LOCUS       c00395_3300017..        7786 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300017518.a:Ga0185335_1008258.
ACCESSION   c00395_3300017..
VERSION     c00395_3300017..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 08:22:36
            Original ID  :: 3300017518.a:Ga0185335_1008258
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7786
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7786
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2951:7034](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(2952..7034)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..7786
                     /SMILES="NC(CS)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7786
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             complement(121..1005)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg395_1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 6.1e-29,
                     bitscore: 89.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQPQPTVSIILVNYNGAEVLPDCINSIEKFLPISDCEIIIVDNA
                     SNDGSPELVAHNPHVNLIKLSDNIGFGAGNNTGARIATGEFLLLLNTDTILTSNILPHL
                     INLIDTHPEVGIIGPKLLNSDGSFQISTSPAIGIKGESQARKLNDDYEKNHNIRAIEQK
                     FQKTQEVDIVVGAAFFMRADLFHTIGGFDEKFFMYFEESDLCQRAQNIGYKILYTPDVS
                     LIHLKGYSIQKAANAMAVEYRRSQIYYYQKHRPLWEQLVLRLYLLYKFSREFVTSANPN
                     CLKILLLALTKIY"
     CDS             complement(1002..1982)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg395_2"
                     /sec_met_domain="Glycos_transf_2 (E-value: 5.6e-21,
                     bitscore: 63.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQDREKIGIVLATYNPNIQYFQKQIHSIQNQTYQNWVCHIVDDCS
                     LPEYQDAITIIADDPRFICHFHSDNLNHYYNFERGLNYCSQDQTITAIAFCDQDDIWQA
                     EKLTILLEKLRSEQALLVHSDLEMIDSHDQTINISAWNFEGRNPEKLTAELLLIRNSVT
                     GCALLFCTSLLPYILPLPQQDKANWHHDWWVAIVAAQMGKIEHIRQPLVRYRLHGSNTV
                     GVMQDAGMFYRELIVWFSKKLRITGKSYLTHRNLSQAFQARFQPQLGITWCNPFDDRRL
                     DFGLGILKLGYKSVHRGYGSEGIALRIWFCKVLFDLKKIRKYYSP"
     CDS             complement(2026..2907)
                     /NRPS_PKS="Domain: NAD_binding_4 (41-159). E-value:
                     1.4e-08. Score: 25.8. Matches aSDomain:
                     nrpspksdomains_ctg395_3_NAD_binding_4.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 76.1;
                     E-value: 5.5e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg395_3"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.4e-115,
                     bitscore: 372.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPKILLIGCHGQLGKELQQILPSTDVVALARPTIDLAQPDTLRQ
                     VIDDIQPQVIVNTAAYTAVDKAESEIELATAINATAPGILAEQTQKLGGFLIHISTDYV
                     FDGSQSHPYRETDPTNPLSIYGQTKLAGEEAIRKNCPNHLILRTAWVYGIHGKGNFVKT
                     MLRLGSEREEIRVVADQIGSPTYTQDLAQAIAHLLPLSTPEIAGTYHYTNSGVISWYDF
                     AIAIFEEAQQLGFPLKVQRVIPITTLEYPTPAHRPAYSVLSSEKISLILGTNPPHWRQG
                     LQQMLKDLFKNR"
     aSDomain        complement(2431..2784)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg395_3_NAD_binding_4.1"
                     /evalue="1.40E-08"
                     /label="ctg395_3_NAD_binding_4.1"
                     /locus_tag="ctg395_3"
                     /protein_end="159"
                     /protein_start="41"
                     /score="25.8"
                     /tool="antismash"
                     /translation="TLRQVIDDIQPQVIVNTAAYTAVDKAESEIELATAINATAPGILA
                     EQTQKLGGFLIHISTDYVFDGSQSHPYRETDPTNPLSIYGQTKLAGEEAIRKNCPNHLI
                     LRTAWVYGIHGKGNF"
     CDS             complement(2952..7034)
                     /NRPS_PKS="Domain: NRPS-COM_Nterm (1-27). E-value: 4.4e-12.
                     Score: 36.8. Matches aSDomain:
                     nrpspksdomains_ctg395_4_NRPS-COM_Nterm.1"
                     /NRPS_PKS="Domain: Condensation_DCL (6-303). E-value:
                     3e-104. Score: 340.0. Matches aSDomain:
                     nrpspksdomains_ctg395_4_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (466-887). E-value:
                     5.4e-103. Score: 336.4. Matches aSDomain:
                     nrpspksdomains_ctg395_4_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (995-1064). E-value: 8.6e-26. Score:
                     81.7. Matches aSDomain: nrpspksdomains_ctg395_4_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1084-1319). E-value:
                     3.9e-31. Score: 100.9. Matches aSDomain:
                     nrpspksdomains_ctg395_4_Thioesterase.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     344.8; E-value: 1.5e-104)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg395_4"
                     /sec_met_domain="Condensation (E-value: 9e-71, bitscore:
                     226.4, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.9e-119, bitscore:
                     385.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.1e-19, bitscore:
                     58.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTAMIEDSYQLSPMQQGMLFNSLVAQSGVDIEQMICLVPEKLEV
                     LAFAQAWQKVVARHPILRTSFDWEGEGEPLQRVHQQLTIPVEQQDWRGLSQKEQSIQLQ
                     AYLQRDRADGFQLNVAPLMRLTLLRLQESTYQLIWTFHHALLDGRSMPVILQEVFAFYD
                     AMLQGSDLQLPQPRPYRDHIQWLQQQDWSTSQSFWRQLLLGFSAPTPLLIDPTPTHKDG
                     FGQQEIRLSLCTTATLQALAQEHQLTLNTLVQGAWALLLSRYSRESDIVFGATRACRHS
                     SVAGAESMVGLLINTVPVRVNVSAEKPLLTMLQELRSQWVAIRDYEHTPLVNIQGWSDV
                     PKGTSLFNSLLVFENSDLNSVLRLSQGDRYKNLQVQLEEQTNFPLTLIGYGEPELLLKL
                     KYDKHSFNDAKIGRMLGHLQTLLSSMATNPTQCLGDLPLLTVQEQQQLQEWNQTQADFS
                     SSLCIHQLFEAQVQRTPLAVAVVFEQEQLTYKELNIRANQLAHCLKQLGVKPGVLVGVY
                     LERSLEMIPAVLGILKAGGAYVPLEPSFPQARIELLLSSLQINCLVTQTDLLASIQELV
                     PQLPTLQHFICLDRAVETSGQVWNRADLDLLNSENLPPSASADDIAYVIFTSGSTGTPK
                     GVVVRHQPVINLIEWVNKTFHVNATDRVLFITSLCFDLSVYDIFGLLAVGGSIRVVSSP
                     DVRDPEALLQILCHEPITFWDSAPPALQQLASLFPTVKSNGSNPQLRLVFMSGDWIPVT
                     LPDALKTTFPGVEVISLGGATEATVWSNYYPIGKVEPDWKSIPYGKPIQNAEYYILDSY
                     LNPCPIGVSGELHIGGVCLASGYLHQSELTAQKFIPNPFSDNPEARLYKTGDLARYFAD
                     GNIEFLGRIDHQVKVRGFRIELGEIESILAQHKSVQDTVILVRDDHQGHKRLVAYVVLH
                     NACATNELRRFLQTKLPEYMVPSVFIAIDFIPLTANGKVDRRALPAPDSARPDLEKAFV
                     APSNTIELQLTEIWQEVLGLEAIGVNDSFFDVGGHSLLAVKLFTKIEKRFGQKLPLATL
                     FQAPTIGQLASILAQKDKSASWSSLVTIVPSRSTKSPLFLVHALGGNVIGYQKIVRYLK
                     DQPVYGLQAQGLDGKQAPHTCVEDMASHYIQEIRTVQATGPYLLGGFSSGGTVAFEMAR
                     QLVAQGERVSLLAMFDTYSPNLYINHPSQFRTLYTYLRTLYQLPLADKWNYLLAKADWF
                     GSMLMGKQSSKYDLWNEHTFAEDANPYNMEFIDALKQATMVDYLPSAYSGRVTLFTTKE
                     VLRWCQYKNDRGWNSLAEQGVEIHEVPGTHLGMLGDPGVQVLAAKLTACLEQAQAQPRL
                     SIVTTFIESVKVKVSSN"
     aSDomain        complement(3078..3782)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg395_4_Thioesterase.1"
                     /evalue="3.90E-31"
                     /label="ctg395_4_Thioesterase.1"
                     /locus_tag="ctg395_4"
                     /protein_end="1319"
                     /protein_start="1084"
                     /score="100.9"
                     /tool="antismash"
                     /translation="PLFLVHALGGNVIGYQKIVRYLKDQPVYGLQAQGLDGKQAPHTCV
                     EDMASHYIQEIRTVQATGPYLLGGFSSGGTVAFEMARQLVAQGERVSLLAMFDTYSPNL
                     YINHPSQFRTLYTYLRTLYQLPLADKWNYLLAKADWFGSMLMGKQSSKYDLWNEHTFAE
                     DANPYNMEFIDALKQATMVDYLPSAYSGRVTLFTTKEVLRWCQYKNDRGWNSLAEQGVE
                     IHEVPGTHLGMLGD"
     aSModule        3078..7016
                     /complete
                     /domains="nrpspksdomains_ctg395_4_Condensation_DCL.1"
                     /domains="nrpspksdomains_ctg395_4_AMP-binding.1"
                     /domains="nrpspksdomains_ctg395_4_PCP.1"
                     /domains="nrpspksdomains_ctg395_4_Thioesterase.1"
                     /final_module
                     /locus_tags="ctg395_4"
                     /monomer_pairings="cys -> cys"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(3531..3605)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0012"
                     /evalue="1.60E-12"
                     /label="NRPS-te1"
                     /locus_tag="ctg395_4"
                     /protein_end="1168"
                     /protein_start="1143"
                     /score="39.7"
                     /tool="antismash"
                     /translation="QATGPYLLGGFSSGGTVAFEMARQLV"
     aSDomain        complement(3843..4049)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg395_4_PCP.1"
                     /evalue="8.60E-26"
                     /label="ctg395_4_PCP.1"
                     /locus_tag="ctg395_4"
                     /protein_end="1064"
                     /protein_start="995"
                     /score="81.7"
                     /tool="antismash"
                     /translation="ELQLTEIWQEVLGLEAIGVNDSFFDVGGHSLLAVKLFTKIEKRFG
                     QKLPLATLFQAPTIGQLASILAQKD"
     CDS_motif       complement(4344..4409)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0011"
                     /evalue="1.40E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg395_4"
                     /protein_end="897"
                     /protein_start="875"
                     /score="39.4"
                     /tool="antismash"
                     /translation="FLGRIDHQVKVRGFRIELGEIES"
     aSDomain        complement(4374..5636)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg395_4_AMP-binding.1"
                     /evalue="5.40E-103"
                     /label="ctg395_4_AMP-binding.1"
                     /locus_tag="ctg395_4"
                     /protein_end="887"
                     /protein_start="466"
                     /score="336.4"
                     /specificity="consensus: cys"
                     /tool="antismash"
                     /translation="FEAQVQRTPLAVAVVFEQEQLTYKELNIRANQLAHCLKQLGVKPG
                     VLVGVYLERSLEMIPAVLGILKAGGAYVPLEPSFPQARIELLLSSLQINCLVTQTDLLA
                     SIQELVPQLPTLQHFICLDRAVETSGQVWNRADLDLLNSENLPPSASADDIAYVIFTSG
                     STGTPKGVVVRHQPVINLIEWVNKTFHVNATDRVLFITSLCFDLSVYDIFGLLAVGGSI
                     RVVSSPDVRDPEALLQILCHEPITFWDSAPPALQQLASLFPTVKSNGSNPQLRLVFMSG
                     DWIPVTLPDALKTTFPGVEVISLGGATEATVWSNYYPIGKVEPDWKSIPYGKPIQNAEY
                     YILDSYLNPCPIGVSGELHIGGVCLASGYLHQSELTAQKFIPNPFSDNPEARLYKTGDL
                     ARYFADGNIEFLGRIDHQVKVRG"
     CDS_motif       complement(4497..4586)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0010"
                     /evalue="8.00E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg395_4"
                     /protein_end="846"
                     /protein_start="816"
                     /score="43.7"
                     /tool="antismash"
                     /translation="PIGVSGELHIGGVCLASGYLHQSELTAQKFI"
     CDS_motif       complement(5112..5171)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0009"
                     /evalue="1.40E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg395_4"
                     /protein_end="641"
                     /protein_start="621"
                     /score="33.0"
                     /tool="antismash"
                     /translation="AYVIFTSGSTGTPKGVVVRHQ"
     CDS_motif       complement(5412..5450)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0008"
                     /evalue="2.50E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg395_4"
                     /protein_end="541"
                     /protein_start="528"
                     /score="17.4"
                     /tool="antismash"
                     /translation="LGILKAGGAYVPLE"
     CDS_motif       complement(5970..6074)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0007"
                     /evalue="2.20E-17"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="ctg395_4"
                     /protein_end="355"
                     /protein_start="320"
                     /score="55.5"
                     /tool="antismash"
                     /translation="VAIRDYEHTPLVNIQGWSDVPKGTSLFNSLLVFENS"
     aSDomain        complement(6126..7016)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg395_4_Condensation_DCL.1"
                     /domain_subtype="Condensation_DCL"
                     /evalue="3.00E-104"
                     /label="ctg395_4_Condensation_DCL.1"
                     /locus_tag="ctg395_4"
                     /protein_end="303"
                     /protein_start="6"
                     /score="340.0"
                     /tool="antismash"
                     /translation="EDSYQLSPMQQGMLFNSLVAQSGVDIEQMICLVPEKLEVLAFAQA
                     WQKVVARHPILRTSFDWEGEGEPLQRVHQQLTIPVEQQDWRGLSQKEQSIQLQAYLQRD
                     RADGFQLNVAPLMRLTLLRLQESTYQLIWTFHHALLDGRSMPVILQEVFAFYDAMLQGS
                     DLQLPQPRPYRDHIQWLQQQDWSTSQSFWRQLLLGFSAPTPLLIDPTPTHKDGFGQQEI
                     RLSLCTTATLQALAQEHQLTLNTLVQGAWALLLSRYSRESDIVFGATRACRHSSVAGAE
                     SMVGLLINTVPVRVNVS"
     CDS_motif       complement(6135..6230)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0006"
                     /evalue="7.30E-16"
                     /label="C5_DCL_263-294"
                     /locus_tag="ctg395_4"
                     /protein_end="300"
                     /protein_start="268"
                     /score="50.6"
                     /tool="antismash"
                     /translation="DIVFGATRACRHSSVAGAESMVGLLINTVPVRV"
     CDS_motif       complement(6465..6503)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0005"
                     /evalue="1.50E-03"
                     /label="C4_DCL_171-183"
                     /locus_tag="ctg395_4"
                     /protein_end="190"
                     /protein_start="177"
                     /score="11.2"
                     /tool="antismash"
                     /translation="PYRDHIQWLQQQDW"
     CDS_motif       complement(6549..6614)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0004"
                     /evalue="1.10E-09"
                     /label="C3_DCL_135-156"
                     /locus_tag="ctg395_4"
                     /protein_end="162"
                     /protein_start="140"
                     /score="30.8"
                     /tool="antismash"
                     /translation="FHHALLDGRSMPVILQEVFAFYD"
     CDS_motif       complement(6669..6728)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0003"
                     /evalue="4.30E+01"
                     /label="C5_dual_260-291"
                     /locus_tag="ctg395_4"
                     /protein_end="122"
                     /protein_start="102"
                     /score="-2.2"
                     /tool="antismash"
                     /translation="LQAYLQRDRADGFQLNVAPLM"
     CDS_motif       complement(6837..6938)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0002"
                     /evalue="9.40E-12"
                     /label="C2_DCL_024-062"
                     /locus_tag="ctg395_4"
                     /protein_end="66"
                     /protein_start="32"
                     /score="37.2"
                     /tool="antismash"
                     /translation="EQMICLVPEKLEVLAFAQAWQKVVARHPILRTSFD"
     aSDomain        complement(6954..7031)
                     /aSDomain="NRPS-COM_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg395_4_NRPS-COM_Nterm.1"
                     /evalue="4.40E-12"
                     /label="ctg395_4_NRPS-COM_Nterm.1"
                     /locus_tag="ctg395_4"
                     /protein_end="27"
                     /protein_start="1"
                     /score="36.8"
                     /tool="antismash"
                     /translation="KTAMIEDSYQLSPMQQGMLFNSLVAQS"
     CDS_motif       complement(6969..7007)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg395_4_0001"
                     /evalue="1.90E-04"
                     /label="C1_DCL_004-017"
                     /locus_tag="ctg395_4"
                     /protein_end="22"
                     /protein_start="9"
                     /score="13.5"
                     /tool="antismash"
                     /translation="YQLSPMQQGMLFNS"
ORIGIN
        1 ttgctgatga ccataaatct ttacgtggca agggtttaag tgccttaaaa agagtaaact
       61 ttagttgcaa gatgtgacta atttactgtt tttaccataa aagaagcggt agagccaaaa
      121 ttagtatatc ttggtaagtg ctaatagtag gattttgaga caattaggat ttgcggaagt
      181 gacaaactca cgcgagaatt tatacaatag gtaaaggcgt aatactaatt gttcccacaa
      241 aggtcgatgt ttttggtagt agtaaatttg gctacgccta tattcaacag ccattgcatt
      301 tgcggctttc tgaattgagt atccttttaa gtgaatcaga gatacatccg gtgtgtatag
      361 tattttatat cctatatttt gtgctctttg acataaatct gactcttcaa aatacataaa
      421 aaacttttcg tcaaatccac ctatagtatg aaataaatct gcacgcataa aaaaagcagc
      481 tccaacaaca atatctactt cttgagtttt ttgaaacttc tgctcaatcg cacgaatatt
      541 atgatttttc tcataatcat cattcaattt acgcgcttgc gactcacctt ttatccctat
      601 tgctggtgaa gtggaaattt gaaaactacc atctgaatta agtaatttag gtccaataat
      661 gccgacttca ggatgtgtgt ctatgaggtt aattagatgc ggtaaaatat tactagtaag
      721 aattgtatca gtatttaata ataataaaaa ttctcctgta gctatgcgtg cgccggtatt
      781 atttcctgca ccaaagccaa tgttatctga taatttaatt aagttgacat gaggattatg
      841 tgcaactaat tcaggactac cgtcattaga tgcattgtca actataatga tttcgcaatc
      901 tgaaatcggc agaaattttt ctatagagtt tatacaatct ggtaatacct ctgctccatt
      961 gtagttgaca aggattattg atacggtagg ttgtggctgt ttcatggact gtaatatttt
     1021 cggatttttt ttaggtcgaa taaaaccttg caaaaccaaa ttcgcagtgc aattccttcc
     1081 gaaccataac ctctgtgtac acttttataa ccgagtttta aaatacctaa accaaagtct
     1141 aatcggcgat catcaaatgg attgcaccaa gttatcccta attgtggctg gaatctagct
     1201 tgaaacgctt gactcagatt gcgatgggtt aaatagcttt tacctgtaat gcgtaatttt
     1261 ttactaaacc aaacaattaa ctcgcggtag aacattcctg catcttgcat gactccaact
     1321 gtatttgaac cgtggagtcg gtaacggact aaaggttggc gaatatgctc aatcttaccc
     1381 atttgcgcgg caacaattgc tacccaccag tcgtgatgcc aattagcttt gtcttgttga
     1441 ggtaagggca ggatataagg taataaagaa gtacagaata agagggcgca tccagtcaca
     1501 ctgttacgaa ttagtaataa ttcagcagta agtttttcgg gattgcgtcc ttcaaaattc
     1561 caggctgaaa tatttatagt ttggtcgtga ctgtcaatca tttctagatc ggaatggact
     1621 aatagcgctt gttcggaacg taatttttct aataatatag ttaatttttc ggcttgccaa
     1681 atatcatctt gatcgcagaa agcgatcgct gtgattgttt ggtcttgact acagtaattt
     1741 aacccgcgtt caaagttata gtagtgattg agattatcac tatgaaaatg gcagataaag
     1801 cgtgggtcat cagcgataat ggtgatagca tcctgatatt ctggtagaga acagtcatcc
     1861 acaatatgac aaacccagtt ttggtaagtt tgattttgaa tagaatggat ttgtttttgg
     1921 aagtattgaa tattcggatt ataagttgct aaaacaatcc caatcttttc tcgatcctgc
     1981 atagttaaat atcaacaata tatgagtagg agcgatgtac gcccattaac gattcttgaa
     2041 caaatctttc agcatctgct gaagtccttg tcgccaatgg gggggattag ttcctaaaat
     2101 tagagatatt ttttcagagg agaggacgga ataagcaggg cgatgagcgg gggtgggata
     2161 ttctagggtg gtgatgggga tgacgcgttg gactttgaga gggaagccta gttgttgggc
     2221 ttcttcaaag atggcgatcg caaagtcata ccagctgatc acaccactgt tggtatagtg
     2281 atatgtgcca gcaatttctg gggttgacaa gggtagaaga tgcgcgatcg cttgggctaa
     2341 atcttgagta taagttgggc taccaatttg gtcggcgact acacggattt cttctctttc
     2401 gcttccgagt ctcagcattg tcttgacaaa attaccttta ccatgaatgc cataaaccca
     2461 agctgtacgg agaatcaagt gatttggaca atttttacga attgcttctt cgccagctag
     2521 tttggtttga ccgtaaatac ttagcggatt ggttgggtcg gtttcgcgat aaggatggct
     2581 ttggctacca tcaaaaacgt aatcagtgga gatgtgaatt aggaatcctc ccaatttttg
     2641 agtctgttcg gcgaggattc cgggcgctgt ggcgttaatg gctgtggcga gttctatttc
     2701 gctttccgct ttatccactg ctgtatatgc tgctgtattg acaatcacct gaggttggat
     2761 gtcgtcaatg acttggcgga gggtgtcagg ttgggcgagg tcgatagtag gacgggcgag
     2821 ggcgacgacg tcggttgagg gcaatatttg ttgcaattct ttacctaact gaccgtgaca
     2881 gccaatcagc aaaatttttg gactcatggg gttgtacaaa aagatagcga tcgcaggcta
     2941 gcatacttaa gctaattaga gctaactttt acttttaccg actcgataaa agttgtcaca
     3001 atactcaatc taggttgagc ctgcgcctgc tctaaacaag ccgtcaattt tgctgcgagg
     3061 acttgcacac cgggatcgcc aagcattccg agatgtgtac ctggtacttc atggatttct
     3121 actccttgtt cagccagact attccagccg cgatcgtttt tgtactgaca ccacctcaac
     3181 acctctttag tggtaaataa agttacccga ccagagtagg ctgacggtag atagtccacc
     3241 attgttgcct gcttgagagc gtcaatgaat tccatattat aaggattggc atcctcagca
     3301 aaagtgtgct cattccacag gtcatacttg ctactttgtt tccccattaa cattgaccca
     3361 aaccaatccg ctttagcgag caaataattc catttatctg ccaacggtag ttgataaagt
     3421 gtacgcaagt atgtgtataa cgtccggaat tgtgagggat gatttatata cagattaggg
     3481 ctataggtat caaacatggc aagtaaagat acccgctccc cttgagcaac caactgccga
     3541 gccatttcaa aagcaactgt cccaccacta gaaaaaccac ccaacagata gggacccgta
     3601 gcttgaacag tccgaatctc ttgaatatag tgcgatgcca tatcctcaac acatgtgtga
     3661 ggagcctgtt tgccatctag cccttgtgct tggagtccat atacaggttg atctttgagg
     3721 taacgtacta tcttttggta gccaatgaca ttaccaccta gcgcatgaac caagaataag
     3781 ggactttttg tactgcggct gggcacaatc gtgactagag aagaccaaga agctgacttg
     3841 tctttctggg cgagaatgct ggctaactgc ccaattgtcg gtgcttgaaa caaagtcgct
     3901 aagggaagtt tttgcccaaa tctcttttcg attttggtga acaatttcac cgctagcagc
     3961 gagtgtcctc ccacatcgaa gaaactatcg ttgactccaa ttgcctcaag acctaaaacc
     4021 tcttgccaaa tctcggttaa ctggagttct attgtattac taggagcaac aaaggctttt
     4081 tcgagatcgg gtcttgcgga gtcaggtgcc ggtagggcgc ggcggtctac tttaccatta
     4141 gctgtgagtg ggataaagtc aatcgctatg aagacagaag gcaccatata ctctggcaat
     4201 tttgtttgta aaaaccgccg caattcattc gttgcacacg cgttatggag caccacatat
     4261 gctaccagcc gtttatgtcc ttgatgatca tcccggacta agatgacagt gtcctgcact
     4321 gatttatgtt gagcaagtat gctctcaatt tctcctaact caatgcggaa tccgcgaacc
     4381 ttgacttgat gatcaattcg accgaggaat tcaatattgc catcagcaaa atagcgggct
     4441 aaatctccag tcttatagag acgggcttca ggattgtcgc taaaaggatt aggaatgaac
     4501 ttttgtgccg ttaattcact ttgatgcaaa tagccagaag caagacagac tccaccaata
     4561 tgcaactctc cagaaacgcc aattgggcaa ggattgagat aagagtccaa aatgtaatat
     4621 tcagcatttt ggattggttt gccataagga atgctcttcc aatctggctc tactttgcca
     4681 ataggataat aattagacca aactgttgct tctgttgctc cacctaggct gattacttcc
     4741 actccaggga aggtggtttt gagcgcatcc ggtagcgtga caggtatcca atcaccgctc
     4801 ataaaaacta ggcgtagttg agggttactc ccattggatt tgactgttgg gaacaaactt
     4861 gctagttgct gtagtgctgg cggggctgaa tcccaaaagg taattggctc gtgacaaagg
     4921 atctgtaata aagcttcggg atcgcggaca tctgggctag acacaacgcg aatcgagcca
     4981 cctaccgcta aaagtccgaa aatgtcatac actgacaggt cgaaacacaa agatgtgata
     5041 aataacactc tgtcagtagc attgacatga aaggttttgt tcacccactc gatgagattg
     5101 attacaggtt gatgacgtac cactactcct tttggtgtgc ctgtagagcc agaggtaaaa
     5161 attacataag caatatcgtc tgcacttgca gatgggggca aattttcact gttgagtagg
     5221 tcaaggtcgg cacgattcca cacttgtccc gatgtttcga cagcacgatc taggcaaatg
     5281 aagtgttgca gtgtaggaag ttgtggtact aactcctgaa tacttgcaag taaatcagtc
     5341 tgcgtcacta gacaattaat ttgtagagag gaaaggagta attcaatgcg tgcttgagga
     5401 aaactcggtt ctagcggcac atatgcacct cctgctttca aaattcctag tactgctgga
     5461 atcatctcta atgagcgctc taaatacacg cccaccagca cccctggttt gactcctaat
     5521 tgtttgaggc agtgtgctag ctgattcgct ctgatgttta gttctttgta ggtaagttgc
     5581 tcttgctcaa agacgactgc aacagctaat ggtgtccttt gtacctgtgc ctcaaacagt
     5641 tgatggatac aaagcgaaga agagaaatcg gcttgtgtct gattccactc ctgcagttgc
     5701 tgttgttctt gtaccgtcaa caatggtaaa tctcccaaac actgcgtggg gttagtcgcc
     5761 atactcgaca ataaggtttg cagatgtcct agcatccgac cgattttggc atcgttaaag
     5821 ctgtgcttgt cgtatttgag tttgagtaaa agttctggct cgccgtaacc aatcaatgtc
     5881 agcggaaagt tggtttgttc ttctaactgc acttgcagat ttttgtacct gtcaccctgg
     5941 gacaagcgca aaactgaatt taagtcggaa ttttcaaata ccaacagact gttaaacagg
     6001 gacgttcctt tgggaacatc actccaacct tgaatattga ctaatggggt gtgttcgtag
     6061 tctcgtattg ctacccattg cgatcgcagt tcttgaagca ttgtcaagag tggtttttct
     6121 gcggacacgt tgacccggac tggcacagtg ttaatcaaca gtccgaccat cgactccgcc
     6181 ccagctacag atgaatgccg acaggctctg gtagcaccaa agacaatatc gctttcccga
     6241 ctataacgac tgagcaacaa tgcccaagcc ccctgtacca atgtattgag ggtgagttga
     6301 tgttcttggg ctaacgcttg caatgttgca gtggtacaga gagataatcg gatttcttgc
     6361 tgtccaaaac cgtctttgtg agtaggggtt gggtctatta gtaagggtgt tggggcgcta
     6421 aagccgagca ataactgccg ccaaaagctt tgcgatgttg accaatcttg ttgctgtaac
     6481 cattggatgt ggtctcgata tggacgcggt tgtgggagtt gcaagtcaga tccttgaagc
     6541 atcgcgtcat aaaaggcaaa gacttcttgg agaatcaccg gcattgaacg accatctagt
     6601 aaggcatggt ggaaagtcca aattaattgg taagtagatt cttgtaggcg aagcagggta
     6661 aggcgcatta atggggcaac attgagctgg aaaccatctg cgcgatcgcg ttgcagatag
     6721 gcttgcaact ggattgattg ttctttttgt gacaagccac gccaatcttg ctgttccacg
     6781 ggaatcgtga gttgctgatg cacgcgttgc agcggttcgc cctcaccttc ccaatcaaag
     6841 ctggttctta aaattggatg tctggcaaca actttctgcc atgcttgtgc aaatgccaat
     6901 acctcaagtt tttctggcac taaacaaatc atctgctcaa tatccacccc agattgagcc
     6961 actaagctat taaacagcat tccttgttgc attggagaaa gctgatatga atcttcgatc
     7021 attgctgttt tcatggttgg ttctattttt ttaagtttta atcacaaact tgtctgacta
     7081 gttagtcaaa ctaaaatgcc aaattttgta gcactttact taaaaaaatc agtaaatatc
     7141 gctaacaaaa ttcataacgt cttgctgcgt ttatgttgaa acaggtaatt caactacagt
     7201 tgagcaaagc tcaagagaca acgcaggaat tgatgagact tcttgctctc attcttcttt
     7261 gcgtctaacg ctaacagtgc gctaatgtgc ctaacggcaa cgccagtata ttccgcaaga
     7321 caaaaaacat ctacataaga ggtttttcta tctctcgcca acgctctaag gtgaatttat
     7381 gtaacttatt tattgacgaa aacgctagtt catgtcaagg agaaatcagg atttacgatt
     7441 tcattccaat gggaacgagt gcctaagata gagcctgtca ccctgtaatg cattgttatt
     7501 tatgtataga agatggtata cggataatta tacgtaagct atacaaagtt tagttattag
     7561 ctttatattt ttttgatgaa ttttatatgt taatcgggaa gtagtttatt tgtatttatg
     7621 aatgttaagt tatctgtatt ttggacaaca ttgtattatt aggcttttca gtacttgtta
     7681 tgcttaacta tagctaaaat gccagtttaa caagcatctt acacggaaat tcttaaagct
     7741 tctaaatcca tagccggaac gttttattag cttaagttta ttatta
//
