LOCUS       c00018_3300025..       13420 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300025298.a:Ga0209050_1000013.
ACCESSION   c00018_3300025..
VERSION     c00018_3300025..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 09:55:52
            Original ID  :: 3300025298.a:Ga0209050_1000013
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 729036
            Orig. end    :: 742456
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13420
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[734036:737456](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8420
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    1..13420
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13420
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="2"
                     /rules="AfsA"
                     /tool="antismash"
     CDS             1337..1948
                     /locus_tag="ctg18_612"
                     /transl_table=11
                     /translation="MHANSTQPVLAVFDFDGTLTDRHTFWRYMRFIVGTRSFWLRIIPL
                     LPKMLSVIVGITPLMQARLAFIACYLGGLSVEQEREHAKYFISEQLPLWLRPEALRRLK
                     WHQSMGHVTALVSNSPENYLIPWGQAAGFDYVCGTRLATAKNKLTGGISGTNCVEREKV
                     TRLKGCLSNLDDFYIYAYGDSSGDDALLSIANSPFYRNWY"
     CDS             1952..3715
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 343.9; E-value:
                     3e-104)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_613"
                     /transl_table=11
                     /translation="MNTLSTLAPKHFKRPGSAPTVMIVGAGPIGLTLAILLKKWGVSFR
                     IIEKNAGPSTATKAMAIHSRTLEIFRDLGVAEQAISAGFTINQFSVQSNAKRVLNYNFS
                     YLDATYPLLLSLPQPQTEKILLERLKELGAEVEWNTELVDIENLPGSVRMTLKHADGTD
                     ENFTSRWVAACDGARSNIRKRLDMTFEGSSYDRFFMLADADIQWSGSKDEGAFFLGAQD
                     GYVAVAPISAQSRYRLFIEMPYNLPPEGERPSLSLENFQRLCEGRGQKMTLSNISSTTI
                     ASFQHRRVQSMQQGSVFLLGDSAHIGSPIGGQWMNLGISEAYNLAWKMAYVDQDLADPS
                     LLDSYNDERYPVALEVENTAHRLTGLITVRRRALVWLRDNVLPLLSNRNKVQRKLPAMI
                     SGHQYHYDKSDYIQESVTKKQRRNWNKKGKKPEFQSAPPRAGQLAPDVELWQLQGMPAK
                     RLIDLFHGTFTLLIFSAADQFSPLLPGYYALAESVEKDYPGIKAYCVIDALSSAGLPAW
                     HSTLLDPDWRLHKRYHAKEGMLMLIRPDGYIAFLGADAMTLVTYLNVRSGLLKGARKTI
                     SCETDAVELQL"
     CDS             3835..4926
                     /NRPS_PKS="Domain: ACP (118-188). E-value: 1.2e-13. Score:
                     42.9. Matches aSDomain: nrpspksdomains_ctg18_614_ACP.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1047:phosphopantetheine-binding domain-containing
                     protein (Score: 5.6; E-value: 0.33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_614"
                     /sec_met_domain="PP-binding (E-value: 8.9e-12, bitscore:
                     40.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLQLNDVVQEFIVSNGRIAHSYFSLSEKIIDSLCESNIAKESIL
                     LRLLEQAETVTAHYFNAHQQVLEGVYANGIEAPVSKSIAALEPVHSNPTILAPTPVVEA
                     EAEAVEQAAALSYGQWLRAEISSVTGFQAQQIDFDQSFESLGIDSLGLVDIFESLAQHF
                     PEKKDLTSQLFDAPTPTALLARLEADPQAPAVDVQAWVVDQLATITGFTAEQIDPTQSY
                     ESLGLDSLVQLDFLEAAVAMWPQLKAHSSELANAKFPQATIALIQAALADPQPQAAPSP
                     AATDTQGQEENLLLNALSPLIPETAQSIDLQTPFAQLGLNGFAREALCQSMAQQCSASE
                     FAGEALMSRRTPEDALSLLTRLS"
     aSDomain        4189..4398
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg18_614_ACP.1"
                     /evalue="1.20E-13"
                     /label="ctg18_614_ACP.1"
                     /locus_tag="ctg18_614"
                     /protein_end="188"
                     /protein_start="118"
                     /score="42.9"
                     /tool="antismash"
                     /translation="QWLRAEISSVTGFQAQQIDFDQSFESLGIDSLGLVDIFESLAQHF
                     PEKKDLTSQLFDAPTPTALLARLEAD"
     aSModule        4189..4398
                     /domains="nrpspksdomains_ctg18_614_ACP.1"
                     /incomplete
                     /locus_tags="ctg18_614"
                     /tool="antismash"
                     /type="unknown"
     CDS             5001..8420
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (151-419). E-value:
                     1.1e-72. Score: 237.0. Matches aSDomain:
                     nrpspksdomains_ctg18_615_PKS_KS.1"
                     /NRPS_PKS="type: PKS/NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 177; E-value:
                     1e-53)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_615"
                     /sec_met_domain="PKS_KS (E-value: 1.4e-71, bitscore: 237.0,
                     seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="AfsA (E-value: 1e-11, bitscore: 40.1,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGAVTTTGDFCFSAMAGEFPGAPSTDALWQLLSQGQIAPIESMP
                     TRWELDKASIYSTKAGEKDRIYLDSAFCLIDDVSTPSRHEGRQVAIGKKVLQALLGQLA
                     GQGSELNKARTALVIATSWSDESYFATGMSGKTATPPGFTPGEQVAELAASFALGGPAL
                     SVDTACSSFPYALDMAQALVNSGQADNAIVMALNTVLPPALFLGFSQLTAFSARARMEA
                     FGQDADGIVPGECAVAFLVEPLAQALTAQRRPLGVLRALGMSADGAEGSVFAPGKQAQY
                     SAYQRAYRGLDPRDVDYIETHGTGTPLGDATELASLNSFFAPHRPDGKKITIGSIKSVI
                     GHPLAAAGGASLAKALMILRHKGIPPQPGYRPSTKVDETCLRLATQQVQPLEECQSAIR
                     IGISSFGFGGANAHLVVDEYIPDDQPVAPQPASASACGVVTLDLAIVEAEAALGSHRSL
                     QSFQQQLDQPAAPSVTFPYGRFVDYTPAPGQPLLGQFLAQDHVIDIDGFGMGPKPLAHV
                     DPFKLLITDRVNHLLRRLPGVAGSPGTAMVMCCNMGGERFSNAYSSAHNFYAQAQGAAP
                     GVEVTDVATMLPNMLSGYPAQIFDFKGFHQTLVGTTGLFWQTLLASPQWFNDGITTLLL
                     GAGRFVSAEVEVERARCSTTTEGEGLGLVALRRYQPDAADKPLLVIHAAVLAHAADSLE
                     EACRRLGKEPSDYSNVEVCELQPVAAPASGSLRELTGFLAEASGIETLLAVMLRGARHT
                     VIEVRDAGKTVMWLFTEKLRQWNPTAAEASSPIKHPFMLRFAHSSSHELQQVITPVSLV
                     REPQNDGVDVQQLSDMLTSTLLSGLRVRVRAMESLFALHRGDATQRPAHWQRSAEHIVI
                     ANAQRNPQSLHAQLVVNEAHPYFFDHPLDHIPGILLLEGVLQLIELAMPPLSGRVAYIK
                     SLTIKFQQYVQKQGVIDLHVEQGQDPQMFNAKVMQGGKVMCTCVLGMAYSSAFETSPAG
                     EFTATPCRDKALLHKAREENVIVSDMSGVAQGLSVDTVKLPPEHFFQAGDPAHYSMVYF
                     LEVARQCYMQIAHSHLRIPLNTPMNLLALSFTLDRPIPRNSPLSLAPQAGFDASLQAFK
                     TNRIYIDLFNRGEKIGQANITAQVLSQSAPAA"
     aSDomain        5454..6257
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg18_615_PKS_KS.1"
                     /evalue="1.10E-72"
                     /label="ctg18_615_PKS_KS.1"
                     /locus_tag="ctg18_615"
                     /protein_end="419"
                     /protein_start="151"
                     /score="237.0"
                     /tool="antismash"
                     /translation="LAASFALGGPALSVDTACSSFPYALDMAQALVNSGQADNAIVMAL
                     NTVLPPALFLGFSQLTAFSARARMEAFGQDADGIVPGECAVAFLVEPLAQALTAQRRPL
                     GVLRALGMSADGAEGSVFAPGKQAQYSAYQRAYRGLDPRDVDYIETHGTGTPLGDATEL
                     ASLNSFFAPHRPDGKKITIGSIKSVIGHPLAAAGGASLAKALMILRHKGIPPQPGYRPS
                     TKVDETCLRLATQQVQPLEECQSAIRIGISSFGFGGANAHLVVDEYI"
     aSModule        5454..6257
                     /domains="nrpspksdomains_ctg18_615_PKS_KS.1"
                     /incomplete
                     /locus_tags="ctg18_615"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       5478..5513
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg18_615_0001"
                     /evalue="5.30E-04"
                     /label="PKSI-KS_m3"
                     /locus_tag="ctg18_615"
                     /protein_end="171"
                     /protein_start="159"
                     /score="12.6"
                     /tool="antismash"
                     /translation="GPALSVDTACSSF"
     CDS_motif       5892..5939
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg18_615_0002"
                     /evalue="8.90E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="ctg18_615"
                     /protein_end="313"
                     /protein_start="297"
                     /score="11.7"
                     /tool="antismash"
                     /translation="YIETHGTGTPLGDATEL"
     CDS             8428..8943
                     /NRPS_PKS="Domain: Polyketide_cyc2 (18-152). E-value:
                     8.3e-09. Score: 27.7. Matches aSDomain:
                     nrpspksdomains_ctg18_616_Polyketide_cyc2.1"
                     /NRPS_PKS="type: other"
                     /locus_tag="ctg18_616"
                     /transl_table=11
                     /translation="MDLCHDRAPYNQGIAVNDVKVQVIVKSPPSEIWKIWSNFSEAPLW
                     DTDVRQCRLDGPFQAGTRGQCVLKNGLNMPLKLEAVNLHESYRNSARLLWIDLEFDHQM
                     RRLSADETHVIHSAKISGPLSFLYRGLLRKALTAAMTTALDNLCTLAEQRALGTSRHEK
                     IATPLHLV"
     aSDomain        8482..8883
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg18_616_Polyketide_cyc2.1"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="8.30E-09"
                     /label="ctg18_616_Polyketide_cyc2.1"
                     /locus_tag="ctg18_616"
                     /protein_end="152"
                     /protein_start="18"
                     /score="27.7"
                     /tool="antismash"
                     /translation="VKVQVIVKSPPSEIWKIWSNFSEAPLWDTDVRQCRLDGPFQAGTR
                     GQCVLKNGLNMPLKLEAVNLHESYRNSARLLWIDLEFDHQMRRLSADETHVIHSAKISG
                     PLSFLYRGLLRKALTAAMTTALDNLCTLAEQ"
     CDS             9028..9726
                     /locus_tag="ctg18_617"
                     /transl_table=11
                     /translation="MNLQKKTQYLVMGIVGLGVIAPASSFADTLGPYVSAMGGVNWVAD
                     QDLTQNDNDFVEMEFNQPLHSGFATGLALGWRFPVGLRPELELSYRRNTLDQFNNRVYE
                     GGSSIEGKGEEQASSLMANLWYDIPNLPAPLSRFTPYIGGGLGYAVLTIKGLEAGGVEF
                     GGTHRDTVSAWQLGTGVGYELNEHWSMSLDYRYFKTREANFGKIQGLPQVDVETQYNTQ
                     SLMLGLRYWL"
     CDS             complement(9832..10497)
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 92.9; E-value:
                     2.6e-28)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg18_618"
                     /transl_table=11
                     /translation="MGRDERRVSGRKICRIIVADEHPLFREGMMVLLERLIPDAMIEQA
                     GNLEEVRTLATNGQPLDTLILEIRLPGLGSVSELAQLRQELKHTSMIVVSTLDDGDIID
                     RVMATGVDGFVGKSLSPDQVGKAIDDIRRGEVLVRYEPSDPLPLGSNDDMSKLTSRQRE
                     VWKLIAEGKTNKEIAAALEISPFTVRIHVSSLIRALNVPNRAVAAARFAGRQTPATLR"
     CDS             complement(10484..11266)
                     /locus_tag="ctg18_619"
                     /transl_table=11
                     /translation="LKSIPARKSNICLAYRKRLATVFAASALAVSGWGSSIAVASASTA
                     SETSSAACTNEADFQAGTVVEYESRDNLSSAISRGKTETLGREVFAGANPVASAHTSFL
                     NNAPFFVTTTFAEIKDGRLVRYGDRHGAGASLVTTTYLPPASTPIDLQPGQTVTVSYKN
                     KAVSAGATVEFDVVEQLTYNGRETIKTALGTFDTCKFTNEISTGSASANQPKNVVVVQN
                     WFPADGPYRGQSIRSVTPPAHGVAQRITEVVKMQYGTR"
     CDS             11507..11935
                     /locus_tag="ctg18_620"
                     /transl_table=11
                     /translation="MTESLERFVQAQASTYDHALLELRRRRKEGHWMWFIFPQLRGLGV
                     SENATYYGLRGMEEAREYLHHPLLGPRLERATRAVLDSEVATEKLLGALDAMKFASCMT
                     LFAAVAGEHSVYTQALDGGVSVDSRTLELLREQERKNV"
     CDS             11928..12407
                     /locus_tag="ctg18_621"
                     /transl_table=11
                     /translation="MSNYETWTLVVQVAVALVALLSMYLVVRQVVILTAQLKATQQASE
                     AQSIISIVEFLQASQARDARQAVRATLSTLHHDQWDATHVQHASLTCANYDVVAALLRA
                     DLIKNKHIIIENWAPSIKHCHQILAPFIETKRAQPGGDRKYWSNFDWLRDQCSQV"
     CDS             12423..13178
                     /locus_tag="ctg18_622"
                     /transl_table=11
                     /translation="VNSEAIFAQTVMRLRTARHLAIFTGAGISAQSGISTFRDPSTGLW
                     ARYDPKKLATPAAFAKDPALVWAWYSWRRTLVNEAQPNAAHLAVARLTQCLPRATVITQ
                     NVDDLLERAGSKEVIHLHGDLASARCFQCNRPYLGPLPVDVGPDCDSLEPPRCPHCDGQ
                     VRPNVVWFGEGMPEQELDQAFTAARDCDVMLSIGTSGNVYPAARIPTLATEHGAWLVHI
                     NIEPMGSASDKTLVGDATQWLPRLVDALG"
ORIGIN
        1 ttgcctggag acaaagtagc gctggtgctg cccaatgggg tggcgttcat cgcttattac
       61 ctggcgatca tcgggcgggg tgcaattccg gtcatcctca actacaagtt gactcccttc
      121 gaaatgaaca gcgtcgtcag tctcgccagg ccgatgctag tggtcacgac cgaagcgcta
      181 tgggggcaac acagtgaggt gttccaggct gacaacggcg tcaggcactc cctgctggtg
      241 gacggtgaga gcgaaccgtc atcgcccctg cccgccaaca caacggccat ctctcaactt
      301 cctcgccaga tcgagccctt gttgttgccc gagggcaatc cgatcgtctc ggtacagttc
      361 acctatcgtg gtatcggcag gcctctggct gtttcgcacc gttatctgga cctgacgcaa
      421 tcgagcgatg ggctgcatga gcagtttcat ctgcaaggcg tcggctccgt tcatctggtg
      481 acgctgccgc tgtatgccat cttcggcctg tcggtgatga tggtgtttcc cttgagcgtg
      541 ggcgccaccc tgctcatgac caacaccctg ctcaaccgag acctggcaga agtcctgtcc
      601 gaacatcagg tcacctttgc ctgcctggtg cccgatgtca ttcgctactt caatacgcgg
      661 ctggccaagc gcaaaggcgc gctcttgccg ttgcacccgc agttgatgat ttactccggc
      721 ggcagtcacc tgccggccga cgaagccgag aagctgggga agctgctggg atgcaatccg
      781 gtgctgcaag gctatgggtt gaccgaaagc atgcccgtga tcgtccagag ctcgattggc
      841 ccagtccacc gtggcgccat gggccagccg atcagcggtg tggaactgcg agtcgtcgat
      901 gcccagggcc aggacgtggc gccagggcgc atcggtgaac tactgatacg cggctcgatg
      961 gtgatcgacg gctacaacga tgccgaggac gccaatgcgc ggttcttccg cgacggctgg
     1021 ttccacagcg gtgacctggt ctggcaggac gacgatgggc atgtgttttt ctattgccaa
     1081 cgcctgcgaa tctccaagat caaggcgcag atggtcgacc tggtggaaat cgaatccatc
     1141 gctctcaagc accctgacgt ggtgcgcgcc aaagcctata tcgtcccgga ccacaaggaa
     1201 gtcaacgtgc tgcacctgtg cgtcgagggg accggcgagc tgacccagaa cgcgctttcc
     1261 accctgcttt cgcgctacct atcgggcttc aagctgccca agaccatcga gatcacttct
     1321 ctcaaggaag aggcacatgc acgctaacag cacacaaccg gtactggccg tcttcgactt
     1381 cgacggcaca ctgaccgacc ggcacacatt ctggcgctac atgcgcttta tcgtgggaac
     1441 ccgttcgttc tggctcagga tcattcccct gctgcccaag atgctcagcg tgatcgtggg
     1501 catcaccccg ctgatgcaag cgcgcctggc cttcattgcc tgttacctgg gcggcctgtc
     1561 ggtggagcaa gagcgcgagc atgccaagta cttcatcagc gagcagctgc cgctctggct
     1621 caggcccgag gcgttgcggc ggctgaagtg gcatcaatcc atgggacacg tcacggcgtt
     1681 ggtcagcaac tcgccggaga attacctgat cccctggggc caggccgcgg gttttgacta
     1741 tgtgtgcggc acccgcctgg caacggccaa gaacaagctg accggcggga tatccggtac
     1801 caactgtgta gagcgagaga aagtcacgcg gctcaaaggc tgcttgagca accttgatga
     1861 tttttacatt tatgcctacg gcgactcatc aggcgacgat gccctgctca gcattgccaa
     1921 ctcccccttc tacagaaact ggtactgatc gatgaacact ctgagcacgt tggcccccaa
     1981 gcatttcaag cgacctggca gcgccccgac cgtgatgatc gtaggtgccg gccctattgg
     2041 cctgaccctg gcaatcctgc tgaagaaatg gggcgtgtcg tttcgcatca ttgaaaagaa
     2101 cgccggcccc tcgacggcga ccaaggcaat ggccatccat tcccggaccc tggaaatctt
     2161 tcgcgacctg ggcgttgccg agcaagccat cagcgccggc ttcacgatca accagttttc
     2221 ggtgcagtcg aatgccaagc gggtgctgaa ctacaacttc tcctacctgg atgcgaccta
     2281 tcccctgctc ctgagcctgc cacagccgca aaccgagaaa attctccttg agcggctgaa
     2341 ggaactgggc gccgaggtgg aatggaatac cgaactggtg gacatcgaaa acctgccggg
     2401 ctcagtgcgc atgacgctca agcatgccga cggcaccgat gaaaacttca ccagtcgctg
     2461 ggtagccgcc tgtgacggcg ctcgcagcaa catcagaaaa cgcctcgaca tgaccttcga
     2521 aggttcatcc tacgatcgct tcttcatgct cgccgatgcc gatatccaat ggtccggaag
     2581 caaggatgag ggcgcgttct tcctgggtgc gcaggacggt tatgtggcgg ttgcgccgat
     2641 cagtgcccaa tcgcgttatc ggctgttcat cgaaatgccc tacaacctgc cgccagaagg
     2701 cgaacgccca tccttgagcc tggagaattt ccaacgcttg tgcgaaggac gcgggcaaaa
     2761 gatgacactg tcgaacattt catcgaccac catcgcctcc ttccagcatc gccgcgtgca
     2821 atcgatgcaa caaggctctg tgtttctgct gggggactcg gcgcacatcg gcagtcccat
     2881 cggcgggcag tggatgaacc tggggatttc cgaggcctat aacctggcct ggaaaatggc
     2941 ttatgtcgat caggacctgg cggatccgtc cttgctggac agctacaacg acgagcgcta
     3001 tccggttgcc ctggaagtcg agaacaccgc ccaccggctg acagggctga ttaccgtcag
     3061 gcgtcgcgcc ctggtctggc tacgcgacaa tgtcctgccc ctgttgagca accgcaacaa
     3121 ggtccagcgc aaactaccgg cgatgatttc cggtcatcag tatcactacg acaagagtga
     3181 ctacattcaa gaatcggtga cgaaaaaaca gcgccggaac tggaacaaga aaggcaagaa
     3241 acccgagttc cagagtgcac cgcctcgcgc cgggcaactg gcacccgatg tcgagttgtg
     3301 gcaactgcaa gggatgccgg caaaacgctt gatcgacttg ttccatggaa ccttcacgct
     3361 gttgattttc agcgcggccg accagttctc ccctttgctg ccaggctact acgcgctggc
     3421 cgagtcggtg gaaaaggact acccgggaat caaggcctat tgcgtgatcg atgccctgag
     3481 cagtgccggg ctgccggcct ggcactcgac actgctggac cccgattggc ggctgcacaa
     3541 gcgctaccac gccaaggaag gcatgttgat gctgatccgg cctgacggct atatcgcttt
     3601 cctcggcgcc gatgcaatga cgctggtgac ttatctgaac gtaaggtcgg ggttgctcaa
     3661 gggcgccaga aaaacaatat cttgcgagac cgacgcagtg gaactccaac tttaagtcgc
     3721 tccatgacta ctgccagttt gattaattga cataaacaag gccctgccct gggccatgat
     3781 ttcttgatct ttcttactta tagaaatttc gaccgacttg gttaggagat tcccatgcgc
     3841 ttgcaactta acgatgttgt acaggaattc atcgtgtcca atggaagaat agcccatagc
     3901 tatttctccc tttcagaaaa gatcattgat tcattgtgcg aatcgaatat cgccaaggaa
     3961 tcgatattac tgcggcttct ggaacaggcc gaaactgtca ctgcgcatta tttcaatgct
     4021 caccaacaag tccttgaagg cgtttatgcc aatgggatcg aagcccctgt cagcaagagt
     4081 atcgcggccc tggagccggt tcactcgaac ccgacaatac tggctccgac gcccgtagtc
     4141 gaagccgaag ccgaagccgt cgaacaggca gccgcgctca gttacggaca gtggttacgc
     4201 gccgaaatca gctcggtcac cgggttccag gcgcaacaga tcgactttga tcaaagcttc
     4261 gagagcctgg ggatcgactc gctggggctg gtggatattt tcgagtccct ggcccaacat
     4321 ttcccggaaa agaaagacct cacctcgcag ctcttcgatg cccctacccc gacagccttg
     4381 ctggcacggc ttgaagccga tccgcaggca cccgcggtgg acgtccaagc gtgggtagtc
     4441 gaccaactgg cgaccatcac cggctttacg gctgagcaga tcgacccgac acaaagctat
     4501 gaaagcctgg gcctggactc gctggtgcag ttggacttcc tggaagcggc agttgccatg
     4561 tggccgcagc tcaaggccca cagtagcgag ctggccaacg ccaagttccc gcaggccacc
     4621 atcgctctga ttcaagctgc cctggccgat ccccagccgc aggcagcgcc ctcacctgcc
     4681 gcgacggaca ctcaagggca ggaagaaaac ctgctgctca acgccctgtc cccgttgatc
     4741 ccggagacgg cgcagtcgat cgacctccag acgcccttcg cacaactggg cctcaacggc
     4801 tttgcccgag aggcgctctg ccaatccatg gcgcaacagt gctctgccag cgagtttgcc
     4861 ggtgaagcgt tgatgtcccg tcgcacgccc gaggatgccc tgtcgctgct gaccaggctg
     4921 agctagcagc gggcaacagg aatggaatcc gggtgatcga acaggtcacc cagcattttg
     4981 ggcgatcagg gagacagggt atgagtggcg cagtaacgac aacgggcgat ttttgcttca
     5041 gcgcgatggc gggcgagttt ccaggggcgc cgtcaacgga tgcgctttgg cagttgctct
     5101 cgcaagggca gatcgcaccg attgaatcaa tgccgacccg ttgggaattg gacaaggcat
     5161 cgatctattc aaccaaggca ggcgagaagg atcgcatcta tctggacagc gctttttgcc
     5221 tgatcgacga cgtgtcgacc ccatcacggc atgaaggaag acaggtcgcc atcggcaaga
     5281 aagtactcca ggcactgctt ggccaactgg ccggacaagg ctcggagctg aacaaggcgc
     5341 gtaccgcact ggtgatcgcg acatcctgga gtgacgagag ctatttcgcc accggaatgt
     5401 ccggaaaaac cgccacacca ccggggttta cacccggtga acaggtcgca gaactggctg
     5461 cgtcctttgc cttgggtggg ccggcgttat cggtggacac cgcatgcagt tcgttccctt
     5521 acgccctgga tatggcccag gcgctggtca acagtgggca ggcggacaac gcgattgtca
     5581 tggccctcaa caccgtgctg ccgccagcac tgttcctggg tttctcgcag ttgacggcct
     5641 tctccgcccg ggcccggatg gaagcgttcg gccaggacgc cgacggcatc gtgccgggcg
     5701 aatgtgcggt cgcctttctg gtcgagccgc tcgcccaggc cctgacggcg cagcgccgtc
     5761 ccctgggcgt cctgcgcgcc ttgggcatgt ccgccgacgg cgccgaaggc tcggtgttcg
     5821 cgcccggcaa acaggcccag tactcggcct accaacgtgc ctatcgtggt cttgatccac
     5881 gtgacgtgga ctacatcgag acccacggca ccggtactcc gctgggggac gcaacggagc
     5941 tggcctcgct gaacagcttc ttcgcccccc atcgcccgga cggcaagaaa atcaccatcg
     6001 gctcgatcaa gtcggtcatc ggccatcccc tggccgctgc cggaggtgct tccctcgcca
     6061 aggcattgat gatcctgcgc cataaaggca ttccacccca gcccggctac cgccccagca
     6121 ccaaggtcga cgagacctgc ctgcggctcg ccacccagca ggtgcaaccc ctggaggagt
     6181 gtcagtccgc gatccggatc ggcatctcca gttttggttt cggcggcgcc aacgcgcacc
     6241 tggtggtgga tgaatacatt cccgatgacc agcctgtcgc gccccagccg gcctcggcca
     6301 gcgcctgtgg cgtggtgaca ctggaccttg ccattgtcga ggctgaagca gcgctgggca
     6361 gccaccgctc cttgcagtca ttccagcagc aactcgatca accggccgcc ccctcggtca
     6421 cgttccctta tgggcgcttc gtcgattaca ccccggctcc cggccagcct ttgctggggc
     6481 aattcctcgc acaagaccac gtcatcgata tcgacggctt tggcatgggc cccaaaccat
     6541 tggctcatgt cgatccgttc aaactgttga tcaccgaccg cgtcaatcac ttgctgcgac
     6601 gcttgccggg ggtggccggt tcgcccggca cagcgatggt catgtgctgc aacatgggtg
     6661 gcgagcgctt cagcaatgcc tatagcagcg cccataactt ttacgcccag gcacaaggtg
     6721 cggcaccggg cgtcgaagtg acggacgtgg caaccatgct gccgaacatg ttgtccggtt
     6781 atccggcgca gattttcgac ttcaagggtt tccatcagac cctggtcggc acgacgggcc
     6841 tgttctggca aaccttgctg gcctcgccac aatggttcaa cgacggcatc accacgctcc
     6901 ttctcggcgc aggacgcttt gtcagcgctg aagtagaagt agagcgtgcc cggtgcagca
     6961 caaccaccga gggtgaaggt ctggggctgg tcgcgctgcg tcgttatcaa ccggatgccg
     7021 ccgacaaacc cttgctggtg atccacgctg cggtcctcgc ccacgccgcc gactcgttgg
     7081 aagaggcttg ccgacggttg ggcaaggagc cgagcgacta ttcgaacgtc gaagtctgcg
     7141 agttgcaacc tgttgcggcg cccgccagcg gctcactgcg ggagctgacc ggcttcctgg
     7201 ctgaagccag tggcatcgag actctgttgg cggtgatgtt gaggggcgcg cgccataccg
     7261 tgatcgaggt gcgcgacgcc ggcaagacgg tgatgtggct gtttaccgag aagcttcgcc
     7321 aatggaaccc gacagcggcc gaggccagtt cgcctatcaa gcatcccttc atgttgcgct
     7381 ttgcccattc gtcatcccac gaactgcagc aagtcatcac gcctgtcagc ctggttcgcg
     7441 aaccgcagaa cgatggcgtc gacgtgcagc aactgagcga catgctcacc agcaccctgc
     7501 tctccgggct gcgggtacga gtacgcgcga tggaaagcct gttcgccctg caccggggcg
     7561 acgcaaccca gcgcccggca cactggcagc gcagcgcgga acatatcgtg atcgccaatg
     7621 cccagcgcaa ccctcagtcg ctgcacgccc agctcgtggt gaatgaagcg cacccgtact
     7681 tcttcgatca tcccctggac cacatcccgg gcattttgtt gctcgagggt gtgctgcaac
     7741 tgatcgaact ggccatgccc cctctgagcg gacgcgttgc ctacatcaag agcctgacga
     7801 tcaagttcca gcaatacgta caaaagcagg gcgtgatcga tctgcacgtc gagcaaggcc
     7861 aggatcccca gatgttcaat gccaaggtca tgcagggcgg gaaagtgatg tgcacctgcg
     7921 tcctcgggat ggcctacagc tcggcgttcg aaacatcgcc agccggcgag ttcaccgcca
     7981 cgccctgccg cgacaaggcc ctgctgcaca aggccaggga agagaacgtc atcgtcagtg
     8041 acatgagcgg cgtcgcccag ggcctgagcg tggacaccgt gaaactgccg ccggaacact
     8101 tcttccaggc aggtgatccc gcgcactatt cgatggtgta tttcctcgaa gtggcgcgcc
     8161 agtgctacat gcagatcgct cacagccatc tgcgcattcc actcaatacc ccaatgaatc
     8221 tgctggcatt gagcttcacc ctggatcgcc ccatccccag gaacagcccg ctgtcattgg
     8281 cgccgcaagc cggttttgat gcgtcgctcc aggcattcaa gaccaaccgc atctatatcg
     8341 acctgttcaa ccggggcgaa aaaatcggtc aagccaacat taccgcccag gtgctgagtc
     8401 aatcggcgcc ggccgcctga acattgaatg gatctgtgcc atgaccgtgc cccctacaac
     8461 caaggtatcg ccgtgaacga cgtcaaagtg caagtcatag tcaaatcgcc cccttctgaa
     8521 atctggaaga tctggagcaa tttttcagaa gcgccgttat gggataccga cgttcgccag
     8581 tgtcgactcg acggtccgtt ccaggcggga acgcgcggcc agtgcgtcct caagaacggc
     8641 ttgaacatgc cactgaaact ggaagccgtg aacctgcacg aaagctatcg caacagcgca
     8701 cgactgcttt ggatcgacct cgaattcgat catcagatgc gcaggctttc tgccgatgaa
     8761 acccatgtca tccatagcgc gaagatttcc gggccgttga gtttcctgta tcgcgggttg
     8821 ctgcgcaaag cgttgactgc ggcgatgacc accgcactgg acaacctgtg cacgctggcc
     8881 gaacaacggg ccctcggcac ctcgcggcac gagaaaatcg cgacgccttt gcatctcgta
     8941 tgaacccttc cggatggctg cgtgctgaac gcgccctccc cgactcgctt tgcttactta
     9001 tcgataacag tacatttcgg atctagcatg aacctacaga aaaaaactca gtatctcgtc
     9061 atgggcatcg ttggcctggg tgtcatcgcc ccagcatcga gtttcgccga cacactcggc
     9121 ccctatgtca gtgccatggg cggggtgaac tgggtcgctg accaggacct gacccagaac
     9181 gacaacgatt tcgtcgagat ggagttcaat caaccgctgc actctggctt cgccaccggc
     9241 ctggcactgg gctggcggtt cccggtcggg ctacggcccg agttggaatt gagctatcgc
     9301 cgcaacaccc tggaccagtt caataaccgg gtctatgagg gcggaagcag catcgagggc
     9361 aaaggcgaag agcaagccag cagcctgatg gccaacctct ggtacgacat cccgaacctg
     9421 cctgccccct tgagtcgctt cacgccttac attggcggtg gcctgggcta cgcggtgctg
     9481 accatcaagg gcctggaggc tggcggcgtc gagttcggcg gcacccatcg cgacaccgtc
     9541 tcggcctggc aactgggcac cggcgtcggt tacgagctca acgagcattg gtccatgtcc
     9601 ctggattatc gctacttcaa gactcgcgaa gcgaacttcg gcaaaatcca gggcctgccc
     9661 caggtcgatg tggaaacgca gtacaacacc cagtccttga tgctcggcct gcggtactgg
     9721 ctgtaagcac tggacggatc ggcgccttgg gtgccgattt gcccttcatg acagattgcc
     9781 gctgtgcaca cttggtatgc gcgcgcctgt tccaaggctt gtgggtttcc gtcagcgcaa
     9841 ggtagcaggc gtctggcgcc cggcaaaacg tgcagcggcc accgctctgt tggggacatt
     9901 caacgcgcgg atcaacgaag agacatgaat gcgcacggtg aagggagaga tctccagcgc
     9961 cgcggcgatt tctttgttgg tcttgccttc ggcaatcaat ttccagacct ctcgctgccg
    10021 ggacgtgagc ttgctcatat catcgttgga gccgagcggc agcgggtccg aaggctcgta
    10081 cctgaccagt acttcccccc ggcgaatatc atcgatggcc ttgccgacct ggtcgggaga
    10141 aaggctcttg ccgacaaacc cgtctacacc ggtcgccatg acacgatcaa tgatatcgcc
    10201 gtcatccagg gtcgaaacca caatcatgga ggtgtgcttg agctcctggc gcaactgcgc
    10261 gagctcgctg acggagccca ggccgggaag acgtatttca agaatcagtg tatcgagcgg
    10321 ttggccattg gttgcgagcg tccgtacttc ctccagattt cccgcctgtt cgatcatggc
    10381 gtcaggtatc aggcgttcca gcagcaccat catcccttcc cggaacagcg gatgttcgtc
    10441 ggccacgata atccggcaaa tcttccggcc cgagacgcgt ctctcatcgc gtcccatact
    10501 gcatcttgac gacttcagtg attctctgtg cgacaccatg ggcgggaggc gtgacggatc
    10561 ggatcgactg accacgataa ggtccgtccg cgggaaacca attctgcaca acgaccacgt
    10621 ttttgggctg attggcggaa gccgagccag tagagatttc attggtgaac ttgcaggtgt
    10681 caaacgtacc gagggccgtc ttgatcgttt cacgaccgtt gtaagtcagc tgctcaacga
    10741 catcgaactc aacggttgcg ccggcactca ccgccttgtt tttgtagctg acggtgacgg
    10801 tctgccccgg ttgcagatca atcggcgtgg aagcgggagg caggtaggtg gtggtcacca
    10861 acgatgcacc ggcaccatgg cgatcaccgt agcgaaccag ccgaccgtcc ttgatctcgg
    10921 cgaacgttgt cgtcacaaag aacggcgcat tattgaggaa cgaagtgtgc gccgaagcca
    10981 ccggattcgc gccggcaaat acctcacgtc ccaacgtctc ggttttaccg cgactgatgg
    11041 ccgacgacag attgtcccgg ctttcatact ccacgactgt cccggcctga aaatccgctt
    11101 cgttggtgca agcggcagag gacgtctcac tggccgtgga tgccgacgca acggcgatag
    11161 aagaacccca gccactgaca gcaagggccg aggcggcaaa gaccgttgcg aggcgcttgc
    11221 gataagccag gcagatgttg gactttctgg caggtatgct tttcaaaaaa caggtccttg
    11281 ttcaaatgtg ctcgttgcaa ccggtcgaaa acccgacagc gctcataggt tagggtcgag
    11341 taccgagcgg cgctatagcg caagtgtgct atagggtttg cccttgcctg gggggtgatg
    11401 gtcaaggcta ccgatacgcg cccggccatg gcatcataag gccactattt tgttagagcc
    11461 tggacgcgct tcattcttca gccttgaaac cgtatcagag gctcacatga ccgaatcact
    11521 ggagcgtttt gtccaggcac aagcctcaac ctatgaccac gccttgcttg agttacggcg
    11581 tagacgcaag gaaggccact ggatgtggtt catctttccc caattacgcg gcctgggtgt
    11641 cagtgagaac gccacctact atggcctgcg cggcatggaa gaggcgcgcg agtatctgca
    11701 tcacccgctt ctgggaccgc gactcgagcg cgcgacccgt gccgtactgg actcggaagt
    11761 cgctacagag aaactcctgg gggcacttga tgccatgaaa ttcgcatcct gcatgacgct
    11821 ttttgcggcg gtcgcgggcg agcactccgt gtatacccag gcgctggatg gtggggtgag
    11881 cgtcgactcg agaacactgg aattacttag ggagcaagag agaaaaaatg tctaattacg
    11941 aaacatggac gttggtagtc caagtggccg tggccctggt ggccttgcta tcgatgtacc
    12001 tggtcgttcg ccaggtggtc atcctgacgg cacaactgaa agcgactcaa caggcttccg
    12061 aggcccagag catcatttcg atagtcgagt tcctgcaagc cagccaggcc cgcgatgccc
    12121 ggcaagcggt tcgcgccaca ttgtcgaccc tgcatcatga ccagtgggac gcgacccatg
    12181 tccagcatgc atcgctgacc tgcgccaact acgacgttgt cgcggcgcta ttgcgtgccg
    12241 acttgatcaa gaacaagcac atcatcatcg aaaactgggc gccgagcatc aagcactgcc
    12301 accagatcct tgcgcctttc atcgagacaa aacgcgccca gcccggcggt gacagaaagt
    12361 actggagcaa cttcgactgg ttgcgcgacc agtgctccca ggtctgacgt ggggatggaa
    12421 ctgtgaattc agaagccatt ttcgcgcaaa cagtgatgcg tctgcgaacg gccaggcacc
    12481 tggccatttt taccggggcc ggtatttccg cccaaagcgg tatctcgacg ttccgtgatc
    12541 cctcgaccgg cctctgggcg cgttacgacc caaagaaact ggccaccccc gccgccttcg
    12601 ccaaagaccc tgcgttggta tgggcatggt acagctggcg ccggacgctg gttaacgagg
    12661 cgcaacccaa tgccgcgcac ctggcagtcg ccaggctcac gcagtgcttg ccccgtgcga
    12721 ccgtcatcac gcagaacgtc gacgacctgc tcgaacgagc cggatccaag gaggtgattc
    12781 accttcacgg cgatctggcc agtgctcgtt gcttccagtg caatcgtccc tatctgggcc
    12841 cattgcccgt ggatgtcggc ccggactgcg acagcctgga accaccgcgt tgcccgcact
    12901 gcgacggcca ggtccgcccc aacgtggtct ggttcggcga agggatgccg gaacaggaac
    12961 tggaccaggc gttcaccgct gcccgtgact gcgacgtcat gctctccatt ggcacctctg
    13021 gaaacgtgta cccggcggcg cgaattccca cattggcaac cgaacatggc gcctggctgg
    13081 tgcatatcaa catcgaaccg atggggtccg cttccgataa aacactggtg ggcgatgcga
    13141 cccagtggtt gccgaggctg gtcgatgcgt tgggttgaag tgtcgccggc aaggcttgcc
    13201 cgacaccgct gaactgaacc aggacgtcgc cacccaggcc gcgttgcagc cacgcggtaa
    13261 cgctgcggcg aaacctcagg attggaacgt cgggagttct acttgaatgg ttttacccat
    13321 ctggaagaac tcccggtttt gtggtcacaa gacggcgcat caggcacaaa cccgcaccgc
    13381 tcaaggacct tccttgagcc gacgttgttc tcatagacat
//
