LOCUS       c00398_3300017..       11063 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300017518.a:Ga0185335_1005115.
ACCESSION   c00398_3300017..
VERSION     c00398_3300017..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 08:22:36
            Original ID  :: 3300017518.a:Ga0185335_1005115
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11063
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11063
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4296:6990](-)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(4297..6990)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..11063
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11063
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             2..1270
                     /locus_tag="ctg398_1"
                     /transl_table=11
                     /translation="LASEITELLKKNNLGVTTPSRGENGKPGTSSTPGTKIPNLEQQQY
                     FANVTTKVILPLFKQRQKPFVMVYWSRDPDGTQHNQGDSLNSLTPGINGPTSLAARKNV
                     DQNLAQLRSALQELGLADSTNIFIAADHGFSTISKESKTSYAATLAYPDVPDGFLPPGF
                     LGIDIANELKQPLKDPDKENALIDPKLGKFSKNGLIDQNTQSPEIVIAANGGSDLIYLP
                     KDANKKVLANRIVGFLLKQDYISGLFIDDPLGPIPGTLPMSTIGLKGASRTPTPSIVVN
                     FKSFDTGCGNPTLCGAEIGDTGLQQGQGMHGSFSRADTYNFMAAIGPDFKAGYVDQAPV
                     GNADVAVTLTKVLNLKVTGRGKLVGRVLNETLVKGPNDVAFKSQTLESPTAANGLKTIL
                     KYQTVGNTRCFDVAGFPGRTLGL"
     CDS             1364..1942
                     /locus_tag="ctg398_2"
                     /transl_table=11
                     /translation="MIAIPQQPQKMTIAEYFAWEPQQDVRYEYVNGEVFAMTGGTIPHN
                     DIALNLYTALRPHLRDRGCRVNVSDVKVQVSPHSPYYYPDVIVSCDPQDLNARKFIQYP
                     KLIVEVLSPGTSAKDRGEKFFDYQTIPTLQEYILIDSEKISVERYSRGEGRMWLYYPYI
                     DGDIITLSSIEFECPIELLYEGVVLGTEE"
     CDS             2045..2626
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 92; E-value: 6.6e-28)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg398_3"
                     /sec_met_domain="p450 (E-value: 6.9e-22, bitscore: 67.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSHLHPPGSSGLPILGETLSFAFDDNFIEKRYRQYGSIFKTHII
                     GRPTVVMVGPEAVEFVLSSHMDNFSWREGWPDTFKILLGESLFLQDGEEHRQKRRLMMP
                     ALHGPALSQYVGKMEAITREYLNKWQEKQEFTWLEEFKQLTFDIASQLLLGTNPGAESV
                     RLSNLFTTLTNGLFALNPLRLPVTKLGKAN"
     CDS             2729..3403
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 211; E-value: 5.5e-64)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg398_4"
                     /sec_met_domain="p450 (E-value: 3.4e-57, bitscore: 183.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LLIQAKDEDGNSLSERELVFQSVLLLFAGHETTTSMLTWLCVELA
                     RHPKVLQRARAEQLQLQQHGELNLEQLGQMPYLEQVLWEVERLHPPVGGGFRGVVKEFE
                     FKGFHVPAGWMALYSIIGTHGMTEIYPEPERFDPDRFQHKQRPFSLIGFGGGPRVCIGI
                     AFAKMEMKIVAAQLLRGYQWEILPNQSLEQVRIPTNRPKDGLRVRFQSLTSHKHTISPP
                     VR"
     CDS             complement(3441..4166)
                     /locus_tag="ctg398_5"
                     /transl_table=11
                     /translation="MIINRIINRISNFSLITSPPPHKKTLGLDNRLYDYLLSASLREPD
                     VLRQLRQETASHPQAMMQIAPEQGQFMALLVQLMGAVKTLEVGVFTGYSTLSVALALPP
                     HGKIIALDVSEEYTAIAQRYWQQAGVADKIDLRLAPAMDSLDQLLASGTAETFDFVFID
                     ADKENYDGYYERALQLVRPGGLIAVDNVLWYGNVADPQSQDEYTQAIRALNQKIRHDER
                     VTISLVPISDGLTLCTKRP"
     CDS             complement(4297..6990)
                     /NRPS_PKS="Domain: AMP-binding (36-431). E-value: 1.3e-103.
                     Score: 338.4. Matches aSDomain:
                     nrpspksdomains_ctg398_6_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (539-607). E-value: 1.3e-23. Score:
                     74.8. Matches aSDomain: nrpspksdomains_ctg398_6_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (632-883). E-value:
                     1.2e-34. Score: 112.5. Matches aSDomain:
                     nrpspksdomains_ctg398_6_Thioesterase.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     337.1; E-value: 2.5e-102)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg398_6"
                     /sec_met_domain="AMP-binding (E-value: 3.1e-107, bitscore:
                     348.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.1e-16, bitscore:
                     49.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVSKIHLQEWNQAEKPLVHSYSSQNESEDLCIHQLFEAQVERSP
                     EEVAVVFGVNHLTYQALNSRANQLARYLRTVGVGPEVRVGLCIQPSLELAIGLLAILKA
                     GGVYVPLDSTYPQERLTFLFNQSQLAVLLTQQQILANLPPYAGVTICLDSESFAKEEDT
                     NLVNQVTAHHAAYVVYTSGTTGNPKGVVAEHGNLRNYILATQERFQFDHQEAFPCIARF
                     SFSISLFELLSPLMVGGRAVIFTRDNVLDIAYVVSQLEHLTNLHTVPSLMRQIVNFIQE
                     NHLEPTRYNLKRVFIGGDLIPPNLIEEMKAIFSGADIYTLYGCSEVTTLCLSYKVPTDT
                     KFDKRIVGKPLNNVSLRLYDEQQLVPVGSKGEIYIGGAGVTRGYLHQPELTAQKFVTID
                     NERFCKTGDWGRYLPDGNIEFIGRADFQIKIRGIRIELGEIEAALVQHPQIQQVVVVAN
                     NDEGDERQLVAYVVTTTATTASVLRTYLRAKLPLEMIPKVFVLMDSLPLNPNGKLDRGS
                     LPALADARRLPESISVAPRDELEIQLAKIWEKVLGIQPIGVQDNYFDLGGNSLQALRLF
                     AQIDQKFGKKLPLSTLLKSGTVEALANTIRQIEIPALPEDEAPWSSLVPIRPHGDKPPL
                     FCIHAAGGNILSYRELFLHLPHLPVYALQAKGLDGKPPLTRVEDIASDYIKEIQTVQPT
                     GPYFLGGHSFGGIVAYEMAQQLLSQGEKIGLLFVMDTSAPNAERRLPFSQRIQLHRSKL
                     FQGGLTYLRQKLKGWTTWQTEMFTYKLQKIATSYYLRFGLTLPRELHSLRMGEASAEAF
                     AAYVMQAYPGKLTLFMVDDEVREAGEGFDYDPNLGWNKLVGSLLDVHLVPGDHNSLLSA
                     PHVQVLAEKLQDCLDRAITASEEVKN"
     aSDomain        complement(4342..5094)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg398_6_Thioesterase.1"
                     /evalue="1.20E-34"
                     /label="ctg398_6_Thioesterase.1"
                     /locus_tag="ctg398_6"
                     /protein_end="883"
                     /protein_start="632"
                     /score="112.5"
                     /tool="antismash"
                     /translation="PPLFCIHAAGGNILSYRELFLHLPHLPVYALQAKGLDGKPPLTRV
                     EDIASDYIKEIQTVQPTGPYFLGGHSFGGIVAYEMAQQLLSQGEKIGLLFVMDTSAPNA
                     ERRLPFSQRIQLHRSKLFQGGLTYLRQKLKGWTTWQTEMFTYKLQKIATSYYLRFGLTL
                     PRELHSLRMGEASAEAFAAYVMQAYPGKLTLFMVDDEVREAGEGFDYDPNLGWNKLVGS
                     LLDVHLVPGDHNSLLSAPHVQVLAEKLQDC"
     aSModule        4342..6882
                     /complete
                     /domains="nrpspksdomains_ctg398_6_AMP-binding.1"
                     /domains="nrpspksdomains_ctg398_6_PCP.1"
                     /domains="nrpspksdomains_ctg398_6_Thioesterase.1"
                     /final_module
                     /locus_tags="ctg398_6"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(4843..4917)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg398_6_0007"
                     /evalue="8.40E-16"
                     /label="NRPS-te1"
                     /locus_tag="ctg398_6"
                     /protein_end="716"
                     /protein_start="691"
                     /score="50.1"
                     /tool="antismash"
                     /translation="QPTGPYFLGGHSFGGIVAYEMAQQLL"
     CDS_motif       complement(5062..5091)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg398_6_0006"
                     /evalue="1.90E-03"
                     /label="NRPS-beforete1"
                     /locus_tag="ctg398_6"
                     /protein_end="643"
                     /protein_start="633"
                     /score="11.2"
                     /tool="antismash"
                     /translation="PLFCIHAAGGN"
     aSDomain        complement(5170..5373)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg398_6_PCP.1"
                     /evalue="1.30E-23"
                     /label="ctg398_6_PCP.1"
                     /locus_tag="ctg398_6"
                     /protein_end="607"
                     /protein_start="539"
                     /score="74.8"
                     /tool="antismash"
                     /translation="EIQLAKIWEKVLGIQPIGVQDNYFDLGGNSLQALRLFAQIDQKFG
                     KKLPLSTLLKSGTVEALANTIRQI"
     CDS_motif       complement(5554..5586)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg398_6_0005"
                     /evalue="7.10E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg398_6"
                     /protein_end="479"
                     /protein_start="468"
                     /score="-2.5"
                     /tool="antismash"
                     /translation="AYVVTTTATTAS"
     CDS_motif       complement(5668..5733)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg398_6_0004"
                     /evalue="2.70E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg398_6"
                     /protein_end="441"
                     /protein_start="419"
                     /score="35.4"
                     /tool="antismash"
                     /translation="FIGRADFQIKIRGIRIELGEIEA"
     aSDomain        complement(5698..6882)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg398_6_AMP-binding.1"
                     /evalue="1.30E-103"
                     /label="ctg398_6_AMP-binding.1"
                     /locus_tag="ctg398_6"
                     /protein_end="431"
                     /protein_start="36"
                     /score="338.4"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FEAQVERSPEEVAVVFGVNHLTYQALNSRANQLARYLRTVGVGPE
                     VRVGLCIQPSLELAIGLLAILKAGGVYVPLDSTYPQERLTFLFNQSQLAVLLTQQQILA
                     NLPPYAGVTICLDSESFAKEEDTNLVNQVTAHHAAYVVYTSGTTGNPKGVVAEHGNLRN
                     YILATQERFQFDHQEAFPCIARFSFSISLFELLSPLMVGGRAVIFTRDNVLDIAYVVSQ
                     LEHLTNLHTVPSLMRQIVNFIQENHLEPTRYNLKRVFIGGDLIPPNLIEEMKAIFSGAD
                     IYTLYGCSEVTTLCLSYKVPTDTKFDKRIVGKPLNNVSLRLYDEQQLVPVGSKGEIYIG
                     GAGVTRGYLHQPELTAQKFVTIDNERFCKTGDWGRYLPDGNIEFIGRADFQIKIRG"
     CDS_motif       complement(5806..5895)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg398_6_0003"
                     /evalue="1.40E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg398_6"
                     /protein_end="395"
                     /protein_start="365"
                     /score="49.4"
                     /tool="antismash"
                     /translation="PVGSKGEIYIGGAGVTRGYLHQPELTAQKFV"
     CDS_motif       complement(6409..6468)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg398_6_0002"
                     /evalue="2.20E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg398_6"
                     /protein_end="194"
                     /protein_start="174"
                     /score="29.3"
                     /tool="antismash"
                     /translation="AYVVYTSGTTGNPKGVVAEHG"
     CDS_motif       complement(6655..6696)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg398_6_0001"
                     /evalue="4.70E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg398_6"
                     /protein_end="112"
                     /protein_start="98"
                     /score="19.6"
                     /tool="antismash"
                     /translation="LAILKAGGVYVPLDS"
     CDS             complement(7266..7898)
                     /locus_tag="ctg398_7"
                     /transl_table=11
                     /translation="MTWLVKVDHITYACAQGMIEKWAWFHIEVEGGTLIKRVDDIDPHN
                     PNSSMKLWCIDYGSFGIALIEGIDRKEKSQVTLFTELHQDHSIQHVAYETKDLEQFQDR
                     LEKYNCNILGQPITKIDPWGMVKQLFCRGYSPTNPAKTTFAEYVERPKASMSDSKVTFS
                     QKAGKGFYNQIEAAIPQEKYQPFTNFAAMPENWEAPKISEPVSAAHI"
     CDS             complement(8608..9576)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088:acyltransferase 3 (Score: 77.6; E-value:
                     1.6e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg398_8"
                     /transl_table=11
                     /translation="MRWTVLAGLRFILAYIVLSYHLTWCVDASNPLAFLGTLGGLTAIL
                     GFLLISGYSIANSINRNPKGFYQRRVLRIYPLYFCAIIYSLVPFLFSGKNIQLGIIKFV
                     QPDSWTVAGNLLFLQGWGIESLTSNPVVWTLGIEIFCYLLAPLFVKADNKVLLSLIGIS
                     SLSFALFPYTHLPHYSVLQYGLGLLLFLWAWLLGFFYFFNQDKAYAKILLVGLGCLLLR
                     LNHVHSISKYAILIYIISCIVLIYAPRISLTGNLAKLFNYLGNISYPLYLFHIPSMIII
                     YSVLNIKNPVALILFPLLVSIFFHHVIEVPLHSKKVLSPVK"
     CDS             complement(9558..9752)
                     /locus_tag="ctg398_9"
                     /transl_table=11
                     /translation="MSPFTRRSKVNFNAGSDTDTLLLQKIQHVLEMLVNSVTERILDKY
                     LPQLKYLINLRKKLCVGQC"
     CDS             complement(9963..10145)
                     /locus_tag="ctg398_10"
                     /transl_table=11
                     /translation="MVTNSLLTLYFNINNAAAQMTPEPFEDFTEKQFRLTLRTNALGYV
                     YLVNPVSKWLYYLQL"
     CDS             10149..10940
                     /locus_tag="ctg398_11"
                     /transl_table=11
                     /translation="MAIPELPAKVLSSWDRSKEVFMENLWHLHSSTQQSWGFFRESVLE
                     AIDSVTQASYSLADLTVSAVDQVTDLVTSKTQKAVETMTTATGDSVKSMTEAYQDVNEA
                     LAQTKNTAVDVMQTALASSVGDWLQAHPVAFRLVQMLSWAANHPIWSLIILLFAIALAL
                     IIIKAIGRLIEFASLSILRVPLKLIQGFLKVSFISFSQIGNLAGKQLFGAKITDNVLSP
                     TTNQTEKPQRLAEISTRLAALQQEQNQLLQEIAVLMTADKR"
     CDS             10991..11062
                     /locus_tag="ctg398_12"
                     /transl_table=11
                     /translation="MKKPTDHTQQEKTEIEQLSQAELV"
ORIGIN
        1 tctagcttca gaaatcacgg aactgttgaa aaaaaataat ttaggtgtaa ctaccccaag
       61 tcgcggagag aatggtaaac caggtactag tagtactcct ggtaccaaaa ttccgaatct
      121 tgaacagcag cagtattttg ctaatgtcac cacgaaagta attctgcctt tatttaagca
      181 acgtcagaaa ccctttgtca tggtatattg gtcgcgtgat ccggatggta cgcaacacaa
      241 ccaaggtgat agtctcaata gtctgactcc agggattaat ggtccgactt ctttagctgc
      301 aagaaaaaat gttgatcaaa acttagctca actgcgatcg gcacttcaag aattaggtct
      361 agcggattct acaaatatat ttattgccgc cgatcacggt ttttcgacca ttagcaaaga
      421 aagcaaaact agttatgctg caaccctagc ttatcccgat gtgccggacg gttttttacc
      481 tccaggattt ttaggtattg atatcgccaa tgaattaaag cagcctctca aagatccaga
      541 taaggaaaat gcgttaatcg atccgaagtt gggtaagttc tcgaaaaatg gtctaattga
      601 tcaaaatact caatctccag agattgtcat tgctgctaac ggcggttctg atttaatcta
      661 tctacctaag gacgctaata aaaaagtact tgcaaataga attgtcggtt ttctgctaaa
      721 gcaggattat atcagcggtt tatttatcga cgatccttta ggtccgattc ccggtacttt
      781 acccatgagt acaattggct taaaaggcgc atctcgtacc cctacgccct caattgtggt
      841 caactttaag tcatttgaca ctggctgcgg taatcctact ctttgtggtg ccgaaatcgg
      901 tgatactggt ctacaacagg gacaaggaat gcacggtagt tttagtcggg ctgataccta
      961 taactttatg gcagcgattg gacctgattt taaagccggt tatgttgacc aagcgccagt
     1021 cggtaatgct gatgtcgctg tcaccttgac taaagtattg aatttaaagg ttacaggtcg
     1081 tggtaagtta gttggtcggg ttttaaatga aaccttagtt aaaggaccaa acgatgtggc
     1141 ttttaaatcc caaacgttgg agtctccaac tgcggctaat ggcttgaaga ccattctcaa
     1201 atatcaaact gtgggtaata caagatgctt tgatgttgcg ggttttcccg gtcggacttt
     1261 gggtttatag tattctgaaa atcttgtatt gtctgaggct cctaataaat tgattgcggg
     1321 ataaaatcaa actaagctgc aaaaaatctt gtgtttaaag atgatgatag ccatccccca
     1381 gcaaccccaa aaaatgacca tcgcagaata ttttgcctgg gaacctcagc aagatgttcg
     1441 ctacgaatat gtcaacggcg aagtttttgc catgacaggc ggtacaattc cccacaatga
     1501 tattgcgctt aatctgtaca ctgctctacg tccccatctc cgcgaccgag gttgcagggt
     1561 aaatgtgtcc gatgtgaaag tgcaagtcag tccccacagt ccttactact atcctgatgt
     1621 tattgtcagt tgcgaccctc aagacctcaa cgctcgcaaa tttatccaat atcccaagct
     1681 gattgtcgag gttctctccc ccggtacaag cgccaaagat agaggtgaaa aattctttga
     1741 ttaccagaca atcccgactt tgcaagagta tatcttgatt gactcggaaa aaatctccgt
     1801 cgagcgttac tctcgcggag agggtagaat gtggctttac tatccctaca tagatggaga
     1861 cataattact ctctcaagca ttgaatttga atgtcctatt gaactgcttt acgaaggtgt
     1921 tgtcttggga actgaggaat aaatgtgttt tcaaagaaaa aattaactca gtaggctgta
     1981 acaatttaag cttaatttaa ataagttagt attgtgaagt cattgctcca caactgtttg
     2041 actcatgaat agccatctac acccaccagg aagcagcggt ttaccaatat taggcgagac
     2101 actatcattt gctttcgacg ataattttat cgaaaagcgc tatcgacaat acggatctat
     2161 ttttaaaacc cacattattg gtagacctac tgtagtgatg gtgggaccag aggcggtgga
     2221 atttgtcctc tccagccata tggataattt ttcttggcgt gagggttggc cggacacttt
     2281 caagatcctg cttggcgaat cactttttct gcaagatgga gaagaacatc gtcaaaagcg
     2341 gcgcttaatg atgccagcat tgcacgggcc agcgctgagt caatatgttg gtaaaatgga
     2401 ggcaattaca cgcgaatacc tgaataagtg gcaggagaaa caggaattta cctggttaga
     2461 ggagttcaag cagctaacat ttgatattgc cagtcaactg ttgctaggta ctaaccccgg
     2521 tgcggaatct gtacgcctta gcaatttgtt tacaacgctg acaaatggtt tgtttgccct
     2581 caatccgttg cgcttaccag tcacaaagtt agggaaagcg aactgacaag tcagcgcttg
     2641 cgctatcgca gcccgcgacc aaatcctaga atatttaact gaagttgtca gacaacgtca
     2701 acaaaacccc accaacgatg ccttaagttt gctaatccaa gctaaagatg aagatggtaa
     2761 cagtctcagt gaaagagaac ttgttttcca atcggtgctg ttactcttcg ccggacatga
     2821 aactactacc tcaatgttaa cttggctgtg cgtcgaacta gcacgtcatc caaaagtgtt
     2881 gcaacgcgcc agagcagaac aactgcaact gcaacaacat ggtgagttaa acttagaaca
     2941 attggggcaa atgccgtatt tagagcaggt attgtgggaa gttgaacgac tgcatcctcc
     3001 cgttggcggt ggatttcgcg gtgttgtgaa agaatttgaa tttaaaggct ttcatgttcc
     3061 tgctggttgg atggcattat attctattat tggaactcac ggtatgacag aaatttaccc
     3121 tgagccagaa cgttttgatc cagaccgctt tcaacacaaa cagcgacctt ttagcttaat
     3181 tggttttggc ggcggaccta gagtttgtat tggcatcgca tttgccaaaa tggaaatgaa
     3241 aatagtcgcc gcgcaattac tacgcggcta tcaatgggaa atattaccca atcaaagctt
     3301 agagcaagtt agaattccga caaatcgtcc taaagacggt ctgcgagtgc gatttcaatc
     3361 tttgacttca cacaagcaca cgatctcgcc gcccgtcagg tgacagattt attcacaagc
     3421 aagacgttta ggcttatagc ctaagggcgt ttcgtgcaga gtgtcaaacc atcagaaatc
     3481 ggtacgaggc taatagttac acgttcgtca tggcgtatct tctgattcaa agcgcgaatc
     3541 gcttgagtat attcatcttg agattgcgga tcagcaacat ttccatacca gagaacatta
     3601 tcaacagcaa tcaaaccgcc tggacgcacc aactgcaatg ctcgctcgta atatccatca
     3661 taattttctt tatcagcatc gataaaaaca aaatcaaatg tttctgcagt ccctgatgct
     3721 aacaactgat ctaaactatc cattgcggga gctaaacgca gatcgatttt atctgctacc
     3781 cctgcttgct gccaatagcg ctgtgcgatc gcagtatatt cctcactcac atccaaggcg
     3841 ataattttgc catgtggcgg aagtgctaaa gccacactca gcgtactgta accagtaaat
     3901 actcccacct ccagcgtttt taccgctccc atcaactgca ctaacaaagc cataaactgc
     3961 ccttgttccg gtgctatctg catcattgcc tgaggatggc tggcggtttc ttgccgcaat
     4021 tgtcgcagca catccggctc gcgcaacgag gcagacaata gataatcgta aagccgattg
     4081 tcaagaccaa gagtcttttt gtgcggtggc ggtgaggtga tgagtgagaa gttagaaatg
     4141 cggttgatta tgcggttaat tatcataatg gtgctactaa ctgctgatgg tgggaagaac
     4201 cgactacttt acaagttagt atgaaaagcg atcgcctttc cactttagca aaccaaaatg
     4261 aaaatcacga agtaggatgc agcagtaatt tcgatttcaa tttttcactt cttcactagc
     4321 tgtaatcgcg cggtcgaggc aatcctgtaa tttttcagct agtacctgta cgtgaggtgc
     4381 gctgagcaaa gaattatgat cgccaggaac caaatggaca tccaaaagag aaccaacaag
     4441 tttattccag cctaaattag gatcataatc gaagccttca cctgcttctc ggacttcgtc
     4501 gtcaaccata aacagggtta gtttaccagg gtaagcttgc atcacatatg ctgcaaaagc
     4561 ctctgcgctt gcctctccca tgcgtaagct gtggagttcg cgaggtaatg tcaaaccaaa
     4621 acgcaaataa tagctggtgg cgatcttctg caacttgtag gtgaacatct cggtctgcca
     4681 tgtggtccat cctttcagtt tctgacgaag ataggtaagt ccgccttgga acagcttact
     4741 gcgatgaagt tgtattcgct gactaaaagg caatcgtcgc tcagcattag gtgcagaggt
     4801 atccatgaca aatagtaaac cgattttctc accttgactt agcaattgct gcgccatctc
     4861 gtaagccacg ataccaccga aagaatgccc tcccagaaaa taaggtcctg taggttggac
     4921 agtttggatc tctttgatgt agtcagatgc tatgtcttca actcgggtta ggggaggctt
     4981 tccatctaat ccttttgctt ggagagcata tacgggaaga tgtggtagat gcaggaaaag
     5041 ctcgcgataa gaaaggatat ttccgccagc agcatggata cagaataaag gaggtttgtc
     5101 accatgaggt cgaattggca ctagtgatga ccaaggcgct tcatcctctg gcaaggctgg
     5161 tatttctatc tggcggatag tgttggcaag agcttctacc gttcctgatt ttaagagggt
     5221 actcagaggc agctttttcc caaatttctg atcgatttga gcaaatagac gtaaggcttg
     5281 cagggagttt ccaccgagat cgaaataatt atcctgcacg ccaatgggtt ggatgccgag
     5341 aactttttcc caaatttttg ccagttgtat ttctaattca tcccgtgggg ctacagaaat
     5401 tgactctggt agccgtctag catcagcgag tgcaggtaat gatccccgat ccagcttgcc
     5461 attcgggttg aggggtaagc tatccatcag gacaaacact ttcgggatca tttccaaggg
     5521 taacttggcg cgtaaataag tccgcagaac gcttgctgtg gttgcggtgg tcgtcacaac
     5581 ataggcgact aactgccgct catctccctc gtcattgtta gccacaacta caacttgttg
     5641 gatttgggga tgttggacta aagcagcttc gatttctcca agttcaatgc ggatgccgcg
     5701 aattttgatt tgaaagtccg cacgaccgat aaattcaata ttgccatcgg gcagatatcg
     5761 cccccaatcc cccgttttgc aaaagcgctc attgtcgatg gtgacaaact tttgcgcggt
     5821 caactctggt tgatgtaagt atccccgtgt gactccagct ccgccaatat aaatctcacc
     5881 tttactaccc acaggtacta attgctgttc gtcatacaaa cgcaaggaaa cattattcaa
     5941 cggcttgcca acaatgcgtt tgtcaaactt agtatccgta ggcactttgt aacttaagca
     6001 taaagttgtg acttcactac atccatagag ggtatagata tcagccccac taaatatggc
     6061 tttcatctcc tcaatcaggt tgggaggaat caaatcaccg ccaataaata ctcttttgag
     6121 gttgtatcta gtaggttcta aatgattctc ttgaataaag ttgacgattt gccgcatcaa
     6181 actcggaaca gtatgaagat tagtcaagtg ctctagttga ctgactacat aagcaatatc
     6241 taagacattg tctctggtaa aaattacagc cctgccacct accattaaag ggcttaacaa
     6301 ttcaaataaa gagatgctaa aagagaaccg agcaatgcaa gggaatgctt cttgatggtc
     6361 aaactgaaac cgctcttgtg tagctaagat atagttcctc agattgccat gttcggcaac
     6421 gactcctttg ggatttcctg tagtccctga tgtatagaca acatacgccg catgatgtgc
     6481 agttacctga tttaccaaat tggtatcttc ctctttggcg aaggattcag aatctaaaca
     6541 aatggtaacc ccagcataag gtggtaagtt ggcgaggatt tgctgctgtg ttaacaggac
     6601 tgctagttgg gattgattga acaagaaggt caagcgctct tgagggtatg tggaatctaa
     6661 agggacgtag actccaccag ccttcaagat agccagaagt cctattgcta actccaaaga
     6721 aggctgaata cacagaccta ctctcacctc aggaccaaca cccacagtac gtaagtaacg
     6781 tgctagctga ttagcacggc tattcagtgc ttgataggtt aagtgattga cgccaaagac
     6841 tactgctact tcttctggag atcgttctac ttgtgcctca aacaactgat gaatacataa
     6901 atcctcggat tcattttggc tgctatagga gtgaaccaag ggtttttctg cttgattcca
     6961 ttcttggaga tgtattttac tgacagtcat attatttacc ccgattcaat tgatcaaaat
     7021 cttttgccgg tcaaaccttg ctgttttgta gcagctttat ctgattactt tctgagtaac
     7081 ttcagcagct tcatcatgct gactgtataa aacagcgtta tttatgtttc agattggaat
     7141 aaaatgtgct ccgaagcaac agatgacaaa tttccggtac gtaggtggaa atgggatgtg
     7201 cctcggatgc tacagatttg aagtgcttcc ctctgtgttc aatttacagc ttgatagttt
     7261 tgcagttata tatgtgctgc ggagacaggt tcgctaattt ttggagcttc ccaattttct
     7321 ggcatggcag caaaattggt aaatggttga tatttctctt gaggaatagc ggcttctatc
     7381 tgattataaa aaccttttcc tgctttctga gagaaggtga ctttactatc tgacatgcta
     7441 gcttttggtc tttctacata ttcagcaaat gtcgtttttg cagggtttgt gggagagtaa
     7501 cctctacaaa ataactgctt aaccatcccc cagggatcta tttttgtaat tggttgtcct
     7561 aaaatattac agttatattt ttcgagtcta tcctgaaact gttctaggtc ttttgtctca
     7621 taagcaacgt gctgaatact atggtcttga tgaagttctg taaacagagt tacttgagat
     7681 ttctcttttc ggtctatgcc ttcaatcaaa gcaattccaa atgaaccata atcgatgcac
     7741 cagagtttca tactgctatt gggattatga ggatcgatat catcgactcg cttgatcagt
     7801 gttccacctt cgacctcaat gtggaaccat gcccattttt cgatcattcc ctgagcacaa
     7861 gcataagtaa tgtgatcgac tttaactaac caggtcattg gatatctcct taaacatgta
     7921 aattaccaaa caataaatca gctatgacaa atagttgcaa acgagattta ggtggttatc
     7981 aactttttgt cagcattcaa aaaccagtct ctactgagag cagcatcagc atctgatgtt
     8041 acccataact agtcgctcat cgcagaaaaa atctagcaag gcttaggggt ctatattaat
     8101 tattggtaat gtctttgttt caaaatgtct ttaagccaat gaattctaaa aaaagtcatt
     8161 agttttctag ctttgcgcga ttagatttac tggaggaact tttgtcttag atacagtagt
     8221 cttactagag cataaatctc tacgacaact gatgtgtaaa tttactgtaa ataaatagct
     8281 tagatattta aagttgctgt aaattttaga aaataaatgc caataaattc agcgttatta
     8341 cgcatccaga accaaaactt tataataata ctgagttact ttcacacatc tagaaccaaa
     8401 gctttataat aatactgagt tactttcaca catgtagaca gtaattctag ggagtatgaa
     8461 aatggaaact agtgtgaatg caaaaactaa cgtaacttgc agaaccgcag tagttacgtt
     8521 agctaaagat tcgttgacaa tcgggactta aagaactgtg tgtactgtca ttaaagcaac
     8581 aggcgattcg gtaaagtcaa tggaaatcta ctttactgga ctcagcactt ttttggaatg
     8641 tagcggtact tcaatgacat ggtgaaaaaa gattgaaact aataagggga ataagattaa
     8701 ggcaacggga tttttaatgt ttaaaactga atagatgata atcatgctgg ggatgtgaaa
     8761 taggtaaagc gggtaagaaa tattgcctaa ataattaaaa agtttagcta aattacctgt
     8821 taggctgatc cgaggtgcat atatcaaaac tatgcagcta attatataga tcagaattgc
     8881 atatttgcta atactatgaa catgattcaa tcttaaaagc agacaaccta agccaaccag
     8941 gagaatcttg gcgtaagctt tatcttgatt aaaaaagtag aaaaaaccta aaagccatgc
     9001 ccaaagaaat agtaataatc ctaagccata ttgaagcaca gagtaatgag gtagatgagt
     9061 gtaaggaaat aacgcgaatg ataaagatga tatcccaatt aaactaagca agactttgtt
     9121 atcagctttg acaaatagag gagctagtag ataacaaaaa atctcaatac ctaaagtcca
     9181 tactactgga tttgaagtta agctttcaat tccccaacct tgtaaaaata agagattccc
     9241 tgcgactgtc catgaatcag gttggacaaa tttgatgatg ccaagctgaa tgtttttacc
     9301 actaaataaa aaaggaacta gtgaataaat aattgcacaa aaatataatg ggtatattct
     9361 caaaactcga cgttggtaaa aacctttggg atttcgattg atagagttag ctatagagta
     9421 gccagaaatt aataaaaatc ccagaattgc tgtcaatcca cctagtgtac cgaggaaggc
     9481 aagaggattg ctagcatcca cacaccacgt caaatgataa gataaaacaa tataagctaa
     9541 aataaaacga agacctgcta gcactgtcca acgcataatt ttttcctcaa gtttatgaga
     9601 tattttaatt gtggtaaata tttatctaga attctctcag taacactatt taccagcatt
     9661 tccaaaacat gctgaatctt ttgtaataac aatgtatccg tatcactacc agcattaaaa
     9721 ttgacctttg agcgcctcgt gaaaggtgac attaaatcat aagataatta attaaatttt
     9781 ttatattcat acaaccagat ttgcctcagc aatttttcgt gtgaaaaaca cttatttaac
     9841 ctgagcataa atccctagga aaaactacag gtaaatttag tgtgaagaaa ttgcttatat
     9901 atgtaaagtt gtcttgaaat ttgagaaaag caattgatta cagtcaagta ttattacgca
     9961 aattaaagtt gtaaataata caaccatttg ctgacgggat tgactagata aacgtagccg
    10021 agagcatttg ttcttaaagt caggcgaaat tgcttttcag taaaatcctc gaaaggttcc
    10081 ggcgtcattt gagcagcagc attgttaata ttaaagtaaa gagtaagtaa agagttggtg
    10141 accatcagat ggcaattcca gaactgccag caaaagttct ttccagttgg gatcggtcaa
    10201 aagaggtttt catggagaat ctttggcatt tgcactcatc aactcagcaa tcttggggat
    10261 ttttcagaga atctgtgctg gaagcaattg atagtgtcac gcaagcaagc tatagcttgg
    10321 ctgatctcac agtcagcgca gttgatcagg tgacagactt agtaacgagc aagactcaaa
    10381 aagctgtgga gacaatgacg acagcgactg gtgattctgt taagtcaatg acagaagcgt
    10441 accaagatgt caacgaagct ttagcccaga caaaaaatac agctgtagac gtgatgcaaa
    10501 ctgcattagc ttcttctgtt ggtgattggt tacaagctca tcctgtggct tttcggctag
    10561 tacaaatgct ttcgtgggcg gcgaatcatc ctatttggag tttgatcatt ctactgtttg
    10621 cgattgcttt agcactaatt atcatcaaag ccatcggtcg tttgattgaa ttcgctagtt
    10681 tatcaatcct tcgagttcca ctcaaattaa ttcaaggttt tttaaaagtt agttttatat
    10741 cctttagcca gattggcaac ttagcaggca aacaactatt tggtgcaaaa ataaccgaca
    10801 atgtcctctc gccaactaca aatcaaacag aaaaaccgca aaggttagca gaaatttcta
    10861 ctagattagc agcgctgcaa caagagcaaa atcaactttt acaagagatc gctgtactca
    10921 tgacagctga taaaaggtaa ggattcaggt aaaaaatgat agagggcggg aaatctgcta
    10981 aagtggacac atgaagaagc ccacagatca tacacagcag gaaaaaaccg aaatagagca
    11041 gttaagccaa gcggaactgg ttg
//
