LOCUS       c00450_3300009..        7470 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300009709.a:Ga0116227_10023491.
ACCESSION   c00450_3300009..
VERSION     c00450_3300009..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 08:49:43
            Original ID  :: 3300009709.a:Ga0116227_10023491
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7470
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7470
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[923:6950](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      924..6950
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..7470
                     /SMILES="NC([*])C(=O)NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7470
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             924..6950
                     /NRPS_PKS="Domain: AMP-binding (28-428). E-value: 8.3e-84.
                     Score: 273.2. Matches aSDomain:
                     nrpspksdomains_ctg450_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (543-607). E-value: 3.4e-24. Score:
                     76.6. Matches aSDomain: nrpspksdomains_ctg450_1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (668-968). E-value:
                     1.7e-122. Score: 399.8. Matches aSDomain:
                     nrpspksdomains_ctg450_1_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1133-1553). E-value:
                     2.8e-103. Score: 337.4. Matches aSDomain:
                     nrpspksdomains_ctg450_1_AMP-binding.2"
                     /NRPS_PKS="Domain: PCP (1662-1738). E-value: 7.1e-23.
                     Score: 72.4. Matches aSDomain:
                     nrpspksdomains_ctg450_1_PCP.2"
                     /NRPS_PKS="Domain: Thioesterase (1782-1985). E-value:
                     1.3e-27. Score: 89.5. Matches aSDomain:
                     nrpspksdomains_ctg450_1_Thioesterase.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     467; E-value: 1.2e-141)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg450_1"
                     /sec_met_domain="Condensation (E-value: 5.3e-87, bitscore:
                     278.7, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 5.4e-117, bitscore:
                     377.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.3e-18, bitscore:
                     52.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNNFYQKFSEISAARSYFKSLCIADLLKQQSKKNPDAIAILTPG
                     RAPLTYSRLWSHIQDVIAKLNSFGIGRNDRVAVALPNGAEMATAFLSIAATATCAPLNI
                     AYRTNEFEFYLKDLNAKALIVQSNIETHAIAAAKSLSIPLIKLLPVLESEAGIFVLNGC
                     ESASRVTNYPADDDIALVLHTSGTTSRPKIVPLSYRHLCTSANNICTTLQLVEGDRSLN
                     VMPLFHIHGLIGVLLSSLTAGASVVCTPGFLAPSFFNWFSEFHPTWYSAVPTMHQAILA
                     RSEVGREIIAKYPIRLIRSSSSSLPPQVMADLEKVFNAPVIESYGMTEAAHQMASNPLP
                     PLLRKPGSVGVAAGPELAIMDESGNLLQTEEVGEIVIRGANVTSGYENNPTANANAFTN
                     GWFRTGDIGYLDSDNYLFIQGRIKEIINRGGEKISPREVDEVILNHPAIAQVVTFAIPH
                     PQLGEDVAVAVVLHQNLSVTAREVQEFAALQLADFKVPAKVVFLDEIPKGPTGKLQRIG
                     LAERLGIIVSLTTETKTVFSSPITPVEKQLADIWAEVLGVEQIGIDNNFFHLGGDSILA
                     GLILNRIRKVLQVELSFLALFETPTIAGLAKNFPIQKESDSESIQSISVEIPIRAVFES
                     PTVAQLDKTITQLRTTEHGLTLPPIQPIRGDTELLPLSWAQQRLWFLNQLEGSSATYNM
                     PFSLRITGNLDLKTLQQALSEIIRRHSVLRTSFPTVNGTPRQVIHPEATMNINVVDLQQ
                     LSVTERETVLHQQAQLEAITPFNLENAPLIRCSLLELSATEYVLLLTMHHIVSDGWSMG
                     VLIRELSALYPAFCAGVPSELPELPIQYADFAVWQRQCLSGEVLETQLNYWVSQLQGVP
                     LLLQLPTDRPRARVQTHQGRTQSFSLNRDLTQKLQSLSRASGTTLFMTLLAAFATLLYR
                     YSGESDIVIGSPIANRNRSEIELLIGFFVNTLVLRTRFEANPSFEKLLLQVRETTLQAY
                     EHQDVPFEQVVEALQPQRSLSHSPLFQVMFVLQNAPIGEIELPGVTLTQLNRESTFAKF
                     DLTLSISETNHGLVGSWQYNTDLFNESTIERMAGHFQNLLSAIVENPQQVVGEIPLLSE
                     AERHQLLVEWNETKSEYPTDKYIHQLFEEQVERTPLSVAVVFEHQQLTYLELNQRANQL
                     AHHLQSLGVGPEVLVGICVERSVEMVVGLLGILKAGGAYVPLDPNYPTERLSYMLADSG
                     VKVLLTQQQLLSSLPLHTAQVVFLDTDWGLIEQYSHQNLDAEIGADNLVYVIYTSGSTG
                     QPKGVLVAHQGLLNLVFWHQAAFGITPSDIATQLAGTAFDASAWELWPYLSIGASIHLL
                     KIETIVQPQVLQNWLISQKITITFIPTPLLESLLLLEWPPSIALRIVLTGGDKLHQYSS
                     TSLPFRVINNYGPTENTVVTTSGLIVSTEQTNLLPPIGRPISNTQIYILDQRLQPVPIG
                     VTGEMYIGGDGLARGYLNLPDLTKQKFIPNPFLGSREWGVRSYELENNNQQPTPNNQHY
                     CSVYLYKTGDLACYLPDGNIEFLGRLDHQVKIRGFRIEPGEIEAVLAQHPGVQETVVIT
                     HEYSPGDKHLVAYIVPQVEVSATTEDLRHFLKQKLPNYMIPSVFVLLSTLPLTPNGKVD
                     RSALLVPDQPNSEGKLFVAPQTLTEEMLARIWAEILNIESFTRGQSNINIYDNFFDLGG
                     HSLVATLLITRIRQVFQVDLPLWRLFDAPTIAGLASSIETERQTNILKHQIEPKPWSSL
                     VPIQLGGSKRPFFLVSGGNGSEFNLINYAKLVYFLGQDQPVYGLKTRGCDPKQQPHTQV
                     EVMASDYIKEIRTLQPSGPYLLGGECIGGVVAFEMARQLVAVGQKVGLLILIDTQYPSH
                     VHQIRYFLKRVTVKIQKLKRIPYHLTKLLQLNSRELQLYTFDKVQTAKEVFVEQNYATV
                     LMRYKPRPYIGRMTLLVNEDYYQKNPAIGWDHVAAGGLEIHQVPGDHDSYLGKYVKTTS
                     DVLKGCLDAAQREFEG"
     aSDomain        1008..2207
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg450_1_AMP-binding.1"
                     /evalue="8.30E-84"
                     /label="ctg450_1_AMP-binding.1"
                     /locus_tag="ctg450_1"
                     /protein_end="428"
                     /protein_start="28"
                     /score="273.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="KQQSKKNPDAIAILTPGRAPLTYSRLWSHIQDVIAKLNSFGIGRN
                     DRVAVALPNGAEMATAFLSIAATATCAPLNIAYRTNEFEFYLKDLNAKALIVQSNIETH
                     AIAAAKSLSIPLIKLLPVLESEAGIFVLNGCESASRVTNYPADDDIALVLHTSGTTSRP
                     KIVPLSYRHLCTSANNICTTLQLVEGDRSLNVMPLFHIHGLIGVLLSSLTAGASVVCTP
                     GFLAPSFFNWFSEFHPTWYSAVPTMHQAILARSEVGREIIAKYPIRLIRSSSSSLPPQV
                     MADLEKVFNAPVIESYGMTEAAHQMASNPLPPLLRKPGSVGVAAGPELAIMDESGNLLQ
                     TEEVGEIVIRGANVTSGYENNPTANANAFTNGWFRTGDIGYLDSDNYLFIQGRIKEIIN
                     RG"
     aSModule        1008..2744
                     /complete
                     /domains="nrpspksdomains_ctg450_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg450_1_PCP.1"
                     /locus_tags="ctg450_1"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1458..1514
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0001"
                     /evalue="1.20E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg450_1"
                     /protein_end="197"
                     /protein_start="178"
                     /score="12.0"
                     /tool="antismash"
                     /translation="ALVLHTSGTTSRPKIVPLSY"
     CDS_motif       1893..1919
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0002"
                     /evalue="4.30E+00"
                     /label="NRPS-A_a5"
                     /locus_tag="ctg450_1"
                     /protein_end="332"
                     /protein_start="323"
                     /score="1.3"
                     /tool="antismash"
                     /translation="SYGMTEAAHQ"
     CDS_motif       2037..2114
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0003"
                     /evalue="1.10E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg450_1"
                     /protein_end="397"
                     /protein_start="371"
                     /score="17.8"
                     /tool="antismash"
                     /translation="VGEIVIRGANVTSGYENNPTANANAFT"
     CDS_motif       2178..2237
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0004"
                     /evalue="1.70E+01"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg450_1"
                     /protein_end="438"
                     /protein_start="418"
                     /score="-1.2"
                     /tool="antismash"
                     /translation="QGRIKEIINRGGEKISPREVD"
     aSDomain        2553..2744
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg450_1_PCP.1"
                     /evalue="3.40E-24"
                     /label="ctg450_1_PCP.1"
                     /locus_tag="ctg450_1"
                     /protein_end="607"
                     /protein_start="543"
                     /score="76.6"
                     /tool="antismash"
                     /translation="EKQLADIWAEVLGVEQIGIDNNFFHLGGDSILAGLILNRIRKVLQ
                     VELSFLALFETPTIAGLAKN"
     aSDomain        2928..3827
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg450_1_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.70E-122"
                     /label="ctg450_1_Condensation_LCL.1"
                     /locus_tag="ctg450_1"
                     /protein_end="968"
                     /protein_start="668"
                     /score="399.8"
                     /tool="antismash"
                     /translation="LLPLSWAQQRLWFLNQLEGSSATYNMPFSLRITGNLDLKTLQQAL
                     SEIIRRHSVLRTSFPTVNGTPRQVIHPEATMNINVVDLQQLSVTERETVLHQQAQLEAI
                     TPFNLENAPLIRCSLLELSATEYVLLLTMHHIVSDGWSMGVLIRELSALYPAFCAGVPS
                     ELPELPIQYADFAVWQRQCLSGEVLETQLNYWVSQLQGVPLLLQLPTDRPRARVQTHQG
                     RTQSFSLNRDLTQKLQSLSRASGTTLFMTLLAAFATLLYRYSGESDIVIGSPIANRNRS
                     EIELLIGFFVNTLVLRTRFE"
     aSModule        2928..6878
                     /complete
                     /domains="nrpspksdomains_ctg450_1_Condensation_LCL.1"
                     /domains="nrpspksdomains_ctg450_1_AMP-binding.2"
                     /domains="nrpspksdomains_ctg450_1_PCP.2"
                     /domains="nrpspksdomains_ctg450_1_Thioesterase.1"
                     /final_module
                     /locus_tags="ctg450_1"
                     /monomer_pairings="leu -> leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2991..3107
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0005"
                     /evalue="5.20E-18"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg450_1"
                     /protein_end="728"
                     /protein_start="689"
                     /score="57.4"
                     /tool="antismash"
                     /translation="ATYNMPFSLRITGNLDLKTLQQALSEIIRRHSVLRTSFPT"
     CDS_motif       3324..3389
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0006"
                     /evalue="1.40E-13"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg450_1"
                     /protein_end="822"
                     /protein_start="800"
                     /score="43.1"
                     /tool="antismash"
                     /translation="MHHIVSDGWSMGVLIRELSALYP"
     CDS_motif       3438..3476
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0007"
                     /evalue="3.40E-06"
                     /label="C4_LCL_164-176"
                     /locus_tag="ctg450_1"
                     /protein_end="851"
                     /protein_start="838"
                     /score="19.5"
                     /tool="antismash"
                     /translation="QYADFAVWQRQCLS"
     CDS_motif       3729..3818
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0008"
                     /evalue="4.90E-17"
                     /label="C5_LCL_267-296"
                     /locus_tag="ctg450_1"
                     /protein_end="965"
                     /protein_start="935"
                     /score="54.2"
                     /tool="antismash"
                     /translation="DIVIGSPIANRNRSEIELLIGFFVNTLVLRT"
     CDS_motif       3867..3986
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0009"
                     /evalue="5.00E-27"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg450_1"
                     /protein_end="1021"
                     /protein_start="981"
                     /score="86.5"
                     /tool="antismash"
                     /translation="RETTLQAYEHQDVPFEQVVEALQPQRSLSHSPLFQVMFVLQ"
     aSDomain        4323..5582
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg450_1_AMP-binding.2"
                     /evalue="2.80E-103"
                     /label="ctg450_1_AMP-binding.2"
                     /locus_tag="ctg450_1"
                     /protein_end="1553"
                     /protein_start="1133"
                     /score="337.4"
                     /specificity="consensus: leu"
                     /tool="antismash"
                     /translation="FEEQVERTPLSVAVVFEHQQLTYLELNQRANQLAHHLQSLGVGPE
                     VLVGICVERSVEMVVGLLGILKAGGAYVPLDPNYPTERLSYMLADSGVKVLLTQQQLLS
                     SLPLHTAQVVFLDTDWGLIEQYSHQNLDAEIGADNLVYVIYTSGSTGQPKGVLVAHQGL
                     LNLVFWHQAAFGITPSDIATQLAGTAFDASAWELWPYLSIGASIHLLKIETIVQPQVLQ
                     NWLISQKITITFIPTPLLESLLLLEWPPSIALRIVLTGGDKLHQYSSTSLPFRVINNYG
                     PTENTVVTTSGLIVSTEQTNLLPPIGRPISNTQIYILDQRLQPVPIGVTGEMYIGGDGL
                     ARGYLNLPDLTKQKFIPNPFLGSREWGVRSYELENNNQQPTPNNQHYCSVYLYKTGDLA
                     CYLPDGNIEFLGRLDHQVKIRG"
     CDS_motif       4509..4550
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0010"
                     /evalue="6.30E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg450_1"
                     /protein_end="1209"
                     /protein_start="1195"
                     /score="19.2"
                     /tool="antismash"
                     /translation="LGILKAGGAYVPLDP"
     CDS_motif       4746..4802
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0011"
                     /evalue="2.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg450_1"
                     /protein_end="1293"
                     /protein_start="1274"
                     /score="29.2"
                     /tool="antismash"
                     /translation="YVIYTSGSTGQPKGVLVAHQ"
     CDS_motif       5157..5189
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0012"
                     /evalue="6.50E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="ctg450_1"
                     /protein_end="1422"
                     /protein_start="1411"
                     /score="9.3"
                     /tool="antismash"
                     /translation="NYGPTENTVVTT"
     CDS_motif       5298..5387
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0013"
                     /evalue="3.70E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg450_1"
                     /protein_end="1488"
                     /protein_start="1458"
                     /score="51.2"
                     /tool="antismash"
                     /translation="PIGVTGEMYIGGDGLARGYLNLPDLTKQKFI"
     CDS_motif       5547..5612
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0014"
                     /evalue="1.90E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg450_1"
                     /protein_end="1563"
                     /protein_start="1541"
                     /score="39.0"
                     /tool="antismash"
                     /translation="FLGRLDHQVKIRGFRIEPGEIEA"
     aSDomain        5910..6137
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg450_1_PCP.2"
                     /evalue="7.10E-23"
                     /label="ctg450_1_PCP.2"
                     /locus_tag="ctg450_1"
                     /protein_end="1738"
                     /protein_start="1662"
                     /score="72.4"
                     /tool="antismash"
                     /translation="EEMLARIWAEILNIESFTRGQSNINIYDNFFDLGGHSLVATLLIT
                     RIRQVFQVDLPLWRLFDAPTIAGLASSIETER"
     aSDomain        6270..6878
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg450_1_Thioesterase.1"
                     /evalue="1.30E-27"
                     /label="ctg450_1_Thioesterase.1"
                     /locus_tag="ctg450_1"
                     /protein_end="1985"
                     /protein_start="1782"
                     /score="89.5"
                     /tool="antismash"
                     /translation="NYAKLVYFLGQDQPVYGLKTRGCDPKQQPHTQVEVMASDYIKEIR
                     TLQPSGPYLLGGECIGGVVAFEMARQLVAVGQKVGLLILIDTQYPSHVHQIRYFLKRVT
                     VKIQKLKRIPYHLTKLLQLNSRELQLYTFDKVQTAKEVFVEQNYATVLMRYKPRPYIGR
                     MTLLVNEDYYQKNPAIGWDHVAAGGLEIHQVPGDHDSYLGK"
     CDS_motif       6411..6485
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg450_1_0015"
                     /evalue="3.90E-11"
                     /label="NRPS-te1"
                     /locus_tag="ctg450_1"
                     /protein_end="1854"
                     /protein_start="1829"
                     /score="35.3"
                     /tool="antismash"
                     /translation="QPSGPYLLGGECIGGVVAFEMARQLV"
     CDS             complement(7265..7468)
                     /locus_tag="ctg450_2"
                     /transl_table=11
                     /translation="AITRAQCEYCPESQEFKMHIFPSHTDDDCALELWSLDYKKGVFEE
                     EFGVKLVASLETSVVASVSSLP"
ORIGIN
        1 atgacatcat ttttgtcaac tagagattat actgaaattt taggacaaaa aaaggtatta
       61 agttggcttt tgtactgata ttctggggca agaatgaatc atgggtatca aaattaggcg
      121 atcgctgact aaaaaattcg gtttccaacc ccattttttg acatgatttt aagcacaatt
      181 gcttattgac aaatcattaa taaccttaac ttgtgaccaa tgtggtgcat ctggcaaatt
      241 accttaacac cagattccta tttttctagc tcgagaacgt aataccccag atagagctta
      301 ctatctaagc caaaaacact attgagcatt acaagcggcg caattgtctg ggtaatgagg
      361 aatcgtcatt tctggaacta agggacttgt ccgccacatc cccttagctc ctggttgcat
      421 taagaggctt tttcttctca aagccttgag ctaatgacaa atgtttttgg ttttcctcta
      481 ccttctgctt ctgtgtctca agctcttcag tgtcagtaag atttttctcc tgattaactg
      541 tctgtgtctt tccacactcc agcgctactg cttcttcaac gaagggactg tctgatgatg
      601 gaggctttga actattggtt gaattctgct ctaatcgctc taattgttcc acagaagcgg
      661 gcgtgtagat tacctgccac taccaccaac ctctccttat ccagagattg gaagtactct
      721 tggttcattt gtgataggtc atccttacga gcgtcgattc atgaaaactc agcgtctcgc
      781 tcttgcctca cattaccatc ttttgtgcca agattctttc ctacgtgcaa acttgttaat
      841 tttcttgcca cctgcatcgg ggggggggga gtgaaaggtt acaatttaac aaatcaacta
      901 actattaagt agaagcttta attatgagca acaactttta tcaaaaattt tcggaaatta
      961 gtgctgctcg aagctatttt aaaagtttat gcattgcgga tttattgaaa cagcagtcaa
     1021 aaaaaaatcc tgatgcgatc gccattctta cgcctggacg cgctccactt acttatagtc
     1081 gtttgtggag tcatattcaa gatgttattg ccaaactaaa ttcctttggg attggacgaa
     1141 atgatcgggt agctgttgct ttacccaatg gagcagaaat ggctacagcc tttttatcaa
     1201 tagctgctac tgctacctgt gctcccctca atatagctta tcgtactaat gagtttgaat
     1261 tttatctcaa ggatttaaat gctaaagcct tgattgtcca gtcaaatata gaaacacatg
     1321 cgatcgccgc tgccaagtct ctaagtatcc ccttgattaa actgttacca gtactggagt
     1381 cggaagcagg tatctttgtc ttgaatggat gtgagtctgc aagtagggta actaactacc
     1441 ctgctgatga tgatatagct ttagtactac atacttctgg cacaacatcc cgtccgaaaa
     1501 tagtaccttt gagctatcgc cacctttgca cctcagcgaa taatatttgt actactttac
     1561 aactggtcga gggcgatcgc agtctcaacg tgatgcctct gttccatatt cacggactca
     1621 ttggtgtatt gctatcatct ttaacagcag gagcaagcgt tgtttgcaca ccaggctttt
     1681 tagctcctag tttttttaat tggttctcgg agtttcatcc cacctggtac agtgcagttc
     1741 ccactatgca ccaagcaata ttagctagat ctgaggtagg acgggagatc attgccaaat
     1801 acccaattcg gttgatccgt tcgtcaagtt cttccttacc accccaggta atggcagact
     1861 tagaaaaggt ctttaacgcc cctgtgattg aatcttatgg aatgactgaa gctgcacatc
     1921 aaatggcaag taatccctta ccgccattgt tgcgtaagcc gggttcagtt ggagtagcag
     1981 caggtccaga actagcgatt atggacgagt ctggtaattt gttgcagact gaggaagttg
     2041 gagaaattgt gattcgaggg gcaaatgtta cttcaggata tgaaaataat ccgactgcaa
     2101 atgccaatgc tttcacaaat ggttggtttc gcacaggcga tattggttat ttagacagcg
     2161 acaactattt atttattcag ggaaggatta aagaaattat caatcgaggt ggtgagaaga
     2221 tatcaccacg ggaagttgat gaggtcatac taaatcatcc agcgatcgcc caggtagtta
     2281 cttttgctat cccccatcct caactgggtg aagatgtggc tgttgcagtc gtattgcacc
     2341 aaaatctatc tgtgacagca agagaagttc aggagtttgc agcgttacaa ctggctgatt
     2401 ttaaagtacc agcgaaggtg gtttttttag acgaaatccc taaaggtcca acgggtaaac
     2461 tccaacggat tggtttagcc gagagactag gaattatagt gtccctaaca acagaaacca
     2521 agacagtatt tagtagccca ataacacctg tagaaaaaca gctagctgat atttgggctg
     2581 aggtattggg agttgagcaa attgggattg ataataactt ttttcatttg ggtggagatt
     2641 ctatcctcgc aggcttaatc ctcaaccgca tacgtaaagt tctgcaagta gagttgtctt
     2701 ttttggcatt gtttgaaacc ccaacaatcg cgggtttagc caaaaatttc cctatccaaa
     2761 aggaatcaga ttcggaatca atacaatcta tatccgtaga aatacccatt cgggcagtct
     2821 ttgaatcccc aacagtagct caattagaca aaactatcac ccagttacgt actactgagc
     2881 atggattaac tcttcccccc attcaaccaa taaggggaga cacagaactt ttacccctat
     2941 cttgggcaca acagcgactt tggttcctca accaacttga ggggtcaagt gccacttaca
     3001 acatgccttt ctccctccgc atcactggga acttagatct gaagaccttg caacaagcat
     3061 tatcagaaat aatccgtcgc cattcggtac tacgcactag cttcccgact gtgaatggca
     3121 caccaagaca ggtgattcac ccagaagcca ccatgaacat caatgtggtg gacttacagc
     3181 aactatccgt cacagaacgt gaaactgtcc tacaccaaca agcacaatta gaagcaatta
     3241 ccccctttaa cttggaaaat gcaccattaa tccggtgtag tctgttggag ttatcagcca
     3301 cagagtatgt gttattactg acaatgcacc acattgtttc tgatggttgg tcaatggggg
     3361 tattgatcag ggaactatct gctttatatc cagctttttg tgccggcgtt ccgtccgaat
     3421 taccagaatt accaatccag tatgcagact ttgccgtttg gcaaagacaa tgcttgagtg
     3481 gagaagttct agaaactcaa ctcaattact gggtttctca attgcaaggt gtacccctat
     3541 tgttacaatt acccactgac cgccctcgtg caagggtgca aactcaccag ggtaggactc
     3601 aaagttttag tttaaatagg gatttaaccc agaagttgca aagcttgtca agggcatcag
     3661 gtacgacctt atttatgacc ctgctggcgg cctttgccac tttactttat cgttacagtg
     3721 gtgaatcaga tattgtcatt gggtcaccga tagccaatcg caaccgcagt gaaatcgagt
     3781 tgctgattgg cttttttgtg aatactttgg ttttgagaac ccgttttgaa gccaatccca
     3841 gttttgagaa gttgctttta caagtgaggg aaaccacact ccaagcctat gaacatcagg
     3901 atgtgccttt tgaacaggta gtagaagcat tgcaaccaca acgttctttg agtcattccc
     3961 ccctattcca ggtgatgttt gtattgcaaa atgcacccat aggtgaaatt gaattacctg
     4021 gtgtaacttt gactcagtta aatcgagaaa gcacatttgc taagtttgat ttgacactgt
     4081 caatatcgga aacgaaccac ggattggtag ggtcatggca gtacaatact gacttgttta
     4141 atgagtcaac aattgagcgg atggctggtc atttccagaa cttgttatca gcgattgtgg
     4201 aaaatccaca acaagttgtg ggagaaatcc cgctattaag tgaagcagaa cggcatcagt
     4261 tgttagtgga gtggaatgag acaaagagtg aatatcctac tgataaatac attcatcagt
     4321 tatttgagga gcaagtagag agaacaccct tatctgtggc agtggtgttt gagcatcagc
     4381 agttgacata cctggaatta aatcaacgcg ccaaccaact agcgcatcac ttgcaaagtc
     4441 ttggtgtagg accagaggtg ctggtgggga tatgtgtaga acgttctgtg gagatggtcg
     4501 tgggactgct ggggatactg aaggcaggtg gtgcttatgt cccccttgac cccaattatc
     4561 cgactgaacg cctaagttat atgttggcag attcaggtgt gaaagttttg ttgacacaac
     4621 aacagttgtt gtcatctttg ccgttacata ctgcacaggt agtttttcta gatacggatt
     4681 ggggcttaat agaacaatac tcacatcaga atcttgatgc tgagataggt gcagataatt
     4741 tggtttatgt tatatatact tctggttcta ctggacagcc taagggggtt ttagttgctc
     4801 accaaggatt attaaatcta gttttttggc atcaagcagc ttttggtatt accccatcag
     4861 atatcgccac tcaactagca ggaactgctt ttgatgcatc agcatgggag ttatggcctt
     4921 acctgagtat tggagctagt atacacttgc tcaagataga aactattgtt caaccacaag
     4981 ttttacaaaa ttggctaata tcacaaaaaa ttacgatcac ttttataccc acaccattat
     5041 tagaaagctt gttgttattg gagtggccac cctctattgc tttaagaatt gtcctcactg
     5101 gtggagacaa gcttcatcaa tactcatcaa cttcattacc ctttagagtc attaataatt
     5161 atggaccgac tgaaaatact gttgtcacaa cttctggatt gattgtttca actgaacaaa
     5221 caaatctatt accacctata ggtcgcccca taagtaacac gcaaatctac atcctagacc
     5281 aacgcctaca gccagtaccc ataggggtaa caggagaaat gtacattgga ggcgatgggt
     5341 tagccagagg ctacctcaat cttcctgact taaccaaaca gaagttcatc cccaaccctt
     5401 ttttagggag tagggagtgg ggagtgagga gttatgagtt agaaaataac aatcaacaac
     5461 caacacccaa caaccaacat tattgttcgg tatacctcta caaaacgggc gacttagcat
     5521 gctatttgcc tgatggcaac atcgagtttc tcggtcgtct agatcatcaa gtgaagattc
     5581 gcggcttccg catcgaacca ggagaaatcg aggcggtgct ggcgcaacac cctggtgtgc
     5641 aggaaaccgt ggtcatcacc cacgaatatt caccaggcga caagcaccta gtggcatata
     5701 tcgttcccca ggtagaggtg tcagccacaa cagaagattt gcgccacttt ctcaagcaga
     5761 aattgcccaa ctacatgata ccgtcagtct ttgtccttct ttccacccta cctcttaccc
     5821 ctaatggtaa agtagaccgg agcgctctgt tagttcccga ccaaccaaac tccgaaggga
     5881 aattatttgt agctccccag actctgacgg aggagatgct agcacgtatc tgggctgaaa
     5941 tcctcaacat tgaatctttc actagaggac agagcaatat caatatctac gataactttt
     6001 ttgacttggg tggtcattcc ctggtagcga ctcttctcat tactcgcatc aggcaggttt
     6061 ttcaggtaga tctccctttg tggcgtttgt ttgatgctcc taccatcgca gggctagcgt
     6121 ccagtattga aactgagcgc caaaccaaca tccttaagca tcaaatagaa ccaaagcctt
     6181 ggtctagtct ggttccaatt cagcttggtg gctccaaaag accatttttt ctggtatcag
     6241 gtggcaatgg cagtgaattt aatttaatca attacgcgaa gttagtctac tttttgggac
     6301 aggatcaacc agtttatgga ctaaaaacgc gtggttgcga cccaaaacaa cagcctcaca
     6361 cccaagtgga ggtgatggca tctgactaca ttaaagaaat ccgtactcta caaccctctg
     6421 gtccctacct tctgggtggt gaatgcatag gaggggttgt ggcttttgaa atggcgaggc
     6481 aactggtggc agttggtcaa aaggttggct tattaatttt aatagatact caatatccga
     6541 gtcatgttca ccaaatccgt tactttctca aaagagtcac cgtcaaaata caaaaactaa
     6601 aaagaatccc ctatcattta actaaacttt tgcaacttaa ttcaagagag ttgcaacttt
     6661 acactttcga caaagtacaa acagccaaag aagtctttgt tgagcaaaat tatgccacag
     6721 tcctcatgcg ctacaaaccg cgaccctaca ttggtcgaat gaccttactg gtcaatgagg
     6781 attattatca gaaaaatcca gccataggtt gggatcatgt agctgctgga gggttggaaa
     6841 tccatcaggt accaggagat catgactctt atcttgggaa gtatgtcaaa accacatctg
     6901 acgttttaaa aggttgtcta gacgccgctc aacgtgaatt cgagggttag cttgcacaag
     6961 tttttttcaa aaaaaaagct taaaacccgt ccccacccct ttctgctcaa tggttggcag
     7021 aaggcgggaa tgccagtcta ctggactttg gactaaatta actctcgtag cgcgaaaaag
     7081 cagaggttga ctttcagccg atctatgaat ttgcggtgaa agtccttgag ttgttcaacc
     7141 ggacatgata ttctctgcac cctcggcgtc tctgcggttt gttatcattc agatttaaca
     7201 gggaaaacgt taaaatttcc ccttttccct ttccccgggc tattggctgg tgcgccgcaa
     7261 acggttacgg caaacttgag acagatgcaa ctacagaagt ttctaaactt gccactaatt
     7321 tgacaccaaa ttcttcctca aatacacctt ttttataatc caaactccac agttctaagg
     7381 cgcagtcatc atcggtatga gatggaaaaa tgtgcatctt gaattcctgt gattctgggc
     7441 aatattcaca ctgcgctcgt gtaattgctc
//
