LOCUS       c00134_3300014..       13573 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300014869.a:Ga0180298_1000212.
ACCESSION   c00134_3300014..
VERSION     c00134_3300014..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 06:54:14
            Original ID  :: 3300014869.a:Ga0180298_1000212
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13573
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13573
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4857:9861](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4858..9861)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..13573
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13573
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             complement(683..2740)
                     /gene_functions="other (smcogs) SMCOG1037:heavy metal
                     translocating P-type ATPase (Score: 427.3; E-value:
                     1.9e-129)"
                     /gene_kind="other"
                     /locus_tag="ctg134_1"
                     /transl_table=11
                     /translation="MILETFALGSILYIGFKSFKKQGKAKKSWKATNTTMKSVLEDQFT
                     QIVGQSDDKKSSSGLTFEEKNKREIISASSALTLSSIGAWLYYWPLSFMSIPLVIYASK
                     SYHKKTYELIKQGKASTETLVSITMTGCIILGRFSMASLIVLLFGVAARLAMQVTQNSR
                     QLLINTFEQHPDFVWIRVKNAEISIPFNELQQGDIVVVHTGEMIPADGTVVNGMATVDQ
                     HILTGEAKPVEKESGEEVFASTVVLSGKINVKAEKTGENSTVAKITHILNSTVDFKSTL
                     QLRADTLSKQLVNPALIAGSVALPILGFNGALAVVNAHPKNKMMGIAPIGIMNYLNLAS
                     KQGILIKDGRSLEFLNKVDTIVFDKTGTLTEEQPHIGTIHSDSDYTEDEILIYAAAAEY
                     KQKHPLAKAILQEAENRQLSIPSIEDSEYKLGYGITVNVAGKVVHVGSERFMAVENILI
                     SPTLSEQQKRSHEEGYSLVMVAVDKHLAGAIELLPTVRPEAKAIISHLKQRQNIKATYI
                     ISGDHEIPTKKLAKALGVDHYFAETLPEDKAGIIEQLQQEGHFICYIGDGINDSIAMKK
                     SHVSVSLAGASTIAIDTAQIILMDSGLNHLNLLFDLANKFNANMNTTFAIILIPAVISV
                     SGAFLLGFGLTQTVVLNMSGIILAIGNAMTPLLKQPEKQLQSEASTDRSK"
     CDS             3475..4368
                     /locus_tag="ctg134_2"
                     /transl_table=11
                     /translation="MNTMIRFTRILICLGLALCASYAGAETQAPTTKPQIKLYVFDCGI
                     LNYDDDTLKFFSVSASETTVRDLFVPCYVIEHKQGRLLWEGGLPSNSLTGAYGWQENKG
                     WRMRLDKTFQEQLAQIGLGMDDFDYMAFSHLHFDHIGVANEVKGGTLLIQKDEYDAAFA
                     EKVTVPAFKPELYNKLEQADKVILNGEHDVFGDGRVRLIPAPGHTPGHQVLFLDLNETG
                     PIVLSGDLYHFRLSRERKLVPIFNVDKEKSLNSIEHIEQFLKESGAELWIEHELAQYEQ
                     IKKMPGCKLSPVLHCI"
     CDS             complement(4858..9861)
                     /NRPS_PKS="Domain: Condensation_Starter (8-296). E-value:
                     1.1e-88. Score: 289.2. Matches aSDomain:
                     nrpspksdomains_ctg134_3_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (462-869). E-value:
                     2.5e-108. Score: 354.0. Matches aSDomain:
                     nrpspksdomains_ctg134_3_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (980-1047). E-value: 6.6e-21. Score:
                     66.1. Matches aSDomain: nrpspksdomains_ctg134_3_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1418-1653). E-value:
                     9.7e-39. Score: 125.8. Matches aSDomain:
                     nrpspksdomains_ctg134_3_Thioesterase.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     281.5; E-value: 2.5e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg134_3"
                     /sec_met_domain="Condensation (E-value: 5.6e-56, bitscore:
                     178.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 7.3e-117, bitscore:
                     379.0, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 6.3e-15, bitscore:
                     44.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSNQTLKHYPLSSPQREIWFDQILHPDVPLYNIGGYVRIDGPID
                     PALFEKALNQVIAENDALRISLHEGESLPTQTFAENVHLKLDFYDFSEQENAHKSALDW
                     IRCEFVKPFQLYDGLLFHFALCKASSLCYYWLKKYHHLIADGWTMSLIVQRVAIAYNAM
                     GQSDCEHHSYKNFLQKDQAYLDSKQFVKDKHYWVNKYRELPEPLLVHQNASQTMKSQRS
                     VLRLKRPFYNQLIEFAKENKVSTFHVILGALYCYFVRTYDREDLVIGLPTLNRSSAAFK
                     QTVGLFVGVSPAKFRFGLDLNFIELIQAIRGILQTNYRYQRFPISELNRQLGLQRENRQ
                     QLFDLTLSYMDQNYDANFEGSTVEFTLLPHTNEQNALAIFVDDFHKQSDIKVDFDYNLG
                     AFDADEIERLKARFEFLLGKILRHPLVPVRSQQIMPDVELNKILVEWNDTETYYPHNKT
                     IVDLFEEQVDKTPDAIAVVFENQQLTYFQLNSKANQLAHYLQTLGVKPEVLVGICVERS
                     VEMVIGLLGILKAGGAYLPLDPAYPAERLAFMLEDAQVPVLLTQSSLKEKLPDIQAQVV
                     CMDVKAKTLSRLSSENLISEVTPTNLAYVIYTSGSTGKPKGAGLSHRGFTNLVNWFVTD
                     FNLTATDSVLVISSEGFDLTHKNFFAPLIKGGQLHLLPASIRYDPNKITQIVATQNITW
                     LNCTPSAFYPLIEPSEESIFQKLASLRYIFLGGETISLTRLWPWLQSSACQAKLVNTYG
                     PTECTDVCAAYLLEEPSLFLDKSIPIGKPIFNAKLFILGKHLELLPVCVAGELYIGGVG
                     LGRGYLNCPELTAEKFINNPFDDDPNSRLYKTGDLARYLPDGNIEYLGRIDNQVKIRGF
                     RIELGEIEAVLSTHPTVRESVVIAHEVSEGDKHLVAYCVAQTDQVIENQALRAFLKERL
                     PDYMVPAFWVEIEAMPLTPSGKIDRRALPIQTLTREALEKAYVAPQTALEYLIAELWHS
                     ILGVEQIGIEDNFFELGGTSISGMVFINRLQEKLQSHLYPIALFEAPTIADFAAYLKTH
                     YTEAVSKLCHTEAGLESIQSASHPPIDSSKVSQLRQLIAESPFFATRFSHVKEETERLP
                     SAIFILSPPRSGSTLLRVMLAGHPNLFVPPELELLSFENLQERNALFSGPYQFALEGTI
                     RAMMALKGCTMEQAANLMAEYENQHLTTRQFYHLIQTGCGKKTLVDKTPSYALALNTLK
                     RAESYFENARYIHLLRHPYGMIHSFEEAKFDQLWFRFEHHFSARELGELTWLISQQNIR
                     DFLQEIPTERQLQVRFEELVHKPRSVLDSLCHFLGLAFHPDMLQPYQNKQQRMTDSLYH
                     VSKMVGDPKFHTHKQVEAQTADRWRNTYTQDFLGEVTWEMAESFGYQKILDDSHQVPSR
                     LSSPLVTLQPGDKNRLPFFCIHPIGGNVFWYMNLARHLGTKQPFYGLQSAGLYGERKPL
                     TRIEGMARLYIEALQTIQPQGPYQLGGWSLGGVVAFEMAQQLRKQGHQIKLLTLIDSYV
                     PSNFPSDIDETQLMTLFTRDLRGIFGNPFTLAERQQRESDSYQQLNLTLEQAKKLNDLP
                     ANLKQQEHLWQVFKSNRLAMTRYQPQRYLGRLIWFGATDSRITASKAISEWQELASDIE
                     TDTFPGDHYSLLQEPTVKLLAEKLSTYLN"
     aSDomain        complement(4903..5607)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg134_3_Thioesterase.1"
                     /evalue="9.70E-39"
                     /label="ctg134_3_Thioesterase.1"
                     /locus_tag="ctg134_3"
                     /protein_end="1653"
                     /protein_start="1418"
                     /score="125.8"
                     /tool="antismash"
                     /translation="PFFCIHPIGGNVFWYMNLARHLGTKQPFYGLQSAGLYGERKPLTR
                     IEGMARLYIEALQTIQPQGPYQLGGWSLGGVVAFEMAQQLRKQGHQIKLLTLIDSYVPS
                     NFPSDIDETQLMTLFTRDLRGIFGNPFTLAERQQRESDSYQQLNLTLEQAKKLNDLPAN
                     LKQQEHLWQVFKSNRLAMTRYQPQRYLGRLIWFGATDSRITASKAISEWQELASDIETD
                     TFPGDHYSLLQEPT"
     aSModule        4903..9837
                     /complete
                     /domains="nrpspksdomains_ctg134_3_Condensation_Starter.1"
                     /domains="nrpspksdomains_ctg134_3_AMP-binding.1"
                     /domains="nrpspksdomains_ctg134_3_PCP.1"
                     /domains="nrpspksdomains_ctg134_3_Thioesterase.1"
                     /final_module
                     /locus_tags="ctg134_3"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(5353..5427)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0011"
                     /evalue="1.20E-15"
                     /label="NRPS-te1"
                     /locus_tag="ctg134_3"
                     /protein_end="1503"
                     /protein_start="1478"
                     /score="49.6"
                     /tool="antismash"
                     /translation="QPQGPYQLGGWSLGGVVAFEMAQQLR"
     CDS_motif       complement(5578..5607)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0010"
                     /evalue="1.20E-02"
                     /label="NRPS-beforete1"
                     /locus_tag="ctg134_3"
                     /protein_end="1428"
                     /protein_start="1418"
                     /score="8.8"
                     /tool="antismash"
                     /translation="PFFCIHPIGGN"
     aSDomain        complement(6721..6921)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg134_3_PCP.1"
                     /evalue="6.60E-21"
                     /label="ctg134_3_PCP.1"
                     /locus_tag="ctg134_3"
                     /protein_end="1047"
                     /protein_start="980"
                     /score="66.1"
                     /tool="antismash"
                     /translation="YLIAELWHSILGVEQIGIEDNFFELGGTSISGMVFINRLQEKLQS
                     HLYPIALFEAPTIADFAAYLKTH"
     CDS_motif       complement(7225..7290)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0009"
                     /evalue="1.30E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg134_3"
                     /protein_end="879"
                     /protein_start="857"
                     /score="39.5"
                     /tool="antismash"
                     /translation="YLGRIDNQVKIRGFRIELGEIEA"
     aSDomain        complement(7255..8475)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg134_3_AMP-binding.1"
                     /evalue="2.50E-108"
                     /label="ctg134_3_AMP-binding.1"
                     /locus_tag="ctg134_3"
                     /protein_end="869"
                     /protein_start="462"
                     /score="354.0"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FEEQVDKTPDAIAVVFENQQLTYFQLNSKANQLAHYLQTLGVKPE
                     VLVGICVERSVEMVIGLLGILKAGGAYLPLDPAYPAERLAFMLEDAQVPVLLTQSSLKE
                     KLPDIQAQVVCMDVKAKTLSRLSSENLISEVTPTNLAYVIYTSGSTGKPKGAGLSHRGF
                     TNLVNWFVTDFNLTATDSVLVISSEGFDLTHKNFFAPLIKGGQLHLLPASIRYDPNKIT
                     QIVATQNITWLNCTPSAFYPLIEPSEESIFQKLASLRYIFLGGETISLTRLWPWLQSSA
                     CQAKLVNTYGPTECTDVCAAYLLEEPSLFLDKSIPIGKPIFNAKLFILGKHLELLPVCV
                     AGELYIGGVGLGRGYLNCPELTAEKFINNPFDDDPNSRLYKTGDLARYLPDGNIEYLGR
                     IDNQVKIRG"
     CDS_motif       complement(7378..7467)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0008"
                     /evalue="1.70E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg134_3"
                     /protein_end="828"
                     /protein_start="798"
                     /score="49.1"
                     /tool="antismash"
                     /translation="PVCVAGELYIGGVGLGRGYLNCPELTAEKFI"
     CDS_motif       complement(7996..8055)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0007"
                     /evalue="8.30E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg134_3"
                     /protein_end="622"
                     /protein_start="602"
                     /score="27.6"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGAGLSHR"
     CDS_motif       complement(8248..8289)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0006"
                     /evalue="1.70E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg134_3"
                     /protein_end="538"
                     /protein_start="524"
                     /score="17.9"
                     /tool="antismash"
                     /translation="LGILKAGGAYLPLDP"
     CDS_motif       complement(8815..8916)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0005"
                     /evalue="1.30E-10"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="ctg134_3"
                     /protein_end="349"
                     /protein_start="315"
                     /score="33.8"
                     /tool="antismash"
                     /translation="TNYRYQRFPISELNRQLGLQRENRQQLFDLTLSYM"
     aSDomain        complement(8974..9837)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg134_3_Condensation_Starter.1"
                     /domain_subtype="Condensation_Starter"
                     /evalue="1.10E-88"
                     /label="ctg134_3_Condensation_Starter.1"
                     /locus_tag="ctg134_3"
                     /protein_end="296"
                     /protein_start="8"
                     /score="289.2"
                     /tool="antismash"
                     /translation="HYPLSSPQREIWFDQILHPDVPLYNIGGYVRIDGPIDPALFEKAL
                     NQVIAENDALRISLHEGESLPTQTFAENVHLKLDFYDFSEQENAHKSALDWIRCEFVKP
                     FQLYDGLLFHFALCKASSLCYYWLKKYHHLIADGWTMSLIVQRVAIAYNAMGQSDCEHH
                     SYKNFLQKDQAYLDSKQFVKDKHYWVNKYRELPEPLLVHQNASQTMKSQRSVLRLKRPF
                     YNQLIEFAKENKVSTFHVILGALYCYFVRTYDREDLVIGLPTLNRSSAAFKQTVGLFVG
                     VSPAKFRF"
     CDS_motif       complement(8986..9069)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0004"
                     /evalue="2.80E-09"
                     /label="C5_starter_265-294"
                     /locus_tag="ctg134_3"
                     /protein_end="292"
                     /protein_start="264"
                     /score="29.4"
                     /tool="antismash"
                     /translation="DLVIGLPTLNRSSAAFKQTVGLFVGVSPA"
     CDS_motif       complement(9382..9447)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0003"
                     /evalue="4.50E-08"
                     /label="C3_starter_134-155"
                     /locus_tag="ctg134_3"
                     /protein_end="160"
                     /protein_start="138"
                     /score="25.9"
                     /tool="antismash"
                     /translation="YHHLIADGWTMSLIVQRVAIAYN"
     CDS_motif       complement(9655..9774)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0002"
                     /evalue="2.10E-19"
                     /label="C2_starter_024-063"
                     /locus_tag="ctg134_3"
                     /protein_end="69"
                     /protein_start="29"
                     /score="62.0"
                     /tool="antismash"
                     /translation="PLYNIGGYVRIDGPIDPALFEKALNQVIAENDALRISLHEG"
     CDS_motif       complement(9793..9834)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg134_3_0001"
                     /evalue="1.50E-03"
                     /label="C1_starter_004-017"
                     /locus_tag="ctg134_3"
                     /protein_end="23"
                     /protein_start="9"
                     /score="11.3"
                     /tool="antismash"
                     /translation="YPLSSPQREIWFDQI"
     CDS             complement(10063..10389)
                     /locus_tag="ctg134_4"
                     /transl_table=11
                     /translation="MRTVLASFKQKGYYEKDKSDNIDIIKQMITVSEMYRGNEEVVRAD
                     SLQQGEEISSVKWFLRGRLEFSDLVDEVGEQKANRVQQNAANLRVAVENGTPWLKILEQ
                     LDEK"
     CDS             10865..13324
                     /locus_tag="ctg134_5"
                     /transl_table=11
                     /translation="MIKKCVVLIALLCPNLLQSAPLSEPASLRDSLPPEAISYLRIPNP
                     WGFLTAPKGSVLNDALANEQHVQQIQNLESAIYQNLLNLSQADLHPALRFFFHHLRSPI
                     EAVALLPEHMPPHLANHLISAKLDLTSIEAFNQLLTQLVAKTDALSIVNPLSKDGYGLL
                     IVAQMLPLFLHYNVNTRTVYLMGGFTATEAIFKKTLAGLAPVTHHPMFDMEKQVDTSAQ
                     GFFQWINFQRLSPILLNKIHPDIISQWHKWGVTSLRAVALGWGVSEGKGRLKLILDMPR
                     TGFRQLFPGISNNLTLTASGQPQTVISFSIPALTWLTEFEKIADQVLSHDDVQAYYAFK
                     TELQTEMGYSLETLLGALGPQMLFFSDEVGYFVAFQINNRNMMQKVFTALMKKYDWASY
                     ESREIKGKTYHHLKTAFIQKAIEDNPYFLSPSSAGKKAFVLFWTQFISNLKTHYYWVEE
                     DGYLIFATLPQFLLDRQQSSSARVPLQTWLKEKQGQDNQSSLFLLSTTFSETPRKLYHA
                     YLYSLVLLGDVFETEIDLFTLPTARELSLPMQGTYGIQFDISDSQLSLELVFENNPLEF
                     IFEGGMSTVAIAGIMAAVAIPAYNDYMLKSKISAGMRLLNTMKTKAEVFRLEEGRFPTV
                     KELEMPRQGTYTKNLRLLKRKNGYAIGFKDPALPGVLKLIFNHKTQRWRCTHQNLQKKY
                     LPRHCRGVIKERPKKRIKKSIGDDNRNKQQVAKALSLLNDFAKRAKEYFAVLGTLPTTQ
                     EIEDIWGLKSPQGLHIQLLETKDGYYTLFEKPAISGRLILRGNANNRSWTCTHDGMLER
                     YLPEECK"
     CDS             complement(13441..13572)
                     /locus_tag="ctg134_6"
                     /transl_table=11
                     /translation="HSIFIPNGEMVGKRAASIWVYIEFIAARLPTLQILGEKKSSRT"
ORIGIN
        1 cgatgcatcg cgtctctaca aggtgttttg atgagagcgt ttcgacgcga ttcagaaacg
       61 cgattagaga cgcgatgcat cgcgtctcta caaggtgttt tgatgagagc gtttcgacgc
      121 gatgcttcgc gtctttgctt ttcaaaagat atttttcttt tgtatttttc gaacccaccc
      181 tacaaacgac tgggataatt tattttttgg agattcctta actgaaacga agaactcaat
      241 atgccaatga ggcttttgca aaacaggtaa taggtgtcat gatggcaata tcctgaggca
      301 tgtgacgaaa gaataatcaa ttatctgtca tggaaatttt ttgagaggcg cattactgat
      361 agcaacgctg ccgaaagcag cacttactaa aagcgcagtc agaattccaa aatgtaatac
      421 tcaatgctca agtttttgat gtgatttggc tttgcggcag tcacagattg agtgtctata
      481 tatgcaaatc attgattatt aaggaattta agttttatac cttaaaattt tttaggaaat
      541 ggaaaccttc gcttttttca tcgcaatgct atcgttgatg ccgtcaccga caaaacagag
      601 ccattttcct ttcgtttgct tcgatgagat ggccggtaaa atttcagcaa aatcatgttt
      661 tatgccatta ccatcacgtt tttcatttgg aacgatctgt tgatgcctcc gattgaagtt
      721 gcttttcagg ctgttttaac aagggtgtca ttgcattacc tatcgcgaga atgataccgc
      781 tcatatttaa gacgacagtt tgggttaggc caaaacccaa taaaaaagcg ccactgacac
      841 tgataacagc gggtatcaat ataatggcaa atgttgtatt catattggca ttaaatttat
      901 tagccagatc gaatagcaaa tttaaatgat ttaaaccgct gtccattaag ataatctgcg
      961 ctgtatcaat ggcgatagtg gaagcacctg ctagggaaac ggaaacatga gattttttca
     1021 tggcaattga atcattgata ccatcaccaa tataacaaat aaaatgccct tcctgctgta
     1081 attgctcaat gatacctgct ttgtcttctg gcaaggtttc ggcaaaatag tgatcgacgc
     1141 caagtgcttt ggctagtttt ttcgttggta tctcatgatc gccggagata atataggtgg
     1201 ctttgatgtt ttggcgttgt tttaaatggc tgataatcgc ctttgcttct gggcgcactg
     1261 tgggcaacag ttcaatagcc cccgcgagat gtttatcaac agccaccata accaaactat
     1321 agccttcttc atgactgcgt ttttgttgct cactaagcgt cggcgaaatt aaaatgttct
     1381 ctaccgccat aaaccgttca ctgcccacat ggacgacttt tcccgcaacg ttaacggtta
     1441 tcccatagcc caatttatat tcgctatctt ctatagaagg tatgcttaat tgccgatttt
     1501 cagcttcttg cagaatagcc ttggctaggg gatgtttctg tttatattcg gcggcggcag
     1561 cataaatcaa aatctcatct tcagtataat ctgaatcaga gtgaatggta cctatatggg
     1621 gctgttcctc agtcaaagta ccggttttat caaatacaat tgtatcaact ttgtttaaaa
     1681 attctaaaga acgcccgtct ttaattaaaa ttccttgttt agaagccaaa ttgagatagt
     1741 tcatgatacc aatcggcgca atacccatca ttttattttt aggatgggcg ttaaccacag
     1801 ctaatgcgcc attaaaacct aatatcggta atgcgacact acccgctatc agtgctgggt
     1861 tcactaactg tttagaaagt gtatcagcgc gtaattgtaa agtggattta aaatcaactg
     1921 tactattcaa tatgtgagtg attttcgcga cggtgctatt ttctcccgtt ttttctgctt
     1981 tcacgttaat ttttccagat aaaacaaccg ttgaggcaaa tacttcttca ccagattctt
     2041 tttctactgg ctttgcttcg ccggttaaaa tatgttgatc aacagttgcc atcccgttta
     2101 caaccgtacc atctgctggg atcatttctc cagtatggac gacgacaata tcgccttgtt
     2161 gtagttcatt aaacggtatg ctgatttcag catttttaac cctaatccaa acaaaatcag
     2221 gatgttgttc aaatgtgtta atcaacaatt gtctggaatt ttgagtcact tgcatcgcaa
     2281 gtcgtgcggc gactccaaat aataaaacga ttaagctggc catcgaaaaa cgtcccagaa
     2341 taatacagcc tgtcatagtg atgctgacta gcgtttcagt actggctttc ccttgtttga
     2401 ttaactcgta tgttttttta tggtacgatt tgctcgcata gataacaaga ggaatgctca
     2461 tgaagcttaa tggccagtag tacaaccaag cccctattga agacagcgtc agtgctgacg
     2521 aggcacttat aatctcacgc ttattttttt cttcaaacgt gagccctgaa gaagattttt
     2581 tgtcatctga ctgcccaaca atttgtgtaa attgatcctc cagtacactt ttcattgttg
     2641 tgttagtggc tttccatgat tttttcgctt tgccttgctt tttaaagctt ttgaaaccaa
     2701 tatataaaat gctgcctaaa gcgaatgttt cgagaatcat agcattacct cactcattgc
     2761 gttttgtgtc aatactgatg ttgatgccat tattgatatc aatatcgcat gaaatagaca
     2821 gcccaaaaaa gctcacagtg aacaccctag agcgatacca caataaaaat ttctttgtct
     2881 aataggtaga aatataaagc aatctttata caaaagcaaa aaaattttaa ttttactata
     2941 gattatagct gtgtatgata ttgccatatt ttcttattga tagagcttta tttatcatta
     3001 taaaatttaa tggtaataga taatagacat tataccgatt aaattatagc gtttcccgat
     3061 tgaataaggt acagtgatat caagaaaatt gaagcgcaaa ataaattttg cactcccaga
     3121 aggccgcaaa ataaattttg cactcccaga aggtagcaaa ataaattttg cactcccaga
     3181 aggccgcaaa ataaattttg cactcccaga aggccgcaaa ataaattttg cactcccaga
     3241 gggccgaaaa ataaattttg cactcccaga aggccgcttt tcagtcaaat aatttgtact
     3301 tcattcaatc gagaaacgct atataagtgc ttgatttcct tgtcccaaaa tgggaatttt
     3361 aagaaaatct tgtgttaaat cggtataatg tctaatataa atagaacttt gctacttgat
     3421 ttgtagaaac tcgttgtaca ggaataggtt tgcaacacca acataagagg tattatgaat
     3481 acaatgatcc gattcacgcg aatactgatt tgtctcggct tagcgctttg cgctagttac
     3541 gctggtgcag agactcaagc gccaacgact aaaccacaga tcaagctcta cgtgtttgac
     3601 tgtggaatac tgaactatga cgatgacact ttgaagtttt ttagcgtttc tgctagtgag
     3661 accactgtgc gtgatctctt tgtgccctgt tatgtcattg aacacaagca aggcagactg
     3721 ttgtgggaag gcggactacc ctcaaatagt ctaaccggtg cttatggttg gcaggaaaat
     3781 aaaggctggc gtatgcggct tgacaaaacc ttccaagagc agttagccca aatcggcttg
     3841 ggcatggatg acttcgatta tatggccttt tcacatctgc acttcgatca tatcggggtc
     3901 gcgaatgagg ttaaaggggg gacgttactg atccagaaag atgaatacga tgccgctttt
     3961 gctgagaaag tgactgtacc tgcttttaaa cctgagttat ataacaaact tgagcaggca
     4021 gacaaggtta tcctcaatgg tgaacacgat gtattcggag atggtcgggt tcgactcatt
     4081 cccgctcctg ggcatacgcc cggtcatcaa gtcttgtttc ttgatttgaa tgaaaccgga
     4141 ccgattgtgc tatcgggtga tctctatcat ttccgcctta gccgggaaag aaagcttgtg
     4201 cctattttca atgtggacaa ggagaaaagc cttaactcaa tagaacacat tgagcagttt
     4261 ctcaaggaga gtggtgctga actctggata gagcatgaat tagcccaata tgaacaaatc
     4321 aagaagatgc cagggtgtaa actgtcgccc gtattgcact gtatttgatt tcttgacaag
     4381 ttgctttttt catcaatact ttgatctatg tacaggacaa ataaatataa tgctttgatt
     4441 tttatattaa aattaactgt atttcacgct aaagtttcgc ggagcgaaac tttagcgtga
     4501 agcttaggat aagggattgt ttccattgtc gatttgcact gcctcgcgtc tcgacgaaaa
     4561 cagataggta gggggcaacc agagccacct atccgttttc aaatcggggt ttaaaaagac
     4621 atacatttac aaagcatttt gtatcacaga tggtgggcta catttatatt tttttgtcct
     4681 gtacatagcg ggagcgggcg gattggtgtt attgggcaca ttgtcgcctg tttttttcat
     4741 gttaggctgt gtagccgttt tatttatata ttgcgcgtaa agcccctgtg atacgatcca
     4801 ttctgaaaat tctggttcag acatttttat actttggaat cgatttatgg acgagcacta
     4861 attaagataa gtactcaatt tttcagctaa aagcttgaca gtcggttcct gtaggaggct
     4921 gtaatgatca ccaggaaagg tatctgtttc tatatcactt gctaattctt gccattctga
     4981 tatggctttt gaagccgtta tcctagaatc agtggcacca aaccaaataa gtcgtccaag
     5041 atagcgttgg ggttgataac gagtcattgc caaacggttg cttttaaaaa cctgccacaa
     5101 atgttcttgt tgttttaggt tggcgggtaa gtcatttagc tttttggcct gttccaaggt
     5161 taaattcaat tgttgataac tatcagattc acgttgctgg cgttctgcca aggtgaaagg
     5221 gttgccaaaa atacccctta aatcacgagt gaataatgtc atcagttgag tttcatcaat
     5281 atcagaggga aagttgctag gcacataact gtctatcaaa gtcaacaatt ttatttgatg
     5341 accttgcttt cgcaattgtt gggccatttc aaaagccact actcccccta aggaccaacc
     5401 gcccaattgg taaggccctt gaggttgaat cgtctgtaag gcctcaatat agagacgggc
     5461 catgccttca atgcgtgtta agggtttgcg ttctccataa agtccggctg attgtaaacc
     5521 ataaaagggt tgtttagtac ccagatgacg cgctaaattc atgtaccaaa acacgttccc
     5581 gcctatcgga tgaatgcaga agaaaggtaa tcggttttta tcaccaggct gaagggttac
     5641 caaaggagaa ctcaatcttg aagggacttg atgggagtcg tccaatattt tttgataacc
     5701 aaacgattct gccatttccc aagttacctc cccaaggaaa tcctgagtgt acgtgtttcg
     5761 ccagcgatct gctgtttgtg cttcaacttg tttatgggta tgaaatttcg gatctccaac
     5821 catttttgaa acatgataaa gactatccgt catgcgctgc tgtttgtttt gataaggttg
     5881 cagcatatca ggatgaaatg ctaaccctaa gaagtggcat aaactgtcta aaacgctacg
     5941 aggtttgtgt accagttctt caaatctgac ctgaagctgg cgttcagtgg gtatctcttg
     6001 caaaaagtct cgaatatttt gctgactgat gagccaagtt aattcgccta attcgcgtgc
     6061 agagaagtga tgttcaaatc gaaaccacag ttgatcaaat ttcgcttctt caaatgagtg
     6121 aatcatgcca taagggtgtc gaagtaggtg gatataacgg gcgttttcaa aatagctttc
     6181 agcgcgtttg agcgtgttta gtgccagcgc gtaagagggc gttttatcaa ccaaggtttt
     6241 tttaccacac ccagtttgta tcagatggta aaattgtcgc gtggttaaat gctggttttc
     6301 atattcagcc atcaggttgg cggcttgttc catcgtgcag cctttaagtg ccatcatagc
     6361 tctaatggtg ccttccaacg caaattgata gggccctgaa aaaagggcat ttctctcttg
     6421 aaggttttca aaagacagca attctaattc tggtggcaca aataaatttg gatgtccagc
     6481 taacattact cttaataaag tggaaccaga gcgtgggggc gataaaataa aaatggccga
     6541 tggtaatcgt tccgtttctt ctttgacgtg cgaaaaacga gtagcaaaaa atggactttc
     6601 agcgattaat tggcgtagtt gggacacttt cgatgaatct atcggcggat gggaagccga
     6661 ttgaattgac tcaagccctg cttcagtgtg gcacagtttt gacaccgctt ctgtgtaatg
     6721 cgtttttaga taggctgcaa aatcagcaat agtcggtgcc tcaaataggg ctattggata
     6781 aagatgactc tgtagctttt cttgaagtcg attaataaaa accatcccac taatggaagt
     6841 accccctaat tcaaaaaaat tatcctcaat accgatctgc tcgactccca atatcgaatg
     6901 ccatagttca gcgataaggt actctaatgc cgtctgaggt gcaacataag ctttttctaa
     6961 ggcttctctc gtcagagtct ggatcggtaa cgcacggcga tctattttac cacttggtgt
     7021 cagtggcatc gcctcaattt ctacccagaa tgcgggtacc atgtaatctg gtagcctttc
     7081 tttgaggaat gcgcgtaaag cttggttttc tatcacttga tcggtttgag ccacgcagta
     7141 agccactaag tgcttatccc cttcagacac ttcatgggca atcaccacac tttctcgcac
     7201 agtaggatga gtagaaagca ccgcttcaat ttcaccaagc tcaattctaa agccgcgaat
     7261 tttgacttgg ttatctatgc ggcctaagta ttctatattg ccgtcaggaa gatagcgtgc
     7321 caaatcacca gttttataga ggcgtgaatt tggatcatca tcaaagggat tattgatgaa
     7381 tttttctgcc gttaattctg ggcagttgag ataaccacga cccaagccca caccaccgat
     7441 gtaaagttca ccggctacac acaccggtaa gagttcaaga tgtttgccta gaataaaaag
     7501 tttggcatta aagataggtt tacctatggg tatgcttttg tctaaaaaga gcgagggttc
     7561 ttccaataaa taggccgcgc aaacatcggt acattcggtg gggccataag tgttgaccag
     7621 tttcgcttga caagcactag actgtagcca aggccaaagt ctggttaaag aaatggtttc
     7681 gccccctaga aagatatagc gcaatgaagc taatttctgg aatatgcttt cttcactagg
     7741 ttctatcagt ggataaaacg cgctgggggt gcagtttagc caagtgatgt tttgtgtcgc
     7801 aacgatttgg gtgattttat ttggatcata acgtatagac gctggcaaga gatgcaattg
     7861 tcccccttta atcagtggtg caaaaaagtt tttatgagtc aaatcaaaac cttcgctcga
     7921 aataacgagg acactatcag ttgctgtcag gttaaaatcg gttacaaacc aattgactaa
     7981 attggtaaaa ccacgatgag aaaggccagc acctttaggc ttccccgtcg aaccagacgt
     8041 ataaatgaca tacgctaaat tcgtaggtgt cacttcactg attagatttt cagaactcaa
     8101 gcgtgacagc gttttggcct taacatccat acaaaccacc tgcgcttgaa tgtctggcag
     8161 tttctctttt aaactagatt gagtcaacaa cacgggcact tgggcatctt ccaacataaa
     8221 cgctaaacgc tccgctggat aagccggatc aagtggcaaa tacgcgcctc ccgctttgag
     8281 gattcccagc aatcctatta ccatttcaac agaacgttcc acacagatac ccaccagtac
     8341 ttctggttta acacccaaag tttgcagata gtgggccagt tgattggctt tgctatttaa
     8401 ttgaaagtaa gtcagttgtt ggttttcaaa aacaacggcg atggcatctg gcgttttgtc
     8461 aacctgttct tcaaatagat caactatcgt cttattatgc ggataatatg tttcggtgtc
     8521 gttccattca actaatattt tatttaattc cacatcgggc atgatttgct gtgaacgaac
     8581 cggcaccaaa gggtgacgga ggattttacc taacaaaaac tcaaaacgcg ctttgagacg
     8641 ttcaatttca tcagcatcaa acgctccaag gttataatca aaatcaacct taatatcact
     8701 ttgcttatga aaatcatcaa caaagatggc taaagcattt tgttcatttg tgtgtggtaa
     8761 aagggtaaac tcgactgtgc taccctcaaa attcgcatca taattttgat ccatataaga
     8821 cagcgttaaa tcgaaaagct gttgtcggtt ttcccgctga agccctaatt gtcggttgag
     8881 ttcactgatt ggaaaacgct gataccgata atttgtttgc aatattcccc taatggcttg
     8941 aattaactca ataaagttta aatccaagcc aaaacggaac tttgctggac tgacacccac
     9001 aaacaggccc actgtttgct taaaggctgc gctactccga ttcagtgtcg gtaatccaat
     9061 aaccaaatct tctcgatcat atgttctgac aaaataacaa tataatgccc ctaaaataac
     9121 gtggaaagtg gataccttat tttctttagc aaattcaatc agttgattgt agaaaggccg
     9181 cttgaggcgc aaaactgagc gttggctttt catcgtttgg ctagcatttt gatgcaccaa
     9241 aagcggctct ggtagttcac ggtatttatt tacccaataa tgtttgtctt taacaaactg
     9301 tttagagtct aagtatgctt gatccttttg gagaaaattt ttataagagt gatgctcaca
     9361 atcagattgt cccattgcgt tataggctat ggcaactcgc tgcacaatca gagacatcgt
     9421 ccagccatcg gcaatcagat gatgatactt ttttaaccag taataacata gtgaagaggc
     9481 tttgcataat gcaaagtgaa acaataaccc gtcataaagt tggaaaggct tgacaaactc
     9541 gcagcgaatc caatcaagtg ccgatttgtg agcattttcc tgttcagaga aatcataaaa
     9601 gtccagtttc aggtgaacat tttcggcaaa ggtttgcgtg ggcaaacttt ccccctcgtg
     9661 aagactgatg cgtagggcat cgttttctgc aatgacttga ttgagggctt tttcaaacag
     9721 ggccggatca atagggccat ctatccgcac atagccaccg atattgtaca gtggcacatc
     9781 tggatgcagg atttggtcga accatatttc ccgttgaggg gaggagaggg ggtaatgctt
     9841 aagggtttgg tttgaagtca tgttaaaatt cctttttgat aaaacttctc aataacgaca
     9901 agaattgcct ataataacga gtggaagctt tcgcgattga aaaaaataaa cgcgctttga
     9961 cgctaaaaac gctatctctc aatcgaaata ttgcatcctt gcgtctcttg cgtctcttgc
    10021 gttatttttt cgtttgataa ataaaccaaa gcaacatact ccctattttt catctaactg
    10081 ttccaatatt ttcaaccagg gtgtcccgtt ttccactgca actcttaaat ttgcagcgtt
    10141 ttgctgaact cggttagctt tttgttcccc cacctcgtct acgagatcag aaaattctaa
    10201 ccgcccacgc aaaaaccact tgacagagct tatttcttcg ccctgttgaa gactgtccgc
    10261 acggacaacc tcttcatttc cccgatacat ttcacttact gtaatcattt gtttaataat
    10321 atcaatgtta tcagatttat ccttttcata gtatcctttt tgtttgaaac tcgcaagtac
    10381 ggttctcatc aaatcccttt gcatttccgt caaatcgccg ttttttcagc actatgaaaa
    10441 tcaatgttga gttctttaga cattgttaat ttttttcaac acagagaaca cggagtagca
    10501 cagagtacca cagagaataa gtaattcacg cgtgaatttg atttttaaat catattctga
    10561 tattaaatac actgtaaatg tatgtgtttt gaaaacattt gcaaactgat agctgctaag
    10621 atgtcaatac cttaccacct atcagtttag tacagcagat taacttcatt accggattag
    10681 tttattggta gcattgagtc aatccgctta tttcgttaaa cgaagtaacg atgcgagttt
    10741 atccgttgta ctatatattt caatgagtta aacaaaacgg ctaagatgcc aataccaaaa
    10801 tgcttgacat ctgatttcaa tatcagttat tttgcaccct catttttttt agaggatgca
    10861 ttcaatgatc aaaaaatgcg ttgttttgat cgcgctactc tgtccaaact tacttcagag
    10921 tgcgcccctt tctgagcctg cctctttgag agatagcctg ccacctgagg ctatcagcta
    10981 tctgcgtatt cccaatcctt gggggtttct gactgcccct aaaggcagtg tcttaaatga
    11041 tgccttggca aatgagcagc atgttcagca aatccaaaat ttggaatcgg cgatttatca
    11101 gaatctgttg aatctcagcc aagcggatct ccaccccgct ttgcgctttt ttttccatca
    11161 tttgcgttcc cccatagaag ctgtggcttt actccctgaa catatgccgc cgcatcttgc
    11221 aaatcacctg atttcagcta agctggattt gacttcgatt gaggctttca atcaactcct
    11281 aacacaattg gttgccaaga ctgacgcttt gagtatcgtc aatccgctct caaaagacgg
    11341 ttatggcctt ttaattgtag cgcagatgtt gccgcttttt ctgcattaca atgtgaacac
    11401 ccgaacggtg tatctcatgg gaggcttcac agccactgaa gcgattttta aaaaaaccct
    11461 agccggcctt gcgccggtta cacaccatcc gatgtttgat atggaaaaac aggtggatac
    11521 tagcgcacag gggttttttc agtggatcaa tttccagcgt ttgtcaccta tattgctgaa
    11581 taaaattcac cccgatataa tcagtcaatg gcataaatgg ggcgtgacga gtttgcgtgc
    11641 cgttgcgctg ggttggggtg tcagtgaagg taaagggcgt ttaaagctga tattggatat
    11701 gccacgaact ggctttcgtc aattgtttcc cggtataagc aataacctca ccctaaccgc
    11761 ttctggccag cctcaaaccg tcatttcttt ctcaatccct gccttaacct ggttgacaga
    11821 gtttgagaaa atcgctgatc aagtcttatc acatgatgac gttcaagcgt actacgcttt
    11881 caaaacagaa cttcaaacag aaatgggcta ttcgcttgaa acattactgg gggcactagg
    11941 cccacaaatg ctctttttct ctgatgaagt gggttatttt gtggcctttc aaatcaacaa
    12001 tcgcaacatg atgcagaaag tctttaccgc tttgatgaaa aagtatgatt gggcatctta
    12061 cgaaagccga gaaatcaagg gtaaaacgta tcatcatctg aaaacggcct ttatccaaaa
    12121 agctattgaa gataatccct attttttatc cccttcatcg gccggtaaaa aagcgtttgt
    12181 cttgttttgg acacaattca tttctaacct gaaaacccat tattattggg tagaagaaga
    12241 cggttatctg atttttgcta cactgccgca atttttgctg gatagacaac agtcttcttc
    12301 agcgcgtgtt ccccttcaaa cctggttgaa agaaaaacaa gggcaagata accaatcgtc
    12361 tttgtttttg ttatcaacca ctttttctga gacaccccgt aagctttatc atgcttattt
    12421 atatagcttg gtgttattgg gcgatgtgtt tgagacagaa atcgacttat ttacgctgcc
    12481 aacggcgcgg gaactgagtt tgccgatgca gggcacttac gggatacagt ttgatatatc
    12541 tgattcgcag ttatcactcg aattagtctt tgaaaacaat cccttagagt tcatttttga
    12601 gggcggcatg agtacggtag cgattgccgg tataatggca gctgtggcga ttcctgccta
    12661 taacgattac atgctcaagt cgaaaatctc ggcagggatg aggttattga atacgatgaa
    12721 gacgaaggct gaagtgtttc gtcttgaaga gggccgtttt ccaacggtta aggagcttga
    12781 gatgccaagg cagggtactt acaccaaaaa cctgcgctta cttaaacgga aaaatggtta
    12841 tgccattggg tttaaggatc cggctttgcc gggggtgttg aaactgattt ttaatcacaa
    12901 gactcagcgc tggcgttgta cgcatcagaa tctgcaaaag aagtatctgc cacgtcactg
    12961 ccggggggtg attaaagaac gccctaaaaa gcgcattaaa aagtcgattg gcgatgacaa
    13021 tcggaataag cagcaagtcg caaaagcgct gtctttgttg aatgatttcg caaaacgcgc
    13081 caaagagtat tttgccgttt tgggtactct gccaaccact caagagattg aagatatttg
    13141 gggactcaaa agtcctcaag gcctacatat tcagttgtta gaaacgaaag atggctacta
    13201 taccctattt gaaaaaccgg ctatttcggg tagactgata cttcgcggta atgctaataa
    13261 taggagttgg acgtgtacgc atgacggcat gttggaaagg tatttgccag aagagtgcaa
    13321 atagggaaaa gtgatagccc gctttaaacg gcggttttta tagcatttcc cttttgcgtg
    13381 aaccgaaggt cagcgaagct aaatacctca attagtaggg gcaagctggg gtgttaaatt
    13441 tcaggtacgg gatgactttt tttcacccaa gatttgtagg gtgggtaaac gggcggcaat
    13501 gaactcaata taaacccaga ttgaagccgc ccgtttgccc accatctccc cattaggaat
    13561 aaaaatagag tga
//
