LOCUS       c00055_3300020..        7634 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300020054.a:Ga0181594_10010579.
ACCESSION   c00055_3300020..
VERSION     c00055_3300020..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 13:17:35
            Original ID  :: 3300020054.a:Ga0181594_10010579
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7634
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7634
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1897:3811](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1898..3811
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     protocluster    1..7634
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3854:7634](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      3855..7634
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     cand_cluster    1..7634
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="neighbouring"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7634
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             158..1864
                     /locus_tag="ctg55_1"
                     /transl_table=11
                     /translation="MSNRTFQTDTPNVGQPSVGHSSPLCLRGQQLTIDEVYSVAVANRS
                     VSITNDPKVLEEMKASQDLVRKAVDSGQRIYGLTTGFGSMADLPVCASDAEASQTNLLE
                     FLAAGTGKPIAEIHVRSAMVLRANMLLRGASGVRMEIVERLVRFLNAGATPVVGELGSI
                     GASGDLIPLGTIARAITGQAASCKVMMNGREYDRDEVLDFLGYKPISLLPKEALAIVNG
                     TSFSAAIALNHLHSVRNYLSISIAAHGLMIRALLGHEDPFAEFVHRCKPHPGQAWSAQI
                     MRRLLALTDGQATELERAHPREHLQDRYSLRCFPQYIGPIVEGILRIEKTLETEMNAIT
                     DNPLIDTEAGEFFQSGNFLGQYVGMAMDELRRHIGLLAKHLDVQIALLVSPEFNHGLPP
                     SLMGHGDSPVNMNLKGLQITGNSIMPMLTHLGNSLVDHFPTHAEQYNQNVNGLSWGSAN
                     LASQSVDLFANYAAVALIFAVQAVDLRAGKARSKCDGVTLLGSELRALYEAVYEIAGKK
                     PGGEEPFISDGSDRSLEQILADLAESIRSEGAIVEAVSEIVDSLIKVELVT"
     CDS             1898..3811
                     /NRPS_PKS="Domain: AMP-binding (11-401). E-value: 1.8e-105.
                     Score: 344.6. Matches aSDomain:
                     nrpspksdomains_ctg55_2_AMP-binding.1"
                     /NRPS_PKS="Domain: ACP (542-602). E-value: 7.4e-16. Score:
                     50.0. Matches aSDomain: nrpspksdomains_ctg55_2_ACP.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     403.8; E-value: 1.4e-122)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_2"
                     /sec_met_domain="AMP-binding (E-value: 1.3e-106, bitscore:
                     344.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.3e-10, bitscore:
                     27.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNISDGLLDNFRIFPDKVALTFEGTETTYSELEALSAHAASILSE
                     HRVKPGDRVALVVGNVPAFPVWYYAALRLGAIAVSVNTRLTGEEAAFILNDCEASVVIV
                     PDGTDDEFTNDFPEIPILTVSDDGKSSDGNPLDSGDRIDLGACHPTGPNDPGTILYTSG
                     TTGFPKGATLSHQNVRSTVHSFNHLCKMTPEDQLLLMVPLFHCYGQNTVLNSGLNVGAT
                     IIMQRVFDLKESLRLIRDHRVTRLFGVPTTFQLMLEACGPEDIDSVEYFFCAAATLPPQ
                     LGLAWEKKFQKPIFEGYGLTETAPFASYNHPLRHVPGSIGVPVDLVEMKVVNSETGETC
                     GPNEPGEIAVRGPNVMLGYWNRPEETAEAVRDGWFYSGDVGRKDENGYYFIVDRIKDMI
                     AVGALKVFPSEVERVLLDEVSVSECAVVGLPDDTLGEEVVAFIVPTAGTEGDEEVIRSY
                     SLEHLAPYKAPTKVIFLDELPRNPAGKVLKKELRAQYGGGAKEAPGKAEKAPSEILTKL
                     QNAHASTRERILMDFLQEEIRTLTASESAPSVETALLETGMDSLMMVTLAKNLQTQLGS
                     HLDLPATLVFDYPRICDLSGYLLAELDLDNKLEQAPSETEASIEEMSEEEAEEALRKEL
                     EG"
     aSDomain        1931..3100
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg55_2_AMP-binding.1"
                     /evalue="1.80E-105"
                     /label="ctg55_2_AMP-binding.1"
                     /locus_tag="ctg55_2"
                     /protein_end="401"
                     /protein_start="11"
                     /score="344.6"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="RIFPDKVALTFEGTETTYSELEALSAHAASILSEHRVKPGDRVAL
                     VVGNVPAFPVWYYAALRLGAIAVSVNTRLTGEEAAFILNDCEASVVIVPDGTDDEFTND
                     FPEIPILTVSDDGKSSDGNPLDSGDRIDLGACHPTGPNDPGTILYTSGTTGFPKGATLS
                     HQNVRSTVHSFNHLCKMTPEDQLLLMVPLFHCYGQNTVLNSGLNVGATIIMQRVFDLKE
                     SLRLIRDHRVTRLFGVPTTFQLMLEACGPEDIDSVEYFFCAAATLPPQLGLAWEKKFQK
                     PIFEGYGLTETAPFASYNHPLRHVPGSIGVPVDLVEMKVVNSETGETCGPNEPGEIAVR
                     GPNVMLGYWNRPEETAEAVRDGWFYSGDVGRKDENGYYFIVDRIKDMIAVG"
     aSModule        1931..3703
                     /complete
                     /domains="nrpspksdomains_ctg55_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg55_2_ACP.1"
                     /locus_tags="ctg55_2"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2369..2422
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_2_0001"
                     /evalue="5.40E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg55_2"
                     /protein_end="175"
                     /protein_start="157"
                     /score="19.1"
                     /tool="antismash"
                     /translation="ILYTSGTTGFPKGATLSHQ"
     CDS_motif       2924..3004
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_2_0002"
                     /evalue="2.20E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg55_2"
                     /protein_end="369"
                     /protein_start="342"
                     /score="32.8"
                     /tool="antismash"
                     /translation="NEPGEIAVRGPNVMLGYWNRPEETAEAV"
     CDS_motif       3215..3250
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_2_0003"
                     /evalue="1.60E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg55_2"
                     /protein_end="451"
                     /protein_start="439"
                     /score="-0.5"
                     /tool="antismash"
                     /translation="AFIVPTAGTEGDE"
     aSDomain        3524..3703
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg55_2_ACP.1"
                     /evalue="7.40E-16"
                     /label="ctg55_2_ACP.1"
                     /locus_tag="ctg55_2"
                     /protein_end="602"
                     /protein_start="542"
                     /score="50.0"
                     /tool="antismash"
                     /translation="SESAPSVETALLETGMDSLMMVTLAKNLQTQLGSHLDLPATLVFD
                     YPRICDLSGYLLAELD"
     CDS             3855..7634
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (29-451). E-value:
                     1.6e-180. Score: 592.3. Matches aSDomain:
                     nrpspksdomains_ctg55_3_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (556-841). E-value: 3.6e-90.
                     Score: 294.0. Matches aSDomain:
                     nrpspksdomains_ctg55_3_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (912-1068). E-value: 1.8e-29.
                     Score: 95.0. Matches aSDomain:
                     nrpspksdomains_ctg55_3_PKS_DH.1"
                     /NRPS_PKS="type: PKS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 267.2; E-value:
                     4.4e-81)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg55_3"
                     /sec_met_domain="PKS_AT (E-value: 2.1e-91, bitscore: 294.0,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 1.8e-196, bitscore:
                     640.7, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPAKEALAKIRELKQKLAEAESGSNEPIAIVSTACRFPKRSNS
                     PEAFWESLIEEEDVTSELPEDRWDLDAYYDEDADEPGKMYARRGTFLEDIDEMDADFFG
                     ISPREATWVDPQQRIFLEVGWEALERAGWTTEETGKNTGVFVGWMHNDYQNEASESLLD
                     LNPYIATGSAGSFLCGRLSYYLGVQGPSLAVDTACSSSLVALHLACQSLRNRECDRALA
                     GGVNVMVSPKTTIMTCKLHALSPSGHSRAFDASADGYLRGEGCGVVALRRLSDAQRDGD
                     EVLAVIRGSAITHNGYSSGLTAPNPESQQRVIREALKRADLSPTDISYLEAHGTGTELG
                     DPIELNAAASVLGEGRDKSDPLLVGSVKTNLGHLEAAAGIAGIIKTVLAIQNDKIPAHL
                     HFETPNPHIAWDRIPVEVVTEATEWPQDKPRIAGVSAFGMSGTNAHIVIESPPEKTFVP
                     ENADEKYEGPLLLTLSGKNEGAVQQLAARYREILSGDVDPADFCWSAASMRRHFESRAA
                     IAAEDRDQLLNSLSALASGTEAPGLFTGSARPNPIIAWQFTGQGSQYEGMGRAIYDNEP
                     VFKKVLDDCSAELAQHREGDLIQVMFEDGEALGDTFWTQPALFAFHLALAELMKSRGCQ
                     PDLVFGHSLGQYAAAVIAGMLDWKDGIRLIHERARLTGSLPAGGAMAAVFSKAEEVDSF
                     VAVHEGLSIAAHNGSHTVISGPGEKVDAAIADFEKEEIRCKRLDTSHAFHSSLLDPILD
                     EFTAVADSITYHAARIPLVCNVSGQSLAPDFTPNGTYWRNQLREAVRFEGSIQHLSEHR
                     CDLIVELGPQAFLTGMAAACWSGAPETLISTIAKEGNDRTLFNEATAKLFQLGASLDFD
                     AILNPDTTRQRVPLPTYPFQRKRHWGPERPGLQRVQRLTQNPILGEKHELAGVTNESRF
                     ESYIDPDKQHWLGDHRVFEDVLFPGAGYVEMAVAATGGGKVLENLSFEMPLMISGPTAM
                     QTVVRGGDQGVIEIYSHEGPGHPWVRNVSATIGTGERKPAGKVSRSEIEANCPETADPA
                     AFYQMFASLGIHYGTEFQTIRSLRHNDSEVLARLELASDHRGYFLPPMLLDGAFQCLAV
                     GLLRDANSSLFLPVGIESYENYSSTAIGTLSGGLWCHGKWHETEGDMRTADLTLFDDAG
                     KVVVRLEKLKVRAVNRTALRQMTGSGSDRLLYDIQWREGELPPLNNRFSQWLVVSETSE
                     WNETICASLTEKGQHAISVVLDEKLELRDKAATVA"
     aSDomain        3942..5207
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg55_3_PKS_KS.1"
                     /evalue="1.60E-180"
                     /label="ctg55_3_PKS_KS.1"
                     /locus_tag="ctg55_3"
                     /protein_end="451"
                     /protein_start="29"
                     /score="592.3"
                     /tool="antismash"
                     /translation="IAIVSTACRFPKRSNSPEAFWESLIEEEDVTSELPEDRWDLDAYY
                     DEDADEPGKMYARRGTFLEDIDEMDADFFGISPREATWVDPQQRIFLEVGWEALERAGW
                     TTEETGKNTGVFVGWMHNDYQNEASESLLDLNPYIATGSAGSFLCGRLSYYLGVQGPSL
                     AVDTACSSSLVALHLACQSLRNRECDRALAGGVNVMVSPKTTIMTCKLHALSPSGHSRA
                     FDASADGYLRGEGCGVVALRRLSDAQRDGDEVLAVIRGSAITHNGYSSGLTAPNPESQQ
                     RVIREALKRADLSPTDISYLEAHGTGTELGDPIELNAAASVLGEGRDKSDPLLVGSVKT
                     NLGHLEAAAGIAGIIKTVLAIQNDKIPAHLHFETPNPHIAWDRIPVEVVTEATEWPQDK
                     PRIAGVSAFGMSGTNAHIVIESPP"
     aSModule        3942..7058
                     /domains="nrpspksdomains_ctg55_3_PKS_KS.1"
                     /domains="nrpspksdomains_ctg55_3_PKS_AT.1"
                     /domains="nrpspksdomains_ctg55_3_PKS_DH.1"
                     /incomplete
                     /locus_tags="ctg55_3"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       4419..4466
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_3_0001"
                     /evalue="6.70E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="ctg55_3"
                     /protein_end="204"
                     /protein_start="188"
                     /score="21.1"
                     /tool="antismash"
                     /translation="GPSLAVDTACSSSLVAL"
     CDS_motif       4608..4646
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_3_0002"
                     /evalue="1.50E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="ctg55_3"
                     /protein_end="264"
                     /protein_start="251"
                     /score="14.7"
                     /tool="antismash"
                     /translation="FDASADGYLRGEGC"
     CDS_motif       4839..4886
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_3_0003"
                     /evalue="1.80E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ctg55_3"
                     /protein_end="344"
                     /protein_start="328"
                     /score="13.5"
                     /tool="antismash"
                     /translation="YLEAHGTGTELGDPIEL"
     CDS_motif       4947..4991
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_3_0004"
                     /evalue="4.70E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="ctg55_3"
                     /protein_end="379"
                     /protein_start="364"
                     /score="12.5"
                     /tool="antismash"
                     /translation="GSVKTNLGHLEAAAGI"
     CDS_motif       5523..5570
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_3_0005"
                     /evalue="3.20E-06"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="ctg55_3"
                     /protein_end="572"
                     /protein_start="556"
                     /score="19.5"
                     /tool="antismash"
                     /translation="FTGQGSQYEGMGRAIYD"
     aSDomain        5523..6377
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg55_3_PKS_AT.1"
                     /evalue="3.60E-90"
                     /label="ctg55_3_PKS_AT.1"
                     /locus_tag="ctg55_3"
                     /protein_end="841"
                     /protein_start="556"
                     /score="294.0"
                     /specificity="Minowa: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="consensus: mal"
                     /tool="antismash"
                     /translation="FTGQGSQYEGMGRAIYDNEPVFKKVLDDCSAELAQHREGDLIQVM
                     FEDGEALGDTFWTQPALFAFHLALAELMKSRGCQPDLVFGHSLGQYAAAVIAGMLDWKD
                     GIRLIHERARLTGSLPAGGAMAAVFSKAEEVDSFVAVHEGLSIAAHNGSHTVISGPGEK
                     VDAAIADFEKEEIRCKRLDTSHAFHSSLLDPILDEFTAVADSITYHAARIPLVCNVSGQ
                     SLAPDFTPNGTYWRNQLREAVRFEGSIQHLSEHRCDLIVELGPQAFLTGMAAACWSGAP
                     ETLIS"
     CDS_motif       5751..5867
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_3_0006"
                     /evalue="2.60E-17"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ctg55_3"
                     /protein_end="671"
                     /protein_start="632"
                     /score="54.9"
                     /tool="antismash"
                     /translation="GCQPDLVFGHSLGQYAAAVIAGMLDWKDGIRLIHERARLT"
     CDS_motif       6222..6257
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_3_0007"
                     /evalue="1.80E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="ctg55_3"
                     /protein_end="801"
                     /protein_start="789"
                     /score="14.9"
                     /tool="antismash"
                     /translation="YWRNQLREAVRFE"
     aSDomain        6591..7058
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg55_3_PKS_DH.1"
                     /evalue="1.80E-29"
                     /label="ctg55_3_PKS_DH.1"
                     /locus_tag="ctg55_3"
                     /protein_end="1068"
                     /protein_start="912"
                     /score="95.0"
                     /tool="antismash"
                     /translation="PILGEKHELAGVTNESRFESYIDPDKQHWLGDHRVFEDVLFPGAG
                     YVEMAVAATGGGKVLENLSFEMPLMISGPTAMQTVVRGGDQGVIEIYSHEGPGHPWVRN
                     VSATIGTGERKPAGKVSRSEIEANCPETADPAAFYQMFASLGIHYGTEFQTIR"
     CDS_motif       6675..6749
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg55_3_0008"
                     /evalue="3.10E-14"
                     /label="PKSI-DH_m2"
                     /locus_tag="ctg55_3"
                     /protein_end="965"
                     /protein_start="940"
                     /score="45.2"
                     /tool="antismash"
                     /translation="WLGDHRVFEDVLFPGAGYVEMAVAAT"
ORIGIN
        1 caaaaccgcg tgcaaatcct ttaattcgag ggaaaaatta ccaatttttc ctattcttca
       61 taaaaattct gaaacacgta aaaacaacgg tgtaattcag attattcccg cgtgacagcc
      121 gaccccagct ttgttaccta cttctccttt ttctcagatg tcgaaccgaa ccttccagac
      181 cgacacccca aatgtcgggc agccaagtgt cgggcattcc agcccgcttt gccttcgcgg
      241 ccagcagctg acgatagatg aggtgtattc ggtcgctgtt gcgaaccgat cggtttcgat
      301 caccaatgat ccgaaagtgc ttgaagaaat gaaggcctct caggatctgg tccgcaaggc
      361 ggttgattca ggccaacgaa tttacggact cacaacagga ttcggcagca tggcggatct
      421 tccggtatgc gcttctgatg cggaagcatc gcagaccaac cttcttgagt ttctcgccgc
      481 aggcaccggc aagccgattg cagaaatcca cgttcgctct gccatggtat tgcgcgcgaa
      541 catgcttctt cgcggagctt ccggcgttcg catggaaatc gtggagcgac tggtccgatt
      601 tctcaacgcc ggagcaacac ccgtcgtagg cgaacttggc tcaatcggag cgagtggcga
      661 tttgattccc ttgggaacaa tcgcccgcgc gatcaccggg caagctgctt cctgcaaggt
      721 gatgatgaat ggtcgagaat atgatcgtga tgaagttctc gatttccttg gctacaaacc
      781 aatttcactt cttcctaaag aagctctcgc aatcgtcaac ggcacttcgt tttccgcagc
      841 aatcgcgctg aatcatcttc actcggtgcg gaactacctc agcatatcca tcgccgctca
      901 cgggctcatg atccgcgccc tgctcggtca cgaagatccg tttgccgagt ttgtgcatcg
      961 ctgcaaaccc catcccggcc aggcctggtc ggcccagatc atgcgccggc ttctcgctct
     1021 gacagatggt caggcgaccg agctggagcg agcacaccca cgtgaacatc ttcaggatcg
     1081 ctattctctc cgttgcttcc cgcaatacat cggaccgatc gtcgagggca ttcttcgcat
     1141 cgagaaaacg ctcgaaacgg aaatgaacgc gatcacagac aatccgctta tcgacaccga
     1201 ggcaggtgag tttttccaga gcggaaattt cctcggacaa tacgtcggca tggcaatgga
     1261 cgagctgcgt cgtcacatcg gtcttcttgc caaacatctc gatgtccaaa tcgccttgct
     1321 cgtctctccc gagttcaatc acggactgcc accctccctg atgggacatg gtgattctcc
     1381 ggtgaacatg aatctcaagg ggctgcaaat cactggaaac tcgatcatgc caatgctgac
     1441 tcacctcggc aattcactag tcgatcattt cccaacacat gcagagcagt ataaccagaa
     1501 tgtgaatggc ctcagctggg gatcagcgaa tctggcttcg cagtcagttg atctttttgc
     1561 caactacgcc gctgtcgctc tcatttttgc cgttcaggca gttgatctcc gggctggcaa
     1621 ggctcgttca aaatgtgatg gggtgactct tctgggctca gaattgcgcg cactttacga
     1681 agctgtgtat gagatcgcgg ggaaaaagcc gggtggagaa gaacctttca tcagcgatgg
     1741 ttcggaccgc tctctggagc agattcttgc tgacctggcc gagtcgattc gaagcgaagg
     1801 agcaattgtc gaagcggtct cggagatcgt tgactctctc atcaaggtcg agttagttac
     1861 ataacccgaa ccacattccg ttcggagcgc cgagacgatg aatatcagcg acggactcct
     1921 cgataatttc cgcatttttc ccgacaaagt cgcgctgact tttgagggga ccgaaacaac
     1981 atattccgag ctggaggctc tttccgccca cgctgcatca attctttcgg agcacagggt
     2041 aaaaccagga gatcgagtcg ctctcgtcgt tgggaacgtg ccagctttcc ccgtatggta
     2101 ctatgcagca ctgcgtctcg gagcaatcgc cgtctccgta aacactcgac tcacgggcga
     2161 ggaggctgcc ttcattctca atgattgcga agcctctgtt gttatcgtcc cagacggaac
     2221 ggatgatgaa ttcacgaatg acttcccgga aatccccatc ctgactgttt ccgacgacgg
     2281 aaaaagttcc gacgggaacc cgctcgattc aggtgatcgc attgatctgg gtgcctgcca
     2341 tccaacagga ccgaacgatc caggaacgat tctctacact tcaggaacca ctggatttcc
     2401 caagggcgct accctttcgc accagaacgt gcggtcgaca gtccactcct tcaatcatct
     2461 ctgcaagatg actccagagg atcaactgct tctcatggtg ccgcttttcc actgctatgg
     2521 gcagaacacg gtgctcaaca gtggtctcaa tgtcggggcg acgatcatca tgcagcgtgt
     2581 cttcgatttg aaagaaagcc tgcgtttgat ccgcgatcat cgagtgacga gactttttgg
     2641 cgtgccgacg actttccaac tgatgctcga agcctgcggt cccgaggata ttgactcggt
     2701 cgaatatttc ttctgcgctg cagcgacttt gccaccgcag ctcggcctcg cctgggagaa
     2761 gaaatttcag aaacccatct tcgaaggata cggccttacg gaaacggctc cgtttgcctc
     2821 ctacaatcat ccgctgcgac acgttccggg atccattggc gtcccggtcg atctcgttga
     2881 gatgaaggta gtcaattctg aaaccggtga aacatgcgga ccaaatgaac cgggtgaaat
     2941 tgccgttcgg ggtcccaatg tcatgctcgg ctattggaac cgccccgagg aaacagcaga
     3001 agccgttcgc gacggttggt tctactcggg agatgtcgga cgaaaagacg aaaacgggta
     3061 ctatttcatc gtcgatcgca tcaaagacat gatcgccgtc ggcgcactaa aggtatttcc
     3121 ctcggaagtg gagcgagttt tgctcgatga agtaagcgta tcggaatgcg ctgtcgtcgg
     3181 cttacccgat gacacccttg gcgaagaagt cgttgccttc attgtcccga ccgcaggaac
     3241 cgaaggcgat gaggaagtga tacgtagcta cagcctcgaa catctcgccc cctacaaagc
     3301 gccgaccaaa gtaatttttc tcgatgagct tccccgaaac ccagccggaa aagttttgaa
     3361 gaaagaactc cgggcgcagt atggtggcgg agcaaaagaa gcgcccggga aagcggagaa
     3421 ggctccgagt gaaatcctga ccaagctgca aaatgctcat gcatcgactc gtgagcgcat
     3481 cctcatggat ttcctccagg aggaaattcg cacgctcact gccagtgaat ctgctccttc
     3541 tgtggagact gcccttctcg aaaccgggat ggattccctg atgatggtga ctcttgcaaa
     3601 aaacctgcaa actcaacttg gatcccatct cgacctaccc gcaacgctcg tgtttgatta
     3661 tccgagaatt tgcgatttgt caggatatct tctcgccgaa ctggatctcg acaacaaact
     3721 tgagcaggcc ccctctgaaa cagaagcttc gatagaggaa atgagcgaag aggaggccga
     3781 ggaagccctc cgaaaagagc ttgagggctg aatcattgag tctctgaaag cgtccactgc
     3841 gtaactgatt ttccatgtct tcccccgcta aagaggcact cgccaaaatt cgtgaactga
     3901 agcaaaagct cgcggaagcc gaaagcggct ccaacgaacc cattgcgatt gtctcgactg
     3961 cttgtcgttt tcccaaacga tcaaacagcc cggaagcttt ctgggaaagt ctgattgaag
     4021 aagaagacgt cacttccgag ttgccggaag accgttggga tctcgacgcc tactacgacg
     4081 aggacgccga tgaaccgggg aaaatgtatg cccggcgagg aaccttcctc gaagacatcg
     4141 acgagatgga tgccgacttt ttcggcatct ctccgcgcga agcaacctgg gtcgatcccc
     4201 aacagcgaat ctttctggaa gtcggctggg aggctctcga gcgagccgga tggaccacgg
     4261 aagaaaccgg aaagaatacc ggcgttttcg ttggctggat gcataacgat taccagaacg
     4321 aggccagcga atcactgctc gatctgaacc cttacatcgc aaccggatct gctggcagct
     4381 tcctctgcgg acgcctttcc tactatcttg gcgtgcaggg cccgagtctc gcggttgata
     4441 cggcatgttc ctcctcgctc gtcgcacttc acctcgcctg tcaaagtctt cggaatcggg
     4501 aatgcgatcg cgcactggca ggcggcgtca atgtaatggt ctctcccaag acgaccatca
     4561 tgacctgcaa gctccacgcg ctttccccga gtgggcattc ccgagcattc gatgcttcag
     4621 ctgacggtta cctgcgaggc gaaggctgcg gtgtcgttgc tcttcgccgc ctctccgatg
     4681 cccaacgcga tggagatgaa gtcctcgctg taatccgtgg atcagcgatc acacacaacg
     4741 gatacagtag cggcctcacg gcaccgaacc ccgaatcgca gcagcgggtc atccgcgaag
     4801 ccctgaagcg agccgacctt tctccgactg acatcagcta cctggaagct cacgggacgg
     4861 gcacggagct cggtgatccg atcgagctga acgcagcggc atccgttctc ggtgagggcc
     4921 gcgataaatc agacccactt cttgttggct ctgttaaaac taacctgggg cacctcgaag
     4981 ccgccgccgg aatcgccgga atcatcaaga ccgtgctggc aattcagaac gacaaaatcc
     5041 cagcacacct tcatttcgaa acgccaaacc ctcatattgc ctgggatcga atccctgtcg
     5101 aagtcgtaac tgaagcgact gagtggccgc aggataaacc gcgcattgcc ggcgtcagcg
     5161 ccttcggaat gagcgggacg aacgcgcaca tcgtgatcga atctccaccg gagaaaacgt
     5221 ttgttccaga aaatgccgac gaaaaatatg aaggcccgct gcttttaacg ttaagcggaa
     5281 aaaatgaagg tgccgtgcag cagcttgcgg cgcgctaccg ggagatcctt tcaggcgacg
     5341 tcgatcccgc agacttctgt tggtcggccg cttcgatgcg ccgccatttt gagagccgcg
     5401 ccgcgattgc agccgaagac cgcgaccaac ttctcaactc tctctccgca ctcgcttccg
     5461 gtacagaggc ccccggactt tttactggat cagcaaggcc gaatccaatt atcgcctggc
     5521 agttcaccgg tcagggttcg cagtatgagg gaatgggtcg cgcgatctac gacaacgagc
     5581 cagtcttcaa aaaagtcctc gatgactgct ccgccgaact tgcccagcat cgtgaaggtg
     5641 atctcatcca ggtgatgttt gaagatggcg aggccctcgg ggataccttc tggactcagc
     5701 ctgctctttt tgcttttcac ctcgctcttg ccgagctgat gaaaagtcgt ggctgtcagc
     5761 ccgatctcgt tttcggacac agtcttggcc aatatgctgc cgccgttatc gcgggaatgc
     5821 ttgattggaa ggacggaatt cgcctcatcc acgagcgcgc tcgcctcacc ggaagtctcc
     5881 cggcaggagg agcgatggct gcagtctttt ccaaagccga agaagtcgat tcattcgtcg
     5941 ctgttcatga aggtttgtct atcgccgccc acaacggatc gcacaccgtt atcagcggac
     6001 cgggagaaaa agtggatgct gccattgcgg attttgagaa agaagaaatc cgatgcaaac
     6061 gcctcgatac ttctcacgcc ttccactcgt ctctgctcga tcctatcctt gacgaattta
     6121 cggccgtcgc tgactcgatc acttaccacg ccgccagaat tcctctcgtt tgcaatgtgt
     6181 cagggcagtc gctcgctccc gactttactc cgaacggaac ctattggcgc aatcaactcc
     6241 gcgaagcggt ccggttcgaa ggaagcattc agcacctttc cgaacaccgt tgcgacctca
     6301 tcgttgaact cgggccgcaa gcctttctta ccggaatggc ggctgcctgc tggagtggtg
     6361 cacccgaaac gctcatttcg accattgcga aggaaggtaa cgacaggact ttgttcaatg
     6421 aggccaccgc gaagttgttt cagctcggag cgagcctcga ctttgatgcc attctcaacc
     6481 ccgatacgac ccgccaacga gttcctcttc ccacctaccc ctttcaacgc aagcgccact
     6541 ggggaccgga acggccgggc ttgcaacgag tccagcgact gacccagaat cccattctcg
     6601 gggagaaaca cgaacttgca ggagtcacga acgagtcacg gtttgagtcc tatatcgatc
     6661 ctgacaagca gcactggctc ggagatcacc gtgttttcga agacgttctc ttcccgggcg
     6721 ctggctatgt agaaatggcc gttgcagcaa caggcggtgg caaggttctg gaaaatctca
     6781 gctttgaaat gccactcatg atttccggcc ctaccgcgat gcagaccgtc gtgcgtggag
     6841 gtgatcaggg ggttatcgaa atttattccc acgaagggcc aggccacccg tgggtgcgca
     6901 atgtttctgc cacgatcggt actggagaaa gaaagccggc tggaaaagtg tctcgttctg
     6961 aaatagaagc caactgcccg gagacagctg accctgctgc attctatcag atgtttgctt
     7021 cgctcgggat tcactacgga accgagttcc aaacgattcg ctccctccgg cataacgact
     7081 cagaagtact cgcccgcctc gagctagcca gcgatcaccg gggctatttc ctgccaccca
     7141 tgctcctcga cggcgcattc caatgtctcg ccgtgggtct gttgcgagat gccaactcct
     7201 cgctcttcct tcccgtcgga atcgagtcct acgaaaacta ttcctctacc gctattggaa
     7261 cactttccgg tggcctctgg tgccacggca aatggcacga aaccgagggc gatatgcgga
     7321 ccgccgatct cactctcttc gatgacgccg ggaaggttgt cgttcgcctc gaaaagctca
     7381 aagtccgcgc agtgaaccgg actgctcttc gtcaaatgac cggctctggc agtgatcgtc
     7441 ttctctacga catccagtgg cgcgagggcg aactcccacc attgaacaat cgcttcagcc
     7501 aatggctggt cgtaagtgaa acctccgagt ggaacgaaac gatttgcgcc tcactgacgg
     7561 aaaaggggca gcatgccatt tctgtagttc ttgatgaaaa gctggaactg cgcgacaagg
     7621 ccgcaaccgt ggct
//
