LOCUS       c00001_3300006..       11370 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300006322.a:Ga0099623_1001749.
ACCESSION   c00001_3300006..
VERSION     c00001_3300006..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 07:00:44
            Original ID  :: 3300006322.a:Ga0099623_1001749
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11370
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11370
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2555:3677](+)"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2556..3677
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     protocluster    1..11370
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1320:2550](+)"
                     /cutoff="20000"
                     /detection_rule="ladderane"
                     /neighbourhood="20000"
                     /product="ladderane"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1321..2550
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ladderane"
                     /neighbourhood="20000"
                     /product="ladderane"
                     /protocluster_number="2"
     cand_cluster    1..11370
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="ladderane"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="neighbouring"
                     /product="ladderane"
                     /product="arylpolyene"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11370
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ladderane"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="ladderane"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             1321..2550
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (84-404). E-value:
                     3.5e-48. Score: 156.2. Matches aSDomain:
                     nrpspksdomains_ctg1_1_PKS_KS.1"
                     /NRPS_PKS="type: PKS/NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ladderane: ladderane"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 321.9; E-value:
                     1.1e-97)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_1"
                     /sec_met_domain="ladderane (E-value: 3.1e-104, bitscore:
                     338.9, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTMSSDSERVVITGLGVISSIGTGTEAFARALRAGASGDRAISM
                     FDTTGYDYANGCEVVDFAPKEHLSAPELDTLGRATQFSVAAAVMAIKDSGFPIDQLRSR
                     RGVISIGTTDGESQDLDRLAETWEVAGPSQMNPTAAKRVPAGRLSIAIAEHLGLDDVEA
                     VTLPTACAAGNYAIGYGLDAIRTGEAEYALCGGADAMCRKTFTGFYRLGTIAPEKCQPF
                     DVNRKGILTGEGAGVLLIESLKSARSRGARIHAEVLGYGLTCDAYHQVAPKASSVSHCI
                     ELALEDASIRPSEVDLISAHGTGTRANDVTECAAIRDIFGSEPPRVVSVKSMIGHTMGA
                     ASALGAIACSLAIEGGFIPPTINHVSTDPDCDVDCVPNQAITADLQIVQNNGLAFGGNN
                     AVVMLGKCAR"
     aSDomain        1573..2532
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_1_PKS_KS.1"
                     /evalue="3.50E-48"
                     /label="ctg1_1_PKS_KS.1"
                     /locus_tag="ctg1_1"
                     /protein_end="404"
                     /protein_start="84"
                     /score="156.2"
                     /tool="antismash"
                     /translation="AAAVMAIKDSGFPIDQLRSRRGVISIGTTDGESQDLDRLAETWEV
                     AGPSQMNPTAAKRVPAGRLSIAIAEHLGLDDVEAVTLPTACAAGNYAIGYGLDAIRTGE
                     AEYALCGGADAMCRKTFTGFYRLGTIAPEKCQPFDVNRKGILTGEGAGVLLIESLKSAR
                     SRGARIHAEVLGYGLTCDAYHQVAPKASSVSHCIELALEDASIRPSEVDLISAHGTGTR
                     ANDVTECAAIRDIFGSEPPRVVSVKSMIGHTMGAASALGAIACSLAIEGGFIPPTINHV
                     STDPDCDVDCVPNQAITADLQIVQNNGLAFGGNNAVVMLG"
     aSModule        1573..2532
                     /domains="nrpspksdomains_ctg1_1_PKS_KS.1"
                     /incomplete
                     /iterative
                     /locus_tags="ctg1_1"
                     /tool="antismash"
                     /type="pks"
     CDS             2556..3677
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (128-372). E-value:
                     1.9e-40. Score: 130.8. Matches aSDomain:
                     nrpspksdomains_ctg1_2_PKS_KS.1"
                     /NRPS_PKS="type: PKS/NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 195.7; E-value:
                     2.2e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_2"
                     /sec_met_domain="APE_KS2 (E-value: 3.5e-54, bitscore:
                     174.2, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIDFTGRGVITSVGTGVTNLFDNLCLGQVGVKELQAFDPRPFRA
                     KLAYELADRPNGRDRMARASELLLKVLHQAIDEAGLTDITHAPVIVGTGLRELRSLELW
                     WRGQGDLTPAGLNFGSAIRQEFGARSYTVSNACAAGLSALTIGADLLALDEADTVVVAG
                     VDVLTESMHGLLERVHEQAPSRVQPFDRHRKGVLMGDGAAAVVLQCSSSGQRSLGRLRA
                     TASNCDAFHVTAPESEGIAAAIEDAHRSARVDPGDVDLVMLHGTGTLLNDEAEATAMRS
                     VFADKVAQPHMTAIKSMTGHTSGASGVVGLVMGLECLARQTVLPTVGLNEPSDEAHDFR
                     LSPSAVHTSLHIAQVNAFGFGGVNTVAIVEVAE"
     aSDomain        2940..3671
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_2_PKS_KS.1"
                     /evalue="1.90E-40"
                     /label="ctg1_2_PKS_KS.1"
                     /locus_tag="ctg1_2"
                     /protein_end="372"
                     /protein_start="128"
                     /score="130.8"
                     /tool="antismash"
                     /translation="RSYTVSNACAAGLSALTIGADLLALDEADTVVVAGVDVLTESMHG
                     LLERVHEQAPSRVQPFDRHRKGVLMGDGAAAVVLQCSSSGQRSLGRLRATASNCDAFHV
                     TAPESEGIAAAIEDAHRSARVDPGDVDLVMLHGTGTLLNDEAEATAMRSVFADKVAQPH
                     MTAIKSMTGHTSGASGVVGLVMGLECLARQTVLPTVGLNEPSDEAHDFRLSPSAVHTSL
                     HIAQVNAFGFGGVNTVAIVEVAE"
     aSModule        2940..3671
                     /domains="nrpspksdomains_ctg1_2_PKS_KS.1"
                     /incomplete
                     /iterative
                     /locus_tags="ctg1_2"
                     /tool="antismash"
                     /type="pks"
     CDS             3674..4597
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MTNITITGSGLALPVARDPQLLVDIILSASPDDAPCVDVDPIAWL
                     GKRKGLRYKDRATQLAYCAASDALKSAGLLIEDGLTVDACDIAVVGTSNFGNLDTVTST
                     IDILSAEDTTSTSPMDLPNASSNVLASSVAVRYGLKGPNLMLCNGATSGTDALMVASTL
                     LRAQRARHVVVVGAEPDNKPIQRLISGRGANAGAAIVMETSDTAIDRGARMQAQLERVT
                     PSIGVDSWQGLSHADETVVIGGPLTTSDDSTFTVTLPRAWGDMSGMLGVLQAVLAGALL
                     ERRPTARVLTHTGDSTATVGASFVAP"
     CDS             4609..5448
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262:haloalkane dehalogenase (Score: 39.3; E-value:
                     7.4e-12)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.2e-17, bitscore:
                     53.7, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 3e-07, bitscore: 20.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGRHLRSACYRPADSIIFHEYGRLEEHAETLVLLHGLANNAKAW
                     RPMLTRLDGERVLVADLPWRGDMIAGGAPYDDYEDALRQSILEAGGPAIVVAHSFSSLL
                     LLSMLHRHFEAGRDPLSELLIRALVLVAPFYRNDPRMFVWGDLERYLNDFWTIMREGIV
                     ISSPRRIDEDVLAGMAIYVRDQVGTYGWLRFIDAYLSTPWLNLERFDLPVLVVSGELDE
                     TAPPCEANLLAEHLPNARRAVIANAGHFPMSDSPQSLTDSIHHFLQEIRTTSGRTAR"
     CDS             5445..6437
                     /locus_tag="ctg1_5"
                     /transl_table=11
                     /translation="MTPVKSLVMPLLEGTSKTTVRPRYEGNNICTWIGFKHVNYMVEDA
                     ILQHFRFAGLSSRRLFEDYALGLDIVSIDTRILNAFHLDDEATATITAKGLNDKGRLSF
                     TVMMSRGGKTVDVSSKVEVALRREDFVGGPHAANEELDALTVARIATAEPGDHVKPAAQ
                     PSLSLERGTHGNDPVLAYLTEGRNAFGWRWRIPYFYCHNNERLQMSGYLRNMEEIVDLF
                     LANRGISIKTLLDDRRWIPVVPHSHIEFLDEALIEEDLYMVYTVEDIFKEFTYRSRMDA
                     YVVRDNRLIQVATGTITHGYALIDSRTDWHLVPFDERVMNAFKDGAAAS"
     CDS             6434..6817
                     /locus_tag="ctg1_6"
                     /transl_table=11
                     /translation="MTKTFASLDYVTLRDDPSATSGLLTVLGLGPWDGQGAVLPLEGMR
                     AVMRAGSNATLFLAGDGVAWAVPTPRAEITELAELGATVMVDQWSARQRGLDDLGDSER
                     ISWASPIDIAGLVADPDTTVVWR"
     CDS             6817..7224
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MARQVPATDVMLTLVASPHRDDTVTHVLRTVVALLENGRKVGVWA
                     CGYATTLTSGGLGASKPRDLASWDTDYPSTATIVADLLEAYDGSLYWYACRFCSDDRGV
                     ERHIDGVVSRAPSRFRNHVAASAKCLIVGGL"
     CDS             7226..7606
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MAAQALAILDRVHRGAVEKQFFSPLYLAIEMHHQLGGLDLLVCGP
                     AVVAVISQAVAEPLTFGSRLLTSLPNPHAEIHRLLEEGVQVFVDRTDLRTFAGVDPDSR
                     ISIVDRAQVMSNLASYSTAFYL"
     CDS             7614..8666
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 58.3; E-value:
                     1.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MQTQPSNRLIIRRWSAVSPYGIGAQAFIDGLREGAATERPLMYDE
                     GPYRSAHLVPDFSPALALGKKGTRSMDRATALAVTTVRELLDGLPESLVGDRPGLVLGT
                     TTGSASSMMEFTRDSLTGQRPFFVDPARFPNTVMNCAAGQCAIWHNLTGPNATVAGGRL
                     SAFHALNYAKRLIRTRRASSIIAAAVEEYSTARAWLEAVQGQSRLLGEGCGALLVTDDT
                     RTDSDLDDVEVEVLSVQLGVSLDSSKAALTRLIHRTLEQAGLTAADVDAVSFTDTDNES
                     QVAAAAAVLGTDFTVVPPVEAGDCGAAAGALGLVATVNHLTSQECPTTVLTVCTEDEEQ
                     AVGCALLRLA"
     CDS             8776..9036
                     /NRPS_PKS="Domain: PP-binding (10-72). E-value: 1.1e-14.
                     Score: 46.5. Matches aSDomain:
                     nrpspksdomains_ctg1_10_PP-binding.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_10"
                     /sec_met_domain="PP-binding (E-value: 2.9e-15, bitscore:
                     46.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEFTPFDREDLRATVARVLEVDVEEVTDTASFVDDLGADSLIGL
                     EVIVVLEKRYGVKLTESALRNITCLDDAYRQLDADLRTARP"
     aSDomain        8806..8991
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_10_PP-binding.1"
                     /evalue="1.10E-14"
                     /label="ctg1_10_PP-binding.1"
                     /locus_tag="ctg1_10"
                     /protein_end="72"
                     /protein_start="10"
                     /score="46.5"
                     /tool="antismash"
                     /translation="DLRATVARVLEVDVEEVTDTASFVDDLGADSLIGLEVIVVLEKRY
                     GVKLTESALRNITCLDDA"
     aSModule        8806..8991
                     /domains="nrpspksdomains_ctg1_10_PP-binding.1"
                     /incomplete
                     /locus_tags="ctg1_10"
                     /tool="antismash"
                     /type="unknown"
     CDS             9033..9395
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MTTAYLRSIYIPSAGSPEGTTSIFITPQDEIFRGHYPEFAILPGV
                     ALVELSRRAVIAHLGLSSNEPIAEIESARFRGPVFPGDEVGLHVEMFGDQRARATITCC
                     GSNVASVRLRLQRKTA"
     CDS             9392..9910
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1270:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine
                     (Score: 66.6; E-value: 3.7e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MITVESIAARLPHRYPMLLIDSVSEIEISQGLVAHKAITANEPWY
                     AGLEESAQPSDWMYPQSLLLESWCQAASLLATWEAPNPSVAEGRVMLFGGMSSVLFEEP
                     VMPGCVLEHRVRVQRALPDTLLVEGECMTGAKLVLSVGSVVLALRPAAELRPTDAKPRL
                     ANAEIRREP"
     CDS             9907..10653
                     /NRPS_PKS="Domain: PKS_KR (8-169). E-value: 5.3e-20. Score:
                     63.8. Matches aSDomain: nrpspksdomains_ctg1_13_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     246.2; E-value: 5.7e-75)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_13"
                     /sec_met_domain="adh_short (E-value: 6.3e-39, bitscore:
                     123.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2.8e-35, bitscore:
                     112.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADTRPVAFVTGGNRGIGAAIVETLARDGYDVVLTYSTNADAAQ
                     AVTEEAVSHGGRCLAVQVDVRNADVVSSAFRQVLDDFGVPEVVVANAGITKDNPLLMMS
                     NADWRDVLDVNLTGVYTVCRAAVFDMMKRRRGAIITMSSVAGVYGSATQTNYAASKAGI
                     IGFSRSLAKEVAPYGIRVNTVAPGFIESDMTSQLSDEVRTRSLAAIPFKRFGMPQEVAD
                     VVAFLASDRASYITGSVVQVDGAIAI"
     aSDomain        9931..10413
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_13_PKS_KR.1"
                     /evalue="5.30E-20"
                     /label="ctg1_13_PKS_KR.1"
                     /locus_tag="ctg1_13"
                     /protein_end="169"
                     /protein_start="8"
                     /score="63.8"
                     /specificity="KR stereochemistry: C2"
                     /specificity="KR activity: inactive"
                     /tool="antismash"
                     /translation="AFVTGGNRGIGAAIVETLARDGYDVVLTYSTNADAAQAVTEEAVS
                     HGGRCLAVQVDVRNADVVSSAFRQVLDDFGVPEVVVANAGITKDNPLLMMSNADWRDVL
                     DVNLTGVYTVCRAAVFDMMKRRRGAIITMSSVAGVYGSATQTNYAASKAGIIGFSRSL"
     aSModule        9931..10413
                     /domains="nrpspksdomains_ctg1_13_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg1_13"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       9937..9993
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_13_0001"
                     /evalue="6.70E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_13"
                     /protein_end="29"
                     /protein_start="10"
                     /score="12.4"
                     /tool="antismash"
                     /translation="VTGGNRGIGAAIVETLARDG"
     CDS_motif       10321..10380
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_13_0002"
                     /evalue="7.80E-07"
                     /label="PKSI-KR_m4"
                     /locus_tag="ctg1_13"
                     /protein_end="158"
                     /protein_start="138"
                     /score="21.6"
                     /tool="antismash"
                     /translation="ITMSSVAGVYGSATQTNYAAS"
     CDS             10664..11368
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MTKQPDRWYFSFRSPYSWLAYRDLSRMRGDLLESLEWRPFFEPGP
                     QLRSALKDRGRAIPYVPMSKEKHLYILQDVHRLAAERGLVNVWPLDNCPCWETSHLAWF
                     VAADAGRSRDYVDAIYEARWERSENISDPQTIRRVGERIGLNPEALAGAASDPEMQARG
                     LAALMAVCDDQVFGVPMFITGRDRYWGLDRVQAFAAVVDVASGKASTAGAVPPGRDPPD
                     GAGGRGHELRAAA"
ORIGIN
        1 cccggacgca ggccgcatca acctggtggg tgctgcgcac ccacccagtt cgtggggatg
       61 gtcagcactg gttgaccgcc ccgaggatgt ggatgatcgt agggtcccag ggcactggga
      121 gggtgacctg atcatcggga accgatggca cctcagcggc agcgaccctg gtagagcgca
      181 ccacccggtt cgtgacgatc ctggctctac ccgttgggga aggaacatct gagggtttgt
      241 gtgatgtgtt gatcgatcac atcaacacca tcccagatgt gatgcggggt tccttgacct
      301 gggatcacgg ttgcggagat gcacctgtca tgccgcgctc accctggcaa ccgacatgaa
      361 gatgtgtctt cgtctcgtcc tcgttctcca tgggaacggg gaaccaacga gaacacaggc
      421 gggctgaatc tgtgagtacc tacccaaagg cacccagatc accacacacc agccctacca
      481 caggcgccat cgccgaagag ctcaatgaac gccccagagc agccctggga tggctcaccc
      541 cacgcgaagc atacgaacgc ctactcgttg cttccaccac ttgacaccaa gagcaactat
      601 ctacgggaca caccactaga tgcatgctca cgtcgggtac tgggctgggc gatagatccc
      661 taccaaatac agcgacctag tcaaacgcgc gttgaccatg gcccaccccc cacgcggcaa
      721 actacccggc caagtcgtgt tccattccga tcgcggcacc cagagcacac ctccaagcag
      781 ctgtggcgag cctgcagcag actcaccata gaccagtcca cgggagccat cggagtgcgc
      841 tgcgacaaca cgatgaccga ataattcttt gctacgttga aaccgagttc taccaccgcc
      901 accactggcc aacccggacc gaagcccgca ccaaggtcac tcgccggatc gaggtcgact
      961 acaaccctcg ctggcaccac tccgcgttgg gctatcagcc actagtcgag ttcgagcagc
     1021 accacacaac gaggcttaat tcacaggcga cgcattcgct agcaaaatcc ctagtcagag
     1081 tgggtttgag ggaggctatg aattaagccg caacaattaa atgctcaact aggaagcagg
     1141 ccatgtgggc cggacgtgcc cacaatttgc agacaaatcc aggggaaatt tcgtgaggca
     1201 agggcccctc ctgcgcgggg agtcttcgcg agtatcaccg gaggggttgc cagggacctc
     1261 gcgcaactgg tagcctcatt cttaaaccgc aacgcacatg gaccaagatt gagaacttct
     1321 atgcagacaa tgtccagcga ttcggaacgg gtcgtgataa ctggccttgg tgttatatct
     1381 agcatcggaa ccgggacgga agcttttgct cgggctctcc gtgctggcgc tagtggagac
     1441 cgggcaatca gcatgtttga caccaccgga tatgattacg ccaacggttg cgaagtcgtg
     1501 gatttcgccc ccaaagagca cctgtcagcc cccgagctag atacccttgg gcgagccacc
     1561 cagttctctg tggccgccgc agttatggcg attaaagact cgggtttccc gatagaccag
     1621 ttgcgaagtc ggcgaggcgt gatctcgatc gggaccaccg acggagagtc tcaagacctt
     1681 gaccggcttg cagaaacatg ggaggtagca ggaccatccc agatgaatcc taccgctgcc
     1741 aaacgagtcc cggcgggtcg actctccatc gccatcgcgg aacacctcgg tcttgacgac
     1801 gtagaggctg tcacacttcc cactgcgtgc gcggcaggga actacgcgat cggttacgga
     1861 ctcgacgcca tccgcacagg cgaagccgaa tatgcgctgt gtggcggcgc cgacgccatg
     1921 tgccgcaaga catttaccgg cttttaccgc ttgggcacca tcgcacccga gaagtgccag
     1981 ccattcgacg tgaaccgcaa gggcatccta acgggtgagg gcgctggtgt gctactgatc
     2041 gagtcattga agtcggcgcg tagccgcggc gcacgcatcc acgccgaagt ccttggttat
     2101 gggctcacgt gcgatgctta ccatcaagtc gctcctaagg cttccagcgt ctcgcattgc
     2161 atcgaactag ccctcgaaga cgccagtatt aggccatcag aggttgacct catctccgct
     2221 catggcaccg ggacacgggc taatgacgtg accgagtgcg cggcgatccg agacattttt
     2281 ggttcagagc ctcctcgcgt ggtctcggtc aagtccatga tcggccacac catgggcgcc
     2341 gccagcgccc tcggcgctat cgcgtgttcg ctggccatcg aaggcgggtt catcccgccg
     2401 acgatcaatc atgtcagcac agatcccgat tgcgatgtgg attgcgtgcc aaatcaagcg
     2461 atcaccgcgg accttcagat cgtccagaac aacgggttag ccttcggcgg taacaacgcc
     2521 gtggtcatgc tcgggaagtg cgcgaggtga gccacatgcc tattgacttc accggccgcg
     2581 gcgtcatcac gagcgtcggc accggcgtga ctaacctttt cgacaatctg tgtctaggtc
     2641 aagtgggagt caaagagctc caggcatttg atccccggcc gtttcgcgcc aagctagcct
     2701 acgaactggc ggaccgcccg aatggccgcg atcgcatggc gcgagcctct gagcttctcc
     2761 tgaaggtgct ccaccaggct atcgacgagg cgggattgac cgacattact cacgcgccag
     2821 ttatcgtggg taccggcctg cgcgagttgc gctccctcga gttgtggtgg cgtggacaag
     2881 gagatctgac gccagccgga cttaacttcg gatcagctat ccggcaagag ttcggtgcgc
     2941 gctcgtacac ggtgtcaaat gcctgcgcgg ctggcctctc agcactcact atcggtgcgg
     3001 acttgctcgc cctcgacgag gcggacaccg tcgtcgtcgc cggagtggac gtgctgactg
     3061 agagcatgca cggtctgctt gagcgggtcc acgagcaggc tccgagccgt gtgcagccct
     3121 tcgaccggca ccgcaagggc gtactcatgg gtgacggcgc ggcagcggtc gtcctccaat
     3181 gctcttcgag cggccagcgt tctctcgggc gtcttcgcgc gacggcctcc aactgcgatg
     3241 cctttcatgt aactgccccg gagagtgaag ggatcgctgc tgcgatcgaa gacgcgcatc
     3301 gctccgcgcg ggtcgacccc ggcgatgtcg acctagtaat gctccacggc acgggcaccc
     3361 tgctcaacga tgaggccgag gcaacggcca tgcgcagcgt cttcgcggat aaggtggccc
     3421 agccccatat gactgcgatc aagtccatga cgggccacac ctctggagcc tccggtgtcg
     3481 tcggcctcgt catgggactg gaatgtctcg cccgccaaac cgtccttccc acggtaggcc
     3541 tgaatgaacc ctcggacgag gcgcacgact tccgtctctc cccctctgca gtgcacacct
     3601 cgctgcacat tgcccaagtc aacgcttttg gatttggggg cgtcaacacc gtcgccattg
     3661 tggaggtggc agaatgacca acatcacgat caccggttcg ggtcttgcct tgccagtggc
     3721 acgagatcct cagctcctag tcgatatcat cctatcggcc tctccggacg acgcgccctg
     3781 cgtggacgtc gatccgatcg cgtggctggg gaagcgcaag ggccttcgct ataaagaccg
     3841 cgccacccaa ctcgcctact gtgcagcgtc ggatgctctc aagtccgctg ggctcctgat
     3901 cgaggatggc ctcaccgttg atgcctgcga catcgccgtg gtcggaacct ctaacttcgg
     3961 taacctcgat accgtgacca gcacgatcga cattctctca gcagaggaca cgacatcaac
     4021 cagtcctatg gatctgccga acgcatccag caacgtgctc gcttcctccg tggcggttcg
     4081 gtatgggctg aaaggcccga acctcatgct gtgcaacggc gcaacatctg gtactgacgc
     4141 gctcatggtg gcgtcgactc tccttcgcgc gcagcgagcc cgtcatgtcg tcgtggtggg
     4201 cgccgagcca gacaacaaac ccatccaacg actcatcagc ggtcgaggcg ctaatgctgg
     4261 cgctgcaatc gtgatggaga ccagcgacac cgccatagat cgtggagcgc gtatgcaggc
     4321 gcagctagag cgcgtcacgc cgagcatcgg tgtggattct tggcaggggc tatctcatgc
     4381 cgatgaaacg gtcgtcatag gcggacccct caccactagc gatgactcca ctttcacagt
     4441 tacacttccg cgggcttggg gcgacatgtc agggatgttg ggagtcctcc aggccgtcct
     4501 tgcaggtgcc ctgcttgagc gcaggccaac ggcacgcgtc ctcactcaca ctggcgactc
     4561 caccgctacg gtcggcgcgt ccttcgtcgc accatgagca cgccggcgat ggtcggacgc
     4621 catctacgct cggcgtgtta ccgtcctgct gactccatca tctttcacga gtacggcaga
     4681 ctcgaagaac acgccgaaac cctcgtgttg ctccatggtc tcgccaacaa cgccaaggcg
     4741 tggcgcccca tgctcactcg tctcgatggg gagcgagtgc tggttgccga cctaccttgg
     4801 cggggggaca tgatcgccgg tggggctccg tatgacgact acgaggacgc cctacggcaa
     4861 tccatccttg aggcgggcgg ccccgccatc gtcgtggcgc attcgttttc cagcctgcta
     4921 ttactgtcga tgctccatcg ccacttcgaa gcaggccgtg acccgctctc agagctgctt
     4981 atccgagctc tcgtgctagt cgctcccttc tacaggaacg acccgcgtat gtttgtatgg
     5041 ggcgacctcg aacgctacct gaacgacttc tggacgatca tgcgcgaggg aattgtcatc
     5101 agcagccccc gcagaatcga cgaggatgtg ctcgcgggca tggcgatcta cgtccgggac
     5161 caagtcggca cctacggatg gctgcggttt atcgacgcct acctgtcgac cccctggtta
     5221 aacctcgagc gattcgatct ccccgttctt gtcgtcagcg gggaactaga cgaaacggcc
     5281 cctccctgtg aggccaatct ccttgccgaa cacctgccaa acgcccgccg cgcggtcata
     5341 gcaaatgccg gtcacttccc gatgtccgac tccccgcaaa gcctcaccga ttcaattcat
     5401 cactttctcc aggaaatccg cactacttcc ggaaggactg cacgatgact cctgtcaaga
     5461 gccttgtcat gcccctgctc gaggggacca gcaagaccac cgtccgcccc cgctacgagg
     5521 gcaacaatat ctgcacatgg atcggtttca agcacgtgaa ctacatggtc gaggatgcga
     5581 tcctccagca cttccgcttc gcgggcctct ctagccgcag gcttttcgag gactacgctc
     5641 tgggcctcga tatcgtctcg atcgacaccc gcattcttaa cgctttccat ctcgacgacg
     5701 aggcgaccgc caccatcacg gccaagggac tcaacgacaa gggtcggctg agcttcaccg
     5761 tcatgatgtc ccgggggggc aagaccgtcg acgttagcag caaagtcgag gtggcgctgc
     5821 gcagggaaga cttcgtaggc ggcccccacg ccgccaacga agagcttgac gcgctcaccg
     5881 ttgcccggat cgccacggca gagccgggcg accacgtcaa gcccgcggca caaccctccc
     5941 tgtccctaga gcggggcacc cacggcaacg accccgtgct cgcttacctc accgagggtc
     6001 gcaacgcttt cggctggcgc tggcgtatcc cttacttcta ctgccacaac aacgagcgtc
     6061 tgcagatgtc ggggtacctg cgcaacatgg aagagatcgt ggatcttttc ctcgcaaacc
     6121 gcggtatctc catcaagacg ctgctcgacg accgtcgctg gatcccggtc gttccccact
     6181 cgcacatcga gttcctcgac gaggccctca tagaagagga cctgtacatg gtctacacag
     6241 tcgaggacat cttcaaggag ttcacttacc gctcgcgtat ggacgcgtat gtcgtgcgcg
     6301 acaaccgact tatccaggtt gctaccggca ccattaccca cgggtacgcc ctcatcgact
     6361 cgcgcactga ctggcacctc gtgcccttcg acgaacgcgt catgaatgcc ttcaaggatg
     6421 gggccgccgc gtcatgacaa agaccttcgc cagtcttgat tacgtgacgc tgcgtgacga
     6481 cccctccgcc acatctggtc tactcaccgt cctagggctc gggccttggg acgggcaggg
     6541 tgccgtcttg ccgctggagg gtatgcgcgc cgtcatgcgc gcgggatcga acgccacact
     6601 ctttctcgcc ggagatggcg tggcttgggc tgtacctaca ccccgtgccg agatcacgga
     6661 gctcgccgag ctcggtgcca ccgtcatggt cgatcaatgg tcagcacggc agcgaggttt
     6721 agatgattta ggtgattctg agagaatcag ctgggctagt cccatcgaca tcgcaggcct
     6781 cgtggccgac ccagacacca cggtggtgtg gcgttgatgg cccgacaagt accagcaacg
     6841 gacgtcatgc taactttggt agcctcaccc catcgggacg acaccgtcac gcacgtcctg
     6901 cgcaccgtgg tggctcttct ggaaaacggc cgcaaggttg gagtttgggc atgtggttac
     6961 gcgaccacct tgacatcggg cgggttggga gcatccaaac ctcgcgatct cgcctcatgg
     7021 gacaccgact acccatcgac cgcgacgatc gtcgcggacc tactggaagc gtatgacgga
     7081 tctctctatt ggtacgcctg tcgcttctgc agcgacgacc gaggcgtcga gcgacacatc
     7141 gatggggtcg tttctcgggc gccttcgcgc ttcagaaacc acgtggcggc cagcgccaag
     7201 tgcctcatcg tcggagggct ttagaatggc cgcccaggca ctcgccattc tcgaccgagt
     7261 ccatcgaggt gcggtcgaga agcagttctt cagccctctg tatctcgcca tcgagatgca
     7321 ccatcaactt ggcgggctcg accttttggt atgcgggccg gctgtcgtgg cagtcatcag
     7381 ccaagctgtc gccgagcccc tgacgttcgg cagccgtttg ctcacgtctc tgcccaatcc
     7441 tcatgccgag atccatcggt tgctcgagga gggagtgcaa gtcttcgtcg accgcacaga
     7501 tctgcgcacc ttcgcgggcg ttgaccccga ttcccgcatc tcgatcgtcg atcgggccca
     7561 agtcatgtcc aacctcgcgt cctactccac tgccttctac ctctgaggaa gcaatgcaga
     7621 ctcaacccag taaccgtctt ataatccggc gctggtccgc cgtatcaccc tatggaatcg
     7681 gagcgcaagc cttcatcgat gggctccgag agggggcagc gaccgaacgt ccgttgatgt
     7741 atgatgaagg gccgtatcgc tcggcgcact tggtccccga tttctcaccc gcattagccc
     7801 tcggcaaaaa gggcactcgc tccatggacc gggcaacggc cttggcggtc accacggtcc
     7861 gtgaactcct cgatggactg cccgagagtc tcgtcggtga tcgtcccggg ctagtgctcg
     7921 gcaccacgac cggcagcgct tcctcgatga tggagttcac gcgcgactcc ctcaccgggc
     7981 agcgtccgtt cttcgtggac cctgcccggt tccccaacac cgtgatgaac tgtgccgctg
     8041 gtcagtgcgc catctggcac aacctcacag gccctaacgc cacagtggcc ggtggccgac
     8101 tttccgcctt ccacgcgctc aactacgcca agcgactcat tcgcacccgt cgagccagca
     8161 gcatcatagc tgcagccgtc gaggaatact ccaccgcacg cgcttggctt gaggccgtgc
     8221 agggacagtc ccgtctcctc ggggagggct gcggcgccct gcttgtaacg gatgacacca
     8281 ggaccgactc cgaccttgac gatgttgaag tcgaagtgtt atctgtgcaa ctaggggttt
     8341 ctctcgactc atccaaagcg gcgcttactc gactcatcca ccgtaccctc gagcaggctg
     8401 gcctgaccgc cgcagatgtt gacgccgtgt ccttcaccga taccgataac gagagtcagg
     8461 tggctgcagc ggcggccgtc ctcgggacgg atttcaccgt tgtcccacct gtcgaggctg
     8521 gtgactgcgg ggctgcagcc ggtgccctgg gacttgttgc tacggtcaat cacctgacct
     8581 cccaggagtg cccgaccacc gtcctcacgg tctgcaccga agacgaagaa caggccgtcg
     8641 gctgcgctct gctgcgcctc gcctgagacc ctgagccagt cagcgcaccg accgaaagca
     8701 tgccataccc gcccgagcgc tagctcgaca ccccgcacta ccgaacgaca gatcaaccac
     8761 cgaagggata tccacatgcc cgaattcaca ccgtttgacc gggaagactt gcgcgctacc
     8821 gtcgcacgag tcctagaggt cgatgtcgag gaagtcacag atactgcatc cttcgtcgac
     8881 gatctgggag ccgactccct tataggcctc gaagtaatcg tggtgctgga gaagcgttac
     8941 ggagtcaagc tcaccgaatc ggccctgcgc aacatcacat gcctcgacga cgcctaccgc
     9001 cagctagacg ccgacctaag gacggcccgc ccatgacgac cgcatatctt cgcagcatct
     9061 acataccaag cgccgggtcg ccggagggca cgaccagcat cttcatcacg ccacaagacg
     9121 agatcttccg ggggcactac cccgagttcg ccatcctccc tggtgtggca ctcgtcgagc
     9181 tgtcccgccg cgctgtcatc gcgcacctcg gactaagcag caacgaaccg atcgcggaaa
     9241 tcgagtccgc ccggtttcgc ggcccggtct tccccggtga cgaggtgggc ttgcacgtcg
     9301 aaatgttcgg ggaccagcgc gcgagggcca cgatcacttg ctgcggaagt aatgtcgcat
     9361 ccgtccgcct tcgtcttcag aggaaaaccg catgatcacc gttgaatcca tcgccgcgcg
     9421 gcttccgcac cggtatccga tgttgctcat cgattccgtg agcgagatag agatcagcca
     9481 agggctcgtc gcgcacaagg cgatcaccgc caacgagccc tggtatgcgg gtctcgagga
     9541 atcggcacaa ccctcggatt ggatgtaccc ccaatcgctt ctcctggagt cttggtgcca
     9601 agccgcatca ctcctcgcaa cgtgggaagc ccccaaccca agcgtggctg agggacgcgt
     9661 catgctattt ggcggcatga gcagcgtcct tttcgaggaa cccgtgatgc cggggtgcgt
     9721 cctagaacac cgagtgcgcg tacagcgcgc tctgccggac acgctccttg tcgagggcga
     9781 gtgcatgaca ggggccaaac tggtcctatc cgtcggcagc gtcgtactgg cccttcgccc
     9841 cgcagctgaa cttcgaccga ccgatgccaa gccgcgactg gctaacgccg agatacggag
     9901 ggaaccatga gcgccgatac gcgcccggtc gccttcgtca ccggaggcaa tcgcggtatt
     9961 ggggcggcga tcgtggagac acttgcacgg gacggttatg atgtcgtgct cacctactcc
    10021 acgaatgccg acgccgccca agcagtcact gaggaagcgg tcagccacgg cggtcgctgt
    10081 ctagcggttc aagtggacgt ccgaaacgcg gatgtcgtga gttcggcgtt caggcaggtc
    10141 ctcgacgatt tcggagtccc agaggtggtc gtcgccaacg cgggcatcac caaagacaac
    10201 ccgctgctca tgatgagcaa tgctgattgg agagatgttc tcgacgttaa tctcaccggc
    10261 gtttatacgg tctgtcgggc cgcggttttc gacatgatga agcgccgcag gggggccatt
    10321 atcaccatgt cgtccgtagc aggcgtgtac ggcagcgcca ctcagacaaa ttacgcagcg
    10381 tcaaaggctg ggataattgg cttttctcgg tcgctggcca aagaagttgc cccttacggc
    10441 atccgggtca acacggtagc ccccggtttt atcgagtcgg acatgacgtc acagctgagc
    10501 gacgaagtcc gcactcgttc cctcgcggcc atcccgttca agcgtttcgg gatgccacaa
    10561 gaggtggcgg acgtggtggc cttcctcgca tctgatcgcg catcgtacat cacagggtcc
    10621 gtggtccagg tcgacggcgc catcgccatt tgaggggacg acgatgacga agcaaccaga
    10681 ccggtggtac ttttcattcc gaagccccta ctcgtggctg gcataccggg atctcagtcg
    10741 catgcgaggg gatctgctcg agagtcttga gtggcggcct ttcttcgaac cgggaccgca
    10801 actgcgcagc gccctgaagg acaggggcag ggccattccg tacgtcccca tgtccaaaga
    10861 gaagcaccta tacatcctcc aggacgtgca tcgcctcgcc gccgagcgtg ggctagtcaa
    10921 cgtatggcca ctcgacaact gcccctgttg ggagacctcc catttggcgt ggttcgtcgc
    10981 cgccgacgca ggtcgctccc gcgactacgt cgatgccatc tacgaagctc gctgggagcg
    11041 cagcgagaac atttcagacc cgcagaccat tcggcgcgtt ggtgagcgta ttggcctgaa
    11101 tccagaggcg ttggctggcg cagcttcgga tcctgagatg caagccagag gactcgcagc
    11161 cctgatggct gtctgcgatg accaggtctt tggggtccct atgttcatca ccggtcggga
    11221 ccgctactgg ggtctagatc gtgttcaggc cttcgccgct gtggtcgacg tggcttcggg
    11281 taaagcatcc actgcaggcg cggtgccccc gggccgtgac ccgccagacg gcgccggcgg
    11341 gcggggccac gaactccggg cggccgcgag
//
