LOCUS       c00099_3300023..       10424 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300023169.a:Ga0247762_1000538.
ACCESSION   c00099_3300023..
VERSION     c00099_3300023..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 07:50:18
            Original ID  :: 3300023169.a:Ga0247762_1000538
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10424
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..162)
                     /locus_tag="ctg99_1"
                     /transl_table=11
                     /translation="MNGLPTVQFVADSLNLSPTYLSTLLKSLTGQNTQQHIHNKLIEKV
                     KEKLSATEL"
     protocluster    1..10424
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2395:7108](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2396..7108
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..10424
                     /SMILES="C(C)C(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10424
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     CDS             complement(570..818)
                     /locus_tag="ctg99_2"
                     /transl_table=11
                     /translation="MRYRVYVIELSRKVFTENTKFRVANPQFNGLLECLYVGMTSKTPA
                     ERFMQHRTGYVNKKGHKLSANIVQKYGRYLRPACTNI"
     CDS             complement(830..1735)
                     /locus_tag="ctg99_3"
                     /transl_table=11
                     /translation="MIIAALRSGVTAAFPALNYRTDEELRAAIREIRHASDKPFGVNLI
                     VNRSNPKYKSQLKTLLELKVDFIITSLGSPQEVIEQCKPLGIKVFCDVVDLKYAKKVEA
                     MGADALIAVNNRAGGHAGAVSPYELITLLKSNCNLPVISAGGVATGKDLKQVLDWGAAG
                     ASIGTIFIACEESDITPEYKQAMIDYGEKDIVMTTKLSGSPLTVINTPYVQQLGTKANL
                     LELILNNNKTLKKYAKMLMAFRGMKAVEKAAFGATYKTVWCAGPAIEHVKRVQPIADII
                     NTITQQFDEVSNEAPNVLHR"
     CDS             2396..7108
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (10-433). E-value:
                     1.8e-167. Score: 549.2. Matches aSDomain:
                     nrpspksdomains_ctg99_4_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (535-829). E-value: 1.9e-103.
                     Score: 337.6. Matches aSDomain:
                     nrpspksdomains_ctg99_4_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (899-1064). E-value: 4e-23.
                     Score: 74.3. Matches aSDomain:
                     nrpspksdomains_ctg99_4_PKS_DH.1"
                     /NRPS_PKS="Domain: ACP (1227-1295). E-value: 3.4e-15.
                     Score: 47.9. Matches aSDomain:
                     nrpspksdomains_ctg99_4_ACP.1"
                     /NRPS_PKS="Domain: Thioesterase (1332-1547). E-value:
                     2.9e-30. Score: 98.1. Matches aSDomain:
                     nrpspksdomains_ctg99_4_Thioesterase.1"
                     /NRPS_PKS="type: PKS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 206.9; E-value: 1e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg99_4"
                     /sec_met_domain="PP-binding (E-value: 5.4e-13, bitscore:
                     38.5, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 2.9e-168, bitscore:
                     549.2, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3e-104, bitscore: 337.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 5.1e-10, bitscore:
                     29.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPRHSKESIAIVGMSCRFPNVSSLDEFWELLKQGKDTIAEIPA
                     ERWNFQKYYDSDPSVMGKTNQRHASLLSGVHDFDPLFFNISPAEAIEMSPSQKLMLELA
                     WEAIENSTMPFHRIQGQNVGVYVGNIWTDFEHYRKAKNARATLHSAVGMSSNVIANRVS
                     FAFGFTGPSLVIDTGCSASLVALHLACNSLLNNEIDMSVVGGVNHILDPDKYVELTQFG
                     GLSVNGKCSTFDNDADGFVRGEGGGALLLKRLSDAERDQDKILAVVRGTAVNNNGYNDT
                     LPATSIQGQKSLLERVYREAGIAASDVHYIEAHGTGTKLGDPNEAKAIGEFFRTGRNGT
                     PLRVGSVKTNIGHTEATAGIAGLIKVVLAMQHALLPPNLNFKTPNTNIPFADLKLEVQT
                     NVSDWPVKNGETRKAGINSFGWGGTNAHTVLEEYHRKQPVEPSTSADRFCLPLSAKSSQ
                     ALKEMASAFLRQLESVDAEMCRAICLATALRKAEFDHRHLFFGDDHEELLDQLRNFVAD
                     ESEIAPCNPATKEPKIVFVFPGQGGQWLGMGRDLMAKERIFQEAIVECDAVFRKYTTWS
                     LLEQLQATPENSRLTEIDVIQPATCAIQIALAKLWISWGIRPQAVVGHSMGEVAAAYIS
                     GALTLDDAAKVICTRSLLMKTLSGRGGAMAVTELSKAEAEQTAALYPGKLSLAVNNSPK
                     STVLAGDKDSIAEVIADLETKGLFCRLVKVDVASHSPQMDPLKQPLREALQQIKPFPTH
                     IPFVSTVLNKVMNGTDMGTEYWIDNLRGMVQFAAVVERLLHEQHTVFIEVNSHPVLVNA
                     VNECADFHKKKITALASVYRDKRERDEMMKNLAEFYSRGYSVPWHTFFGSSTVSHVPLP
                     SYPFQRERFEIEDLSEEIKISKEISAKFPLLGDKINLADTATTSYWESSISLNKFPYLR
                     DHVIHDAIELPVSCHIEMVFEAISEIFKGTIPVRIEELNFSQYLTLSENMTIDIQIKLT
                     WTEQHTGKVYIFKRENNIWVQLAEGSIVNALAEPASFETVFDNLEYHEPAFTEGETYYD
                     LLHSVGQQYGKHFQQLTGLDRIGSQPFPNVLFSIKPDHYIRLTSDKYEVHPALMSSFFQ
                     PVFAQLAQLEEGNFLDVKFTKIGRLALEGVLNYGRELRGMLVFKNLVRKNGASNSWVFN
                     ADITIANHDNTVVMYIAGLEGYAEKRTPTAVTLQGKKAAADAFGIRTEGITYEERQQAL
                     EQMITHHVANIIKTTPSRIKRTISFKSMGVDSLMAVQLRNHLEKEVSLKIPVGMFWTHP
                     NIGEYAVYLNSLLDAEQHANSAAAEKKNTRENNSWFTVAEPNPDAAMRCFCFHDAGGSA
                     SLFDGWEKYIDKSLIELVVLEMPGRGRRLDETPYEDAPTLIRDIMPELTKWLTKPYIFV
                     GHSMGGLVAFELIRALRKAGTALPEALFISSTSGLNAYQKSQVDYTVSAEELVNQYPHL
                     HIDNIGSLEMQEILVNILRADLKLLHNYQYAVEELLDIPITAIHGNEDERVKRHQIEQW
                     QAETTSSFRLVPRPGGHRYIQYDAEFVVQLIQEEAVAQMSMVNKQTISNP"
     aSDomain        2426..3694
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg99_4_PKS_KS.1"
                     /evalue="1.80E-167"
                     /label="ctg99_4_PKS_KS.1"
                     /locus_tag="ctg99_4"
                     /protein_end="433"
                     /protein_start="10"
                     /score="549.2"
                     /tool="antismash"
                     /translation="IAIVGMSCRFPNVSSLDEFWELLKQGKDTIAEIPAERWNFQKYYD
                     SDPSVMGKTNQRHASLLSGVHDFDPLFFNISPAEAIEMSPSQKLMLELAWEAIENSTMP
                     FHRIQGQNVGVYVGNIWTDFEHYRKAKNARATLHSAVGMSSNVIANRVSFAFGFTGPSL
                     VIDTGCSASLVALHLACNSLLNNEIDMSVVGGVNHILDPDKYVELTQFGGLSVNGKCST
                     FDNDADGFVRGEGGGALLLKRLSDAERDQDKILAVVRGTAVNNNGYNDTLPATSIQGQK
                     SLLERVYREAGIAASDVHYIEAHGTGTKLGDPNEAKAIGEFFRTGRNGTPLRVGSVKTN
                     IGHTEATAGIAGLIKVVLAMQHALLPPNLNFKTPNTNIPFADLKLEVQTNVSDWPVKNG
                     ETRKAGINSFGWGGTNAHTVLEEYH"
     aSModule        2426..7036
                     /complete
                     /domains="nrpspksdomains_ctg99_4_PKS_KS.1"
                     /domains="nrpspksdomains_ctg99_4_PKS_AT.1"
                     /domains="nrpspksdomains_ctg99_4_PKS_DH.1"
                     /domains="nrpspksdomains_ctg99_4_ACP.1"
                     /domains="nrpspksdomains_ctg99_4_Thioesterase.1"
                     /final_module
                     /locus_tags="ctg99_4"
                     /monomer_pairings="mmal -> Me-mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       2903..2950
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0001"
                     /evalue="3.60E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="ctg99_4"
                     /protein_end="185"
                     /protein_start="169"
                     /score="16.0"
                     /tool="antismash"
                     /translation="GPSLVIDTGCSASLVAL"
     CDS_motif       3092..3130
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0002"
                     /evalue="2.20E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="ctg99_4"
                     /protein_end="245"
                     /protein_start="232"
                     /score="14.2"
                     /tool="antismash"
                     /translation="FDNDADGFVRGEGG"
     CDS_motif       3323..3370
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0003"
                     /evalue="2.30E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ctg99_4"
                     /protein_end="325"
                     /protein_start="309"
                     /score="13.2"
                     /tool="antismash"
                     /translation="YIEAHGTGTKLGDPNEA"
     CDS_motif       3428..3472
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0004"
                     /evalue="8.10E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="ctg99_4"
                     /protein_end="359"
                     /protein_start="344"
                     /score="11.9"
                     /tool="antismash"
                     /translation="GSVKTNIGHTEATAGI"
     CDS_motif       3995..4051
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0005"
                     /evalue="1.10E-08"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ctg99_4"
                     /protein_end="552"
                     /protein_start="533"
                     /score="26.9"
                     /tool="antismash"
                     /translation="VFVFPGQGGQWLGMGRDLMA"
     aSDomain        4001..4882
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg99_4_PKS_AT.1"
                     /evalue="1.90E-103"
                     /label="ctg99_4_PKS_AT.1"
                     /locus_tag="ctg99_4"
                     /protein_end="829"
                     /protein_start="535"
                     /score="337.6"
                     /specificity="consensus: mmal"
                     /specificity="Minowa: mmal"
                     /specificity="PKS signature: Methylmalonyl-CoA"
                     /tool="antismash"
                     /translation="VFPGQGGQWLGMGRDLMAKERIFQEAIVECDAVFRKYTTWSLLEQ
                     LQATPENSRLTEIDVIQPATCAIQIALAKLWISWGIRPQAVVGHSMGEVAAAYISGALT
                     LDDAAKVICTRSLLMKTLSGRGGAMAVTELSKAEAEQTAALYPGKLSLAVNNSPKSTVL
                     AGDKDSIAEVIADLETKGLFCRLVKVDVASHSPQMDPLKQPLREALQQIKPFPTHIPFV
                     STVLNKVMNGTDMGTEYWIDNLRGMVQFAAVVERLLHEQHTVFIEVNSHPVLVNAVNEC
                     ADFHKKKITALASV"
     CDS_motif       4166..4231
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0006"
                     /evalue="9.50E-06"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="ctg99_4"
                     /protein_end="612"
                     /protein_start="590"
                     /score="18.5"
                     /tool="antismash"
                     /translation="TEIDVIQPATCAIQIALAKLWIS"
     CDS_motif       4238..4348
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0007"
                     /evalue="8.60E-19"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="ctg99_4"
                     /protein_end="651"
                     /protein_start="614"
                     /score="59.3"
                     /tool="antismash"
                     /translation="GIRPQAVVGHSMGEVAAAYISGALTLDDAAKVICTRSL"
     CDS_motif       4565..4597
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0008"
                     /evalue="5.10E-04"
                     /label="PKSI-AT-mM_m6"
                     /locus_tag="ctg99_4"
                     /protein_end="734"
                     /protein_start="723"
                     /score="12.8"
                     /tool="antismash"
                     /translation="VDVASHSPQMDP"
     CDS_motif       4706..4750
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0009"
                     /evalue="3.90E-03"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="ctg99_4"
                     /protein_end="785"
                     /protein_start="770"
                     /score="10.0"
                     /tool="antismash"
                     /translation="GTEYWIDNLRGMVQFA"
     aSDomain        5093..5587
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg99_4_PKS_DH.1"
                     /evalue="4.00E-23"
                     /label="ctg99_4_PKS_DH.1"
                     /locus_tag="ctg99_4"
                     /protein_end="1064"
                     /protein_start="899"
                     /score="74.3"
                     /tool="antismash"
                     /translation="PLLGDKINLADTATTSYWESSISLNKFPYLRDHVIHDAIELPVSC
                     HIEMVFEAISEIFKGTIPVRIEELNFSQYLTLSENMTIDIQIKLTWTEQHTGKVYIFKR
                     ENNIWVQLAEGSIVNALAEPASFETVFDNLEYHEPAFTEGETYYDLLHSVGQQYGKHFQ
                     QLT"
     CDS_motif       5177..5251
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0010"
                     /evalue="1.60E-05"
                     /label="PKSI-DH_m2"
                     /locus_tag="ctg99_4"
                     /protein_end="952"
                     /protein_start="927"
                     /score="17.5"
                     /tool="antismash"
                     /translation="YLRDHVIHDAIELPVSCHIEMVFEAI"
     aSDomain        6077..6280
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg99_4_ACP.1"
                     /evalue="3.40E-15"
                     /label="ctg99_4_ACP.1"
                     /locus_tag="ctg99_4"
                     /protein_end="1295"
                     /protein_start="1227"
                     /score="47.9"
                     /tool="antismash"
                     /translation="MITHHVANIIKTTPSRIKRTISFKSMGVDSLMAVQLRNHLEKEVS
                     LKIPVGMFWTHPNIGEYAVYLNSL"
     aSDomain        6392..7036
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg99_4_Thioesterase.1"
                     /evalue="2.90E-30"
                     /label="ctg99_4_Thioesterase.1"
                     /locus_tag="ctg99_4"
                     /protein_end="1547"
                     /protein_start="1332"
                     /score="98.1"
                     /tool="antismash"
                     /translation="CFCFHDAGGSASLFDGWEKYIDKSLIELVVLEMPGRGRRLDETPY
                     EDAPTLIRDIMPELTKWLTKPYIFVGHSMGGLVAFELIRALRKAGTALPEALFISSTSG
                     LNAYQKSQVDYTVSAEELVNQYPHLHIDNIGSLEMQEILVNILRADLKLLHNYQYAVEE
                     LLDIPITAIHGNEDERVKRHQIEQWQAETTSSFRLVPRPGGHRYIQYDAEFVV"
     CDS_motif       6587..6649
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg99_4_0011"
                     /evalue="1.30E-07"
                     /label="NRPS-te1"
                     /locus_tag="ctg99_4"
                     /protein_end="1418"
                     /protein_start="1397"
                     /score="24.1"
                     /tool="antismash"
                     /translation="PYIFVGHSMGGLVAFELIRALR"
     CDS             7121..7561
                     /locus_tag="ctg99_5"
                     /transl_table=11
                     /translation="MQELITDKLIGTWKLVSWKYNGENDVPTDFFGENPGGILTYDSSG
                     YMNAQLNKSGRVRFVSESLTEGSSEEISQAYLSYAAYYGKYYEKSPGEIIHIVEGSLFP
                     NWGVGHEEIRYAKIEGEYLVLSTPPIEAKGRKTIFTVTWKRA"
     CDS             complement(7583..8008)
                     /locus_tag="ctg99_6"
                     /transl_table=11
                     /translation="MKKELKRPSGKEVYATLTLEKENGLIFLDWNGFLNLELVKAGSEE
                     LLIWIKQHKVTKVLVDNSKVSGPWQSANGWYETDWNPRAAKEGLAFMAVIMSENVFAQL
                     SVQGFAKVTQGVYTVNIFNGQPQARTWLAQQTAAASK"
     CDS             8394..8618
                     /locus_tag="ctg99_7"
                     /transl_table=11
                     /translation="MSQLQDWACDNHSGYAIKPGEFDQLHNLKVNDKIVIKSHNVSHAP
                     KYAYPIISGDYVEQDSKMIYKRAPRKGGC"
     CDS             8841..10424
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1098:enterobactin/ferric enterobactin esterase (Score:
                     107.2; E-value: 1.7e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg99_8"
                     /transl_table=11
                     /translation="MKVRLLTLFLFCARLVLAQSNTENYPVDPASEEQKGVPKGEILKF
                     TFADSKIFPGTSREISIYIPAQYKADKPACVYVNQDGVQWKAPTVFDNLIAKGEMPVTI
                     GVFVTPGRVLAQSTDALDRFNRSFEYDGLGDRYARFLLEEVFPFVERQKTADGRAIDLS
                     DKGNDRAIGGGSSGAVCAFTAAWERPEEFSRVFSAIGTYTGLRGADRYDILVRKQEPKP
                     IRIFLQDGSGDLNIYAGDWWKANESMERALIFAGYDVKSVWGTGGHNGTHGTAVFPEAM
                     RWLWRDYPKPIKPGVSKNQYLSDILVEGQGWELVGENYNFTEGVAVNAKGEVFFQDIPN
                     GKTYKIGKDGKPELYIADSKKASGTTFSATGEMATITGGWGDPVRQVRRYKNADAFSVA
                     TDEISGNDITMAFNGNIYLTSPDGRENPSKLYLIKPNGERSVVDEGLKFANGLCLSPDQ
                     TQLYVTESATHWVWVYQVQADGTLAHKQKYGWLHVRDTDENAWSDGLKCDRDGRIYVTS
                     LSGIQVMDQLG"
ORIGIN
        1 tagctcggta gcggatagtt tttctttcac tttttcaatt aatttattgt ggatatgctg
       61 ctgggtattt tgccctgtta atgattttag taaagtactc aaataagtag gtgataaatt
      121 caatgaatca gcaacaaatt ggaccgttgg aaggccattc atatttggat tgttaaagtg
      181 ggcattgagt aatctttcaa ggtttttcaa tattttatga ttgcttattt ttcgagttat
      241 aaactgtcgc tgatagaatc tctcggaata attgagcaag gtcgctattt gagaaacaat
      301 aaagatgtaa tgttcactaa aaggactaca aattggcgcc ttaccgtgtc tcaattatca
      361 atttggttcg aaggaggtga tatttaattt tcatctacgg ccacactttc caagtttaac
      421 cgcattggta cgcaagctgg tttagggagc tcagatgtca tattacactg tatgcaagtt
      481 ggtgattttt ttgcactccc gccgtctcag gtcccaggca agtttttctt tcattgccaa
      541 cgcctctgtc cttgtcatag acatcatgtt caaatgttcg tacaagctgg acgcagatac
      601 cgcccgtatt tctgtacaat gttggcggat agcttgtgcc cttttttgtt gacgtatcct
      661 gttcgatgct gcataaatcg ctctgctgga gtcttgctcg tcatgccgac ataaagacat
      721 tccagtaatc cgttgaattg tggattggca acccggaatt ttgtgttttc agtaaagact
      781 tttcgcgaga gctcaattac gtaaacccta tacctcatag atattggcgt tagcgatgca
      841 gcacgttagg tgcctcattc gaaacttcat caaattgttg tgtgatcgta tttataatgt
      901 cagctatcgg ctgtacacgc tttacgtgtt caatggcagg gccggcgcac cacactgttt
      961 tataggtagc tccgaacgca gctttttcaa ccgctttcat cccacggaaa gccatgagca
     1021 ttttagcata cttctttaag gtcttgttgt tattgaggat caactccaaa agattagctt
     1081 ttgtaccgag ctgttgaaca tagggtgtgt taatgactgt gagcggtgag ccagagagct
     1141 tcgttgtcat gacaatatct ttttcgccat aatcgatcat cgcctgtttg tattcgggtg
     1201 tgatatccga ttcttcgcaa gcgataaaaa tagttcctat cgatgctccc gctgcacccc
     1261 aatcgagcac ttgtttcaga tctttccctg tcgcaacacc accagcagaa attactggaa
     1321 ggttgcagtt gctctttaac agtgttatga gctcataagg cgaaactgct cctgcatgtc
     1381 ctccagccct gttgtttacc gcaatcaagg cgtctgcacc catcgcctcc acttttttcg
     1441 catattttaa gtcaacaaca tcacaaaaga cttttattcc taacggcttg cattgctcaa
     1501 ttacttcctg ggggctaccc agggaagtaa taatgaaatc aacttttaac tccagcaacg
     1561 ttttgagttg tgatttgtac ttaggattgg agcggtttac aatgagattt acaccaaatg
     1621 gtttatctga tgcgtgcctt atctcacgaa tggcggctct aagctcctca tccgttctat
     1681 aattaagcgc cggaaatgct gcagttacgc cactacgcaa tgcagcaata atcattcggc
     1741 tgttagaaat gaggaacatc ggtgctaaaa tgatgggata ccggattccg agcagcttgt
     1801 caagagttgt cattatcaaa tataacaaag ccacgctatg ttagcgagcg ctgactgtca
     1861 agattgagac tttgtatccg ggagtaacga acctaacatc tccaacggga tcaccttatc
     1921 atggtgtgtc atggccagat cctgggcacg cactgcggct ctggaaagcc cggtatgccc
     1981 ggtgtaatgg atagaaattt catggaaacg tgaatgtccg gcacaatcca gccaatttgg
     2041 gcaaattcga gttggtcaag ggtgtattat gtatagaatt aagttgatat agtgtttgga
     2101 tgtaatattt tccactatta ttccattttt tcttgatttt gttaatttgg tgattgttca
     2161 tgtaacgttt aagtaatata tatccgacat ataatatatt ggatatatat atatcagggt
     2221 gatgtatttt gaatacgtta aagcgttttg agaaaaagct tctctttttt ctgcaatcga
     2281 ttttgggttg gtctgtttta tatttaagtt ttcgtaagct tttgtattta attgaatctt
     2341 tttaatgaaa aagggtgggt agattcgcta catcatcctg aattgttgtc tgcctatgaa
     2401 ccaacctcgt cactccaaag aatctattgc tattgtaggt atgtcttgcc gcttccccaa
     2461 tgtctcttcc ctcgatgaat tctgggaatt gctgaagcaa gggaaagaca cgattgccga
     2521 aattccagct gagcgttgga actttcagaa gtattatgac tctgaccctt ctgttatggg
     2581 taaaaccaat cagcgtcatg cctctctact gagtggggta cacgatttcg atccgttgtt
     2641 tttcaatatt tcccctgctg aagcgatcga aatgagccct tcgcagaaat tgatgctgga
     2701 gctggcctgg gaagcgattg aaaactcgac catgcccttc catcgtatac agggacaaaa
     2761 tgtgggtgtg tatgtgggga atatctggac tgattttgag cattatcgca aagcgaaaaa
     2821 cgcccgcgct accctgcatt cggccgtggg catgtcttcc aatgtcattg ccaaccgggt
     2881 gtctttcgcc ttcggattca ctggccccag cctggtgatc gatacgggct gctcggcgtc
     2941 gctcgttgcg ctgcacctgg cctgtaatag tctcttgaat aacgagatcg atatgtcagt
     3001 ggtcggcggg gtaaatcaca ttctcgatcc cgataaatat gtcgagctta cacaattcgg
     3061 tggtctgtca gtcaatggaa aatgcagcac gttcgataac gatgccgatg gtttcgtacg
     3121 tggcgaaggt ggtggcgcgt tattattaaa aagactgtcc gatgcggagc gtgatcagga
     3181 taaaatcctc gccgtagtcc gggggacggc tgtcaataat aatggataca acgatacgct
     3241 gccggctacg agcattcagg gccaaaagtc actgctcgaa agagtatacc gggaagccgg
     3301 cattgccgcg agcgatgttc actatataga ggctcacgga acgggcacca agctgggtga
     3361 ccccaatgaa gccaaggcta tcggcgaatt ctttagaaca ggccgcaacg gcacgcccct
     3421 gcgcgtgggt tctgtaaaga ccaacatcgg tcataccgaa gccacagccg gcattgccgg
     3481 tcttatcaag gtggttctcg ccatgcagca tgccctcctt ccacccaacc taaacttcaa
     3541 aaccccaaac accaatattc cctttgccga tctcaaactc gaggttcaga ctaatgtgag
     3601 cgactggccg gttaaaaatg gagaaacacg caaagcgggt ataaattctt ttggatgggg
     3661 tggtacaaac gcccacaccg tactggaaga ataccaccgg aaacaaccgg tagagccctc
     3721 cacatcagcc gatcgttttt gtttgcccct gtcggcaaaa tcatcgcagg ccttgaaaga
     3781 aatggcaagt gcctttctcc gccagttgga aagcgtcgac gctgaaatgt gccgtgcaat
     3841 ctgcttggcc acggcactgc gtaaagctga attcgaccat aggcatcttt tcttcggaga
     3901 cgatcacgag gagttgttgg atcagctcag gaacttcgta gcggacgagt ccgagatagc
     3961 gccgtgcaac ccggctacaa aagagcctaa aatagttttt gtttttccag ggcagggtgg
     4021 tcaatggctc ggcatgggcc gcgatctgat ggcgaaagaa agaatattcc aggaagccat
     4081 cgtagaatgc gacgcagtgt tccgtaaata caccacttgg tctttgctgg aacagcttca
     4141 ggctacgccc gaaaacagca ggctgacgga gatcgacgtg atacagccgg ccacctgtgc
     4201 gatacagatc gccctggcca aactttggat ctcctggggc attagaccgc aggccgtcgt
     4261 gggccacagt atgggcgagg tagcggcggc atacatctct ggagcgctga cactggatga
     4321 cgcggccaaa gtaatctgta cgcgtagctt gctcatgaaa acactaagcg gcagaggcgg
     4381 cgccatggcc gtaacagagc tgagcaaggc ggaagcagag caaacagcag ccttatatcc
     4441 gggtaaactt tcgcttgccg tgaacaacag tccgaagtca acggtcttgg ctggcgacaa
     4501 ggattccatc gcggaggtca ttgctgatct ggaaaccaaa ggactattct gccggcttgt
     4561 taaggtagac gttgcttctc atagtccgca aatggacccg ttgaaacaac cgctacggga
     4621 ggcccttcaa caaataaagc ctttcccgac ccatattcct ttcgtttcca cggtcttgaa
     4681 caaagtgatg aatggaacgg atatgggcac agagtattgg atagataacc tgcgcggcat
     4741 ggtacagttt gcagcggttg tcgagagatt actgcacgag cagcatactg tattcattga
     4801 ggtcaactct catccggtat tggtcaacgc tgtcaatgaa tgtgcggact ttcataagaa
     4861 aaagatcacc gcgctggcgt cggtctatcg cgacaagcgc gagcgggatg agatgatgaa
     4921 aaatctcgcg gagttctatt cacgaggata ttccgtgcca tggcatacat tcttcggatc
     4981 gtccaccgta tcgcatgttc cactgccgtc ctatccgttt cagcgcgagc gatttgagat
     5041 tgaagacctg tcggaggaaa taaagatttc gaaggaaata tcagcgaagt ttccgctgct
     5101 tggtgataag atcaacctgg ccgatacggc gactacatcg tactgggaat cttcgatcag
     5161 cctcaataaa tttccgtatt tgcgtgatca cgtcattcac gatgctatcg agctacctgt
     5221 ctcttgccat atcgagatgg tgtttgaggc gatttccgag atctttaagg ggacgatacc
     5281 tgttcgtatc gaagaattga acttcagcca gtaccttacc ctgtcggaaa acatgacgat
     5341 cgacatccag ataaaattaa catggacaga acagcatacc ggtaaggtct atattttcaa
     5401 gcgtgaaaac aatatatggg tgcagcttgc ggaagggagc atcgttaacg ccttggccga
     5461 acccgcgtca tttgaaactg tatttgataa cctggagtac cacgagccgg catttacgga
     5521 aggagaaacc tactacgacc tccttcattc cgtaggccag cagtatggaa aacattttca
     5581 acaactcacg ggcttggaca ggatcggatc acagccgttt cccaatgtat tgttttccat
     5641 taaaccagat cactatatcc gactcacttc cgataaatac gaggttcatc cggccctcat
     5701 gagtagtttt tttcagcctg tatttgcgca acttgctcaa ctggaagaag gaaattttct
     5761 cgacgtcaaa ttcacaaaaa tagggcgcct tgccctggag ggtgttttaa attatggaag
     5821 ggaattgcgg ggtatgttag tttttaaaaa cctggtcaga aagaatggtg cgagtaactc
     5881 gtgggtgttc aatgcagaca ttaccattgc taaccacgac aatacggtgg tgatgtacat
     5941 agcaggcctg gagggctatg cggaaaaacg cacgcctacg gccgtaacgc tccaaggtaa
     6001 aaaagcagca gcggatgcgt tcggtatccg tactgaaggc ataacctacg aagaaaggca
     6061 gcaggcgctc gagcagatga tcacccatca cgtggcaaat attatcaaaa ctacaccgtc
     6121 gcgcatcaag cgtactatct cgtttaagag catgggcgtt gattcgctca tggccgtgca
     6181 gctgcgcaac cacctggaga aagaagtatc gttgaaaata cccgtgggta tgttctggac
     6241 gcatcccaat atcggggaat atgccgtata cctgaatagc ctgctcgatg cagaacagca
     6301 tgccaacagc gcagctgcag agaaaaagaa tacccgcgag aacaactcat ggttcaccgt
     6361 ggccgaacct aatcctgacg cagccatgcg gtgtttttgt tttcatgatg ccggaggaag
     6421 cgcatcgctg tttgatggat gggaaaagta tattgataag tcgcttatcg aactggtggt
     6481 cctggaaatg ccgggacgcg gccgaagact ggatgagacg ccttacgaag atgcgccgac
     6541 gctgatacgc gatatcatgc ccgaacttac caagtggctt accaagccct atatttttgt
     6601 gggacatagc atggggggac ttgtagcatt tgagctcatt cgcgctttgc gaaaagcagg
     6661 gactgcatta cccgaagcgt tgttcatttc ttccacgtcc ggattgaatg cgtatcagaa
     6721 aagccaggta gattacacgg tatcggcaga agagcttgtc aatcaatatc cccacttgca
     6781 catcgataat atcggtagcc tcgaaatgca ggagattctt gtcaacatcc ttcgggcaga
     6841 tctcaagctc ctgcataatt atcagtatgc agtagaagaa ttgctcgata tcccgatcac
     6901 cgccatccat ggcaacgaag acgagcgggt taaacgacac cagatcgaac agtggcaagc
     6961 agaaacaacg tcttcgttcc gccttgttcc ccgtccgggt ggtcaccgct atattcagta
     7021 cgatgccgaa ttcgtcgtgc agctcattca agaagaggcc gtggcccaga tgtcgatggt
     7081 caataagcaa acgatctcca acccataata atacgctctt atgcaggaac tgataacgga
     7141 taaactcatc ggtacgtgga aacttgtatc ctggaagtac aatggcgaaa acgacgtacc
     7201 gacggatttc ttcggagaga atcccggagg catccttaca tacgatagca gcggctatat
     7261 gaacgcccaa ctcaataaat caggtcgcgt ccgttttgtg tcggaatcat tgaccgaagg
     7321 cagtagcgaa gagatcagcc aggcctattt gtcgtatgcc gcttactatg gaaaatacta
     7381 tgagaaatct cctggcgaga tcattcacat tgttgaaggg agtttgtttc ccaactgggg
     7441 agtggggcat gaggagattc ggtacgcaaa aattgaaggg gagtacctag ttctaagtac
     7501 tccccccatt gaggcaaaag gcagaaaaac catttttaca gttacctgga aaagagctta
     7561 acgcgagtaa cgggttgatc aattatttag aggcagcagc agtttgttgc gcaagccagg
     7621 ttctggcttg cggctggccg ttgaatatgt ttaccgtgta gacgccttgg gtaaccttcg
     7681 cgaacccttg aacggatagt tgggcaaaaa cattttccga cattatcact gccatgaagg
     7741 ccaatccttc tttagcggca cggggattcc aatccgtttc ataccagcca ttggctgact
     7801 gccatggacc cgatacctta ctgttatcga ccaatacctt ggtaaccttg tgctgcttga
     7861 tccagatcaa cagttcttcg gagccagctt tcacaagttc aaggttaagg aacccgttcc
     7921 agtcaagaaa aatgaggcca ttttcttttt ccaaagtcag ggtggcatac acttcttttc
     7981 ccgagggccg cttcagttct tttttcatcg tagtgataga tttaaagatt taagattaaa
     8041 aatagcacga tttgcttttc aattttatag cggaaatccg aaaaatatta cgttagttat
     8101 atgatttaaa aacgttgcat tcgtttggat atataagtgc tgtggataaa aatataatcc
     8161 attttatata aatatattat agtatatact tcggaataat tcttatattg ctgatattct
     8221 atgtacatcg atatataata ggattgatcg atgtgttacg taaccacaga tgtgatagga
     8281 tatttcgacg atatatttat tcccctcttt ccttgccagg gaacgcggat ttaaattatt
     8341 ggtagtattt gtcaagtgga aaaattggga atatctcatt tcggggacat ctgatgagcc
     8401 agctgcaaga ttgggcatgc gataatcatt caggttatgc gataaaacct ggcgaatttg
     8461 atcaattaca taacctgaaa gttaacgaca aaatagttat aaaaagccat aacgtatcgc
     8521 acgctcccaa gtatgcatat ccaataatat cgggcgatta cgtagaacag gatagtaaaa
     8581 tgatttataa acgtgcccct cgcaaaggcg gttgttaagg caattatgaa atagagatcg
     8641 ctttatgtgg tctctaaacg tctgtattca tcggtggtaa ctctgtattg tttttaaaag
     8701 ctctcgtaaa gtgctgtggg atacttgaat ccaggctcgt atacgattta accatcaagg
     8761 ccggcttttt cttttgatta ttttctgagc atcgcgtttt attttatgta actttctttc
     8821 taacgtttga aagtctcatc atgaaagtac gtttgctcac gctgtttctt ttctgtgcac
     8881 ggctggtgct ggcgcagtcc aatacagaaa actaccctgt cgatcctgct tcggaagaac
     8941 agaagggcgt tccgaaaggg gagatcctga aatttacttt tgcagactct aagatattcc
     9001 cgggcacctc gcgcgagatc agcatatata tccctgcgca gtataaggcc gacaagccgg
     9061 cgtgcgtgta tgtcaaccag gatggcgtgc agtggaaggc acctacggtt tttgacaacc
     9121 tgatcgcgaa aggcgaaatg cccgtgacca tcggcgtttt tgttacaccc gggagagtat
     9181 tggcccaaag caccgacgca ctggaccggt tcaaccgcag cttcgagtat gacggattgg
     9241 gagaccgcta tgcacggttc ctgctggaag aagttttccc ttttgtcgag cgccagaaga
     9301 cagcggacgg cagagccatc gatctttccg ataaaggaaa cgaccgggcc atcggagggg
     9361 gaagcagcgg cgcggtctgc gcgtttacgg cagcgtggga aagaccggaa gagttctcgc
     9421 gggtgttcag tgccatcggt acgtataccg gtttgcgggg agccgaccgg tatgacatcc
     9481 tggtcagaaa acaggaaccc aaaccgatcc gcatcttcct gcaggacggc tctggtgatc
     9541 tgaacatcta tgccggcgat tggtggaagg ccaacgagtc gatggagcgc gcgctgatct
     9601 ttgcaggcta tgatgtaaaa tctgtatggg gaacgggagg acacaatggc acacatggca
     9661 ctgccgtttt ccccgaggct atgcgctggc tgtggcggga ttatccgaag cccatcaagc
     9721 ccggcgtcag taagaatcaa tacctcagcg atatcctggt ggaaggccag ggctgggagc
     9781 tggtgggaga gaattacaac tttaccgaag gggtagccgt gaatgcaaaa ggagaggtgt
     9841 tctttcagga tatcccaaat ggcaagacct acaagatcgg caaagacgga aaacccgagc
     9901 tctacattgc cgactcgaag aaagcgagcg gcacgacctt ttcggctacc ggcgagatgg
     9961 ccaccattac cggcggatgg ggcgacccgg tgcgacaggt acgccggtat aagaatgccg
    10021 atgcattttc ggtcgctacc gacgaaatct ccggaaatga tattacgatg gcattcaatg
    10081 gaaatatata cctcacctcg cccgacggcc gggagaaccc cagcaaattg tatctgatca
    10141 agcccaacgg cgaaaggagc gtggtggatg aaggactgaa gttcgccaat ggtctatgct
    10201 tgtcgccgga ccaaacacag ctctatgtca ctgagtctgc gacacactgg gtgtgggttt
    10261 accaggtgca ggcagacggc acactggcac ataagcaaaa gtacggctgg ctgcacgtgc
    10321 gtgataccga tgaaaatgca tggagtgacg gactgaagtg cgacagagac ggccggatat
    10381 acgtgaccag cctcagcggc atccaggtca tggatcagct cgga
//
