LOCUS       c00043_3300005..        6852 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300005290.a:Ga0065712_10001218.
ACCESSION   c00043_3300005..
VERSION     c00043_3300005..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 04:55:21
            Original ID  :: 3300005290.a:Ga0065712_10001218
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6852
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..6852
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:6850]"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2..6850
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..6852
                     /SMILES="NC(CC(=O)N)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..6852
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             2..1984
                     /NRPS_PKS="Domain: PCP (112-181). E-value: 9.7e-25. Score:
                     78.3. Matches aSDomain: nrpspksdomains_ctg43_1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (199-500). E-value:
                     1.4e-125. Score: 410.0. Matches aSDomain:
                     nrpspksdomains_ctg43_1_Condensation_LCL.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     480.7; E-value: 8.2e-146)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_1"
                     /sec_met_domain="Condensation (E-value: 1.3e-85, bitscore:
                     274.7, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-19, bitscore:
                     58.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LGEVEASLRNHEWVREAVVVVREEKAGDKRLVAYVVLDQSSAAAA
                     EAEEKWSSPLRQYLKARLPEYMIPAAFVKLAQLPLTANGKVDRRALPAPAMAAVAVAGA
                     EERVLTPSEELVRGIWMEVLGLGQVSVNADFXELGGHSLLATQVISRVREVFGVEVPLR
                     VLFEEPTVAALAQAVEQEQQAARGYRLGSITAVAREQVLPLSFAQQRLWFLAQLEPESA
                     FYNVPLAVRLKGELKLAALEATLSEVVRRHEVLRTTFSVREGEPVQIIHEAERVRLSVE
                     DLSELSEAEREAEAGRRAAAEAQVTFDLEQGPLLRIRVLRLAASEHVVLLTMHHIVSDG
                     WSMGVLVKEVAALYEAYAAGQASPLAELGIQYADFAVWQREWLKGEVLEAQLGYWRRQL
                     AGAPALLELPTDYPRQSIPSYRGALEPLSLPRALSDALKSLSRREGVTLFMTLLAAWQV
                     LLARYSGQEDILVGTPIANRSRAETKDLIGFFVNTLVLRGNLRGDPSFLEVLWRTREVC
                     LNAYTHQDAPFEKLVEEMQPERAANRTPFFQVWFALQNLPVSNVELSDLKMSLLEVPNA
                     TSKFDLTLAVQETGDIIDGALEYDTNLFNSATISRLLNHFERLLRSIVAQPEARISELE
                     ILSEDEYTPLSQVIPIDELNQSFFF"
     aSDomain        338..544
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_1_PCP.1"
                     /evalue="9.70E-25"
                     /label="ctg43_1_PCP.1"
                     /locus_tag="ctg43_1"
                     /protein_end="181"
                     /protein_start="112"
                     /score="78.3"
                     /tool="antismash"
                     /translation="EELVRGIWMEVLGLGQVSVNADFXELGGHSLLATQVISRVREVFG
                     VEVPLRVLFEEPTVAALAQAVEQEQ"
     aSModule        338..544
                     /domains="nrpspksdomains_ctg43_1_PCP.1"
                     /incomplete
                     /locus_tags="ctg43_1"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        599..1501
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_1_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.40E-125"
                     /label="ctg43_1_Condensation_LCL.1"
                     /locus_tag="ctg43_1"
                     /protein_end="500"
                     /protein_start="199"
                     /score="410.0"
                     /tool="antismash"
                     /translation="QVLPLSFAQQRLWFLAQLEPESAFYNVPLAVRLKGELKLAALEAT
                     LSEVVRRHEVLRTTFSVREGEPVQIIHEAERVRLSVEDLSELSEAEREAEAGRRAAAEA
                     QVTFDLEQGPLLRIRVLRLAASEHVVLLTMHHIVSDGWSMGVLVKEVAALYEAYAAGQA
                     SPLAELGIQYADFAVWQREWLKGEVLEAQLGYWRRQLAGAPALLELPTDYPRQSIPSYR
                     GALEPLSLPRALSDALKSLSRREGVTLFMTLLAAWQVLLARYSGQEDILVGTPIANRSR
                     AETKDLIGFFVNTLVLRGNLR"
     aSModule        599..1501
                     /domains="nrpspksdomains_ctg43_1_Condensation_LCL.1"
                     /incomplete
                     /locus_tags="ctg43_1"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       614..643
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_1_0001"
                     /evalue="1.60E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="ctg43_1"
                     /protein_end="214"
                     /protein_start="204"
                     /score="10.9"
                     /tool="antismash"
                     /translation="SFAQQRLWFLA"
     CDS_motif       665..778
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_1_0002"
                     /evalue="1.70E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg43_1"
                     /protein_end="259"
                     /protein_start="221"
                     /score="59.0"
                     /tool="antismash"
                     /translation="AFYNVPLAVRLKGELKLAALEATLSEVVRRHEVLRTTFS"
     CDS_motif       998..1063
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_1_0003"
                     /evalue="1.20E-13"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg43_1"
                     /protein_end="354"
                     /protein_start="332"
                     /score="43.3"
                     /tool="antismash"
                     /translation="MHHIVSDGWSMGVLVKEVAALYE"
     CDS_motif       1112..1150
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_1_0004"
                     /evalue="2.30E-07"
                     /label="C4_LCL_164-176"
                     /locus_tag="ctg43_1"
                     /protein_end="383"
                     /protein_start="370"
                     /score="23.0"
                     /tool="antismash"
                     /translation="QYADFAVWQREWLK"
     CDS_motif       1403..1492
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_1_0005"
                     /evalue="5.30E-18"
                     /label="C5_LCL_267-296"
                     /locus_tag="ctg43_1"
                     /protein_end="497"
                     /protein_start="467"
                     /score="57.3"
                     /tool="antismash"
                     /translation="DILVGTPIANRSRAETKDLIGFFVNTLVLRG"
     CDS_motif       1541..1660
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_1_0006"
                     /evalue="6.60E-19"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg43_1"
                     /protein_end="553"
                     /protein_start="513"
                     /score="60.3"
                     /tool="antismash"
                     /translation="REVCLNAYTHQDAPFEKLVEEMQPERAANRTPFFQVWFALQ"
     CDS             2021..3697
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 352.5; E-value: 5.7e-107)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_2"
                     /sec_met_domain="PF04055 (E-value: 6.2e-26, bitscore: 79.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTRESLDCVVLGYNEVPFDRYERFLRNYGEDTEAYRDLKFSFVD
                     LDGQKLDYMGLLNYVHAQARAELGLSPVAREEFLSGDIPNLAAVYLTNFLRNHGCRAQY
                     INLFQHEKERLIEYLEADPLCVAITTTFYVVNLPVNEMVEFIRRHNSKVKIVVGGPLVS
                     NYARHTEGDQFKAALEDMGADIYVVEGQGEWTLWQVVECLKNGGSLGKVPNLAYLENGQ
                     LQRTRTVPENNSLDENYINWTSFPDEQLGTTIQTRTARSCAFKCSFCNYPTRAGALSLT
                     SLDVVERELNSMRELGNVQNVVFIDDTFNVPFPRFKELCRMMIKNKYDFNWFSYFRCSN
                     SDEEAIELMARSGCKGVFLGIESGSPRILTNMNKSATVEKYAKGMEWLRRYGILSFGSF
                     ITGFPGETEETVKETVEFIQQNKPDYYRSQMWYCEPGTPIQNRRAEFNIQGEGFVWNHA
                     TMDSLEAMDHIDQMFLTIKDSIWLPQWSFDFWTIPYLTGKGISRDQFRALMTQAHQLLT
                     LEIASVTEQKKHSLQQQLVRNLVQVAKEWQQPAELSLPVCV"
     CDS             3800..6850
                     /NRPS_PKS="Domain: AMP-binding (270-667). E-value:
                     2.6e-112. Score: 367.1. Matches aSDomain:
                     nrpspksdomains_ctg43_3_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (776-842). E-value: 1.3e-28. Score:
                     90.8. Matches aSDomain: nrpspksdomains_ctg43_3_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (864-1016). E-value:
                     1.6e-56. Score: 183.2. Matches aSDomain:
                     nrpspksdomains_ctg43_3_Condensation_LCL.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     342.8; E-value: 4.6e-104)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_3"
                     /sec_met_domain="Condensation (E-value: 4.3e-45, bitscore:
                     141.7, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-122, bitscore:
                     396.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.5e-20, bitscore:
                     59.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSETTFRLLSEKLETEKAYWLRKLDGALTVTGLPLDFDRAAANGK
                     RSALKFRLETDIEQRLRTICGNSELLIFVAFVTALKICLHKHTGNEDIIVGTTIHKRYA
                     EITGLNKFLALRDRVRSGMTLKQLLLEVKGTIVEAYAHQKYPFDNILRLLNFGSRDDRT
                     IFNVAIALENVNDEKYLHDLKTDVTCVLKVEQVEISGTLEYNPGLFVPATIESFGRQFQ
                     EVLRAILNTPDLQIGQLELLSFDKKQQFLSAFNRTQRDYPRDRALHQLFAEQVLRTPEA
                     IACTFEQQALTYEELNLRANQLAHYLLKRGIGPGARIGIYLEHSFETLIALLGVLKTGA
                     AYVPLDPQHPRARLALMIEDAAIRLVLTQQRLTSRLPSANATHLLCLDEQWPVIAAESI
                     TNPSVAVSSSSLAYVIYTSGSTGKPKGVAISHRALVNYIEWAKEVYLDDGPCTFALYSS
                     LAFDLTVTSIYTPLLSGNKVVVYGKEAGHFALLQIVKDQQTNVLKLTPSHLALLKDMNN
                     RGSSVRRLIVGGEALSSKLAEQIHASFGEQIEIINEYGPTEATVGCMIYRFAPERDRRA
                     YVPIGRPAANTQIYILDEALNPLAENVIGELYIAGDGLAEGYLNREDLTTEKFIPNPFT
                     PGQKMYKTGDLARRLPEGELEYVGRKDEQVKYHGHRIELREITSILNRHPDVRNSIVAV
                     RKDRNGNDVLIAYYVSRHKLDTNALRILLSEHIVEETIPNIFVHLKRIPLTVNGKVNLE
                     ALPGVEEARSRIERTYVTPMAPAEEALAEIWSNVLGVNQIGIDDNFFVLGGHSLLATQM
                     LSRVREVFQVELPLRTLFELPTIRALAKNVEVLMKGEERIVLPPLQRVGRDGPAPLSFA
                     QQRLWFLAQLEPESAFYNIPLAVRLKGELKLAALEATLSEVVRRHEVLRTTFSVREGEP
                     VQIIREAERVRLSVEDLSELSEAEREAEAGRRAAAEAQAPFDLEQGPLLRIRVLRLAAS
                     EHVVLLTMHHIVSDGWSMGVLVKEVAAL"
     CDS_motif       4202..4264
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_3_0001"
                     /evalue="3.10E-06"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg43_3"
                     /protein_end="155"
                     /protein_start="134"
                     /score="19.4"
                     /tool="antismash"
                     /translation="TIVEAYAHQKYPFDNILRLLNF"
     aSDomain        4610..5800
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_3_AMP-binding.1"
                     /evalue="2.60E-112"
                     /label="ctg43_3_AMP-binding.1"
                     /locus_tag="ctg43_3"
                     /protein_end="667"
                     /protein_start="270"
                     /score="367.1"
                     /specificity="consensus: asn"
                     /tool="antismash"
                     /translation="FAEQVLRTPEAIACTFEQQALTYEELNLRANQLAHYLLKRGIGPG
                     ARIGIYLEHSFETLIALLGVLKTGAAYVPLDPQHPRARLALMIEDAAIRLVLTQQRLTS
                     RLPSANATHLLCLDEQWPVIAAESITNPSVAVSSSSLAYVIYTSGSTGKPKGVAISHRA
                     LVNYIEWAKEVYLDDGPCTFALYSSLAFDLTVTSIYTPLLSGNKVVVYGKEAGHFALLQ
                     IVKDQQTNVLKLTPSHLALLKDMNNRGSSVRRLIVGGEALSSKLAEQIHASFGEQIEII
                     NEYGPTEATVGCMIYRFAPERDRRAYVPIGRPAANTQIYILDEALNPLAENVIGELYIA
                     GDGLAEGYLNREDLTTEKFIPNPFTPGQKMYKTGDLARRLPEGELEYVGRKDEQVKYH"
     aSModule        4610..6325
                     /complete
                     /domains="nrpspksdomains_ctg43_3_AMP-binding.1"
                     /domains="nrpspksdomains_ctg43_3_PCP.1"
                     /locus_tags="ctg43_3"
                     /monomer_pairings="asn -> asn"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4796..4837
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_3_0002"
                     /evalue="9.80E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg43_3"
                     /protein_end="346"
                     /protein_start="332"
                     /score="18.7"
                     /tool="antismash"
                     /translation="LGVLKTGAAYVPLDP"
     CDS_motif       5033..5092
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_3_0003"
                     /evalue="4.60E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg43_3"
                     /protein_end="431"
                     /protein_start="411"
                     /score="34.4"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVAISHR"
     CDS_motif       5603..5686
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_3_0004"
                     /evalue="7.70E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg43_3"
                     /protein_end="629"
                     /protein_start="601"
                     /score="43.8"
                     /tool="antismash"
                     /translation="NVIGELYIAGDGLAEGYLNREDLTTEKFI"
     CDS_motif       5768..5830
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_3_0005"
                     /evalue="3.50E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg43_3"
                     /protein_end="677"
                     /protein_start="656"
                     /score="28.9"
                     /tool="antismash"
                     /translation="YVGRKDEQVKYHGHRIELREIT"
     aSDomain        6128..6325
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_3_PCP.1"
                     /evalue="1.30E-28"
                     /label="ctg43_3_PCP.1"
                     /locus_tag="ctg43_3"
                     /protein_end="842"
                     /protein_start="776"
                     /score="90.8"
                     /tool="antismash"
                     /translation="EEALAEIWSNVLGVNQIGIDDNFFVLGGHSLLATQMLSRVREVFQ
                     VELPLRTLFELPTIRALAKNVE"
     aSDomain        6392..6847
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg43_3_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.60E-56"
                     /label="ctg43_3_Condensation_LCL.1"
                     /locus_tag="ctg43_3"
                     /protein_end="1016"
                     /protein_start="864"
                     /score="183.2"
                     /tool="antismash"
                     /translation="PAPLSFAQQRLWFLAQLEPESAFYNIPLAVRLKGELKLAALEATL
                     SEVVRRHEVLRTTFSVREGEPVQIIREAERVRLSVEDLSELSEAEREAEAGRRAAAEAQ
                     APFDLEQGPLLRIRVLRLAASEHVVLLTMHHIVSDGWSMGVLVKEVAAL"
     aSModule        6392..6847
                     /domains="nrpspksdomains_ctg43_3_Condensation_LCL.1"
                     /incomplete
                     /locus_tags="ctg43_3"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6404..6433
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_3_0006"
                     /evalue="2.70E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="ctg43_3"
                     /protein_end="878"
                     /protein_start="868"
                     /score="10.3"
                     /tool="antismash"
                     /translation="SFAQQRLWFLA"
     CDS_motif       6455..6568
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_3_0007"
                     /evalue="1.80E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg43_3"
                     /protein_end="923"
                     /protein_start="885"
                     /score="58.9"
                     /tool="antismash"
                     /translation="AFYNIPLAVRLKGELKLAALEATLSEVVRRHEVLRTTFS"
     CDS_motif       6788..6850
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg43_3_0008"
                     /evalue="5.40E-12"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg43_3"
                     /protein_end="1017"
                     /protein_start="996"
                     /score="38.1"
                     /tool="antismash"
                     /translation="MHHIVSDGWSMGVLVKEVAAL"
ORIGIN
        1 gttaggagaa gtggaagcca gcttacgcaa tcacgagtgg gtacgagaag cagtcgtggt
       61 agtgcgcgag gagaaggcgg gagacaagcg gctggtggcc tatgtggtgc tggaccagag
      121 cagcgcggca gcggcggagg cggaggagaa gtggagcagt ccactgcggc agtatctgaa
      181 ggcacgcttg cctgagtaca tgattccagc agcgtttgtg aaattggcgc agttgccgct
      241 gacggcgaac gggaaagtag atcggagagc gctaccggcc ccggcaatgg cagcagtggc
      301 agtagcggga gcggaagagc gagtgctgac gccgagcgaa gagttggtgc gtggcatctg
      361 gatggaagtg ctggggctgg ggcaggtgag tgtgaatgcc gacttcttng agttaggcgg
      421 acattcactg ttggctacgc aggttatctc gcgagtgcgg gaggtgtttg gcgtggaagt
      481 gccgttgcgc gtgctgtttg aggagccgac ggtggccgca ctggcgcaag ccgtagagca
      541 ggaacagcag gcggcgcgcg gctatcgttt agggtcgata acggcagtgg cgcgagagca
      601 ggtcttgccg ctgtcatttg cgcagcagcg gttgtggttt ctggcgcagt tggaaccgga
      661 gagtgctttc tacaacgtgc cgctagcggt gcggttaaag ggagagctga agctggcggc
      721 gctggaggcg acgttgagcg aggtggtgcg gcggcatgaa gtgctgcgaa ccacgttcag
      781 tgtgcgagag ggcgagccgg tacagatcat tcatgaggct gagcgggtgc ggctcagtgt
      841 cgaggacctc agcgagctga gcgaggcgga gcgtgaggcc gaagcgggac ggcgcgcggc
      901 ggcggaagcg caggtgacgt ttgacctgga gcaagggccg ttgctgcgga tcagagtgtt
      961 gcgtttggcg gctagcgaac atgtggtgct gttgacaatg caccacattg tgagcgatgg
     1021 ctggtcaatg ggagtgctgg tgaaagaggt ggcggcgctc tatgaagcat atgcggcggg
     1081 gcaggcgtcg ccgttggcgg agttggggat tcagtatgcg gactttgcgg tgtggcagcg
     1141 cgagtggctg aaaggagaag tactggaagc gcagttggga tactggcgcc ggcaattggc
     1201 gggagcgccg gcgctgctcg aattgccgac tgattatccg cggcagtcaa ttccgagtta
     1261 tcgcggagca ctagagccac tcagtttacc gcgtgccctc agtgatgctc tgaagagcct
     1321 aagccggcgt gaaggggtaa cgctcttcat gacgttactg gcggcgtggc aggtactatt
     1381 ggcacggtac tcgggtcaag aggacatttt agttggcaca ccgatcgcga atcgcagccg
     1441 tgccgagaca aaagatttga ttggcttctt tgtgaatact ctggtattgc gaggcaattt
     1501 gcgaggagac ccaagttttc tcgaagtgct gtggcgcacc cgagaagttt gtttgaatgc
     1561 ttacactcac caggatgctc catttgagaa gctggtcgaa gaaatgcagc ccgagcgggc
     1621 ggcgaaccgc accccgttct ttcaagtatg gtttgcgttg cagaacctgc cggtgagtaa
     1681 cgtcgaacta tctgatttga aaatgagttt gttggaagtg cccaatgcaa cgtcgaaatt
     1741 tgatttgacc ctcgctgtac aagagacagg tgacattatc gatggcgcgt tggaatacga
     1801 cacaaacttg ttcaattctg ccacgattag tcggctgctg aatcattttg aaagactact
     1861 gcggagcatt gtggcccaac ccgaggccag aataagcgag ttggaaatac tttcggaaga
     1921 tgagtacacc cccctcagtc aggtaattcc tatcgatgag ctcaaccaga gctttttctt
     1981 ctaaaccaat tcatcaaaac attaagtagg acgaacagct atgaagacta gagagagtct
     2041 ggattgtgtc gtgctcggtt ataacgaagt cccatttgat cgttacgagc gctttctcag
     2101 aaactatggc gaagatacag aggcttatcg cgatctaaag tttagcttcg ttgatttgga
     2161 tggtcagaag ctggattaca tgggcctcct gaattatgtt cacgcgcagg caagggcgga
     2221 gctgggttta agcccggtgg cacgagaaga gttcctgtca ggcgacattc ccaatctcgc
     2281 agccgtgtac ctgactaact ttctccgtaa tcacggttgc cgggcccagt acataaatct
     2341 ctttcagcat gagaaagaga ggttgattga atatctcgaa gctgatccgc tgtgcgttgc
     2401 tattacgacc acattctacg tcgtcaatct accagtcaac gaaatggtgg agttcatcag
     2461 acgtcacaac agcaaagtga agattgtagt aggtgggcca ctggtctcta actatgcacg
     2521 ccatactgaa ggggatcaat tcaaggcggc gctggaagac atgggggcgg atatttatgt
     2581 cgtcgagggc cagggagagt ggacgctctg gcaggtagtc gagtgcctga agaatggcgg
     2641 cagcttaggt aaagttccta atcttgccta tctcgagaac ggacagttgc aacgcaccag
     2701 aacggtaccc gaaaacaact cgctcgacga gaattacatc aactggactt catttccgga
     2761 tgaacagctt ggcaccacca ttcagaccag gaccgcacgc agttgcgctt tcaaatgttc
     2821 attctgcaac tacccaacgc gcgccggcgc gctgagcctg accagtctgg acgtcgtcga
     2881 gcgagagctc aattcgatgc gtgaactggg aaacgtacaa aacgtagtct tcatcgacga
     2941 caccttcaac gttccctttc ctcgttttaa agagttatgc cggatgatga tcaagaataa
     3001 gtatgacttt aattggttct catacttccg ttgcagcaat tcggacgagg aggccatcga
     3061 gttgatggcg cggagtggtt gcaagggagt ctttctcggt atcgaatcgg gctcgccaag
     3121 aattctaacg aatatgaata agtcagcgac tgtggaaaag tatgcgaaag ggatggaatg
     3181 gctgcggcgc tacggcattc tgagttttgg ctcgttcatc actgggttcc ctggagaaac
     3241 ggaggagacg gtcaaggaaa ccgttgaatt cattcagcag aataagcctg actattaccg
     3301 ttcgcaaatg tggtattgcg agcctggcac acctattcag aaccggcgag cagagttcaa
     3361 cattcagggt gaaggtttcg tctggaacca cgccacgatg gacagtctgg aagcgatgga
     3421 tcatatcgat caaatgttct tgacgatcaa ggattcgatc tggctgccgc agtggtcctt
     3481 tgacttttgg accattccct acttaaccgg caaaggcatt tcacgtgatc agtttcgcgc
     3541 gctgatgacg caggcccacc aactgctcac gctggaaatc gcttctgtga ctgaacagaa
     3601 aaagcattct ctccagcaac agttagtcag gaatctggta caggttgcaa aggagtggca
     3661 gcaacctgct gagttgagcc tgccggtctg cgtctaatcg tcaacttcaa actttattca
     3721 ccagtttcga tcgcctgtgg cccaatctga ttcccccaca gcttgataat gcttcgccat
     3781 cattccatag agttcagata tgagtgagac aaccttcaga ttactcagcg aaaagcttga
     3841 gaccgagaaa gcatactggt tacgtaagct ggatggtgcg ttaactgtta ctgggctgcc
     3901 gctcgatttt gacagggccg ccgctaacgg aaaaagaagc gcgctcaagt tcaggctcga
     3961 aacagatatc gagcaacggt tgcgtacgat ctgcggcaac agcgaactgc tgattttcgt
     4021 cgcattcgtg acggccctta agatctgttt acataagcat acgggcaacg aagatattat
     4081 cgtcggaacc accatccaca agcgttatgc tgagatcacc gggctcaata agttcctcgc
     4141 cttgcgcgat cgagtgcgct ctggcatgac cctcaagcaa ttgctgctcg aagttaaggg
     4201 cactattgtc gaggcctacg cccaccagaa atatcccttc gataacattt tgcgcctgct
     4261 gaactttgga tcacgcgatg acaggaccat ctttaatgtg gccatagctt tggagaacgt
     4321 gaacgacgaa aaatatctcc acgacttgaa aactgatgtg acctgcgttc ttaaggtcga
     4381 gcaggtagag ataagcggca cacttgaata caatccgggc ttgtttgtgc cggcgaccat
     4441 tgaatcgttt ggcaggcaat ttcaagaagt cctcagagct attctgaata cgcccgatct
     4501 tcagatagga cagcttgaac ttctctcttt tgacaagaaa cagcaatttc tctcggcgtt
     4561 caatcgcaca caacgcgact acccacggga ccgggctctt caccagctct ttgcggagca
     4621 ggttttgcgc acacctgaag cgatcgcctg cacctttgaa cagcaagcgc tgacttacga
     4681 ggaactgaat ctacgagcaa atcagttggc ccactacctg ctcaaacggg gcattgggcc
     4741 gggcgcacga atcgggattt acctggaaca ttcgtttgag acgctgatcg ctttgctcgg
     4801 cgtgctcaag acgggtgccg cttatgtacc actcgatccg cagcacccgc gcgcccgtct
     4861 tgctctaatg attgaagatg cggccattcg tctcgtcctg acgcaacaga ggctaacttc
     4921 tcgcctgcca tctgcgaatg cgacccacct gctatgcctg gacgagcaat ggccggtgat
     4981 tgcggcagaa agtattacca atccgtctgt agcggtctcc tcaagcagtc tggcttacgt
     5041 aatctacacc tccggctcga ccggcaagcc caagggggta gccatctcgc atcgcgcgtt
     5101 ggttaactac atcgagtggg ccaaagaagt ttatctggat gatggtccat gcaccttcgc
     5161 tttatattca tcgttggcct tcgacctgac cgtcacttca atctacaccc cgttgttgag
     5221 tggtaataag gtcgtcgttt acggtaaaga ggccggccat ttcgcgctcc tgcaaatcgt
     5281 caaggaccag caaacaaatg tgctgaaact aacgccgagt catcttgcgc tcctcaaaga
     5341 tatgaacaat cgcggcagta gcgtcagacg tctcattgtc ggcggcgagg cgttgtcgtc
     5401 gaagctggct gaacagatcc acgccagttt tggcgagcag attgagatta tcaatgaata
     5461 tggaccgacg gaggcgaccg tcggttgcat gatttatcgt ttcgcgccgg agcgagatag
     5521 gcgtgcctac gtgcctatag gccgcccggc tgctaatact caaatatata ttttggacga
     5581 agctttgaac ccgctcgcgg aaaatgtaat cggtgagttg tatattgccg gtgatggatt
     5641 agccgaaggt tatttaaatc gagaagatct cacgaccgaa aaattcattc ccaatccgtt
     5701 cactcctgga caaaagatgt ataagaccgg cgaccttgcg cgcagactgc cggaaggcga
     5761 gctggaatat gtcgggcgca aagacgaaca ggtgaaatat cacggacacc ggattgaact
     5821 ccgtgagatt acaagtatct tgaacaggca ccccgacgta cgcaacagca tcgtggcggt
     5881 gcgcaaagat cgcaatggca acgacgtgtt aattgcctat tacgtttcgc gtcataagct
     5941 ggatactaac gccctgcgca tactgctctc agagcatatc gttgaagaga ccatcccaaa
     6001 tattttcgtg caccttaagc ggattccgtt gacagtgaac gggaaagtca acctggaagc
     6061 tttgccaggt gtagaagagg cacgcagcag gattgagcgc acgtatgtga ctcccatggc
     6121 gcccgccgaa gaagcgctgg ctgaaatctg gtccaacgtg ctcggcgtca atcagatcgg
     6181 cattgacgat aactttttcg tcctgggtgg ccattccttg ctagccacac agatgctttc
     6241 tcgggtacgt gaagtctttc aagtcgaact acctctccgt actttatttg agctacctac
     6301 gattagagca ctcgcaaaaa atgtggaagt attgatgaaa ggagaggagc gcatcgtgct
     6361 gccgccgctg cagagggttg ggcgagatgg tccagctccg ctgtcgtttg cgcagcagcg
     6421 cctatggttt ctggcgcagt tggaaccgga gagtgctttc tacaacattc ctttggccgt
     6481 gcggttaaaa ggagagctga agctggcggc actggaggcg acgttgagcg aagtggtgcg
     6541 gcggcatgaa gtgctgcgga ccacgttcag tgtgcgagag ggcgagccgg tacagatcat
     6601 tcgtgaggcg gagcgggtgc ggctcagtgt agaagacctc agcgagctga gcgaggcgga
     6661 gcgtgaggcc gaagcgggac ggcgcgcggc ggcggaagca caggcgccgt ttgacctgga
     6721 gcaagggccg ttgctgcgga tcagagtgtt gcgtttggcg gccagcgaac atgtggtgct
     6781 gctgacgatg caccacattg tgagcgatgg ctggtcgatg ggagtgctgg tgaaggaggt
     6841 ggcggcgctc ta
//
