LOCUS       c00264_3300013..       14274 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300013004.a:Ga0164293_10003038.
ACCESSION   c00264_3300013..
VERSION     c00264_3300013..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-24 12:20:15
            Original ID  :: 3300013004.a:Ga0164293_10003038
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14274
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14274
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11760:14274](+)"
                     /cutoff="20000"
                     /detection_rule="(hglE or hglD)"
                     /neighbourhood="20000"
                     /product="hglE-KS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11761..14274
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(hglE or hglD)"
                     /neighbourhood="20000"
                     /product="hglE-KS"
                     /protocluster_number="1"
     cand_cluster    1..14274
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(hglE or hglD)"
                     /kind="single"
                     /product="hglE-KS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14274
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="hglE-KS"
                     /region_number="1"
                     /rules="(hglE or hglD)"
                     /tool="antismash"
     CDS             complement(2..865)
                     /locus_tag="ctg264_1"
                     /transl_table=11
                     /translation="MAKERPPLEEMTLRQLRKVASEYSISRYSRMRKSQLLASIEDVQN
                     SKFSLSSSPNLEAQKTVEAAKFELGQEDLTGGSLADVDEALTDLPAGYGDSRIVLLPRD
                     PQWAYTYWDIPNDHKEAIRRQGGQTLALRIYDVTDIDLEYQSPHSIQEYPADELAREWY
                     LPIPVSDRDYVIDIGYRTANGGWLVLARSARVHIPPVYPSDWIEDVFITVDFEEDLRAK
                     TYYELVPPAKKLSIIAAAAAGDGNPIYEQIFDLAESAEAQRVAGSLFGSMQHVPGSAAP
                     EQAISSY"
     CDS             complement(1281..3566)
                     /locus_tag="ctg264_2"
                     /transl_table=11
                     /translation="VRIPLDYYRILGLPLAANEEQLRQAYSDRIAQLPRREYSITSISS
                     RKRLIEEAYMVLLDTEKRKSYDQLYLAHVYTPNTTADQVPPETLPDSNSKDQDAQSLSI
                     EITPEQFIGSLLILQELGEYELVLKLGRPYLVNKSSPVNLKTDHSVTRSQIPDHPDLPD
                     IILTVSLACLELGREEWQQGHYENAAVSLETGEELLAREGLFPSVRAEMTADLYKLRPY
                     RILELLALPQIEIPKRRQGLELLQSILEDRGGIDGTGNDQSGLNIDDFLRFIQQIRHYL
                     TVAEQHKLFELESKRPSPVAIYLAVYSLIARGFAQRQPALIRQAKQMLMQLGKRQDVHL
                     EQSLCALLMGQTEESTRVLELSQEYEALAFIREKSQDSPDLLPGLCLYSEQWLQQEVFP
                     HFRDLAKQQASLRDYFADRQVQAYLESLPTDAQITNEWAAINHQSFLQSDLHHFHYHTS
                     NTTQKQEHDHQPANPELPVTHSRPESESTQDSIPRWNRQPGNRSVGNQASQIPPTVTTP
                     HKRPQPSNGHPSPATNHQPPRRRRKPLANNLFRRFIRSQTNFLSRLDPKTRLVWLVFFL
                     LGGVLIFSLLVSTTFSLVKNIFFPSPSLRGQQLAIELSQPPIPIPDPNTQEELSDKELT
                     KETAKKVIETWLSAKTAALGPNHDIDALNEILTGKVLSQWLSVAQQEQESNRYRHYKHN
                     VEIVAISKKGIDEDNISIDAKVQEVTKFYQNSQQKKSSDETLRVRYDLIHKEGKWLILR
                     MSVIHTFL"
     CDS             complement(3832..4140)
                     /locus_tag="ctg264_3"
                     /transl_table=11
                     /translation="MTGRELRQLLINKWGQAYDLQFRRTQGKIFLQIMWKYFGQVSFPL
                     SETDYQDHLDSIANYLNALGGTQQVQTFITETKERPRLGKAVSIPLDLGERASEWIV"
     CDS             4436..4975
                     /locus_tag="ctg264_4"
                     /transl_table=11
                     /translation="MAQFSESADVPDMGRRQFMNLLTFGTVTGVALGALYPVVNYFIPP
                     AAVGAGGGTVAKNELGNDVSVSQFLDGHNVGDRTLVQGLKGDPTYIVVESKEAIADYGI
                     NAICTHLGCVVPWNVAENKFKCPCHGSQYDATGKVIRGPAPKSLPLAHAKVTDDKILLT
                     PWTETDFRTGDAAWWA"
     CDS             5093..6094
                     /locus_tag="ctg264_5"
                     /transl_table=11
                     /translation="MRNALTPTRLTRTAKAMFKTLLIAIATVTFFFTSDIVVPQTAAAY
                     PFWAQETAPATPREATGRIVCANCHLAAKPTELEVPQSVLPDTVFKAVVKIPYDPSVEQ
                     VGADGSKVGLNVGAVLMLPEGFKIAPEDRIPEEMKKEVGDMTFTPYNDETDNVFIVGPL
                     PGEEYQEIVFPVLSPNPATDKNIHFGKYSVHVGGNRGRGQVYPTGEKSNNNLFNASVAG
                     TISKIAQSEDEDGNVKNLISITTATGDVVTDTVPVGPELVVTEGQAVAIGDALTNNPNV
                     GGFGQKDAEIVLQDSSRVAWLVAFICLVMLAQVMLVLKKKQVEKVQAAEMNF"
     CDS             6196..6972
                     /locus_tag="ctg264_6"
                     /transl_table=11
                     /translation="MIKPRRSVNVDRLLVEIYNSEAEMSESVAKITHQYLQNLLDKQDK
                     VAILLATGNSQIRFLDALIELGEIDWSRIILFHLDEYLGITSDHPGSFRRYLRERVEEK
                     VCPHRFYYITGDTLQPIAECDRYAQLLENQPIDLCCLGIGENGHLAFNDPAVANFQDIS
                     KIKLVKLDNVNRQQQVNTGYFANLVDVPQYAFTVTIPMICSAKKIICLAPTNRKAEVVK
                     TMLTGDITTNCPASILRQQPQATLFLDVNSASLLTY"
     CDS             complement(7022..7723)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 196.3; E-value:
                     1e-59)"
                     /gene_kind="transport"
                     /locus_tag="ctg264_7"
                     /transl_table=11
                     /translation="MIQYLPSPNILEITNLNHYFGHSKLLTQTLFEINLTIKPGEIVIM
                     TGPSGSGKTTLLTLIGGLRSVQEGSLQFNGQELFGASREELVQVRRQIGYIFQAHNLLD
                     FLTAMQNVQMSLELQNDISSWESYIQSETMLNAVKLGDRINYYPSDLSGGQKQRVAIAR
                     ALVSHPKLVLADEPTAALDSKSGRDVVNLMQQLAKEQNCTILIVTHDNRILDIADRIIT
                     MEDGHLMQQLT"
     CDS             complement(7727..8902)
                     /locus_tag="ctg264_8"
                     /transl_table=11
                     /translation="MILNIPLPWLQLVKQKVRFFVALAGIAFISVLMFMQIGFQDALYA
                     SATQVHKHLRGDLFLISSQYKSLTSTQSFPRSRLYQILGFNGTESVEPLYVQFAKLKNP
                     INGRKYPIYILGFDPVKSIFKLPEVDQNFQLLKIPDQVFFDRAARPEFGPIAEYFQKNQ
                     PIGMEIFSYLGTIGYKVKVSGLFTLGPSFGVDGNLIVSSSTFFNIFPEHRSNQIDIGLI
                     HLKPNVNPQAILTTLSNSLPKDVTVMTRQEFIDFEKSYWTLRTPIGFVFNLMVMMGFVV
                     GVIVVYQILYSNISTHIVQFATLKAMGFRNKYLLNVVFQQAVILAILGYIPGFAISLGL
                     YDIAKNATKLPIVMDLNKGLLVFISVIVMCLTSGFFSTNKLRKVDPAEIFN"
     CDS             complement(8978..10126)
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 193.5; E-value:
                     8.5e-59)"
                     /gene_kind="transport"
                     /locus_tag="ctg264_9"
                     /transl_table=11
                     /translation="MLASAGVIATSIISIDSLLHFWKPSKSASQISPILPSLAPTINAV
                     AALGRLEPQGEVIRLSAPNSQTGIRVNQLLVKKGDKIRQGQIVAVLDSYIPNLAVLEKA
                     KRQVEVSQANFEQVKAGAKEGDISAQKATISRLEAELRGSISTQKATISRLEAELKNSE
                     TENTRYQKLYQDGAISASDTDTKKLRRDTVQEQLNEANANLKRTVETLEKQLSESQARL
                     TSIAEIRPTDLQLAQANVKSAIASVQQAQAELNLSSILAPINGQVLKINTWPGEIIGNK
                     GILELGQTQQMYVVAEVYETDIKKVRLGQSVTITGEAFTGTLKGTVTDIGLQVGRQNIF
                     NTNPGSDTDNKIVNVKIRIDNPADNQRVSSLTNLQVQVLIKI"
     CDS             complement(10501..10830)
                     /locus_tag="ctg264_10"
                     /transl_table=11
                     /translation="MRLSELDPLIPLNELREDLLKLPKGYSFYEDELVDFLSRRRWPES
                     NRRIDRTTFWRWRNDNAIEHQKIFSRLDLLKLCQICDHYRVDGTRSEYLAIMRKKKEKE
                     VVLNK"
     CDS             11761..14274
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (52-507). E-value:
                     1.2e-126. Score: 414.7. Matches aSDomain:
                     nrpspksdomains_ctg264_11_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (624-835). E-value: 1.2e-50.
                     Score: 164.3. Matches aSDomain:
                     nrpspksdomains_ctg264_11_PKS_AT.1"
                     /NRPS_PKS="type: PKS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     hglE-KS: hglE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 275.8; E-value:
                     1e-83)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg264_11"
                     /sec_met_domain="PKS_AT (E-value: 2.6e-51, bitscore: 164.3,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="hglE (E-value: 2.4e-225, bitscore: 737.1,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAASKFEVDFAQLQSEISNCEKSVLKMITVKKNMPDTTKMKNEIN
                     AKLRTTNVAIIGMASIFPQAKNLQEYWENIIQKVDCITDVPASRWHIDDYYDPDPKAPD
                     KTYCKRGGFLPDIDFNPMKFGLPPNILEVTDISQLLGLVVAKEAIEDAGYGVSRQFNHE
                     RTGVVLGVAIGRQLAVPLGARLQDPLWKKVLKNSGLSDEDSQKIIEKIKSGYVQWEENA
                     FPGMLANVISGRIANRLDLGGMNCVVDAACASSLGALRMAISELVEHRADMMITGGVDT
                     DNSIFAYMCFSKTPAVSPGDKVKPFDADADGMMLGEGVGMLVLKRLEDAQRDGDRIYAV
                     IKGVGSSSDGKYKSIYAPRPEGQINALHRAYNEAGISPASIGLIEAHGTGTMVGDPTEF
                     TSITTVFGENNPKKQHIALGTVKSQIGHTKAAAGAASLIKAALALHHKVLPPTINVSKP
                     HPKLNIENSPFYLNTETRPWISHPTQPRRAGVSAFGFGGTNYHVVLEEYEHEHHHPYRL
                     HHTPQSLLLFAPTASELLSRCQQIQQQLQIDGKEQHYQQLVTESQIGKIPVNYARVGFV
                     ANDLAQAGELLEIVIKGLKQKPEAESWEHPQGIYYRQAGIDARGKVVALFSGQGSQYLE
                     MGRELVINFPCLRQTYTHMDSLLCEDGLQPLSTVVFPQPIFDQAQKQIQLATLQKTEYA
                     QPAIGVFSAGLYKILQQAGFKPDFVAGHSFGELTALWAAGVLSEEDYLFLVKARGQAMA
                     TPANSDFDAGGMLAVKGNIHQITEVIKNFPLVAVANRNSQHQIVLAGKKKEISQVQDIL
                     KNQGFSTFLLGVSAAFHTPLVSHAQK"
     aSDomain        11917..13281
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg264_11_PKS_KS.1"
                     /evalue="1.20E-126"
                     /label="ctg264_11_PKS_KS.1"
                     /locus_tag="ctg264_11"
                     /protein_end="507"
                     /protein_start="52"
                     /score="414.7"
                     /tool="antismash"
                     /translation="VAIIGMASIFPQAKNLQEYWENIIQKVDCITDVPASRWHIDDYYD
                     PDPKAPDKTYCKRGGFLPDIDFNPMKFGLPPNILEVTDISQLLGLVVAKEAIEDAGYGV
                     SRQFNHERTGVVLGVAIGRQLAVPLGARLQDPLWKKVLKNSGLSDEDSQKIIEKIKSGY
                     VQWEENAFPGMLANVISGRIANRLDLGGMNCVVDAACASSLGALRMAISELVEHRADMM
                     ITGGVDTDNSIFAYMCFSKTPAVSPGDKVKPFDADADGMMLGEGVGMLVLKRLEDAQRD
                     GDRIYAVIKGVGSSSDGKYKSIYAPRPEGQINALHRAYNEAGISPASIGLIEAHGTGTM
                     VGDPTEFTSITTVFGENNPKKQHIALGTVKSQIGHTKAAAGAASLIKAALALHHKVLPP
                     TINVSKPHPKLNIENSPFYLNTETRPWISHPTQPRRAGVSAFGFGGTNYHVVLEEYE"
     aSModule        11917..14265
                     /domains="nrpspksdomains_ctg264_11_PKS_KS.1"
                     /domains="nrpspksdomains_ctg264_11_PKS_AT.1"
                     /incomplete
                     /locus_tags="ctg264_11"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       12676..12714
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg264_11_0001"
                     /evalue="3.90E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="ctg264_11"
                     /protein_end="318"
                     /protein_start="305"
                     /score="10.6"
                     /tool="antismash"
                     /translation="FDADADGMMLGEGV"
     CDS_motif       12910..12954
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg264_11_0002"
                     /evalue="3.00E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ctg264_11"
                     /protein_end="398"
                     /protein_start="383"
                     /score="12.9"
                     /tool="antismash"
                     /translation="IEAHGTGTMVGDPTEF"
     CDS_motif       13015..13059
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg264_11_0003"
                     /evalue="4.00E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="ctg264_11"
                     /protein_end="433"
                     /protein_start="418"
                     /score="10.0"
                     /tool="antismash"
                     /translation="GTVKSQIGHTKAAAGA"
     aSDomain        13633..14265
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg264_11_PKS_AT.1"
                     /evalue="1.20E-50"
                     /label="ctg264_11_PKS_AT.1"
                     /locus_tag="ctg264_11"
                     /protein_end="835"
                     /protein_start="624"
                     /score="164.3"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /specificity="consensus: mal"
                     /tool="antismash"
                     /translation="LFSGQGSQYLEMGRELVINFPCLRQTYTHMDSLLCEDGLQPLSTV
                     VFPQPIFDQAQKQIQLATLQKTEYAQPAIGVFSAGLYKILQQAGFKPDFVAGHSFGELT
                     ALWAAGVLSEEDYLFLVKARGQAMATPANSDFDAGGMLAVKGNIHQITEVIKNFPLVAV
                     ANRNSQHQIVLAGKKKEISQVQDILKNQGFSTFLLGVSAAFHTPLVSHA"
     CDS_motif       13636..13680
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg264_11_0004"
                     /evalue="1.50E-05"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="ctg264_11"
                     /protein_end="640"
                     /protein_start="625"
                     /score="17.5"
                     /tool="antismash"
                     /translation="FSGQGSQYLEMGRELV"
     CDS_motif       13897..14019
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg264_11_0005"
                     /evalue="2.10E-15"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ctg264_11"
                     /protein_end="753"
                     /protein_start="712"
                     /score="48.7"
                     /tool="antismash"
                     /translation="GFKPDFVAGHSFGELTALWAAGVLSEEDYLFLVKARGQAMAT"
ORIGIN
        1 cataggaact gatagcttgt tcaggagcag cagaaccagg aacgtgctgc atagaaccga
       61 atagagaacc tgctacccgt tgagcttcag cggattccgc tagatcaaag atttgttcat
      121 aaatggggtt tccatcacca gcagccgcag cagcgataat tgataatttt ttggctggag
      181 gaactagttc atagtaggtc ttagcacgta ggtcttcttc aaaatctaca gtgataaaga
      241 catcttcaat ccaatcagaa ggataaacgg ggggaatatg caccctagcg gaacgcgcta
      301 atactagcca accaccatta gcggtgcgat aaccgatatc tatcacataa tcacgatcgc
      361 tcacgggaat tggcaagtac cattctctgg ctagttcatc cgcagggtat tcttgaatac
      421 tgtgggggct ttggtattct agatcaatgt cggtaacatc ataaatccgc aatgctaggg
      481 tttgtccacc ttgacgacga attgcttctt tatggtcgtt aggaatatcc caataagtat
      541 aagcccattg agggtcacgg ggtaatagaa caatccgact atcaccataa cctgcaggta
      601 aatccgttag tgcttcatca acatcagcta gagaaccacc agttagatct tcttgaccta
      661 attcaaattt tgctgcttcc actgtttttt gtgcctccaa attaggggat gaactgagcg
      721 agaatttact attttgaacg tcttcaattg atgctaataa ctgcgattta cgcattctgc
      781 tatagcgaga tatggaatac tcactggcaa ctttgcgtaa ttgccttagg gtcatctctt
      841 ctagtggtgg gcgttctttt gccatgaatt tggactccag tagtttacaa ggtaaattat
      901 ttttcccggg ttaaaaagag tttgattaaa tatcatctac ccagattttt ttattactga
      961 ctcctagaca aaacccagtt ttaaatttgt ttactgtctg ttttttttat tgatatctca
     1021 acctctctca attcctactt tgaggattgc gaggggttgt taagtaaata ttaaccagta
     1081 aaactatcta gggatcaagg ggtctaaaga taggttttac tctattttac gtagttatca
     1141 gggttgcggg gatcgttttg tcatgaaatc ttcatataac ggttttgaat agggaatttg
     1201 tgtcaagatt tgatgacatt tatcgtcaga aataagaaat aggaatagat ttaacaacca
     1261 acaactgacc actagaccaa tcataaaaat gtgtgaatta ccgacattcg cagaattagc
     1321 catttacctt ctttatgaat caaatcatag cgaacacgca atgtttcatc agaggacttt
     1381 ttctgctgac tattttgata gaacttggta acttcttgta ctttagcgtc tattgatata
     1441 ttatcttcat ctatgccttt tttagagata gctactattt ctacattatg tttataatga
     1501 cgatagcggt tactttcttg ttcctgctgc gctactgaaa gccattggga taaaacctta
     1561 cccgttaaaa tttcatttaa agcatcaatg tcatgatttg gccctaaagc tgcggttttt
     1621 gctgataacc aagtttcaat tactttcttt gctgtctcct ttgtcagttc tttgtcgctt
     1681 aattcctcct gagtattagg gtcaggaata ggaattggtg gttgactcag ttctattgct
     1741 aactgttgtc cccttaatga tggactggga aagaagatat tttttaccaa gctaaaagtt
     1801 gttgacacta gtagggaaaa aattaatacc cctcccaata aaaagaaaac cagccatact
     1861 aagcgtgtct ttggatctag gcgactgaga aaattagttt gagaccttat aaaccgccgg
     1921 aaaagattat tagcaagggg tttgcgcctt ctacgagggg gctggtggtt tgttgcgggg
     1981 cttggatgac cattgcttgg ctgtggtctt ttgtgggggg ttgttaccgt tggtggtatt
     2041 tgtgatgctt gatttcccac acttctattt cctggttgac gattccagcg gggtatggaa
     2101 tcttgggtag attcagattc aggacgagaa tgggttactg gtaactcagg attagctggt
     2161 tggtgatcat gttcctgttt ttgtgtggtg ttactagtat ggtagtggaa atgatgaaga
     2221 tctgattgga gaaaggattg atgattaatt gcagcccatt cattagtgat ttgggcatca
     2281 gtgggcaaag attctagata agcttgtact tgtctatcag caaagtaatc tcttaaagag
     2341 gcttgctgtt tggccaaatc ccgaaaatgg gggaatactt cttgctgtaa ccattgttca
     2401 ctatataaac acagtccggg taatagatct ggtgaatctt gggatttttc ccgaataaaa
     2461 gctaaggcct catattcttg acttagttct aaaacccggg tagattcttc cgtttgtccc
     2521 ataagcaaag cacaaaggga ttgttccaag tgcacatctt ggcgtttacc taattgcatt
     2581 aacatttgct tggcttggcg aattaaagct ggttggcgtt gagcaaaacc tctggcaatt
     2641 aaggagtata ctgctaaata tatcgcaact ggcgaaggtc gtttactttc taattcaaag
     2701 agcttatgtt gttccgctac tgttaaataa tggcgaattt gttggataaa tcgtaaaaaa
     2761 tcatctatat tcaacccaga ttgatcatta ccagttccat caattccacc acggtcttcc
     2821 aagatactct gtaataattc taacccctgc cgacgtttgg gaatttctat ttgcggtagt
     2881 gccaatagtt ccaaaatgcg ataggggcga agtttgtaaa gatcagcagt catttcggcg
     2941 cggacactgg gaaataatcc ttcccgcgct aatagttctt cacccgtttc taaagatact
     3001 gctgcatttt catagtgacc ttgctgccat tcttcccgtc ctagttctag acaagctagg
     3061 gagacagtga ggataatatc tggtaagtct gggtgatcgg gaatttgtga ccgggtaaca
     3121 gaatgatctg ttttcaggtt aactggacta gatttattaa ccaagtacgg ccgacccagt
     3181 tttaatacta attcatattc tcctagctct tggagaatta acaaagagcc aataaattgc
     3241 tccggggtga tttcaatgct gagactttga gcatcttgat ccttggagtt actatctggt
     3301 agggtttccg gtggaacttg atcagcagtt gtattaggag tataaacgtg agctagataa
     3361 agctgatcat aggacttgcg cttttcggtg tctaataaga ccatataagc ttcttcaatc
     3421 agcctcttac gagaggatat agatgtaatc gaatattccc gtcgtggcaa ttgggcaatg
     3481 cgatcgctgt atgcctgtcg caattgttcc tcattggccg ccaacggtaa tcctagaatt
     3541 cggtaataat cgagcggaat tcgcacagct tacgtcccct gcactgtgtt atcgtagctt
     3601 atcgtaaaaa ttaacataat ttacccggac tgttctaggc ttctaaaacc gtctcataat
     3661 catagcctga ttaataccgt gttgacctag tacaataagt gtaaatagta acggaaatct
     3721 gattttttac cgttaatgtt tttatatctt gagtttcagg tcgctaaatc ggcagttggg
     3781 agtcaggagt aaaatttgat tacctgttac ctattgccga ttgcctaatt cttaaacaat
     3841 ccattctgat gctcgttcac ccaaatccag ggggatgcta actgctttgc caagacgtgg
     3901 acgttcttta gtttcggtaa taaaagtttg tacttgttgt gttcctccta aagcgtttaa
     3961 ataattagca atgctgtcga gatgatcttg gtaatctgtc tcactcaagg ggaaagaaac
     4021 ttgtccaaaa tatttccaca tgatttgtag gaatattttc ccctgggtgc gacgaaactg
     4081 gagatcataa gcttgtcccc atttattaat caacagttga cgtaattccc ttccggtcat
     4141 agcaatttta gtccgttgtc agttgtccat tgtccgttgt taagaagttt cctcctattc
     4201 cctattccct gggcttatct agattttaca tttagttatg atattaagtt ccgtgactcc
     4261 agtatgataa ggatataaag aaatgtaatg ctaacagaaa agatgctcac tatgtcttgc
     4321 aactaagaag tatggcatcg ctgtgagcgt tattgtttcg attcagataa gagttactca
     4381 agtgctggta ctcttatcaa aatgattaat aaattacaca aacagcgcgg agattatggc
     4441 tcaattttct gaatcagcag acgttcccga tatgggtcgt cgtcagttta tgaacctgct
     4501 cacttttggg actgttaccg gagtggcttt gggtgcattg taccctgttg ttaactactt
     4561 tatccctcct gcggccgttg gtgctggtgg cggtacagta gccaaaaacg agttgggtaa
     4621 tgatgttagt gttagtcaat ttctggatgg ccataatgtg ggcgatcgca ctttggtgca
     4681 aggactcaag ggagatccta cgtatattgt agtggaaagt aaagaagcga tcgctgatta
     4741 cgggattaat gctatttgta cccacttagg ttgtgttgtt ccttggaatg tggctgaaaa
     4801 taagtttaaa tgcccttgtc atggttcaca atatgacgct actggtaaag taattcgcgg
     4861 tcctgcaccc aaatccttac ctctggctca tgcaaaagtg acagacgaca aaattctgtt
     4921 aacaccttgg acagaaaccg atttccgcac tggggatgcc gcttggtggg cttaaatagt
     4981 gcaaaagtta ttagtctcaa gtcaacaatc tagggctttt aatcaactct tgactactga
     5041 caactgacca atgacaactg accaataacc actgacaaat gactttatag agatgagaaa
     5101 tgcccttaca cctacgaggt taactcgtac tgctaaagca atgttcaaaa cattgttaat
     5161 agcgatcgct actgttacct ttttcttcac tagcgatata gttgtaccac aaaccgctgc
     5221 cgcctatccc ttctgggctc aggaaaccgc tcctgcaacc ccccgcgagg ctacaggccg
     5281 aattgtttgc gctaactgtc acctagcggc taaacccaca gaattggaag ttcctcaatc
     5341 tgtgctacct gatactgtat ttaaagccgt tgtcaaaatt ccttatgatc ctagtgtgga
     5401 acaagtgggc gctgatggtt ctaaggtggg cttaaatgtt ggtgctgtat taatgttgcc
     5461 cgaaggcttc aagattgccc cagaagaccg tattcctgaa gaaatgaaga aagaagtggg
     5521 tgatatgacc ttcactcctt acaacgatga aacagataat gtttttattg ttggtccatt
     5581 acccggtgag gaatatcaag aaattgtctt cccggttctt tctcctaacc ccgctacaga
     5641 caaaaatatc cactttggca aatactctgt tcatgtaggc ggtaatcgcg gacgtggaca
     5701 agtttacccc acaggtgaaa aaagcaataa taacctattc aacgcttctg ttgccggtac
     5761 aattagcaaa attgctcaat cagaagatga agacggtaat gtgaagaatc tgattagcat
     5821 cacaactgca actggtgatg ttgttactga tacagttcct gtgggacctg aattagttgt
     5881 aactgaagga caagcagtag caattggtga tgctttgact aataacccca atgttggcgg
     5941 ttttggtcaa aaagacgcag aaatcgtttt acaagactct tctcgagttg catggttagt
     6001 tgcttttatc tgtttagtaa tgttggcaca agtaatgcta gttctcaaga agaaacaagt
     6061 agaaaaagtc caagctgcgg aaatgaattt ctaaagcaaa ttctttgcta aattatcagt
     6121 tatttgacag gctttttgcc tgtctttttt tataattagt aattggtgat tgatatgggt
     6181 aattgggagt aacaaatgat aaaacctaga aggtctgtta atgttgatcg tttgttggtg
     6241 gagatttaca attcagaagc ggaaatgtcg gaaagtgtgg ctaaaatcac acatcagtat
     6301 ttacaaaatc tgctcgataa acaggataaa gtggcaattt tattagctac aggtaattcc
     6361 caaattcgat ttttagatgc tttaattgag ttaggggaaa tagattggtc acggataatt
     6421 ttatttcatt tagatgaata tttgggaatt acatcagatc atcctgggag ttttcgtcgt
     6481 tatttacggg aacgggtaga agaaaaggta tgtcctcaca gattttatta tataacaggg
     6541 gatacattac aaccaatagc tgagtgcgat cgctatgctc aacttttaga aaatcaaccg
     6601 atagacttat gttgtttagg tattggagaa aatggacatt tggcatttaa tgatccagca
     6661 gtggcaaatt ttcaggacat ctctaaaatt aaacttgtta aattggataa tgtcaatcgt
     6721 caacaacaag taaatacagg atattttgct aatttagtag atgttcccca atacgcattt
     6781 actgtaacta ttcccatgat ttgcagtgct aaaaaaataa tttgtttagc accaacaaac
     6841 agaaaagctg aggtagttaa aaccatgttg acgggagata ttactactaa ttgtccagct
     6901 tctattttac gtcaacaacc ccaagctact ttatttttag atgttaattc agctagttta
     6961 ttaacttatt aaataactag acataggaag gtatctgact tttttgataa gtcaggtatc
     7021 tctatgtgag ttgttgcatt aaatgaccat cttccatagt aataattctg tcagcaatat
     7081 ctaaaatccg gttatcgtgg gtgacaatta aaatagtaca attttgttct tttgctaatt
     7141 gctgcattaa attaactaca tctcgtcctg atttactatc taaagcagcc gtaggttcat
     7201 cagctaatac taacttagga tgactcacta gagcgcgagc aatagctacc cgttgttttt
     7261 gtcctccaga aagatcagaa ggataataat taattctatc tcctaatttt acagcattga
     7321 gcattgtttc tgattggata taagattccc atgaagaaat atcattttgt aattccaaag
     7381 acatttgaac attttgcata gctgtgagga aatctaataa attatgcgct tgaaaaatat
     7441 agccaatttg acgacgaact tgtactaatt cttcccgact agcgccgaat aattcctgtc
     7501 cattaaattg taaacttccc tcttgtacag aacgtaaacc tccaattaat gttaataaag
     7561 tagtttttcc tgaaccagat ggtccagtca taatcacaat ttctccaggt ttgatagtca
     7621 aattaatctc aaataaagtc tgagtaagta atttactatg accaaagtaa tgattaagat
     7681 ttgtgatttc taaaatatta ggagaaggta aatattggat catgagttaa ttaaatattt
     7741 ccgctggatc taccttacgt agtttattgg tagaaaagaa accagaagtt aagcacataa
     7801 caatcacaga aataaatact aataatccct tatttagatc cataacaatt ggtaatttag
     7861 ttgcattttt agcaatatca tatagtccta aagagatagc aaaaccggga atgtaaccca
     7921 aaatagctaa aattacagct tgttgaaata cgacatttaa aagatattta ttcctaaatc
     7981 ccatagcttt gagtgtagca aattggacaa tatgagttga tatattacta taaaggattt
     8041 gataaacgac aattacaccg acgacaaaac ccatcattac cattaaatta aatacaaatc
     8101 caattggtgt tcttaatgtc caatagcttt tttcaaagtc aataaattct tggcgtgtca
     8161 ttaccgtgac atcctttggt aaactattag ataaagttgt gagaattgct tgggggttaa
     8221 cattaggttt tagatgaatt aagcctatat ctatttgatt tgatctatgt tctggaaaga
     8281 tattaaaaaa agtagaagaa ctaactatta aattaccatc cacaccaaag gaaggtccaa
     8341 gagtaaataa accactaact ttaaccttat aaccaatagt tcccaaataa ctaaatattt
     8401 ccatacctat aggttgattt ttttgaaaat attcagcaat tggtccaaat tctggccggg
     8461 ctgcgcggtc aaaaaatact tgatcaggaa tttttagtaa ttgaaaattt tgatctactt
     8521 ctggtaattt aaagatagat tttaccggat caaatcctag aatgtaaata ggatatttgc
     8581 ggccattaat gggatttttg agtttagcaa attggacata taaaggttca acagattctg
     8641 tgccgttaaa acctaatatt tgatataaac gactgcgagg aaagctttga gtagaagtta
     8701 aagatttgta ttgagagcta attaaaaaca aatcacctcg caggtgttta tggacttgag
     8761 tagcactagc ataaagagca tcttgaaacc caatttgcat aaacattaaa acagaaataa
     8821 aagcaatacc agctaatgct acaaaaaagc gtactttttg ttttaccaat tgtagccaag
     8881 gcaaaggtat atttaaaatc atgtttttcc cttgtggtta tataagcact aaatttttta
     8941 aatacatctt attaatcatc gaaattatag ttcagtttta tatcttaata agtacctgta
     9001 cctgtaaatt tgttaagctt gaaactcgtt gattatctgc ggggttatca atgcgaattt
     9061 ttacattaac tattttgtta tctgtgtctg aaccaggatt agtattgaag atgttttgtc
     9121 taccaacttg taaaccaata tctgtaactg tcccttttaa tgttcctgta aaagcttcac
     9181 cagtgatagt tactgattga cctaaacgaa cttttttaat atcagtttca tagacttctg
     9241 caactacata catttgttga gtttgtccta attctaatat gcccttattg ccaattattt
     9301 ctcctggcca agtattaatt tttagcactt gaccattaat aggtgcaagg atagaactta
     9361 aatttagttc tgcttgagct tgttgaacag atgctatggc acttttgaca tttgcttgtg
     9421 ctagttgcaa atctgtagga cgaatttctg caatactagt aagtctagct tgagactcac
     9481 ttaactgttt ttctaaagtt tctacagttc gttttagatt agcattagct tcattaagtt
     9541 gttcttgaac agtatccctg cgtaattttt tagtatctgt atcagaagca gaaatagcac
     9601 catcttgata taatttctga tatcgtgtat tttcggtttc tgaatttttt agttcagctt
     9661 ctaaacgaga aattgtagct ttttgagtag aaattgaccc tcgtaattca gcttctaaac
     9721 gagaaattgt ggctttttga gccgaaatat caccttcttt cgcacctgct tttacttgct
     9781 caaaattcgc ttgactgact tctacttgtc gttttgcttt ttctaaaact gcaagattag
     9841 ggatataact atcaagaact gctactattt gtccttgacg aattttgtct ccttttttca
     9901 ccaaaagttg attaactctg attcctgttt gcgaattagg tgcagaaaga cgaatcacct
     9961 ctccttgagg ttctaaacgt cctaaagccg caacagcatt aattgtaggc gctaaactgg
    10021 ggagaatagg agatatttga gaggctgatt tagaaggttt ccaaaaatgt aaaaggctat
    10081 caatagatat tatactagtc gctataaccc cagcacttgc taacattatc ggcaataaac
    10141 ttataggttt tattaatgag tgcttttctt tgtgtaccat aattttgtct tttaaattag
    10201 gaaatatgac aatataactg actctaaata cgagacagaa aagccattac acttgatagc
    10261 atctcttgat aaccttatct ctgatataat aaatatccaa tatccaaaaa aatactattt
    10321 atcaaaaatt ttgttagttt tgaaaacttg attattcaaa cctacactta aatttctgat
    10381 gacaaaaatt atttactgag gttaattaac aggaaattac ataaaatgct caaatactaa
    10441 aattttgata ggtaattggc aattagttaa tgactattac cgattaccaa tatcaaaaaa
    10501 ttatttattt agtacaacct ctttctcttt cttcttccgc ataattgcca agtattcgct
    10561 gcgggttccg tctactcggt aatgatcaca aatttggcaa agtttgagaa ggtctaagcg
    10621 actaaatatt ttttgatgtt caatagcgtt atcattacgc caccgccaga atgttgttct
    10681 atcaatgcgg cgattgcttt caggccatct tctccgtgat agaaaatcta ctaattcatc
    10741 ttcataaaat gaataacctt ttggtaattt gaggaggtct tctcgtaact cattcagcgg
    10801 gatgagtgga tctaattcag atagtctcat gccagcaatt ccttgtagtt tttgtaattc
    10861 caatattgca gaagccagat aatgcaataa cgtttaattg actaatttta cgctcaatga
    10921 ctgttttaaa ttttcagtct aaatttcccc tgatttaata atttagatta aacttatttt
    10981 ttaggaattt caacctatat gcaacgaatt gtttcataaa accttattta tggtactatc
    11041 ttggatttgc aaaacttgta agcatcaaat tatcaattcc ttaaatagat caagaattac
    11101 taattttgta ttatctcaaa cttaggacat aaattgataa aaaatatatt tttaattcct
    11161 tagatatatt taatagtgac taattttaca aaagcaaaaa aatatttctg gagatagatg
    11221 caaaaattaa atatttagaa ttagaaacta atgaacaacc attatatatt taagatttta
    11281 tttgtattca gaggattttc tattcttggc tattgtaaaa taaagttttc aataagtgga
    11341 aattaagaat atgcaatctc tatacaactt ttgtcaaaat ggctaaaact tagataataa
    11401 ttagtgtatt ggacaaggta agatatttat ttgataactc cagcaatttt acatttgcaa
    11461 gattgttata aaattggatg tgagttgctt atgagttgcc atagggttgt cattagacta
    11521 ggattaatat aggcggaaat taatttatag gctacaggat taatcagact atttcatatt
    11581 tgaccgccac agtattcatt aataattcat gccaaaaaaa gatttcaata ccattaagga
    11641 tgaaaattaa aaatttactt aggtatactc taagtaaaag tcatattttc ggaaattaac
    11701 tgaattaaaa aatctcattt caacttgcat attgcccgat caaaaaagtg aaatatgatc
    11761 atggctgctt ccaaatttga agttgatttt gcacagttac aatctgaaat tagtaactgc
    11821 gaaaagtccg tactcaagat gataacggtg aaaaaaaata tgcccgatac cacaaagatg
    11881 aaaaatgaaa ttaatgccaa actgcgaaca actaatgtag caattattgg tatggcttct
    11941 atctttcctc aggcgaagaa tttacaggaa tactgggaaa atattattca gaaagtggat
    12001 tgtattactg atgttcctgc ttcccgctgg catatagatg attattatga tcctgatcct
    12061 aaagcaccag ataaaaccta ttgtaaacga ggaggttttt taccagatat tgattttaat
    12121 cccatgaaat ttggcttacc tcctaatatt ttggaggtga cagatatttc tcaattactg
    12181 ggtttagtag tagcaaaaga ggcgatagaa gatgctggtt atggtgtatc tcgccaattt
    12241 aatcacgaac gaacaggggt agtattagga gtagcaattg gtagacaatt ggctgttcct
    12301 ttgggtgcaa gattgcaaga tcctctttgg aaaaaagttt tgaaaaatag tggtttatca
    12361 gatgaagata gccaaaaaat tattgaaaaa atcaaaagtg gatatgtgca atgggaagaa
    12421 aacgccttcc ccggaatgtt agctaatgta atttctggac gtatcgctaa tcgcctagat
    12481 ttaggcggaa tgaattgcgt agtagatgca gcttgtgcaa gttctttagg cgcactgaga
    12541 atggctatta gcgagttagt ggaacatcgc gccgacatga tgataactgg tggtgtggat
    12601 acggataact caattttcgc ctatatgtgc ttcagtaaaa ccccggcggt ttctccaggg
    12661 gataaggtga aaccctttga tgctgatgct gacgggatga tgttaggtga aggcgtggga
    12721 atgctggtac taaaacgatt agaagacgct caacgagatg gcgatcgcat ttatgcagtc
    12781 atcaaaggtg ttggcagttc tagcgacggt aagtataaaa gtatctatgc acctcgtccc
    12841 gaaggacaaa taaatgcttt acatcgtgca tataatgaag caggaatatc acctgccagt
    12901 ataggtttga ttgaagccca tggtacagga acgatggtag gagatcctac agaatttacg
    12961 tctattacca ccgtttttgg cgaaaataac ccaaaaaaac agcatattgc tttgggaact
    13021 gttaaatccc aaattggaca cactaaagcg gctgctggtg ctgctagtct aattaaagcg
    13081 gctttagcgt tacatcacaa agtcttaccg ccgacaatca atgtcagtaa accccatcct
    13141 aaactgaata ttgagaactc accattttac ttaaatacgg aaactagacc ctggataagt
    13201 catcccactc aaccgagaag ggcgggagtc agtgcctttg gctttggtgg tacaaattat
    13261 cacgttgttt tggaagaata tgaacatgaa catcatcacc cgtaccgttt acaccatact
    13321 ccacaatcgt tgctgctatt tgctcctacg gcttcagagt tgttatctcg ttgtcaacaa
    13381 atccagcaac aattacagat tgatggtaaa gaacaacact atcaacaatt agttactgag
    13441 tctcaaattg gcaaaattcc cgttaattat gccagagttg gctttgtagc gaatgattta
    13501 gcccaagctg gggaattgct ggaaattgtg attaaagggc tgaaacagaa gcctgaagcc
    13561 gaatcatggg aacatcctca agggatttac taccgtcaag cagggataga cgcaaggggt
    13621 aaagtggtgg ctttgttttc tggacaaggt tcacaatact tagaaatggg acgagagtta
    13681 gtaataaatt ttccctgttt gcgccaaacc tatacgcaca tggatagcct attgtgtgaa
    13741 gatgggttac aacccttatc aaccgtagta ttcccccagc cgatttttga tcaagcacaa
    13801 aagcaaattc agttagcaac attgcagaaa actgaatatg cacaaccagc aattggtgta
    13861 tttagtgcgg gcttatataa aatattgcaa caagctggtt ttaaacccga ttttgtcgct
    13921 ggtcatagtt ttggtgaatt aacggctttg tgggctgcgg gtgtattaag tgaagaggat
    13981 tatttgttct tagtaaaagc tagaggacaa gccatggcta cacctgcaaa ttcagatttt
    14041 gatgcagggg gaatgttagc cgtcaaaggg aatattcacc aaataacgga agtaattaaa
    14101 aactttcctt tggtagcagt tgctaataga aattctcagc atcaaatagt attagctggg
    14161 aagaaaaagg aaattagtca agttcaagat attctcaaaa atcaaggatt ttctactttt
    14221 ttattaggag tttccgcagc atttcataca ccattagtat ctcatgctca aaaa
//
