LOCUS       c00272_3300013..        8600 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300013004.a:Ga0164293_10008586.
ACCESSION   c00272_3300013..
VERSION     c00272_3300013..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-24 12:20:15
            Original ID  :: 3300013004.a:Ga0164293_10008586
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8600
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8600
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4650:8599]"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4651..8599
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..8600
                     /SMILES="N1C(CCC1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8600
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             3..2156
                     /locus_tag="ctg272_1"
                     /transl_table=11
                     /translation="TVLPSRIPQLLLNGSSGIAVGMATNIPPHNLGELIDGLVALIHNP
                     EITDIQLMQYIHGPDFPTGAQILGVSGIKEAYTTGRGSITMRGVANIETIAQRNRPERE
                     AIIITELPYQTNKAALIEKIAELVNDKRIDGIADIRDESDRDGMRIVIELKRDAYPRVV
                     LNNLYKQTPLQANFGANMLALVNSEPQTLNLKRFLSVFLDFRIFSIERRTRYELRKAEE
                     RDHLLQGLLIALSQLDAIIVLIRHAPDAPTAKGELINTYGLSEVQADAILQMQLRRLTA
                     LEADKIRLEHEDLQVKITDLLDILAKRERVLEIIQTEISQIKTSFATPRRTVITHGEGD
                     IDDIDLIANEKAIILVTEQGYIKRMPVNTFESQNRATRGKAGAKVKDDDTIEHFLTCCD
                     HDSILFFSDRGVVYCLRAYQIPVGSRTSRGTPIVQMLPIPKEEKITSIVPVDEFSSEEY
                     LVMLTKGGNIKKTVLEAFSHIRANGLIAISLEEGDQLRWVRRARVEDSIIIGSRQGMAI
                     HFRCTHDQLRPLGRATRGVKSMKLKDKDELIGMDILPAAILDTLDTDTEAEIEETAEIE
                     ETVEITEITEIENTEETPETTNTNSTGPWVLVITVGGYGKRVPVSQFRLQNRAGQGLMA
                     TKFKTRKTKDKLATLRIVNNDDEIMMATNRGIIIRQAVNAISIQSRSATGVKVQRLDED
                     DAITGVAIVPPDTGDNGELEEAE"
     CDS             2524..3132
                     /locus_tag="ctg272_2"
                     /transl_table=11
                     /translation="MFKFQIEFKYPIPISKTLTLETLGPSGTSSEAALKYLISQIEQEE
                     INVLVKLFDSFIDLQQALKNEQVDLALVPHAYEKINEFYMQPKFDLGFIFVHPTPVYGL
                     AKRKDQEFKVIGSRIVTHPAPLPLLSELLPPQYSPQEMTVELVNSTSVAAKQVHQGLAD
                     LAITNEKAREYYDLEFVSIHGTIPMSWSVFYKKPSVAYV"
     CDS             3125..3760
                     /locus_tag="ctg272_3"
                     /transl_table=11
                     /translation="MSKFFPSHQNIKVSNIDIVAFQCQDIVFQFAYIAPGACFPLHQHP
                     ESQMGMVISGNLEMNVNGKKEILKPLQQVYSAGSEVPHGSVNYSDESIFCFDVKGLTNL
                     STDEAVFIDLKPTSDQITNFPSHIAVGSWFTTIITQIPPGEKTSNQQSDSEEIGVIIDG
                     KMMVNIGGEQQEIKRGEIYYAPADVIHSGYNSASETVTLIKIVLPHHS"
     CDS             3792..4592
                     /NRPS_PKS="Domain: PKS_KR (8-126). E-value: 2e-10. Score:
                     32.6. Matches aSDomain: nrpspksdomains_ctg272_4_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     189.6; E-value: 1.1e-57)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg272_4"
                     /transl_table=11
                     /translation="MDLGLTGKVALITGSSAGIGLAVAQILAQEGCKLIICGRNFEKIQ
                     QIEKLLSREKENLEILALSADVHKASDSENLVNTALDKFGKIDILINNSEGASFASDAV
                     ETLSDDDWRLVFEAKLMGYIRMTNLVLPGMKNHQWGRIINIVGTSGKEPSPRLIKSGVA
                     NAALMNFTKSVSTQTAKFNVLITTVNPGLIDTPRHRQYLEIAAQEENQSVDVIKSRIAG
                     KIPAGRLGLSDEVANLVVFLASECSSYITGITIPIDGGLSVSAF"
     aSDomain        3816..4169
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg272_4_PKS_KR.1"
                     /evalue="2.00E-10"
                     /label="ctg272_4_PKS_KR.1"
                     /locus_tag="ctg272_4"
                     /protein_end="126"
                     /protein_start="8"
                     /score="32.6"
                     /specificity="KR stereochemistry: C1"
                     /specificity="KR activity: inactive"
                     /tool="antismash"
                     /translation="VALITGSSAGIGLAVAQILAQEGCKLIICGRNFEKIQQIEKLLSR
                     EKENLEILALSADVHKASDSENLVNTALDKFGKIDILINNSEGASFASDAVETLSDDDW
                     RLVFEAKLMGYIRMT"
     aSModule        3816..4169
                     /domains="nrpspksdomains_ctg272_4_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg272_4"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       3822..3911
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_4_0001"
                     /evalue="7.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg272_4"
                     /protein_end="40"
                     /protein_start="10"
                     /score="15.5"
                     /tool="antismash"
                     /translation="LITGSSAGIGLAVAQILAQEGCKLIICGRNF"
     CDS             4651..7938
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (8-38). E-value: 4.8e-19.
                     Score: 59.1. Matches aSDomain:
                     nrpspksdomains_ctg272_5_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (15-316). E-value:
                     2e-114. Score: 373.5. Matches aSDomain:
                     nrpspksdomains_ctg272_5_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (481-884). E-value: 1.1e-96.
                     Score: 315.6. Matches aSDomain:
                     nrpspksdomains_ctg272_5_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (995-1062). E-value: 3e-29. Score:
                     92.8. Matches aSDomain: nrpspksdomains_ctg272_5_PCP.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     360.5; E-value: 2.5e-109)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg272_5"
                     /sec_met_domain="Condensation (E-value: 2.2e-76, bitscore:
                     245.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 9.5e-104, bitscore:
                     335.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4e-19, bitscore:
                     57.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTMQNSGNKTNKNIEAIYPLSSMQQGMLFHSLYNPESKAYLAQV
                     QISLQGNLDILSLEKAWCKVVERHPALRTVFVWKNPKQPLQIVQKQVNVPWVNLDWSSL
                     SSDVQQEQLDTFCQSDQDEYFALDKAPLTRFTLISMGNKSYELMWSSHHILADGWSLSV
                     IMAEVWQFYIAINKGETLYLSPTRPYRDYIGWLQQQDIKQAEIYWRKNLQGFTATTPLQ
                     VDNLHRKKDISREYNHKYFSFSAEETASLKNLAQENYLTLFTLIQAAWGILLSRYSGEA
                     DVVFGATISGRPPALSGVELMVGLFVNTLPVRVKIPEDMGILPWLKQLQQEQIEREEYG
                     HTPLVEIQGWSDIPRGQSLFESFVVFNNLPLGQELGKADHDLQITKTKNTGHADYPLTL
                     IVTPEKELKLNLIYAGDRFDHGTIERMAGHLQTLLLGIVANPQSLPGKLPLLTPQEEKF
                     LLVDSNQTAAENLLQENIHELVTKWSETTPDAVALVFADQKLTYRELNNRANQLAHYLQ
                     KLGVGADIPVGLCLERGLEVAIAILATLKAGGVCVPLDPNYPPERLGLILADTQVPVLI
                     TQSNLQALLQCDFPHHRLILDQEWTQINLENKTNPSTQITSENLAYIIYSSGSTGKPKG
                     IETPHYCLTNLLAHHLTKMACGVGVLQFASLGFDVNFHELSVALGTGGTLYMIPEDTRL
                     DLEKLIQLLVSNSIQKVILNVSVLQELAEFCRQQPELLKNNLREVSATGEQLQITQPII
                     DLFKQLKNCCLYNYYGPAEANLVTTYAFSENPEQWPVYAPIGKAAVNVKVYILDKHFQP
                     VPVGIVGELYVSGYGLARGYFQRPELTKEKFIPNPFDKSPYHRLYKTGDLARYLPDGNI
                     EFLGRIDDLVKIRGYQIDLCEVEAILSKYPRISQAVTTTHGENAKEKFLVAYFIPVINE
                     TVNASELRKYLAAQLPDYMIPSVFVQMDSFPLNPNGKVNRKVLPIPTNERPELNQIYIA
                     PQTPIQEILAEIWAEVLGVKQVGIDDNFFQLGGHSLKAIQLIGKIRQTLELDITIRHLF
                     TSPSVKELATALGELAGGEDIINEIAKTIQEIAQLSPEQLQAMLAQQ"
     aSDomain        4675..4764
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg272_5_NRPS-COM_Nterm.1"
                     /evalue="4.80E-19"
                     /label="ctg272_5_NRPS-COM_Nterm.1"
                     /locus_tag="ctg272_5"
                     /protein_end="38"
                     /protein_start="8"
                     /score="59.1"
                     /tool="antismash"
                     /translation="NKTNKNIEAIYPLSSMQQGMLFHSLYNPESK"
     aSDomain        4696..5598
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg272_5_Condensation_DCL.1"
                     /domain_subtype="Condensation_DCL"
                     /evalue="2.00E-114"
                     /label="ctg272_5_Condensation_DCL.1"
                     /locus_tag="ctg272_5"
                     /protein_end="316"
                     /protein_start="15"
                     /score="373.5"
                     /tool="antismash"
                     /translation="EAIYPLSSMQQGMLFHSLYNPESKAYLAQVQISLQGNLDILSLEK
                     AWCKVVERHPALRTVFVWKNPKQPLQIVQKQVNVPWVNLDWSSLSSDVQQEQLDTFCQS
                     DQDEYFALDKAPLTRFTLISMGNKSYELMWSSHHILADGWSLSVIMAEVWQFYIAINKG
                     ETLYLSPTRPYRDYIGWLQQQDIKQAEIYWRKNLQGFTATTPLQVDNLHRKKDISREYN
                     HKYFSFSAEETASLKNLAQENYLTLFTLIQAAWGILLSRYSGEADVVFGATISGRPPAL
                     SGVELMVGLFVNTLPVRVKIP"
     aSModule        4696..7836
                     /complete
                     /domains="nrpspksdomains_ctg272_5_Condensation_DCL.1"
                     /domains="nrpspksdomains_ctg272_5_AMP-binding.1"
                     /domains="nrpspksdomains_ctg272_5_PCP.1"
                     /locus_tags="ctg272_5"
                     /monomer_pairings="pro -> pro"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       4705..4746
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0001"
                     /evalue="4.30E-05"
                     /label="C1_DCL_004-017"
                     /locus_tag="ctg272_5"
                     /protein_end="32"
                     /protein_start="18"
                     /score="15.4"
                     /tool="antismash"
                     /translation="YPLSSMQQGMLFHSL"
     CDS_motif       4768..4884
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0002"
                     /evalue="1.20E-13"
                     /label="C2_DCL_024-062"
                     /locus_tag="ctg272_5"
                     /protein_end="78"
                     /protein_start="39"
                     /score="43.3"
                     /tool="antismash"
                     /translation="AYLAQVQISLQGNLDILSLEKAWCKVVERHPALRTVFVWK"
     CDS_motif       5104..5166
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0003"
                     /evalue="1.00E-09"
                     /label="C3_DCL_135-156"
                     /locus_tag="ctg272_5"
                     /protein_end="172"
                     /protein_start="151"
                     /score="30.8"
                     /tool="antismash"
                     /translation="HHILADGWSLSVIMAEVWQFYI"
     CDS_motif       5212..5250
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0004"
                     /evalue="4.40E-04"
                     /label="C4_DCL_171-183"
                     /locus_tag="ctg272_5"
                     /protein_end="200"
                     /protein_start="187"
                     /score="12.7"
                     /tool="antismash"
                     /translation="PYRDYIGWLQQQDI"
     CDS_motif       5494..5589
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0005"
                     /evalue="8.50E-19"
                     /label="C5_DCL_263-294"
                     /locus_tag="ctg272_5"
                     /protein_end="313"
                     /protein_start="281"
                     /score="60.0"
                     /tool="antismash"
                     /translation="DVVFGATISGRPPALSGVELMVGLFVNTLPVRV"
     CDS_motif       5638..5760
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0006"
                     /evalue="5.20E-18"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="ctg272_5"
                     /protein_end="370"
                     /protein_start="329"
                     /score="57.5"
                     /tool="antismash"
                     /translation="QQEQIEREEYGHTPLVEIQGWSDIPRGQSLFESFVVFNNLPL"
     aSDomain        6094..7302
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg272_5_AMP-binding.1"
                     /evalue="1.10E-96"
                     /label="ctg272_5_AMP-binding.1"
                     /locus_tag="ctg272_5"
                     /protein_end="884"
                     /protein_start="481"
                     /score="315.6"
                     /specificity="consensus: pro"
                     /tool="antismash"
                     /translation="KWSETTPDAVALVFADQKLTYRELNNRANQLAHYLQKLGVGADIP
                     VGLCLERGLEVAIAILATLKAGGVCVPLDPNYPPERLGLILADTQVPVLITQSNLQALL
                     QCDFPHHRLILDQEWTQINLENKTNPSTQITSENLAYIIYSSGSTGKPKGIETPHYCLT
                     NLLAHHLTKMACGVGVLQFASLGFDVNFHELSVALGTGGTLYMIPEDTRLDLEKLIQLL
                     VSNSIQKVILNVSVLQELAEFCRQQPELLKNNLREVSATGEQLQITQPIIDLFKQLKNC
                     CLYNYYGPAEANLVTTYAFSENPEQWPVYAPIGKAAVNVKVYILDKHFQPVPVGIVGEL
                     YVSGYGLARGYFQRPELTKEKFIPNPFDKSPYHRLYKTGDLARYLPDGNIEFLGRIDDL
                     VKIRG"
     CDS_motif       6274..6315
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0007"
                     /evalue="3.00E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg272_5"
                     /protein_end="555"
                     /protein_start="541"
                     /score="14.2"
                     /tool="antismash"
                     /translation="LATLKAGGVCVPLDP"
     CDS_motif       6511..6570
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0008"
                     /evalue="1.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg272_5"
                     /protein_end="640"
                     /protein_start="620"
                     /score="24.1"
                     /tool="antismash"
                     /translation="AYIIYSSGSTGKPKGIETPHY"
     CDS_motif       7090..7179
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0009"
                     /evalue="1.30E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg272_5"
                     /protein_end="843"
                     /protein_start="813"
                     /score="49.5"
                     /tool="antismash"
                     /translation="PVGIVGELYVSGYGLARGYFQRPELTKEKFI"
     CDS_motif       7267..7332
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_5_0010"
                     /evalue="1.00E-08"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg272_5"
                     /protein_end="894"
                     /protein_start="872"
                     /score="27.4"
                     /tool="antismash"
                     /translation="FLGRIDDLVKIRGYQIDLCEVEA"
     aSDomain        7636..7836
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg272_5_PCP.1"
                     /evalue="3.00E-29"
                     /label="ctg272_5_PCP.1"
                     /locus_tag="ctg272_5"
                     /protein_end="1062"
                     /protein_start="995"
                     /score="92.8"
                     /tool="antismash"
                     /translation="EILAEIWAEVLGVKQVGIDDNFFQLGGHSLKAIQLIGKIRQTLEL
                     DITIRHLFTSPSVKELATALGEL"
     CDS             7997..8599
                     /NRPS_PKS="Domain: Condensation_LCL (73-200). E-value:
                     5.3e-36. Score: 115.9. Matches aSDomain:
                     nrpspksdomains_ctg272_6_Condensation_LCL.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg272_6"
                     /sec_met_domain="Condensation (E-value: 4.6e-31, bitscore:
                     96.6, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTINFLSQLRSLEITISLEGEELKIKAPKGVITPSLKAEIVQRK
                     PEIIAVLQEAKTSTQDVFVPIASVDRTGMLPLSYNQSSMWFIHQLDQDNTAYNESLQLK
                     IKGQLKITILEQSIQEIIRRHESLRTAFPAIDGNPYQKINSHFTFHLPIIDLQTYLETE
                     ISSYITREVRQSFNLENGDLWRFKLLRTGADEYILLII"
     aSDomain        8216..8596
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg272_6_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="5.30E-36"
                     /label="ctg272_6_Condensation_LCL.1"
                     /locus_tag="ctg272_6"
                     /protein_end="200"
                     /protein_start="73"
                     /score="115.9"
                     /tool="antismash"
                     /translation="MLPLSYNQSSMWFIHQLDQDNTAYNESLQLKIKGQLKITILEQSI
                     QEIIRRHESLRTAFPAIDGNPYQKINSHFTFHLPIIDLQTYLETEISSYITREVRQSFN
                     LENGDLWRFKLLRTGADEYILLII"
     aSModule        8216..8596
                     /domains="nrpspksdomains_ctg272_6_Condensation_LCL.1"
                     /incomplete
                     /locus_tags="ctg272_6"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       8279..8395
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg272_6_0001"
                     /evalue="7.60E-17"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg272_6"
                     /protein_end="133"
                     /protein_start="94"
                     /score="53.7"
                     /tool="antismash"
                     /translation="TAYNESLQLKIKGQLKITILEQSIQEIIRRHESLRTAFPA"
ORIGIN
        1 ccacggtttt accctcccgc attccccaac tcctgctcaa tggttcttcg ggaattgctg
       61 tgggaatggc cacaaatatt cctccgcaca atttgggaga attgattgat gggttagtag
      121 cactaattca caatcccgaa ataactgaca ttcagttaat gcagtatatt cacggtcccg
      181 atttccccac cggagcgcag atattaggag tcagtggtat caaagaagct tacaccactg
      241 ggcgcggttc aattaccatg cgcggtgtag ccaatattga aaccattgct caacgcaacc
      301 gtccagaacg ggaggcaatt attattaccg agttgcctta ccaaaccaac aaagcggcct
      361 taattgaaaa aattgccgag ttggtcaatg ataaacgcat tgatggtatt gcagatatcc
      421 gggacgagag cgatcgggac gggatgagaa ttgtgataga attaaaacgt gatgcctatc
      481 cccgcgtcgt tttaaacaac ctttataaac aaacccctct tcaagctaat tttggcgcaa
      541 atatgttggc attagtcaac agtgaacccc aaaccctaaa tctcaaaaga tttctcagcg
      601 ttttcttgga tttccgtatt ttctccatag aacgccgtac ccgctacgaa ctacggaaag
      661 cagaagaacg agatcacctt ctgcaagggt tattaattgc tctctctcaa ttagatgcaa
      721 ttattgtttt aattcgtcat gcaccggacg cacctacagc caaaggtgag ttaattaaca
      781 cttacggact ctccgaagtc caagcagacg caattttaca aatgcaactg cggcggttaa
      841 cggctctaga agctgataaa attcgtctcg aacacgaaga cctccaagtt aaaattaccg
      901 acttactcga tattttagct aaacgggaac gggtactaga aatcattcaa actgaaatca
      961 gtcaaatcaa aaccagtttt gctacacccc gacggacagt aattacccat ggggaaggag
     1021 acatagatga tattgactta attgccaatg aaaaagcaat tattctggtg acagaacaag
     1081 gttacatcaa acggatgccc gttaatacct ttgaatctca aaaccgcgct accagaggta
     1141 aagccggtgc caaggttaaa gatgatgata ccattgagca tttcttaact tgctgtgatc
     1201 atgatagtat cttattcttt agcgatcgcg gtgttgttta ctgcctaaga gcatatcaaa
     1261 tacccgtagg ttcgcgcacc agtcggggga cacccatagt ccaaatgtta cccattccca
     1321 aagaagagaa aattacctcc attgtccccg tagacgaatt tagcagcgaa gaatatctcg
     1381 tcatgcttac taaaggcggt aacattaaaa aaaccgtcct agaggcattt agccatattc
     1441 gcgctaatgg attaattgct atatccttag aagaaggcga ccaactgcgc tgggtgagga
     1501 gggctagagt agaagatagc ataatcatcg gttcacgtca aggtatggcc attcacttcc
     1561 gctgtactca cgaccaactg cgtcccctgg gtagagccac tcgtggtgta aaatccatga
     1621 aactcaagga taaagatgaa ctcatcggta tggatatcct accagcggct attctcgaca
     1681 cattagatac agatacggaa gcggaaatag aagaaaccgc agaaatagaa gaaaccgtag
     1741 aaattaccga aattaccgaa attgaaaata ctgaagaaac cccagaaacc actaacacca
     1801 atagtacggg accctgggta ttagtcatta ccgttggcgg ttatggtaag cgtgtgcctg
     1861 tttctcaatt ccgactgcaa aaccgcgctg gtcaaggttt aatggcgact aaattcaaaa
     1921 cccgcaaaac taaagataaa ctggccacct taaggattgt gaacaatgat gatgaaatta
     1981 tgatggccac caatcgcggt ataattattc gtcaagcggt gaatgcaatt tctattcagt
     2041 caaggtcagc tacgggggtg aaagtgcaac gtttagacga agatgatgct attactggag
     2101 ttgctattgt tccccctgat acgggtgata atggagaact agaagaggca gaatagctaa
     2161 ttagtaagat ctctgacttc ttaaagaagt cggggattta ttttataagt ataaattgca
     2221 gcgtaatttt tatatttttt actcgtggtg cgatcgccaa aaatttttct tttatttact
     2281 tgacaaatat agttaactag tagtatcact taaagggtaa gcaaataaaa taagtttgca
     2341 agctaaaaat taaagaacta tttaaaatta gggattaagg atagacgagc taaaattcat
     2401 taaagagcat atttaagatc aataggcctc tctaaaaaag aatataaacc cattttatct
     2461 cttttagttt agctttaatc catagggcaa gtacacaaat ttaactcagt tcagaaataa
     2521 tttatgttca agtttcaaat tgaatttaaa taccctatcc ctatatccaa gactttaact
     2581 ttagagacat taggacctag cggcactagc agtgaagcgg cactaaaata tctaatcagc
     2641 caaattgaac aagaggaaat taatgtttta gtgaaattat ttgatagttt tatagaccta
     2701 cagcaagcgt taaaaaacga gcaagtagat ttagctttag tacctcacgc atacgaaaaa
     2761 attaacgaat tttatatgca gcctaaattt gatttaggtt ttatatttgt ccacccaact
     2821 cctgtctacg gattagccaa aagaaaagat caagaattta aagttatcgg tagtaggatt
     2881 gttacccatc ctgcaccatt accgctgtta tcggaacttt taccaccaca atatagtcct
     2941 caagaaatga cagtagaatt agtcaactct accagtgtgg cagctaaaca agtacatcaa
     3001 ggtttagctg atttagccat tactaatgaa aaagcaagag aatattatga tttggaattt
     3061 gtttcaattc atggaacaat acccatgagt tggtcagtct tttacaaaaa gcctagtgta
     3121 gcctatgtct aaattttttc cctctcatca aaatatcaaa gttagtaata tagatatagt
     3181 ggcttttcaa tgtcaagata ttgtttttca atttgcttac attgcccctg gagcttgttt
     3241 tccactacat caacatcctg aaagtcaaat ggggatggta atttctggta atttagagat
     3301 gaatgtgaat ggtaagaaag aaattttaaa accgttacaa caagtttaca gtgctggatc
     3361 tgaagttccc catggttcag taaattattc agatgaatcc atattctgtt ttgatgtgaa
     3421 aggactcact aatttatcaa ctgatgaagc agtttttata gacctaaaac ccacttcaga
     3481 tcaaattaca aatttcccca gccatatcgc tgtcggctct tggtttacaa ccattattac
     3541 ccaaattcct ccaggagaaa aaacctccaa ccagcaatct gacagtgagg aaataggggt
     3601 gattattgat ggtaaaatga tggttaatat aggtggagaa caacaggaga taaaaagagg
     3661 ggaaatttat tatgctcctg ctgatgtaat tcattcaggt tataattcag catcagaaac
     3721 agtgacatta ataaaaattg tgttgccaca tcattcttaa ataattagtt attactagag
     3781 gtatattttt gatggattta ggattaacag gaaaagtggc tttaattaca ggatctagtg
     3841 ctggaattgg tcttgcagtt gcccaaatct tagcacagga aggatgtaaa ttaattattt
     3901 gtggacgcaa ttttgagaaa attcaacaga ttgaaaagct actaagtcga gaaaaagaaa
     3961 atttagaaat acttgcttta tctgctgatg ttcataaagc tagtgattct gagaatttag
     4021 taaatactgc tttagataaa ttcggaaaaa ttgatatttt aattaataat tctgaaggag
     4081 catcatttgc tagtgacgca gtagaaacat tatcagatga tgactggcgg ctagtatttg
     4141 aagctaaatt aatgggttat attcgcatga ccaatttagt gttaccaggg atgaaaaatc
     4201 accaatgggg taggattatt aatattgtgg gtacatcagg aaaagaacct tcaccccggt
     4261 taattaaatc aggtgtggct aatgcagctt taatgaattt tactaaatct gtttctaccc
     4321 aaacagcgaa atttaatgtt ttgattacta cagttaatcc tggtttaatt gacacaccca
     4381 gacatcgcca gtatttagaa attgcagccc aggaggaaaa tcaatcagtt gatgtaatta
     4441 aatctcgaat tgctggtaaa attcctgctg gtcgtttagg tttgtctgat gaagtagcta
     4501 atttagtagt ctttttagcc tcagaatgtt ctagttatat cactggaata acgatcccta
     4561 tagacggggg attatctgtt tcggcttttt aattaagtaa ttcagtgatt aagtttgtag
     4621 attgatttgt atttgtggag attaataaaa atggtaacta tgcaaaattc tggtaataaa
     4681 accaataaaa acattgaagc tatttatccc ttatcatcaa tgcagcaggg gatgttattt
     4741 catagtcttt ataacccaga atcaaaggct tatttagcgc aagttcaaat tagtttgcag
     4801 ggtaatttag atatattgtc ccttgaaaaa gcttggtgta aagtagtaga acgtcatccg
     4861 gctttacgga ctgtgtttgt atggaaaaac cccaaacaac ctttacagat agtccagaaa
     4921 caagttaatg ttccttgggt taatttagat tggagttctc tatcatcaga tgtacaacaa
     4981 gagcaattag atactttttg tcaatctgat caggatgaat attttgccct ggataaagct
     5041 cctttgacgc gatttactct gatttctatg ggaaataaga gttatgaatt aatgtggagt
     5101 tcccatcaca ttttagctga tggctggagt ttgtcagtga tcatggcaga ggtttggcag
     5161 ttttatatag ctataaataa aggagaaact ttatatttat cacctacccg tccttatcga
     5221 gattatattg gttggttaca acagcaagat attaaacaag cggaaattta ttggcgtaaa
     5281 aatttgcaag gttttactgc aactacacct ttacaagttg ataatcttca ccgtaaaaaa
     5341 gatattagtc gagaatataa tcataagtat ttttcctttt cagcagaaga gacggctagt
     5401 ttaaaaaacc tagctcaaga aaattattta acattattta cactgataca agcagcttgg
     5461 ggaatacttt taagtcgtta tagtggtgaa gctgatgtag tttttggtgc taccatttct
     5521 ggtcgtcctc cggctttatc tggtgtagaa ttaatggttg ggttgtttgt gaatacttta
     5581 cctgtgcggg tgaaaattcc tgaagatatg ggaattttac cttggttaaa acagttgcaa
     5641 caagagcaaa ttgaacgaga agaatatggc catactccat tggtggaaat tcaaggttgg
     5701 agtgatatac cacgaggtca atctttattt gagagttttg tagtctttaa taatttaccc
     5761 ctgggtcaag agcttgggaa agcagatcat gatttacaaa taaccaagac taaaaatact
     5821 ggacacgctg attatcccct aactttgata gtgacaccag agaaagaatt aaaattaaat
     5881 ttgatttatg ctggcgatcg ctttgatcat gggacaattg agagaatggc aggtcatttg
     5941 caaactctgt tactaggaat tgtggctaat cctcaaagtc taccaggcaa attacctcta
     6001 ttaactcccc aggaagaaaa atttcttttg gtagatagta atcaaacagc agcggaaaat
     6061 ctgctccaag aaaatattca tgaattagtt acaaaatggt cagaaacaac acctgatgct
     6121 gtagctttgg tttttgctga tcaaaaatta acttatcggg aattaaataa ccgcgctaat
     6181 caattagctc actatttgca aaaattagga gtgggtgcag atatacctgt agggttgtgt
     6241 ttagagagag gtttagaagt agcgatcgct attctagcaa ctctcaaagc tggtggtgtt
     6301 tgtgtgcctt tagaccctaa ttatcctcca gaaagattgg ggttaatttt agcagatact
     6361 caagtacctg tgctgatcac gcaaagcaat ttacaagcct tacttcaatg tgatttccct
     6421 catcatcggt taattttaga tcaggaatgg acacaaatta atttagagaa caaaaccaac
     6481 ccaagcactc aaattacatc tgaaaactta gcttatataa tttatagttc tggttctaca
     6541 ggtaaaccta aaggaattga aactccccat tattgtctca cgaatttact tgcacatcac
     6601 ttaacaaaaa tggcttgtgg tgtaggggtt ttgcaatttg cttccttggg ttttgatgtt
     6661 aattttcacg aattatccgt cgctttgggt acaggtggaa ctctgtatat gattcccgaa
     6721 gatacccgat tagatttgga aaaattaatt caattattag taagtaattc cattcaaaaa
     6781 gtgattctta atgtgagtgt attacaagaa ctagcggaat tttgcagaca acagccagaa
     6841 ttgctgaaaa ataatctacg agaagtatct gctactggtg agcaattaca aattactcaa
     6901 ccaataattg atttatttaa acaacttaaa aattgctgtt tatataacta ttatggtcca
     6961 gcagaagcaa atttagtgac gacttatgcc tttagcgaaa atccagaaca atggcctgtt
     7021 tatgcaccca ttggtaaagc ggctgtcaat gtcaaagttt atattttaga caaacatttt
     7081 caaccagtac ccgtgggaat tgtgggagaa ttatatgtta gtggttatgg tttagcgcga
     7141 ggatattttc agcgtccaga attaacaaaa gagaaattca ttcctaatcc ctttgataaa
     7201 tcaccttatc atcgtctgta taaaactgga gatttagcaa gatatttacc agatggtaat
     7261 attgagtttt taggaagaat agatgatctc gtcaaaattc gcggttatca aattgattta
     7321 tgtgaagtcg aagcaatttt aagcaagtat cctcgcatta gtcaagcagt aacaactacc
     7381 catggtgaaa atgctaagga aaaatttctc gtcgcttact ttatcccggt aattaatgaa
     7441 actgttaatg cttctgaact gagaaaatat ctggctgctc aattaccaga ttatatgatt
     7501 ccttctgtat ttgtgcaaat ggattctttc cccttgaatc ctaatggtaa agttaaccgt
     7561 aaagttttac caattcccac gaatgagcga ccagaattaa atcaaatcta tattgcacca
     7621 caaaccccaa ttcaagaaat actagcagaa atttgggctg aagtattagg agttaaacaa
     7681 gtaggaattg atgataactt tttccaatta ggaggacatt cactcaaagc catacaatta
     7741 attgggaaaa ttcgtcaaac attagaattg gatattacta ttcgtcattt gtttacttct
     7801 cccagtgtca aagaattagc tactgcgcta ggagaattag ctggtggaga ggacattatc
     7861 aatgagattg ctaagactat tcaagaaatt gcccaacttt ccccagaaca attacaggca
     7921 atgttagcac agcagtaggt tcaaaaatac atcaatttca tcaaaataac aagaaagaat
     7981 actaggagaa aataccatga atacaattaa ttttttatcg cagttaagaa gtttagagat
     8041 cacaatttcc ctagaaggag aagaactgaa aattaaagct cccaaaggag taattacacc
     8101 atctttaaaa gcggaaatag tgcaacgcaa accggaaatt attgctgttc tccaagaggc
     8161 taaaacttcc actcaagatg tttttgtacc catagcttct gtagatagaa cgggtatgtt
     8221 acccctgtct tataaccaaa gctcaatgtg gtttatacat caattagatc aagataatac
     8281 ggcttataat gaatctttac aattgaaaat taaaggtcag ctaaagatca cgattttaga
     8341 acaaagtatt caagaaatta ttcgtcgtca tgaaagttta agaactgctt ttcctgctat
     8401 tgacgggaat ccttatcaaa aaatcaattc tcattttact tttcatctgc caattataga
     8461 tttacaaact tatttagaaa cagaaatatc atcttatatt acccgcgaag ttcgtcaatc
     8521 ttttaactta gaaaacggtg atttatggcg atttaaacta ttgcgtacag gtgcagatga
     8581 gtacattctc ctaattatta
//
