LOCUS c00045_3300012.. 24618 bp DNA linear UNK 01-JAN-1980 DEFINITION 3300012805.a:Ga0160464_100417. ACCESSION c00045_3300012.. VERSION c00045_3300012.. KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 5.1.0 Run date :: 2019-11-23 06:59:42 Original ID :: 3300012805.a:Ga0160464_100417 NOTE: This is a single cluster extracted from a larger record! Orig. start :: 8282 Orig. end :: 32900 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..24618 /aStool="rule-based-clusters" /contig_edge="True" /core_location="[28282:30547](+)" /cutoff="45000" /detection_rule="cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)" /neighbourhood="20000" /product="transAT-PKS-like" /protocluster_number="1" /tool="antismash" proto_core 20001..22265 /aStool="rule-based-clusters" /tool="antismash" /cutoff="45000" /detection_rule="cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)" /neighbourhood="20000" /product="transAT-PKS-like" /protocluster_number="1" cand_cluster 1..24618 /SMILES="" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)" /detection_rules="(cds(Condensation and (AMP-binding or A-OX)) or (Condensation and AMP-binding))" /kind="interleaved" /product="transAT-PKS-like" /product="NRPS" /protoclusters="1" /protoclusters="2" /tool="antismash" region 1..24618 /candidate_cluster_numbers="1" /contig_edge="True" /product="transAT-PKS-like" /product="NRPS" /region_number="1" /rules="cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)" /rules="(cds(Condensation and (AMP-binding or A-OX)) or (Condensation and AMP-binding))" /tool="antismash" CDS 308..2254 /locus_tag="ctg45_10" /transl_table=11 /translation="MDKWLGHPTSLKIISVIIGLLLWAVVHFDTDSPNNVASLLETRDI PVKVTAEGLDDSLYELRLLEPDNVRLTVRGNRAVLMAASPDDYKVYVDLTDVREGEHIL QLNYDLPGRVQFIELSPSRVTVELVPLQTSEYEIQINTTGKPAYDYRADTPIIKPGNRA FVTLPDDQLELVGSVGATLDIEGEENSVTEKRVELKAYDKNGEEMPNAVINPATVEVEV PIVKPYKLLPLQIGQAGSLPEGVSLLSLTPEVNEVTVYGPQAELDKLTYYDDVVVNLGG IQQSGKITVELDPPPGTAGISPQSLDIAVEIAASDTRTVPEVPIRLSGLADGLEAKIVE PASQRVDIQVTGAPGVLAELGAGDIQLIADLNGQVPGTHEIPLEIQLPRYVREASGEAL TVSVEITAVEEAIAPESEEPGEEGTPGSGQEEPLPPDDEPTDNPDDTTGTGTPGTPGTG GEGGGDTGNPDEPGGEQGSGTGGIRQEQENPPPDGGNGTVESEETGTTPVPGESGEVDP GTEGVGGIAEPVPPASEEDSGSIGKPVFLPGLVGTGSPAIGSSGYGGSGIPVVSDSERE PQPTPITRAWSDKLAYGMFTAGVAAAAAAAAVLWGRVMSSHAPIRGFWRLWSRRSGRRV AATTGLLGTHRRS" protocluster 2265..24618 /aStool="rule-based-clusters" /contig_edge="True" /core_location="[30546:32898](+)" /cutoff="20000" /detection_rule="(cds(Condensation and (AMP-binding or A-OX)) or (Condensation and AMP-binding))" /neighbourhood="20000" /product="NRPS" /protocluster_number="2" /tool="antismash" proto_core 22265..24616 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(cds(Condensation and (AMP-binding or A-OX)) or (Condensation and AMP-binding))" /neighbourhood="20000" /product="NRPS" /protocluster_number="2" CDS 2311..3651 /locus_tag="ctg45_11" /transl_table=11 /translation="MGKYFGTDGVRGVANRELTPELAYKIGRCGGYVLAGEADKPKVVI GLDTRISGPMLEAALVSGLLSIGASVVKLGVVSTPAVAYLTRQLGAAAGVMISASHNPV EDNGIKFFGGDGFKLSDDTELEIERLMDGVTDALPRPEGGELGTVTVLEDAQERYLSFL KTTIGHRFDGLKIVLDCAHGAAYQLAPAVFRDLGAEIVTVGAEPDGLNINDGVGSTHPE YVREQVLAHGADLGLSFDGDADRLIAIDDTGAEIDGDFLLCICGDAMKRAGKLNSDTVV TTVMSNIGFFKAAEALGLKTAQTAVGDRYVMEEMRRGGFNLGGEQSGHMIFLDYNTTGD GILTALQLVDTLVESGKKLSELKTLMSKYPQVLVNVRVADKSLFQGNVAIDEAVARVEQ ALGDNGRVLVRASGTESLIRVMAEGPDKAEIERYVEEIVDVVKAQLG" CDS 4122..4298 /locus_tag="ctg45_12" /transl_table=11 /translation="MRLMEAIIQQAICDGYPALSLSVDPHNRAAVRLYERLGFSYCGTS GTSWTMKLDLDNS" CDS 4503..4733 /locus_tag="ctg45_13" /transl_table=11 /translation="MVRRGPPGSGILPISCSFKTTRATGRTKAQRNVCFSMLLEVVHIF SLSFPHVHDADVTSVRSEGFFKYRHHVCTSS" CDS 4894..6726 /gene_functions="biosynthetic-additional (rule-based-clusters) GATase_7" /gene_kind="biosynthetic-additional" /locus_tag="ctg45_14" /sec_met_domain="GATase_7 (E-value: 1.4e-18, bitscore: 58.2, seeds: 307, tool: rule-based-clusters)" /transl_table=11 /translation="MCGIVGYIGKRDTQEILLEGLKKLEYRGYDSAGIAVFTSGGLTVS KSKGRLAILEEKLQGAPLHGSAGIGHTRWATHGKPSDMNSHPHTDTTTKFSVVHNGIIE NYLELKEELSLSGVQFVSETDTEVISHLIASVYEGDIVQAVQRAVKRMRGAFALGVLTE HEPDRLVAVRYASPLVIGLGEGENFIGSDIPAILEHTRNVYILDDGEMAVLTRDGVELL TTEGEIISKEIFHVDWDLMTAEKAGFDHFMLKEIYEQPKAYRDTMRGRISDDGRKIVLP EIGMTPEQIKAITKIHIVACGTAYHAGLVGKSVIESLARIPVETDVASEYRYRNPIITP ETLVIVVSQSGETADTLAALREAKRCGARVLAITNVVGSSVSREADDVITTWAGPEIAV ASTKAYTSQLIAFYLVGLYLAQNVGTRDADWIGSVTAELQQLPEQVESILAQSTALKQI AETLARHSSLFFIGRGLDFAIAQEGSLKLKEISYIHSEAYAAGELKHGTLALIEEGTPV IALVTQEELAEKTISNIKEVKARGAHVLGVTNESNQHEVAKSVDEVFAIPNTLHLLTPA LSVIPLQLLSYYASLALGHDVDKPRNLAKSVTVE" CDS complement(6788..7843) /gene_functions="resistance (resist) vanS (Score: 237.9; E-value: 1.1e-72)" /gene_functions="regulatory (smcogs) SMCOG1003:sensor histidine kinase (Score: 184; E-value: 1e-55)" /gene_kind="regulatory" /locus_tag="ctg45_15" /transl_table=11 /translation="LTRKKDRPKKIQVNFMLNAVYSFFIAFILTILVIYVLDYFHFPGF HGLTLALLIGFFVASFFLLTRRIVTDFVTLEWGLQIIAEGDLDYRVPVERRDELGRVAT NINLMAERLQEQIVRERELEKSKMEMISGVSHDLRTPLTSIIGYIELLRANAFQSKEEY NRFIDNTLNKAVHLKRMLDDLFEYTQLTSNEARLKLSSFDLSKLVGQLLFEFEPIALEN NISLLTKLGEKPMMIVADSDKIARAIDNLLMNALKYSTKPGTVEIHVTSNHRQVTLMIE NKGQPLTKEQEQKIFERFYKADHSRSSEDIQIGAGLGLSITKNIVQLHGGDILLEHMDG HYKFSLVLPLA" CDS complement(7836..8516) /gene_functions="resistance (resist) vanR (Score: 285.7; E-value: 1.6e-87)" /gene_functions="regulatory (smcogs) SMCOG1008:response regulator (Score: 220.7; E-value: 2.9e-67)" /gene_kind="regulatory" /locus_tag="ctg45_16" /transl_table=11 /translation="MNTVLVVDDDSEIRDIIHVYLRNEGYQVVEAANGLEALKTIELVD VQLVILDVMMPKMDGIHACFKIREKSDVPIIMLSAKQEDIDKITGLTSGADDYMVKPFN PLELLARVKAQFRRNALQGKVNERAILHIRDLAIDRNKHAVTLRGKDISLTPLEFGILE LLATHQAQVFSTEKIYESVWKEPFGDSDNTVMVHVRNLREKIEDNPRAPQYIKTVWGVG YKVD" CDS complement(8542..9147) /locus_tag="ctg45_17" /transl_table=11 /translation="LNEIDLEWNSKDEVDNLSKNVYGQFIRSFLRQPRQVGSVIPSSQH LSTRMTNAVAWHEVSAVAELGSGTGAITRVLKQHTTENMHVLLFEMDEAMRSNLKQDYP DFQVHANACQLTDALSRAGLNALDCIISGLPFFNFPPALKMKLLDQVHQALRPGGQFIA FQYSLQMKKLLSEKFILEEIGFVPLNFPPAFVYVCRKK" CDS complement(9144..9620) /gene_functions="other (smcogs) SMCOG1188:hypothetical protein (Score: 95.6; E-value: 3.4e-29)" /gene_kind="other" /locus_tag="ctg45_18" /transl_table=11 /translation="MINDTILNLIDAYGYFLFFLAFCLGPFGIPVPNEVTIVTGSILSV NGILNPFLTYVSILSGLLIAVTISYTTGRIFGGYFGSKLQENRHFLKTRLLLHKHGKWA ICIGFFIPVVRYLMPLLVGLSRVNARTFIVLSYSSAIFWTAAFFGAGSIAGNYF" CDS complement(9617..9835) /locus_tag="ctg45_19" /transl_table=11 /translation="LSVCKWVHKTDAAVSHLHYARALPHAPTLNPSVSIIILQYILVFR NSSEKSPVESQKFLLIFLYQIEIRRYR" CDS complement(9887..10252) /locus_tag="ctg45_20" /transl_table=11 /translation="LMMLNHDDVHLISREINLILNSEDNVTMSGATPLGMSFLLELELD VFSGFDEEEAYLGNKRFEEFLVVLYLTGHIAFDNDHLIDPLRKKFKDGYLLRYFGVQDG NDKCLVDERLKEPQEDA" CDS 10253..10654 /locus_tag="ctg45_21" /transl_table=11 /translation="LRNSFLIPKDIGCDRCFKLGIGVILQARKLIHIHLLCFIFCDQIV MNILQCKRIGYFAFKEFLIKLLQVNHERSDTPISTILALSYHSRRQSCSSFDAVSMARS SPWSLASRCSAASIPAVTPAEVISLPLST" CDS complement(10507..11073) /locus_tag="ctg45_22" /transl_table=11 /translation="VYEHVDALDVTGPFDVFAVGSNWGQDFHVYTVALESTEPIRTISG LTIVPQFASSECPQPDILIVPGGWGSRKEMHNERLTRWIRETSERAAFTLSVCTGSLLL AKAGLLEGMRATTNRRAMDLLLGAAHPSTTVVEHVRYVDNGKLITSAGVTAGIDAALHL LAKLHGEERAIDTASKLEHDWRREW" CDS 11617..11955 /gene_functions="regulatory (smcogs) SMCOG1287:AraC family transcriptional regulator (Score: 58; E-value: 1.4e-17)" /gene_kind="regulatory" /locus_tag="ctg45_23" /transl_table=11 /translation="MQNQIEIVVNYIEDHVKDPFDCDRLAEIDACSKSHFFKQFTLLTG YTPMNYVLRRKLQFASKQLITGKEKIIDVAFEFGFESHDVFSRAFKIEHGVLDYYTTLQ FFERVEKR" CDS 11978..12562 /locus_tag="ctg45_24" /transl_table=11 /translation="MKRYTIHYIPQPNFYACDQACLAMAAGITIEEAMIMMGDKRGVGS SVLYKALKKCNIGYTSWRRFSSMEELPPLCILGVKFPDYSHSVLFYNGVFYDPEYGVMT HYTPNGEIEHYIELFIDDAYEGLDPTVKLPEDYQSAFEHDPEAFELFHQLSYPEKSKLI NKISHYKDPKIRKANISKSIHQLKMRKHDIE" CDS complement(12677..15724) /gene_functions="transport (smcogs) SMCOG1049:AcrB/AcrD/AcrF family protein (Score: 686.6; E-value: 9e-208)" /gene_kind="transport" /locus_tag="ctg45_25" /transl_table=11 /translation="MIWFTKWSFRNKSAVFITSALILILGIVSYRLLPMELLPYSDNPN ISVIVIGQGYDADTLNQSVTQPMEKALIGIRGKKETFSESGSGYVKMDLMFDSDTDMRQ AKTDVQEALQAVELPPNTSKPYITLLNTAMISIANVSVTFPDGITKHNLSLVEEQILPE FQSIEGVSSVTTYGKIDQPITVELDQAAMERSNIPVTAVLTALQGQNAGLAVGSSLVDN KNSSITVIGHIEGLDELKRLPVSGDVQLSELASVEYKSTEGNLTRINGEDAVIMIITKE AQANAVSLSEMVREKAVELDEQFVDARIGVYFSTGDMVKTSVNSMLLEVLVGAFFATLV ILFFLRNLKTTVITVVSIPMSLGLTLFLLYQSGITLNILTLGGVAVSVGRLVDDSIVVV ENIYRRMQKDGVTSHIVDATKEVTAAITSSTLTTVAVFLPIGLVGGGLQSFLLPIALTV TYSLLSSLLVALTVVPLLSARMLRNAKMPKHKAPKRYVSLLKWSLNTKWLVLTMTLLLF ATSVGLYLSTPQGIIDNSEAEFVMASLEYPTETSPALVAEKAMELEKQLIQQDDIDFIY TQMGNSSGGAEWGLVGSPTIANLTLKMKKDVNAEPVIQAIEAQKSNYPEATLTVGSGTM TGSSNAAITIDVVGANSDPDTLSELANQILQSIEGIEGVTEASSNEQDKQQISSLIVDP ARANTQEVAQQLSILFNRIPLGTVTENDRPTPVYLEPLMPSATTAELNQLMIQTSQGVV PASSIGEWKNELKTGRILEKDGKSYLRVIATIEPSMVSLVSADIQKAIFGSGSQPGLNI EDGIDVIIGGASSQQANDFSDIFLTMLVSIGVVYLILVVTFKSVRTPLVILCTLPLAAI GAILGIIVSGASVDVTSLLGGLLLIGIVVTNAIVLIDKIKQNEQTMMIREAITEAAAIR LRPILMTAMATILAMMPLLFRTSESGSLVSSGLATVVISGLLVATLMTLFVVPVIYELF YFRKSKHQIRTGSHAKSTSSAGQIEM" CDS complement(15917..16624) /locus_tag="ctg45_26" /transl_table=11 /translation="LLLRLLITDYRSAGPFLLLIGLVLPLGFMWILKQYVGTGPDATWM LAGNIVMAISFGSVSFAIQRTALMKVEGELDYYGSLSVHKSSFLAALFTESIVFALPAM LSSMLFGHLLLDIPLLDLASGVPIALLAAASMTIVGSTIGSYAKTMVHFAIYSYLPYLA VTFFSPVLLPIEKLPVFLQFTSYLLPTGQAALALNEIFEHSYGLRLWSLVAALCLWLIF AVALALKKLDWRT" CDS 16953..17555 /locus_tag="ctg45_27" /transl_table=11 /translation="MSLQLLRRAYSEYFPFAHNSDTVQRVLGLDDIMGHEDDGPALLRG LLDSFPDRSPDLGIEIVGRFIENNDGTPPNDRNGYSDKTSKAAGQDLDFLAEMRRKTEF MNQRLGILFGLCGGDASQSSGHLEQLERHRLRWKPDVLRLKRDKAACFPRIPDHIDVKQ TYRTACWFDHACQLADKRALAGAVRTEQAEHLALLYG" CDS complement(17669..18070) /locus_tag="ctg45_28" /transl_table=11 /translation="LAGKHSLEEQQRRWIYSVIHCFDHKDTVLFGRLVMQILGAPDVHP PACVEALNRFTKLEIQILCSLLVDAGKSLEEATAQSCLVFNTILGNKLIGMHQDAFNIL FRTGCDLLGVSDQPLPDPIDYPSFPWTLE" CDS 18155..18304 /locus_tag="ctg45_29" /transl_table=11 /translation="MYQTVAYSCFGGNIRNLGAKVTGRCKGMKRSAENASALKIGRACS CSSG" CDS 18463..18621 /locus_tag="ctg45_30" /transl_table=11 /translation="LVDFFIDNIVDSTSDPFSVSIFNSLIDKVINCFYDACPSVELNVD VFFVIFR" CDS complement(18990..19430) /locus_tag="ctg45_31" /transl_table=11 /translation="LLAQLQLGVIILSNTNKYADAASCPASRHFLCVFYSLPRGLQQQA LLRVHPRGFSGRNLEEGGIELVDVAYKPAFLHPLFLNSIPALARHIRNRDAAFLQQLPV GVEIWRSRESTAHAYYRYRLRHIVLTCGGLSSSYCIANQVIH" CDS 20001..22265 /NRPS_PKS="Domain: Trans-AT_docking (125-283). E-value: 3.9e-21. Score: 67.7. Matches aSDomain: nrpspksdomains_ctg45_32_Trans-AT_docking.1" /NRPS_PKS="Domain: oMT (315-571). E-value: 6e-62. Score: 201.0. Matches aSDomain: nrpspksdomains_ctg45_32_oMT.1" /NRPS_PKS="Domain: PP-binding (632-694). E-value: 4.3e-16. Score: 51.0. Matches aSDomain: nrpspksdomains_ctg45_32_PP-binding.1" /NRPS_PKS="type: other" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS-like: hyb_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS-like: tra_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS-like: itr_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS-like: ATd" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS-like: ene_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS-like: mod_KS" /gene_functions="biosynthetic (rule-based-clusters) transAT-PKS-like: PKS_KS" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1089:methyltransferase (Score: 73.4; E-value: 3.4e-22)" /gene_kind="biosynthetic" /locus_tag="ctg45_32" /sec_met_domain="PP-binding (E-value: 2.8e-16, bitscore: 51.0, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="PKS_KS (E-value: 6e-37, bitscore: 118.6, seeds: 2284, tool: rule-based-clusters)" /sec_met_domain="ATd (E-value: 2.5e-21, bitscore: 67.7, seeds: 19, tool: rule-based-clusters)" /sec_met_domain="ene_KS (E-value: 7.1e-22, bitscore: 68.6, seeds: 19, tool: rule-based-clusters)" /sec_met_domain="mod_KS (E-value: 9.9e-33, bitscore: 104.6, seeds: 217, tool: rule-based-clusters)" /sec_met_domain="hyb_KS (E-value: 3e-38, bitscore: 122.8, seeds: 33, tool: rule-based-clusters)" /sec_met_domain="itr_KS (E-value: 1.1e-29, bitscore: 94.6, seeds: 96, tool: rule-based-clusters)" /sec_met_domain="tra_KS (E-value: 6.3e-35, bitscore: 111.9, seeds: 44, tool: rule-based-clusters)" /transl_table=11 /translation="LGEQRGAERKCSIGAVKANIGHLEAAAGIAGLIKTALMLKHSWLV PTANYKTANPYIPMDRLAVSIQQQSEPWNCPEEEKRIAGISSFGFGGTNCHLVLEQAPE APASLSAEQHQQPEQPERMHYMLLSARSEASLRAMARLAVSALTRAEANPSLTDLCYTL CARHSHHDHRIAVIGHAAADIAASLHRYINNEPSSMVYLAGEEQSSADIEAEIRHVCRS EDGLRIANLAERTIAGTDHNTRAEVIAKLYILGCELDWESLYPEGRAVNIPPYPWDRKR YWFKAAGGEAELPGEAEAETELEAYYESLAQDLTAHEQYLSFAPFAQADPSFSWVLALS EPSRYPDSYAAMSAAQAEMRRVMFRHVKWDAVKRMMEIGCGYGSDLIKLAQSQPHLSLT GYNISDAQIAIARERVSALSLENRIQFFKRDVQQDALSKQYECALAVQILHHLPDKRKA LGTMASHLAAGGLIVMAEMMSNTSERLEHPQSSAYYDTKEEWANLLAEHQLQVLDCIDA SREVGNFLDDPQFYDNVLQLQRNRSETVRNHLEGPHLLGGLLRRKVVTYGLITVQKTSC LHTDSLRKLNLERLNHAIPYPVAAGWSGETAHTTDISSTERRTVLKPDDQAGYERMLRD AAAEVLEIDPERLDINRSLDSLGLDSIMAIDLKQKIERQLELALPVTELLQGPSIRQLA IKLTEAAFEETAAADTVMSLEDKASGATSPEQLLASLDNLPKEELERLKAIYLQDRGEQ K" CDS_motif 20040..20084 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg45_32_0001" /evalue="4.50E-04" /label="PKSI-KS_m6" /locus_tag="ctg45_32" /protein_end="28" /protein_start="13" /score="12.6" /tool="antismash" /translation="GAVKANIGHLEAAAGI" aSDomain 20376..20849 /aSDomain="Trans-AT_docking" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg45_32_Trans-AT_docking.1" /evalue="3.90E-21" /label="ctg45_32_Trans-AT_docking.1" /locus_tag="ctg45_32" /protein_end="283" /protein_start="125" /score="67.7" /tool="antismash" /translation="MLLSARSEASLRAMARLAVSALTRAEANPSLTDLCYTLCARHSHH DHRIAVIGHAAADIAASLHRYINNEPSSMVYLAGEEQSSADIEAEIRHVCRSEDGLRIA NLAERTIAGTDHNTRAEVIAKLYILGCELDWESLYPEGRAVNIPPYPWDRKRYWF" aSModule 20376..22082 /domains="nrpspksdomains_ctg45_32_Trans-AT_docking.1" /domains="nrpspksdomains_ctg45_32_oMT.1" /domains="nrpspksdomains_ctg45_32_PP-binding.1" /incomplete /locus_tags="ctg45_32" /tool="antismash" /type="unknown" aSDomain 20946..21713 /aSDomain="MT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg45_32_oMT.1" /domain_subtype="oMT" /evalue="6.00E-62" /label="ctg45_32_oMT.1" /locus_tag="ctg45_32" /protein_end="571" /protein_start="315" /score="201.0" /tool="antismash" /translation="AHEQYLSFAPFAQADPSFSWVLALSEPSRYPDSYAAMSAAQAEMR RVMFRHVKWDAVKRMMEIGCGYGSDLIKLAQSQPHLSLTGYNISDAQIAIARERVSALS LENRIQFFKRDVQQDALSKQYECALAVQILHHLPDKRKALGTMASHLAAGGLIVMAEMM SNTSERLEHPQSSAYYDTKEEWANLLAEHQLQVLDCIDASREVGNFLDDPQFYDNVLQL QRNRSETVRNHLEGPHLLGGLLRRKVVTYGLITVQ" aSDomain 21897..22082 /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg45_32_PP-binding.1" /evalue="4.30E-16" /label="ctg45_32_PP-binding.1" /locus_tag="ctg45_32" /protein_end="694" /protein_start="632" /score="51.0" /tool="antismash" /translation="LRDAAAEVLEIDPERLDINRSLDSLGLDSIMAIDLKQKIERQLEL ALPVTELLQGPSIRQLAI" CDS 22265..24616 /NRPS_PKS="Domain: Condensation_LCL (34-325). E-value: 3.5e-84. Score: 274.1. Matches aSDomain: nrpspksdomains_ctg45_33_Condensation_LCL.1" /NRPS_PKS="Domain: AMP-binding (502-783). E-value: 1.3e-63. Score: 206.7. Matches aSDomain: nrpspksdomains_ctg45_33_AMP-binding.1" /NRPS_PKS="type: NRPS" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 360.1; E-value: 3.4e-109)" /gene_kind="biosynthetic" /locus_tag="ctg45_33" /sec_met_domain="Condensation (E-value: 5.6e-69, bitscore: 223.5, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 1.6e-59, bitscore: 192.5, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MEKPLQSGEHQEADDERLQLARMMWKAARGELETGPLSYGQQAMW FIHQMEPLDAAYNTHFAARIVAGIDVAAMRQAFQGLVDRHGVLRTSYRLQGDVPEQRVE AAAEVAFREVQAVGWTEERLRAVLIEETRRPFDLTTGPVMRVHLYHLPFDQAVLLVTIH HIAIDYWSLAVLLDDFRRLYTGQPLPALAAGYDKFVRWQREFISSPRGVQSGDYWHDRL SGELPLLQFVKTASAAPPLADAHSSGTFIFQLDRHLAERLKLLGQSLGATLFTVLLAAF NVMLGRYTHQDDIVVGTPTAGRNRPEFEAVVGYLVNAVVIRTAIPALQPFAEYVRQVRQ DVLEAMEHQDYPFPLVVQELQPLRHLKRTPLIRAMFAFQKAPRLEEQGLTSFILGAPGS KLQFGDMELRPLDLPQQEGQFDLTLHLDATSLAGAIQYDTALFDRDAIERMASHYETLL AGIAADPNCRIGELPMLTPGELAELERWNATAAPYERTACIHQLFERQVARAPQAEAIR CGETRISYRSLNERANRLAHYMQAEGIGAGSRVGICLPRTPELIVVALAALKAGAAYVP LDPSHPAERLGDVLTDAGASLVLTDERHAERLTEGLAAVQGRRADSAGAGADTSDQERV LGQVQGADSGPTREAGCSQPCEAPEPIRLLCIDREAKAIAAAPSSAPVCAADPDAAERL AYIIYTSGSTGKPKGVMVQHRPVINLITWANTSFGMSERDRVLWVTSLGFDLSVYDLFG VLAAGGSICIADEQEVRDPERLLTLLEREEI" aSDomain 22367..23239 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg45_33_Condensation_LCL.1" /domain_subtype="Condensation_LCL" /evalue="3.50E-84" /label="ctg45_33_Condensation_LCL.1" /locus_tag="ctg45_33" /protein_end="325" /protein_start="34" /score="274.1" /tool="antismash" /translation="GPLSYGQQAMWFIHQMEPLDAAYNTHFAARIVAGIDVAAMRQAFQ GLVDRHGVLRTSYRLQGDVPEQRVEAAAEVAFREVQAVGWTEERLRAVLIEETRRPFDL TTGPVMRVHLYHLPFDQAVLLVTIHHIAIDYWSLAVLLDDFRRLYTGQPLPALAAGYDK FVRWQREFISSPRGVQSGDYWHDRLSGELPLLQFVKTASAAPPLADAHSSGTFIFQLDR HLAERLKLLGQSLGATLFTVLLAAFNVMLGRYTHQDDIVVGTPTAGRNRPEFEAVVGYL VNAVVIRTAIP" aSModule 22367..24613 /domains="nrpspksdomains_ctg45_33_Condensation_LCL.1" /domains="nrpspksdomains_ctg45_33_AMP-binding.1" /incomplete /locus_tags="ctg45_33" /tool="antismash" /type="nrps" CDS_motif 22427..22543 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg45_33_0001" /evalue="6.40E-14" /label="C2_LCL_024-062" /locus_tag="ctg45_33" /protein_end="93" /protein_start="54" /score="44.3" /tool="antismash" /translation="AAYNTHFAARIVAGIDVAAMRQAFQGLVDRHGVLRTSYRL" CDS_motif 22748..22813 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg45_33_0002" /evalue="2.60E-08" /label="C3_LCL_132-143" /locus_tag="ctg45_33" /protein_end="183" /protein_start="161" /score="26.4" /tool="antismash" /translation="IHHIAIDYWSLAVLLDDFRRLYT" CDS_motif 23141..23230 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg45_33_0003" /evalue="2.00E-14" /label="C5_LCL_267-296" /locus_tag="ctg45_33" /protein_end="322" /protein_start="292" /score="45.9" /tool="antismash" /translation="DIVVGTPTAGRNRPEFEAVVGYLVNAVVIRT" CDS_motif 23279..23398 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg45_33_0004" /evalue="3.40E-16" /label="C67_LCL_14fromHMM" /locus_tag="ctg45_33" /protein_end="378" /protein_start="338" /score="51.6" /tool="antismash" /translation="RQDVLEAMEHQDYPFPLVVQELQPLRHLKRTPLIRAMFAFQ" aSDomain 23771..24613 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg45_33_AMP-binding.1" /evalue="1.30E-63" /label="ctg45_33_AMP-binding.1" /locus_tag="ctg45_33" /protein_end="783" /protein_start="502" /score="206.7" /specificity="consensus: X" /tool="antismash" /translation="FERQVARAPQAEAIRCGETRISYRSLNERANRLAHYMQAEGIGAG SRVGICLPRTPELIVVALAALKAGAAYVPLDPSHPAERLGDVLTDAGASLVLTDERHAE RLTEGLAAVQGRRADSAGAGADTSDQERVLGQVQGADSGPTREAGCSQPCEAPEPIRLL CIDREAKAIAAAPSSAPVCAADPDAAERLAYIIYTSGSTGKPKGVMVQHRPVINLITWA NTSFGMSERDRVLWVTSLGFDLSVYDLFGVLAAGGSICIADEQEVRDPERLLTLLEREE I" CDS_motif 23957..23998 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg45_33_0005" /evalue="8.70E-06" /label="NRPS-A_a2" /locus_tag="ctg45_33" /protein_end="578" /protein_start="564" /score="18.8" /tool="antismash" /translation="LAALKAGAAYVPLDP" CDS_motif 24347..24406 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg45_33_0006" /evalue="1.20E-11" /label="NRPS-A_a3" /locus_tag="ctg45_33" /protein_end="714" /protein_start="694" /score="36.2" /tool="antismash" /translation="AYIIYTSGSTGKPKGVMVQHR" CDS_motif 24518..24547 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg45_33_0007" /evalue="2.10E+01" /label="NRPS-A_a2" /locus_tag="ctg45_33" /protein_end="761" /protein_start="751" /score="-0.3" /tool="antismash" /translation="FGVLAAGGSIC" ORIGIN 1 atcatccgag gcaaccagat catggctgcg gcctgttatc tgccgctctc ggagaacccg 61 ttcatcagca aggagctggg gacgcgtcat cgcgccggta tcggcgtcac cgaggtgagc 121 gacgcgatct ctgtcatcgt ctccgaggag acgggacagg tgtcgctggc gatcggcggc 181 atgatcgtcc gcgatatcaa ggaagagtcg ctgatcgcca agctgttcga cgagctgcgc 241 ccggaggcat cgacgcgcga gaagacgaag gccaaggttt ccttctggaa gagaaagggg 301 gattccaatg gataagtggc tgggacaccc tacctcgctg aagattatct cggttatcat 361 cggactgctg ctgtgggcgg tcgtgcattt cgacaccgac tcgcccaaca atgtcgcttc 421 gctgctggag acgcgggata tccccgtcaa ggtcacggcc gaggggctgg atgactcgct 481 gtatgagctg cggctgctgg agccggacaa tgtccgtctg acggtgcggg gcaatcgcgc 541 cgtcctgatg gcagcttcgc cggacgacta caaggtgtac gtcgatctga ctgatgtccg 601 agagggcgag cacatcctgc aattaaatta cgatctgccg ggacgcgtcc agttcatcga 661 gctgtcgcct tcgcgggtga cggtggagct ggtgccgctg cagacgagcg aatacgagat 721 tcagatcaat acgacaggca agcctgccta tgattatcgg gccgacacgc cgatcatcaa 781 gccaggcaac cgcgccttcg tgacgctgcc ggacgaccag ctcgagctgg tcggctcggt 841 cggcgcgacg ctcgacatcg agggcgaaga gaatagcgta acggagaagc gagtcgagct 901 gaaggcttat gacaagaacg gcgaggagat gcccaacgcg gtcatcaatc cggcgacggt 961 cgaggtcgag gtgccgatcg tcaagcctta caagctgctg ccgctccaga tcggtcaggc 1021 gggcagtctg ccggagggcg tcagtctgct ctcgctcacc cctgaggtca acgaggtgac 1081 ggtgtacggg ccgcaggccg agctggacaa gctgacctac tacgacgatg ttgtggtgaa 1141 cctgggcggc atccagcagt ccggcaagat cacagtcgag ctcgatccgc ctccgggcac 1201 agcgggcatc agcccgcaaa gtctggatat cgcggtcgag atcgcggcgt cggatactcg 1261 gacggtaccg gaggtgccga tccggctgag cggtctggcg gacggtctgg aggccaagat 1321 cgtcgagccg gcgagccagc gggtcgatat ccaggtgacg ggcgcgccgg gcgtgctggc 1381 cgagctgggc gcgggcgaca tccagttgat cgccgatctg aacggacagg taccgggtac 1441 gcatgagatt ccactggaaa tccagctccc gcgctacgtg cgcgaggcga gcggcgaggc 1501 gctgacggtg agcgtggaga ttacggcggt cgaggaggct atcgccccgg agtctgagga 1561 gcctggtgag gaggggacgc cagggtccgg tcaagaggag cccctcccgc cggacgacga 1621 gccgacggac aaccctgacg acacgacggg gacgggtacg cccggtacgc caggtactgg 1681 cggcgagggc ggcggcgaca ccggcaatcc tgacgagccg ggaggcgagc aaggcagcgg 1741 caccggcggc atccgtcagg agcaggagaa tccgcctcca gacggcggca acggaacggt 1801 cgagtctgag gagactggca ctacaccggt accaggcgag agtggcgagg tcgatccggg 1861 cacggaaggc gtcggcggta tcgccgagcc tgtgccgccc gcctcggaag aggatagcgg 1921 cagcatcggc aagccggtgt tcctgccggg actggtgggg acgggcagcc cggcgatcgg 1981 cagctccggt tacggaggga gcggcatccc tgttgtctcg gacagcgagc gggagccgca 2041 gccgacgcct atcacacggg cgtggtctga taagctagca tatggcatgt tcacagcagg 2101 agttgcggct gcagctgcgg ccgcggcggt cctgtgggga cgtgtcatgt cttcacatgc 2161 cccgatacgc gggttctggc gactgtggag ccgccggagt ggtcgtcgtg tcgcggcaac 2221 gacgggacta ctaggcacgc atcgccggtc ttaggcgtat gctgagttat atttaacgtt 2281 gactagaggc acataaagga gaatgcagat atggggaaat attttggtac ggacggcgtc 2341 cgcggcgtcg ctaaccgtga gctgacaccg gagctcgcct acaagatcgg ccgctgcggc 2401 ggttatgtgc tggcgggcga ggcagacaag ccgaaggttg tgattgggct ggacacgcgg 2461 atctcggggc cgatgctgga ggctgcgctg gtctcaggcc tgctctcgat cggcgcgagc 2521 gtcgtcaagc tgggcgtcgt ctcgacgccg gcggtagcct acctgactcg tcaattggga 2581 gcggcggcag gcgtgatgat ctccgcctcg cataatccgg tcgaggacaa cggcatcaag 2641 ttttttggcg gcgacggatt caagctctcc gacgatacgg agctggagat tgagcggctg 2701 atggacggcg tcaccgatgc gctgccgcgt cctgagggcg gcgagctcgg cacggtaacc 2761 gtgctggagg atgcccagga gcgctacctc agcttcctga agacgacgat cggacaccgc 2821 ttcgacgggc tcaagatcgt cctcgactgc gcccatggcg cggcgtacca actggcgcca 2881 gcggttttcc gcgacctggg cgcggagatc gtcaccgtcg gcgccgagcc ggacggtctg 2941 aacattaacg atggcgtcgg ctcgacccat ccggagtatg tgcgcgagca ggtgctggcg 3001 catggagcgg atctcgggct atcgttcgac ggcgacgccg accggctgat cgcgatcgat 3061 gatacaggcg ctgagatcga tggcgacttc ctgctctgca tctgcggcga cgcgatgaag 3121 cgggctggca agctcaacag cgatacggtc gtgacgacgg tgatgagcaa catcggcttt 3181 ttcaaggcgg ctgaggcgct cggcctcaag acggctcaga cggctgtcgg cgaccgctac 3241 gtgatggagg agatgcgtcg cggcggcttc aacctcggcg gcgagcagtc cggtcatatg 3301 atcttcctcg actacaacac gaccggcgac ggtatcctga ccgcgctgca gctcgtcgat 3361 acgctcgtcg agagcggcaa gaagctcagc gagctgaaga cgctcatgag caagtacccg 3421 caggtgcttg tcaatgtgcg cgtcgccgac aaaagcctgt tccagggcaa tgtcgcgatc 3481 gacgaagcgg tcgcacgcgt cgagcaggcg cttggcgaca atggtcgggt gctcgtccgc 3541 gcctccggca ccgagtcgct gatccgcgtc atggccgagg ggccggacaa ggcggagatc 3601 gagcgctacg tggaggagat cgttgatgtc gtcaaagctc aactgggtta agcaatagcg 3661 aacagttgta gcggagatgg agagttaacg aacggctgcc agcgccgcag cgttgtcctg 3721 agcctttttg gtccagtggc gctgtggtgc ggctgtgggt cgagccctgg tatagacgag 3781 agacattaaa aggaaaatga gatgatgtaa tgatatgtac aagaccgttg gctccggagg 3841 aatacgattt cctgatggat atgcactatg agtccataca tattgtcgaa ggaaagccgc 3901 ccaaagagga gctgcttagc tctccgcatc ttatcaagta cagcgagaat tggggaagac 3961 caggcgaccg ggcgctaatc gcgctggtcg acgatatccc tgctggagct gtctggtacc 4021 gattatttga tgaaaataat aaaggctatg gctttgtgga tgcacatacg cctgagctag 4081 gcattgcgat attggcttcg cataggcagc aggggctggg gatgcggctt atggaggcga 4141 tcatccaaca agcgatatgt gatggttatc cggcgctttc cttaagcgtt gatccacata 4201 atcgagcggc tgttcgatta tatgagcggc tcggcttctc gtattgcggg acttcgggaa 4261 catcttggac gatgaagctg gatttggaca actcttaaac gtggctgcct gaaacatccc 4321 cgacgttttg gacgcgggat ggttgcaaac gagcatgaaa atgaatatga tagaaagtat 4381 cattccagag gagagcgagg gttgaggtca gatctagcaa tacaagcgcc agagcttgcg 4441 tgcgggatgg cacggagaag taatcatcat cccgggcaag ctgacgaggt ggaggtgttc 4501 gaatggttcg gcggggacct cccggtagcg gcattctacc gataagctgc agcttcaaaa 4561 cgacgcgggc aaccggtcgc acaaaggcgc agcgtaatgt ttgtttcagc atgcttttag 4621 aggttgttca tatattttca ctttcattcc cgcatgtcca cgatgccgat gtcacatcgg 4681 tcaggtcgga aggctttttt aagtataggc atcatgtctg tacttcttca taggggagcg 4741 cgctgttcgg caggaagcgg aagcttgccg cagccgcgcc gtctgtggag cacggatacg 4801 ttcgggaaaa aaccacatac aacctagagc cgcatgtcga ataggcagcc gtaggcagag 4861 ggcaaataac cctatacgga ggtctgttac attatgtgtg gaatcgtagg ctatatcgga 4921 aaacgcgata cgcaggaaat cctgctcgaa gggctcaaga agctggaata tcggggctat 4981 gactcggcgg gcatcgccgt cttcacgtct ggcggtctga ctgtgagcaa gtccaaggga 5041 cgtctggcga tcctggagga gaagctgcag ggcgcgccgc tgcacggctc ggcagggatc 5101 ggccatacgc gctgggcgac gcatggcaag ccatccgaca tgaactccca tccgcatacc 5161 gacacgacga ccaaattttc tgtcgttcat aacggcatca tcgagaacta tctggagctg 5221 aaggaggagt tgagtctatc gggcgtccag tttgtctcgg agacggacac tgaagtcatc 5281 tcccatctga tcgcttcggt gtatgagggc gatatcgttc aggcggtaca gcgtgcggtc 5341 aagcggatgc gcggcgcttt tgcgctgggc gtgctgaccg agcatgagcc ggatcggctg 5401 gtcgctgtcc gctatgcgag cccgctcgtc atcgggctag gcgaaggaga gaactttatc 5461 ggctccgaca tcccggcgat cctcgagcat acgcgcaacg tctacatcct cgatgacggc 5521 gaaatggccg ttttgacacg ggatggtgtc gaactgctga cgaccgaggg cgaaattatt 5581 tccaaggaaa tattccatgt cgactgggac ctgatgaccg cagaaaaggc cggattcgac 5641 cactttatgc tgaaggagat ctacgagcag ccgaaggctt accgcgacac gatgcgcggt 5701 cgcatatccg acgacggtcg caagattgtg ctgcctgaga tcggcatgac gccggagcag 5761 atcaaggcca tcacgaaaat ccatatcgtc gcttgcggca ccgcctatca tgctggactg 5821 gtcggcaagt cggtcatcga gtcgctggcg cgtatcccgg tagagacgga cgtcgcctcc 5881 gagtatcgct accgcaaccc gatcatcacg ccggagacgc tcgtcattgt cgtcagccag 5941 tccggcgaga ccgccgacac gcttgcagcg ctgcgtgagg cgaagcggtg cggcgcacgc 6001 gtgctggcga ttaccaacgt cgtcggcagc tccgtctcgc gcgaggcgga tgacgtcatc 6061 acgacatggg cagggccgga gattgcggtc gcctcgacca aggcgtacac atcgcagctg 6121 atcgcctttt acctggtcgg cctctatctg gcgcagaacg tcggcacccg cgatgcggac 6181 tggatcggca gcgtcacggc ggagctgcag cagctaccgg agcaggtcga atcgatcctg 6241 gcgcagtcga cggcgctcaa gcagatcgcc gagacgctgg cgcgccacag cagtctgttc 6301 ttcatcggtc gcggcctcga cttcgcgatc gcgcaggagg gctcgctgaa gctcaaggag 6361 atctcctaca tccactccga ggcgtatgcc gcaggcgagc tgaagcacgg cacgctggcg 6421 ctcatcgagg aggggacgcc ggtcatcgcg ctggtcaccc aggaggagct ggcggagaag 6481 acgatcagca acatcaagga agtgaaggcg cgcggcgccc atgtgctcgg cgtcaccaac 6541 gagagcaacc agcacgaggt cgcgaaatct gtcgacgagg tattcgccat cccgaacacg 6601 ctgcacctcc tgaccccggc gctgtcggtt atcccgctgc aactgcttag ctactacgcc 6661 tcgctggcat tggggcatga tgtggataaa ccaaggaact tggcgaagag tgtgacggtg 6721 gagtaagagc acaaaagagc aaaagagggc aacctaaacc attacgggtt gccctctttt 6781 ttcgatttca agctaacggc aaaacgagcg aaaatttata atggccgtcc atatgctcca 6841 gcaggatatc gccgccatgc aattgcacaa tgtttttcgt gatcgacagc cccaggcctg 6901 cgccgatctg aatatcctcg ctgcttcgag aatgatccgc tttataaaag cgttcaaata 6961 tcttttgttc ttgctctttc gttaacggct gtcctttatt ctcaatcatt aacgtaactt 7021 gtctatgatt agatgtcaca tgaatctcca cagtgcccgg ctttgtcgag tatttcagcg 7081 cattcatgag caagttgtcg atggcgcgcg ctattttatc actgtcggcc acaatcatca 7141 ttggcttttc gccaagcttt gttaggagag agatgttatt ttcaagggcg atcggttcaa 7201 attcaaagag caattgaccg accagcttgc tcagatcaaa ggaacttaat ttcagtcggg 7261 cttcatttga agtcaactgc gtatactcaa ataagtcgtc cagcattcgt tttagatgga 7321 ccgctttatt taaggtgttg tcaatgaatc ggttgtattc ttccttggat tggaaagcat 7381 tggcccgcag aagctcgata tagccgataa tactggtaag cggtgtacga aggtcatgcg 7441 atacgcctga aatcatctcc atttttgatt tttcgagttc gcgctctcgg acgatttgct 7501 cctgcaagcg ctcggccatc agattaatgt tggttgcaac tctccccagt tcatctcttc 7561 gttcgaccgg aacgcggtaa tccagatcgc cctcagcaat aatttgcagt ccccactcaa 7621 gggttacaaa gtcggttacg atccgcctgg tgagcaggaa aaaagacgca acaaagaatc 7681 ctattaataa ggcaagggtc aaaccgtgga atcccgggaa atgaaagtaa tcaagcacat 7741 aaataacgag tatggtcaaa atgaaggcga taaaaaaact gtacaccgca ttcaacataa 7801 aattgacttg tatttttttt ggcctgtcct tttttctagt caactttata gcccactccc 7861 cataccgtct ttatatattg tggggctcta ggattgtcct cgattttttc cctcaaattg 7921 cgaacgtgga ccatgacggt gttatccgaa tccccaaacg gttctttcca cacgctctcg 7981 tatattttct ctgtgctgaa cacttgagct tggtgggttg ctaaaagctc gaggattcca 8041 aattccaatg gcgtgagcga gatatctttg cctctcaacg tcacagcatg cttgttccga 8101 tctatggcca aatcacggat atgcaggatg gcgcgctcgt tgacttttcc ttggagcgca 8161 ttgcgtcgga attgggcttt gaccctcgcg agcaattcta aaggattgaa gggcttgacc 8221 atataatcgt cggctccaga tgtaagtccg gtaattttat cgatatcctc ttgtttagcc 8281 gagagcataa taatcggaac atccgacttc tccctaatct tgaagcaggc atgaatgcca 8341 tccatcttgg gcatcatcac atccaggatc acaagctgga catccaccag ctcaatcgtt 8401 tttagagctt ctagaccatt ggcagcttct acaacctggt atccctcgtt ccgtaaataa 8461 acatggataa tatctcggat ttccgaatcg tcatcaacga ctaagacggt gttcatagca 8521 tggactcctt taatgaggct ttcatttttt acggcataca tatacgaaag caggagggaa 8581 attaagcggc acgaacccaa tctcctccaa gataaatttt tcggacaata gctttttcat 8641 ttgcagggaa tactgaaagg cgataaactg accgcccggc cttaaagctt gatgaacctg 8701 atccaacagc ttcattttaa gcgcaggagg gaaattaaaa aacggcagtc cgctaataat 8761 gcaatccaac gcgttcaagc ccgcacgaga caaagcgtcc gtgagttgac aagcattcgc 8821 atgaacttga aagtcaggat aatcctgctt tagattactc cgcatggcct catccatttc 8881 aaacaataat acatgcatgt tctccgtcgt gtgttgcttc agcacacgtg tgattgctcc 8941 tgtccctgag cctaactccg ccacagcgct tacctcatgc caggcgacag cattagtcat 9001 gcgggtggac aaatgttggg agctgggaat aacgctgccc acttgtctgg gttgtctaag 9061 aaagctgcga ataaactgac catatacatt tttactcaag ttgtccacct cgtctttaga 9121 gttccattct agatcgatct cattcaaaaa tagttgcccg caatagagcc tgcgccaaaa 9181 aaggctgccg tccaaaaaat ggcgctgcta taagaaagta cgataaacgt acgggcattc 9241 acccggctta agccaaccag gagaggcatc agatatctaa ccacgggaat gaaaaatccg 9301 atgcaaatcg cccattttcc gtgtttgtgc aacaagagcc gggtttttaa gaaatggcga 9361 ttttcctgca atttcgaacc gaagtatccg ccaaaaatgc gacctgtcgt ataggagatc 9421 gtgacggcaa ttaaaagtcc ggacaaaatg gacacatacg ttaggaatgg attgagaatg 9481 ccattcacgc tcaggatgga gcctgtaacg atcgttactt cgttcggaac gggaatgcca 9541 aagggaccta aacaaaaagc aaggaagaaa agaaaatatc catatgcatc aattaagttc 9601 aaaatggtgt cgttgatcat cgatatctcc ttatctcgat ttgatataag aagattaaca 9661 agaacttttg agattccacg ggggattttt ctgaagagtt tctgaagaca agaatgtact 9721 ggaggattat gatggagact gaagggttca aggtgggggc gtgggggagt gcgcgggcat 9781 aatgaaggtg cgacacagcg gcatctgttt tatggaccca tttgcagact gacaacgtaa 9841 aaaagcccgc tcggaggtat cgctactccg acgggttaaa cttccgttat gcatcttctt 9901 gcggttcttt taaacgttca tcgactaaac acttgtcatt tccatcctgc accccaaagt 9961 atctcagaag gtagccatct ttgaactttt tgcgtaatgg atcaatcaag tgatcgttat 10021 cgaatgcgat atgaccggta agatagagga ccaccagaaa ttcttcaaaa cgcttattgc 10081 ctaagtaggc ttcctcctcg tcaaatccac tgaaaacatc cagttccaac tcaagaagga 10141 aagacatgcc tagaggcgtt gccccagaca tagttacgtt atcttccgaa ttcaagatca 10201 ggttgatttc acgagagatg agatgcacat cgtcatggtt cagcatcatc aattgagaaa 10261 cagcttcctc atcccgaaag atataggctg tgaccgctgt ttcaaacttg gcataggggt 10321 cattttgcaa gctcgaaaat tgatccacat tcacttgctg tgctttatat tttgtgacca 10381 gatagtgatg aatatcttgc aatgtaaaag gattgggtat tttgcattca aggaatttct 10441 cataaagctt ctccaagtta atcatgagcg gtcagacact cctatatcta ctattctggc 10501 gttatcctac cactcccgtc gccaatcatg ctccagcttc gacgccgtgt cgatggcgcg 10561 ttcctcgcca tggagcttgg cgagcaggtg cagcgccgcg tcgatccccg cggtaacgcc 10621 ggccgaggtg atcagcttgc cgttgtccac gtagcggaca tgctccacca ctgtcgtgct 10681 ggggtgggcc gcgcccagca gcaaatccat ggctctcctg ttggtggtcg cccgcatgcc 10741 ctcgagcagg ccggccttgg ccagcaacag cgaccctgta cagaccgata gcgtaaaggc 10801 ggcccgctcg gaggtttcgc gaatccagcg ggttagccgc tcattatgca tctccttgcg 10861 gctcccccaa ccgccgggta cgatcaggat gtccggctgc gggcactcgg aggacgcgaa 10921 ctgcggcacg atcgtcaggc cgctgatcgt gcggatcggc tcggttgact ccaatgctac 10981 agtatagaca tgaaaatcct gcccccaatt gctccctacg gcaaacacgt caaacggtcc 11041 tgtcacatcc aaagcatcca catgctcata cactagcacc gccacttttt tcgcatgttc 11101 cacgctgaca cgctcctcca aaaatagaaa agcatccggc tcctagggcg tgtctgcaaa 11161 cccgctcagg ggcatcttag accgcctttt cgccccctgc ggcgtcactt ttgcttgccg 11221 tacccgtagg taacgccttc acaaaagttc cttgcatgga acgaaaattc agcccaatct 11281 gctaccctcc gagtatgcag acacgcccta acaaaggaac caaatgcttt gcccaggcga 11341 acggcttgtt gtcggatacg ctcccccgta gtgatctacg ttttcgccag ttacgcaccc 11401 catttattta ctgtttatta taaatcgtgg aagggcggag ggcaatctat ttcttctgaa 11461 gattcgaatt tcatctaagt cagtagcagt cgatcctttt gttcggctgt tttttgttga 11521 acgaacggac tgcaggcttc agaatgaaag aataatcgtc gagcggaatt ttcccctttt 11581 gatataattt tcattggagg tgacggtgct gtggaaatgc agaaccaaat tgaaatcgtc 11641 gtgaactata ttgaagatca tgtaaaggat ccctttgatt gcgacagact ggcggagata 11701 gacgcttgtt cgaagtctca ctttttcaag cagtttacgc tgctgaccgg gtatacgccg 11761 atgaattacg tgcttcgaag aaagcttcaa ttcgccagca agcagctcat tacaggcaaa 11821 gaaaaaatta tagacgttgc cttcgaattc ggattcgagt cgcacgacgt attcagccgt 11881 gcctttaaaa tcgaacatgg cgtcttggat tattatacga cattacaatt cttcgagagg 11941 gttgaaaagc gataatttgc ttgtttagga ggcaaagatg aagagatata cgatccatta 12001 catcccgcag cctaacttct acgcgtgtga tcaggcttgt ctggcaatgg ctgccgggat 12061 cactattgaa gaagccatga ttatgatggg ggataaaagg ggcgttggct cgtccgtatt 12121 gtacaaagcc ttaaaaaagt gcaacatcgg atatacaagc tggcgccgat tcagcagtat 12181 ggaagagttg cctccgcttt gtattctagg cgtaaagttt cccgattaca gtcactctgt 12241 tttgttttat aacggtgtgt tttatgatcc ggagtatggc gtcatgacgc attatacgcc 12301 gaacggagaa atagaacatt acatagaact atttattgat gatgcttacg aaggattaga 12361 cccgacggtg aagctgccgg aggattatca gtctgcgttt gagcatgatc ccgaggcatt 12421 cgagctgttt catcaattgt cgtatcccga gaaatcaaag ttaataaata aaatcagtca 12481 ctacaaagat ccaaaaatca gaaaagcgaa tattagcaag agtattcatc aattgaagat 12541 gcgaaagcat gatatagaat gagcaagagc ctcagcctgt ttttttggct gaggctctgc 12601 tcttcaaagc tatgcccact taaaatcagt cgaacgacat gatcggagga tcgcgagtta 12661 gatgcttgcc tcgcacttac atctcgattt gtcctgccga tgacgtggat ttcgcgtgag 12721 agccggtgcg gatttgatgc ttggattttc tgaaatagaa taactcatag attacaggta 12781 cgacgaacag cgtcatcagt gtagcgacca gcagtccgct gatgaccaca gtagccaagc 12841 cgctggacac caggcttccg gattcgctgg tacggaacaa taacggcatc atggccagga 12901 tcgtagccat cgctgtcatg agaatcggac gcaggcgaat ggctgctgct tctgtgatcg 12961 cttctcgaat catcatcgtt tgttcatttt gcttgatctt gtcgatgagt acgatggcgt 13021 tggtcacgac gatcccgatg agcagcaagc cgcccagcag cgatgtgacg tccacagagg 13081 ctccgctgac gataatgccc agtatggcgc cgattgccgc aagcggcagg gtgcacagga 13141 taaccaacgg tgtgcggaca gacttgaagg tcacgacaag gatcagatac acgacgccga 13201 tggataccaa catcgtgagg aagatgtcgc tgaagtcgtt ggcttgctgc gatgaggcgc 13261 cgccgatgat gacatcgata ccatcttcga tattcaggcc cggttggctc cccgagccga 13321 atatggcctt ctgaatgtca gccgatacga gcgagaccat ggacggctca atcgtcgcaa 13381 tgacacgaag ataggacttg ccgtctttct ccaatatgcg ccccgttttc aactcgtttt 13441 tccattcccc aatcgaggag gcaggaacga cgccttgaga cgtctggatc atcagctgat 13501 tcagctcggc agtggtagcc gatggcatca aaggctccag atacaccggg gttggtctgt 13561 cattctcagt caccgttccg agcgggatgc gattgaacaa gatcgatagc tgttgggcta 13621 cctcctgcgt atttgctctg gccggatcga cgatcagaga cgagatttgt tgcttatcct 13681 gctcattgga gctggcttcg gtaacccctt caatgccttc aatcgattgc aggatttgat 13741 tggccagctc ggataacgta tcggggtcgc tattggcgcc gacaacatcg atcgtgatcg 13801 cggcattgct gctgcctgtc atcgtcccac tgccgacggt cagcgtcgct tccggatagt 13861 tgcttttttg agcttcgatc gcctggatga caggctcggc attgacatcc tttttcatct 13921 tcagcgtcag attggcgatg gttggcgagc cgaccagccc ccattcggcg ccgccggagc 13981 tattgcccat ctgtgtatag atgaagtcaa tgtcgtcttg ctggatcaat tgcttctcga 14041 gctccattgc tttttctgca acaagcgccg gggacgtctc ggtcgggtat tcgaggctgg 14101 ccatgacaaa ctctgcctcc gagttatcga taatgccctg gggtgtgctc agataaagcc 14161 cgactgatgt agcgaacaaa agcagcgtca tggtgagcac aagccatttg gtgttcaatg 14221 accatttgag cagcgagaca taccgcttgg gcgccttgtg ctttggcatc ttggcgttgc 14281 gcagcattct tgcgctaagc aacggcacga ccgtcaaggc gacgagcagg gaagacaaca 14341 gggagtaggt cacggtcaga gcgattggca gcaaaaacga ttgcaagccg ccgccgacca 14401 ggccgatcgg cagaaaaacg gcgacggtgg tcaatgtcga agaagtgatg gcagccgtca 14461 cttccttggt cgcgtctacg atgtgggatg tcacgccatc tttttgcatt cgacgataaa 14521 tattctccac aacgacgata ctgtcgtcca cgagtctgcc gacggacaca gccaccccgc 14581 cgagcgtcag gatattcaac gtaatgccgg attgatacaa caaaaacaag gtcaagccaa 14641 gcgacatcgg aatggacacc acggtaatca cagtcgtctt caggttgcgc aagaaaaaca 14701 agatgacgag cgttgcgaaa aaggcgccca ccaatacctc aagcagcatg ctgtttacag 14761 aggttttgac catgtctcca gtggagaaat agacgccaat gcgggcatcg acaaattgct 14821 cgtcaagctc cacggccttt tccctgacca tctcgcttag actgacagca ttggcctggg 14881 cttctttggt gatgatcata attacggcat cctcgccatt aatccgcgtc aggttgccct 14941 ccgtgctttt atactcgaca gaagcaagct cagagagctg tacatctcca gagacaggca 15001 gcctcttcag ttcatccagc ccttcaatat ggccaatgac cgtaatggag ctgtttttat 15061 tgtcgacaag actgctgccg acggccaggc cggcgttttg cccctgcaag gctgtcagta 15121 cagcggtgac aggtatgttg gatcgctcca tcgcggcttg atccagttcg acggtaatcg 15181 gctgatcgat ttttccatac gtagttacac tgctgacgcc ttcgatgctt tggaattccg 15241 ggaggatttg ctcctcgacg aggctgaggt tatgtttggt gatcccatct gggaaggtga 15301 cggatacatt ggcaatcgag atcatcgcgg tattgagcag ggtaatataa ggcttggagg 15361 tgttaggcgg cagctcgaca gcctggagcg cctcctgaac atctgttttt gcctggcgca 15421 tgtcggtatc gctatcgaac atcaagtcca ttttgacgta accgctaccc gattcggaga 15481 acgtttcttt tttgcccctt atgccgatta gcgccttttc catcggttgg gtgacagatt 15541 ggttaagcgt gtctgcatca taaccctgac cgatgacgat gacggagatg ttagggttgt 15601 cggagtaagg caacagctcc atcggcagca gccggtagct cacgataccg aggatcaaga 15661 tgagcgcgga ggtgatgaag acggccgatt tattgcgaaa agaccatttc gtaaaccaaa 15721 tcatagcgaa gttccacctt tcattcaaag gattctgctc agacatcgaa ctccaattgg 15781 aaacctgaca tatcgtggaa tatcgaaatt aaggcgtgct aaagaagctt gagccctgga 15841 caggtacggg tactgtgctc aagtcatagt ttgggtgatc gctttacttt atccatggaa 15901 cctgcagtga atggacttac gttcgccagt ccagcttttt cagggcaagc gctacggcaa 15961 agatgagcca taagcataac gcggctacaa gcgaccagag gcgaaggcca tagctatgct 16021 cgaagatttc gttcagcgcg agcgccgcct ggccggtagg cagcaagtaa gaagtgaact 16081 gtaggaacac aggcagcttc tcgatcggca gcaggacggg actgaagaag gtaaccgcca 16141 aataaggcag ataagagtag atggcgaaat gcaccatcgt tttggcgtag ctgccgatcg 16201 tcgagccgac aatcgtcatg cttgccgcag ccagcagcgc aatcggtact ccgcttgcca 16261 agtcgagcag cgggatgtcg agcagcaaat ggccgaacag catcgagctg agcatggcgg 16321 gcaaggcgaa cacgatactc tcggtaaaca gcgcagctag aaacgagctc ttgtgcacgg 16381 acaagctgcc ataataatca agctcgcctt cgactttcat cagtgctgtc ctctggatgg 16441 cgaagcttac gctgccaaag ctgatggcca tgacgatatt tcccgccagc atccaggtcg 16501 cgtccggccc cgtacctacg tattgcttga gaatccacat aaagccgagt ggaaggacca 16561 gaccgatgag caacaggaag gggccggctg atcgataatc tgtaatcaga agtcttagca 16621 acaagcggta ttgactggcc caagacaatt gagcttgctg aggcggttga ttcatgagac 16681 gaggcattgt ttcagtttgc aatgcgatct cctccactta gttcgaaata aatatcctct 16741 agatttgaag atacgatacg gaagtccatc atctggttga ggttgggaag cagctcggaa 16801 atggccggtt gaacggcttg ctggggtagt gtgatcgtat agcggttcgc tccgagttga 16861 acggcatgag gccatttcga gagaataaag gtggtaattg cagtggcgta atccgggttg 16921 atgacgacct caagtcggac attttgcttg atatgagcct tcagctgctc cggcgtgcct 16981 acagcgagta ttttcccttc gcgcataatt ccgacacggt tcaacgtgtg ctcggcctcg 17041 acgacattat gggtcacgag gatgacggtc ctgccctcct gagaggtctg ctggattctt 17101 ttccagaccg ctcgccggat ctcgggatcg agatcgttgg tcggttcatc gagaataacg 17161 acgggacgcc ccccaatgat cgtaacggct atagcgacaa gacgtcgaag gccgccggac 17221 aagatttgga ttttcttgct gagatgaggc gtaagaccga attcatgaat cagcgactcg 17281 gcatcctttt tggcttgtgc gggggggacg cctcgcagtc gagcggtcac ctcgagcaac 17341 tcgagcggca tcgattgcgc tggaagccag atgttctgcg gctgaagcga gacaaagcgg 17401 cttgcttccc gaggattcct gatcatatcg acgtcaaaca aacgtatcgt accgcttgtt 17461 ggtttgacca tgcctgccaa ttggcggaca agcgtgctct tgccggcgcc gttaggaccg 17521 agcaagccga acacctcgcc ttgctgtacg gttaaagaga cattgtcgtt ggcgggcttt 17581 gcgctcttcg ggtagatttt aaccagattt tcaatgacaa aggccgtttg catacgttca 17641 cctcttcttc atcaatgatg gaatcgaatt attccagcgt ccaggggaag gaaggataat 17701 cgatcggatc cggcagtggc tgatcggata cccccaataa atcgcatccc gtccggaaca 17761 aaatattaaa tgcgtcttga tgcatgccga ttagcttgtt gcccaaaatc gtattgaaca 17821 ccaggcaaga ctgggcggtc gcctcctcca acgatttgcc ggcatctact aacaacgagc 17881 acagaatctg gatctccagc ttcgtaaagc gattcaacgc ctccacgcag gcgggaggat 17941 gcacatcggg cgcgccaagg atctgcatca ccaagcgtcc gaacaatacc gtatccttgt 18001 gatcgaagca gtggatgaca gagtatatcc aacgccgctg ctgctcctcc agtgaatgtt 18061 tgccggccaa cgcccggcgt cttgattcct ccagataaga taagccggct tcgaggatcg 18121 ttgagtagag aagaattttg gagccgtaat aatgatgtac cagaccgtgg cttactcctg 18181 cttcggcggc aatatccgaa atcttggtgc caaggtaacc ggtagatgca aaggcatgaa 18241 gcgcagcgcc gagaatgcgt cggcgttgaa gatcggtcgc gcttgctcgt gttccagcgg 18301 ctgattgttt gtaatggctt tgctttcgca ggggcttgga tgccattact tcacctcctg 18361 ttagcgttga atagttgact ggccaatcaa ttaatttgaa ttatgaacga atttacagca 18421 tgtgtcaata attccaaata aattatcttt atcgctgacg aattggttga ctttttcatt 18481 gacaatatag ttgactctac ttctgaccca ttttcagttt ccatatttaa cagtttgatt 18541 gacaaggtta ttaattgttt ctatgatgct tgtccaagtg tcgagctgaa tgttgatgtt 18601 tttttcgtga tttttaggta ggctttcatt gccttcgaca ttttaggttg aatatttact 18661 atatttttgc tatcaatcta gttgaagatg ttgttgacaa taaaagtatt aaattgtaat 18721 attaatctat ctttccattt gaaaacaatc aaaatgtgag gtggtatcat ttggacaaag 18781 gtgtgcccgc tctaaggatt cgccagtttc ttgtcgaaag gatcgcttgc atgaccaaac 18841 aagacgaggc gaatgtcaaa acaagtcttc catttgcaag ctatggtctg gattcgtccc 18901 aaagtgtcga attgtcagcc gaactagagg atatgacggg gcaatgcttg gagccgacaa 18961 ttatatggga ttatccatct attgacaaat tagtggatta cttggttggc gatgcaatag 19021 gagctggaca agcctccgca tgtcaagacg atatgacgga gccgatagcg ataataggca 19081 tgagctgtcg attccctgga gcgccagatc tcgacgccta ctggaagctg ctgaaggaag 19141 gcggcgtcgc gattgcggat gtgccgcgcg agcgctggga tactattgag gaacagggga 19201 tgaagaaagg cgggtttata tgcaacatcg accaattcga tgcctccttc ttcgagattt 19261 ctccccgaga agccgcgcgg atggacccgc aacagcgctt gttgctggag acctcttggg 19321 aggctataga agacgcaaag gaagtgccgg ctcgctgggc aggacgccgc atcggcgtat 19381 ttgttggtat tgctcagaat gattacgccc aattgcaatt gagcgagcaa ctgccagccg 19441 atgcttactt cgggtcaggc aatgcgctca gtatcgctgc caatcggctg tcctattttt 19501 acggatttcg cggacctagt atggcgattg atacggcctg ctcttcctcc ttagtcgcgg 19561 ttcatcaggc ttgccaaagc attcgcaacg gtgaatgcga ggcggctttg gcaggcggtg 19621 ccgggctgat gctgtcacct gctatatcgg ctcacttttc gaaaacggga tttttgtcat 19681 cgagtggagc ctgtcgtccc tttgaccgcg acgccgacgg ttatgtacgc ggcgaaggag 19741 tgggcgttgt cgtgctgaag ccgttgtctg ctgcgctgcg ggacggcaat gagatctatg 19801 ctgtgatccg aggcggagcg gtgaataatg acggcagctc gaacggctta atggctccaa 19861 acggccaggc gcaggaagag ttgctgcgcg aagcctaccg gcgagcaggc ataacgcccg 19921 caagcgtagg atatgtcgag gctcatggta caggcacgag ccttggcgac cccatcgagc 19981 taaaagcgtt aggcgctgta ttgggagaac agcgaggggc ggagcggaag tgctcgatcg 20041 gcgcggtaaa ggcgaatatt ggccatttgg aggcggccgc aggcatagct gggctgatca 20101 aaacagcttt gatgctgaag catagctggc tggtgcctac tgcgaattac aagactgcca 20161 atccgtacat cccgatggac cgtcttgcgg tttccatcca acagcaatcc gagccgtgga 20221 attgcccgga ggaggagaag cgaatcgccg ggatcagctc ttttggcttc ggggggacca 20281 attgccatct tgtgctggag caagcgcccg aggcgcctgc gagcttatcc gcagagcagc 20341 atcagcagcc agagcagccg gagaggatgc actatatgct actctcggcg agaagcgagg 20401 catcgctcag agcgatggcc aggctagccg tgtcggcgtt gacgcgtgca gaggcgaacc 20461 catcgctgac ggatctctgt tacacgttat gcgcccgcca ttctcatcat gatcatcgga 20521 tcgccgtgat cggccatgcc gcggccgata ttgccgcttc ccttcatcga tacataaata 20581 acgagccatc atccatggtc tatctagccg gagaggagca atcatcagca gatatagaag 20641 cggagattcg acacgtatgc cgcagtgagg acgggctgcg catcgccaat ctagccgaac 20701 gtacgattgc gggtacagat cataatacaa gagcggaggt tatagcgaag ctgtatatcc 20761 tggggtgtga gctggattgg gagagtctgt accctgaggg gcgagctgtc aatattcctc 20821 cttacccgtg ggatcgcaag cgctactggt tcaaagcggc gggcggggaa gccgagctgc 20881 cgggcgaagc tgaggcggag acggagcttg aagcctacta cgagtcgctt gcccaggatc 20941 tgacggcaca cgagcaatat ttaagctttg cgcctttcgc tcaagccgac ccttcttttt 21001 cctgggtatt ggccctgtcg gagccgtctc gctatccgga ttcgtatgcc gcgatgtcgg 21061 cggcgcaggc cgagatgcgg cgcgtcatgt tccgacacgt taagtgggat gctgtgaaac 21121 gaatgatgga aattggttgc ggctacggct cggacctgat caagctcgcg cagtctcagc 21181 cgcatttgag cttgacaggc tataacatat cggacgcgca aatcgcgatt gctcgcgaac 21241 gtgtaagcgc tctatcgctg gagaaccgca tacagttttt taagagagat gtccaacagg 21301 atgccttgtc aaagcaatat gaatgtgcgc tggctgtaca aatcctccat catcttcctg 21361 ataaaagaaa ggcccttgga acgatggcgt ctcatctcgc agccgggggg ctcatcgtga 21421 tggccgagat gatgtccaat acgtcggaga ggctcgagca cccgcaatcg agcgcctatt 21481 acgacacgaa ggaggaatgg gccaatctgt tggcggagca tcagcttcaa gtactggatt 21541 gtatcgatgc aagccgggaa gtcgggaatt tcctcgatga cccgcaattc tatgacaatg 21601 tgctgcagtt gcagcgcaat cgaagcgaga cggtgaggaa tcatttggag ggtccgcatc 21661 tgctgggcgg cttgctgcgc cgcaaggtcg ttacatacgg cttgattacg gtccaaaaaa 21721 cgtcctgtct ccatacggac tcgcttagaa agctgaatct ggagcgtctt aaccatgcca 21781 ttccttatcc tgtcgcagct ggatggtcgg gcgaaaccgc gcacacgacc gatatctcct 21841 ccactgaacg gagaacggtc cttaagccgg acgatcaagc ggggtacgag cgaatgctgc 21901 gggatgcagc ggcagaggtg ctggagatcg accctgagcg gctggatata aatagatcgc 21961 tcgattcgtt ggggctggat tcaattatgg cgatcgacct gaaacaaaaa atcgaacggc 22021 agctcgagct tgccttgccg gtaaccgagc tgctccaagg gcctagcata cggcagctgg 22081 ctatcaagct gacagaggcg gcatttgaag agacggcggc agccgatacc gtgatgagcc 22141 tcgaagacaa ggcgagcggc gcaacgagcc cggagcaatt gttggcgtcg ctcgacaatc 22201 ttccaaaaga agagctcgaa agattaaagg ccatctacct gcaggacagg ggggagcaga 22261 agtgatggaa aaaccgttgc aatccggcga gcatcaggag gctgatgacg agcgattgca 22321 gctggcgcgg atgatgtgga aggccgcgcg cggcgagctc gaaacggggc cattaagcta 22381 tggtcagcag gcgatgtggt ttattcacca gatggagccg cttgacgctg catacaacac 22441 gcattttgct gccaggatcg tagcaggcat cgatgtcgct gcgatgcgcc aagccttcca 22501 gggcttggtg gatcggcatg gtgtcctgcg cacgagctac cgcttgcaag gggatgtgcc 22561 cgaacagcgc gtcgaggctg cggcagaggt agcgttccgc gaagtgcagg cagttggttg 22621 gacggaggag aggcttcgtg cggtattaat agaagaaaca cgtcgaccgt ttgatttgac 22681 gacaggacct gtcatgcggg tccacctgta ccatttgccc ttcgatcaag cagtcttatt 22741 agtcacgatt caccatattg ctatcgatta ctggtcgctt gctgtgctgc tggatgattt 22801 ccgtcgccta tacaccggac agcccttgcc agcgctcgca gcaggctacg ataagtttgt 22861 gcgttggcag cgggagttca taagcagccc gcgaggcgtt caatccggtg attactggca 22921 cgaccggttg tcaggcgagc tgccgttgct tcagttcgtc aagaccgcct ccgcagcgcc 22981 tccgctggcc gatgcccatt cgagcggcac cttcatcttc caactagacc gtcacttggc 23041 cgagcgactg aagctgctcg gacagtcgct cggcgcgaca ttgtttacgg tgctgctggc 23101 tgcatttaac gtcatgctgg ggcgctacac ccatcaggat gacattgtcg tcggcacgcc 23161 gactgcagga cgcaatcgac cggagttcga agccgtcgtc gggtacttgg tgaatgcggt 23221 cgtgatccga accgcgatac cggccttgca gccctttgcc gaatatgtgc ggcaggtaag 23281 gcaggacgtg ctggaggcga tggagcatca ggattatccg ttcccgctag ttgtacaaga 23341 gcttcagccc ttgcgacatt tgaagcggac gccgttaatt cgggcgatgt ttgccttcca 23401 gaaggcgccc aggctggagg agcaaggtct gacatccttt atcctgggtg ctccgggaag 23461 caagctgcag tttggcgata tggagctcag accgctggac ctgccgcagc aggaggggca 23521 attcgatctg acgctgcacc tcgatgcgac gtcgctggcg ggcgctatcc aatacgacac 23581 ggcgctgttc gatcgggatg cgatcgagcg gatggcgagc cactacgaga cgttgctggc 23641 ggggatcgcc gccgacccga actgccgaat cggtgagctg ccgatgctga cgccgggcga 23701 gctcgccgag ctggagagat ggaacgccac ggcagcgccc tatgagcgta ccgcctgcat 23761 ccatcaactg ttcgagcggc aggtcgcgcg agcgccacag gcggaggcga tccgctgcgg 23821 cgagacgcgc atcagctatc ggtccctgaa cgaaagggcc aaccgactgg cgcactatat 23881 gcaggctgag ggcatcggcg cagggtcgcg agtgggcatc tgcctgccgc gcacgccgga 23941 gctgatcgta gtggcgctgg cggcgctgaa ggcaggcgcg gcctacgtac cgctcgatcc 24001 gagccatccg gcggagcggc tcggcgatgt gctgaccgat gccggggcta gcctggtctt 24061 gaccgacgag cggcacgcgg agcggctgac ggaggggctc gccgctgtgc aggggcgaag 24121 ggcggatagc gccggagccg gagccgatac atcggatcag gagagggtgc tcggccaggt 24181 ccaaggcgca gactccggtc ctacccgaga ggctggctgc agccagccat gcgaggcgcc 24241 ggagccgata cgtctgctgt gcatcgaccg ggaggcgaag gcgatcgccg ccgcaccgtc 24301 gagcgccccg gtctgcgcgg ccgacccgga cgccgccgag cggctggcgt acatcatcta 24361 tacgtcgggc tcgacaggca agcccaaggg cgtaatggtg cagcatcgcc cggtgatcaa 24421 tctgatcacc tgggccaaca cgagcttcgg catgagcgag cgggatcggg tcctgtgggt 24481 gacctcgctc ggctttgatc tatcggtgta cgatctattc ggcgtgctgg cggcaggggg 24541 atcgatctgt atcgccgacg agcaggaggt gcgcgacccg gagcgtctgc tgacgctgct 24601 ggagcgcgag gagatcac //