LOCUS       c00587_3300002..        6701 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300002858.a:JGI1201J43222_100514.
ACCESSION   c00587_3300002..
VERSION     c00587_3300002..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 04:47:05
            Original ID  :: 3300002858.a:JGI1201J43222_100514
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6701
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6701
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:5243](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..5243
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..6701
                     /SMILES="NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6701
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             3..5243
                     /NRPS_PKS="Domain: PCP (242-309). E-value: 6.2e-28. Score:
                     88.6. Matches aSDomain: nrpspksdomains_ctg587_1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (331-637). E-value:
                     4.5e-125. Score: 408.3. Matches aSDomain:
                     nrpspksdomains_ctg587_1_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (802-1239). E-value: 2e-105.
                     Score: 344.4. Matches aSDomain:
                     nrpspksdomains_ctg587_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1388-1457). E-value: 1.7e-26.
                     Score: 84.0. Matches aSDomain:
                     nrpspksdomains_ctg587_1_PCP.2"
                     /NRPS_PKS="Domain: Thioesterase (1476-1738). E-value:
                     2.2e-39. Score: 127.9. Matches aSDomain:
                     nrpspksdomains_ctg587_1_Thioesterase.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     455.4; E-value: 4e-138)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg587_1"
                     /sec_met_domain="Condensation (E-value: 8.6e-93, bitscore:
                     298.3, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.9e-118, bitscore:
                     382.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.5e-19, bitscore:
                     57.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PQKLLHLYGPAESTTLASWYLVKSVSPNATNLPIGKPISNTQIYI
                     LDRQLQPVPIGVPGELYIGGDGLAREYLNRPELTAEKFIVQTRHNVETLHATSLQGLRL
                     YKTGDLAKYLPDGNIEYLGRIDNQVKIRGFRVELGEIEAVLSQHSGVRESVIATQKDTL
                     GNQSLVAYVTLLQQSLNLDDLRSFLIAKLPEYMVPSAFVELETLPLTPNGKVNRSALPT
                     PDITAFTRSNQFIAPHTPTQELLATIWAEVLGLKQIGIHDNFFALGGHSLLATQLISRV
                     REAFCVEIPLSSLFTNPTIEQLSLAIETEHQIDSGLKLTAIEPVDREEINTHLPLSFAQ
                     QRLWFLHQLEGSSAAYNMPAAVKLNGNLEISALEQALTEIVQRHEVLRTSFKVVNGSPV
                     QVINPNQSLSLPLINLQHLPENEKTAEVKRLAIAESQQPFDLSKSPLLRATIVQLGNES
                     HVLLLTMHHIASDGWSIGIFIQELSTLYQALSQGKPLSTATQSLAPLPIQYADFAHWQR
                     KWLTGEVWENQLKYWKQQLADAPQILELPTDRPRPPVQTFRGSTHQFELDRKLTQQLKT
                     LSQSSGTTLFMTLFAGFAILLSRYSNQKDIAIGSPIANRNHREVESLIGFFVNTLILRT
                     NLEDNPSFSDLLTQVRQVALDAYAHQDLPFEKLVEELQSGRNLDRNPLVQIVFTLQNGS
                     TSSWELENLSLTQLELDYQTVRFDLEVHLWEVGEQLDGYLVYNTDLFNKTTITQIANNF
                     QTLLKAIVADPEQQVFSLPLLTVDERHQLLNRWNDTEINYPQDRCVHQLFEKQVEQNPR
                     AVAVVCEEQQLSYEELNTRSNQLAHYLQSLGVGAETLVGICVERSLDTIVGILAILKAG
                     GAYVPLDPSYPKARLGYMLSDSQVSVLLTQQKLVPELPDYQGKLICLDTDWESISQASK
                     ENLVVNITPENSAYVIYTSGSTGKPKGVLITHKNLLNLIFWHQETFAITSSDRATQLAG
                     NAFDASVWEIWPYLTVGASLYLVKPELLKSALNLQQRLIDQKIAIAFVPTPLAEELFSL
                     EWPQNTALRTMLIGGDRLHQYPANTLPFQVINNYGPTENTVVTTSGLVVNPNLGKTSPH
                     NISPPIGRPIANTQVYILDEYLQPLPIGVPGELCISGASLARGYLNRPELTAEKFITNP
                     FIETLQRLNADAAGSVRSLHGASVQKPIASPQSPIASRKSPTPKLYKTGDRARYLPDGN
                     IEFLGRIDHQVTLRGFRVELGEIESVLLQHPGVQNVIVEMRHARMHHERLDPTSPQEDK
                     RLVAYIVPNTENQSLQTQLNQPQTEYTSHKGTPYEETYSRSPQLIPKLRNYLKQTLPHY
                     MVPSAFVMLSALPLTSNGKIDRKALPTPETDNNREIPFVAPRDRLESELAQIWSEILDV
                     RLIGVRDNFFDLGGHSLLSVRLMDRVKQKFAKNLSLATLFQNPTIEHLADFLRQETESL
                     PHSPLVPINSGGSKQPFFCVPGAGGNVIYFYDLVRHLSPEQPFYGLQALGLDGISQPLT
                     NIADIATYYIKAIQTVQPQGPYLLGGHSFGAKIAFEISQQLQSQGHEVSLLAIFDAPTP
                     LFSDRPVGVDWDDVEWFSQIASVIERLLGEKLQVSTEVLQSLTLEQQFNYFHQQLQTVN
                     LLPSGEVGKQQARGLVRVYQASCQANYELPKKIYPTKILLFRANESNFAETQSQEFSQE
                     FSQTLADPTWGWKEFSSQPVDIYTIPGDHITMMSEPHVRILAKYLGQTL"
     CDS_motif       24..47
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0001"
                     /evalue="1.40E+00"
                     /label="NRPS-A_a5"
                     /locus_tag="ctg587_1"
                     /protein_end="15"
                     /protein_start="7"
                     /score="2.7"
                     /tool="antismash"
                     /translation="YGPAESTTL"
     CDS_motif       162..251
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0002"
                     /evalue="1.10E-18"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg587_1"
                     /protein_end="83"
                     /protein_start="53"
                     /score="59.3"
                     /tool="antismash"
                     /translation="PIGVPGELYIGGDGLAREYLNRPELTAEKFI"
     CDS_motif       363..428
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0003"
                     /evalue="2.00E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg587_1"
                     /protein_end="142"
                     /protein_start="120"
                     /score="38.9"
                     /tool="antismash"
                     /translation="YLGRIDNQVKIRGFRVELGEIEA"
     CDS_motif       639..665
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0004"
                     /evalue="2.30E+00"
                     /label="NRPS-A_a10"
                     /locus_tag="ctg587_1"
                     /protein_end="221"
                     /protein_start="212"
                     /score="2.1"
                     /tool="antismash"
                     /translation="GKVNRSALPT"
     aSDomain        729..929
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg587_1_PCP.1"
                     /evalue="6.20E-28"
                     /label="ctg587_1_PCP.1"
                     /locus_tag="ctg587_1"
                     /protein_end="309"
                     /protein_start="242"
                     /score="88.6"
                     /tool="antismash"
                     /translation="ELLATIWAEVLGLKQIGIHDNFFALGGHSLLATQLISRVREAFCV
                     EIPLSSLFTNPTIEQLSLAIETE"
     aSModule        729..929
                     /domains="nrpspksdomains_ctg587_1_PCP.1"
                     /incomplete
                     /locus_tags="ctg587_1"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        996..1913
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg587_1_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="4.50E-125"
                     /label="ctg587_1_Condensation_LCL.1"
                     /locus_tag="ctg587_1"
                     /protein_end="637"
                     /protein_start="331"
                     /score="408.3"
                     /tool="antismash"
                     /translation="THLPLSFAQQRLWFLHQLEGSSAAYNMPAAVKLNGNLEISALEQA
                     LTEIVQRHEVLRTSFKVVNGSPVQVINPNQSLSLPLINLQHLPENEKTAEVKRLAIAES
                     QQPFDLSKSPLLRATIVQLGNESHVLLLTMHHIASDGWSIGIFIQELSTLYQALSQGKP
                     LSTATQSLAPLPIQYADFAHWQRKWLTGEVWENQLKYWKQQLADAPQILELPTDRPRPP
                     VQTFRGSTHQFELDRKLTQQLKTLSQSSGTTLFMTLFAGFAILLSRYSNQKDIAIGSPI
                     ANRNHREVESLIGFFVNTLILRTNLE"
     aSModule        996..5216
                     /complete
                     /domains="nrpspksdomains_ctg587_1_Condensation_LCL.1"
                     /domains="nrpspksdomains_ctg587_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg587_1_PCP.2"
                     /domains="nrpspksdomains_ctg587_1_Thioesterase.1"
                     /final_module
                     /locus_tags="ctg587_1"
                     /monomer_pairings="leu -> leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1011..1043
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0005"
                     /evalue="2.70E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="ctg587_1"
                     /protein_end="347"
                     /protein_start="336"
                     /score="10.3"
                     /tool="antismash"
                     /translation="SFAQQRLWFLHQ"
     CDS_motif       1062..1175
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0006"
                     /evalue="1.20E-19"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg587_1"
                     /protein_end="391"
                     /protein_start="353"
                     /score="62.7"
                     /tool="antismash"
                     /translation="AAYNMPAAVKLNGNLEISALEQALTEIVQRHEVLRTSFK"
     CDS_motif       1395..1460
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0007"
                     /evalue="8.50E-13"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg587_1"
                     /protein_end="486"
                     /protein_start="464"
                     /score="40.6"
                     /tool="antismash"
                     /translation="MHHIASDGWSIGIFIQELSTLYQ"
     CDS_motif       1524..1562
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0008"
                     /evalue="2.70E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="ctg587_1"
                     /protein_end="520"
                     /protein_start="507"
                     /score="19.7"
                     /tool="antismash"
                     /translation="QYADFAHWQRKWLT"
     CDS_motif       1815..1904
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0009"
                     /evalue="4.30E-16"
                     /label="C5_LCL_267-296"
                     /locus_tag="ctg587_1"
                     /protein_end="634"
                     /protein_start="604"
                     /score="51.2"
                     /tool="antismash"
                     /translation="DIAIGSPIANRNHREVESLIGFFVNTLILRT"
     CDS_motif       1953..2072
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0010"
                     /evalue="1.80E-22"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg587_1"
                     /protein_end="690"
                     /protein_start="650"
                     /score="71.8"
                     /tool="antismash"
                     /translation="RQVALDAYAHQDLPFEKLVEELQSGRNLDRNPLVQIVFTLQ"
     aSDomain        2409..3719
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg587_1_AMP-binding.1"
                     /evalue="2.00E-105"
                     /label="ctg587_1_AMP-binding.1"
                     /locus_tag="ctg587_1"
                     /protein_end="1239"
                     /protein_start="802"
                     /score="344.4"
                     /specificity="consensus: leu"
                     /tool="antismash"
                     /translation="FEKQVEQNPRAVAVVCEEQQLSYEELNTRSNQLAHYLQSLGVGAE
                     TLVGICVERSLDTIVGILAILKAGGAYVPLDPSYPKARLGYMLSDSQVSVLLTQQKLVP
                     ELPDYQGKLICLDTDWESISQASKENLVVNITPENSAYVIYTSGSTGKPKGVLITHKNL
                     LNLIFWHQETFAITSSDRATQLAGNAFDASVWEIWPYLTVGASLYLVKPELLKSALNLQ
                     QRLIDQKIAIAFVPTPLAEELFSLEWPQNTALRTMLIGGDRLHQYPANTLPFQVINNYG
                     PTENTVVTTSGLVVNPNLGKTSPHNISPPIGRPIANTQVYILDEYLQPLPIGVPGELCI
                     SGASLARGYLNRPELTAEKFITNPFIETLQRLNADAAGSVRSLHGASVQKPIASPQSPI
                     ASRKSPTPKLYKTGDRARYLPDGNIEFLGRIDHQVTLRG"
     CDS_motif       2595..2636
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0011"
                     /evalue="3.30E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg587_1"
                     /protein_end="878"
                     /protein_start="864"
                     /score="20.1"
                     /tool="antismash"
                     /translation="LAILKAGGAYVPLDP"
     CDS_motif       2829..2888
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0012"
                     /evalue="8.30E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg587_1"
                     /protein_end="962"
                     /protein_start="942"
                     /score="33.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVLITHK"
     CDS_motif       3243..3275
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0013"
                     /evalue="5.50E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="ctg587_1"
                     /protein_end="1091"
                     /protein_start="1080"
                     /score="9.5"
                     /tool="antismash"
                     /translation="NYGPTENTVVTT"
     CDS_motif       3399..3488
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0014"
                     /evalue="9.10E-19"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg587_1"
                     /protein_end="1162"
                     /protein_start="1132"
                     /score="59.5"
                     /tool="antismash"
                     /translation="PIGVPGELCISGASLARGYLNRPELTAEKFI"
     CDS_motif       3684..3749
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0015"
                     /evalue="6.70E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg587_1"
                     /protein_end="1249"
                     /protein_start="1227"
                     /score="34.2"
                     /tool="antismash"
                     /translation="FLGRIDHQVTLRGFRVELGEIES"
     CDS_motif       4083..4109
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0016"
                     /evalue="9.30E-02"
                     /label="NRPS-A_a10"
                     /locus_tag="ctg587_1"
                     /protein_end="1369"
                     /protein_start="1360"
                     /score="5.7"
                     /tool="antismash"
                     /translation="GKIDRKALPT"
     aSDomain        4167..4373
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg587_1_PCP.2"
                     /evalue="1.70E-26"
                     /label="ctg587_1_PCP.2"
                     /locus_tag="ctg587_1"
                     /protein_end="1457"
                     /protein_start="1388"
                     /score="84.0"
                     /tool="antismash"
                     /translation="ESELAQIWSEILDVRLIGVRDNFFDLGGHSLLSVRLMDRVKQKFA
                     KNLSLATLFQNPTIEHLADFLRQET"
     aSDomain        4431..5216
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg587_1_Thioesterase.1"
                     /evalue="2.20E-39"
                     /label="ctg587_1_Thioesterase.1"
                     /locus_tag="ctg587_1"
                     /protein_end="1738"
                     /protein_start="1476"
                     /score="127.9"
                     /tool="antismash"
                     /translation="PFFCVPGAGGNVIYFYDLVRHLSPEQPFYGLQALGLDGISQPLTN
                     IADIATYYIKAIQTVQPQGPYLLGGHSFGAKIAFEISQQLQSQGHEVSLLAIFDAPTPL
                     FSDRPVGVDWDDVEWFSQIASVIERLLGEKLQVSTEVLQSLTLEQQFNYFHQQLQTVNL
                     LPSGEVGKQQARGLVRVYQASCQANYELPKKIYPTKILLFRANESNFAETQSQEFSQEF
                     SQTLADPTWGWKEFSSQPVDIYTIPGDHITMMSEPHVRILA"
     CDS_motif       4611..4685
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg587_1_0017"
                     /evalue="2.60E-12"
                     /label="NRPS-te1"
                     /locus_tag="ctg587_1"
                     /protein_end="1561"
                     /protein_start="1536"
                     /score="39.1"
                     /tool="antismash"
                     /translation="QPQGPYLLGGHSFGAKIAFEISQQLQ"
     CDS             complement(5251..5724)
                     /locus_tag="ctg587_2"
                     /transl_table=11
                     /translation="MRIYRSQDRDSIIQMIDSIYKEYGDFIYLEGYDRDLLDIENNYFS
                     NGNFWVETANNDDNKIIGSIAVKKELDYEDTALMKRFYLLPQYRGLGLAETLHDTVINW
                     CKKNQISKLHLWSDTRFTRAHFFYQKNGYERGEMIDRNDGAMPYQEYYFMKLL"
     CDS             5873..6418
                     /locus_tag="ctg587_3"
                     /transl_table=11
                     /translation="MKNQYKSFFFAVLKKQYSSPRFYLTTLLIPVVLGSLWILGNSSSK
                     TCACVPMFKEAQTYLGVMNRAQQALYLEKKLFASSLNELNNLQKLDLISETGHYRYSIQ
                     PTKLGTFHYAIPIKKAGRKLPYHTSYIAGVFVSQDSDKRSKTSTIICEVNTPDSHPLPQ
                     PKLKNNVPTCPTGTSLVK"
ORIGIN
        1 ctccccaaaa attattacac ctctatggtc cggcagaaag tacaacactt gctagctggt
       61 atttagtaaa atcggtttcc ccaaatgcaa ctaaccttcc catcggaaaa ccaattagca
      121 acacccaaat ctatattctc gaccgtcagt tgcaaccagt acctatcggc gtacctgggg
      181 aattatacat cggtggagac ggtttagccc gagaatacct caaccgtcca gaactaaccg
      241 cagaaaaatt tattgtacag acgcgccata atgtagagac gttgcatgca acgtctctac
      301 agggtttgcg attatacaaa acaggggatt tagcaaaata tctccctgac ggtaatattg
      361 aatatcttgg tcgaattgat aatcaagtca aaattcgcgg tttccgggtc gaactgggtg
      421 aaattgaagc agtcctgagc cagcattctg gggtacgcga atctgtaatt gcaactcaaa
      481 aagatactct tggtaatcaa tctttggtag cttatgtgac tttgctgcaa caatcgctga
      541 atctcgatga cttacgaagc tttctcatag caaaactacc cgagtacatg gttccttcgg
      601 cgtttgtaga attagaaaca ctaccattaa caccaaacgg taaagtaaat cgctccgctt
      661 taccaactcc agacataaca gcttttaccc gttcaaatca atttattgct ccccataccc
      721 caacccaaga acttctagcg accatttggg ctgaagttct aggactaaaa caaataggta
      781 tccacgacaa tttttttgct ttgggaggtc attctttact tgctacccaa cttatttctc
      841 gggtgcggga ggctttctgt gtagaaatac cactcagtag tttatttacg aaccccacca
      901 tcgaacagct gagtttagca attgagacag aacaccagat agactcaggg ctaaaactta
      961 cagccatcga accggttgat cgagaagaga taaatacaca tctaccctta tcttttgctc
     1021 aacaacgact gtggtttctc catcaacttg aagggtcaag tgctgcttat aacatgccag
     1081 ctgctgttaa attaaatggt aatctggaaa tttcagcctt agagcaagcc ttaacagaaa
     1141 ttgtccagcg tcacgaagtt ttacgtacca gttttaaagt agttaatggc tctcccgtac
     1201 aagttattaa ccccaatcaa agtttatctt taccactaat aaacctacag catttaccag
     1261 aaaacgaaaa aactgctgaa gtaaaacggt tagcgatcgc cgaatctcaa caaccctttg
     1321 acttaagcaa aagtccttta ctccgagcta ccattgtgca actggggaat gaatctcatg
     1381 tgctattgtt aacaatgcac cacattgcat ctgatggctg gtcaataggt atatttattc
     1441 aagaattatc caccctttat caagctttat ctcaaggaaa accattatct acagccacgc
     1501 aatcccttgc acccttacca attcaatatg ctgacttcgc ccattggcaa cgaaaatggt
     1561 taactggaga agtatgggaa aatcaactca aatactggaa gcaacaactc gcagacgcac
     1621 cgcagatttt agaactaccg actgaccgtc cgcgaccccc agtgcaaact tttcgcggta
     1681 gcacccacca atttgaactt gatcgcaaac tgacccaaca attaaaaact ctcagtcaaa
     1741 gttcagggac aaccttgttt atgactttgt ttgcagggtt tgcaatctta ctttcccgtt
     1801 acagtaacca aaaagatatt gctattggtt ccccgatcgc aaaccgtaat catcgtgaag
     1861 tagaatcatt aattggcttt tttgtcaata ctttaatttt gcgtactaac cttgaggata
     1921 atcctagctt ctcggattta ctaactcaag ttcgccaggt cgctttagac gcttacgctc
     1981 accaagattt accttttgag aaactagtag aagaattaca gtccggacga aatttagatc
     2041 gcaaccccct cgtacaaata gtctttactc tccagaatgg atctacaagt tcttgggaac
     2101 tggaaaatct cagcttgacc caattagaat tggattatca aacggttaga ttcgatctag
     2161 aagtacattt atgggaagta ggagaacaac tcgatggcta tcttgtttac aatacagact
     2221 tgtttaataa aactactatt acccaaatag caaataactt ccaaacctta cttaaagcaa
     2281 ttgtcgccga ccccgaacaa caagttttct cattacctct gttaaccgta gacgaacgac
     2341 atcaattact aaatcgatgg aacgacaccg aaattaacta tcctcaagat agatgcgttc
     2401 atcaattatt tgagaaacaa gtagagcaaa atccccgcgc agtagctgta gtctgtgaag
     2461 aacaacaact aagctatgaa gaattaaaca cccgcagcaa tcaactagcc cattacttgc
     2521 aatctctggg agtaggagca gaaacattag taggaatttg tgtcgagcgc tccttagata
     2581 ccattgtcgg aatattagca attctcaaag ctggtggtgc ttatgtcccg ttggatccga
     2641 gttatccaaa agcacgtctt gggtatatgt tgtcagattc tcaggtatcg gtactattaa
     2701 ctcaacaaaa attagtacct gaacttcccg actatcaggg taagttaatc tgtttagata
     2761 cagactggga atcgatttct caagcaagca aagagaactt agttgttaat attactcctg
     2821 aaaactcagc ctatgtaatt tacacatccg gttctaccgg aaaacctaaa ggagtattaa
     2881 tcacccataa aaacctgtta aacttaatat tctggcatca agaaaccttt gcaattactt
     2941 cctcagatcg agctactcaa ttagcaggaa atgcatttga tgcttcagta tgggaaatat
     3001 ggccttattt aacagtagga gcaagtcttt acctagtcaa acccgaactt ctcaaatctg
     3061 cactgaattt acaacagcgg ttaatagacc aaaaaattgc gatcgcattt gtacctacac
     3121 ccctagcaga agaattattt tctttagaat ggccccaaaa cacagcttta cgaactatgc
     3181 taattggtgg cgatcgcctg catcaatacc cagcaaatac ccttcctttc caagtaatta
     3241 acaactacgg acctacagaa aatactgtag taacaacttc tgggcttgtg gttaacccta
     3301 atctaggtaa gacctcacca cataatattt caccaccaat tggtcgccca atagccaata
     3361 cccaagttta catattagat gaatacctgc aaccattacc aataggcgtt cctggagaac
     3421 tgtgtatcag tggagcttcc ctagcccgag gttacctcaa ccgtccggaa ctgaccgcag
     3481 aaaaattcat tacaaatccc ttcatagaga cgttgcagag gcttaacgcc gacgccgcag
     3541 gctctgtgag gtctctacat ggcgcgtctg tgcaaaagcc aatcgccagt ccccaatccc
     3601 caatcgccag tcgcaaatcc ccaaccccca aactctacaa aacaggtgat cgtgctcgct
     3661 atctcccaga tgggaatatt gaatttctcg gtcgtattga ccatcaagtg acacttcgcg
     3721 gctttcgagt tgaactcgga gaaattgaat ctgtattatt gcaacatcct ggggtacaaa
     3781 acgtcatcgt agagatgcga catgcacgga tgcaccatga gaggttggat ccaacgtccc
     3841 cacaggaaga taaacgtttg gttgcatata tagttcccaa caccgaaaat caaagtttgc
     3901 aaacccaatt aaatcaacca caaaccgaat atacctccca caagggaaca ccttacgaag
     3961 aaacttatag ccgatcgcct cagttaatac ccaaactacg taattaccta aaacaaacat
     4021 tacctcatta catggtgccc tcggcatttg taatgctatc tgctttacca ttaacctcca
     4081 acgggaaaat agatcgaaaa gctctcccca cccccgaaac tgataataat cgagaaattc
     4141 cctttgttgc tccccgcgat cgcttggaat cagagctagc gcaaatttgg tcagaaattc
     4201 tcgatgttcg attgatagga gtgcgcgata acttcttcga ccttgggggt cattccctat
     4261 tatccgtccg tttaatggat cgagtaaagc aaaaatttgc caaaaatcta tccctagcaa
     4321 cacttttcca aaatcccacc atcgaacatt tggctgactt tctccgtcaa gaaactgaat
     4381 ctttacccca ctctccctta gtcccaatta attcaggtgg ttcaaaacaa ccattctttt
     4441 gcgtacccgg agcgggcggt aatgtaattt acttttatga cttagtgcgc catttgagtc
     4501 cagagcaacc attttacgga ctccaagctc tcggacttga cggaatatcc caaccactaa
     4561 ctaatattgc agatatcgcc acctactaca tcaaagccat ccaaaccgtt caaccccaag
     4621 gaccttattt actcggaggt cattccttcg gcgcaaaaat agcctttgaa atatctcaac
     4681 agttacaaag ccagggacat gaggttagtt tactagcaat ttttgatgct ccaacaccct
     4741 tatttagcga tcgccccgtt ggtgttgatt gggatgatgt tgagtggttt tcccaaatcg
     4801 ccagtgtaat cgaacgccta cttggggaaa aactccaagt atccactgaa gttctccaat
     4861 ctcttacact agaacaacag tttaactact ttcatcaaca actacaaaca gttaaccttt
     4921 taccatcagg ggaagtaggt aaacaacaag caaggggtct agtccgagtt tatcaagcaa
     4981 gttgtcaagc aaattacgaa ttaccaaaga aaatttaccc cacgaaaatt ttgctatttc
     5041 gcgccaacga atctaacttc gcagaaacac aatctcaaga attttctcaa gaattttccc
     5101 aaactttagc agatccaact tggggttgga aagaattttc ctcccaaccc gtagatatat
     5161 atacaattcc cggagatcac attaccatga tgagcgaacc tcacgttcga attctggcaa
     5221 aatatttagg acaaactttg tagaaaaaaa tcaaagcaac ttcataaaat aatattcttg
     5281 gtaaggcatc gcaccatcgt ttctatctat catttcacca cgttcataac catttttctg
     5341 ataaaaaaaa tgtgcccgcg tgaatcttgt atccgaccat agatgcaatt tacttatttg
     5401 atttttttta caccaattaa ttaccgtatc gtgcaaagtt tctgccaatc ccaaaccgcg
     5461 atattgtggt agcaaataaa atcttttcat taaagcggta tcttcataat ctaattcttt
     5521 tttaactgca attgaaccaa taattttatt atcatcatta tttgcagttt ccacccaaaa
     5581 attaccatta ctgaaataat tattttctat atctagcaaa tcgcgatcat aaccttctaa
     5641 atatataaaa tcgccatatt ctttataaat tgaatcaatc atttgaataa tactgtctct
     5701 atcttgggaa cgatatattc tcatgatttt taccgttgac aactaattac aaaagttcta
     5761 attactcgta gcaaaatcca cattaagtag aatttgtgat gtttctggac cctattttga
     5821 ttcaaaatag ctaatcagca ttaccaacac ctataaaaaa taatataatc ttatgaaaaa
     5881 tcaatataaa tcattttttt ttgctgtctt aaaaaaacaa tattcttcac cacgctttta
     5941 tttaacaact ttactaatac cagttgtatt aggaagcctc tggattttag gaaatagttc
     6001 ttcaaagacc tgtgcttgcg ttcctatgtt taaagaagca caaacatatt tgggtgtaat
     6061 gaatcgcgct cagcaagctt tatatttaga aaaaaaatta tttgcaagct cgctcaatga
     6121 actgaataat ttacaaaaat tagatcttat tagtgaaact ggacattatc gctactctat
     6181 tcagccaacg aaattaggta catttcatta tgcgattcca atcaagaaag ctggtagaaa
     6241 attaccgtac catacaagtt acattgcagg agtatttgtt tctcaggact ctgataagcg
     6301 ttctaaaact tcaacaatca tatgtgaagt taatactccc gactcacatc cccttcccca
     6361 accgaaactt aaaaataatg ttcctacttg tcctacaggt acatctcttg tgaagtaata
     6421 ctaagtccgg gttagttacc ccttttttga atgagagagg gaagtgtggg aggtgtggga
     6481 agtgtgggaa gtgtagnaag tgtgggggaa atcccaaaaa atatataaat aagcgatcgc
     6541 aaaagtaata ccaaccgacg gcaaataaaa caaaaaatcc aaacaaaaaa tccatttccc
     6601 agattgaagg tgagaaacgg aaccaagaac aaaaaattat tttcgaactg aactaccaat
     6661 taaccattac caaaattaat ttggtttgag ccgctcgcgc c
//
