LOCUS       c00650_3300009..       10844 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300009709.a:Ga0116227_10016117.
ACCESSION   c00650_3300009..
VERSION     c00650_3300009..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 08:49:43
            Original ID  :: 3300009709.a:Ga0116227_10016117
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10844
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..600)
                     /locus_tag="ctg650_1"
                     /transl_table=11
                     /translation="MIGNIPLAWLQLARQKVRSVIALAGIAFIVILMFMQLGFQDALYS
                     SATQIHQTLRGDLFLLSSQYKSLTSNQSFPRERLYQVLGFDGVESVSPVYLEFAKFKNP
                     DNGQKYSIYIIGFDPGKPVLNLPEVNQKIDRIKFPNEVLFDRLSRPEFGTIATEFDRGK
                     EPIVEIFTYTGTIGYRVKVGGLFSLGPSFGVDGNLIV"
     protocluster    1..10844
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2790:10843]"
                     /cutoff="20000"
                     /detection_rule="(hglE or hglD)"
                     /neighbourhood="20000"
                     /product="hglE-KS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2791..10843
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(hglE or hglD)"
                     /neighbourhood="20000"
                     /product="hglE-KS"
                     /protocluster_number="1"
     cand_cluster    1..10844
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(hglE or hglD)"
                     /kind="single"
                     /product="hglE-KS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10844
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="hglE-KS"
                     /region_number="1"
                     /rules="(hglE or hglD)"
                     /tool="antismash"
     CDS             complement(633..1910)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 108.2; E-value:
                     7e-33)"
                     /gene_kind="transport"
                     /locus_tag="ctg650_2"
                     /transl_table=11
                     /translation="MNTVGRLTIIMVSSIALATGAASVYSFSRLRSNFEPDPKNAQTNR
                     AILFITSLGRIEPEGEVIRLSTNNNTSGGVARIESLLVKQGDRIHRGQVIALLNDRSLK
                     IAQLEQAKKQVPIYQAKLAQVKAGAKSGDILAQQATIANLKSELAGQRASQNAVIARLQ
                     ADLRDQTLGQTATLAGLQAEFINARLEYQRYKSLKRDGAISASVMDTKRLTSDTAEQHL
                     NEAKANLSRTKQTIIEQINEAKATLKRSTDTLEDQQREARAKLASIAEVRPVDVQLAQS
                     ELDSAISAVKQAQAEKELTDVRSPIDGEVLKIHTKTGEVIGSEGIAEIGKTDQMYVAAE
                     VYQTDIEKVHLGKKATITSTGFTGKIQGTVTEIGKEVNRQNVFSVSPGVDTDRKVVEVK
                     IRINDPADSKRVVGLTNLQVEVAISL"
     CDS             2791..7506
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (19-475). E-value:
                     9.6e-125. Score: 408.5. Matches aSDomain:
                     nrpspksdomains_ctg650_3_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (591-889). E-value: 4.7e-71.
                     Score: 231.3. Matches aSDomain:
                     nrpspksdomains_ctg650_3_PKS_AT.1"
                     /NRPS_PKS="Domain: PP-binding (1187-1257). E-value:
                     7.2e-11. Score: 34.3. Matches aSDomain:
                     nrpspksdomains_ctg650_3_PP-binding.1"
                     /NRPS_PKS="type: PKS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hglE-KS: hglE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 120.6; E-value:
                     1.1e-36)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg650_3"
                     /sec_met_domain="PP-binding (E-value: 7e-12, bitscore:
                     34.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.6e-72, bitscore: 231.3,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="hglE (E-value: 5.9e-226, bitscore: 738.0,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYNSKINRSHSQLQQTPIAIIGMASIFAQARTLQEYWTNIVNK
                     IDCITDVPASHWSVEDYYDPDPKKPDKTYSKRGGFIPDVDFNPMEFGLPPHLLEVTDIS
                     QILGLVVAKEAMEDAGYGESRQFDRERTGVVLGVAQGRQIALPLGARLQYPVWEKVLKS
                     SGLSDEDTQKIVEKIKTAYVSWNENAFPGMLANIVSGRIANRLDLGGMNCVVDAACASS
                     LGALKMAVSELTEYRSDMMITGGVDTDNSILAYMAFSKTPAVTPSDHTKPFDADADGMM
                     LGEGLGMLVLKRLEDAVRDNDKIYAVIKGIGTSSDGRFKSIYAPRPEGQLQALRRAYED
                     AGISPVSVSLIEAHGTGTMAGDPSEFAALKDFFGEDNPKQQHIALGSVKSQIGHTKSAA
                     GAASLIKTALALHHKILPPTINVTKPNPKLKIETTPFYLNTETRPWMLAEEQEKRRAGV
                     SSFGFGGTNYHVVMEEYQSEHDQAYRIHRTAQILLLAEKTPQQLLAKCSETLAQLQSDH
                     KEQYYAELIAGCQTEIPPTSARVGFVAESLTEACKLLQTTIDWLKNKPEATAWEHPQGI
                     HYRSSGMATSRKVVALFSGQGSQYLQMGKELLMNFPEMRQSYGEMDRLLHQDGLKTISE
                     VVFPNPDFDPDQKKAQDAMLQRTEYAQPAIGALSVGLYNILQQAGFKPDFVAGHSFGEV
                     TALWAAGVLSDEDYFFLVKSRGQAMAARTEPNFDPGRMLAVKEDVSRIEPVLKDFPQVS
                     VANYNSQRQVVLAGSTVEIGKVQQALRGKGFATVLLPVAAAFHTPLMGNAQSAFAQASA
                     AVAYRAPSVPVYTNVTGKPYPTDAQSMRKILEIHLSQSVLFNQEIENIYGAGGYCFVEF
                     GPMNILTNLVKEILGDKPHLAVALNGSRQQNSDRCLREAVVKLRVAGLSLSNIDPYQIP
                     VQAPATGQSKLLSVKLNSTNFASEKTKAAFEKALQDGYKVTLPATTTISAMSAVSNGNE
                     KEMPSTSDKLLNSQGVLDSLENTLSQFIQYQRETLQVHGQYLNHQREYTKTFCQLTQQQ
                     NTLLGGKSSPKTAEIKLAVADTLERSMMQFHSHHSETLRIHEQYLQHQAEYSNHFFQGI
                     QQQYSQIIHTESVAPIVLPATPLETDAKQVATLAKSNPLETNAEISELEEPKQLIPEET
                     LHVEKEVASTPSTTIDFASFCQALLGIISDKTGYPVEMLEIDMDMEADLGIDSIKRVEI
                     LGSVQEMYPELANPNLEELAELRTIGQVGKYLASYSASVVPADAPDVEVSLVAFSNDTQ
                     MAVIDHAMPSATIDIDLTKFDRTLLAIVSDKTGYPVEMLELDMEMEADLGINFIKQVEI
                     LEVVHELYPNLPKPNPEELRTIGQIVEYIQASAEVKKKSHVELDKPHQQLDPNIVRSVV
                     KLKALSKPDFWDFALPEGHIGLITDDGSLTAAKLAHSLTEKGWKVVLLSLPQSVIADSH
                     LSTGVNRVVLADLSEEHLQQQLAAIATKYGAIAAFIHLNPPYTPTSESLENLFSTTEAA
                     ILKHVFLIAKHLKEPLNQSATQGNSCFFTVTRQDGELGTTGNINSAIAGGL"
     aSDomain        2848..4215
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg650_3_PKS_KS.1"
                     /evalue="9.60E-125"
                     /label="ctg650_3_PKS_KS.1"
                     /locus_tag="ctg650_3"
                     /protein_end="475"
                     /protein_start="19"
                     /score="408.5"
                     /tool="antismash"
                     /translation="IAIIGMASIFAQARTLQEYWTNIVNKIDCITDVPASHWSVEDYYD
                     PDPKKPDKTYSKRGGFIPDVDFNPMEFGLPPHLLEVTDISQILGLVVAKEAMEDAGYGE
                     SRQFDRERTGVVLGVAQGRQIALPLGARLQYPVWEKVLKSSGLSDEDTQKIVEKIKTAY
                     VSWNENAFPGMLANIVSGRIANRLDLGGMNCVVDAACASSLGALKMAVSELTEYRSDMM
                     ITGGVDTDNSILAYMAFSKTPAVTPSDHTKPFDADADGMMLGEGLGMLVLKRLEDAVRD
                     NDKIYAVIKGIGTSSDGRFKSIYAPRPEGQLQALRRAYEDAGISPVSVSLIEAHGTGTM
                     AGDPSEFAALKDFFGEDNPKQQHIALGSVKSQIGHTKSAAGAASLIKTALALHHKILPP
                     TINVTKPNPKLKIETTPFYLNTETRPWMLAEEQEKRRAGVSSFGFGGTNYHVVMEEYQ"
     aSModule        2848..6561
                     /complete
                     /domains="nrpspksdomains_ctg650_3_PKS_KS.1"
                     /domains="nrpspksdomains_ctg650_3_PKS_AT.1"
                     /domains="nrpspksdomains_ctg650_3_PP-binding.1"
                     /locus_tags="ctg650_3"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       3841..3885
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_3_0001"
                     /evalue="2.00E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="ctg650_3"
                     /protein_end="365"
                     /protein_start="350"
                     /score="10.7"
                     /tool="antismash"
                     /translation="IEAHGTGTMAGDPSEF"
     CDS_motif       3946..3990
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_3_0002"
                     /evalue="3.00E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="ctg650_3"
                     /protein_end="400"
                     /protein_start="385"
                     /score="10.3"
                     /tool="antismash"
                     /translation="GSVKSQIGHTKSAAGA"
     aSDomain        4564..5457
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg650_3_PKS_AT.1"
                     /evalue="4.70E-71"
                     /label="ctg650_3_PKS_AT.1"
                     /locus_tag="ctg650_3"
                     /protein_end="889"
                     /protein_start="591"
                     /score="231.3"
                     /specificity="consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFSGQGSQYLQMGKELLMNFPEMRQSYGEMDRLLHQDGLKTISEV
                     VFPNPDFDPDQKKAQDAMLQRTEYAQPAIGALSVGLYNILQQAGFKPDFVAGHSFGEVT
                     ALWAAGVLSDEDYFFLVKSRGQAMAARTEPNFDPGRMLAVKEDVSRIEPVLKDFPQVSV
                     ANYNSQRQVVLAGSTVEIGKVQQALRGKGFATVLLPVAAAFHTPLMGNAQSAFAQASAA
                     VAYRAPSVPVYTNVTGKPYPTDAQSMRKILEIHLSQSVLFNQEIENIYGAGGYCFVEFG
                     PMNILTNLVKEILGDKPH"
     CDS_motif       4567..4611
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_3_0003"
                     /evalue="6.00E-05"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="ctg650_3"
                     /protein_end="607"
                     /protein_start="592"
                     /score="15.7"
                     /tool="antismash"
                     /translation="FSGQGSQYLQMGKELL"
     CDS_motif       4828..4950
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_3_0004"
                     /evalue="1.30E-12"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ctg650_3"
                     /protein_end="720"
                     /protein_start="679"
                     /score="39.7"
                     /tool="antismash"
                     /translation="GFKPDFVAGHSFGEVTALWAAGVLSDEDYFFLVKSRGQAMAA"
     aSDomain        6352..6561
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg650_3_PP-binding.1"
                     /evalue="7.20E-11"
                     /label="ctg650_3_PP-binding.1"
                     /locus_tag="ctg650_3"
                     /protein_end="1257"
                     /protein_start="1187"
                     /score="34.3"
                     /tool="antismash"
                     /translation="QALLGIISDKTGYPVEMLEIDMDMEADLGIDSIKRVEILGSVQEM
                     YPELANPNLEELAELRTIGQVGKYLA"
     CDS             7522..9435
                     /NRPS_PKS="Domain: PKS_KR (72-295). E-value: 6.3e-44.
                     Score: 141.8. Matches aSDomain:
                     nrpspksdomains_ctg650_4_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /locus_tag="ctg650_4"
                     /transl_table=11
                     /translation="LNKEWEPVFCRAIDLSPDLDASVSVNHILGELHDPNRLLTEVGYS
                     LQGRTTLVTEKKPGFQRNSSLPTSDSIFLVSGGAKGITAQCVIKLAEEYKCKFILLGRS
                     AITEAEPECAKDCWNADLKKRIMENLQSTGEKPTPAAVQKIFNRITSKREIENTLAAIH
                     AGGGQALYMSADVTDAATLQDKLAPVIKRLGAITGIIHGAGNLADKRIEKKTKQDFDTV
                     YTAKVKGLENLLCCVKPSQLEYLVLFSSVTGFYGNIGQSDYAIANEILNKSAYIVKQRY
                     PSCHVVAINWGGWDSGMVTQELKQEFARRSIDIIPVESGTQMLVNELHPTNHGTVQVVI
                     GSPLFPPPAPLDPELRNYSIRRRLSLEANPFLLDHVIAGRPVLPATCAVSWIVDACEQL
                     YPGYRFFSHTDFKFLKGITFNETLASEYILDLQETAKTDSQEILFQAKIWSKTPEGKIH
                     YHFSIDQVQLVRELPTRPTYEQLNLEEDQLIINNGKEFYQKEKSTLFPLFHGVSFQELT
                     RVINISREKITAECVWHEIGDKQKGQFPIGWVNPYSIDLSTHPLWIWMQYFHQEICLPG
                     GIKKYEQFIETPCNTPFYVSCEVKAKTASSVTADFIVHDRQGQVYSRLKGAKGTIVPLD
                     KI"
     CDS_motif       7738..7833
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_4_0001"
                     /evalue="6.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg650_4"
                     /protein_end="104"
                     /protein_start="72"
                     /score="12.5"
                     /tool="antismash"
                     /translation="FLVSGGAKGITAQCVIKLAEEYKCKFILLGRSA"
     aSDomain        7738..8406
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg650_4_PKS_KR.1"
                     /evalue="6.30E-44"
                     /label="ctg650_4_PKS_KR.1"
                     /locus_tag="ctg650_4"
                     /protein_end="295"
                     /protein_start="72"
                     /score="141.8"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="FLVSGGAKGITAQCVIKLAEEYKCKFILLGRSAITEAEPECAKDC
                     WNADLKKRIMENLQSTGEKPTPAAVQKIFNRITSKREIENTLAAIHAGGGQALYMSADV
                     TDAATLQDKLAPVIKRLGAITGIIHGAGNLADKRIEKKTKQDFDTVYTAKVKGLENLLC
                     CVKPSQLEYLVLFSSVTGFYGNIGQSDYAIANEILNKSAYIVKQRYPSCHVVAINWGGW
                     DS"
     aSModule        7738..8406
                     /domains="nrpspksdomains_ctg650_4_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg650_4"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       8245..8334
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_4_0002"
                     /evalue="1.60E-11"
                     /label="PKSI-KR_m4"
                     /locus_tag="ctg650_4"
                     /protein_end="271"
                     /protein_start="241"
                     /score="36.7"
                     /tool="antismash"
                     /translation="LEYLVLFSSVTGFYGNIGQSDYAIANEILNK"
     CDS_motif       8632..8688
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_4_0003"
                     /evalue="7.60E-05"
                     /label="PKSI-DH_m2"
                     /locus_tag="ctg650_4"
                     /protein_end="389"
                     /protein_start="370"
                     /score="15.4"
                     /tool="antismash"
                     /translation="FLLDHVIAGRPVLPATCAVS"
     CDS             9557..10843
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (3-426). E-value:
                     7.7e-79. Score: 257.2. Matches aSDomain:
                     nrpspksdomains_ctg650_5_PKS_KS.1"
                     /NRPS_PKS="type: PKS/NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hglE-KS: hglD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 231.9; E-value:
                     2.3e-70)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg650_5"
                     /sec_met_domain="hglD (E-value: 1.2e-182, bitscore: 595.4,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKIAIIGYSCLLPDANNSEEFWQNLIQQKDSTSSITVEEMGINP
                     QTFYSQTKGKADKFYSLMGGFVRNFKFDPTGYQLPAEVLANLDNTFKWSLHTAKEALKH
                     SGYLENQDILAKCGVILGTLSLPTKYSNQLFSSIYHQVLSPVVTELLQQEFELSSLLTS
                     GEASVYNAMISGLPAAIIAQALCLSSIHFCIDAACSSPQYAIKLASHYLWTHKADLMLA
                     GGISCADPLFIRMLFSGIQGYPEDNDISRPFDKSSRGLVTAEGVGIVVLKRYSDAVRDG
                     DRIYATICGNGLSNDGKGKHLLSPNSKGQILAFERAYAEAQINPKEIDYLECHATGTLL
                     GDTTEFFSTETFFGQYQATPLVGSVKSNVGHLLTAAGAVSLIKVLLSMSKGVIPATINI
                     TDPLGTENNVISPSRIVRSATKWQNHSHLK"
     aSDomain        9566..10834
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg650_5_PKS_KS.1"
                     /evalue="7.70E-79"
                     /label="ctg650_5_PKS_KS.1"
                     /locus_tag="ctg650_5"
                     /protein_end="426"
                     /protein_start="3"
                     /score="257.2"
                     /tool="antismash"
                     /translation="IAIIGYSCLLPDANNSEEFWQNLIQQKDSTSSITVEEMGINPQTF
                     YSQTKGKADKFYSLMGGFVRNFKFDPTGYQLPAEVLANLDNTFKWSLHTAKEALKHSGY
                     LENQDILAKCGVILGTLSLPTKYSNQLFSSIYHQVLSPVVTELLQQEFELSSLLTSGEA
                     SVYNAMISGLPAAIIAQALCLSSIHFCIDAACSSPQYAIKLASHYLWTHKADLMLAGGI
                     SCADPLFIRMLFSGIQGYPEDNDISRPFDKSSRGLVTAEGVGIVVLKRYSDAVRDGDRI
                     YATICGNGLSNDGKGKHLLSPNSKGQILAFERAYAEAQINPKEIDYLECHATGTLLGDT
                     TEFFSTETFFGQYQATPLVGSVKSNVGHLLTAAGAVSLIKVLLSMSKGVIPATINITDP
                     LGTENNVISPSRIVRSATKWQNHSH"
     aSModule        9566..10834
                     /domains="nrpspksdomains_ctg650_5_PKS_KS.1"
                     /incomplete
                     /iterative
                     /locus_tags="ctg650_5"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       10544..10591
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_5_0001"
                     /evalue="1.60E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="ctg650_5"
                     /protein_end="345"
                     /protein_start="329"
                     /score="11.0"
                     /tool="antismash"
                     /translation="YLECHATGTLLGDTTEF"
     CDS_motif       10643..10687
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg650_5_0002"
                     /evalue="1.60E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="ctg650_5"
                     /protein_end="377"
                     /protein_start="362"
                     /score="11.1"
                     /tool="antismash"
                     /translation="GSVKSNVGHLLTAAGA"
ORIGIN
        1 gacaattaag ttgccatcta cgccaaaaga aggacctaag ctaaacaaac ctcctacttt
       61 aactctatag ccaattgtgc ctgtgtaggt aaatatttct actatcggct ctttaccccg
      121 gtcaaattct gtagcaattg taccaaattc aggacgggat agtcggtcga agagaacttc
      181 attaggaaat ttgatccgat ctattttttg gttgacttcg ggtagattaa gaacaggctt
      241 tcccggatcg aagccaatga tgtaaattga gtatttttgc ccattgtctg ggtttttgaa
      301 tttggcaaat tccagatata cggggctgac tgactcgaca ccatcaaatc ccagtacctg
      361 atacaatcgt tcccgtggaa agctttggtt tgatgtcaaa gatttatatt gagaactgag
      421 taaaaataaa tctcctcgta aagtttgatg tatctgggtg gcacttgaat atagtgcgtc
      481 ttggaaacct agttgcataa acatgaggat tacaataaaa gcaatccctg ctaaagcaat
      541 tacagatcta actttttggc gtgctaactg tagccatgct agaggaatgt taccaatcat
      601 ctgatttggg attttaaatt ttggatgttg gattataggc tgatcgcaac ttcaacctgt
      661 aagttggtta agccgacaac tcgtttgcta tctgcaggat cattaatgcg aattttcacc
      721 tcaacgactt tgcgatcggt gtctactccc ggactaacac tgaagacgtt ttgtctgtta
      781 acttccttgc cgatctctgt cacggttccc tgaattttgc ctgtgaaccc agtactggta
      841 attgtcgctt ttttacctaa atgtactttt tcaatatcag tttgataaac ttctgctgct
      901 acatacatct gatctgtctt gccaatttcc gcaatgcctt cactaccgat aacttctcca
      961 gttttggtat ggattttcaa aacttctcca tctattggag atctgacatc agttaattcc
     1021 ttttctgctt gcgcctgttt gacagcgctg atggcactgt ctagttcact ttgtgctagc
     1081 tggacgtcta ccggacggac ttccgcaata cttgctagtt ttgctctagc ttccctttgc
     1141 tgatcttcca gagtgtctgt gctgcgtttc aacgtcgctt tagcttcgtt gatctgctcg
     1201 atgatggttt gctttgtccg acttaggttg gctttggctt cgttgagatg ttgttcggct
     1261 gtgtctgatg tcaggcgctt ggtatccatt acagaagcag aaattgctcc atctcgcttg
     1321 agtgacttat agcgctgata ttcgaggcga gcattaatga attctgcctg tagacctgct
     1381 aaagtcgcgg tttgccctag agtctgatcg cgcagatctg cttgtaaacg tgcgatcacg
     1441 gcgttttgtg atgctcgctg tcctgccaat tctgatttta agttagcgat cgttgcttgt
     1501 tgagcgagga tgtcaccact tttagctccg gctttgactt gagccagttt cgcttggtaa
     1561 attggaacct gttttttagc ttgttctaac tgcgctattt ttaatgaacg atcattaagc
     1621 aacgctatga cttgtccgcg atgaatgcga tcgccctgct ttacgagcaa tgattcaatt
     1681 cgtgccacgc caccagaagt attgttgttg gtagacaatc gaatcacttc gccttccggt
     1741 tctatccgcc ccaaggaggt aataaaaagg atggcgcgat tagtttgggc gtttttggga
     1801 tctggttcaa aattagatcg tagtcttgaa aagctgtaga cagatgctgc tccagtagct
     1861 agagctatac tactcaccat aattatcgtc aaccgaccta cagtgttcat ggactcgcag
     1921 tatggacaat ccgtggaata ccttgaatat tatgcagcac tgaattcttc atgtaaactt
     1981 cataaacata tctagacctt gccatacaag tatgttactt taaaagatag gcataaattt
     2041 tcataatgaa ttgagttgtt ccaagacggt tcggttaagc tcaaaagcat ccttcccttt
     2101 cttaagattg ttttacatat attgtttttt tccacccatg tacctagatt ttttgacgaa
     2161 caaccaagcc gagattgagc ctggacatct agtttaggac ttacgcatcg acaaaaacaa
     2221 tcaaactgaa tggggttttt caatcccatt cagtttgatt gggagcatcc acttttggcg
     2281 gatagacttt tttagatgaa ccatatagta gagtttttgg agtaaaagaa ttatgtttct
     2341 tccaaaagtt gatgctcccg tttgattttg cttgggttgt cacaaacagc ctgaaacgac
     2401 cgaatttcgt tagcacacat gatagtcgat ttgtatagtg cgtaagtcct atagttcagc
     2461 cctttcaagg tggctaaaat ttttgtccaa gaattttccg gctctctgtg ttctctgcgt
     2521 ttggagtggt tcaataaatt actttttaac cgcagaggca cagagaacac agagagaaaa
     2581 gtagaggttt gaccgccaga actaagattt tatgaatcac cttgaaaggg ctagtacacg
     2641 acggcggaaa taaagtaccc ctttcaaaca ggcacaagct ttgatatata acatatataa
     2701 cacttttgaa ttttgacttc cgccttgcgt tactagtcct atagttgtct tttttgtaga
     2761 tgagtaagat tcacttgctt ttaatgtgta atgaaatctt ataattcaaa aattaaccga
     2821 agtcatagcc aattgcaaca aacgcccatc gcgattatcg gtatggcgtc gatcttcgct
     2881 caagccagaa cattgcagga atactggaca aatattgtta acaaaattga ttgtattaca
     2941 gacgttcctg cttcgcactg gagtgtcgaa gattactacg accccgaccc caagaaacca
     3001 gataagactt acagcaaacg gggtggattt ataccagatg ttgattttaa cccaatggaa
     3061 tttgggttgc cacctcatct attagaggtc acagatattt cccagatcct gggcctggtt
     3121 gtcgccaaag aggcaatgga agatgcaggc tacggagaat cccgccaatt tgatcgtgaa
     3181 cggactgggg ttgttttggg ggtagcgcag ggaagacaaa tagcattgcc actaggtgct
     3241 aggttgcagt atccggtgtg ggaaaaggtc ttgaaaagca gtggattatc tgatgaagat
     3301 acgcaaaaaa tcgtcgagaa aataaaaact gcctacgtaa gttggaacga aaatgccttc
     3361 ccagggatgc tggctaacat tgtttctggg cgaattgcca accgcctgga tttgggggga
     3421 atgaactgtg tcgtcgatgc tgcctgtgct agttccttag gtgcgctgaa aatggcagtg
     3481 agcgaactaa ctgaatatcg ctccgacatg atgatcacgg gtggagttga caccgacaac
     3541 tcgatcttgg cgtatatggc tttcagcaaa acccctgctg tgactccgag cgatcatacc
     3601 aaacctttcg atgctgatgc cgacgggatg atgttgggtg aaggtctcgg gatgttggtg
     3661 ctgaagcgtt tagaagacgc tgtcagagac aatgacaaaa tctatgcagt catcaaaggc
     3721 attggaactt ccagtgatgg tcgatttaag agcatctatg cacctcgtcc agaaggacaa
     3781 ctgcaagcct tgcgccgcgc ttacgaagat gcaggcatat cccccgtaag tgtcagctta
     3841 attgaagccc acggcaccgg cacgatggct ggcgaccctt ctgaattcgc tgctttgaaa
     3901 gacttttttg gagaagacaa cccaaaacag caacacattg ccttgggaag cgtgaaatcg
     3961 caaatcggac acactaagtc agcagcaggt gcggcaagct tgatcaaaac tgctttggca
     4021 ctgcatcaca aaatattacc acccaccatt aacgttacta aacccaatcc caagctcaaa
     4081 attgaaacca caccctttta cttgaatacc gaaaccagac cttggatgct ggcagaagaa
     4141 caagaaaaaa gacgagcagg tgtcagttca tttggttttg gtggcactaa ctatcacgtt
     4201 gtcatggaag aataccaaag cgaacacgac caagcttatc gcatacaccg cactgctcaa
     4261 atactgctgt tagctgaaaa gacgccacaa cagttgttgg ctaaatgctc tgaaacactc
     4321 gcccaactgc aatcagacca taaagaacag tactatgccg aattgattgc tggatgtcaa
     4381 acagaaattc ctcctacaag tgcgagagta gggtttgttg ccgaatcttt aacagaagct
     4441 tgcaagttat tgcaaaccac gattgactgg ctgaaaaaca aaccagaagc aacagcttgg
     4501 gaacatcccc aaggaattca ctaccgttct tctggaatgg ctacttctag aaaagtggta
     4561 gctttgttct ccggtcaagg ttcccaatac ctgcaaatgg gtaaggaact gctgatgaat
     4621 tttcctgaaa tgcggcagag ttacggtgag atggataggc tgttgcatca agatggcttg
     4681 aaaactatct cagaagttgt cttcccaaat cctgacttcg acccagatca gaagaaggca
     4741 caggacgcaa tgctacaacg cacagaatac gctcagccag cgattggggc tttaagcgtt
     4801 gggctgtaca acattctgca acaagctgga ttcaagccag attttgtcgc cggacacagt
     4861 tttggagaag taacagcttt gtgggcggct ggagtattga gcgatgaaga ttactttttc
     4921 ctggtgaaat ctaggggtca agcgatggct gcacgcactg agccaaactt tgatcctgga
     4981 aggatgctgg ctgttaaaga agatgtcagc cgcatcgaac ctgtccttaa agatttcccg
     5041 caagtatctg ttgccaatta caattctcaa cggcaagttg tattggctgg atcaacagtg
     5101 gaaattggca aagtgcagca agcgctacga gggaaaggct ttgccacagt gttgctccct
     5161 gtcgccgctg ctttccacac tccgctgatg ggaaacgccc agtcagcttt tgctcaagca
     5221 agtgcagcag tggcatacag agcaccttct gttcctgttt acaccaatgt cactggcaag
     5281 ccttatccca ccgatgctca aagcatgcga aagatcctgg aaatacactt gagtcagtca
     5341 gtgttgttta accaagagat tgaaaatatc tacggtgctg ggggttattg ctttgtggag
     5401 tttggcccga tgaacattct cactaacttg gtaaaagaga tcctgggcga taaaccccat
     5461 ctagctgtgg ctttaaatgg cagccgtcaa caaaatagcg atcgctgtct acgggaggca
     5521 gttgtaaaat tacgtgtcgc cggtttgtct ttaagcaaca tcgatcctta tcaaatccca
     5581 gtccaagcac ctgcaactgg tcaaagcaag ctgttgagcg tgaagttaaa tagtactaac
     5641 tttgcatcag aaaaaaccaa agcagccttt gagaaagctt tgcaagacgg atataaagtg
     5701 acattgcctg ctaccacaac catatctgct atgagtgcag tatccaacgg caacgaaaaa
     5761 gagatgccat caacatcgga caaacttcta aattctcaag gggttttaga cagtttagag
     5821 aacaccctgt cacagtttat tcagtatcaa cgcgagactt tacaagttca cggacaatat
     5881 ctgaaccatc agcgggaata taccaaaact ttctgccaac tgacacagca gcaaaatacc
     5941 ttactaggtg ggaaatcttc accgaaaaca gcagaaatca agctggcggt tgcagatact
     6001 ttagaacgca gcatgatgca gtttcactct caccacagtg aaaccctacg cattcacgag
     6061 caatatctgc aacatcaggc ggaatacagc aaccacttct tccaaggaat acaacaacag
     6121 tattcccaga tcatccatac tgagtcagtc gcaccgatag tattgccagc aacacctcta
     6181 gaaaccgatg ccaaacaggt agcaacactg gcaaaaagca atccactaga aaccaatgcg
     6241 gaaatttctg aattagagga accaaagcaa ctcattcctg aggagacttt acacgtcgag
     6301 aaagaagttg cttcaacgcc ctcaaccact attgatttcg ctagcttttg ccaagctttg
     6361 ttaggcatca tcagtgacaa gacaggctat ccagtagaaa tgctagagat agatatggac
     6421 atggaggcgg atttagggat tgactccatc aaacgagtgg aaattctggg aagcgtacaa
     6481 gaaatgtatc cagaattagc caatcccaat ctcgaagaac tggcagaact gcgtaccatc
     6541 ggtcaagttg gaaagtattt agcatcgtac tctgcgagtg tcgttcctgc tgatgcgcca
     6601 gatgtcgagg tttcactggt ggcattcagt aatgacacgc agatggcagt tatcgaccac
     6661 gccatgccgt cagcaactat cgacattgat ttgaccaagt ttgatcgtac tctgctcgcg
     6721 atcgtgagcg acaagacagg ctatccagta gaaatgttag aattagatat ggagatggaa
     6781 gcagacttgg ggattaactt catcaaacag gtcgaaatcc tggaagttgt gcacgagtta
     6841 taccctaatt tacccaagcc gaatcctgaa gaactgcgta ccatcggtca aatcgtggag
     6901 tacatccaag cttcggctga ggtaaaaaaa aagtcccatg ttgagcttga caagccacat
     6961 cagcaattag atcccaatat cgtccgcagt gttgtcaaac tcaaagcttt atctaaaccc
     7021 gatttttggg attttgcttt accagaggga cacattggct taattaccga tgatggttcc
     7081 ctcaccgctg ctaaattggc tcattccctc acagagaaag gttggaaagt ggtactttta
     7141 agtttacctc aatctgtcat tgccgactcg cacctgagta cgggtgtcaa tcgcgtggtg
     7201 ctggcagatt tgagtgaaga acacttgcaa cagcaactgg cagcgatagc gactaaatat
     7261 ggtgcgatcg ctgcctttat ccatctcaat ccgccataca ccccaacatc agaaagtttg
     7321 gagaatctgt tttccactac agaagccgcc atcctcaagc acgtctttct catcgccaaa
     7381 catctcaaag aaccgttaaa tcaatcagca actcaaggaa acagttgttt ctttacagtg
     7441 actcgccagg atggagagtt gggtacgacg gggaacatca acagtgcgat agcaggtggt
     7501 ttgtagggac tgacaaaaac attgaacaag gaatgggaac cagtcttttg tcgggcgatc
     7561 gacttaagtc ctgatttaga tgcatcagtg tcagtcaacc acatactagg ggaactgcac
     7621 gaccccaatc gattgctaac agaagtcgga tatagcttac agggaagaac caccttagtt
     7681 acggaaaaaa aaccaggatt tcaacggaac tcctcattac ccacttccga ctcaatattt
     7741 ttagtcagcg gcggtgctaa aggaattaca gcacaatgtg tcatcaagct agctgaagaa
     7801 tataaatgca aatttatctt gctggggcgt tcggcgatca ctgaagctga accagaatgc
     7861 gcaaaagatt gctggaatgc cgacttgaaa aagcggatta tggagaatct gcaaagcaca
     7921 ggcgaaaaac ccactcccgc cgcagtgcag aaaatcttca atcgcattac ctccaagcgg
     7981 gaaattgaaa acaccctggc ggcaattcat gctggcggtg gacaagctct atatatgagt
     8041 gcagatgtga ccgatgctgc gactttacag gataaacttg cacctgtaat caagcgtttg
     8101 ggagctatta ctggtattat tcatggcgct ggtaacctag cagataagcg aattgagaag
     8161 aagaccaagc aagattttga tactgtttat actgccaaag ttaagggatt ggaaaatctg
     8221 ctgtgttgtg taaaacctag tcaacttgaa tatttggttc tgttttcttc tgtaacagga
     8281 ttttacggta atatcggaca gtctgattac gcaattgcca atgaaattct caacaaatca
     8341 gcttatatag taaagcaacg ctatccctcc tgtcatgtag tagctattaa ttggggagga
     8401 tgggacagcg gtatggtgac acaagaattg aaacaagagt ttgcccgacg gagtattgac
     8461 attattccgg tggagagtgg aacacaaatg ctggtcaacg aactccatcc aactaatcat
     8521 ggaactgtac aagttgtcat tggtagtcca ctttttccgc ctcctgcacc attagatccc
     8581 gaactgcgaa actacagtat ccgtcgtcgg ctgtcattag aagccaatcc ctttttgctg
     8641 gatcatgtta ttgctggtag acctgtttta ccagctactt gtgcagtgtc atggattgtc
     8701 gatgcttgcg aacaactgta tccaggttat agatttttca gtcacacgga tttcaaattc
     8761 ttgaagggaa ttactttcaa tgaaactcta gcaagtgaat atattttaga tttgcaagaa
     8821 actgctaaaa ctgattctca agaaatcctc tttcaagcaa aaatctggag taaaacccca
     8881 gagggaaaaa ttcattatca cttcagcatt gatcaggttc agcttgtcag ggaactgcct
     8941 actcgtccta cttatgaaca gttaaatctt gaagaggatc aactcattat caataatggt
     9001 aaagaatttt accaaaaaga aaaatcaaca ttgtttccat tatttcatgg tgtttctttc
     9061 caagaactca caagggtgat caatattagt cgagagaaaa ttactgctga atgcgtttgg
     9121 cacgaaatcg gagataaaca aaaaggacag tttccgatcg ggtgggtcaa tccttattca
     9181 attgacttaa gtactcatcc tttatggatt tggatgcagt attttcatca ggagatttgc
     9241 ttacctggag ggattaaaaa atatgaacag tttatagaga ctccgtgcaa tactcctttt
     9301 tacgtttctt gtgaagttaa ggcgaaaaca gcaagtagcg tcactgccga tttcatcgta
     9361 catgatcgcc aagggcaagt atattcacgc ctgaagggag caaagggaac tattgtaccg
     9421 ttagataaaa tctgatttta gttcatgggt tttggttgga ttaggcatct aaaattttgg
     9481 ctggcgatcg cactaaagca agatatcaag gtgtaacgtt cttaagtata aaagtaacaa
     9541 taaaaatttt ataattatgg aaaaaatagc tataattgga tactcttgtt tgctgcctga
     9601 tgcaaataat tctgaagagt tttggcagaa tttaattcaa caaaaagatt caacgtcatc
     9661 aatcacagtt gaagaaatgg gaataaaccc ccaaaccttt tactcacaaa ctaaaggtaa
     9721 agcggataaa ttttactcat tgatgggagg atttgtccgt aattttaagt ttgatccaac
     9781 tggatatcag ctaccagcag aggttttggc aaatttagat aatactttta aatggtcact
     9841 tcatactgcg aaagaagcgt tgaaacatag tggatattta gaaaatcaag atattttggc
     9901 taaatgtgga gttatattag gtactctttc tttacctact aagtactcaa atcaattgtt
     9961 tagttccata tatcaccaag tactatcacc agtagttaca gaactgctac aacaagaatt
    10021 tgagttaagt tcgttgctaa cgtctggtga agcttcggtt tataatgcga tgatatctgg
    10081 cttaccagca gcaattatcg ctcaagcttt atgtttatcc agcattcatt tttgtattga
    10141 tgctgcttgt tcatcaccac aatatgctat aaaactggcg tctcattatc tatggacaca
    10201 taaagctgat ttgatgttag ctggaggtat cagttgtgca gatcctttat ttatacggat
    10261 gttgttttct ggcattcaag gttatccaga agataatgat attagtcgtc cattcgataa
    10321 gtcttcacgc ggattagtta cggctgaggg agtggggatt gttgttttga aacggtatag
    10381 cgatgcagtt cgagatggcg atcgcattta tgctactatc tgcggtaacg gactttctaa
    10441 tgatggcaaa ggtaagcatt tactcagtcc caactctaaa ggacaaatac tagcttttga
    10501 acgtgcttat gctgaagcac aaatcaatcc caaagagatc gattacctag aatgtcatgc
    10561 taccggcact ttgttaggag atacaacaga atttttctct acagaaactt ttttcggtca
    10621 atatcaagca actcccctcg ttggttcagt taaaagcaac gttggtcact tactcactgc
    10681 tgctggtgca gttagtttaa ttaaagtact cttaagtatg tctaagggtg tgattcccgc
    10741 aactattaat atcactgacc ccctaggtac tgaaaataac gttatttcac ctagtcggat
    10801 tgttagaagc gctactaagt ggcaaaacca ttcacattta aaac
//
