LOCUS       c00049_3300011..       14655 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300011493.a:Ga0120857_100012.
ACCESSION   c00049_3300011..
VERSION     c00049_3300011..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 06:27:13
            Original ID  :: 3300011493.a:Ga0120857_100012
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 49625
            Orig. end    :: 64280
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14655
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[54625:59280]"
                     /cutoff="10000"
                     /detection_rule="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /neighbourhood="5000"
                     /product="NAGGN"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9655
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /neighbourhood="5000"
                     /product="NAGGN"
                     /protocluster_number="1"
     cand_cluster    1..14655
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /kind="single"
                     /product="NAGGN"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14655
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NAGGN"
                     /region_number="1"
                     /rules="((TIGR03104 or cds(GATase_7 and Asn_synthase)) and
                     TIGR03103 and (TIGR03106 or Peptidase_M42))"
                     /tool="antismash"
     CDS             700..1011
                     /locus_tag="ctg49_44"
                     /transl_table=11
                     /translation="MNDSIYLSIQNSPRFKELVSKRERFAWILSAIMLGLYSAFILLIA
                     YGPHVLGAKLSPDSSITWGIPLGVGLILSAFVLTAIYVRRANGEFDEMNKAILKEAQQ"
     CDS             1008..2666
                     /locus_tag="ctg49_45"
                     /transl_table=11
                     /translation="MIRRLLATLAFGVFAPAVWAADALTGEVHKQPLNMAAILMFVAFV
                     GATLCITYWASKRNNSASDYYAAGGRITGFQNGLAIAGDYMSAASFLGISALVFTSGYD
                     GLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLGQKEIRTLSASGSLVVVAFY
                     LIAQMVGAGKLIQLLFGLDYHVAVILVGILMCMYVLFGGMLATTWVQIIKAVLLLSGAS
                     FMALMVMKHVNFDFNALFSQAIDVHPKGEAIMSPGGLVKDPISAFSLGLALMFGTAGLP
                     HILMRFFTVSDAKEARKSVLYATGFIGYFYILTFIIGFGAILLVSTNPDFKDAAGALIG
                     GNNMAAVHLADAVGGSVFLGFISAVAFATILAVVAGLTLAGASAVSHDLYASVIKKGKA
                     NEKDEIRVSKITTIALAILAIGLGILFESQNIAFMVGLAFSIAASCNFPVLLLSMYWKK
                     LTTRGAMIGGWMGLVSAVALMILGPTIWVQILGHEKAIYPYEYPALFSMLIAFVGIWFF
                     SVTDKSKAADEERALFFPQFVRSQTGLGASGAVSH"
     CDS             complement(2782..2934)
                     /locus_tag="ctg49_46"
                     /transl_table=11
                     /translation="MGTILIIILILLLIGGLPVFPHSRSWGYGPSGIIGTVLIILLILL
                     LLGKI"
     CDS             3164..3976
                     /NRPS_PKS="Domain: PKS_KR (4-169). E-value: 3.8e-11. Score:
                     34.9. Matches aSDomain: nrpspksdomains_ctg49_47_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     194.8; E-value: 2.8e-59)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_47"
                     /sec_met_domain="adh_short (E-value: 8.9e-35, bitscore:
                     113.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQNRMMITGAGSGLGREIALRWAREGWQLALADVNEAGLKETLVL
                     VSQAGGQGFVQRCDVRDYSQLTALAQACEEKFGGIDVIVNNAGVAAGGFFAELSLEDWE
                     WQLSINLMGVVKGCKAFLPMLERSKGRIINIASMAALMQGPAMSNYNVAKAGVLALSES
                     LLIELRQQQVAVHVVCPSFFQTNLLDSFRGPTPAMKAQVGKLLESSPITAADIAEYIYQ
                     QVAQGQFLILPHEQGREAWKLKQRNPQLIYDEMAVMAEKMRAKAKHAV"
     aSDomain        3176..3670
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg49_47_PKS_KR.1"
                     /evalue="3.80E-11"
                     /label="ctg49_47_PKS_KR.1"
                     /locus_tag="ctg49_47"
                     /protein_end="169"
                     /protein_start="4"
                     /score="34.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="MMITGAGSGLGREIALRWAREGWQLALADVNEAGLKETLVLVSQA
                     GGQGFVQRCDVRDYSQLTALAQACEEKFGGIDVIVNNAGVAAGGFFAELSLEDWEWQLS
                     INLMGVVKGCKAFLPMLERSKGRIINIASMAALMQGPAMSNYNVAKAGVLALSESLLIE
                     LRQ"
     aSModule        3176..3670
                     /domains="nrpspksdomains_ctg49_47_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg49_47"
                     /tool="antismash"
                     /type="unknown"
     CDS             3991..4389
                     /locus_tag="ctg49_48"
                     /transl_table=11
                     /translation="MPLARDLIGYPRALFSWRGIPGVINYVLFFLAAVFEIAGCYAFYM
                     WLRLGKSGWWIAPALLSLTLFALILTRVEAAYAGRAYAAYGGIYIVTSLLWLALVERAR
                     PLGSDWIGALLCVLGASIIVLGPRLQSA"
     CDS             4432..4707
                     /locus_tag="ctg49_49"
                     /transl_table=11
                     /translation="LVGSVYLTGGVLKRSDTPCSLRILSLVEDRSMLVIGREVGEVITI
                     DEKIKVKVLSVEGNVVRFGISAPREIEVHRAEIYRRIAEKMAKNPS"
     CDS             complement(4708..4968)
                     /locus_tag="ctg49_50"
                     /transl_table=11
                     /translation="MRAYFAKPALIMLIPYDQLEAETLTRLIEDFVTRDGTDNGDDTPL
                     ETRVLRVRQALAKKQAFILFDLESQQCQLLAKHDVPKELFD"
     CDS             complement(5001..6185)
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03106"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     Peptidase_M42"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_51"
                     /sec_met_domain="TIGR03106 (E-value: 7.7e-180, bitscore:
                     590.2, seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_M42 (E-value: 1.1e-72, bitscore:
                     237.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEQLPEPDLNYLQKVLLEMLAIPSPTGFTDTIVRYVAERLEELG
                     IPFELTRRGTIRATLKGRKSSPDRAVSAHLDTIGASVRAIQDNGRLSLAPVGCWSSRFA
                     EGSRVSVFTDNGVLRGSVLPLMASGHAFNTAIDQMPVSWEHVELRLDAYCATRADCQTL
                     GIDIGDFVAFDPLPEFTESGHISARHLDDKAGVAALLASLKAIVDSGAQPLIDCHPLFT
                     ITEETGSGAAAALPWDVSEFVGIDIAPVAPGQHSSEHAVSVAMQDSAGPYDYHLSRHLL
                     KLARDNELPARRDLFRYYFSDAHSAITAGHDIRTALLAFGCDATHGYERTHIDSLAALS
                     RLLTAYLLSPPVFASDSHATGSSLESFSHQLEHDTQMESDTRVPAVDSLVGNKG"
     CDS             complement(6200..7945)
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03103"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_52"
                     /sec_met_domain="RimK (E-value: 1.3e-09, bitscore: 31.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03103 (E-value: 9.2e-272, bitscore:
                     895.4, seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAHASPYGQRLVRGQVPSYERLQAQLAGDGSDPHDQPRSLHCGW
                     GRLLIGHTYPDPQSLACALQDERAGERDIALYVAAPQQVLAQAPQQLFLDPSDTLRLWF
                     TDYRPAQRVFRGFRIRRAQNDSDWQAINALYLARNMLPVDPALLTPRHLGGPVYWLAED
                     EDTGAVIGSVMGLNHHKAFADPEHGSSLWCLAVDPHCTRPGVGEVLVRHLIEHFMSRGL
                     SCLDLSVLHDNRQAKRLYAKLGFRTLPTFAIKRKNGINQTLFLGPGPQTGLNPYARIIV
                     EEAYRRGIEVQVDDADAGLFTLSLGGRRVRCRESLSDLTSAVSMTLCQDKSLTHKVLKN
                     AGLQLPAQQLAGNADDNLAFLEDHGAVVVKPLDGEQGQGVAVNLTSLEEISQAVENARR
                     FDSRVLLESFHEGLDLRIVVIGFEVVAAAIRHPAHIVGDGQQAVGALIEAQSRRRQSAT
                     GGESRIPLDDETQRTLHAAGVDYDTVLPAGQRLAVRRTANLHTGGCLEDVTERLHPTLA
                     DAAIRAARALDIAVVGLDLMVTAADQPDHVFIEANERAGLANHEPQPTAERFVDLLFPH
                     SRPAP"
     CDS             complement(7949..9655)
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     Asn_synthase"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     GATase_7"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03104"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 576.7; E-value: 9.2e-175)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_53"
                     /sec_met_domain="Asn_synthase (E-value: 4.7e-85, bitscore:
                     279.5, seeds: 78, tool: rule-based-clusters)"
                     /sec_met_domain="GATase_7 (E-value: 1.3e-43, bitscore:
                     141.1, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03104 (E-value: 1.9e-284, bitscore:
                     937.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHHLAPRGPDAWGFHSQGPIALGHRRLKIMDLSDGSAQPMVDSQ
                     LGLSLAFNGAIYNFPELRRELEDLGYGFYSDGDTEVLLKGYHAWGADLLPRLNGMFALA
                     IWERDTQHLFLARDRLGVKPLYLSRNGERLRFASSLPALLKGGDINPMLDPVALNHYLN
                     FHAVVPAPRTLLANVQKLAPATWMRIDAQGRVEQQVWWQLQYGPRTDELDLSLEDWRDR
                     VLDSTREAVAIRQRAAVDVGVLLSGGVDSSMLVGLLREVGVEDLSTFSIGFEDAGGERG
                     DEFQYSDLIARHYGTRHHQLRIDEREIIEQLPAAFRAMSEPMVSHDCIAFYLLSREVAK
                     HCKVVQSGQGADELFAGYHWYPQVDGASNPYAAYRDAFFDRSFADYAETVQQPWRLEHD
                     AAGDFVRHHFAQPGASDAVDKALRLDSTVMLVDDPVKRVDNMTMAWGLEARTPFLDYRL
                     VELSARIPARFKLPDGGKQVLKEAARLVIPSEVIDRKKGYFPVPGLKHLQGATLDWVRE
                     LLLDPSQDRGLFEPAALDRLLSDPHGQLTPLRGSKLWQLAALNLWLSEQGI"
     CDS             complement(9902..11905)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103:FAD dependent oxidoreductase (Score: 125.4;
                     E-value: 5.3e-38)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_54"
                     /transl_table=11
                     /translation="MTEVTQYAQIDWDEQGRPHSRQFDDIYFSKDQSLEETRHVFIDQN
                     DLRQRFSTMAPEQCLVIGETGFGTGLNFFCAWQLFNECANADARLHFISVEKYPLSHAD
                     LARALALWPELAPFSAALLAQYVAVHDGFQTFVFDQGRVRLTLMIGDALEQLPQLDAEI
                     DAWFLDGFAPAKNPQMWTPELFTQIGRLCAANATLGTFTSTGWVRRGLIAVGFEMKRIP
                     GIGKKWEVLRGVFRGTPDIQDNTASVAPWFARPPALNGPRQALVIGAGLAGCASAASLA
                     ARGWQVSVLERHATVAAEASGNPQGVLYLKLSAHGTALSRLILSGFGYTRRLLQCLQRG
                     QDWDACGVLQLAFDSKEEQRQETLANAFDPQLLQRLSREQAQAVAGVALASGGLFYPQA
                     GWAHPPALCQAQLQHPNITLLPHHQVMQLRKVDGLWQAWESEKFLASAPVVVLATAAEI
                     QRFEPCAGLPLKRIRGQITRLPATARSQTLNTVVCADGYVAPSRGGEHTLGASFDFHSI
                     DTTPTVEEHIGNLHLLDEISSDLAERLDTHQIDPHTLQGRAAFRCTSPDYLPIVGPLAD
                     RQTFDQQYTVLAKDARQVPETPCPWIEGLYINSGHGSRGIITAPLSGEMIAAWIDNAPL
                     PVPRDVAEACHPNRFMLRELIRGKKTAPTPKP"
     CDS             12043..13536
                     /locus_tag="ctg49_55"
                     /transl_table=11
                     /translation="MFESAEIGHAIDKETYDAEVPALREALLEAQFELKQQARFPVIVL
                     INGIEGAGKGETVKLLNEWMDPRLIEVRTFDQQTDEELARPPAWRYWRALPAKGRMGVF
                     FGNWYSQMLQGRVHGHFKDAVLDQAIRGAERLEEMLCDEGALIFKFWFHLSKKQMKARL
                     KALKDDPLHSWRISPLDWQQSQTYDRFVRFGERVLRQTSRDYAPWHVIEGVDPHYRSLA
                     VGRILLEGLQAALKVQHAPIHRAHVAPLGESIDERSLLGSLDMTLRLDKSEYQEQLITE
                     QARLAGLLRDKHMRRHALVAVFEGNDAAGKGGAIRRVAAALDPRQYRIVPIAAPSEEER
                     AQPYLWRFWRHVPARGKFTVFDRSWYGRVLVERIEGFCSQADWMRAYGEINDFEEQLTD
                     AGVVLVKFWLSIDEQTQLERFQEREKIPFKRFKITEEDWRNREKWGQYAEAVGDMVDRT
                     STEIAPWTLVEANDKRWARVKVLRTINNALEAAFKKDKK"
     CDS             13648..14604
                     /gene_functions="transport (smcogs) SMCOG1166:transporter,
                     EamA family (Score: 88.6; E-value: 7.7e-27)"
                     /gene_kind="transport"
                     /locus_tag="ctg49_56"
                     /transl_table=11
                     /translation="MHISSGRWVYGLSLSLLTALLWGILPIKLKQVLQVMDPVTVTWFR
                     LLVSGGLLFAWLAASKRLPSFNRLGRKGWGLVALATGGLVGNYVLYLMGLNLLSPGTAQ
                     LVVQLGPVLLLVASVILFKERFSLGQGVGLLILLMGFGLFFNQRLEELLTSLSVYTTGV
                     LTIILATTIWVFYALSQKQLLTVWNSMQVMMVIYLCCAVLLTPWVHPLEALQLNPLQGW
                     LLLACCLNTLVAYGAFAEALAHWEASKVSATLALTPLVTFVAVALAAWFWPDYVHAEQI
                     NTLGYIGAMVVVVGSVLTALGPSLLAGWRARRVRLAR"
ORIGIN
        1 gtccccgagt acgtcaaggc acaatcgctg gccgatctga agactgacga cagcttcaaa
       61 cacaaaatcg tcggcatcga tgcaggctcg ggggtgatgc tcaagaccga tcaggcgatc
      121 aaggactacg acctgaccgg ctacaaactg caggccagct ccggcgcagc gatgaccgcc
      181 gaactgggcc gcgcctatgc caagcagcaa tccatcgccg tcaccggttg ggtgccgcac
      241 tggatgtttg ccaagtggaa actcaagttc ctcgacgatc cgaaaggcgt ttatggcgcc
      301 gctgaaacgg tcaacagcat cggcagtaaa gacctggaca agaaggcgcc cgaagtcgcg
      361 gccttcctga agaagttcca atggcagtcc aaggatgaaa tcggcgaggt catgttggcc
      421 attcaagagg gcgcaaagcc tgaagctgca gccaaggaat gggtggccaa acaccccgaa
      481 cgcgtcgcgg aatggatcgc caaataatag cctgaagcct ctatcgcgca gcttccaggg
      541 ccgcagcact gacaacagtg ctgcggccct tgtcgttcct ggctattacc gaatcggtaa
      601 aacagttttg catctaagac taaggtcgtc tggagtgcgt ccaaaggcag cataaagtgg
      661 agcgggtact acctaatctg tgctgcgagg acaaaaacaa tgaacgacag catttatctc
      721 tcgatacaaa acagcccgcg gttcaaggag ctggtgtcaa aacgtgaacg tttcgcctgg
      781 attctctcgg cgatcatgct cggtctctac tccgctttta tcctgttgat cgcttatggc
      841 ccgcatgtat tgggtgccaa gctcagccct gactcttcga ttacctgggg aatccccctc
      901 ggtgttggcc tgatcctttc ggcattcgtg ctgacggcga tctatgtgcg tcgcgccaac
      961 ggcgagttcg acgagatgaa caaagcgatt ctcaaggagg cacagcaatg atccggcgtc
     1021 ttctggcaac tctggccttc ggcgttttcg cacctgccgt ctgggccgcc gacgccctta
     1081 ccggcgaggt gcacaagcaa cctttgaaca tggctgcgat cctcatgttc gtcgccttcg
     1141 tcggtgcaac gctgtgcatc acctactggg cttccaagcg caacaattct gcctccgact
     1201 actacgcagc cggcggccgt atcaccggtt tccagaacgg cctggcgatt gccggtgact
     1261 acatgtcggc agcctccttc ctgggtattt ccgccctggt gttcacctct ggctacgatg
     1321 gcctgatcta ctcgatcggc tttctggtcg gctggccgat cattctcttc ctgattgccg
     1381 agcgcctgcg taacctcggt aaatacacct ttgccgacgt cgcctcgtat cgccttggcc
     1441 agaaggaaat ccgcaccctg tcggcctcag gctcgctggt ggtggtggcg ttctacctga
     1501 tcgcgcaaat ggttggtgct ggcaagctga tccaactgct gttcggtctg gactaccatg
     1561 tcgcagtgat tctggtcggt atcctgatgt gcatgtacgt gttgttcggc ggcatgctgg
     1621 cgaccacctg ggtacagatc atcaaggctg tgctgctgct ctccggtgcc agcttcatgg
     1681 ccctgatggt gatgaagcac gtcaacttcg acttcaacgc cttgttctcg caagccattg
     1741 atgttcaccc taaaggtgaa gcaatcatga gccctggcgg attggtcaaa gatcctattt
     1801 cggcgttctc gctcggtctg gcactgatgt tcggtaccgc tggcctgccg cacatcctga
     1861 tgcgcttctt caccgtcagc gatgccaagg aagcacgcaa gagcgttctc tacgcgactg
     1921 gtttcatcgg ttacttctac atcctgacgt tcatcatcgg cttcggcgcg attctgctgg
     1981 tcagcaccaa cccggacttc aaggacgctg ctggcgcctt gatcggcggc aacaacatgg
     2041 ctgcggtaca cctggccgac gccgtcggtg gcagcgtgtt cctcggcttc atctcggcgg
     2101 ttgccttcgc gaccatcctg gctgtagtgg ctggtctgac cctggccggt gcttcggcgg
     2161 tgtcccacga cctgtacgcc agtgtgatca agaagggcaa ggccaacgag aaggatgaga
     2221 tccgtgtatc gaagatcacc actattgccc tggcaattct ggcgatcggc ctgggtatcc
     2281 ttttcgaaag ccagaacatc gccttcatgg ttggcctggc attctcgatt gctgccagct
     2341 gcaacttccc ggtattgctg ctctcgatgt actggaaaaa gctgaccacc cgtggcgcca
     2401 tgatcggtgg ttggatgggg ctggtgagtg ccgtggcact gatgattctc ggcccaacca
     2461 tctgggtgca gatcctcggt cacgagaaag cgatctaccc gtacgagtac ccggcactgt
     2521 tctcgatgct cattgccttc gttgggatct ggttcttctc ggtcactgac aagtccaagg
     2581 cagctgacga ggaacgtgcg ttgttcttcc ctcagtttgt tcgctcgcag actggcctgg
     2641 gtgccagcgg tgcagtctct cactaagtaa aaaaggcagt ccctgggtcc agggcctgcc
     2701 ttttcagtga ccggcagaac gcttcaagcc gcacgtcacc gcagtattcg tactgcgttg
     2761 gcttgcggct ttttgctgcg tctagatttt ccctagtagc aacaggatca acagaataat
     2821 aagaaccgta ccgatgatac cggacgggcc atagccccaa cttctggagt gcgggaagac
     2881 gggtaaacca ccgatcagca gcagtatcag aatgatgatg agtatggtgc ccatggcaat
     2941 ttccttgttt gacttgaggg agtaggcgta tcggtacaat ccatctattc ggtcatgggt
     3001 ttcatgtccg cttgttaatt ccgactgctt tgcgcagcga aaagtttaat tctgctttca
     3061 tcgctgtttg cctgtgccat tcagcatcct gatagagcgt gggggctgcc catgccttcg
     3121 ctacactggc gctaactttc agaacggtac aaggcatccg tctatgcaaa atcgcatgat
     3181 gattactggc gcaggctcgg gcctgggtcg ggagatcgcg ctacgttggg cgcgcgaggg
     3241 ctggcaactg gcgttggcgg atgtcaacga ggctggcctc aaggaaaccc tggtattggt
     3301 cagtcaggcg ggcggccagg gtttcgtgca gcgctgcgat gtgcgcgact acagccaact
     3361 gactgcactg gcccaggcct gcgaggaaaa gtttggcggt atcgacgtca tcgtcaacaa
     3421 cgcaggtgtt gctgccggtg gcttctttgc tgagttgtcg ctggaggatt gggagtggca
     3481 gctgtcgatc aacctgatgg gcgtggtcaa gggctgcaag gcatttctac cgatgctcga
     3541 acgcagcaaa ggccggatca tcaatattgc ctcgatggcg gcgttgatgc aggggccggc
     3601 catgagcaac tacaacgtgg ccaaggcggg tgtgctggcg ctttcggaaa gcctgttgat
     3661 tgagctacgc cagcagcaag tcgccgtgca cgtggtgtgt ccgtcgttct tccagaccaa
     3721 cctgctggac tcgttccggg gcccgacccc ggcgatgaag gcgcaggtcg gcaagctgct
     3781 tgaaagttcg ccgattaccg ccgccgatat agccgagtac atctaccagc aggttgctca
     3841 gggccagttc ctgattctgc ctcacgagca gggacgcgaa gcctggaagc tcaagcagcg
     3901 caacccgcaa ctgatctatg acgagatggc cgtcatggca gaaaaaatgc gcgccaaagc
     3961 caagcacgcc gtgtaataca ggcggggtgc atgccactgg cgcgggacct gatcggctat
     4021 cctagggccc tgttcagttg gcgcgggatt cccggtgtga tcaattacgt gttgtttttt
     4081 ctggcggcgg tttttgaaat cgccggttgc tacgcctttt acatgtggct gcgattaggc
     4141 aaaagcggct ggtggattgc gccagcgctt ttgagcctga ccctgttcgc gctgattctg
     4201 acgcgcgtcg aagcggctta tgccgggcgc gcctacgccg cctacggtgg gatctatatc
     4261 gtcacttcat tgctctggct ggcgctggtc gagcgggcgc ggcccttggg tagcgactgg
     4321 atcggtgcgt tgctgtgtgt gctgggcgca agcatcatcg tgctggggcc acggttgcag
     4381 agtgcctgag ctggctcaga cgtcgaaaat ctgtaggagt tatcgccagc tttggtggga
     4441 tcggtctatt tgaccggcgg agtattgaag cgctctgaca ccccgtgcag tctccgaatt
     4501 ctcagcttag tggaggatcg gagcatgttg gtaataggcc gcgaagttgg cgaagtcatc
     4561 actattgacg agaaaatcaa ggtcaaggtg ctgtcggtgg agggcaatgt ggtgcgcttt
     4621 ggtatcagtg caccccgtga aatcgaagtg caccgcgccg agatctaccg acgaatagcc
     4681 gaaaagatgg ccaagaaccc gagttgatca gtcgaacaat tccttgggca cgtcgtgctt
     4741 ggctaacagc tggcattgct ggctttccag atcgaagagg ataaacgcct gtttcttcgc
     4801 cagcgcttgg cgtacgcgca acacgcgggt ttccagcggc gtgtcgtcac cgttgtcggt
     4861 gccgtcgcgc gtgacgaagt cctcgatcag gcgggtgagg gtttcggctt ccagttggtc
     4921 gtagggaatc agcataatca gcgcaggttt ggcgaaataa gcccgcatgc tacgccaaac
     4981 ctgcccttac tgtgtaggcg ctaacccttg ttgcctacca gactgtcgac tgccggcacg
     5041 cgcgtgtcac tttccatctg ggtgtcgtgt tccaactgat ggctgaagct ttccagggaa
     5101 ctgccggtgg cgtgcgaatc gctggcgaac accggcggac tgagcaggta ggcggtcagt
     5161 aaccggctca gggcagccag gctgtcgata tgcgttcgtt cgtaaccgtg ggtggcatcg
     5221 caaccaaaag ccaataacgc agtgcgaata tcgtggcctg cggtaattgc cgagtgggca
     5281 tcgctgaagt agtagcgaaa caggtcgcgg cgcgcaggca gttcgttgtc gcgggcaagt
     5341 ttgagcaaat gccgtgacaa gtgatagtca tagggccccg ccgagtcctg catggcgacg
     5401 ctcacggcat gctcgctgga gtgttgaccg ggggcgacag gcgcaatgtc gataccgacg
     5461 aattcgctga cgtcccaggg caaggcagcc gccgcgcctg agccggtttc ctcggtgatg
     5521 gtgaacagcg gatggcagtc gatcaagggt tgtgcgccgc tgtcgacgat ggccttgagt
     5581 gacgccagca gtgctgcgac gccggccttg tcgtccaggt gacgggcact gatatggccg
     5641 ctttcggtaa attccggcaa tggatcgaag gccacgaagt cgccgatgtc gatccccagg
     5701 gtctggcaat cggcacgggt ggcgcagtag gcatccaggc gcaattcaac atgctcccaa
     5761 ctcactggca tctggtcgat ggcggtgttg aaggcgtgtc cgctggccat cagcggcaac
     5821 acgctgcccc gcagtacccc gttgtcggtg aagacgctga cgcggctgcc ttcggcgaag
     5881 cggctcgacc agcagcctac cggcgccagc gacagcctgc cattgtcctg gatcgcccgc
     5941 acgctggcgc cgatggtgtc cagatgcgct gagacggcgc ggtccggcga gctcttgcga
     6001 cctttcaggg ttgcgcgaat ggtaccgcgg cgggtcagtt cgaaggggat accgagttct
     6061 tccagacgct cggcaacata gcgcacgatg gtgtcggtaa aaccggtggg gctggggatg
     6121 gcgagcatct ccaacaagac tttttgcagg taattgaggt caggttccgg tagctgttca
     6181 gccatgtatc ctcctgtgct cagggtgccg gccggctgtg tggaaacagc aggtcgacga
     6241 agcgttcggc agtgggttgt ggctcgtggt tagccagtcc ggcgcgttcg ttggcttcga
     6301 tgaaaacgtg gtcgggctgg tcggcggcgg tgaccatcag gtcgaggccg acgaccgcaa
     6361 tgtccagggc gcgcgcggcg cggatcgccg cgtcggccag ggtcgggtgc aggcgctcgg
     6421 tgacgtcctc caggcaaccg ccggtgtgca gattggcagt gcgtcgtacc gccaggcgct
     6481 ggccggcagg caacacggtg tcgtagtcga ccccagccgc gtgcagggtg cgctgggttt
     6541 cgtcgtcgag cggaatgcgg ctctcgccgc cggtagcgct ctggcggcgt cggctctggg
     6601 cttcgatcag cgcgccgact gcttgttggc cgtcgccgac aatgtgcgca ggatggcgta
     6661 tggcggcagc caccacttcg aaaccaatga ccacgatgcg caggtccagg ccttcgtgga
     6721 agctttccag caacacacga ctgtcgaagc gccgggcgtt ttccaccgcc tgactgatct
     6781 cttcaaggct ggtgaggttg acggccaccc cctggccttg ctcaccatcc aggggtttga
     6841 ccaccaccgc gccatggtct tcgagaaagg ccaggttgtc gtcggcgttg cccgccagtt
     6901 gttgcgccgg caattgcagg ccggcgttct tcagtacctt gtgggtcagg ctcttgtcct
     6961 ggcacagggt catgctcacg gcgctggtga ggtcgctcaa cgactcgcgg cagcgtaccc
     7021 gccgaccgcc caggctgagt gtgaacagac cggcgtcggc gtcatcgacc tgtacctcaa
     7081 tgccgcgtcg gtaggcttcc tcgacaatta tgcgggcata ggggttgagc ccggtctgcg
     7141 gacctgggcc gaggaacaaa gtctggttga tgccgttttt gcgtttgatc gcgaaggtcg
     7201 gcagggtgcg aaagcccaat ttcgcataca aacgcttggc ctggcggttg tcgtgcaaca
     7261 ccgaaagatc gaggcaactc aagccgcgac tcatgaaatg ctcgatcaag tgccgcacca
     7321 gcacttcgcc caccccaggc cgggtgcaat gtgggtcgac cgccaggcac cagaggctgc
     7381 tgccgtgctc gggatcggca aaagccttgt gatgattcaa gcccatcacg ctgccgatca
     7441 ccgcgcccgt atcttcatct tcggccaacc agtacaccgg gccgccgagg tggcgcgggg
     7501 tgagcagcgc cggatcgacc ggcagcatgt tgcgagccag gtacagggcg ttgatggctt
     7561 gccagtcact gtcgttctgc gcacggcgga tacgaaaacc acgaaacacc cgctgtgccg
     7621 gacggtagtc agtgaaccac aggcgcagcg tgtcggaagg gtcgaggaat aactgctggg
     7681 gcgcctgggc caacacttgt tgaggggcgg ccacatacag ggcgatatcg cgttcgccgg
     7741 cacgctcatc ctgcaacgcg caggcaaggc tttgcgggtc gggataggtg tgaccgatca
     7801 gcaagcgtcc ccagccgcaa tgcagcgaac gcggttggtc gtgaggatcg ctgccatcgc
     7861 cagccagttg cgcctgcaga cgctcgtagg acggtacctg gccgcgaacc aggcgctgac
     7921 cataaggtga agcgtgggct ttcatcgatc agattccttg ttcgctgagc cacaggttca
     7981 aagccgccag ttgccagagc ttcgaaccgc gcagcggcgt caattggccg tgagggtcgc
     8041 tgagcaggcg gtccagggcg gccggttcga acaggccgcg atcctggctt gggtcgagca
     8101 acagttcgcg cacccagtcc agcgtggcac cttgcaaatg cttgaggccc ggtaccggga
     8161 agtagccttt cttgcgatcg atgacttcgc tggggatcac caggcgtgcc gcttccttga
     8221 gcacctgctt gccgccatcg ggcagtttga agcgtgccgg gatgcgcgcc gacagttcca
     8281 ccaggcggta atcgagaaac ggcgtgcgag cctccaggcc ccaggccatg gtcatgttgt
     8341 cgacgcgttt gaccgggtca tcgaccagca tcactgtgct gtccagacgc agggccttgt
     8401 ccacggcgtc gctggcgccg ggttgagcga agtgatggcg gacaaagtcg ccggcagcgt
     8461 catgctcgag tcgccacggc tgttgaaccg tctcggcgta gtcggcaaag ctgcggtcga
     8521 aaaaggcgtc gcggtaggcg gcataagggt tcgatgcacc atcgacctgc gggtaccagt
     8581 gataaccggc gaacaactcg tcagcgccct ggccgctttg caccactttg cagtgtttgg
     8641 ctacctcccg tgacagcagg taaaacgcga tacagtcgtg gctgaccatc ggctcgctca
     8701 tggcgcggaa tgcagccggt agttgctcga tgatttctcg ctcgtcgata cgtaactgat
     8761 gatggcgtgt gccgtaatgg cgtgcgatca ggtccgagta ttggaattcg tcgccgcgct
     8821 cgccaccggc atcttcgaag ccgatggaaa aggtcgacaa gtcttccacg cccacttcgc
     8881 gcagcagccc gaccagcatg ctcgaatcaa cgccaccgga cagcaggacg ccgacatcga
     8941 cggctgcccg ctgacgaatc gccacggctt cgcgggtgct gtcgagtacg cggtcacgcc
     9001 agtcttccag gctcaggtcc agctcgtcgg tgcgcgggcc atattgcaac tgccaccata
     9061 cctgctgctc aacacggcct tgggcatcga tacgcatcca ggtagccggc gccagcttct
     9121 gcacattggc cagcagggtg cgcggtgcag gcaccaccgc atggaaattc aggtaatggt
     9181 tgagcgctac cgggtcgagc atcgggttga tgtcaccgcc tttcaacaag gccggcaggc
     9241 ttgaggcgaa gcgcagacgc tcgccgttgc gcgacaggta tagcggcttg accccgagac
     9301 ggtcgcgggc aagaaacagg tgttgggtgt cgcgctccca gatcgccagg gcaaacatgc
     9361 cattcaggcg cggcagcaaa tcggcgcccc aggcatggta gcccttgagc agcacttcgg
     9421 tgtcgccgtc tgaatagaac ccgtagccga ggtcttccag ctcgcgacgc agttcaggga
     9481 agttataaat ggcgccattg aaggccagtg ataaacctaa ttgactgtcg accatgggct
     9541 gcgccgagcc gtcggacagg tccatgattt tcagccgacg atggcccagc gcaatcgggc
     9601 cctggctatg aaagccccag gcatccgggc cacgaggtgc caggtgatgg gtcattcgct
     9661 cgaccgcggc gaggtccgcc gggcgtggtg gatgggcaac aggggtaaaa cgaaactctc
     9721 cagctaatcc gcacataagt ccttaccggt tttgccgttg gggaaggtgc ccaaaacgcg
     9781 ggcacattga aactgaccga gcgggctggc gagagtttta gaacgattgg ttatatgtgg
     9841 tagcgacgag ctttgagctg caagactgca agcgggaggt gccgcttgca gtacttctag
     9901 ctcagggctt gggggttggc gctgtttttt ttccgcgaat caactcgcgc agcatgaagc
     9961 ggttggggtg gcaggcttcg gctacgtcgc gcgggactgg cagtggtgcg ttgtcgatcc
    10021 aggcggcgat catttcgccg gacagcggcg cggtgatgat tccgcgcgag ccgtggccgc
    10081 tgttgatgta caagccttcg atccaggggc agggcgtctc tggcacctga cgggcatcct
    10141 tggccaggac ggtgtattgc tggtcgaacg tttgtcgatc ggccagcggg ccgacgattg
    10201 gtagatagtc tgggctggta cagcggaagg ctgcgcgtcc ctgcagggtg tgtgggtcga
    10261 tttggtgggt gtcgaggcgt tcggcgaggt cgctggagat ttcatcgagc aggtgcaggt
    10321 taccgatgtg ctcttcgacg gtgggggtcg tgtcgatgct atggaagtcg aagctggcgc
    10381 ccagggtgtg ctcgccgcct cgtgacggtg caacgtagcc gtcggcgcat accacggtgt
    10441 tcaaggtctg gcttcgggcg gtagctggca agcgggtgat ctgcccgcgt atgcgcttga
    10501 gcggcaggcc ggcgcaaggt tcgaagcgct ggatttcggc ggcagtggcc agcaccacca
    10561 ccggtgcact ggcgaggaat ttctcgctct cccaggcctg ccacaggcca tcgacttttc
    10621 gcagttgcat cacttggtgg tggggcagca aggtgatatt ggggtgctgc agttgcgcct
    10681 ggcacaacgc cggtggatgc gcccaccccg cctgcgggta gaacaatccg ccactggcca
    10741 gggctacgcc ggccacagcc tgcgcttgct cgcgactcag gcgctgcagc agttgcgggt
    10801 cgaaggcgtt ggccagggtt tcctggcgtt gctcttcctt gctgtcgaaa gccagttgca
    10861 gtacaccgca ggcgtcccaa tcctgccccc gctgcaggca ttgcagcagg cgtctggtgt
    10921 agccgaaacc actcaggatc agacgcgaca acgccgtgcc atgggccgaa agcttgaggt
    10981 agagcacccc ttgtggattg cccgaggctt ctgcagccac ggtcgcatgg cgttccagca
    11041 cgctgacctg ccagccccgt gcggcaaggc tggcggcgct ggcacacccg gcaaggccgg
    11101 cacctatgac cagggcctga cgtgggccgt tcagggcagg agggcgggcg aaccagggcg
    11161 cgacgctagc cgtgttgtcc tggatatcgg gggtgccacg aaagacccca cgcagtactt
    11221 cccacttctt gccgataccc gggatgcgct tcatctcaaa gcctacggca atcaggccgc
    11281 ggcgcaccca gccggtgctg gtgaacgtgc cgagggtggc gttggcagcg cagaggcggc
    11341 caatttgagt gaacagttcc ggtgtccaca tctgcggatt cttcgccggg gcgaagccgt
    11401 cgaggaacca ggcgtcgatc tcggcatcga gttgtggcag ttgctccagg gcatcaccaa
    11461 tcatcagggt caaccgcacc cggccctgat cgaagacgaa ggtctggaag ccatcatgca
    11521 ccgccacgta ttgcgccagc agcgcagcac tgaaaggcgc caactccggc cacagggcca
    11581 aggcacgagc gaggtcagca tgactgagcg ggtacttttc cacactgatg aaatgcaggc
    11641 gggcatcggc gtttgcgcat tcgttgaaca gttgccaggc acagaagaaa ttcagtcccg
    11701 tgccaaaacc ggtttcaccg atcaccaggc actgttccgg cgccatcgtg ctgaaacgct
    11761 ggcgcaggtc gttctggtca atgaacacat gacgggtttc ctccaggctc tggtccttgg
    11821 agaaataaat gtcatcgaac tggcgcgaat gggggcggcc ctgctcgtcc cagtcgatct
    11881 gggcgtattg ggttacttca gtcatggtcg gctcaggtca ggctagaacg gcattttagc
    11941 tgatcgacac gacactgttg gcctgacctg gagcaatctt tgtttgccgg acaaagaggg
    12001 cctcgatccg ctagtcttgc ttatccatgt agggagcctg gtatgttcga atccgctgaa
    12061 attggtcacg caatcgataa agagacctac gacgccgaag tgcccgcact tcgcgaagcg
    12121 ttgttggagg cacagttcga actcaaacag caggcgcgtt tcccggtgat tgtgttgatc
    12181 aacggtattg aaggcgctgg caagggcgaa acggtgaagc tgctcaacga gtggatggac
    12241 ccgcgcctga ttgaagtgcg tacgttcgac caacagactg acgaagaact ggcgcggcca
    12301 ccggcctggc gctattggcg cgcattgccc gccaaggggc gaatgggtgt gtttttcggc
    12361 aactggtaca gccagatgct gcaggggcgg gtccacgggc atttcaagga tgccgtgctc
    12421 gaccaggcca tccgcggcgc cgagcgcctg gaggaaatgc tctgtgacga aggggcgttg
    12481 atcttcaagt tctggtttca cttgtcgaaa aaacagatga aggcgcggct caaggcgctc
    12541 aaggacgatc cgttgcacag ctggcgcatc agcccgctgg attggcagca gtcgcaaacc
    12601 tatgatcgct ttgtgcgttt cggtgaacgg gtgctgcgcc agaccagccg agattacgcg
    12661 ccctggcatg tcattgaagg tgttgacccg cattaccgca gcctggcagt cgggcgcatt
    12721 ctgcttgaag gcttgcaggc cgcactcaag gtccagcatg caccgattca tcgcgcccac
    12781 gtcgccccgc tgggcgagag tatcgatgag cgcagcttgc tgggtagcct ggacatgacc
    12841 ctgcgtctgg acaaaagcga gtaccaggag cagttgatca ctgaacaagc gcggctggcg
    12901 ggtttgctgc gcgacaagca tatgcgtcgc cacgccctgg tggcggtgtt cgagggcaat
    12961 gatgcagcgg gcaagggcgg cgccattcgt cgcgtcgccg cggcactgga cccacggcag
    13021 taccgtatcg tgccgattgc tgcgccatcc gaagaggaac gcgcacaacc ttacctgtgg
    13081 cggttctggc gccatgtgcc ggcacgcggc aaattcaccg tgttcgaccg ctcctggtac
    13141 ggccgcgtgt tggtcgagcg catcgaaggc ttctgcagcc aggccgactg gatgcgtgcc
    13201 tacggcgaaa tcaacgactt tgaagagcaa ctgaccgatg ccggtgtagt gctggtcaag
    13261 ttctggctgt cgattgacga acagacccag ctcgagcgtt tccaggagcg tgaaaagatt
    13321 ccgttcaagc gtttcaaaat caccgaggaa gactggcgca atcgcgaaaa gtgggggcaa
    13381 tacgcggaag ctgtcggcga catggtagac cgcaccagta ccgaaatcgc gccatggaca
    13441 ttggttgaag ccaatgacaa gcgctgggcg cgggttaaag tgttgcgcac catcaacaat
    13501 gccctggagg cagcgttcaa aaaagacaag aaatagcagt cgctcgggga atgaagtgct
    13561 gaaatctttt ctgcaattgt acctgtcggc ccccacagcc aatccgtaga attcaggctt
    13621 ccgccacaca gggctattga ggctgttatg cacatttctt ccggacgctg ggtctacggt
    13681 ctgtcacttt cactgctgac cgccttgctc tggggcatcc tgccgatcaa gctcaaacaa
    13741 gtgttgcagg tgatggaccc ggtcactgtc acctggtttc gcctgttggt gtccggcggc
    13801 ctgttgtttg cctggctggc ggccagcaag cgtctgccgt cgttcaatcg tcttgggcgc
    13861 aaaggctggg ggctggtagc gctggccacg ggtggcctgg tcggcaacta cgtgctgtac
    13921 ctgatggggc tcaacctgct cagccccggc accgcgcagt tggtggtaca gcttgggccg
    13981 gtgctgttgc tggtggccag tgtgatcttg ttcaaggaac gcttcagcct cgggcagggt
    14041 gtgggcctgt tgattctact gatggggttt ggcctgttct tcaaccaacg cctggaagag
    14101 ctgctgactt ccctgagtgt ctacaccacc ggtgtactga ctattatcct ggctaccacc
    14161 atttgggtgt tctacgccct gagtcagaag caattgttga cggtgtggaa ttcgatgcag
    14221 gtgatgatgg tcatctacct gtgctgcgcg gtgctcctca cgccgtgggt gcatccgcta
    14281 gaagccttgc aactgaaccc gctgcaaggc tggttattgc tcgcctgctg cttgaatacc
    14341 ttggttgcct atggcgcttt cgccgaagcg cttgcacact gggaagcgtc caaggtcagt
    14401 gccaccctgg cgctgacgcc gctggtgacg tttgtcgccg tggcgctggc ggcctggttc
    14461 tggcctgact atgtgcacgc cgagcagatc aacacgctgg gatatatcgg tgcaatggtg
    14521 gtggtagtgg gctcggtgct gaccgcgttg gggccttcgc tgcttgccgg ctggcgggcc
    14581 aggcgggtgc gcctggcccg ctgactcagc cttttttacc cggttcgagc atgtcttgtg
    14641 ggcgtaccca ctgat
//
