LOCUS       c00211_3300002..       12234 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300002858.a:JGI1201J43222_100322.
ACCESSION   c00211_3300002..
VERSION     c00211_3300002..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 04:47:05
            Original ID  :: 3300002858.a:JGI1201J43222_100322
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12234
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12234
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[214:9487]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      215..9487
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     protocluster    1..12234
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[214:3174]"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      215..3174
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="2"
     cand_cluster    1..12234
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="chemical_hybrid"
                     /product="NRPS"
                     /product="betalactone"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12234
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             3..239
                     /locus_tag="ctg211_1"
                     /transl_table=11
                     /translation="EIEPLIQSVGAXVLYQSPYSPDFNPIEHWWSQLKAFLRQFSPTNS
                     KMVDVLIRTALDLVNPKHLKNWFTSCCYCTSLT"
     CDS             215..2011
                     /NRPS_PKS="Domain: PCP (504-573). E-value: 5.7e-16. Score:
                     50.3. Matches aSDomain: nrpspksdomains_ctg211_2_PCP.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     120.4; E-value: 1.2e-36)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg211_2"
                     /sec_met_domain="AMP-binding (E-value: 8.5e-44, bitscore:
                     139.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-14, bitscore:
                     44.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PF00881 (E-value: 4.7e-16, bitscore: 49.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LLLYLTYLKSAVSLGGATEASIWSIYYPIDKVNPNWKSIPYGKPL
                     SNQQFYVLNELMEPTPVWVVGELYIGGIGLALGYWGDESKTNARFITHPVTGERLYKTG
                     DLGKYLPSGNIEFLGRSDFQVKINGYRIELGEIEATLKQHPIIKQAVVTAVGESQNKQQ
                     LVAYVVSDNPSTQNPTEAYQPTQQEGVLQDPGERIEFKLKQPGLRQIEPSEHSIQLPRT
                     EFDEDLTQAYLKRQSYRKFLQKPISLTEFSQFLSCLQQMKLEDYPLPKYLYPSAGSLYP
                     VQTYLLIKPNGVEGLQAGIYYYHPREHRLILVRGRSEIDNNILDNSIFDSSIYRGNQPI
                     FDNGAFSLFLIGELNAITPIYGELAKDFCLLEAGNIGQLLMQSAPDQEIGLCPIGYLEL
                     NEIKDLFKLKYSQILLYSFVGGKIDLAQTKQWLNSKKDKDSQSISVQLRKYLQQKLPVY
                     MVPFEYISLDALPLTANGKVDRKKLPSPNILNFQPDSVLTPPRTEMEITLAEMVQQILQ
                     IDAVGIDNNFFQLGMDSLNLVQLKNKLQTQIGVNVSMKQLLVEATNIAELAIAVDEQLT
                     LKKIKSSTLSTESNDDTEIIEL"
     CDS_motif       395..484
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg211_2_0001"
                     /evalue="1.10E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg211_2"
                     /protein_end="90"
                     /protein_start="60"
                     /score="46.4"
                     /tool="antismash"
                     /translation="PVWVVGELYIGGIGLALGYWGDESKTNARFI"
     CDS_motif       563..628
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg211_2_0002"
                     /evalue="2.90E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg211_2"
                     /protein_end="138"
                     /protein_start="116"
                     /score="38.4"
                     /tool="antismash"
                     /translation="FLGRSDFQVKINGYRIELGEIEA"
     aSDomain        1727..1933
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg211_2_PCP.1"
                     /evalue="5.70E-16"
                     /label="ctg211_2_PCP.1"
                     /locus_tag="ctg211_2"
                     /protein_end="573"
                     /protein_start="504"
                     /score="50.3"
                     /tool="antismash"
                     /translation="EITLAEMVQQILQIDAVGIDNNFFQLGMDSLNLVQLKNKLQTQIG
                     VNVSMKQLLVEATNIAELAIAVDEQ"
     aSModule        1727..1933
                     /domains="nrpspksdomains_ctg211_2_PCP.1"
                     /incomplete
                     /locus_tags="ctg211_2"
                     /tool="antismash"
                     /type="unknown"
     CDS             2008..3174
                     /NRPS_PKS="Domain: Heterocyclization (72-364). E-value:
                     4.3e-110. Score: 359.5. Matches aSDomain:
                     nrpspksdomains_ctg211_3_Heterocyclization.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     116.4; E-value: 3.2e-35)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg211_3"
                     /sec_met_domain="Condensation (E-value: 7e-55, bitscore:
                     175.9, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRNELLKELDRQGIKLSTRKEKLIIEAPKGALTPELKNSLAEHK
                     QDIIRLLGQTEINTTSLPVIEPEFTRRYEPFPLTDIQQAYWIGRSGIFDLGDVAINGYI
                     EFESENLDLSRLSAAWRKLVDRHDMLRAIVLPTGEQQILEKVPSYEISTLDLRGVEHLE
                     AERILATMREELSHQMLPCDQWPLFDIRATYLSDRRIRLHFKIDLLMMDAASVQILFQE
                     WNQLYQNPELSLKPLEVSFRDYVINKQTRQDPELVRRSQNYWFNRLDDLPPAPELPLVY
                     FPSDLKDYRFKRYRARIEPNIWEQLKQKGKNVGFTPSAILLTAFAEILKLWSKNPRFTI
                     NLTVFERLPLHPEIDRILGDFTQYLRQKKSMKRKRIDVVKLLSSTTTT"
     aSDomain        2224..3099
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg211_3_Heterocyclization.1"
                     /evalue="4.30E-110"
                     /label="ctg211_3_Heterocyclization.1"
                     /locus_tag="ctg211_3"
                     /protein_end="364"
                     /protein_start="72"
                     /score="359.5"
                     /tool="antismash"
                     /translation="YEPFPLTDIQQAYWIGRSGIFDLGDVAINGYIEFESENLDLSRLS
                     AAWRKLVDRHDMLRAIVLPTGEQQILEKVPSYEISTLDLRGVEHLEAERILATMREELS
                     HQMLPCDQWPLFDIRATYLSDRRIRLHFKIDLLMMDAASVQILFQEWNQLYQNPELSLK
                     PLEVSFRDYVINKQTRQDPELVRRSQNYWFNRLDDLPPAPELPLVYFPSDLKDYRFKRY
                     RARIEPNIWEQLKQKGKNVGFTPSAILLTAFAEILKLWSKNPRFTINLTVFERLPLHPE
                     IDRILGDFTQYL"
     aSModule        2224..3099
                     /domains="nrpspksdomains_ctg211_3_Heterocyclization.1"
                     /incomplete
                     /locus_tags="ctg211_3"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2245..2274
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg211_3_0001"
                     /evalue="5.20E-04"
                     /label="Cy1"
                     /locus_tag="ctg211_3"
                     /protein_end="89"
                     /protein_start="79"
                     /score="12.4"
                     /tool="antismash"
                     /translation="DIQQAYWIGRS"
     CDS_motif       2335..2403
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg211_3_0002"
                     /evalue="5.70E-10"
                     /label="C2_DCL_024-062"
                     /locus_tag="ctg211_3"
                     /protein_end="132"
                     /protein_start="109"
                     /score="31.5"
                     /tool="antismash"
                     /translation="NLDLSRLSAAWRKLVDRHDMLRAI"
     CDS_motif       2608..2652
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg211_3_0003"
                     /evalue="7.70E-06"
                     /label="Cy3"
                     /locus_tag="ctg211_3"
                     /protein_end="215"
                     /protein_start="200"
                     /score="19.0"
                     /tool="antismash"
                     /translation="RLHFKIDLLMMDAASV"
     CDS_motif       2947..3006
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg211_3_0004"
                     /evalue="8.90E-08"
                     /label="Cy4"
                     /locus_tag="ctg211_3"
                     /protein_end="333"
                     /protein_start="313"
                     /score="24.9"
                     /tool="antismash"
                     /translation="GFTPSAILLTAFAEILKLWSK"
     CDS_motif       3019..3057
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg211_3_0005"
                     /evalue="1.00E-04"
                     /label="afterCy4"
                     /locus_tag="ctg211_3"
                     /protein_end="350"
                     /protein_start="337"
                     /score="14.8"
                     /tool="antismash"
                     /translation="FTINLTVFERLPLH"
     CDS_motif       3058..3093
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg211_3_0006"
                     /evalue="1.50E-05"
                     /label="Cy5"
                     /locus_tag="ctg211_3"
                     /protein_end="362"
                     /protein_start="350"
                     /score="17.4"
                     /tool="antismash"
                     /translation="HPEIDRILGDFTQ"
     CDS             complement(3259..4119)
                     /gene_functions="other (smcogs) SMCOG1245:ABC transporter
                     protein, integral membrane (Score: 301.9; E-value:
                     6.5e-92)"
                     /gene_kind="other"
                     /locus_tag="ctg211_4"
                     /transl_table=11
                     /translation="MGIETVWQWFVAPLQFEFMIKAIFVSALVGVVCSMLSCYMTLKGW
                     ALMGDAVSHAVLPGVVIAYIVNIPFAIGAFIFGLGSVVSIGFIKSKTRIKEDTVMGLVF
                     TGFFAFGLVLISKTPSNIDLMHILFGNVLGISDQNLIQTIIIGVITIISLTVLRKDLLL
                     FCFDATHARSIGLNTTALYYILLSLLALTIVAAQQTVGIILVIAMLVTPGATAYMLSDS
                     FGTMTIIAVASGVFSSLMGTYISYHLDASTGGCIVVLQTLLFVAAMIFAPKHGMLVRHL
                     QARGR"
     CDS             complement(4419..5165)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 173.1; E-value:
                     1.3e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg211_5"
                     /transl_table=11
                     /translation="MSRIAVQVEEVTVTYNGKVALHGANLELKTSSISGLVGMNGSGKS
                     TLFKSIMGFVKPITGRVLIKGMSISKAQKQNLVAYIPQTEDVDWNFPIGVKDVVMMGRY
                     GYMNFLRIPSANDRRVVQESLKRTHMEEFSDRQIGELSGGQKKRAFLARALAQQAQIIL
                     LDEPFTGVDIKTEKAIIQLLVELRNMGHTILISTHDLSSISTFCDDVVLINRTILAYGP
                     TGEIFTEENIARTFGGMVPVGGIGNK"
     CDS             complement(5315..6292)
                     /gene_functions="transport (smcogs) SMCOG1252:cation ABC
                     transporter, periplasmic (Score: 297.6; E-value: 1.5e-90)"
                     /gene_kind="transport"
                     /locus_tag="ctg211_6"
                     /transl_table=11
                     /translation="MINIFRRQPQVSKLVIAVGIVFGLLVSGCNNSNNVSFDQGQESSN
                     TGQSPDAKNRKIILTTFTVLADMARNVAGDKATVQSLTRPGAEIHGYEPTPSDIVKAQK
                     ADLILDNGLGLERWAQKFYGNLRDVPHATLSEGITPINISEDAYAGKPNPHAWMSPKLA
                     LRYVDNIRASLVKLDPANAETYNANAKAYSQQIKQVDLKLQETVEKIPQNRRFMVTCEG
                     AFSYLANDYGLKEVYLWAVNSEQQATPRQVEKVITTVRKNQIPVVFCESTVSADAQKQV
                     AKESNSKFGGVFYVDSLTEENGVAPTYFKLLEYNINTLVNGLKK"
     CDS             complement(6804..7361)
                     /locus_tag="ctg211_7"
                     /transl_table=11
                     /translation="MAKQNLRLSEFELEGKFLGFFRNKSGKLKYLRLMITAGDVKIKLP
                     KKLRNAASLYLVPGEEISIRGISKRKINKNHSKVKLKAKFIKSANFFPKQHIEEHSKAK
                     ILICQKPRCIKSGGKDLVSKLEKTLCQQGLQDQVIIKRSGCLKRCSKAPNCVLEMSAKK
                     SSNNQPVHPKKIISLLEKYVSS"
     CDS             complement(7713..7916)
                     /locus_tag="ctg211_8"
                     /transl_table=11
                     /translation="MKVMLRENSEGTLIVYVAKKDLEEEVVKQTDGSEGKIFTLANGWE
                     LVFPDLPDPLQLPKTVEARRLA"
     CDS             complement(7999..8280)
                     /locus_tag="ctg211_9"
                     /transl_table=11
                     /translation="MQLDELELHLPPVFDIGDKVRIRKLIKNDGTFPGKQVGEVLANIG
                     DVGYIVSIGTYLQTAYIYAVHFLDKGYVVGCRKRELEAVETNPENDEQ"
     CDS             complement(8267..9487)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 358.5;
                     E-value: 1e-108)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg211_10"
                     /sec_met_domain="HMGL-like (E-value: 2.4e-79, bitscore:
                     256.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPTISNCLKLGPKSIKRLGNFPTIGTIKMNQVLINDTTLRDGEQ
                     AAGVAFNLEEKIAIAKFLDAIGLEEIEVGIPAMGEEEQRAIQSIADLGLSAKLLGWNRA
                     VISDIKASMACGLKRMHIAIPVSGIQIATKFQGQWRITLQQLKDCISFAVDKGFWVAVG
                     GEDSSRADDEFLLDVALYAQEWGAKRFRFCDTVGVLDPFTTYSKVKRLVSGLRIPVEVH
                     THNDFGLATANALAGLKAGALSVNTTVNGLGERAGNAALEEVVMAIKRMYGVDLGIDTP
                     RLLELSKLVANASGCRVPPWKAIVGENTFAHESGIHAHGVLKNPFTYEPFAPEEVGRER
                     RLVVGKHSGRHLISNLLKQHGIFLSKEETQSVLDAVRQCSMEKKRNLTTEELLDLVKIQ
                     KYSHAIR"
     CDS             complement(9537..9737)
                     /locus_tag="ctg211_11"
                     /transl_table=11
                     /translation="MMFNYRRDRKFIVFLQNELELSNSDIAVALRHRECDSARLPMLLW
                     QYGLIDLEQLERIFDWLEKQV"
     CDS             complement(10403..10651)
                     /locus_tag="ctg211_12"
                     /transl_table=11
                     /translation="MSHYDSPKTITVRLCLELPVGTRWQIYHRLQELKIECSCSDDGSL
                     RIKVNQFEDLVLLQSTLKQFTASRQELIDWLDKCWNL"
     CDS             complement(10621..11541)
                     /locus_tag="ctg211_13"
                     /transl_table=11
                     /translation="MQKSDYRLDKFLIETISDEPVLNCAIEDMDKAEKLGKKISFEPIW
                     SDFRIIFERDPAAHNWLEVLFCYPGLHALWLHRIAHWLYECQISFFPRLISHIARFLTG
                     IEIHPGAKIGKGVFIDHGMGVVIGETAIIGEYSLIYQGVTLGGTGKESGKRHPTLGKQT
                     IIGAGAKILGNIHIGDRVRVGASSVVLRNVPSDSTVVGVPGRNISRTQNSPLYPLEHGK
                     LPDLEGKAIISLLERVERAEKQLQSLTLQFQEQELKEQIQQKKSQAKEFKNENSRMKVS
                     KTRTHKPELVTKEPPKCHITTAQKL"
ORIGIN
        1 tagaaattga accattgatt caatccgttg gtgcaagngt tctttaccaa tcaccctatt
       61 ctcctgattt taatccaata gaacattggt ggtcacaact caaagctttt ctacgtcagt
      121 tttctccaac caattcgaaa atggttgatg ttctgattag aactgccctc gatttagtca
      181 atcccaagca tttaaaaaac tggttcacaa gctgttgtta ctgtacctca cttacctgaa
      241 aagtgctgta agtttggggg gagcaacaga agcttccatc tggtcgattt actatccaat
      301 tgacaaagta aatccaaatt ggaaaagtat tccttacggt aaacctttaa gcaaccaaca
      361 gttttatgta ttgaatgaat taatggaacc gactccggta tgggttgtgg gagaacttta
      421 tattggtggg attggattag cgttaggtta ttggggagat gaatcaaaaa caaatgctag
      481 gtttatcact catccggtca caggggaaag attatacaaa actggggatc taggaaaata
      541 tttaccttca gggaatattg agtttttggg aagatcggat tttcaggtaa aaatcaatgg
      601 ttatcggatc gaattaggag aaattgaagc gacattaaaa caacatccca taattaagca
      661 agctgtggtt actgcggtgg gagaatcaca aaataaacaa cagcttgtag cttatgttgt
      721 tagtgataat ccctcaactc aaaatcctac agaagcttac caaccgactc aacaagaagg
      781 agtattgcaa gatcctggag aacggattga atttaagctt aagcaaccag gattgcgaca
      841 gatagaacct tctgagcaca gcattcaatt acccagaact gaatttgatg aagatctcac
      901 ccaagcttac ctgaaacgtc aaagctaccg gaaattttta caaaaaccta tttctttgac
      961 agaatttagt cagtttttaa gttgcttaca gcagatgaaa ttggaggatt atcctctacc
     1021 aaaatatctt tatccttctg ctggtagtct ctaccccgtg caaacttatt tgctaattaa
     1081 acccaatgga gtagaaggtc tccaagcagg gatatactac tatcatcctc gggaacatcg
     1141 tttgatatta gttcgcggtc gcagcgaaat tgataataat attcttgata atagtatttt
     1201 tgatagcagt atctatcgtg gcaatcaacc aatttttgat aatggtgctt tttcactatt
     1261 tttgattggc gaactaaatg ctattacccc aatttatgga gaattagcaa aagacttttg
     1321 tttgttagaa gcaggtaaca tcggtcaatt attaatgcaa tctgcaccgg accaggaaat
     1381 aggtttatgt cccattggct atctggaatt aaacgaaata aaagatttat ttaagctcaa
     1441 atatagtcag attttgcttt atagttttgt gggtggcaaa attgatttag ctcaaaccaa
     1501 acagtggttg aactctaaaa aagacaaaga ttcccaatct atttctgtac agttaaggaa
     1561 atatttacaa cagaagttac cagtatatat ggtgcctttt gaatatattt cattagatgc
     1621 tttaccccta actgcaaatg ggaaagtaga ccgcaagaag ttacctagcc ctaatatact
     1681 taattttcaa cctgattcag tcttaacacc tccaagaact gagatggaga taactttagc
     1741 tgaaatggtg caacaaattc tgcagataga tgctgtgggt atcgataata atttcttcca
     1801 gttggggatg gattcattaa atttagtaca gttgaaaaat aagttacaaa ctcaaattgg
     1861 ggtaaatgtg tctatgaagc aattgttagt agaagctact aatatcgcag aattagctat
     1921 agccgtagat gaacaattga cattaaaaaa aattaaatca tcaaccttat ctactgaatc
     1981 taatgatgat acagaaataa tagaattatg aatagaaatg aacttttaaa agaactcgac
     2041 cgacagggaa taaagttatc aaccagaaaa gagaaattaa ttattgaagc tccaaaagga
     2101 gcattaaccc cagagttaaa aaactcctta gcagagcata agcaagatat tatacgtttg
     2161 ctcggtcaaa ccgagattaa tactacttct ttaccagtaa ttgaaccaga gtttaccaga
     2221 cgttacgaac cttttccgct gactgatatt cagcaagcat attggattgg aaggagtggg
     2281 atctttgatt taggggatgt agctattaat ggttatatcg agtttgaatc ggaaaattta
     2341 gacttatcac ggctttctgc agcttggcga aaattagtcg atcgccacga tatgctacga
     2401 gcaatagtcc tacctactgg ggagcaacag attttagaga aagttcccag ttatgaaatt
     2461 tctactctgg atttgcgagg agtagaacat ttggaagcag aaaggatact cgcaaccatg
     2521 cgagaagaat tatcccatca aatgttaccc tgcgatcaat ggcctttatt tgatatccga
     2581 gccacttatt taagcgatcg tcggatacgg cttcatttca aaattgattt attgatgatg
     2641 gatgctgcta gcgttcaaat tttatttcag gagtggaatc aactttatca gaatcccgaa
     2701 ctttctttga aaccattaga ggtatcattc cgggactatg taattaacaa gcaaacacga
     2761 caagatccag aattggtcag gcgatcgcaa aattactggt tcaatcgttt ggatgattta
     2821 cctccagcac cagaattacc tttagtctat tttcccagcg atttaaaaga ttatcgattt
     2881 aaacgttacc gtgctcgaat cgaacccaat atttgggagc aattaaaaca gaaagggaaa
     2941 aatgttggtt ttactccttc tgcgattttg ttgactgctt ttgcagaaat tttgaagctg
     3001 tggagtaaaa atcctcgttt tacaatcaat ctcaccgttt ttgaacgtct tcccctccat
     3061 cctgaaattg atcgcatttt gggagatttt actcaatacc ttcgccaaaa gaagagtatg
     3121 aagagaaaga ggattgatgt tgtaaagtta ttgtcttcca caaccacaac ttgatttcta
     3181 caaactagcc catgttcgac atactggtac taccacaatt acaatcaagc cccgttaaaa
     3241 attcagattc ataatcaatt acctgccccg tgcttgtaaa tgtctgacca acattccgtg
     3301 tttgggtgca aaaatcatcg cagcaacaaa caataaagtt tgtaatacta caatacaccc
     3361 acccgtggat gcgtcaagat ggtaactaat ataggttccc attaaactgg aaaatactcc
     3421 ggaagcaaca gcaatgattg tcatcgtacc gaaactatcg ctcaacatat aagcagttgc
     3481 tcctggggtt actaacattg caatcactaa aataattccc acagtttgtt gagctgcaac
     3541 aattgttaaa gcaagcaatg ataacaaaat atagtacaaa gcagtagtat ttaatcctat
     3601 actacgtgca tgggtcgcat caaaacaaaa tagtagtaag tctttccgta aaactgttag
     3661 agatattata gtaataacgc caattatgat tgtttgaatt agattttggt cggaaatacc
     3721 taaaacattt ccaaacagaa tatgcattaa atctatatta cttggcgtct tagaaattag
     3781 taccaaacca aaagcgaaga aaccggtaaa tactaaaccc attaccgtat cctctttaat
     3841 tcgagttttt gacttaataa atccaattga aactactgaa cccaagccaa atataaaagc
     3901 tccaatagca aaaggaatat ttacaatata agcaatcaca actcctggaa gtactgcatg
     3961 ggaaaccgca tcacccatta aagcccaacc tttgagagtc atataacatg aaagcatgga
     4021 acaaacaaca ccgactaaag cacttacaaa tattgcctta atcataaatt caaattgcaa
     4081 aggtgcaaca aaccattgcc aaactgtttc tatacccata attttgaccg gtcaaattat
     4141 tttctaaatt tgaaaaaact ccacaaaaaa ttaatataaa atattaacaa ttaattacca
     4201 catagctaac gccataatgc ataagctttt actcattact gtgcgctgtg tacacttacg
     4261 tgtcccgcta gaccgcgccg cgagcggcga atgctaacgc gcccgcaata ccttacggta
     4321 ggctaccgct agccgctaac attacttatt actcatgact cattacttat tacttgttac
     4381 ttattactca ttactaatga cttattactt attacttatt acttattacc aattccccca
     4441 accggtacca ttcccccaaa ggtacgagca atattctctt ctgtaaaaat ctctcctgta
     4501 ggaccgtaag ccaaaatagt acgatttatt aatactacgt catcacaaaa tgtcgaaata
     4561 gaagaaaggt catgggtaga aattaaaatt gtatgaccca tatttcgtaa ttcaaccaac
     4621 agttgaataa ttgccttttc tgttttaata tctactcccg taaagggttc gtctaaaaga
     4681 attatttgtg cttgttgcgc caaagcccgt gctaaaaatg ctcgtttttt ttgcccgcct
     4741 gaaagctctc caatttgtcg atcgctaaat tcttccatat gggttctttt taaactttcc
     4801 tgcacaactc tgcgatcgtt agcactggga atccttaaaa aattcatgta gccatagcgt
     4861 cccatcatga ctacatcttt cacaccaatc ggaaaattcc aatctacatc ttcagtttga
     4921 ggaatataag caaccaaatt ttgtttttgt gctttactta tcgacattcc tttgattaaa
     4981 acacgtccag ttatgggttt aacaaaaccc ataattgatt taaataaagt tgatttaccc
     5041 gagccattca tccctaccaa accacttata gaagaagttt ttaattctaa atttgctcca
     5101 tgcaaagcaa ctttaccgtt gtaagtaact gtaacttctt ctacttgaac cgcaattcta
     5161 gacataataa ttataattta tcccaatgaa agtatttatt acaactaatc ttcattaaaa
     5221 tacaaatatt tgatggaaaa atataaagat attgatgcat ctactatata gtagtatgat
     5281 gactttttaa ctcttaaaat atctcaaatt agccctattt ttttaaacca ttaactaaag
     5341 tattaatgtt atactctaat aacttaaaat aagtaggtgc aacaccattt tcttcagtaa
     5401 gtgaatcgac ataaaataca ccaccaaatt ttgaattcga ttctttagca acttgtttct
     5461 gagcatcagc acttacagta ctttcacaaa aaactacagg tatttgattt ttccttactg
     5521 ttgtaattac tttttcaact tgtctcggag ttgcttgttg ctcggaatta accgcccata
     5581 aatatacttc ttttaaacca taatcattcg ctaaataaga aaatgctcct tcacaagtca
     5641 ccataaaacg tctattttga ggaatttttt ccacagtttc ttgtaacttt aaatccactt
     5701 gcttaatttg ctgactataa gctttagcat tagcattata agtctctgca tttgccgggt
     5761 ctaactttac taaagatgca cgaatattat ctacatacct caacgctaat tttggtgaca
     5821 tccaagcatg gggatttggt tttcctgcat atgcatcttc gctgatattt attggtgtta
     5881 tcccctcact taaggttgca tgaggaacat ctcttaggtt cccataaaat ttctgtgccc
     5941 aacgttctaa acccaaacca ttatctaaaa taagatctgc tttttgagct ttaactatgt
     6001 cgctaggagt cggttcgtat ccatgaattt ccgcccctgg tcttgtcaaa gattgaacag
     6061 tagctttatc cccagcaaca ttacgagcca tatctgcaag tactgtaaag gttgtcagga
     6121 taattttcct attctttgcg tctggactct gtcccgtatt actagattct tgtccctggt
     6181 caaaggatac attgtttgaa ttattacatc cgctcaccaa taaaccaaat acaattccaa
     6241 ctgctattac cagttttgat acctggggct gtctcctaaa aatatttatc atttagctcc
     6301 cgagaactaa tctcataatc ttctcatttt tatactatag tacttggata gcaaaaatga
     6361 aagaattatg agaaagatat tagattgcaa aaatctcaga cgacagattt ttaatcggtg
     6421 gaatacagca aatacctaag ggtgataata gcggataaat taaagatacc tattttcttt
     6481 tcctcgctcc atgttatatc aaatacttgt tttaaatggt tatgtttcga atctaaagaa
     6541 aattaaaaat tcatttacat taggaagaac taccagcacc taaaaacgct aattcccgct
     6601 ggtttgctgc tggaattgga gttcacgcaa ttttgttaat aggtatttgg actatgtaaa
     6661 ataaataata gttcaggatt ttagagaaaa tagacattta attaatttta aatattaagt
     6721 agtataaaat acaagtatta tggtaaagca taaaatgttc tacctctatt tatttgactc
     6781 atatgtgttt tgctcgtagt aatttaagaa cttacatatt tttctaatag agaaataatt
     6841 ttctttggat gtactggctg gttgttacta gatttctttg cggacatttc cagaacacag
     6901 ttaggagctt tggaacaacg ctttaaacat ccgctacgtt taataattac ttggtcttga
     6961 agtccttgtt gacagagagt tttttctagc tttgatacta aatctttccc accactttta
     7021 atgcaacggg gtttttgaca aatcaaaatc ttggcttttg agtgttcttc tatatgttgc
     7081 ttcgggaaaa aattagctga cttgatgaat ttagctttca gttttacttt gctatgattt
     7141 ttattaattt tccgtttgct gatacctcta atactaatct cttcaccagg aactaaatat
     7201 aaacttgctg cattccgtaa ttttttcgga agtttaattt ttacatctcc tgctgtaatc
     7261 attaatctca aatactttaa ttttccagat ttatttctaa aaaagcctag aaatttacct
     7321 tcaagctcaa attctgatag ccttaggttt tgcttagcca tttttttctg ttctcaattc
     7381 tgcaacaata aattttagag ctataaactt gaagctatgc atttaaagcg actcatatag
     7441 aactgtaaaa ttaaaaccaa gctaaaaaat acatagtata tattaacacg catatattaa
     7501 gacacttaat gagtggagag tatagagtta agagttaggt ataggaatac aatgcctgct
     7561 tgagcgccac tcaaaagtgt tatggattgc gaccgctagt tagatggaaa gcccatagcc
     7621 tattagcact ccaaagaaca ctagatcaag aatttcttta caagcggaca caatataaca
     7681 attcataact cacaactcac aactcaaaaa aactaggcta accttctagc ctctactgtt
     7741 ttaggtaact gtaatgggtc tggtagatcg ggaaaaacta attcccaacc attagctaaa
     7801 gtaaaaattt taccttctga cccatcagtt tgtttgacaa cttcttcctc aaggtctttt
     7861 tttgccacat aaacaattag agttccttca gaattttcac gcaacattac tttcattgaa
     7921 aacctcactg ttagatttgt aatactttgt ttcagttatc acccgtcagt tatcatttaa
     7981 gcttcttata ttttctgttc attgttcgtc attctctggg ttagtctcaa cagcctctaa
     8041 ttctcttttt cgacaaccga caacataacc tttatccaaa aaatgtactg cataaatgta
     8101 ggcagtttgt aagtaagtac caatactaac gatatagcca acatctccta tgttcgctaa
     8161 aacttcacca acttgtttac cagggaaggt accatcattt ttgatcagct ttcgtatccg
     8221 gactttatct ccaatatcga atactggagg taaatgtaat tcaagttcat ctaattgcat
     8281 gggaatattt ttgtattttt accaaatcca acaactcctc ggtcgtgaga ttacgtttct
     8341 tctccatcga acactgtcga actgcatcaa gaacagattg agtttcttcc ttacttagga
     8401 aaatgccatg ttgcttcagt aaattagata ttaagtgacg acccgaatgt ttacctacga
     8461 ctaaacgacg ttcgcgacct acttcttctg gtgcaaaagg ctcataggta aatggatttt
     8521 ttaaaactcc atgagcatga attccagatt catgagcaaa ggtattttca ccaacaattg
     8581 ctttccaagg tggaactcga caaccagatg catttgcaac aagttttgat agctctaata
     8641 aacgaggggt atcaatacct aaatcaaccc catacattcg tttgattgcc attactactt
     8701 cttccaatgc tgcattacca gctctttcac ccaatccgtt aacagttgta ttaacgctta
     8761 aagctccggc tttaagtcca gcaagagcat tagctgtagc taaaccaaaa tcattgtggg
     8821 tgtgaacctc tacaggaatt cgtaagcctg atactagacg tttaacttta ctgtatgtgg
     8881 taaaagggtc gagaactcct actgtgtcac agaagcgaaa acgttttgca ccccattctt
     8941 gggcgtaaag ggctacatct aaaagaaatt catcatcagc tctggaggag tcttcaccac
     9001 caaccgcgac ccaaaagcct ttatccacag caaaactaat acagtctttg agttgctgta
     9061 atgtgatccg ccattgacct tgaaactttg tcgcaatttg aattccagat acggggatag
     9121 caatatgcat tcgcttcaga ccacaagcca tagaagcttt aatatcggaa atcacagcac
     9181 gattccaacc caaaagtttt gcagataagc ccaaatctgc aattgattgg attgcgcgtt
     9241 gttcttcctc acccatcgct gggattccaa cctctatttc ttcaagacca atagcatcaa
     9301 gaaacttggc gatcgcaatt ttttcttcta aattaaaagc aacgccagca gcctgttcac
     9361 catcgcgtaa agtggtgtca ttgattagga cttgattcat tttgatagta cctatagtgg
     9421 gaaaatttcc taatctcttt attgattttg gtcctagttt taggcaatta ctgatagtgg
     9481 gtaacatatt tgccaaaata tttatgctta aacacagatt tcacttgcag attcacttaa
     9541 acctgctttt ctaaccaatc aaaaattcgt tctaactgtt ccaaatcaat taagccatat
     9601 tgccatagca gcattggtaa acgagcactg tcacattctc gatgtcgcaa cgcaacagct
     9661 atatctgagt ttgatagttc cagttcattt tgcaaaaaaa ctatgaattt tcgatcgcga
     9721 cgatagttaa acatcatgga acgtttagtc cttatactta gaatttaatt agaaaatatg
     9781 aataaataaa tatttctcct tttatactga tgatttcgga aaatgatttt taactctgag
     9841 aacaatttca ggaaaattta atattttcac tacaaaagaa acccaagaat tggggttttt
     9901 tttagaaaaa tcagtatcga aaaatatttg tttttcagta tgcagcaaat gttacttttt
     9961 ggtgtagggg gtagtaccat tacctaaaac tcaaagaaaa ataatgagta tcaagtaatg
    10021 atttagtagc aactaaagtg agattctaat tcattacttg gacacgtatc tatttatgat
    10081 attgccaagc aatgaaaaat tctcttgaaa aaatctaaat ttagattccg gcattctgag
    10141 aaaagagcga tcgcttgatt ccaaagcatt tgtggcgcta cgcccaagtc attagcatag
    10201 ggtgacggcg cttatgaact aacttctcgg atcggcgcag ctagagcttt tatggtgtcg
    10261 gcggagccac aggtagcgca gctataagcc tctaggggag cgcaagcaca gtaaaagctt
    10321 acaaatcata gctttgcggg atttagaaat gtcttaaact gattgtgtag tcttatacat
    10381 cgaatcaaag tatattcaaa gattataagt tccagcattt atctaaccag tcaattagtt
    10441 cttgtcggga agctgtaaat tgctttagag tgctttgcag taaaactaaa tcttcaaact
    10501 gattgacttt aattcgtagg gaaccatcat cagaacaaga acattcaatt ttgagttctt
    10561 gcaatctatg ataaatttgc cagcgagttc caacgggaag ttctaagcac aagcgaacag
    10621 ttatagtttt tgggctgtcg taatgtgaca tttgggaggt tccttggtta caagttctgg
    10681 tttgtgagtt cttgtttttg aaactttcat tcttgagttt tcattcttga attcttttgc
    10741 ttgagatttt ttttgttgaa tttgttcttt aagttcttgt tcttgaaatt gcagagtgag
    10801 gctttgtagt tgcttttctg ctctttcgac acgttccaac aaggaaataa ttgcttttcc
    10861 ttctagatcg ggtagtttcc catgctctaa aggataaagg ggagagttct gagtcctgga
    10921 aatattacga ccaggaacac ctaccacagt tgaatctgaa ggaacatttc gtaatacaac
    10981 agaacttgca ccaacccgga cgcgatcacc aatatggata tttcctagaa tttttgcccc
    11041 agcaccaata attgtttgtt tacctaaggt cggatgtcgc ttaccacttt ccttacctgt
    11101 tcccccgagg gtcacacctt ggtaaattag tgaatactct ccaatgatgg cagtctctcc
    11161 aattacgact cccataccat ggtctataaa tacaccttta ccaattttgg ctccaggatg
    11221 aatttcaatt ccggtgagaa atcgagcaat atgagaaatt aaacgtggaa agaaacttat
    11281 ttgacattcg tataaccaat gggcgattct gtgtagccat aacgcatgca acccaggata
    11341 acaaaacagt acttctagcc aattatgtgc tgctggatcc cgttcgaaga taatacgaaa
    11401 atcactccaa attggttcaa aactaatttt cttacccagt ttctcagctt tatccatatc
    11461 ctcaattgca caattcagca caggctcgtc tgagattgtc tcaattagga acttgtcgag
    11521 ccggtagtcg gatttttgca ttgctaatgt taaggcttgt gaagaaacgt actgtttttc
    11581 tgcttatacc aaaacaactc tgaacaaaaa ataaattagt cgaagattga ttttattagt
    11641 tttattaaac ttgtactcaa tactttacaa tctcgattgt aacaacctaa aaatgtggat
    11701 agtcctaaag ttaggattcg ctcttaaagg tacttttatc tggacttgta gagattcaaa
    11761 ctcaaggaaa aatttagcca aaggacaagt taataatgca aacttaaaaa ttttattcgg
    11821 gtaaggctcc tagaattaat gtagccaagg ttctagtatt tttcgggctg accattagaa
    11881 gttaatgtac tcaaccctaa accctatttc tcaaagattt acagctattt ttgcggtatc
    11941 tatttggatt acttacataa ttctaaaatt gtactcaaac taagaaaagg tattttaaga
    12001 tgtcaatttt ttgtatatag aaatactatt catctttctt tataagttaa ccagatatta
    12061 gaaaaaccta tgagaatcta aaatcttact tttacttgac ccctatactt tgcaactcct
    12121 aacttgtaca tttacatttc ttaagtaata attttggcgt tggtgagtgc gtaatgcttt
    12181 tggtgcaaat atctacgaaa aattaatgtt tcaataactt aatttcttga ttag
//
