LOCUS       c00298_3300017..        4520 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300017518.a:Ga0185335_1017881.
ACCESSION   c00298_3300017..
VERSION     c00298_3300017..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 08:22:36
            Original ID  :: 3300017518.a:Ga0185335_1017881
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4520
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..711
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     162.9; E-value: 2e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg298_1"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.9e-09,
                     bitscore: 23.5, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="HNNLSATIAVIELSLALNIPRLVFASSAAVYGNPTQLPISEAQLT
                     DPISPYGLQKRVSEQYASLFAKQRGSSFVGLRLFNVFGPRQLPNSQYSGVISIFVAAMQ
                     QGLPLTIYGDGTQTRDFIYVKDVANGFAKALTISLTPGSSLIFNLGTGKSISLMQLVNI
                     LKICIPEWRSQVKFALPRLGDIEHSEADVSSASSLLGFKTQWSVQQALELFITSSKTLM
                     PSGEGSSNREIERN"
     protocluster    1..4520
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[788:4520](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      789..4520
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..4520
                     /SMILES="NC(C(O)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..4520
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             789..4520
                     /NRPS_PKS="Domain: AMP-binding (593-999). E-value:
                     8.2e-114. Score: 372.1. Matches aSDomain:
                     nrpspksdomains_ctg298_2_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1134-1203). E-value: 2.7e-24.
                     Score: 76.9. Matches aSDomain:
                     nrpspksdomains_ctg298_2_PCP.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     179.5; E-value: 2.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg298_2"
                     /sec_met_domain="Condensation (E-value: 8.6e-23, bitscore:
                     67.9, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-125, bitscore:
                     405.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-19, bitscore:
                     57.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.7e-40,
                     bitscore: 125.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMIEQTKSVIGSISVIIPAYNSARFLPEAIESVLRQTYSVFEIIV
                     VDDGSTDETREICEQYPTVTYIYQANQGQIGARNTGLQASKGEYLLFFDSDDCLLPNAV
                     EAGVNCINTHPEVGFVFGNYIFQSINPDGSYTTQEIYDNQHEEANYANILAGKLKLQVA
                     SVLFRRIAVEAVGGFDPKAQDSEDYNLFLRVAREFPIKFHNEVILEYRYNGANISSNPV
                     KMLIATLNSLSLQWNYIQQTGNKEYEVAYELGKKTWTKLFLERLPYEISRDVQAGKYLA
                     ALGILRLILTYDPKLKLIDQEIYEASKRSILSKLRLLPIEPSMAYWKQQLIGAPPLLPL
                     PTDRPRGAEQTFRGDTQSFILAEKLTSALSLLSTDAGVTLSMTLLAAFNTLLYRYTGIE
                     DIIVGSPLVNRDKSSEVFVNAVVLRTDMSENPSFQKLLNRVRKVVLAGEAHQDVPFEIL
                     VEELQLQPDSSYSPLFQVMFAFEEDISFQKIDLSSLTASPWVLENNEGKFDLTLLLEHN
                     SNKLVGKWVYNTDLFNASTIARMNEHFQVLLENIVAHPERPISELRLMTEKERHQLLVE
                     WNNTQSEYPQNKCIHHWFEEQVEHSPDGIALVYENHHLTYRELNNQANQLANYLIDLGV
                     RANVLVGICVERSLEMIVGILGILKAGGAYVPLDPNNPQDRLEYILSDAQVRILVTQST
                     LLDILPVCEQIVCLDTDCQTIAQYPQSNPLGNVTSHDLAYIIYTSGSTGKPKGVLVSHS
                     NVIRLFTATESWYNFHAGDVWTLFHSFAFDFSVWEIWGALFYGGRIVVVPYLVCRDTKA
                     FYKLLVSERVTILNQTPSAFYQLIEVDKCSNLIADLSLRLVIFGGEALKLANLQPWFER
                     HSDRFPQLINMYGITETTVHVTYRPINTADVQASGSLIGRPIPDLQIYLLDRYRQPVPI
                     GVCGEMYVGGAGLAKGYWQRDLLTTERFISNPFSKDPNARLYKSGDLARYLNDGSLEYI
                     GRIDDQVKIRGFRIELGEIESVLSQHPIVEQVLVIAQQNDRGDKHLISYIVHNPEKTPD
                     HSELRRFLHDKLPYYMVPSFFFFLDTMPLTSNGKVDRKALPTPTIGGSKLATVYPKPQT
                     KTEKVLDLNNAPSTSLDTNLSTAINATEEILIGIWEQVLGIQPIGITDDFFELGGHSLL
                     AVSLFAQIEKTFGENLPLATLFKAPTIEQMASFLRQEKPTEELWDCLVPLQTDGSKTPL
                     FCMHGGGFNVLIYRRLAQD"
     CDS_motif       2109..2228
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg298_2_0001"
                     /evalue="4.70E-18"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg298_2"
                     /protein_end="480"
                     /protein_start="440"
                     /score="57.5"
                     /tool="antismash"
                     /translation="RKVVLAGEAHQDVPFEILVEELQLQPDSSYSPLFQVMFAFE"
     aSDomain        2568..3785
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg298_2_AMP-binding.1"
                     /evalue="8.20E-114"
                     /label="ctg298_2_AMP-binding.1"
                     /locus_tag="ctg298_2"
                     /protein_end="999"
                     /protein_start="593"
                     /score="372.1"
                     /specificity="consensus: thr"
                     /tool="antismash"
                     /translation="FEEQVEHSPDGIALVYENHHLTYRELNNQANQLANYLIDLGVRAN
                     VLVGICVERSLEMIVGILGILKAGGAYVPLDPNNPQDRLEYILSDAQVRILVTQSTLLD
                     ILPVCEQIVCLDTDCQTIAQYPQSNPLGNVTSHDLAYIIYTSGSTGKPKGVLVSHSNVI
                     RLFTATESWYNFHAGDVWTLFHSFAFDFSVWEIWGALFYGGRIVVVPYLVCRDTKAFYK
                     LLVSERVTILNQTPSAFYQLIEVDKCSNLIADLSLRLVIFGGEALKLANLQPWFERHSD
                     RFPQLINMYGITETTVHVTYRPINTADVQASGSLIGRPIPDLQIYLLDRYRQPVPIGVC
                     GEMYVGGAGLAKGYWQRDLLTTERFISNPFSKDPNARLYKSGDLARYLNDGSLEYIGRI
                     DDQVKIRG"
     aSModule        2568..4397
                     /complete
                     /domains="nrpspksdomains_ctg298_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg298_2_PCP.1"
                     /locus_tags="ctg298_2"
                     /monomer_pairings="thr -> thr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2754..2795
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg298_2_0002"
                     /evalue="3.70E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg298_2"
                     /protein_end="669"
                     /protein_start="655"
                     /score="19.9"
                     /tool="antismash"
                     /translation="LGILKAGGAYVPLDP"
     CDS_motif       2985..3044
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg298_2_0003"
                     /evalue="6.80E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg298_2"
                     /protein_end="752"
                     /protein_start="732"
                     /score="33.9"
                     /tool="antismash"
                     /translation="AYIIYTSGSTGKPKGVLVSHS"
     CDS_motif       3573..3662
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg298_2_0004"
                     /evalue="8.70E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg298_2"
                     /protein_end="958"
                     /protein_start="928"
                     /score="43.6"
                     /tool="antismash"
                     /translation="PIGVCGEMYVGGAGLAKGYWQRDLLTTERFI"
     CDS_motif       3750..3815
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg298_2_0005"
                     /evalue="8.00E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg298_2"
                     /protein_end="1009"
                     /protein_start="987"
                     /score="40.2"
                     /tool="antismash"
                     /translation="YIGRIDDQVKIRGFRIELGEIES"
     aSDomain        4191..4397
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg298_2_PCP.1"
                     /evalue="2.70E-24"
                     /label="ctg298_2_PCP.1"
                     /locus_tag="ctg298_2"
                     /protein_end="1203"
                     /protein_start="1134"
                     /score="76.9"
                     /tool="antismash"
                     /translation="EEILIGIWEQVLGIQPIGITDDFFELGGHSLLAVSLFAQIEKTFG
                     ENLPLATLFKAPTIEQMASFLRQEK"
ORIGIN
        1 cacaataatc tttcagcaac gatcgctgta attgaacttt ccctggcatt aaatattcct
       61 cggctagttt ttgctagttc agccgctgta tatggaaacc ccacacaatt accaatttcc
      121 gaagcacaac tgacagatcc aatttcaccc tatggcttac aaaaacgtgt tagcgaacaa
      181 tatgccagct tgtttgctaa acagagaggg agttcatttg tcggattacg cttgtttaat
      241 gtctttggtc ccagacaact acctaattcc caatactctg gtgtgatttc catctttgtg
      301 gcagcaatgc aacaaggctt acccttaaca atttatggag atggaacgca gacgcgagat
      361 tttatctacg ttaaggatgt agcaaatggc tttgccaaag ctttaacgat ttcattaaca
      421 cctggctcat ctttaatttt taacttaggt actggaaaat ctatttcttt aatgcagttg
      481 gtcaatattc ttaaaatatg tatacctgag tggcgatcgc aagttaaatt tgcccttccc
      541 cgtctcggag acattgaaca ttcagaagct gatgtctcaa gcgcttcttc gcttttaggc
      601 ttcaaaactc aatggtcagt acagcaggct ctagaacttt ttatcacatc gtctaaaact
      661 ttgatgccgt ccggcgaagg tagcagtaac agagaaattg agagaaattg agaaaaagac
      721 agaattggta ttgaaccgca tttacaagga tctcggctca atatttacta gcaacgaata
      781 tgaaaaatat gatgatagaa caaactaaat ctgtgatcgg tagcatatcg gtaattattc
      841 ctgcctataa tagtgccaga tttttacccg aagcaattga gagtgtcctg agacaaacct
      901 actctgtctt cgagatcatt gtggtagatg atggctcaac tgatgaaact agagaaattt
      961 gcgagcaata cccgacagta acatatatct accaagccaa ccaaggtcag atcggagcgc
     1021 gtaatacagg actacaggct agcaagggag aatatctact cttttttgat agtgatgact
     1081 gtctgttgcc taatgctgta gaggcggggg taaattgcat taatacccat cctgaagttg
     1141 gcttcgtttt tggtaattat attttccaat cgattaaccc tgatggctcg tataccacac
     1201 aagaaatata tgacaatcaa cacgaagaag ctaactatgc aaatattcta gctggaaagc
     1261 taaaacttca agttgccagt gttctttttc gacgtattgc tgttgaagct gtaggtgggt
     1321 tcgacccaaa ggcgcaagat tcagaagact ataatttatt tttacgagtt gctcgtgagt
     1381 ttcccataaa atttcacaat gaagtaattc ttgagtaccg ttataacggt gctaacatat
     1441 cgagtaatcc agttaaaatg ctcatagcta cactaaattc tctgagttta caatggaact
     1501 acattcaaca aactgggaac aaggagtatg aagtagcata tgaacttggt aaaaaaactt
     1561 ggactaaact tttcttagag cggctaccct acgaaataag tagagatgta caagcgggga
     1621 aatatcttgc tgcgcttggt attctccgac tgatattaac ttatgaccca aaattaaagt
     1681 taatcgatca agaaatctac gaagcatcca agcgatccat actctcaaaa ttacgattgt
     1741 tacccattga accctcaatg gcttattgga aacaacaact tataggtgcg ccacctttat
     1801 taccactacc gaccgaccga ccgcgaggag cagaacaaac tttcagaggt gacactcaat
     1861 cctttatact tgctgagaaa ttaacgtcag cactgagttt attgagcaca gacgcaggtg
     1921 ttactctatc tatgaccctg ctagcagcgt tcaatacctt actttaccgt tacacgggta
     1981 ttgaagacat catagttggt tctcccttag tcaatcgcga caagagttcg gaagtttttg
     2041 ttaacgcggt agttttacgt accgatatgt ctgaaaatcc cagtttccag aaattactaa
     2101 atcgagtgcg gaaagtagtt ttagcaggtg aggctcatca agacgtaccg tttgagatct
     2161 tagtagaaga attacaacta cagccagact caagctattc acctctattc caagtaatgt
     2221 tcgcatttga ggaagatatt tcctttcaaa agatcgatct ttcgagtcta accgcaagtc
     2281 cgtgggtatt agaaaataac gaagggaagt tcgatctaac tttattgctc gaacacaaca
     2341 gcaacaaatt ggtagggaag tgggtatata acactgactt attcaatgct agtacaattg
     2401 ctcgaatgaa cgagcatttc caggttttat tggagaatat tgtcgctcat cccgaacgac
     2461 ctatttctga gttacgctta atgactgaaa aagagcgaca tcaattattg gtggaatgga
     2521 ataatactca gagcgaatat ccccaaaata aatgtattca tcactggttt gaagaacagg
     2581 tagagcatag tcctgatggc atagcattag tctatgaaaa ccaccacctc acttatcgag
     2641 agctaaataa tcaagctaat caattagcaa attatctaat tgatttaggg gttagagcga
     2701 atgttttagt tggtatctgt gtagaacgtt ccttagagat gatagtaggg attttaggaa
     2761 ttctcaaggc aggcggagcc tatgtgcctc tagatcctaa taatccccaa gaccgcttag
     2821 aatatatttt aagcgatgcc caagtgcgaa tattggttac tcagtctaca ttgctcgata
     2881 ttttgcctgt ttgcgaacag attgtttgct tggataccga ttgtcaaaca attgctcaat
     2941 atcctcaatc taatccattg ggcaatgtga cgagtcacga cctcgcttat attatttata
     3001 cttctggttc tacaggcaag ccaaaaggag tattagtcag ccattccaat gtaattcgcc
     3061 tatttacagc gactgaatct tggtataact ttcacgcagg agatgtgtgg acattatttc
     3121 actccttcgc ttttgacttt tccgtgtggg aaatatgggg tgccttattt tatggaggac
     3181 gtattgtcgt tgttccctac ctagtgtgtc gagacacaaa agcattctac aaattattgg
     3241 tttctgagcg agttactatt cttaatcaaa ccccatctgc tttttatcaa cttattgaag
     3301 tagataaatg ctccaattta atagcagact taagtttacg actggtcatt tttggtggag
     3361 aggctctgaa gttagctaat ttgcagcctt ggtttgagcg acatagcgac cggtttcccc
     3421 agttgataaa tatgtacgga atcacagaaa ctaccgttca tgttacctat cgtcctataa
     3481 acacagcaga tgttcaagct tctggcagct taattggtcg tccaattcct gacttacaaa
     3541 tttacctttt agatcgctat cgccaacctg taccgatagg tgtctgcgga gaaatgtatg
     3601 ttggcggtgc cgggttagca aaaggctatt ggcagcgcga tctcctgacc acagagagat
     3661 tcatctcaaa tccctttagc aaagacccta atgcacgcct ttataaaagc ggcgacttag
     3721 cacgttactt aaatgacggc agtcttgaat acattgggcg cattgacgat caagttaaaa
     3781 ttcgcggttt ccgaattgaa ttaggcgaaa ttgagtcagt gctgagtcaa catccaatcg
     3841 tcgaacaagt tttggtcata gcacagcaaa acgatcgggg tgacaagcac ttaatctcct
     3901 atattgttca caatcctgaa aagacacccg atcatagtga attgcgccga tttctacacg
     3961 ataaactgcc ctattatatg gtaccgagtt tcttcttttt tttggataca atgcccttaa
     4021 cttctaatgg caaagtcgat cgtaaagctt tacctactcc aacaattggg ggatcgaaat
     4081 tagcaacggt ttatcccaaa cctcaaacta aaactgagaa ggtactcgat ctcaacaatg
     4141 cccccagcac aagtttagat actaacttgt ctacagccat aaatgctaca gaggaaatcc
     4201 ttattggtat ttgggaacaa gttttaggta ttcaacccat aggtatcaca gacgactttt
     4261 ttgaattggg aggacactcc ttgcttgcgg tgagcctatt tgcccagata gagaagacat
     4321 ttggggaaaa tttacccttg gcaactttgt tcaaagcacc gaccattgag caaatggcta
     4381 gctttcttcg ccaggaaaaa ccgacagagg agctttggga ttgtttagta ccattgcaaa
     4441 cagatggctc taaaacaccg ctattttgta tgcatggcgg tggttttaac gttcttatct
     4501 atcgccgatt agcacaagac
//
