aatgggtctt cactcatttt
     7141 ttgccacgct tctaatttgt gaccacagct attacattca tattcataag tgggcataca
     7201 aaaatctcct cgaactttgg gaacttaaca ctcaaggtaa tgggggggac ttgatgaaaa
     7261 tcaaggggac tggtcacgat cagtgatatg atgaacgcag aaactcaaca cggtgagccg
     7321 tggaaaattg gtgatcaact gagtgagttg gctgagtccg agtaatttca cacaatcaat
     7381 aggttagcaa tatttagttt ttggcaattt ttggagaata aaactcaaca tctactcgcc
     7441 ctatttccat ttctggatgg tataacattt tgatattttg ggtataagca tatatcaacc
     7501 gggctacggt ttgcgcccgc aatttggagg tttgaggcga tgtggtatta ctttcagagg
     7561 gtgccggtcc caccaagata acaacccggt gtgaagggct aatatgggat tcttgtaatg
     7621 cagtttctaa cttaatttgt tcgctaggta caaattgcgt tgaaatggat tcaaattgta
     7681 atgaagtccg ttgaaatgcc gcgatccctt tcgattgctt aaccgattga atgggttgca
     7741 gtactgaagt tttcggtttt gccgcggagg gttgtgtgac gggcatagga gcggcgggtt
     7801 gctgtatcgg gttttgtgtt acaatggcga ccggacgttt gggagcggca taaccggctt
     7861 gaacattact gattagcggc gttttttcca aagtaggttt ccccacctcc aagtaactca
     7921 aaaaccaagt gaaaaccgcc atattcacca gaaataaaac tgataacaat atcgctttga
     7981 agagtgcttg taacatgttg ttttagaaag tatagtcggg gcgaaaaagg gttaaacgca
     8041 tggcgtgaca cggttgtatg ttcttacgca actcacagtg tcgattatat cacaatgatg
     8101 cactgttcga cgggagtgag caatttgttg ttttgaaata aaacagtggg ctgaaccatc
     8161 gccaaagggc aattgtgata tttttctaaa gaaatcaaat gattatctgc aaagtttccc
     8221 aataaaaacg acgtgacgaa aactaacgtt gttgagttac tcaaaaatga gagaaagata
     8281 tgacctatgt tgtcacagat aattgtattc gttgtaaatt ttcagattgt gttgatgtgt
     8341 gtccagtgga ttgtttccat gaaggaccca attttttggt gattgatcct gaagaatgta
     8401 ttgattgtac tttgtgcgtc gcggagtgcc cggcaaatgc gattatgccc gcagacgatg
     8461 tgccagaatc aatgcaacat tttattgaat tgaacgctga attatccaag atttggcccg
     8521 tcattttgga gaaaaagcaa ccattacttg acgctgaaca gtggaatggc agaacagata
     8581 agctgcaatt tttggagcgt taattttctt aattcaacac agaaccgatt tgatgatggt
     8641 cgaaacttcg tcatgtagcc caccaaaaat ttcacgatat gaaatggtgg gcaaaattaa
     8701 atattgtact gttacatttc cgttgaacat ggttgaacat tgctgatctt ccgaatttcc
     8761 ttgagaatac attatttttc agacaattaa caaaaattaa tgaggttgac aactatcact
     8821 aaatacttta atattcactg atatactcta ataaatgcga ttatgtcaac taaattccat
     8881 cctagcagag aagcagcacg tattttaggt gttcatccaa actctttaag aaaatgggcg
     8941 gacattggtg aaattaacta catcaaaacc aaatcaggtc aacgacgtta tgatgtcgat
     9001 agttacattg gaaaatcaac cacttccatc acaatctgct actgtcgagt ctcaagccac
     9061 aagcaacgag acgatcttga acgacaagtc gaattcttgc aaaatcaata tcctacagca
     9121 gaattcgtca aagacatcgg aagtggactc aatttcaaac gaaaaggtct taaaaccatt
     9181 ttagaacgag caatgtcggg aactcacatc acacttgtgg ttgcccatcg agatagactt
     9241 gcgagatttg ggattgatct cattcgacaa gtcattgagc aaaatggtgg aaaactcgtg
     9301 gttctcaatg aaactttact ctcgttagaa caagaactta ccaacgactt gctcaatatc
     9361 gtccgcgtat tttctgcaag aatgcccgga cttagaagtt ataaaaagca aatcaatcaa
     9421 attgtcactg actctaaaac agaataggac atttaaacac tggcacaatg tgagcagatg
     9481 ggtttttaat caagtactta atttcatgat tgttcatgaa atgaatgaag aattgggctg
     9541 aaaaaacctt catggatgga cattaaaaag atgttcaccc aaactttgcc cgaatggacg
     9601 aaagatgttc cgtttcaaat caccagtaaa acccatccag aaacggatga agtaaaaaaa
     9661 gtcggttcag taaaacgcat taagttgttg aatagaaagt ggatcaatcg tggcatcgta
     9721 ggcgcatgta atgttttgtt acgtgccttg gtagatcaac cccacaaagt aacgtggcag
     9781 ttagcagatg tgaataaaat taactgttgt taagaaaaaa tgatcggatg aatatgccca
     9841 gtaagacaat taagaacagt aacgaccgtg ttgatagttc cgaacaaacg accctcagat
     9901 tgtctgatga tattggcaaa atggcggatc gcatcggagg aatggcagat cgtattgggg
     9961 aaatggcgga acgaatttta aaaactcaag aaattcaagc caaaaacatc gaactgaccc
    10021 aaaagtcgat gttggaattg atgcaagcga tgactaaaca aatggaattt agtaatcggt
    10081 tgatggagtt gatgtttgac aaaggtgaca atgtgccggg taaacagtta ccctcatggc
    10141 agttatccaa atcgacagaa cccgcaaaaa aatccgaata gtttagtcaa gtggttgcgt
    10201 tggtggcacg aattgtagtg cctatcattt acaggacgga gcactcaaaa tcaggctgac
    10261 ttcctgataa ttttgccaac tgtctcgcac tttcttgttg gatcagcaca gtaagagctt
    10321 gatttccctt ttttattcga tttaaataaa tttgacaggt caattctacc atacacctct
    10381 gacattaaaa cgacaaaggt gcatgataat tcagatttta aagtccaagt ggcaagtctt
    10441 ttttcgagaa aagctgttgt ttttgttccg gcgttaattt ttcaaaaaag ggattttccg
    10501 ccaatcgttg ccttgcttgt tccacagaaa ttgcatcttt ttcgctaaaa agccacacat
    10561 tgaaattatc ccatgtccgc catacacttg cagcgataat taataacgat attggaatta
    10621 tcgcaagcaa tagcagtggc aaaaataaga aaaatgagat attatgttgg aaaatgactt
    10681 ttt
//
