LOCUS       c00402_3300002..       11291 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300002858.a:JGI1201J43222_100351.
ACCESSION   c00402_3300002..
VERSION     c00402_3300002..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 04:47:05
            Original ID  :: 3300002858.a:JGI1201J43222_100351
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11291
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..4857
                     /NRPS_PKS="Domain: PKS_KS(Enediyne-KS) (20-480). E-value:
                     2e-92. Score: 302.0. Matches aSDomain:
                     nrpspksdomains_ctg402_1_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (498-958). E-value:
                     2.4e-63. Score: 206.2. Matches aSDomain:
                     nrpspksdomains_ctg402_1_PKS_KS.2"
                     /NRPS_PKS="Domain: PKS_AT (1083-1403). E-value: 1.4e-17.
                     Score: 55.7. Matches aSDomain:
                     nrpspksdomains_ctg402_1_PKS_AT.1"
                     /NRPS_PKS="type: PKS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hglE-KS: hglD"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 118.2; E-value:
                     7.6e-36)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg402_1"
                     /sec_met_domain="PKS_AT (E-value: 1.6e-18, bitscore: 55.7,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 4.4e-65, bitscore: 208.8,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="hglD (E-value: 3.5e-178, bitscore: 580.9,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="ITHYLLPITHYPIPKFIMEKIAIIGYSCLFPDAKNPEEFWQNLIN
                     NQDSTSSVTSEEMGIDPNIFYHPKKGEVDKIYSLKGAFIRDFEFDSNGYSLPGEFLESL
                     DDTFKWSLQVAKQALQHSGYLNQTSLLSKCGVILGTLSLPTKSSNQLFAPIYEQVLGSA
                     IKELLQDENFNLAPLTKLNRPENSNSNSNSNLNSNSNYNAMVSGLPAAIVAQALSLSDI
                     HFSLDAACSSPLYATKLASHYLWTHKADLMIAGGISCADPLFLRMLFSGIQGYPENDFS
                     RPLDKNSRGLATADGVGMVVLKRHSDAIRDGDRIYGVICGNGLSNDGKGKHLLSPNSKG
                     QELAFERAYQEAQLDPKSIDYLECHATGTLLGDTTECNSVENFFGKHQASPLIGSVKSN
                     VGHLLTAAASVSLIKVLLSMSKGVIPATINIDEPMGAENQVISPQSIVTSNTDWSESRG
                     VKRAGISAFGLGGTNAHMILEQGNSETSVNPEEPLKLAKMAIVGMDTFFGGCDGLDAFE
                     RSIYEGKQHFIPLPPKRWYGVENQTELLKKYNFPQGKAPMGAYIEDFEIDTVSSKIPPN
                     ELDKLNQQQLLLLKVAQRALKDAEIKPGSNVAVLIASETELSVHQLQQRWNLAWEIKEG
                     LIAGEISLDADKIKQLETIIKDGVHNPIDSSEYISYIANIMASRISALWDFTAPTFTIS
                     AGENSTFKVLEVAQHLLTTGEADAVLVGAVDLAGGLENVLLRNQQAKVNDNVNTCSFDT
                     KATGWIIGEGAGAVVLKGHEIAKQENQRIYALIDAISFAQQHPQQNLLTDKNLLTDKNP
                     ETVQQVCEKACDLAGITPSQVEYLEVFASGIPKADKAEITGLIGAYPNGGNHLTCAIGT
                     VKANIGHTYVASGIASLIKTALCLYYRYIPATPKWSGVKEEKIWSGSPFYVASESRPWF
                     VGKQASKRIAAINSMGSDGNYAHIILSEEAEQTERSSNYLQKTPFYLFPIAAENRERLI
                     AKVEELQNTIDNADNLATVANQTFQKFQQNPHKSYSIGILGRNRQELTRELTAAIKGIN
                     LAFTKGEDWQTPLGSYFTAQPLGKQGEIAFVYPAAVNSYIGIGRDLFRLFPKTHDDLAI
                     KSADSVAADVSSMVFPRSLNKLSMRQLEKLEQQLLEDSSAIFETDITFAKLITRIIRED
                     FQIKPRFTFGYSLGETSMMSAIGVWNDFNQAIKSFHSSPLFSNRLSGAKNAVREYWGLP
                     PQKQSSNREQNLWGNYVLMTTPEQLRKFLQYEKHAYLTQINTPEEVIIAGDPTACERVI
                     KTLGCNAFRAPFDHVIHCEAMHSEYGEIARVHRLPVAENMSNITLYSSAKYAPISIESN
                     TIAESIAQGLSQQIDFPKLVNRIYKDGAKIFIETGAGNVCSRWINKILDDKPHVCVSLN
                     RRGLDDHTGLLKALAKLLSHQISMNLSPLYSQTEETSKKSKLTLRKVTLGGESFTEKIL
                     TAENRKLFQNVLKKQAKPKVTQEAKNPTTIPASKKAQPTPSSTKTRLKHSASQTKSEKS
                     PMNNISSTNISSKNASSTIVKAIANKSETPSRPIERKLAHTVKLSNSNKSQYQQLRTNN
                     SLAKKTHRSFLKSRHEFSQQIGDIIQLQLICAEHLLSNE"
     protocluster    1..11291
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4857](+)"
                     /cutoff="20000"
                     /detection_rule="(hglE or hglD)"
                     /neighbourhood="20000"
                     /product="hglE-KS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..4857
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(hglE or hglD)"
                     /neighbourhood="20000"
                     /product="hglE-KS"
                     /protocluster_number="1"
     protocluster    1..11291
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4857](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1..4857
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     cand_cluster    1..11291
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(hglE or hglD)"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="chemical_hybrid"
                     /product="hglE-KS"
                     /product="T1PKS"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..11291
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="hglE-KS"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="(hglE or hglD)"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     aSDomain        61..1440
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg402_1_PKS_KS.1"
                     /evalue="2.00E-92"
                     /label="ctg402_1_PKS_KS.1"
                     /locus_tag="ctg402_1"
                     /protein_end="480"
                     /protein_start="20"
                     /score="302.0"
                     /tool="antismash"
                     /translation="IAIIGYSCLFPDAKNPEEFWQNLINNQDSTSSVTSEEMGIDPNIF
                     YHPKKGEVDKIYSLKGAFIRDFEFDSNGYSLPGEFLESLDDTFKWSLQVAKQALQHSGY
                     LNQTSLLSKCGVILGTLSLPTKSSNQLFAPIYEQVLGSAIKELLQDENFNLAPLTKLNR
                     PENSNSNSNSNLNSNSNYNAMVSGLPAAIVAQALSLSDIHFSLDAACSSPLYATKLASH
                     YLWTHKADLMIAGGISCADPLFLRMLFSGIQGYPENDFSRPLDKNSRGLATADGVGMVV
                     LKRHSDAIRDGDRIYGVICGNGLSNDGKGKHLLSPNSKGQELAFERAYQEAQLDPKSID
                     YLECHATGTLLGDTTECNSVENFFGKHQASPLIGSVKSNVGHLLTAAASVSLIKVLLSM
                     SKGVIPATINIDEPMGAENQVISPQSIVTSNTDWSESRGVKRAGISAFGLGGTNAHMIL
                     EQG"
     aSModule        61..1440
                     /domains="nrpspksdomains_ctg402_1_PKS_KS.1"
                     /incomplete
                     /locus_tags="ctg402_1"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       1180..1221
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg402_1_0001"
                     /evalue="2.50E-02"
                     /label="PKSI-KS_m6"
                     /locus_tag="ctg402_1"
                     /protein_end="407"
                     /protein_start="393"
                     /score="7.8"
                     /tool="antismash"
                     /translation="GSVKSNVGHLLTAAA"
     aSDomain        1495..2874
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg402_1_PKS_KS.2"
                     /evalue="2.40E-63"
                     /label="ctg402_1_PKS_KS.2"
                     /locus_tag="ctg402_1"
                     /protein_end="958"
                     /protein_start="498"
                     /score="206.2"
                     /tool="antismash"
                     /translation="AIVGMDTFFGGCDGLDAFERSIYEGKQHFIPLPPKRWYGVENQTE
                     LLKKYNFPQGKAPMGAYIEDFEIDTVSSKIPPNELDKLNQQQLLLLKVAQRALKDAEIK
                     PGSNVAVLIASETELSVHQLQQRWNLAWEIKEGLIAGEISLDADKIKQLETIIKDGVHN
                     PIDSSEYISYIANIMASRISALWDFTAPTFTISAGENSTFKVLEVAQHLLTTGEADAVL
                     VGAVDLAGGLENVLLRNQQAKVNDNVNTCSFDTKATGWIIGEGAGAVVLKGHEIAKQEN
                     QRIYALIDAISFAQQHPQQNLLTDKNLLTDKNPETVQQVCEKACDLAGITPSQVEYLEV
                     FASGIPKADKAEITGLIGAYPNGGNHLTCAIGTVKANIGHTYVASGIASLIKTALCLYY
                     RYIPATPKWSGVKEEKIWSGSPFYVASESRPWFVGKQASKRIAAINSMGSDGNYAHIIL
                     SEE"
     aSModule        1495..4209
                     /domains="nrpspksdomains_ctg402_1_PKS_KS.2"
                     /domains="nrpspksdomains_ctg402_1_PKS_AT.1"
                     /incomplete
                     /locus_tags="ctg402_1"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       2608..2652
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg402_1_0002"
                     /evalue="5.20E-02"
                     /label="PKSI-KS_m6"
                     /locus_tag="ctg402_1"
                     /protein_end="884"
                     /protein_start="869"
                     /score="7.0"
                     /tool="antismash"
                     /translation="GTVKANIGHTYVASGI"
     aSDomain        3250..4209
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg402_1_PKS_AT.1"
                     /evalue="1.40E-17"
                     /label="ctg402_1_PKS_AT.1"
                     /locus_tag="ctg402_1"
                     /protein_end="1403"
                     /protein_start="1083"
                     /score="55.7"
                     /specificity="PKS signature: (unknown)"
                     /specificity="consensus: pk"
                     /specificity="Minowa: isobut"
                     /tool="antismash"
                     /translation="VNSYIGIGRDLFRLFPKTHDDLAIKSADSVAADVSSMVFPRSLNK
                     LSMRQLEKLEQQLLEDSSAIFETDITFAKLITRIIREDFQIKPRFTFGYSLGETSMMSA
                     IGVWNDFNQAIKSFHSSPLFSNRLSGAKNAVREYWGLPPQKQSSNREQNLWGNYVLMTT
                     PEQLRKFLQYEKHAYLTQINTPEEVIIAGDPTACERVIKTLGCNAFRAPFDHVIHCEAM
                     HSEYGEIARVHRLPVAENMSNITLYSSAKYAPISIESNTIAESIAQGLSQQIDFPKLVN
                     RIYKDGAKIFIETGAGNVCSRWINKILDDKPHVCVSLNRR"
     CDS             4963..6624
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 526.8; E-value: 1.3e-159)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg402_2"
                     /transl_table=11
                     /translation="MNTTNLPLNKPNNGLGYYTSLSNQHRGWKGSLACVSFDPTDIRDK
                     LQTLSKPCYIVKVEDRIGVTNDGYCPLDNGKKAQIEVLFDLPPLSIKQLGDPTFLSFHN
                     VKYAYTTGAMAGGIASEEMIIALGKAKILGSFGAGGLTPERLEAAIKRIQQALPNGPYA
                     FNLIHSPNDPEIERKAVDLYLKHGVRTVEASAFLDLTPNIVYYRAAGLSVNSASEIEIK
                     NKVIAKISRREVASKFMQPAPLKILKQLLEQGLITELQATLAAKVPIADDITAEADSGG
                     HTDNRPLVCLLPSIIALRDEIQAKYNYKKPIRVGVAGGIATPQSALAAFMMGAAYVVTG
                     SINQSCIEAGTSPHTKKLLAQAAMADVMMAPAADMFEMGVKLQVLKRGTMFPMRAQKLY
                     EIYRNYNSIEDIPTAEREKLEKQVFRQTIDEAWKATIDYLSQKNPQKLQKANSNPKMKM
                     ALIFRRYLGLSSRWSNSGEKGREVDYQIWCGPAMGSFNDWVRNSYLAEANNRRVVDVAN
                     HIMKGTAYLYRIQSLKLQGLQISDYYTQYIPNFSTL"
     CDS             6662..8197
                     /NRPS_PKS="Domain: ACP (17-87). E-value: 9.9e-18. Score:
                     56.0. Matches aSDomain: nrpspksdomains_ctg402_3_ACP.1"
                     /NRPS_PKS="Domain: TD (141-381). E-value: 4.5e-86. Score:
                     279.7. Matches aSDomain: nrpspksdomains_ctg402_3_TD.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047:phosphopantetheine-binding domain-containing
                     protein (Score: 80.2; E-value: 1.7e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg402_3"
                     /sec_met_domain="PP-binding (E-value: 2.7e-16, bitscore:
                     48.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.3e-71, bitscore:
                     229.3, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.8e-08,
                     bitscore: 21.8, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTSDISQTLNTAEEIQDWMTSKLAEILKVSPEEIDIQQSLEDYG
                     LDSANAMVLVTQTEKKLGLQLSPTLLWHYPNIESLSQRLAEEIEVSDKDNSQTVENNHT
                     SPFANSKSVPNLAAEAVLDESIYPASKSFHFTANPENVFLTGGTGFLGAFLIYQLLQET
                     DADIYCLVRAADLEEARNKLKNKLKQYAIWHEEYSPRIIPVLGDLSQPLLGISKEAFEM
                     LAANMDAVYHSGAQLNYVYPYSALKAANVLGTQEVLRLGCLIKVKPVHYVSSVAIFESP
                     TYAGQVVKENDEFEHWEGIFLGYSQTKWVAEKLVKIAGERGLPVTIHRPPLISGDSRTG
                     VCNPDDFINLALKGCIQMGVFPDVDYMLDASPVDYVSKAIVHLSRQKESLGQAFHLQHP
                     EPVPFTTLVDWLKSLGFPIAVIPYERWQTMLVENLSSPDNPLYTLRPFLLERWTEEGLT
                     IPDLYLQANRPIVSTEATVDALAPGNVVCPPIDSQLFMAYSTYLIQNGFLEVG"
     aSDomain        6713..6922
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg402_3_ACP.1"
                     /evalue="9.90E-18"
                     /label="ctg402_3_ACP.1"
                     /locus_tag="ctg402_3"
                     /protein_end="87"
                     /protein_start="17"
                     /score="56.0"
                     /tool="antismash"
                     /translation="DWMTSKLAEILKVSPEEIDIQQSLEDYGLDSANAMVLVTQTEKKL
                     GLQLSPTLLWHYPNIESLSQRLAEEI"
     aSModule        6713..7804
                     /domains="nrpspksdomains_ctg402_3_ACP.1"
                     /domains="nrpspksdomains_ctg402_3_TD.1"
                     /final_module
                     /incomplete
                     /locus_tags="ctg402_3"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        7085..7804
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg402_3_TD.1"
                     /evalue="4.50E-86"
                     /label="ctg402_3_TD.1"
                     /locus_tag="ctg402_3"
                     /protein_end="381"
                     /protein_start="141"
                     /score="279.7"
                     /tool="antismash"
                     /translation="VFLTGGTGFLGAFLIYQLLQETDADIYCLVRAADLEEARNKLKNK
                     LKQYAIWHEEYSPRIIPVLGDLSQPLLGISKEAFEMLAANMDAVYHSGAQLNYVYPYSA
                     LKAANVLGTQEVLRLGCLIKVKPVHYVSSVAIFESPTYAGQVVKENDEFEHWEGIFLGY
                     SQTKWVAEKLVKIAGERGLPVTIHRPPLISGDSRTGVCNPDDFINLALKGCIQMGVFPD
                     VDYMLDASPVDYVSKAIVH"
     CDS             8263..8508
                     /locus_tag="ctg402_4"
                     /transl_table=11
                     /translation="LEVWDFSYLIRISLYLKLYFVSIYPTNGYPLDLLIEMGYSGTRKN
                     ARQTIGQSRDGGVDGIINEDRLGLDVIHIQAGKTLG"
     CDS             complement(8804..9895)
                     /locus_tag="ctg402_5"
                     /transl_table=11
                     /translation="MINLHLQAIGKAEEMIDYTNVSRCVAQLQEFIALHPEANEVRKAL
                     AVKLVYQGYFYEEIQTILGVSPSSLQFWKTSYEKYGIDGLRLQDKEAQKVLIKISQKLK
                     LNDLIDLLNGKYLALRIPNYYPVREAKKISQELIEEKTLERYNRAPDVGVQRTGITFFE
                     TSCSVEMLKRYYEQAQVSIQALRKTCFPHLSPLDKLRLELQEIWVPGAHIENIHNQTML
                     VGVGRVFEDNFELPPHQDVFARDISDVGIPPAHPFDNFVTQLSANIYLQTPKSGGELEV
                     WELKPSIPAREAIRDQEYKYEGILDRNSLPSATLKIKPKVGELILFDSGRIHGVRPCQD
                     GPRVSMSMFIGYRSREKPLTYWS"
     CDS             complement(11150..11290)
                     /locus_tag="ctg402_6"
                     /transl_table=11
                     /translation="CYLPPYSPDLNRIEKCWSWLKSRIRKQLENFGTLREAMEHVLTLA
                     S"
ORIGIN
        1 attacccatt acctattacc catcacccat tacccaatcc ccaaatttat tatggaaaaa
       61 attgcaataa ttggttattc atgtctattc cccgatgcaa aaaatccaga agaattttgg
      121 caaaatctta ttaataatca agattcaaca tcatctgtta cttctgaaga gatggggata
      181 gaccccaata ttttttatca tcctaaaaaa ggtgaagtcg ataaaattta ttctttaaaa
      241 ggtgcattta ttcgtgattt tgagtttgac tccaatggat atagtttacc tggagaattt
      301 ttagaaagct tagatgacac ctttaaatgg tcactccaag ttgcaaaaca agctttacaa
      361 catagtggtt atttaaatca aacttcttta ctttctaaat gtggggttat tttaggtacc
      421 ctttccttac caacgaaatc ttctaaccaa ttatttgctc ccatctatga gcaggtgctt
      481 ggatctgcga tcaaagaact tttacaagat gaaaacttta atttagctcc actgacaaaa
      541 ttaaatagac ctgaaaattc aaattcaaac tcaaattcaa atttaaactc aaactcaaac
      601 tataatgcaa tggtttctgg tttaccagca gcgatcgttg ctcaagcttt gtctctttca
      661 gatatccatt tttcccttga tgctgcttgc tcttctccat tgtatgcaac taaattagca
      721 tcccattatt tatggaccca taaagccgat ttaatgatag ctggaggtat tagctgcgca
      781 gatccattat ttttacgaat gctgttttcg ggaattcaag gttatccgga aaacgatttt
      841 agccgtcctt tagataaaaa ttcccggggt ttagctaccg ctgatggtgt gggaatggta
      901 gttctcaaac gtcacagcga tgcaattcga gatggcgatc gcatttatgg agttatctgc
      961 ggtaatggtc tttctaatga tggtaagggt aaacatttac tcagtcccaa ctccaaagga
     1021 caggaactag cttttgaaag agcttaccaa gaagcacaac tcgatccaaa aagtattgat
     1081 tatttggaat gtcatgcaac tggtacttta ctcggagata ccaccgaatg caattccgta
     1141 gaaaacttct ttggtaaaca tcaagcgagt ccattaatag gttctgtcaa aagcaatgtg
     1201 ggtcatttac ttaccgctgc tgcttctgtc agtttaatta aagtcctttt aagtatgtcc
     1261 aagggagtta tcccagcaac tatcaatatt gatgaaccta tgggtgcaga gaatcaggta
     1321 atttcgcccc aaagtattgt cacaagtaat actgattggt cagagagtag aggcgtgaaa
     1381 agggcgggta ttagtgcgtt tggtttgggt ggtactaatg ctcatatgat tctcgaacag
     1441 ggtaattcag agacatcagt taacccggaa gaaccactga agctagcaaa aatggcgatt
     1501 gtgggaatgg ataccttttt tggtggttgt gatggtttag atgcttttga acgtagtatc
     1561 tatgaaggaa aacaacattt tattccctta cctccaaaaa gatggtacgg agtcgaaaat
     1621 caaacagaat tactgaaaaa atataatttt ccccaaggta aagcgccgat gggtgcttac
     1681 attgaagact ttgaaattga tactgtctct agcaaaattc cacccaacga actagataaa
     1741 cttaaccaac aacagctttt attgctcaaa gttgctcaac gagccttaaa agatgcagag
     1801 atcaagccag gtagtaatgt tgcggtttta atcgctagcg aaacagaact ttcggttcac
     1861 caattacaac aaagatggaa tttagcttgg gagattaaag aaggcttaat tgctggagaa
     1921 atttccttag atgccgataa gattaagcaa ttagaaacga ttattaaaga tggagtccat
     1981 aatccgatag atagcagcga atacatcagt tatattgcta atatcatggc aagtcggatt
     2041 tctgctttat gggattttac cgctccgaca tttacgatta gtgctggtga aaattctact
     2101 tttaaggttt tggaagttgc acaacacctg ttaactactg gggaagctga cgctgttcta
     2161 gtcggtgcgg tggatttagc aggtggttta gagaatgttt tgcttcggaa tcaacaagcg
     2221 aaggtcaatg ataatgttaa cacttgttct tttgatacta aagctactgg ttggatcata
     2281 ggtgaaggtg cgggtgctgt tgttctcaaa ggtcatgaaa tcgccaaaca ggagaatcag
     2341 cggatctatg cattaattga tgcaattagt tttgcacagc aacacccaca acaaaactta
     2401 ctaactgaca aaaatctact aactgataag aatccagaaa cggttcagca agtatgtgag
     2461 aaagcttgcg atcttgctgg aattacacca tcccaagttg aatatttgga agtttttgct
     2521 agcggtattc ccaaagcaga taaagcagaa attacgggtt taattggagc ttatcccaac
     2581 ggtgggaatc atttaacttg tgcaattggt acggttaaag ccaatatcgg tcatacctat
     2641 gtagcctcgg gaattgctag tttaattaaa actgctttgt gtttgtatta tcgatatatt
     2701 cccgcaactc ccaaatggtc tggtgtcaaa gaggaaaaaa tctggtcggg tagtccgttc
     2761 tatgtcgctt cagaatcaag accttggttc gttggtaaac aagcaagcaa aagaattgca
     2821 gctattaata gtatgggaag cgatgggaat tatgcccata taattctctc cgaagaagca
     2881 gaacaaacag aacgcagtag taattattta cagaaaacac ctttttatct cttcccgatc
     2941 gccgctgaaa atcgcgagcg attaatagct aaggtcgaag aattacaaaa tactattgat
     3001 aatgcagaca atcttgctac agtagcaaat caaactttcc aaaaatttca acaaaatccc
     3061 cacaaaagct acagtatagg gattttagga cggaatcgcc aagaattaac cagagaatta
     3121 acagccgcaa ttaaaggaat taacctcgca tttacaaaag gtgaagattg gcaaacacct
     3181 ttaggtagtt actttacagc ccaaccctta ggaaaacaag gggaaattgc ttttgtttat
     3241 cctgctgcgg ttaattccta tatcggtatc ggtcgcgatt tgttccgttt atttcccaaa
     3301 acccatgatg acttagcaat aaaaagtgct gatagtgttg ctgctgatgt ttcgagtatg
     3361 gtctttcccc gcagcttaaa taaattatcc atgagacagc tggaaaaact cgaacagcaa
     3421 cttttagagg attcctcagc catctttgaa actgatatca cgtttgccaa attaattact
     3481 aggattatcc gtgaagactt ccaaataaaa cctcgattta cctttggtta cagtttaggc
     3541 gaaaccagta tgatgtctgc aattggtgtc tggaatgact tcaatcaagc catcaaatcc
     3601 ttccattcct ctccactatt tagtaataga ttatccggtg ctaaaaacgc cgtacgggaa
     3661 tattggggac taccacctca aaaacaatcc tcaaatcgag agcaaaacct ctggggtaat
     3721 tatgtcttga tgacaactcc agaacaactg agaaaattcc tccaatatga aaagcatgct
     3781 tatttaactc aaattaatac tccagaagaa gtcataattg caggagatcc cacagcttgc
     3841 gaacgagtta ttaaaacctt gggttgcaac gcttttcgtg ctccctttga ccatgtaatt
     3901 cactgcgaag cgatgcattc ggaatatggg gaaatcgcca gggttcacag attaccagtt
     3961 gcagaaaaca tgtccaatat taccctgtat tcttccgcca aatacgcccc catatccatt
     4021 gaaagcaaca caatagccga gagtatcgct caaggtttat cgcaacaaat tgattttccc
     4081 aaactcgtca atcgtattta taaagatgga gccaaaatat ttatcgaaac cggtgcgggt
     4141 aacgtttgtt cgcgatggat taacaaaatt ctcgatgata aaccacatgt ttgtgtctcc
     4201 ctcaaccgga gagggttaga tgaccatacg ggactactta aagcattagc aaaactttta
     4261 agccatcaaa tatctatgaa tttgtcgcca ctatacagtc aaacagaaga aaccagcaaa
     4321 aaatcaaaat tgacactacg aaaagttacc ttgggagggg agagttttac cgagaagatt
     4381 ttaacagcag aaaacagaaa actgtttcag aacgtactta aaaaacaagc aaaaccaaaa
     4441 gttacccagg aagcaaaaaa cccgaccacc atacccgcaa gtaaaaaagc tcaacctacc
     4501 ccatcatcca ccaaaacccg tttgaagcac tcagcatccc aaaccaagtc tgagaaatcg
     4561 cctatgaata atatctccag cacaaatatc tccagtaaaa acgcctccag cacaatagtc
     4621 aaagcgatcg ccaacaaatc cgaaactcca tctcgtccaa tcgagcgaaa actagctcat
     4681 acagtcaagc tctctaactc aaataaatct caatatcaac aattaagaac taataactca
     4741 ctagcgaaaa aaacccatag atctttcctt aaatctcgac atgaattcag ccaacagatt
     4801 ggtgacatta ttcaattgca actaatttgt gcagaacacc tgttgagtaa tgagtaagag
     4861 taagaagtaa ggagtaacat aattacccaa tcgccacata acccccacct aacctccccc
     4921 aagtgaggaa taaatactaa tcgccagtcg caaatcccca acatgaacac cacaaacctc
     4981 ccattaaaca agccaaacaa tggtcttggc tattacacat ctttatccaa tcaacatcga
     5041 ggttggaaag gttcattagc ttgtgtgtcc tttgatccca cagatattag agataaactc
     5101 caaacattaa gtaaaccgtg ttacatcgtc aaagttgaag accgaattgg tgtaactaat
     5161 gacggttatt gtccccttga taatggtaaa aaggcacaga tagaagtttt atttgacctt
     5221 cctcccctat ctattaaaca attaggcgac cccacttttc tttcctttca taatgttaaa
     5281 tacgcctaca caaccggagc aatggctggt ggtatcgcct cagaggaaat gattatcgcc
     5341 ctaggaaaag caaaaatcct tggttctttc ggtgcaggtg gtttaactcc agaacgatta
     5401 gaagctgcaa ttaaacgtat tcaacaagct ttacccaatg gaccttatgc ttttaactta
     5461 attcatagtc ccaacgatcc agaaattgaa cgtaaagctg tggacttgta ccttaaacat
     5521 ggggtaagaa cagttgaagc atcagcattt ttagatttaa cacccaatat tgtttattat
     5581 cgcgctgcag ggctaagtgt aaactcagcc tcagaaatag aaataaaaaa taaagtcatt
     5641 gctaaaattt cccgtcgcga agttgcaagt aaattcatgc aaccagcacc acttaaaatc
     5701 ctcaagcaac tcctagagca aggattaatt accgaattac aagcaacctt agcagcaaaa
     5761 gttcccattg ctgatgatat tacagccgaa gcagactccg gtggtcatac ggataatcga
     5821 cctttagttt gtcttttacc atcaataatt gccttaagag atgaaattca ggcaaaatat
     5881 aactacaaaa aacccattcg agtgggagta gcgggaggaa ttgcaacccc ccaatccgcc
     5941 cttgcagcat ttatgatggg tgcagcctat gtagttactg gttcaattaa tcaatcttgc
     6001 attgaagccg gaacctctcc acatactaaa aaattattag cccaagctgc tatggctgac
     6061 gtgatgatgg ctccagcagc agatatgttt gaaatggggg tcaaactcca agtactcaaa
     6121 cggggaacaa tgtttcctat gcgagcacaa aaactatatg aaatatatcg gaattacaac
     6181 tcaattgaag atatccccac agccgaaaga gagaaattag aaaaacaagt ttttcgccaa
     6241 actattgacg aagcatggaa agcaaccatc gattatttat cccaaaaaaa tccccagaaa
     6301 ctccaaaaag caaatagcaa tccaaaaatg aaaatggcgt tgattttccg ccgctatttg
     6361 ggactatctt cccgatggtc taactcaggg gaaaaaggtc gagaagtcga ttatcaaatt
     6421 tggtgcggtc cggcgatggg gagctttaat gattgggtaa gaaattcata cttagctgaa
     6481 gcaaataatc gccgagtggt tgatgttgca aatcacatca tgaaaggtac cgcttactta
     6541 tacagaattc aaagtctcaa acttcaagga ttacaaatat ccgattacta cactcaatac
     6601 attcccaact tctcaacatt ataacttcaa cactagagtt tcaagattag aggtgtgatt
     6661 aatgatgact tcagacattt cacaaacatt aaatacagcc gaagaaatcc aagactggat
     6721 gacatctaag ctagcagaaa ttcttaaagt tagccccgaa gaaatagata ttcaacaatc
     6781 attagaagat tatggcttag actcagcaaa tgccatggtt ttagtcaccc aaactgaaaa
     6841 aaaattggga ttacaactat caccaacatt attatggcat tatccaaata ttgaatcact
     6901 ttcccaacgt ttagctgaag aaattgaagt atcggataaa gataatagcc aaacagttga
     6961 gaataatcat acttcaccct ttgcaaatag taaatctgta ccgaatttag cagcagaagc
     7021 agtcctcgac gaaagtatct accctgcatc caaatctttt cactttacag ctaatccaga
     7081 aaatgtattt ttaacagggg gaactggctt tttaggtgca ttcttaattt accaattact
     7141 ccaagaaaca gatgcagata tttattgctt agtacgtgct gctgacttag aagaagctag
     7201 aaataaactc aaaaataaac ttaagcaata tgccatttgg catgaagaat atagtcctag
     7261 aattattcct gttttaggtg acttatccca accattactg ggtattagta aagaagcttt
     7321 tgaaatgtta gctgcaaaca tggatgcagt ttatcatagt ggggcacaat taaattatgt
     7381 ttatccttac tcagcactca aagcagcaaa cgttttagga acccaagaag ttttacgttt
     7441 gggatgttta attaaagtta aacccgtaca ttatgtttcc agcgttgcaa tatttgaatc
     7501 tcctacttat gctggtcaag tggtcaaaga aaacgatgaa ttcgaacatt gggaaggaat
     7561 ttttcttggt tactcccaaa ctaaatgggt cgcagaaaaa ctcgtaaaaa tagccggaga
     7621 aagaggactt cccgttacca tccacagacc accattaatt tctggagata gtcgcaccgg
     7681 ggtttgcaat ccagatgatt ttattaacct agctctcaaa ggttgtatcc aaatgggagt
     7741 tttccctgat gtagattaca tgttggacgc atcccccgta gattacgtta gtaaagcgat
     7801 cgttcaccta tcccgacaaa aagaatccct cggtcaagca tttcacttac agcatccaga
     7861 accagttccc ttcaccacct tggttgattg gttgaaatcc ttaggctttc ccattgctgt
     7921 cattccttat gaaagatggc aaactatgtt agtggaaaac ttatcctctc cagataatcc
     7981 tctgtatact ctaagacctt tcctcttaga acgctggaca gaagagggac taactatacc
     8041 agatttatac ttacaagcaa acagacctat tgttagcact gaagcgaccg tagacgcact
     8101 tgctcccggt aatgttgttt gtccaccaat agactctcaa ttatttatgg cttactccac
     8161 ttacctaatt caaaatggtt ttctggaagt aggttaattt cttaggttta acttttttag
     8221 gtttaacgtc catcagtccc atcttttcaa gtagataatt gcttggaagt atgggacttt
     8281 tcttatttaa taagaatcag tttatacttg aaactgtatt ttgtaagtat ttatcctact
     8341 aacggctatc cccttgattt actaattgag atggggtata gcggtacccg caaaaatgcc
     8401 agacaaacaa taggacagag ccgtgatggt ggagtagatg gaattatcaa cgaagatcgt
     8461 cttggactag acgtgattca tattcaggca ggcaaaacat tgggataatt ctgttggtcg
     8521 cccagaagtg caaaaatttg caggaaattt gcacttctgg aggaggaaag ggatttttat
     8581 cacaacagca acatttacca aggaagctaa agactttgtt tcaagaattg ataaccggat
     8641 aatccttatc gatggagaaa cccttgcttt actgatgatt gaaaataatg ttggggttac
     8701 atcactcgaa tcctatgaaa tcaagaaaat ttgctcggat ttttttaacc gatgcctgaa
     8761 taaaaataaa tacgcattga gaaatttata atgaaaaaaa ctactagctc caatatgtca
     8821 aaggcttttc cctagaacga tatccaataa acatagacat agaaactcgc ggaccatctt
     8881 gacaagggcg aacaccatga attcttccag aatcaaatag aatcaattcc ccaacttttg
     8941 gcttaatttt taatgttgca cttggtaaac tgttgcgatc gaggatcccc tcatatttat
     9001 attcttgatc gcgaattgct tctcgtgcag gaatagacgg ctttagttcc caaacctcta
     9061 actcacctcc agatttagga gtttgtaaat aaatgtttgc agacaactga gtaacaaagt
     9121 tatcgaaggg atgagccgga ggaataccaa catccgagat atcccgtgca aaaacatctt
     9181 ggtggggtgg taattcaaag ttatcctcaa atacacgacc aactccaacc aacatcgttt
     9241 gattatggat attttcaata tgagcgcccg gtacccagat ttcttgtaac tctaacctga
     9301 gtttatcgag gggtgacaaa tgagggaaac aggtttttcg aagagcttga atcgaaactt
     9361 gagcttgttc gtaataacgc ttgagcattt ctacagaaca actagtttca aagaaagtaa
     9421 ttccagttct ttgtactcct acatctggcg ctctgttata acgctctaaa gttttttctt
     9481 cgatcagttc ttgactaatt ttctttgctt ctcgaactgg gtaataatta ggaatgcgta
     9541 gtgcaaggta tttgccattt aatagatcga ttaagtcgtt taattttagt ttttgggata
     9601 tttttattag tactttttgg gcttctttat cctgcaagcg taacccgtct attccatatt
     9661 tttcataaga tgttttccaa aattgcagag aactagggga tacacctaag attgtctgta
     9721 tttcttcgta aaagtagcct tgataaacaa gcttaacagc taatgctttt cttacctcat
     9781 tagcttctgg gtggagagcg ataaattctt gcaattgggc tacacatcga gaaacatttg
     9841 tgtagtctat catctcttcc gcttttccta tagcctgtag atgcagattt atcatggtct
     9901 tttgttagag tgacatagcc ataaatccat aagtattttc gcttactact taaaaaaaat
     9961 caaattaaat actttcttta atgtactgct tgaaggtgtg tataatttgt ttttatgcta
    10021 aaagacaaaa atactgaaag tgatgtaata aatgcctcaa gttattgtat acaagtactt
    10081 ccgaagattt atattgagat aaactgcaat acacagctat atttaattta ttatttaata
    10141 agcttatttt agtattatct ttattctaaa tttatggctt ggaagtaaga atgaaaaata
    10201 ttgtcaattt atttaagctg ctcattaata ataataaata aaaacaaata atgttattcg
    10261 ttaacctttt aaaaatttac cttagttttt gattaagaag aacagaccta taagccacta
    10321 gtagtaaatg cgtagaaaca atgattatat aaaaaatatt taagtttacg aaacgacaaa
    10381 aaaatatcat aaatataagt gtaataaaat atttaaatat aattgcggat gagatacagg
    10441 caataatata tgcacattta tcgttattta tggacttttt atatatttgt ttttcatgtt
    10501 taataatcat taacaaacaa agttatgaag agaaaccgta caagctatat aatggcaaga
    10561 aggtcaaaaa acaacattaa ttttgacaat tatctcttga ttagcaatgg aaagagtaga
    10621 gtaaattttg ttcaatggat gattttggga atctatcatt aaacgcttaa ctgctaactt
    10681 aagagtgagc ttatctggtc gaataccaga tattttgaga ggtgtgtagg aagagttcaa
    10741 tcgttctatt tattgatgtc aatttcatcg aaaattgcaa tcaatttgac tgactatcat
    10801 cctttttgtt ttcccctgta agtttttgga tcgagagtgg aagacgtcac agtgaatgca
    10861 gaaacattat ctggtattta gctgctaaaa atcaagttac tactatttcc gcagccttga
    10921 attatatcct agataaaaat tctaaaaatg aggaaaaaca tttcaagctg tatggactat
    10981 aaattttgca tttgtgttga tcgcctcaac tttaggctta gtttttgcag actaaatgtt
    11041 tgctattcca ttcgtataag tccgatcaaa acaggttgga ttaatctatg caagaaaatt
    11101 tccacagaga ataccttttt attgaatact atagcaaccg ccaggttagc taggacgcta
    11161 aagtcaagac atgctccatg gcttctcgca gtgttccaaa attctcgagt tgtttgcgaa
    11221 ttcgactttt tagccatgac cagcattttt caatccggtt taaatctggt gaataaggtg
    11281 gtaagtagca c
//
