LOCUS       c00169_3300006..        8737 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300006056.a:Ga0075163_10019255.
ACCESSION   c00169_3300006..
VERSION     c00169_3300006..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 18:59:07
            Original ID  :: 3300006056.a:Ga0075163_10019255
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8737
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..807
                     /NRPS_PKS="Domain: ECH (1-241). E-value: 7e-50. Score:
                     161.3. Matches aSDomain: nrpspksdomains_ctg169_1_ECH.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 226.4; E-value:
                     5.1e-69)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg169_1"
                     /transl_table=11
                     /translation="GDIRCITLDRPERRNAFDSRMISELTQAFDESAQEPSLRGVLLSS
                     AGPVFCAGADLQWMQSTSPISEAQAQDDAHRLTRMFRAIDECPCPVIARVQGPAFGGGL
                     GLMAVCDIVVAAEDAMFSLSEARLGLIPAVIAPFLLRKAGESFLRRYALTGETFTTSVA
                     HRFGLVHDVVSQHDLDDRITEVIDAIRQLAPRATRATKGLILRIRPLPDQERGVTCAEA
                     NANARAASEAIEGLRAFTEKRPPQWAKEQQPAREIAKEHHVASRPT"
     protocluster    1..8737
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[784:7690]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      785..7690
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..8737
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8737
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     aSDomain        4..723
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg169_1_ECH.1"
                     /evalue="7.00E-50"
                     /label="ctg169_1_ECH.1"
                     /locus_tag="ctg169_1"
                     /protein_end="241"
                     /protein_start="1"
                     /score="161.3"
                     /tool="antismash"
                     /translation="DIRCITLDRPERRNAFDSRMISELTQAFDESAQEPSLRGVLLSSA
                     GPVFCAGADLQWMQSTSPISEAQAQDDAHRLTRMFRAIDECPCPVIARVQGPAFGGGLG
                     LMAVCDIVVAAEDAMFSLSEARLGLIPAVIAPFLLRKAGESFLRRYALTGETFTTSVAH
                     RFGLVHDVVSQHDLDDRITEVIDAIRQLAPRATRATKGLILRIRPLPDQERGVTCAEAN
                     ANARAASEAIEGLRAFTEK"
     CDS             785..1732
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 195.4;
                     E-value: 2.9e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg169_2"
                     /sec_met_domain="HMGL-like (E-value: 1.8e-47, bitscore:
                     151.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLQAGLHNLRQASVRITEVSPRDGLQHESEFVPTLRKISLINALS
                     RTGVAEIEASSFVSPAAIPQLADSDEVLRAIDRIPGVTYSALVPNERGLERARAAGVDK
                     IAVFTAASNSFTRHNIKATVQESLVRFRPIVAAAKRDGLAVRAYLSTVVFCPYEGRIAP
                     AQVRDVMERLLDLAVDDISLGETIGKASPTDIRRLLDTVLPHVEPARLSLHFHDTYGMA
                     VANALTAWWDYGITAFDASAGGLGGCPYAPGASGNVATEDLVFALKASGANVPVDELLV
                     AACAQQLGDAVRHPLNSRLSQLHHREKPQPAWRE"
     CDS             1734..2507
                     /locus_tag="ctg169_3"
                     /transl_table=11
                     /translation="MNHACVGRLSKREDVETMARQVLAGGVRAVARVITWIENQEPVGA
                     VVLKRLTPPEKRAMVIGITGYPGTGKSTLIDQLIAAYRRLGKTVGVLAVDISSPLTGGA
                     VLGDRIRMQRHADDAGVYIRSMATRGQSGGLARATRDALQVLEAAAYDVILIETVGVGQ
                     SDIEVVSVAGTVIALVAPGLGDDVQAMKAGLLEVADIVVVNKGDREGADTAVRDLREWC
                     PHVLRTVAVKGEGIPELIAMIAEQQRLQDLAHTPG"
     CDS             2537..3940
                     /locus_tag="ctg169_4"
                     /transl_table=11
                     /translation="MLADRLASYTQALCYDDLPGDVVHEVKRRILDSAACAFGAWKATP
                     CRIARHVAQSAKVPGGATIWGTSHKTLPDLAAFANGALVRYLDFNDTYLSKEPAHPSDN
                     LAAILAAGEIAHASGKRVIQAIALAYEIQCRLCDAAALRSRGWDHVTYGSISSALGAAK
                     TLKLTEAQTTQAINLAAVANVALRQTRVGEMSMWKACAFSNAARNGLFAAILAQRGMTG
                     PAPIFEGEKGFMKLVSGPFELSRLGGERAPDDTLASFKILDSYIKHFPVEYHAQTAVEA
                     ALALRAEVIKAEGADAIQRLSEIEIGSYDVAIEIIGRDPEKWHPTTRETADHSFPYCVA
                     VALLDGRVTLHSFDPHRLRDAALHELMKKVRVVPQPEFAGRYPGAMPTRLTLRTTTGTV
                     YMRHVDVPLGHPGNPMSDQDVEDKLRRLASRRIGLAQVEKLIGFVWTLEREKDIATLMP
                     LLRVPHRDA"
     CDS             3930..4874
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 256.4;
                     E-value: 5.5e-78)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg169_5"
                     /transl_table=11
                     /translation="VMRNHSTPSKAQRLRELLAGRTVAIPGACNALTAMQIERAGFEIV
                     YVSGAAISAAHGMPDIGLISLTDMTREASAIARSVALPTIVDADTGYGPPSVVREAVQE
                     FERAGLAGMQIEDQEEAKKCGHLSGKRLIPTADMVAKITAAVEAKCDRDFVLVARTDAR
                     TVDGLQAAIQRGVAYANAGADALFPEALLSADEFHTFALEMNRAGVHLPLIANMTEFGK
                     TPYLSVDEFETLGYRGVLFPVSTLRVAALAVEKLLRELRFFGSQRAWLDHMMTRQELYS
                     LLRYEHGQNQTGRPYEPGDTRTARNENHGAPPL"
     CDS             4816..5994
                     /locus_tag="ctg169_6"
                     /transl_table=11
                     /translation="MNQAIQEQPGTKTTERPLYSPGLEGVIAGESALCQVDEGEAGLRY
                     RGYAIGDLAKWSRFEEVAYLLLIGHLPTRSELDSFSTLLRGHRVLPDPVQRFIDSLQPG
                     LHPMDVLRTGISLLGLSDPDAQDGSHEANLRKSMRLLSQIPLLIAHSYRVMSGILPPRQ
                     DESRDFAQHLLHLVAGHKDGESGAAMAQALNVSLILYAEHEFNASTFAARVTASTLTDL
                     HGAVTAAVATLKGPLHGGANEAVASMLMEIGSPERAETWAREALAQKRRVMGFGHRVLR
                     QGDARSTIIQRHAERLSHLCGDHSWYDIASTLHRIMREEKGLHPNLDFYTAVAYLLMGI
                     PRELSTPLFVCSRITGWCAHVMEQQEHNRLIRPRALYTGPAPRTYEPLDRRP"
     CDS             5969..7690
                     /NRPS_PKS="Domain: AMP-binding (57-462). E-value: 6.2e-83.
                     Score: 270.3. Matches aSDomain:
                     nrpspksdomains_ctg169_7_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     324.1; E-value: 2.1e-98)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg169_7"
                     /sec_met_domain="AMP-binding (E-value: 6.8e-89, bitscore:
                     287.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLTDVHDRIEQAREAPGCSSELHWTSFAEFFRSRLYDPRLVTR
                     NFLTYCDDDRNLRRTYSYAEFGTIVERMAEMFHTKFGLTRGDRIATVLFNHDLTALIYF
                     AAWTLGVAVVPINVEETPEKKRYILEHSEASVALCWQDVYEELKALQSMLPALREVVAL
                     GDGGILDGKETRGKSRKNSHAVGARFAPGTSRLDDPALIIYTSGTTGPPKGVILTVANL
                     LIDADAIADRHGFGLTDRLMCVLPVHHVNGIVVTLMTPFYCKGSVVLNRKFKTGSFWRR
                     LHEEQVTSVSVVPTLLEFLLDADEDLAAYRLDRFGGVICGAGPLLKDTALRFEERFGFP
                     IRHGYGLSETTCYSCFLPNDLTGEEHRHWLTDFDFPSIGTALRHNEMAILDESGKAVAE
                     QARGEICIRGRTVCAGYFKRDDANEVAFQWGWFRSGDEGFYIADDRGRPFFFISGRLKE
                     LIVRGGVNISPLEIDDVLKGHPAVQFAMALPFENRYYGEEIAAYIVPKDPESPPTEADI
                     LSHCRGRLPFAKQPKVLMMGTEVPYTSTGKPKRLELKSRLAGTLAQYRDRQFKDPG"
     aSDomain        6140..7354
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg169_7_AMP-binding.1"
                     /evalue="6.20E-83"
                     /label="ctg169_7_AMP-binding.1"
                     /locus_tag="ctg169_7"
                     /protein_end="462"
                     /protein_start="57"
                     /score="270.3"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="RRTYSYAEFGTIVERMAEMFHTKFGLTRGDRIATVLFNHDLTALI
                     YFAAWTLGVAVVPINVEETPEKKRYILEHSEASVALCWQDVYEELKALQSMLPALREVV
                     ALGDGGILDGKETRGKSRKNSHAVGARFAPGTSRLDDPALIIYTSGTTGPPKGVILTVA
                     NLLIDADAIADRHGFGLTDRLMCVLPVHHVNGIVVTLMTPFYCKGSVVLNRKFKTGSFW
                     RRLHEEQVTSVSVVPTLLEFLLDADEDLAAYRLDRFGGVICGAGPLLKDTALRFEERFG
                     FPIRHGYGLSETTCYSCFLPNDLTGEEHRHWLTDFDFPSIGTALRHNEMAILDESGKAV
                     AEQARGEICIRGRTVCAGYFKRDDANEVAFQWGWFRSGDEGFYIADDRGRPFFFISGRL
                     KELIVRG"
     aSModule        6140..7354
                     /domains="nrpspksdomains_ctg169_7_AMP-binding.1"
                     /incomplete
                     /locus_tags="ctg169_7"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6566..6622
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg169_7_0001"
                     /evalue="2.70E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg169_7"
                     /protein_end="218"
                     /protein_start="199"
                     /score="23.0"
                     /tool="antismash"
                     /translation="ALIIYTSGTTGPPKGVILTV"
     CDS_motif       7172..7249
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg169_7_0002"
                     /evalue="3.50E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg169_7"
                     /protein_end="427"
                     /protein_start="401"
                     /score="16.2"
                     /tool="antismash"
                     /translation="RGEICIRGRTVCAGYFKRDDANEVAFQ"
     CDS             7712..8737
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 222.9; E-value:
                     1.2e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg169_8"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.3e-24, bitscore:
                     74.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.2e-19, bitscore:
                     59.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.8e-08, bitscore:
                     23.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLFTGFERIEEARERFTGKSFLAGLYDGRPDFDLLLTPPEPPE
                     EKAAGEAFCKQVEHFLIHEVDPQEIEREAKIPERVIQGLFKLGAFGMKIPKEYGGLGLS
                     YTNYARVLTLIAGWSNILALTVAVPQSIGIAMPILLFGNADQKRKYLPLVAKEAISAFA
                     LTEPMTGSDAANVRTEAVLDSSGTHFLVNGEKLWCTNGPIARYLTLVARVPALRVECEG
                     KVEWIPAPQGQRADDHVHTAFILDMATPGVLVRQRCQFEGCRGIENAHIALKNVQVPIE
                     QVIGDIGKGLKYALTILNVGRGISIPAICLGMAKQAWQPTLDRANSRVTFQKPLAERQT
                     QQ"
ORIGIN
        1 ggcgacatcc gctgcatcac gctcgatagg cctgaacggc gcaacgcctt cgacagccgg
       61 atgataagtg aactgactca ggcattcgac gaatcggctc aggagccgtc cctgagagga
      121 gtgttgctat ccagcgccgg accggtcttt tgcgccgggg ccgatctcca gtggatgcaa
      181 tccacgtcac cgatctcgga agcccaggca caggatgacg cccatcgtct tacccgcatg
      241 tttcgcgcga tcgacgaatg cccttgcccg gtcatcgcca gggtacaggg acctgccttc
      301 ggcggcgggc tcggattaat ggcggtctgc gatatcgtcg tcgcggcgga agatgcgatg
      361 ttttcgctca gcgaggccag gctcggtttg attccggcgg tcatcgcacc ctttctcctg
      421 cgcaaggcag gcgaatcgtt tcttcgacgg tatgcgctga ccggcgaaac attcaccaca
      481 tcggtggctc atcgattcgg cctcgtgcat gacgtcgtat ctcaacacga tctagacgat
      541 cgcatcacgg aagtcattga cgccatcagg cagctggctc cccgcgcaac cagggcaaca
      601 aaagggttga tcctgaggat acgcccgttg cccgatcaag agcgcggggt gacctgcgca
      661 gaggccaacg caaacgctcg tgctgcttcc gaagcgattg aagggctccg cgcctttacg
      721 gagaagcggc caccacagtg ggccaaggaa cagcagccag cacgggagat agcgaaggaa
      781 caccatgttg caagccggcc tacataactt gcggcaagcc tccgtccgga ttaccgaggt
      841 gtctccgcgc gacggtctgc aacacgaatc ggaattcgtg ccgaccctgc gcaaaatctc
      901 gttgatcaat gccctgtcac gaaccggcgt ggctgagatt gaagcgagct ccttcgtgtc
      961 acccgcggcc atcccgcagc ttgcggattc cgatgaggtc ctccgcgcca tcgaccgcat
     1021 cccgggtgtc acctattcgg ccctcgttcc gaacgaacgc ggcctcgaac gggcgcgggc
     1081 ggcaggcgtc gacaagatcg ccgtcttcac ggctgcctcg aacagcttta cccgccataa
     1141 catcaaagcg accgtgcagg agtcactcgt gcgcttcaga ccgattgtgg cggcagcgaa
     1201 acgagacggc ttggcggtga gagcctacct gtccacggtc gtgttctgtc cctatgaagg
     1261 ccgtattgca cccgcgcagg tgcgggacgt gatggaacgg ctgctcgacc tcgcggtcga
     1321 cgacatctcg ttgggcgaaa cgatcggcaa ggcttcgccc acggacatac ggagattgct
     1381 cgatacggtg ctgccgcatg tcgagccggc tcgcctctcg cttcatttcc atgacaccta
     1441 tggcatggcc gtcgccaacg ctctcacggc ctggtgggat tatggaatca cggcgttcga
     1501 tgcttcggcc ggaggcctcg gcggctgtcc ctacgcccca ggcgcatccg gaaatgtcgc
     1561 gacggaagat ctggtcttcg cgctgaaggc ctccggcgcc aacgtgccgg tggatgaact
     1621 gctggttgcc gcctgtgcgc aacaactcgg tgacgccgtg cggcatccgc tgaactcacg
     1681 gctttcgcaa ctccatcatc gtgaaaagcc acagcctgcg tggcgggaat gacatgaatc
     1741 acgcgtgcgt cggtcgatta tcgaaacggg aggatgtcga gaccatggcc aggcaagtgc
     1801 tggccggtgg ggtccgggct gtggcacgcg tgatcacctg gattgagaac caggagccgg
     1861 ttggagccgt cgtgttgaaa cgcctgacgc caccggagaa gcgcgccatg gtaatcggca
     1921 tcacgggtta tcccggcacg gggaagagca cgttgatcga tcaactcatc gccgcctacc
     1981 gccgcctcgg caaaacggtc ggcgtcctgg ccgtggatat cagcagccct cttaccggcg
     2041 gggcggtgct gggtgaccgg atcaggatgc agcggcacgc ggacgatgcg ggggtctaca
     2101 tacgcagcat ggcaacccgc ggtcagtccg gtgggctcgc gcgggcgact cgcgatgcgc
     2161 tgcaagtcct ggaagcggcc gcgtatgacg tgatcctgat cgaaacggtc ggcgtcggcc
     2221 agagcgacat cgaggtcgtc tctgtggcgg gaaccgtcat tgccctggtc gcgccgggat
     2281 tgggcgacga cgtgcaagcc atgaaggcag ggttactgga ggtcgcggat atcgtggtcg
     2341 tcaacaaagg ggatcgtgaa ggcgccgata ctgcagtacg cgatctacgc gagtggtgtc
     2401 cgcacgtgct gcgcaccgtg gccgtcaagg gggagggcat tccggagctg atcgccatga
     2461 tcgccgaaca gcaacggctc caggatctcg cacacacacc gggctgacag aacggcttgt
     2521 tgtcgagagg atcatcatgc tggcggatcg tcttgcgagt tatacccagg ccctttgtta
     2581 cgacgacctg cccggcgacg tggtccatga ggtcaagcga cggattctcg acagcgccgc
     2641 ctgtgccttc ggcgcctgga aggcaacccc ctgccggatc gcgcgtcacg tggcacaatc
     2701 cgccaaagtt cccggtggtg cgacaatctg ggggacgtcc cacaagaccc tgccggacct
     2761 ggccgccttc gccaacggcg cgttggttcg ctacctcgac ttcaacgata cctatctctc
     2821 aaaagagccg gcccatcctt cggacaacct tgccgcaatc ctcgccgccg gcgaaatagc
     2881 ccatgcttcg ggcaagcggg tcatccaggc catcgccttg gcctatgaaa tccaatgccg
     2941 tctctgcgac gccgccgcgt tacgctcccg tggatgggac catgtgacct atggatcgat
     3001 ctcctccgcg ctcggcgccg ccaaaacgct gaaactcacg gaggcgcaga ccacgcaggc
     3061 catcaacctg gccgccgtgg cgaacgtggc actccggcaa accagagtcg gtgaaatgtc
     3121 catgtggaaa gcctgtgcgt tctcgaatgc cgcacgcaac ggcctattcg cggccatcct
     3181 ggcccaacga ggcatgacag gccccgcccc catctttgaa ggcgaaaagg gcttcatgaa
     3241 gctggtgtcc ggaccattcg agctgtcgag actgggtgga gagcgggctc ccgacgacac
     3301 cctggcttcg ttcaagattc tcgattccta catcaaacat ttcccggtgg aataccatgc
     3361 ccagactgcg gtcgaagcgg cgctggccct gcgagcggag gtgatcaagg cggagggggc
     3421 cgatgcaatc cagcgtctga gcgagattga aatcggcagt tacgatgtcg cgatcgaaat
     3481 tatcgggcgc gatccggaga agtggcaccc gacgacgcgc gaaacggccg atcacagctt
     3541 cccctattgt gtcgcggtgg cgttgctgga tggtcgcgtc acgttgcatt cattcgaccc
     3601 tcaccggcta cgagatgctg cgctgcacga gctcatgaag aaggtgcgtg tcgtcccgca
     3661 gccggaattc gcgggccgtt acccgggagc gatgccgacc cgcctcacgc tgaggacgac
     3721 gacgggaacg gtgtacatga ggcatgtgga cgtccccctg ggccatcccg gcaatcccat
     3781 gtcggaccag gatgtggagg acaaactgcg ccggctcgca tcgagacgaa tcggtctcgc
     3841 gcaggtcgag aagctcatcg gtttcgtgtg gacattggaa cgagaaaaag acatcgccac
     3901 actgatgcct ctgttgaggg tgccccatcg tgatgcgtaa ccactccacg ccgtcaaaag
     3961 cacaacgcct gcgtgagctg ctggccggca ggacagtggc catccccggc gcctgtaatg
     4021 ccctgacggc catgcagatc gagcgcgccg gattcgagat cgtgtatgtg tcgggagccg
     4081 ccatctcggc ggcccatggc atgcccgata tcggattgat cagcttgacg gacatgacga
     4141 gggaagcgtc ggccattgcc cggtcggtgg cgcttcccac catcgtcgat gcggacaccg
     4201 gctatgggcc gccttcggtt gtgcgggagg ccgttcagga atttgagcgg gccggattgg
     4261 caggcatgca gatcgaagat caggaagagg cgaaaaaatg cggccatctg tcagggaagc
     4321 gactgattcc aacggctgac atggttgcca aaatcaccgc agccgtggag gcgaaatgcg
     4381 atcgggattt cgtccttgtg gcgcgcacgg acgcacggac ggtcgatggg ctgcaggctg
     4441 ccattcagcg aggcgttgcc tatgccaacg caggcgccga cgcgctcttc cccgaggccc
     4501 tgctctccgc ggacgaattc cacacctttg cgttggaaat gaaccgggca ggcgtccacc
     4561 tgcccttgat cgccaacatg acggagttcg gcaagacacc ttacttgagc gtggacgaat
     4621 tcgagacgtt gggatatcgc ggcgtgttat ttcccgtcag cacgctccgg gtcgcagctc
     4681 ttgctgttga gaagctgctg cgagaactca gattcttcgg ctctcaacgg gcttggctcg
     4741 atcacatgat gacgcgacag gagctctata gtctgcttcg atacgagcat gggcagaacc
     4801 agacagggag gccctatgaa ccaggcgata caagaacagc ccggaacgaa aaccacggag
     4861 cgccccctct atagccccgg acttgaaggg gtgatcgcgg gagaatcggc cctctgtcag
     4921 gtggatgaag gagaggcagg acttcgttat cgggggtatg ccatcggcga tctagcaaaa
     4981 tggagccgct ttgaggaagt cgcctatttg ctgctgatcg gtcatctccc cacccggagc
     5041 gaactggata gtttttccac actgctgaga ggccatcgag tcctccctga cccggtgcaa
     5101 cgttttatag acagcctgca gccgggcctg cacccgatgg acgtgttacg aaccggcatt
     5161 tccctgctgg ggctcagcga tcccgacgcg caggatggat cgcatgaggc caatctccgc
     5221 aaatccatgc gactgctgag ccagatcccg ctgctgatcg cgcatagtta tcgagtcatg
     5281 tccggaatac tcccgccgag acaggacgag agtcgagatt ttgcgcagca cctgctgcac
     5341 ctggtggcag gccacaagga cggtgaaagc ggcgcggcca tggcccaggc gctgaacgtg
     5401 tcgctcatcc tgtacgcgga gcatgagttt aatgcctcca cgtttgccgc tcgcgtcacc
     5461 gcctcaaccc tcaccgatct gcatggcgcg gtcacggcgg ccgttgcgac gttgaaagga
     5521 cccctccatg gaggcgccaa cgaagcggta gcgtcgatgc tcatggaaat cggcagcccg
     5581 gagcgagccg agacctgggc gcgagaggcg ctcgcgcaga aacggcgagt gatgggattc
     5641 gggcatcgcg tgcttcggca aggcgacgca cgatcgacta tcatccagcg ccacgccgaa
     5701 cggctcagcc acctctgcgg cgaccacagc tggtacgaca tcgcctccac cctccaccgc
     5761 atcatgcggg aggaaaaagg actccacccc aatctcgact tttatacggc cgtggcctac
     5821 ctgttgatgg gcatcccgcg tgaactgtcc acaccgttgt tcgtctgttc ccgcatcacc
     5881 ggctggtgcg cacatgtgat ggagcagcag gagcataacc ggctgatcag accacgagcc
     5941 ctctacacag ggcccgcacc gaggacctat gagcctcttg accgacgtcc atgaccggat
     6001 cgaacaggcc cgcgaggcgc cgggatgttc ctcggaactc cactggacct cgttcgccga
     6061 gttcttccga tcgcgcctgt acgacccgcg actcgtcacc aggaatttcc tgacctattg
     6121 cgacgacgac cggaacctgc gccgaaccta cagctatgcg gaattcggca cgatcgtcga
     6181 acggatggcg gagatgtttc atacgaagtt cggcctgacc cgcggcgacc ggatcgccac
     6241 cgtgctgttc aaccatgatc tgacggcgct gatctacttc gcagcctgga ccttgggagt
     6301 cgccgtcgtg ccgatcaatg tcgaagaaac acccgagaag aagcggtata tcctcgaaca
     6361 ttcggaggcc tcggtcgccc tctgctggca ggatgtctac gaggaactca aagctcttca
     6421 gtccatgctg ccggccttgc gcgaagtggt cgccctgggg gacggtggca tccttgacgg
     6481 gaaggagacc aggggaaaga gccgaaaaaa cagccacgcc gttggagccc gctttgcccc
     6541 gggcacctcc cgactcgacg atcctgcctt gatcatttac acatccggga caaccgggcc
     6601 gccgaaaggc gtcatcttga cggtggccaa tcttctgatc gatgcggatg ccatcgccga
     6661 ccggcatgga ttcggtctca ccgatcgttt gatgtgcgtc ctgcccgtcc accatgtcaa
     6721 cggcatcgtc gtcactctga tgactccgtt ttattgtaag ggaagcgtcg tcttgaaccg
     6781 gaagttcaag accggcagct tctggcgacg actccacgaa gagcaggtga ccagtgtcag
     6841 cgtggtcccc acattgcttg agtttcttct ggatgccgac gaagacctcg ccgcctatcg
     6901 cctggatcgc ttcggcggcg tgatctgcgg cgccggaccg ttgctgaagg acacggcctt
     6961 gcgcttcgaa gagcgttttg gattccccat ccgccatgga tacggtctgt ctgaaacgac
     7021 ctgctattcc tgtttcctcc cgaacgacct cacaggggaa gaacatcgtc actggctcac
     7081 agattttgat ttcccctcga tcggaacggc cctgcgtcac aacgagatgg ccattctcga
     7141 cgagtccggg aaggcggttg ctgagcaggc acgcggggag atctgcatcc gcgggcgcac
     7201 agtctgcgcc ggctatttca aacgggacga cgccaacgaa gtcgccttcc aatggggttg
     7261 gttccgttca ggcgacgaag gcttttacat cgccgacgac cggggacgtc cgttcttttt
     7321 catttcaggc cggttgaaag aactcatcgt ccgcggcggc gtcaatattt ccccgttgga
     7381 aatcgacgac gtgttgaagg gacacccggc cgtgcagttc gccatggccc tcccctttga
     7441 aaatcgctac tacggcgaag agatcgccgc ctatatcgtg ccgaaagacc cggagtcacc
     7501 gccgacggag gccgacatcc tctcccattg ccgcggacgg ttgccgtttg ccaaacagcc
     7561 gaaagtgctg atgatgggta cggaggtgcc ttacacctcc accgggaaac ccaagcgctt
     7621 ggaattgaaa tcccggttgg cgggcaccct ggcccaatat cgtgacagac aattcaaaga
     7681 tcccggttga ccggatcggg tgaggtacca gatgagcacc ctctttacag gtttcgaacg
     7741 gattgaagaa gcccgcgagc gcttcaccgg aaagagtttc ctggccggtc tctatgacgg
     7801 ccggccggac ttcgacctct tactgacacc tcccgaaccg ccggaagaga aagccgccgg
     7861 cgaggccttc tgcaaacagg tcgaacactt tttgatccac gaggtggacc cgcaagaaat
     7921 cgaacgcgaa gcaaaaattc ccgaacgcgt catccagggg ctgttcaagc tcggggcctt
     7981 cggcatgaag attcccaaag aatatggcgg actcggcttg tcctatacga actacgcgcg
     8041 ggtcctgacc ctgatcgccg ggtggagtaa cattctggct ctgacggtgg cagtgccgca
     8101 gtccatcggt atcgccatgc cgatcctcct cttcgggaac gcggaccaaa agagaaaata
     8161 tctcccgctc gtcgcgaagg aggccatttc agcctttgcc ctcaccgaac cgatgaccgg
     8221 ctcggatgcg gccaatgtgc gaaccgaggc ggtgctggat tcctccggca cccatttcct
     8281 ggtcaacggc gaaaaactct ggtgtacgaa tgggccgatt gcccggtacc tcacgctcgt
     8341 cgctcgcgtg ccggctcttc gggtggagtg cgagggaaag gtcgaatgga ttccggcacc
     8401 gcaggggcag cgggcggacg atcacgttca cacggccttt attttggaca tggcgacacc
     8461 aggtgtgctg gtgcgccaac gctgtcagtt tgaaggctgt cgcgggattg agaacgccca
     8521 tatcgccttg aagaatgtgc aggtaccgat cgaacaggtg atcggcgaca tcggcaaggg
     8581 attgaagtat gccctgacga ttctgaacgt ggggcggggc atcagcattc ccgccatctg
     8641 cctgggcatg gccaaacagg cctggcaacc gaccttggat cgagccaata gcagggtcac
     8701 gtttcagaag ccgttggcag agcggcagac gcagcag
//
