LOCUS       c00003_3300007..       13810 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300007348.a:Ga0104342_100118.
ACCESSION   c00003_3300007..
VERSION     c00003_3300007..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 14:55:25
            Original ID  :: 3300007348.a:Ga0104342_100118
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13810
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13810
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1479:3810](+)"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C) or cds(LANC_like and (Pkinase or DUF4135)))
                     and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1480..3810
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C) or cds(LANC_like and (Pkinase or DUF4135)))
                     and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13810
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C) or cds(LANC_like and (Pkinase or DUF4135)))
                     and not (YcaO or TIGR03882))"
                     /kind="single"
                     /product="lanthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13810
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C) or
                     cds(LANC_like and (Pkinase or DUF4135))) and not (YcaO or
                     TIGR03882))"
                     /tool="antismash"
     CDS             2..85
                     /locus_tag="ctg3_1"
                     /transl_table=11
                     /translation="TDGRVIEVGQHVYRPSLYSFHFSLFTS"
     CDS             complement(132..299)
                     /gene="allorf_00132_00299"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_00132_00299"
                     /protein_id="allorf_00132_00299"
                     /tool="antismash"
                     /transl_table=1
                     /translation="VFLVSLEDFPATGCRFGYQGLSAFSCARLDGDVFWAGERAVCRKA
                     SGKKVHPAHG"
     CDS_motif       complement(192..299)
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     VFLVSLEDFPATGCRFGYQGLSAFSCARLDGDVFWA"
                     /tool="antismash"
                     /prepeptide="leader"
                     /locus_tag="allorf_00132_00299"
                     /aSTool="lanthipeptides"
     CDS_motif       complement(132..191)
                     /molecular_weight="1970.3"
                     /leader_location="[191:299](-)"
                     /leader_sequence="VFLVSLEDFPATGCRFGYQGLSAFSCARLDGDVFWA"
                     /locus_tag="allorf_00132_00299"
                     /predicted_class="Class II"
                     /tool="antismash"
                     /peptide="lanthipeptide"
                     /score="-7.00"
                     /monoisotopic_mass="1969.1"
                     /core_sequence="GERAVCRKASGKKVHPAHG"
                     /aSTool="lanthipeptides"
                     /prepeptide="core"
     CDS             complement(376..462)
                     /gene="allorf_00376_00462"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_00376_00462"
                     /protein_id="allorf_00376_00462"
                     /tool="antismash"
                     /transl_table=1
                     /translation="LCFLRAEVVTNLNTDLGSCNSLNLPLGE"
     CDS_motif       complement(409..462)
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: LCFLRAEVVTNLNTDLGS"
                     /tool="antismash"
                     /prepeptide="leader"
                     /locus_tag="allorf_00376_00462"
                     /aSTool="lanthipeptides"
     CDS_motif       complement(376..408)
                     /molecular_weight="1041.2"
                     /leader_location="[408:462](-)"
                     /leader_sequence="LCFLRAEVVTNLNTDLGS"
                     /locus_tag="allorf_00376_00462"
                     /predicted_class="Class II"
                     /tool="antismash"
                     /peptide="lanthipeptide"
                     /score="-6.10"
                     /monoisotopic_mass="1040.5"
                     /core_sequence="CNSLNLPLGE"
                     /aSTool="lanthipeptides"
                     /prepeptide="core"
     CDS             521..676
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_2"
                     /sec_met_domain="L_biotic_A (E-value: 1.4e-22, bitscore:
                     71.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKYNDEIIDNLAEMTDTEIEELLGAGRGVVPTVTHECHMNSWQ
                     WFFGCC"
     CDS_motif       521..601
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKKYNDEIIDNLAEMTDTEIEELLGA"
                     /tool="antismash"
                     /prepeptide="leader"
                     /locus_tag="ctg3_2"
                     /aSTool="lanthipeptides"
     CDS_motif       602..676
                     /molecular_weight="2728.1"
                     /leader_location="[520:601](+)"
                     /leader_sequence="MEKKYNDEIIDNLAEMTDTEIEELLGA"
                     /locus_tag="ctg3_2"
                     /predicted_class="Class II"
                     /tool="antismash"
                     /peptide="lanthipeptide"
                     /score="0.40"
                     /monoisotopic_mass="2726.2"
                     /core_sequence="GRGVVPTVTHECHMNSWQWFFGCC"
                     /aSTool="lanthipeptides"
                     /prepeptide="core"
     CDS             complement(1005..1130)
                     /gene="allorf_01005_01130"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_01005_01130"
                     /protein_id="allorf_01005_01130"
                     /tool="antismash"
                     /transl_table=1
                     /translation="LGARFRICCESASPSACSIIMGKGIVGADCICVMAVSNERI"
     CDS_motif       complement(1047..1130)
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: LGARFRICCESASPSACSIIMGKGIVGA"
                     /tool="antismash"
                     /prepeptide="leader"
                     /locus_tag="allorf_01005_01130"
                     /aSTool="lanthipeptides"
     CDS_motif       complement(1005..1046)
                     /molecular_weight="1434.7"
                     /leader_location="[1046:1130](-)"
                     /leader_sequence="LGARFRICCESASPSACSIIMGKGIVGA"
                     /locus_tag="allorf_01005_01130"
                     /predicted_class="Class II"
                     /tool="antismash"
                     /peptide="lanthipeptide"
                     /score="-4.60"
                     /monoisotopic_mass="1433.7"
                     /core_sequence="DCICVMAVSNERI"
                     /aSTool="lanthipeptides"
                     /prepeptide="core"
     CDS             complement(1138..1467)
                     /locus_tag="ctg3_3"
                     /transl_table=11
                     /translation="VDIAQWLNGDHTRASVKMVCFQELGERGGILCDTSQDRFESRSQG
                     SSCLQPTAPVIGESFSQFKQDSRYIIGELLVLYLRGGPGEPILETVFIEKIHERCLQNA
                     ECVGI"
     CDS             1480..3810
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     419.7; E-value: 4e-127)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_4"
                     /sec_met_domain="LANC_like (E-value: 3.8e-27, bitscore:
                     86.6, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="DUF4135 (E-value: 3.3e-61, bitscore:
                     199.2, seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCEVVTSSGTVYYKPRPAGNELFVSALADWMAKHTEPGLWLGLKF
                     PEVADCGDHTWVAPVHHQPLADTSEASRYYHRAGHLLGLSYLVNITDLHHENIIATATQ
                     PVPVDLETIMSVFPRSVPDQNEAGAATLRQTTQSPAATGLIPLGSCLQELGGDVSGLAA
                     DGLRVKRRVLDRQGRSDMRYVHVVSEVTPENNRPILEGTPVPPAKYVDDIVEGFATVLR
                     TAINHRESLLALLHQHANSIHVRVIARMTNDYAVVLAGLSRVSGNNNPERIMAMLRENA
                     AGLADTMVASEEAQLRRWAVPHFWAAASERIIRDPWGQPTGKLDEAPLENTLAKINSFT
                     SESIDHQVSLIRTAFRSPEQIVLPLGGGLAKPGAGSFEEFENTHFSALRAQAVTGIDGS
                     VNWPVLAIDERDQLTVQPLIGGVYRGLAGVAELLVTTRKTNPRWQLLAQHLLNTLRHES
                     HSLLEDASAVQSYYQGPASQLAAAERLRDAFELSAPWISQGYGHLLDTLGMAAHDCRLD
                     VMEGAAGMIIALRHHQDSRTRALCRELGHRLRLAAHKGWDSKDVCPLSRNASFAHDSGG
                     MGTGVLIAAAMTEEVELVESWRGAWEFENTFKLAEGWRDARSPGENISTHWCHGLAGIA
                     LARIMWLKTIRDNPFLSTVISPDEIVRIRQELDEAARLLARDLAKSGSPSLCHGISGGA
                     LVLDLAGKQLGNPQWRAHAEDLVIRAGATLSRCPWLWGDHDVRDFGIMTGPGGLLLAQR
                     MLRSPHGGVGPLLPDLGRIGAAS"
     misc_feature    2074..2076
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2140..2142
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2365..2367
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             3807..5921
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 182.3; E-value:
                     2.7e-55)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_5"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.3e-32, bitscore:
                     104.1, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVLQQSEQDCLLACYAMILSHFRVRVSPGDLRGWQPLPPDGLS
                     LGYLRRLNSEYGLAMSARKVDRERMPEDQLRRLRGPVIAHWEGRHFVVIERFGRRHVSV
                     VDPAMGRLRLHYEDFWRLFSDVLVLLTPTREFTRRSPQRDESAQPLRALIPGGAAFLLA
                     ASVILAQLVTLGVTAGTRQLFDLGPPQPSVVLLGLVLAAGLTGASFAIRSLGLQRGSDH
                     FEKRYTHRLFSGLFSQRLSYFAGQSVGALTEKLNLRFVLKNSLVMTILPSVLSVLSLLL
                     TLTYLILVSPPLATLLVVGSTAYFALTLFLTSRQMEASQTQVQAQVEMSSETQATLNNI
                     DAVKATGTEDYHQDRWTMLNRRVNDEYKRVIRWSTLTGGVQSGYTTIMLVLVVAVGLWL
                     AAAEHVAIADIVLFQTGMALFTAAVSEAQGVVQQIANVAVYQDKQADLFHAAPSFGTLE
                     PAGVPGAIEATSLAFGYPGQAMVCNGIDLQVAPGEKVAVFGPSGAGKSSLLYVLLGLND
                     FSGTLRVGDANFRDSTGVLFPKMTLVEGTVRENLLLEHDREIDDAELFQVLQDVNLYET
                     IDALPAKLSSRVQAGGRNFSTGQAQRLLLARALVRGREFLFLDEAVSSLDEDNRRHFYQ
                     HVVRGERYRGVTMIMVSHDPALVDYCDTAWVMVDRETFDVLPATGRGLPCWPQSPVEAP
                     RGAVPRRALE"
     CDS             6071..6337
                     /locus_tag="ctg3_6"
                     /transl_table=11
                     /translation="MVHCGAGPRSPSLEDKNKATAQGARIKGDREMIKRLLAMAAGTLV
                     CMSVLFTSATPARASEEPVGYDVATSATGAEPSQFCFIAGFCG"
     CDS             6385..7659
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 149.4; E-value: 2.6e-45)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_7"
                     /transl_table=11
                     /translation="MLEQIQKGWGRAEYMARVPRWLQFGLLLWGTAGLVSDINITLRTH
                     PLDSSVAWFLAEVTLSYLAAAVSLFSARVSIILVTLAMYTSFISFRPLFLLIPIAMIAL
                     VTSTLCKKTLIITHCALTAIWATLVAWRGDTIIVQQMEPGAFWWVTFWVILASCLIGLA
                     LRYLVIRTAKTQAQLREAEAQAEQIRREERQDLARELHDVVAHHITVITMQVMSRRHSQ
                     DPVELRETLGIIDDSAREALNELRALLDVLRTDEENGPRPLSSQVVTGPSLQEQVEHHV
                     DSLTRLGFQVAKASVDPRIESLPLSTKTTSTRIVQESVTNIIKHAHHDATCTISLSLQP
                     TEVEVRIVNNRVKPLERSSSTSYGLTSLRERVLAVGGSYQAGRQGEEWVVEAHLPVHQA
                     NRPSWPDAPEPHETKLPKQSEERTQ"
     CDS             7662..8663
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 191.6; E-value:
                     2.8e-58)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_8"
                     /transl_table=11
                     /translation="MLAATIQPPMATQPLTPPPVRQWAVETRGVTKRYGSQTVVDHVDL
                     AIPQGGVYGFLGPNGAGKSTTMKMLLGLAKPTSGEVRIFGRDLRANRGDILPRIGSLIE
                     GPAFYPHLTGAENLRLVADYLSCDRESVDRTLHIVGLTDAAKKKARQYSLGMKQRLGIA
                     MALISDPELLLLDEPTNGLDPAGVAEIRGLITQLAHERGITIMVSSHLLSEIEQMADVV
                     GIIQAGHLRYQGTLAGLRDQGRLVMKVSPVNTAMAHLESLGLRPETVGNEIFLPPMQDD
                     LIADAVARLVGAGVRIARVELQRKSLEEAFLELTETPVVMAEQPKRGRRSRA"
     misc_feature    7704..7706
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             8660..9430
                     /locus_tag="ctg3_9"
                     /transl_table=11
                     /translation="MSTLALEIRKHHRSRLPFLLLGLGAVEILWLGSAVATQASKAQGI
                     RTLQTAALYDYLNFLTVLLGPTIAFLATRVAGVDQDGRMGQLFRALGQSAKRQFMLKLA
                     LLTGMGFILSMAMFAVSITIGYRAGLLEAGSYDSTFWLVAALGLISTLAISAVQLALCH
                     LIDNAAGSVVIGIIGSLVASFLPFLHLPQLGWLLPWSLLVAGSPYPLITPETQSAPDFP
                     LVPNPGLMVALAGIIALAWVALSAWLVIRKEENA"
     CDS             9427..10218
                     /locus_tag="ctg3_10"
                     /transl_table=11
                     /translation="MTAATFSARPVAAQRIGLVTAWKVERAKVRRSWFLGGAVILSIFA
                     QLLGVWNYTSNLAIMQEQGLTWFGVWAQGAILVTSIFLPILYGVILAQAGALEHQTRGW
                     QRLASIDRAGTAVSGKMLVALELALTGMAVYLVTAVAAGLFLGFDPSQLGPYLARALCG
                     ALGAWAVGAVTLMLGTWLRTFAAIASAALGATMIGMGLTAAAPPLAAAYPFALITYGLG
                     ARAAGDEFASIGSMAATAFISLIWVALSAWIMRSRVRRREW"
     misc_feature    9799..9801
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             10283..10924
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 146.2; E-value:
                     1.3e-44)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_11"
                     /transl_table=11
                     /translation="MLHALRTFLDNEDGVVVVGTAEDGEAAIEQAHALKPDLVLMDLKM
                     PRMNGIDATHKITDELPGTRVVALTTFSTLDYVVPALRAGASGYLVKDAQPDEILTAIK
                     TAMDDNLPLSPGVVRLLARQVIGGAHDPEVVSGSAATEVGLAPREISVLQFLGRGLSNR
                     EIAKEMYISEGSVKAYLANACMKLGVRDRLQALIRGFELGIVSPRLSIEG"
     misc_feature    10526..10528
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(11067..12413)
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 190.5; E-value: 8.5e-58)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_12"
                     /transl_table=11
                     /translation="MNTTTPDVVNTPASDAPRPRRFSIGRLVGSSLQAVGRFLQLLVMW
                     PLEVATLLLVCVTFSSMALGVGVLLVPVAVGVLRWVATLKRRRVGTWSGSPVESPYLPL
                     SPLKPGFRGMTDRTWALLKDPSTWRDIAWLFMDYVVSAFLSILVLGFLLIGLIPLGAVL
                     LGDAAVESLKGVAFGGVGVEGASFSITFQDDPILAAIVSLLVMLPVTLVCAPRLLRVYN
                     RFARWALGPNKRTRLAARMQQLSRTRQETLESSAAELRRLERDLHDGTQGRLVAMGMTI
                     STAQALMRTDPQAAEALLSEAKDASSKALGELRDLVRGIHPPVLADRGLADAVRALATD
                     CVLPVRVSANIPARCDLAVESAAYFAVSELLTNVVKHAQASRIDVDMWVAAGELRASVT
                     DDGRGGADPGAGSGLRGIERRLAAFDGVLTVNSPAGGPTAVSFTMPLSS"
     CDS             12624..13292
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 116.6; E-value:
                     1.5e-35)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg3_13"
                     /transl_table=11
                     /translation="MRVLIAEDQFLLRDGLSRMLQALGCEIVATAQTGPELRRALLTED
                     LDVAVVDVRLPPTFTDEGLRVAIDARRQRPGLPVLVLSQYVETLYARELMEDRRGGVGY
                     LLKDRVLNTEHFFGAMQQVAAGGTCLDPEVVSRIMGKRTGQPPLDRLTPRELETLSHMA
                     EGKTNAAIAKAMFVTEKAVAKNVNSLFGKLRLTPSEDDNRRVIAVLQYLEASDPNPASR
                     "
ORIGIN
        1 caccgacggc cgagtcatcg aagtgggcca gcacgtctac cgcccgtcgc tgtactcctt
       61 ccacttctcc ctgttcacat cctgacgcag cgagggtcgc cctggggaca ccactagccg
      121 ttccctcccc tctacccatg cgcaggatgg actttcttcc cagaagcctt cctgcagacg
      181 gcacgctccc ccgcccagaa gacgtccccg tcaagccgcg cacagctgaa cgctgacaag
      241 ccctgatacc cgaatcggca cccagtggct ggaaaatctt ccaacgacac aagaaacacc
      301 gggattcctc atcgacaacg cctttgaaaa caatagccaa gaggaataat ccaccattag
      361 ccagttcacc agtcctcatt cgcccaaagg caggttaagg ctattgcatg accccagatc
      421 ggtgtttaga ttggtaacaa cttcagcgcg caggaagcac aacagaagaa gaaaagaaaa
      481 ttagatccga caacggaacc aaccaagaaa ggcaagcatc atggagaaga agtacaacga
      541 cgaaatcatc gacaacctcg ccgagatgac cgacaccgaa atcgaagaac tcctcggagc
      601 cggccgaggc gtcgtcccca ccgtcaccca cgaatgccac atgaactctt ggcagtggtt
      661 cttcggctgc tgctgaaaca ccaaggatag gccggggaat atggttattc cccggccacc
      721 tatatcctga aaacttattc agcaactcac ccgactcccc agcatcccta ggttcgcaag
      781 gagccatgta gagacaaagc cgtttgctga atgaccctcc tagaaaatat caagcattga
      841 agcttattca taggacggct gataaacagt aaaactcctt gtcaaagcag gttggctgcg
      901 gctgtgaata gccctcatta aaacactaca tcctaatcta gttatacgaa ccaccaaaag
      961 aaccaccaac cctctcgccc aaatccacct ctatgaaaca gtattcagat tctctcattg
     1021 gagaccgcca tgacgcagat gcaatcagca ccgacaatgc ctttccccat gattatcgag
     1081 caggcactcg gcgatgcact ttcgcagcat atcctaaacc tcgcgcccaa aggcgcttta
     1141 gatgcctacg cattccgcat tctggagaca cctctcgtgt atcttctcaa tgaacaccgt
     1201 ctccaggata ggttctccgg gaccacccct gaggtacaat acgaggagtt ctccgataat
     1261 gtaacgggaa tcctgtttga actgcgagaa cgattccccg atcactggcg ccgttggctg
     1321 gaggcaggaa cttccctgag agcgactttc gaaacggtcc tgcgacgtgt cacagaggat
     1381 gccaccccgc tctcccaact cttgaaagca caccatcttg acgctcgccc tcgtgtgatc
     1441 tccattaagc cattgggcga tatccacccc cagggtgtgg tgtgtgaggt ggtgacatcc
     1501 agcggcactg tttactataa accacgcccc gccggcaatg agctcttcgt ctcagccttg
     1561 gctgactgga tggcaaagca tacggaacct ggtctctggc tgggcttgaa gttccctgag
     1621 gtggctgact gtggagacca tacctgggtg gctcccgtac accaccagcc gctcgctgat
     1681 acctctgagg ccagccgcta ctaccaccgg gcaggccacc ttctggggtt gtcatatctg
     1741 gtgaacatca ccgacctgca ccacgagaac atcatcgcta cggccaccca gccggtgccg
     1801 gtggatctcg agaccatcat gagtgttttt ccccgctccg tcccagacca gaacgaagcc
     1861 ggcgctgcca cgctgcggca gaccacccag tctccggctg ccaccggcct gattcctctg
     1921 gggtcctgtc ttcaggaact cgggggcgat gtcagcggat tggctgcgga cgggctgcgg
     1981 gttaaacgcc gggtcctgga caggcagggc cgctccgata tgcgatacgt ccatgtggtc
     2041 tccgaggtca cacctgagaa caatcgccct attttagagg gcacccctgt gccaccggca
     2101 aaatacgttg acgacattgt tgagggattt gccacggtgt tacgcacggc aatcaaccat
     2161 agggagagcc tgcttgccct gctccatcag cacgcgaaca gcatccatgt gcgggtgatc
     2221 gcacgcatga ccaatgacta cgccgtcgtg ctggcgggcc tgtcgcgggt cagtggcaac
     2281 aacaacccag agcgcatcat ggccatgctg cgtgagaatg cggccggcct ggctgacacc
     2341 atggtggcct cggaagaggc ccagttacgg cgctgggcgg tccctcactt ctgggcagcg
     2401 gccagcgaga ggataattcg agacccctgg ggacagccga ctggaaagct ggatgaagcg
     2461 cccctcgaga acaccctcgc caagatcaac agtttcacct cagagagcat cgatcaccag
     2521 gtatccctga tccgtacggc gtttaggagt ccggagcaga ttgtgctccc ccttggcggt
     2581 ggcctggcga aaccaggagc tggttccttc gaggagttcg agaacacaca tttcagcgcc
     2641 ctacgcgcgc aggctgtcac tgggatagac ggcagcgtca actggccagt actcgcgatc
     2701 gatgagcgtg accagttgac ggttcagcct ctgatcggag gggtataccg cggccttgcc
     2761 ggagttgcag agctcctagt gaccacacgg aagacaaacc ccagatggca gctgttggca
     2821 caacacctgc tcaacactct cagacacgaa agtcactctc tgttggagga tgcctcagca
     2881 gtccagagtt actaccaagg tcctgcaagt caacttgccg cagccgaacg tctcagggac
     2941 gccttcgagc tgagtgcgcc ctggattagc cagggttatg ggcatctcct cgataccctg
     3001 gggatggccg cccacgactg tcgcctagac gtgatggaag gtgcggccgg gatgatcatc
     3061 gcgctacgcc accaccagga ttcccgaacc cgcgctctgt gcagagagct gggacaccgg
     3121 ctacggctcg ccgcccacaa gggctgggac tccaaggatg tgtgtccgct ctcccgcaat
     3181 gctagcttcg cccatgactc gggcggcatg ggcactggcg tgctgatcgc cgccgccatg
     3241 accgaagagg tggagttggt tgagtcctgg cgcggtgcct gggaattcga gaacaccttc
     3301 aagctggccg aggggtggcg ggatgcccgc tcccccggcg agaacatctc cacccactgg
     3361 tgccatgggc tggccggcat cgctctggct cgcatcatgt ggctgaagac catccgagac
     3421 aatccgttcc tgagcaccgt gataagccca gacgaaattg tccgcatccg ccaagagctg
     3481 gatgaagccg cgaggctctt ggcccgggac ctcgcgaaat ccggctcccc gagcctctgc
     3541 cacgggatct ccggaggcgc gctggtgctc gacctggctg gcaaacagct cggcaacccc
     3601 cagtggcggg cccatgccga ggacctcgtg atccgcgccg gggcgactct ctcgcgttgc
     3661 ccatggctgt ggggggacca cgatgtccgg gacttcggca tcatgactgg gcctggcggg
     3721 ctgctcctcg cccagcgcat gctgcgcagt cctcacgggg gcgtgggccc cctcctaccg
     3781 gatctcggac gcataggagc ggcatcatga aagtcgtgct ccagcagagt gagcaggact
     3841 gcctgcttgc ctgctatgcc atgatcctca gtcacttcag ggttcgggtc tccccgggcg
     3901 acctgcgcgg ctggcagccg cttcccccag acggcctgag cctcgggtat ttgcgcaggc
     3961 tgaactccga gtatgggctg gcgatgagcg cccgtaaggt cgaccgggag cgtatgcccg
     4021 aggatcagct acgtcgtctc cgaggccccg tgatcgccca ttgggagggg cgtcacttcg
     4081 tggtcattga acgattcggc cgacggcacg tgagcgtggt cgatcccgca atggggaggc
     4141 tgaggctcca ctatgaagac ttctggaggc tgttcagcga cgtcctggtt cttctgacac
     4201 ccaccaggga gttcacccgg cgatccccac aacgcgacga gagcgcccaa cctctgcggg
     4261 cgctgatccc tggaggagct gcattccttc tggcggccag cgtcatcttg gcgcagctgg
     4321 tgactctcgg cgtcaccgca gggacgcgtc agctctttga cctcggcccc ccgcaaccct
     4381 cggtggtatt gctcggcctc gtgctggcag cgggactgac aggagcctct ttcgcgatcc
     4441 gttctctggg gcttcagcgc ggctccgacc atttcgagaa gcgctacacc caccgtctct
     4501 tctcggggtt gttctcccag cgcctgtcct atttcgccgg acagtcagtc ggagccctca
     4561 ccgagaagct gaatctcagg ttcgtcctga agaactctct cgtcatgacg atcctgccat
     4621 cagtactgtc ggtgctctca ctgctgctca ccctgaccta cctcatcctg gtctcaccac
     4681 cgcttgcgac cctgctggtc gttggctcga cggcctattt cgccctgacg ctgttcctga
     4741 ccagcaggca gatggaggcg agccagaccc aggtccaggc acaggtggag atgagcagtg
     4801 agacccaggc caccctcaac aacatcgatg cggtcaaggc cacgggaacg gaggactatc
     4861 accaggatcg ctggacaatg ctgaaccgga gggtgaacga cgaatacaag cgagtcatcc
     4921 gatggagcac gctgacgggg ggcgtccaat cgggctacac caccatcatg ctggtgctcg
     4981 tggtcgcagt cggactgtgg ctggcagcag cagagcacgt ggccatcgcc gacatcgtcc
     5041 tgttccagac cgggatggcc ctgttcacgg ctgctgtctc cgaggcgcag ggagtggtgc
     5101 agcagatcgc caacgtcgcg gtctaccagg acaagcaggc cgatctattc cacgccgccc
     5161 cgagcttcgg aacgctggag ccggccggtg tgccaggcgc gatcgaggcc acctcactgg
     5221 cgttcggtta ccccgggcag gcgatggtgt gcaatggcat cgatctccag gtcgcccctg
     5281 gggagaaggt ggccgtgttc ggtccttccg gggccgggaa atccagcctc ctgtatgtcc
     5341 tgctggggtt gaacgacttt tcgggaactc tgagggtcgg agacgccaat ttccgcgaca
     5401 gcaccggggt gctgttcccc aagatgaccc tggtagaggg aacggtgcgg gagaacttgc
     5461 ttcttgagca cgaccgggag atcgacgacg cagaactgtt ccaagtgctc caggatgtca
     5521 atctctacga gaccatcgac gccctgccgg cgaagctctc ctcgcgtgtc caggctggcg
     5581 gccgcaactt ctccaccggt caggcccagc ggctcctgct ggcccgggcg ctggtgcggg
     5641 gacgcgaatt cctgttcctg gacgaggccg tcagcagcct ggacgaggac aaccggcgtc
     5701 acttctacca gcatgtggtc cggggcgagc ggtaccgggg ggtcacgatg atcatggtca
     5761 gccacgaccc agctctggtg gactactgcg acacggcgtg ggtcatggtc gatcgagaga
     5821 cctttgacgt gctgcccgcg acaggccggg gtcttccctg ctggccgcag tcgccagtcg
     5881 aggcccccag aggagccgta ccacggcgcg cgctggagta gccagcaaaa gccgtagtga
     5941 acaccgctta ggcccagtgg gattccgtcc actgggcctt tgactgcacc cggttgcttg
     6001 cccattcatc acggaaggcg aggcgggacc tgcttctggc gacagctaaa agacgcccgg
     6061 aagctagtca atggtccact gtggcgcagg gcctcgctct cctagccttg aggacaagaa
     6121 caaagcaacc gcccaagggg cgagaatcaa aggagatcga gagatgatca agcgcctact
     6181 ggccatggcc gccggaaccc tggtgtgtat gtccgtcctg ttcacaagcg ccaccccggc
     6241 gagggcgtcc gaagagcccg tcggctacga cgtcgcaaca tcggccaccg gggcggagcc
     6301 tagccagttc tgcttcatcg ctgggttctg cggctgatac ccgaaccacg aagccacata
     6361 cacactcatc gagaggaatg agacatgctt gagcagattc agaaaggctg gggcagggcc
     6421 gagtacatgg cccgggttcc ccggtggctc cagttcggtc tgctcctctg gggaacagcg
     6481 ggattggtga gcgatatcaa catcaccctt cgaactcatc ctctcgattc gtcagtggcc
     6541 tggttcctag ccgaggtgac cctcagctat ctagcggctg cggtctcgct cttctcagct
     6601 cgcgtctcaa tcattctggt cactctggcc atgtacacca gcttcatcag ctttcgtccc
     6661 ctcttccttc ttatcccgat cgcgatgatc gccctggtaa caagcaccct gtgcaaaaaa
     6721 actctcatta tcacccactg cgccctgacc gccatctggg ccaccctcgt cgcctggcgc
     6781 ggggacacaa taattgttca gcagatggaa ccaggagcgt tctggtgggt gaccttctgg
     6841 gtcatcctgg ccagctgcct cattggtctg gccctgcgat acttggtgat ccggactgcg
     6901 aagacgcagg cccaactacg ggaggccgag gcccaggcgg agcagattcg ccgtgaggag
     6961 cgccaagacc ttgcccggga gctccatgac gtggtggctc accacatcac cgtcatcacg
     7021 atgcaggtaa tgtcccggcg ccactcccag gacccggtcg agctgcgcga gaccctcggc
     7081 atcatcgacg attcggcacg tgaggctctg aatgagttga gggcgctcct ggacgtgctg
     7141 cggaccgatg aggagaatgg tccccgcccg ctgtcgagcc aggtcgtcac cggcccgagt
     7201 ctccaagagc aggtggaaca ccacgtcgat tctcttacca gactggggtt ccaggtggcg
     7261 aaggcatcgg tagatccgcg catcgagtcg ctgcccctct cgacgaagac caccagcacc
     7321 cgcattgtgc aggagtcggt gaccaacatc atcaagcatg cccaccacga cgccacctgc
     7381 accatttccc tgtcgctcca gccgaccgag gtggaggtca ggatcgtcaa caaccgcgtc
     7441 aagcccctcg aacgttcatc ttccaccagt tatggcctca cctcactgcg agagagggtc
     7501 ttggcggtcg gcggcagcta ccaggccggg agacagggtg aggaatgggt cgtcgaggca
     7561 caccttccgg ttcaccaggc caaccggcct tcctggcccg atgcgcccga accacacgaa
     7621 accaaacttc ccaagcagtc agaagaaagg acacagtgaa catgcttgca gcaaccattc
     7681 agcctcccat ggccacccag cctttaacac ccccgccagt cagacagtgg gccgtggaaa
     7741 cccgcggtgt tacgaagcga tacgggagcc agacggtcgt cgaccacgtc gacctggcca
     7801 ttccacaggg cggggtctac gggttcctcg gccccaacgg ggcagggaag tccacgacca
     7861 tgaagatgct gctcgggctg gcgaagccga ccagcggcga ggtccgcatc ttcggccgcg
     7921 acctccgcgc gaaccggggc gacatccttc cccggatcgg ctccctgatc gaggggccgg
     7981 cgttctatcc gcacctgacg ggagccgaga acctacgcct ggtagccgac tacctgtcct
     8041 gcgaccgtga gtccgtcgat aggactctcc acatcgtcgg actcacggac gcagccaaga
     8101 agaaagcccg ccagtactcc ctggggatga agcagcgtct ggggatcgcg atggctctga
     8161 tctccgaccc cgagctgctg ctgctcgacg agccgaccaa cggtctggac ccggcgggcg
     8221 tggcggagat ccgtggcctg atcacacagc tcgcccacga gcgcggcatc acgatcatgg
     8281 tctcctcaca tctgctgtca gagatcgagc agatggccga tgttgtcggc atcatccagg
     8341 cgggccatct ccggtaccag ggcacgctag ccggtctcag ggatcaagga cgcctcgtga
     8401 tgaaggtctc gccggtgaat acggcgatgg ctcacttgga aagcctgggt ctgcgccctg
     8461 aaacagtggg caacgaaatc ttcctcccac ccatgcagga cgatctcatt gccgatgcgg
     8521 tcgcccggct cgtcggagcc ggtgtgcgca tcgcccgggt cgagttgcag cgcaagagcc
     8581 ttgaggaggc cttcctggaa ctgaccgaga ccccggtggt gatggccgag caaccaaagc
     8641 gaggcaggag gtcccgagca tgagcaccct cgcactggag attcgaaagc atcatcgtag
     8701 tcggctgccc ttcctgctat tggggctggg ggctgtggaa atactgtggc tggggagtgc
     8761 cgtagcaacc caagcctcca aggcacaagg gatccgtacc cttcagactg ctgcgctgta
     8821 tgactacctg aatttcctga ccgtgctgct cggccccacc atagcgttct tggccacacg
     8881 ggtggcgggg gtcgaccagg atggccgcat gggccagctc ttccgggccc tggggcagtc
     8941 agccaaacgc caattcatgc tgaaactcgc actcttgaca gggatggggt tcatcctcag
     9001 catggcgatg ttcgcagtca gcatcacgat tgggtacaga gctggtctat tggaggcggg
     9061 ttcgtacgat tccaccttct ggctggtcgc ggccctgggc ctcatcagca cacttgcgat
     9121 cagcgcggtc cagctggcgc tgtgtcatct gatcgacaat gcagctggca gcgtggtcat
     9181 aggtatcatc ggttccctgg tcgcctcatt tctgcctttc ctgcacctcc ctcagctcgg
     9241 ttggctgctg ccctggagct tgctggtggc aggaagcccc tacccattga tcacccctga
     9301 gacgcaatcc gctcccgact ttcccctagt tcccaacccc ggcctcatgg tcgccctcgc
     9361 cggcatcatc gccctagcgt gggttgctct gtcggcctgg ctcgtcatcc gcaaggagga
     9421 gaacgcatga ccgccgcaac attctcagca aggccagtgg cggcgcaacg catcgggctt
     9481 gtgaccgcct ggaaggtcga gcgcgccaag gtaagacgct cctggttcct gggaggagcc
     9541 gtgatcctca gcatcttcgc ccagctgctg ggagtctgga actacaccag caacctggcc
     9601 atcatgcagg agcagggact cacctggttt ggcgtctggg cacagggcgc catcctcgtc
     9661 accagcatct tcctgcccat cctctacggc gtcatcctgg cccaagctgg agcccttgag
     9721 caccagaccc ggggctggca gcggctggcc tcaatagacc gcgccggcac tgccgtctca
     9781 ggcaagatgc tcgttgcctt agagctggca ctgacaggga tggccgtcta tctggtgacc
     9841 gcggtggcag cggggctgtt cctgggattc gaccccagcc agcttggccc ctacctagca
     9901 cgtgcattgt gcggcgctct cggggcttgg gcggtgggcg cggtaaccct catgctcggc
     9961 acctggctcc gtaccttcgc cgccatcgca tcagcggctc tgggagccac gatgataggc
    10021 atgggactga ctgccgcggc accacccctg gcggcagcct atcccttcgc cctgatcacc
    10081 tatgggctgg gggcgcgagc tgcgggagac gagttcgcct ccatcggcag catggcagcc
    10141 accgctttca tctcgctcat ctgggtggca ctgagcgcct ggatcatgag atcccgggtt
    10201 cgccgccgtg aatggtgatg aggaggtaat atcccgttac atgacagaca tcaccgtcct
    10261 cgttgtcgat gatcagccgc tcatgctcca cgctctgcgg acgttcctcg acaacgagga
    10321 cggtgttgtc gtggtaggaa ccgccgagga cggggaggcc gcgatcgagc aggcacacgc
    10381 cctcaaaccg gacctcgtgc tgatggacct gaagatgccg cgaatgaacg gcatcgacgc
    10441 aacccacaag atcaccgacg aactgcccgg cacccgggtg gtcgcgctca ccaccttctc
    10501 caccctcgac tacgtcgtcc cggctttacg cgctggggcc tccgggtatc tggtcaagga
    10561 tgcccagccg gacgagatcc tcaccgcgat caagacggcg atggacgaca acctgccgct
    10621 gtcccccggc gtcgtacgcc ttctggcccg gcaggtgatc ggcggcgccc acgacccgga
    10681 ggtcgtctcc gggtcggccg cgacggaggt gggcctggct ccccgcgaga tctccgtcct
    10741 gcaattcctg ggacggggac tcagcaaccg tgagatcgcc aaggagatgt acatctccga
    10801 gggctccgtc aaggcctacc tggccaacgc ctgtatgaaa ctcggcgttc gcgaccggct
    10861 ccaagccctg atccgcggat tcgagctggg catcgtcagt ccccggctct ccatcgaggg
    10921 ctgagcaaca gcgcactgga tcgcgcgccg acgcgcgatc cgcaggccag catgacgcct
    10981 ggacgggcac cagctccgcc ggccacggcc ggcggagtct cttggccggt gttgtcccgg
    11041 ctgtgccagc gatacggacc ctgccgtcag gagctgagcg gcatggtgaa gctgacggcc
    11101 gtcgggccgc cggccgggct gttgaccgtg aggacgccgt cgaacgccgc cagccggcgt
    11161 tcgatcccgc gcagcccgct gcctgcgcca ggatcggccc cgccgcgacc atcgtcggtc
    11221 acgctggccc gcagctcccc cgccgcgacc cacatatcga cgtcaatccg gctggcctgc
    11281 gcgtgcttga ccacattggt cagcagctcg gagaccgcga aataggccgc cgactcgacc
    11341 gcaaggtcgc atcgtgcggg aatgttggcg ctcaccctga ccggcagcac gcagtccgtc
    11401 gccagggccc ggacggcgtc ggccagtcca cggtcggcca gcaccggcgg atggatgccg
    11461 cgcacgaggt cccgcagctc gcccagcgcc ttgctggagg cgtccttggc ctcggacagc
    11521 aacgcctccg cggcctgcgg gtcggtgcgc atcagtgcct gggcggtgct gatggtcatg
    11581 cccatcgcga ccaggcggcc ctgggtaccg tcgtggaggt cgcgttcgag acgccgcagc
    11641 tcagcggccg acgattcgag ggtctcctgc cgggtgcggg acagctgctg catccgggcg
    11701 gcgagccggg tgcgtttatt cggccctagc gcccaccggg caaaccggtt gtacaccctc
    11761 agcagcctgg gtgcacagac cagcgtgacg ggcagcatca ccagcagact gacgatggcc
    11821 gcaaggatcg ggtcgtcctg gaaggtgatg ctgaaggatg cgccctcgac acccacacca
    11881 ccaaaagcca cgcccttcaa actctccaca gcagcatctc ccagaagaac cgcacccaag
    11941 gggatgaggc cgatcagcaa gaaacccagg acgaggatgc tgagaaaggc gctgaccacg
    12001 taatccatga acagccaggc gatgtcacgc caggtgctgg ggtccttgag cagagcccac
    12061 gtcctgtcgg tcatgcccct gaagcctggt ttcagcggcg ataggggcag gtagggcgac
    12121 tcgaccgggc tccccgacca cgtgccgacg cgacgccgct tcaaggtggc cacccagcgc
    12181 agcacgccca ccgccaccgg caccagcagg accccgaccc caagggccat ggaggagaat
    12241 gtgacgcaca ccagcagcag cgtggcaacc tccagcggcc acatcaccag cagctgcagg
    12301 aaacgaccga cagcctgcag gctggagccg actagccgtc cgatcgagaa tcgtcgggga
    12361 cgcggggcat cagacgccgg ggtgttcacg acgtcggggg ttgtggtgtt catcttgtct
    12421 cctcacattt tctgtgcctc ccatcctgct gagacgatag cgggaacaca gtggtgaaaa
    12481 gaccactttt tccgcgccag ggtgcaatgg cgcaccgggg acggcgacga gctggcagac
    12541 tcagcgctgg ggaagcagag accagtgagg cagagaccgg tgggaaaacg agaaaccggc
    12601 ggagatgcga gagaggtgga accatgcgcg tgctgattgc cgaggaccag ttcctgctgc
    12661 gcgatggcct gagccgcatg ctgcaggccc tgggatgcga gatcgtggcg acggcgcaga
    12721 ccggacccga gctgcgtcgg gcgttgctga ccgaggacct cgacgtcgcc gtcgtcgacg
    12781 tgcgcctgcc accgacgttc accgacgagg gactgcgcgt ggcgattgat gcgcggcggc
    12841 agcgtccggg cctaccggtg ctggtgctct cgcagtacgt cgagaccctc tacgcccgcg
    12901 agctcatgga ggaccggcgc ggcggggtcg ggtacctgct gaaggaccgc gtgctcaaca
    12961 ccgagcactt cttcggcgcc atgcagcagg tggcggctgg gggcacctgc ctcgacccgg
    13021 aggtcgtctc ccggatcatg gggaagcgca cgggccagcc gccgctcgac cggctcaccc
    13081 cgcgggagct ggagacgctg tcccacatgg ccgagggcaa gacgaacgcc gcgatcgcca
    13141 aggcgatgtt cgtcacggag aaggccgtcg ccaagaacgt caacagcctg ttcgggaagc
    13201 tccgcctgac tccctccgag gacgataacc ggcgcgtcat cgccgtcctg cagtacctgg
    13261 aggcctccga ccccaacccc gcgtcccgct gacttccagc cggccgacta tttgttatta
    13321 caagcgcttg acttgacctt gccattgggg ttgacttggt ccgacgacgg cgatgacgct
    13381 gccgcaagac gacgaaggag cccgaagtct atgactgaca tcgaatacac acccggaccg
    13441 ctcctggacg ccgcccggaa taccccgacg gcgctctgga acgactcgtc cgacctggac
    13501 gaactgcgcc agtccatctc ctacggcggc gtcggagcca cctgcaaccc ggtgatcgcc
    13561 tacaccacca tcaagaagca cctcgacgtg tgggcccccc gcatccaggc catcgccgac
    13621 acccacccga cgtggggtga gtcggagatc ggctggcagg ccgtcaagga catgtcccag
    13681 gaggccgcga agctcctcga acccgtcttc gacgagcaca agggccgcaa cggccgcctg
    13741 tcggtgcaga ccgacccccg cttccaccgc gacgcgaaga agctcgccga ccaggccgag
    13801 gagttccaca
//
