LOCUS       c00447_3300002..        5538 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300002858.a:JGI1201J43222_100574.
ACCESSION   c00447_3300002..
VERSION     c00447_3300002..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 04:47:05
            Original ID  :: 3300002858.a:JGI1201J43222_100574
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5538
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..444
                     /NRPS_PKS="Domain: PCP (47-113). E-value: 1e-16. Score:
                     52.6. Matches aSDomain: nrpspksdomains_ctg447_1_PCP.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg447_1"
                     /sec_met_domain="PP-binding (E-value: 5.7e-16, bitscore:
                     46.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="DYMVPSAFVTLDSLPLTPNGKIDRKALPTSDINLTRSHEYVPPQT
                     ETEKHIAGVLQEVLQLEKVSINDNLFELGANSLTLVTINIKLRQILSIELPLVDMFTYP
                     NIKTLSQHIVNINNPESLIKEQLLSRRQIKSSMKKRRKLREKL"
     protocluster    1..5538
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[482:5132](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      483..5132
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..5538
                     /SMILES="CC(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..5538
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     CDS_motif       58..84
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_1_0001"
                     /evalue="3.30E-03"
                     /label="NRPS-A_a10"
                     /locus_tag="ctg447_1"
                     /protein_end="28"
                     /protein_start="19"
                     /score="9.6"
                     /tool="antismash"
                     /translation="GKIDRKALPT"
     aSDomain        142..339
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg447_1_PCP.1"
                     /evalue="1.00E-16"
                     /label="ctg447_1_PCP.1"
                     /locus_tag="ctg447_1"
                     /protein_end="113"
                     /protein_start="47"
                     /score="52.6"
                     /tool="antismash"
                     /translation="EKHIAGVLQEVLQLEKVSINDNLFELGANSLTLVTINIKLRQILS
                     IELPLVDMFTYPNIKTLSQHIV"
     aSModule        142..339
                     /domains="nrpspksdomains_ctg447_1_PCP.1"
                     /incomplete
                     /locus_tags="ctg447_1"
                     /tool="antismash"
                     /type="unknown"
     CDS             483..5132
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (8-435). E-value:
                     9.1e-167. Score: 547.0. Matches aSDomain:
                     nrpspksdomains_ctg447_2_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (532-828). E-value: 2e-102.
                     Score: 334.3. Matches aSDomain:
                     nrpspksdomains_ctg447_2_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1161-1359). E-value: 2e-50.
                     Score: 163.0. Matches aSDomain:
                     nrpspksdomains_ctg447_2_PKS_KR.1"
                     /NRPS_PKS="Domain: PCP (1458-1526). E-value: 1.3e-19.
                     Score: 61.9. Matches aSDomain:
                     nrpspksdomains_ctg447_2_PCP.1"
                     /NRPS_PKS="type: PKS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 67; E-value:
                     2.1e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg447_2"
                     /sec_met_domain="PP-binding (E-value: 1.5e-18, bitscore:
                     55.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.2e-103, bitscore:
                     334.3, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 7e-177, bitscore: 576.1,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.8e-38, bitscore:
                     119.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDINDLDIAIIGLSGRFPQAKNIDSFWKNIKNGVESIHFFSEEE
                     LLEEGISSNLLKNPNYVKAKAVLADVEMFDANFFGFSSKEAKLIDPQQRLFLESAWEVI
                     ESAGYDPEKYSGSIGVYAGTSSNTYLLNNIYPKFDAEDFAGIYQLMLSSNKDFLPTRVS
                     YKLNLKGPAVNVQTACSTSLVAVHIACQSLLNGECDMALAGGVSISIPQKTGYLYSEGM
                     IASPDGHCRAFDAKAEGTLGSSGLGIVLLKRLEDAIADKDCIHAVIKGSAINNDGSVKV
                     GFTAPSTEGQAAVIAQAQAVAEVDAESITYIEAHGTGTKLGDPIEIAALTKAFRKSTDK
                     KQFCAVGSLKTNMGHLDAAAGVGGLLKTVLALKHKVIPPSLHFEEPSPNIDFANSPFYV
                     NTALSEWNSNGNPRRAGVSSFGIGGTNAHVILEEAPPLPASGDSRKQHLLLISAKTISA
                     LEQATANLGKYLQENPDTNLADVAYTLSCGRRNFVHRRMLVCQSTEDAVTVLGDVDSQN
                     IFTNTVGATDKPVVFMFPGQGSQYVNMALELYETESLFREQVDFCAEILKPELELDLRQ
                     ILYPQPEKIQVAEQQLQQTAIAQVAIFVVEYALAKLWQSWGVSPQAMIGHSIGEYVAAT
                     LAGVFSLEAALCLVAARGKMMQQLPGGTMLSIPVSAEEVKPLLTAEISIAAINEPSRCV
                     ASGSTEAIEILESKLASQSIECRRLHTSHGFHSQMMEPILDKFKQRVEQESLKAPQIPY
                     ISNLTGDWITEAQAKDANYWVQHLRQTVLFAQGIENILSNPEQVLLEVGPGRTLTSLTK
                     RHPAHNKEQLVLTSVRHPKEDKSDIACLLTTVGNLWLAGVNVDWLAFYSQEERYRVPLP
                     TYPFERQRYWISPPTLEEKVKSKKQEISKQEISKTSDISQWFYVPSWKRVPLAPSQLKK
                     SPGHILLFVDEYGLGEKLTVQLTQMDEKVICVQVGDSFTKQSEGVYTVNPQQADDYNTL
                     VNELVKLDIIPKQVIHLWSLTKENSEASLRVNLDYEVFDKAQDLGFYSLLFIVQALGKQ
                     ASVDTCEFSVISNKLFDVIGEDELSPEKTTLLGPIRTIYQEYFNFNCRCIDVILPQSET
                     RKEKIFIDNLIAELTTASNEQIIAYRGKSRWIESFESFTLQPQVNSGKQNLKQQGTYLI
                     TGGLGNIGMLLAEYLAKNFSANLILIGRSTFPDRDSWSEWLDKHNEQDTISRKIRKFKE
                     LEALGAKILVESADVSNLQEMQSVIEKAENKFGVINGVIHAAAVVEDSPIEKTSKAECK
                     QQFLSKVSGVLVLEKLLANKNLDFCLLMSSLLSILGGLGFVTYGASNSFLDSFVNARSH
                     KENNFPWITVNWDDWEVDKEETQNQGLDKKLRTLAINPEEGIKAFELILSGINFLSGLN
                     TNQIVVSTSDLELRVNKLAKCNSLKGKNNLEKYSDSQASNQRNVTNAYVPPRNEIDEKI
                     IEIFQSLLGNTNIGINDDFFELGGDSLIGTMLIAKVKQEFKININLSDVFNLTTVAQIS
                     EHITNQQQSSQNDLKRISEILEIVDIMPD"
     aSDomain        507..1787
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg447_2_PKS_KS.1"
                     /evalue="9.10E-167"
                     /label="ctg447_2_PKS_KS.1"
                     /locus_tag="ctg447_2"
                     /protein_end="435"
                     /protein_start="8"
                     /score="547.0"
                     /tool="antismash"
                     /translation="IAIIGLSGRFPQAKNIDSFWKNIKNGVESIHFFSEEELLEEGISS
                     NLLKNPNYVKAKAVLADVEMFDANFFGFSSKEAKLIDPQQRLFLESAWEVIESAGYDPE
                     KYSGSIGVYAGTSSNTYLLNNIYPKFDAEDFAGIYQLMLSSNKDFLPTRVSYKLNLKGP
                     AVNVQTACSTSLVAVHIACQSLLNGECDMALAGGVSISIPQKTGYLYSEGMIASPDGHC
                     RAFDAKAEGTLGSSGLGIVLLKRLEDAIADKDCIHAVIKGSAINNDGSVKVGFTAPSTE
                     GQAAVIAQAQAVAEVDAESITYIEAHGTGTKLGDPIEIAALTKAFRKSTDKKQFCAVGS
                     LKTNMGHLDAAAGVGGLLKTVLALKHKVIPPSLHFEEPSPNIDFANSPFYVNTALSEWN
                     SNGNPRRAGVSSFGIGGTNAHVILEEAPP"
     aSModule        507..5060
                     /complete
                     /domains="nrpspksdomains_ctg447_2_PKS_KS.1"
                     /domains="nrpspksdomains_ctg447_2_PKS_AT.1"
                     /domains="nrpspksdomains_ctg447_2_PKS_KR.1"
                     /domains="nrpspksdomains_ctg447_2_PCP.1"
                     /locus_tags="ctg447_2"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       990..1037
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0001"
                     /evalue="2.00E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="ctg447_2"
                     /protein_end="185"
                     /protein_start="169"
                     /score="16.8"
                     /tool="antismash"
                     /translation="GPAVNVQTACSTSLVAV"
     CDS_motif       1413..1460
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0002"
                     /evalue="7.90E-05"
                     /label="PKSI-KS_m5"
                     /locus_tag="ctg447_2"
                     /protein_end="326"
                     /protein_start="310"
                     /score="14.5"
                     /tool="antismash"
                     /translation="YIEAHGTGTKLGDPIEI"
     CDS_motif       1521..1565
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0003"
                     /evalue="4.30E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="ctg447_2"
                     /protein_end="361"
                     /protein_start="346"
                     /score="9.9"
                     /tool="antismash"
                     /translation="GSLKTNMGHLDAAAGV"
     CDS_motif       2073..2129
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0004"
                     /evalue="1.30E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ctg447_2"
                     /protein_end="549"
                     /protein_start="530"
                     /score="20.6"
                     /tool="antismash"
                     /translation="VFMFPGQGSQYVNMALELYE"
     aSDomain        2079..2966
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg447_2_PKS_AT.1"
                     /evalue="2.00E-102"
                     /label="ctg447_2_PKS_AT.1"
                     /locus_tag="ctg447_2"
                     /protein_end="828"
                     /protein_start="532"
                     /score="334.3"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="consensus: mal"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="MFPGQGSQYVNMALELYETESLFREQVDFCAEILKPELELDLRQI
                     LYPQPEKIQVAEQQLQQTAIAQVAIFVVEYALAKLWQSWGVSPQAMIGHSIGEYVAATL
                     AGVFSLEAALCLVAARGKMMQQLPGGTMLSIPVSAEEVKPLLTAEISIAAINEPSRCVA
                     SGSTEAIEILESKLASQSIECRRLHTSHGFHSQMMEPILDKFKQRVEQESLKAPQIPYI
                     SNLTGDWITEAQAKDANYWVQHLRQTVLFAQGIENILSNPEQVLLEVGPGRTLTSLTKR
                     HPAHNKEQLVLTSVRH"
     CDS_motif       2268..2327
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0005"
                     /evalue="5.10E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ctg447_2"
                     /protein_end="615"
                     /protein_start="595"
                     /score="10.2"
                     /tool="antismash"
                     /translation="AIAQVAIFVVEYALAKLWQSW"
     CDS_motif       2331..2453
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0006"
                     /evalue="4.70E-25"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ctg447_2"
                     /protein_end="657"
                     /protein_start="616"
                     /score="80.0"
                     /tool="antismash"
                     /translation="GVSPQAMIGHSIGEYVAATLAGVFSLEAALCLVAARGKMMQQ"
     CDS_motif       2535..2573
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0007"
                     /evalue="7.80E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="ctg447_2"
                     /protein_end="697"
                     /protein_start="684"
                     /score="12.7"
                     /tool="antismash"
                     /translation="AAINEPSRCVASGS"
     CDS_motif       2727..2759
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0008"
                     /evalue="3.00E-03"
                     /label="PKSI-AT-M_m7"
                     /locus_tag="ctg447_2"
                     /protein_end="759"
                     /protein_start="748"
                     /score="10.3"
                     /tool="antismash"
                     /translation="PQIPYISNLTGD"
     CDS_motif       2796..2831
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0009"
                     /evalue="2.70E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="ctg447_2"
                     /protein_end="783"
                     /protein_start="771"
                     /score="14.4"
                     /tool="antismash"
                     /translation="YWVQHLRQTVLFA"
     aSDomain        3966..4559
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg447_2_PKS_KR.1"
                     /evalue="2.00E-50"
                     /label="ctg447_2_PKS_KR.1"
                     /locus_tag="ctg447_2"
                     /protein_end="1359"
                     /protein_start="1161"
                     /score="163.0"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="GTYLITGGLGNIGMLLAEYLAKNFSANLILIGRSTFPDRDSWSEW
                     LDKHNEQDTISRKIRKFKELEALGAKILVESADVSNLQEMQSVIEKAENKFGVINGVIH
                     AAAVVEDSPIEKTSKAECKQQFLSKVSGVLVLEKLLANKNLDFCLLMSSLLSILGGLGF
                     VTYGASNSFLDSFVNARSHKENNFPWITVNWDDWEV"
     CDS_motif       3969..4067
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0010"
                     /evalue="2.20E-12"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg447_2"
                     /protein_end="1195"
                     /protein_start="1162"
                     /score="39.6"
                     /tool="antismash"
                     /translation="TYLITGGLGNIGMLLAEYLAKNFSANLILIGRST"
     CDS_motif       4398..4505
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg447_2_0011"
                     /evalue="1.90E-09"
                     /label="PKSI-KR_m4"
                     /locus_tag="ctg447_2"
                     /protein_end="1341"
                     /protein_start="1305"
                     /score="30.0"
                     /tool="antismash"
                     /translation="LDFCLLMSSLLSILGGLGFVTYGASNSFLDSFVNARS"
     aSDomain        4857..5060
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg447_2_PCP.1"
                     /evalue="1.30E-19"
                     /label="ctg447_2_PCP.1"
                     /locus_tag="ctg447_2"
                     /protein_end="1526"
                     /protein_start="1458"
                     /score="61.9"
                     /tool="antismash"
                     /translation="EKIIEIFQSLLGNTNIGINDDFFELGGDSLIGTMLIAKVKQEFKI
                     NINLSDVFNLTTVAQISEHITNQQ"
     CDS             5216..5536
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg447_3"
                     /sec_met_domain="Condensation (E-value: 1.7e-19, bitscore:
                     57.6, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLTQIEQQEIAKKLTKLSDEKRLALIELLRKEGIDSLKLPIVPT
                     IRKSNNLPSSWAQERLWFLNQFQGKSATYNMPLALRISGNLDINALQQAASQIVQRHEV
                     LRT"
ORIGIN
        1 gattacatgg tacctagtgc ctttgtcacc ttagacagct taccattaac acctaacggt
       61 aaaattgacc gcaaagcatt accaacatcg gatataaact taacccgttc tcatgaatat
      121 gttccacctc aaactgaaac tgaaaaacat attgcagggg tattacaaga agtactgcaa
      181 ctagaaaaag tgagcattaa tgacaactta tttgagctag gagctaattc attaacatta
      241 gtaactatca acattaaatt acggcaaata ttatcaatag aactccctct tgttgatatg
      301 tttacatacc caaatataaa aactttaagc caacatatag taaatattaa taatccagaa
      361 tcgttgataa aagaacaatt attaagccgt agacaaatta aatcgagtat gaagaaaaga
      421 cgtaaattga gagaaaaact ttaagatatc acttcactaa aatcaattga ggacagaaaa
      481 ttatgaacga cattaatgat ttagatattg caattattgg gctatcaggt cgctttcctc
      541 aagcaaaaaa tattgattct ttctggaaaa atataaaaaa tggtgtggaa tctattcatt
      601 ttttctcgga agaagagtta ttagaggaag gtattagctc taatttgcta aaaaatccca
      661 attatgtaaa agctaaagcg gtacttgcgg atgttgagat gttcgatgcc aatttttttg
      721 gttttagttc taaggaagcc aagcttatcg atccacaaca acgtctgttt ctagaatctg
      781 cttgggaagt gattgaaagt gctggttatg acccagaaaa atacagtggc tcgattggag
      841 tatatgcagg tacgagttca aatacttact tgttgaacaa tatctatccc aagtttgatg
      901 cggaagattt tgctggcata tatcaattaa tgctgagcag caacaaagat ttccttccta
      961 ctcgcgttag ttataaattg aatctcaagg gaccagcagt taatgtgcaa actgcttgtt
     1021 caacttcatt agtagcagtt cacatcgctt gtcaaagttt gctcaatgga gaatgcgaca
     1081 tggctttagc tggtggggtt tcaatttcta tcccccagaa gactggttat ctgtattctg
     1141 aagggatgat tgcttctcca gacggtcatt gtcgagcgtt tgatgcgaag gctgagggta
     1201 ctttaggaag cagtggtttg ggtattgtac ttctgaaacg gctggaagat gcgatcgcgg
     1261 ataaagattg tattcatgct gtcattaaag gttcggctat caataatgat ggttctgtga
     1321 aagttggttt tacagcacca agtactgaag gtcaagcagc agtgattgct caagctcaag
     1381 ctgttgctga ggtagatgca gagagtatca cttatattga agctcacggt accggtacaa
     1441 aattaggtga cccgattgaa attgctgctt taactaaagc atttagaaag agtacggata
     1501 aaaagcaatt ttgtgctgtt ggttctctca aaactaacat gggacatctt gatgctgctg
     1561 cgggtgtggg aggtttacta aaaacagttt tagctttgaa acataaggta attcccccca
     1621 gtttacattt tgaagaacca tcccccaata ttgattttgc taacagtccg ttttatgtaa
     1681 atactgcttt gtctgaatgg aatagcaatg gtaatcctcg acgagcaggg gttagttctt
     1741 tcggtattgg tggtactaat gctcatgtaa ttttagaaga agctccccca cttccagcat
     1801 caggagattc tcgaaaacaa catttacttc tgatatctgc aaaaactatc tctgcgttgg
     1861 agcaagcgac tgctaatttg ggtaaatatc tgcaagaaaa tcctgacaca aatttggctg
     1921 atgttgctta cactttgagt tgcggacgta gaaattttgt acatcgacgg atgttggttt
     1981 gtcagtcaac tgaagatgcg gtaactgtat taggtgatgt tgattcccaa aacattttta
     2041 ccaatactgt gggagctaca gataaaccag ttgtcttcat gtttcctgga cagggttccc
     2101 aatatgtgaa tatggcattg gaactctacg aaaccgaatc tttatttcgg gaacaggtag
     2161 atttttgtgc ggaaatatta aagccggaat tagaattaga cctacgtcaa atactttatc
     2221 cccaaccgga aaaaattcaa gtagcagagc aacagttgca gcaaacagcc attgctcagg
     2281 ttgctatttt tgttgtggag tatgctttag ctaaattatg gcaatcttgg ggcgtttctc
     2341 ctcaagcaat gattggtcat agtataggtg aatatgttgc tgcaacttta gcgggggtat
     2401 tttccttgga agctgcttta tgtttggttg ctgctagggg aaaaatgatg cagcaattac
     2461 cgggtggtac gatgctttcc attcccgttt cagcagagga agttaaacct ttactaacag
     2521 cagaaatttc catagctgca attaacgagc cttctcgatg tgtagcttct ggttctacag
     2581 aagcaattga aattctggaa agtaaattag cttctcaaag catagaatgt cgtcgtctac
     2641 atacttctca tgggtttcac tctcaaatga tggaaccaat tttagataaa tttaaacaaa
     2701 gggttgaaca agaatcatta aaagctcctc aaatccctta tatatctaat ttaaccggag
     2761 attggattac agaagctcaa gcaaaagatg caaattattg ggttcagcat ttacgtcaaa
     2821 ctgttctttt tgctcaggga atagagaata tattatcaaa cccggagcaa gttttattgg
     2881 aagtaggtcc cggtagaacg ttaacttctt taactaaacg tcatccggct cataataaag
     2941 aacaattagt attaacatcg gtacgtcatc ccaaggaaga taaatcagat atagcttgtt
     3001 tgctaacaac agtaggtaat ctgtggttag ctggagttaa tgtagattgg ttagcatttt
     3061 attcgcaaga ggagcgttat cgagtacctt taccaactta tccttttgaa cgtcagcgtt
     3121 attggatttc tccaccaaca ctggaagaaa aagtaaaaag taagaagcaa gaaataagta
     3181 aacaagaaat aagtaaaact tcagatattt ctcaatggtt ttatgttcct tcctggaaac
     3241 gggttccttt agcacctagt caattaaaaa aatcaccggg tcatatttta ttgtttgtag
     3301 atgagtatgg tttaggagaa aaattaactg ttcaactgac acaaatggat gaaaaagtaa
     3361 tttgtgtcca agtgggagat tcatttacaa aacagagtga aggtgtttat actgtcaatc
     3421 ctcaacaagc tgatgattac aatactcttg taaatgaact tgtgaaactg gatataattc
     3481 ctaaacaagt gattcattta tggagtttga ctaaagaaaa ttcagaagca agtttaagag
     3541 taaatttaga ttatgaagta tttgataaag ctcaagattt aggattttat agtctattat
     3601 ttattgtcca agctcttggt aaacaagctt cggtagatac atgtgaattt tctgttattt
     3661 ctaataaatt atttgatgtg attggagagg atgaattgtc tcctgaaaaa actactttac
     3721 taggaccgat acgaacaatt tatcaggagt attttaactt taattgtcgt tgcattgatg
     3781 tgattttgcc acagtctgaa actaggaaag agaagatatt catagataat ttaattgcag
     3841 aattaactac agcaagcaac gaacaaataa ttgcctatcg tggtaaatct cgttggatag
     3901 aaagttttga gtcatttaca ctacaacctc aagttaattc tgggaaacaa aatttaaaac
     3961 agcaagggac ttatctgatt acaggtggat taggtaatat tggaatgcta ttagctgagt
     4021 atttagccaa gaatttcagt gctaacttga ttttaattgg acgctctact ttcccagata
     4081 gagatagttg gtcggagtgg cttgataagc ataacgaaca agatacaatt agccggaaaa
     4141 ttcgtaaatt caaagagctt gaagcgttag gagcaaaaat tttagtcgag agtgctgatg
     4201 tttctaattt acaagaaatg caatcggtaa ttgaaaaagc tgagaataaa tttggtgtaa
     4261 ttaatggagt aattcatgct gctgctgtgg ttgaagatag cccaattgaa aagactagta
     4321 aagcagagtg taagcagcaa tttttatcta aagtaagtgg tgtactggta ctggaaaaat
     4381 tattagcaaa taagaattta gatttttgtt tgttaatgtc tagtttatta tctattttgg
     4441 gaggattggg atttgttacc tatggggcta gtaatagctt tttagattct tttgttaatg
     4501 cacgtagtca taaagaaaat aatttccctt ggataactgt taattgggat gattgggaag
     4561 ttgataaaga agaaacacaa aatcaaggct tagataagaa attaagaacg ttagcaatta
     4621 atccagaaga aggaataaaa gcttttgaat taattctatc tggaataaat tttctatctg
     4681 gattaaatac taatcagata gttgtttcta cgagcgattt agaattaaga gtcaacaaat
     4741 tggcaaagtg taatagcttg aaaggtaaaa ataatttaga aaaatactca gattctcaag
     4801 ctagtaatca aagaaatgtt actaatgctt atgtgcctcc tcgaaatgaa atagatgaaa
     4861 agattataga gatttttcaa tctcttcttg gcaataccaa catcggtatc aatgatgatt
     4921 tttttgagtt aggaggagat tcattaatcg gaactatgct gatagcaaaa gtcaagcaag
     4981 aatttaaaat caatatcaac ctcagtgatg ttttcaattt aaccactgtt gctcagattt
     5041 ctgaacatat tacgaatcaa caacaatctt cacagaatga cttaaagagg attagtgaaa
     5101 tattagaaat agttgatatt atgccagatt aatagactaa ttaaaagtca aaatatgacc
     5161 tgggttcatg caggatataa atcaaaattc atacgccaaa aaataagagt aaatcatgaa
     5221 attaactcaa atagaacaac aagaaatcgc caaaaaactt acaaaacttt ccgatgaaaa
     5281 acgtcttgca cttatagagt tactccgcaa ggaaggaatc gattcactta aattacctat
     5341 tgttcctact attagaaaat caaacaattt gccatcatcc tgggcacaag agcggctatg
     5401 gtttctcaac caattccaag gaaaaagtgc cacttacaat atgccattag ccctccgcat
     5461 cagtgggaac ttggatatta atgctctaca acaagctgct tcacaaatag tacagcgcca
     5521 cgaagtacta cgcaccag
//
