LOCUS       c00183_3300025..       14271 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300025547.a:Ga0209556_1001195.
ACCESSION   c00183_3300025..
VERSION     c00183_3300025..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 12:30:36
            Original ID  :: 3300025547.a:Ga0209556_1001195
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14271
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..528)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg183_1"
                     /sec_met_domain="AMP-binding (E-value: 5e-27, bitscore:
                     84.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEAKYTGASGEQLTSTIGQHLDSVSANDPNHPALIVPHQNIRWS
                     YAEFVAEVDRFATGMLALGIAQGDRVGIWSPNRYEWVVTQFATAKIGAIMVCINPAYRL
                     YELEYSLNKVGCKVIIAAESFKTSYYLKMLEELAPELAHCEPGRLESKKLPQLEIVIRM
                     GDEASDGMFNFES"
     protocluster    1..14271
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:6128]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..6128
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..14271
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14271
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             complement(737..1294)
                     /locus_tag="ctg183_2"
                     /transl_table=11
                     /translation="MALKPTIYKMTIDLSDLERSKYQTLNLTVAQHPSESVERMMARVL
                     AYCIDAHEQLEFTKGVSATDEPDLWQHTLDGQLCLWVEIGEPSFDRIKKSVRASKNVKI
                     YSLNTKSDVWWGQLEKKLMNLHLWVYRLQWTDVQALAALVQRTMNFSITITGNSAYIAA
                     ELGQTEIGWEVLKSGPAELYKG"
     CDS             1316..1519
                     /locus_tag="ctg183_3"
                     /transl_table=11
                     /translation="MIKQVCQSFLNVTQRLKILALIRKDEHALVTMVLTTIVLTTMVLI
                     ADPDGGFSDEANTTLKGVSQVA"
     CDS             complement(1607..2962)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 218.6; E-value: 2.2e-66)"
                     /gene_kind="transport"
                     /locus_tag="ctg183_4"
                     /transl_table=11
                     /translation="MSPPAADRTNQLLTAPLLPLLLKMASPNAAAFLVQATVNMTEVWY
                     VGQLGKVSLAAMALMFPLLMLTQMLANGAMGGGVTGAVARAMGAHNTDTAERLIWHALA
                     IALVAGFGFLILVLVALEPLLSLMSNDPAVLAQARLYAVILFSGCPLIWSTALLNSVYR
                     GMGNMKFPAMLMFLGAFIQIPLSGTLVLGWFGVPSLGIAGAAVSVITVAAFSNILLIRG
                     LLQDRSPLKLRRSARQLEPSLFASILRVGLPSSISPILTVSTLSGLNIFVGSFGVAALA
                     GYGIGSRIEFLIIPLVFGIGVSMNALVGVNLGAGQVQRAVNIGWVGAGTAAFFTGIGGL
                     AVALWPEAWASIFTDDVQTLASAKGYLQYVGPFFAFQGIGLSLFFASQGAGRMTWPLIA
                     AAVRLMIGIGGGAVLLYGYDASLNMVYLASGIAMVANGVITAGALKMGMWQR"
     CDS             3322..3972
                     /gene_functions="regulatory (smcogs) SMCOG1071:GntR family
                     transcriptional regulator (Score: 140.5; E-value: 1.1e-42)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg183_5"
                     /transl_table=11
                     /translation="MSHAAEHAYRTIRESILSGEFAPNGRLKEADLVAQCGFSRTPVRE
                     ALRRLASEDFVSLNRNQGAQVKAWTMDDINDLFQLRALLEGYSAARAADCITLIQLNKL
                     RESIKKMDEVLGSNASADKKVEDFLIHNNIVHTSIWQAAGSERLESMLGRLIDQSLVIR
                     TARKYSLERIAQSHHHHEELLKSLTAHDAQWSESIMRSHIHAARDALLVNDEN"
     CDS             4015..5226
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189:L-carnitine dehydratase/bile acid-inducible
                     (Score: 364.2; E-value: 1.2e-110)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg183_6"
                     /transl_table=11
                     /translation="MNTPLSHIRLLDLTHMLSGPYAGMILADLGCDTVKVEPPGIGEGT
                     RRLLEDDPNNSIKGMGAYFFTLNRNKRSVAIDLKSDEGRKYFFELVKVADVVLDNFAAG
                     VTSRLGVDHKALTAINPGIISCTVSGFGESGPRFKRPAFDQIVQGLGGGMSITGSGPED
                     AVRAGIPIGDLAGGMFAVMGIQAALLSKAQTGEGQHIDISMLDCQISLLNYMATMYSMS
                     GDIPTPIGNSHFVHTPYNTFNTADDQIIIAVIGDKFWPAVVELLGIEELDTPKFATAKA
                     RLAEKSFIEGRIGDVLIKETADHWLMELEKARIPCARVNNLAQALSDPQVQFRNMVVEL
                     EHPEGGTASVPGNPIKFSETNDENFTSPPLLGVHTKEVFREWTDMTDQQITAGIQAGFI
                     AGGD"
     CDS             5226..6128
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 204.2;
                     E-value: 6.6e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg183_7"
                     /sec_met_domain="HMGL-like (E-value: 2.5e-46, bitscore:
                     147.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEQVIVNDVGPRDGLQNDSTLVTPEDRVRLINSLLDAGVRSIEAA
                     SFVSPKAVPKMANADQVFAALDQEAADFSALVPNLKGYELAKKAGARSVAVVLSATETM
                     NQKNINMSLDQTISVCKEIVAQALRDGITPRSYLSVAVECPYEGMVEEQVIEGLSAMML
                     EAGAKEVIVADTIGAANPAQVKSLFTRLVSAFGAPTISGHFHDTRAMALANTWQALECG
                     IRKFDASIAGLGGCPFAPGASGNLATEDLVLMLNDAGFDTGIDLNKLLRSVELTGQLVQ
                     HPVGGRSMAYLNRRTENQQ"
     CDS             6165..8240
                     /locus_tag="ctg183_8"
                     /transl_table=11
                     /translation="MTFKLGVDVGGTFTDALLVNQDSKETYTAKVPSTPEDSSIGVINS
                     IVRVCASAGIEPSVISQVTHGTTVATNAILTGRGAKVGLITTRGYRQILQIARSYVPGG
                     LGGWVVYDKSAPLAPLACTAEIPERVAADGSIVSALDEAATRNALKHLGELGIEALTVS
                     LINSFANPAHEIRVAEIAREIMPDIPVSISSAVIPEMQEYERTITTVANSYVRPVVSSY
                     INNLQKELDTRMDSPHLSILRSDGGLSTVKAAEQFPVNLLMSGPAGGVTGALWVGKQTG
                     YKNLLTFDMGGTSTDVSLVENYKALLRRETTVGDVNVRASSLDVRTVGAGGGSIAYVPE
                     LTGALRVGPDSAGAEPGPAAYLKGGELPTVTDANVVLGYLPAEQKLGGDMAISREAAEA
                     AVQTIADSMKLTLKQAAEGIVKIVNENMFGALRLVSIEKGYDPRNFALIAFGGAGPLHG
                     NALGALMQSWPVIVPPGPGVLCAFGDATTRMRDEASRTFISRLDRTKPRTIVEELLKLE
                     ESAKNALLATDTNHSSDISSSDVTSQLQVDLRYSGQGLVLTIETSQQELLDQGFAGISE
                     RFDALHDQLFTFSLSAEKELVNLRVVVEGPESDIGVMAKTPDGGSVEDAVIGDHTIYAE
                     GRDHPAKLYERARLGTGHLIPGPAVVMEMDSTTLILPGHFARVDEQGNLIIRPSES"
     CDS             8251..10119
                     /locus_tag="ctg183_9"
                     /transl_table=11
                     /translation="MNSKIIQTNQQPFERVDVDPITLDIIENALRNARIEMDATLFRTA
                     MSPGIREQGDAFPMIANVEGKMVVGQFGSFIKGFLDVYDGTLEEGDMIFTNDPYSCGAA
                     VSHLNDWLVMKPIFKDGRHLCWAAHFGHMTDIGGKVPGSLPIDAREIFEEGVAVPPVKL
                     FRKGERQEDIIKIVLRNSRMPHWNEGDFNGVIAACNMAERRCIEIAERFGDDVFNSTLT
                     ELLDRNCRAMAKLIQATVPEKKQVFEDYICDDGIGMGPYKIKCAMWREDDTVIFDFEGT
                     DPQSSGSINFLLNEEMFKMFCGTFMISVFDPQILFNDGFYDYMDVRIPEGCILKPKRPA
                     ALSCRTHALGRIFDVISGLLGQGSPEFLCAAGFSDSPHLMYSGYDSKGEWYQLFQIGFG
                     GIPGRAGGDGPDGHSLWPGFTNVPNEYIEAYFPLRIEVYETISDSGGAGYNRGGNGIRM
                     AYRFLEDGQISIHDDRWLTYPWGVNGGAPGERGTKRLVRADGSEQILPSKCDRIAVMKG
                     DLLYFNTWGGGGVGDPLTRELDRVKTDVISGLVTVEGATRYGVVLDTLGNINQAATTSL
                     RNEMAANRKELPLFDFGGTIEEIKARCLEETGMEPPTQPVFANQPG"
     CDS             10125..10712
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:isochorismatase (Score: 73.1; E-value: 3.4e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg183_10"
                     /transl_table=11
                     /translation="MSAQLQSQSTGIGKRPCLLVVDATRGFTDPSSPLGADYSSELAVI
                     ADLMRHANIRSWPCYLSTVIYREEATASVFRTKLPALNGLTPDSEWIAIDPSLPVLDNN
                     VIIEKSYASAFFATDLGQCLKTLNVDTVIVTGFTTSGCVRASAVDALQWNFKVVVVQDA
                     VGDRNDQAHEANLQDLGLKYADVVGSEEISRI"
     CDS             10803..13436
                     /gene_functions="transport (smcogs)
                     SMCOG1107:TonB-dependent receptor (Score: 381.9; E-value:
                     8.8e-116)"
                     /gene_kind="transport"
                     /locus_tag="ctg183_11"
                     /transl_table=11
                     /translation="MSKQITITFLLICTANLVGITAVSTSAFAESAVQLEEVVVTARRR
                     AELDQEVPIATSVFNQSTIKRARIERPADFINLTSNVSITDTANAGDTQVNIRGITSTR
                     DAEGTFAFVVDGVLITNPNGFNQELFDIQSIEILKGPQGALYGRNAVSGAILVNTVPPS
                     DEFESTIRIGGGTDGLQKFGLSISGPLSDSLRGSLSVMSREDDGQQKNEFTGQDDVVDF
                     VDEQNVRARLVWDVSDRLTLDAVVGARNVEAGAINFNAVFALSDAAGLFGDPALFKDVN
                     DHDFSFYFNTPGENEQENTFFSLQAAYELDKALLTATFSYDELDEYLLSDGTSAAFGLY
                     SFDILGAFSPGGPTVGPAQAACSDSYQDLLASGRFAPGNNAPFFAFPGSVPGQAADLGI
                     APFYGLNALLSPYTPSTCDGYQYQERNQESTSFELKIASLDDAPVTWMAGVYYSQIERE
                     VVVSYGADLGDGKFSRTPFVAGRTDLLFWDDFDTDVWAIFGLVEFEAATNHTIALSGRY
                     DVEDREVSNNVPNVPTATAFGGGLGPINPAYQFNDVIADRDDEFKQFQPKLSWRWAFRD
                     DASLYASYGVGFRSGGFNNIGSAALVESEYATIATRPANLRDEYDKEVSTAFEIGMKSQ
                     WLNNRLRINAAVFHTEVEDSQFFNFLAGGFGILRVVTNIDEVTLQGFEIDAKYLVNSNL
                     SLFGSVGVVDSEIDKNTNRPYTEGNDMPLTPDMTANIGAEWASEISSGVELVARVDWRY
                     TGETWFSTVQDDVTTNAFTDVSATYQGIGFVLGDVTQTPPGPGIPPGGIIGFGRSDYSK
                     GQRDSYDTVNLNISLNAENWSLTFWGDNVLDEEYLEEIIPAPEFGGYFIHPAKGESFGV
                     DFVYHF"
     CDS             13891..14271
                     /locus_tag="ctg183_12"
                     /transl_table=11
                     /translation="MGIPAEHDIKLAGADDIAAACDILGSAFSQDPLLKWLCERPDIYS
                     DLFRLDAECLYKHHHCIYLNREHTGAAMWLPPGISTKSAKLHWRMLPLGWNLVSKGGLK
                     RLVTRGGALEKVTLAAHPAEPHF"
ORIGIN
        1 agactcaaaa ttaaacatgc cgtccgaggc ttcgtcgccc atccggatta ctatttcaag
       61 ttgcggtagc tttttggatt ccagtcttcc gggttcacaa tgagctaact cgggggcaag
      121 ttcttctagc attttgaggt agtagctggt cttgaaactc tctgcggcga taatgacctt
      181 gcagcctacc ttattgagcg aatactccag ttcgtacaac cggtaagccg ggttgataca
      241 gaccatgatc gcgccaatct ttgccgtggc gaattgcgtc acgacccatt catatcggtt
      301 gggtgaccaa atgccgaccc tgtcaccctg tgcaatgccg agcgccagca ttccggtggc
      361 gaatcgatcg acttctgcaa cgaattcagc atagctccag cggatgtttt gatgcggaac
      421 aattaacgca ggatgattcg ggtcgtttgc cgacacacta tccaggtgtt gtcctatagt
      481 tgacgtcagc tgctcaccag acgccccagt atatttcgct tcacccatta aatgtgtacc
      541 ccacccttaa ttatcaagcc aattcgttaa atcattattt tactgtgagc agaatgaaca
      601 atattgcccc ggcaacctat ttactaaaat agtgcccatt aaggggcgac atcgaaatga
      661 actccgatca ccatgaatgc tagcagtgtg acgaagctgg ctcaagctgc ggtgtttctg
      721 aattggaagt attttgctaa cctttataca attcagctgg gccacttttg agcacttccc
      781 agccaatctc ggtctggccc aactccgctg caatgtaagc agaattgcca gtgatggtaa
      841 tgctaaagtt catggttcgt tgcacgagtg cagccagggc ctgaacgtcg gtccactgaa
      901 gtcgataaac ccataagtgc aggttcatca atttcttttc caattgaccc caccatacat
      961 ccgattttgt atttaggctg taaatcttga cgttcttcga tgcacgaacc gatttcttaa
     1021 ttcgatcgaa tgacggttca ccaatctcta cccaaagaca aagctgaccg tccagtgtgt
     1081 gttgccagag atcaggctca tcggtagcgc tgacgccctt ggtgaactcc agttgttcat
     1141 gtgcgtcgat gcagtaggcc aggacccgag ccatcattcg ttcaacagat tcagaggggt
     1201 gttgtgccac agtcaaattg agggtctggt atttactacg ttccagatca gacaggtcaa
     1261 tggtcatttt atagatcgtt ggttttagcg ccatggatgc tgttggcctc ggctaatgat
     1321 caaacaagtt tgtcagtcgt ttcttaatgt cactcaacga ctcaagatat tggcgctgat
     1381 cagaaaagat gaacatgcgc tcgttactat ggttctcact actatcgttc tcactactat
     1441 ggttctcatt gcagatccgg acggtggatt cagtgacgag gctaacacca cgctcaaagg
     1501 ggttagtcag gtggcataag ttcgtggcga tggacaatag agacccttgt cgggattgta
     1561 tctaatctta gccatcaagg ttgccgcgca gctcgtagcg taacggttag cgctgccaca
     1621 tccccatttt cagtgctcct gcagtgatga ccccatttgc gaccatggca atgccgctgg
     1681 ccagatagac catattcagt gaagcgtcat atccgtacag caaaacagca ccaccgccaa
     1741 tcccgatcat aaggcgcact gcggctgcga tcagtggcca ggtcatacga cctgccccct
     1801 gggaagcaaa aaacagggac aagccgatgc cctgaaaagc aaaaaatgga cccacatatt
     1861 gcaggtagcc cttggccgaa gccagcgtct gaacgtcgtc ggtaaagatt gaagcccagg
     1921 cttccggcca aagcgcgact gccagaccac cgataccggt gaaaaaggcg gcagtacctg
     1981 cgccaaccca accgatattc acggcgcgtt gaacctgacc cgcaccgaga ttgacgccta
     2041 ccaatgcatt cattgaaaca ccgatgccga acaccagcgg gataatcaga aattcaatgc
     2101 gagaaccaat gccgtaaccg gcgagagcgg ctacgccgaa tgacccgaca aaaatattga
     2161 gaccactgag tgtgctgacg gtcaatatgg gagagatcga ggacggcagc ccaacgcgaa
     2221 gtatcgatgc aaacagggaa ggctctaact gcctggccga ccgacgaagc tttaaaggcg
     2281 accggtcttg cagtaaaccg cgtattaaca ggatgttgct gaaggcagcc accgtaatca
     2341 ctgaaaccgc tgcgccagca atacccagac tgggtacgcc aaaccagcca agcaccagcg
     2401 tcccggaaag tggaatctgg ataaaagcac caagaaacat cagcatggcc gggaacttca
     2461 tgtttcccat ccctcgatag acagaattaa gcagcgccgt gctccagatc agcggacagc
     2521 cgctgaacag aatgacggca taaaggcgag cctgtgccag cacagccggg tcgttactca
     2581 tcaggctgag caggggttcg agtgcaacca gcactaatat gaggaagcca aatccggcaa
     2641 caagggcaat ggccagggca tgccagatca atcgttctgc ggtatctgtg ttatgagcac
     2701 ccatggccct ggcaacagcg ccagtgacgc caccacccat cgcgccattg gccaacatct
     2761 gcgtcagcat gagaagcgga aacattaacg ccatcgctgc gagggatacc ttgcccaact
     2821 gcccgacgta ccagacttca gtcatgttga ccgttgcctg cacaagaaag gcagcagcat
     2881 taggactcgc catcttaagg agcaggggca gtagtggcgc tgtcagtaat tggtttgtgc
     2941 ggtctgctgc aggcgggctc attgcttatc aggtcattgg gcgaaagtcg tagagtacgc
     3001 tatagcactc gttgcgcgag tgttttttct cttgattgct gagctattat tcagggtttt
     3061 caactatcgt ggatttcact ggctccttaa caaatcgtgg ccagtgttac ggtcaggcga
     3121 taatcgatgc atcaaactgg actaacgaaa ctggcggtat taacggtcga ttgattgatc
     3181 ttgataccgt tgaaacagcg tgcctggtca gacgagccat taatgcctaa cgttttgcag
     3241 acagccctat attgtataca atgctgatta tcagccttcg ctatcccaac tatttacccg
     3301 aggaagcaat caactcagtc catgtctcat gcagcggaac acgcctatcg cactattcga
     3361 gagagcattc tttccggtga atttgcgcca aacggtcgcc tcaaagaggc agaccttgtg
     3421 gctcaatgtg gctttagtcg tacgcccgta agagaagcac tgcggcgcct cgcttcagag
     3481 gattttgttt cactcaatcg aaaccagggt gcacaggtta aagcctggac aatggatgat
     3541 attaacgatt tgtttcagct tcgagccctg ttggaaggct attctgcagc gcgagcggcc
     3601 gattgtatta ccttgattca attgaataaa ctacgagaat ctatcaaaaa gatggatgag
     3661 gtcctcggca gtaacgcatc cgcagataaa aaggtcgagg attttttgat ccacaacaat
     3721 attgtccaca cttccatctg gcaggcggca ggtagtgaac gccttgaatc aatgctaggt
     3781 cgattaatcg accaatcgct ggtgatcaga acagctcgaa aatattctct ggaacgaata
     3841 gcgcagtctc accatcatca cgaagagctc ctgaagtcgc tcactgcgca tgatgcgcag
     3901 tggtcagaat cgatcatgcg gtcccatatc catgccgcaa gagatgcact gctcgtcaac
     3961 gatgaaaact aaattgtatg caataccgac catcaaagga ttaacagtaa atccatgaat
     4021 acgcctttgt cacacatccg cttgctggat ctgacacata tgctatcagg accttacgcg
     4081 ggcatgattc tggcggacct cggttgtgac accgttaaag tggaaccgcc tgggataggc
     4141 gaaggtaccc gccgcctgtt ggaagacgac ccgaataatt ccattaaagg tatgggcgca
     4201 tattttttca ccctgaatcg caacaagcga agtgtggcca ttgatctcaa atccgacgaa
     4261 ggtcgcaaat atttttttga actggtgaaa gtcgcggatg ttgtcctgga caactttgct
     4321 gccggtgtga cctcaaggct tggcgtcgac cacaaggcac tgaccgccat caacccggga
     4381 atcatttcct gcacagtgag tggattcggt gaaagcggtc caagattcaa gaggcccgcg
     4441 tttgaccaaa tcgttcaagg cctgggtggc gggatgtcca taaccggaag tggtcccgaa
     4501 gacgctgtcc gcgccggcat tcccatcggt gatctcgccg gagggatgtt cgcagtgatg
     4561 ggaattcagg cagctctctt gtcaaaggca caaaccggcg agggacagca tatcgacatc
     4621 tctatgcttg attgccaaat tagccttctg aattacatgg ccaccatgta ttccatgtct
     4681 ggtgatatcc cgacacccat cggaaattca cattttgttc acacgcccta caacactttc
     4741 aataccgcag atgaccaaat aattattgcc gttatcggcg acaaattctg gccagcggtt
     4801 gttgagttac tgggcattga agaactagat acccccaaat ttgccaccgc taaagcacga
     4861 ttggcagaaa agtcttttat tgagggcagg attggcgacg tacttatcaa ggaaacagca
     4921 gatcactggt taatggaact ggaaaaggct cgaatcccct gtgcacgcgt caacaacctg
     4981 gctcaggccc tttctgatcc acaggtacaa tttcgtaaca tggtggtaga gcttgaacat
     5041 cccgaaggcg gtacggcaag cgtgccaggt aacccgatta aattttcaga aaccaacgat
     5101 gaaaatttta cctcaccacc cttgctgggt gttcatacaa aagaagtgtt tcgagaatgg
     5161 actgacatga ctgatcaaca gataaccgcg ggtattcagg cgggttttat cgcgggaggt
     5221 gactagtgga gcaggtcatc gtgaatgacg tgggacctcg tgacggtctg cagaacgatt
     5281 caactttggt cacacccgaa gatcgcgtgc ggctcatcaa ttctttattg gacgcgggag
     5341 tcaggtcaat tgaagcggcc agttttgtaa gcccgaaagc cgtgccaaaa atggctaacg
     5401 cagatcaggt gtttgctgct cttgatcagg aggctgcgga tttcagcgcc ctggtgccaa
     5461 atctaaaggg ctacgagtta gcaaaaaagg caggcgcaag aagtgttgcg gttgttttat
     5521 cggcaactga gaccatgaac cagaaaaaca tcaatatgag cctggaccaa acaatctcgg
     5581 tttgtaagga aattgtcgcc caggcgctaa gagatggtat cactccgcgg tcttatctct
     5641 cggtcgccgt agaatgtcct tacgagggca tggtcgaaga acaggttatt gagggcctca
     5701 gcgcaatgat gcttgaagcc ggggccaagg aagtgattgt cgcagacact attggcgctg
     5761 ctaacccggc acaggtgaaa tcgctcttta ctcgccttgt atctgcattt ggggcaccga
     5821 caatatcagg tcacttccac gacacgcgtg caatggcact ggccaatacc tggcaggccc
     5881 tggaatgtgg cattcgaaaa ttcgacgcta gtatcgccgg tctgggtgga tgcccgtttg
     5941 cgcctggcgc ctcgggtaat ctcgccaccg aagacctggt ccttatgctc aatgatgcgg
     6001 gcttcgatac tggcatcgac ctgaacaaac tgctccgatc agtcgaactg accgggcaac
     6061 tcgtgcaaca cccggttggg ggtagaagta tggcttatct gaaccgtaga accgaaaatc
     6121 aacagtgagc ggagtgaatg tgaacgtcaa actggaaatg accaatgact tttaagctag
     6181 gtgtagatgt aggcggcaca tttactgatg ccctgctggt aaatcaggac tcaaaagaaa
     6241 cctacaccgc aaaggtccct tctacacctg aagactcttc aataggggtc atcaatagta
     6301 ttgtcagggt atgcgcgtct gccggaattg aaccgagtgt gatcagccag gtgacccacg
     6361 ggacgaccgt cgcgaccaac gcaatcctca cggggcgagg cgccaaagtc gggctcatca
     6421 caaccagggg ttatcgacaa attttgcaga tcgcgcgttc ttatgtaccc ggcggactgg
     6481 gcggttgggt ggtctacgac aaatccgcgc cgctggcacc actggcatgt acggcagaga
     6541 ttcctgaacg agtggctgcc gacggatcta ttgtgtcagc actcgatgag gcggcaaccc
     6601 gaaatgcctt gaaacaccta ggtgaactcg gcatcgaagc attaacagtt tctttgatca
     6661 acagttttgc caaccccgcc cacgaaataa gagtggctga aatcgccaga gaaatcatgc
     6721 ccgatatccc ggtgtcaatt tcctctgccg tcatacccga aatgcaggaa tatgaacgca
     6781 ccatcaccac cgtcgcaaat tcttacgtgc gccccgtggt ttcaagttac attaacaatc
     6841 tacaaaaaga actggatacc aggatggaca gtcctcatct ctccatcctg cgttccgacg
     6901 gcggtctgtc aacggtaaaa gctgctgaac aatttcctgt gaaccttttg atgagtggac
     6961 ccgcaggtgg cgttacgggc gctctatggg ttggaaaaca aacggggtac aagaatctac
     7021 tcacgtttga tatgggcggc acctcgacag atgtttctct tgttgaaaac tataaggcgc
     7081 tactgcggcg cgaaacgacc gttggtgatg ttaacgtgcg ggccagttca ctcgatgtgc
     7141 ggaccgtggg tgccgggggc ggctctattg cctatgttcc tgagctaaca ggtgctttaa
     7201 gagtggggcc agattctgcc ggcgctgaac ctggccctgc agcctatctt aaaggtggcg
     7261 aactaccgac agttaccgac gccaatgtcg ttctcggcta cttaccagca gaacaaaaac
     7321 tcggcggcga catggcaatt agccgggaag ccgccgaggc ggctgttcaa accattgcgg
     7381 attcaatgaa attgacactt aaacaggctg ccgaaggtat cgtaaagatc gtcaatgaaa
     7441 acatgtttgg cgcactgcgg ctcgtttcta ttgaaaaggg atacgaccct cgcaactttg
     7501 cgttaatcgc attcggcggt gcaggacctt tgcatggcaa tgcccttggc gcattaatgc
     7561 aatcctggcc ggtcattgtc cctcctggtc caggcgtgct ttgtgccttc ggagacgcca
     7621 cgacgcgaat gcgagatgaa gcgtccagaa cgttcatctc ccggctcgac cgcacgaagc
     7681 ccagaaccat tgtggaagaa ctgctcaagc tcgaggagtc cgctaaaaac gcattgttag
     7741 cgactgacac aaaccattcg tcagatattt cgagcagcga cgtgacatca caactgcagg
     7801 ttgatttgcg atactccggc caggggcttg tgttgacaat tgaaaccagt caacaggaac
     7861 tattggatca aggctttgcg ggaataagtg aacgtttcga tgcacttcac gaccagttgt
     7921 ttacgttttc actgagtgca gaaaaggaac tcgttaatct ccgtgtggtc gtcgaaggcc
     7981 cggagtcgga tattggcgtg atggcaaaaa cgccagacgg aggatccgtc gaagatgccg
     8041 ttatcggaga tcacaccatt tacgcagagg gccgggacca ccctgcgaaa ctctatgaac
     8101 gggctcgcct tggcaccggt cacctgatac ctggtcctgc ggtggtcatg gaaatggatt
     8161 caacgacgtt gatcctgcct ggccattttg cacgtgtcga tgaacaggga aatctaatca
     8221 tccgacccag tgaatcctga ggaattaacg atgaacagca agatcattca gaccaatcag
     8281 cagccgttcg aacgggtaga cgtagacccc atcacactgg atatcatcga gaacgccctg
     8341 cgaaatgcgc ggattgagat ggatgcaacg ctgttcagaa ccgccatgtc tcccggaatc
     8401 agggagcagg gtgacgcgtt tccgatgatc gcaaatgtgg aaggcaaaat ggttgttggc
     8461 cagtttggat cgtttatcaa ggggttcctc gatgtatatg acgggactct cgaagaaggc
     8521 gatatgattt tcactaatga tccgtacagc tgcggagcgg cggtctctca tctgaacgac
     8581 tggctcgtga tgaaaccaat ctttaaagat ggcaggcatc tttgctgggc agcccacttt
     8641 gggcatatga cagacattgg cggcaaggtt cctggctcat taccgattga tgcccgggag
     8701 atattcgagg aaggcgtcgc cgtaccgcct gtgaaattgt ttcgcaaggg agagcggcag
     8761 gaagacatta tcaaaattgt tcttcgaaac tcccgcatgc ctcactggaa cgaaggagat
     8821 ttcaacggcg tgatcgctgc ttgtaacatg gctgaaagac gctgtattga gattgctgag
     8881 cggttcggag acgacgtctt caattcaacg ctcactgaat tgctggatcg taattgtcgg
     8941 gcgatggcaa aactcattca ggctacggtg ccagagaaga aacaggtttt tgaagactat
     9001 atctgtgatg acggtatcgg catggggccg tataagatca agtgtgcgat gtggcgcgaa
     9061 gacgataccg tgatttttga ttttgaaggt accgatcccc aaagttcagg ctctatcaat
     9121 ttcctgttga atgaagaaat gttcaagatg ttctgcggca cctttatgat ttccgtattc
     9181 gacccacaga tacttttcaa tgatggcttc tatgattaca tggatgtccg aatccccgag
     9241 ggctgtattc ttaaacccaa aagacccgca gcgttatcct gtcgaacaca tgcactcgga
     9301 cgtatttttg atgtaatttc aggcctgcta ggccagggta gccccgaatt tttgtgcgca
     9361 gcaggtttct ctgacagccc tcacctgatg tattcaggct atgacagcaa gggtgaatgg
     9421 taccagttgt tccagatcgg gtttggcggc atacccggtc gggccggggg cgatggcccc
     9481 gatggccatt ccctgtggcc aggattcacc aacgttccca acgaatatat agaggcgtac
     9541 ttccctttac gcatcgaggt atatgaaacc atctctgatt ccggcggcgc cggttacaac
     9601 agaggcggca atggcatacg catggcgtac cgatttctcg aggatgggca aatatccatt
     9661 catgacgaca ggtggctcac gtatccctgg ggggttaacg gaggtgcacc tggggaaaga
     9721 ggcactaaac ggctggtcag ggcggacggt agtgaacaga tactgccgtc caagtgcgat
     9781 cgaattgccg tcatgaaagg tgatctgctt tacttcaata cctggggtgg cggtggcgtc
     9841 ggggatccgc taacacgcga actcgatcgt gttaagacag atgtaataag cggcctggtc
     9901 accgttgaag gcgccacgcg ctacggcgtg gtgctggata cgctgggcaa tattaatcaa
     9961 gccgcaacga cctcgttacg caatgaaatg gcagcaaacc gaaaagagct gcctttattc
    10021 gattttggtg gaaccataga agaaataaag gctcgctgtc tggaagaaac aggcatggaa
    10081 ccacccacac aacctgtttt cgcgaatcag ccaggttaac tgaaatgagc gcacagcttc
    10141 agtcacaatc aacaggtata ggaaaaagac catgcctgct ggttgttgat gctacccgag
    10201 gtttcacaga cccgtcatcc ccgctcggtg cagattattc cagcgaactt gcagtgatcg
    10261 cggatttgat gcggcatgcg aacattcgat catggccttg ttacctctcc accgtcatct
    10321 atcgagagga ggcgacggcg agtgttttca gaacgaagct tcccgcgttg aacggtctga
    10381 caccggattc agaatggata gccattgacc cgagcctgcc cgtactggac aacaatgtca
    10441 tcattgaaaa aagttatgcc tctgcattct ttgcgactga tctcggtcaa tgcctgaaga
    10501 cactgaatgt cgataccgtc attgtcacgg gttttacaac cagcggttgt gtgcgtgcga
    10561 gcgcggttga tgccttgcag tggaatttca aagtggtcgt cgtacaagac gcggtcggag
    10621 atcgtaacga tcaggcacat gaagctaatt tacaggatct gggattgaag tatgcagatg
    10681 tggttggaag tgaagaaata tcaaggatat agatattgaa aaagaacaat tcatacaagt
    10741 agtaaactgg aaataatcga cattcgtagc agctaagaaa gcataaactg atggagccaa
    10801 caatgagcaa acaaataaca ataacttttt tattgatatg tacagcgaac cttgtcggaa
    10861 ttaccgcggt cagcacctcg gcgttcgctg aaagtgcagt acaactcgaa gaagtggttg
    10921 taaccgcgag aaggcgagca gagcttgacc aggaggtacc gattgctacc tcagttttta
    10981 atcaatccac gatcaaacgg gccaggatag aaagaccggc tgatttcatc aatcttacgt
    11041 caaacgtcag tattactgac accgcgaacg ccggtgatac ccaggttaac attcgaggga
    11101 tcacttcgac gcgtgatgca gaaggcacat ttgcgtttgt cgttgatggc gtcctgatta
    11161 ccaacccgaa cggattcaat caggagctat ttgatattca gagtattgag atactgaaag
    11221 gaccacaggg tgctttatat ggtcgcaacg cagtgtccgg ggcgattctc gtcaataccg
    11281 tccctccttc tgacgaattt gaaagcacca ttcgtatagg cggtggtact gacgggcttc
    11341 agaaattcgg tttatcgatc agcgggccct tgagcgacag cctacgtggc agcctttcag
    11401 tcatgtctcg tgaagatgat ggccaacaga agaatgaatt cactggccaa gacgatgttg
    11461 tcgattttgt cgacgagcaa aatgtccgcg ctcgattggt ctgggatgtg tccgacagac
    11521 tcaccctcga tgcggttgtc ggcgcacgta acgtagaggc cggggcaatc aactttaacg
    11581 cagtctttgc gctatcggat gccgccggac tatttggtga tcccgctcta ttcaaagacg
    11641 ttaacgatca cgacttttct ttttacttca atacgcctgg agaaaatgaa caggaaaata
    11701 cctttttctc actccaggca gcgtatgaat tggacaaggc cttgttaaca gcgactttct
    11761 cctatgatga actcgacgaa tacctgctgt cagatggcac cagtgccgct ttcggacttt
    11821 attcattcga tattctgggc gctttcagtc cgggtggacc gaccgttggc ccggcacaag
    11881 ctgcctgttc cgattcatac caggacctgc tggcatccgg tcgatttgca ccaggtaaca
    11941 atgcgccctt ctttgcattt cccggcagtg ttcccgggca ggcagccgat cttggtatcg
    12001 cgccttttta tggtctaaat gccctgctct ctccctacac ccccagcacg tgtgacggct
    12061 atcaatacca ggaaaggaac caggaaagta cgagtttcga gttgaaaatt gcctcgttgg
    12121 atgatgcgcc ggtaacctgg atggccggtg tttattattc tcaaattgaa cgtgaagtgg
    12181 ttgtttcata tggcgcggac cttggagatg gaaaattcag tcgtacacct ttcgtcgccg
    12241 gtcgaacgga cctgttattt tgggacgatt ttgataccga cgtttgggcc atcttcggcc
    12301 tggttgaatt tgaggccgcg actaaccaca caatagcgct gtcgggtcgt tacgatgtcg
    12361 aagatcgcga ggtctccaat aatgtgccca atgtcccaac ggcaaccgcc ttcggcggcg
    12421 gcctgggccc aatcaaccct gcctaccagt tcaacgatgt gatcgcagat cgcgatgatg
    12481 aattcaaaca attccagcct aaactaagct ggcgttgggc ttttagagat gacgcatcac
    12541 tgtatgccag ctatggcgtt ggattcagaa gcggcgggtt caataatatt ggtagtgccg
    12601 cgctggttga atcggaatat gcgacgattg caactcgtcc tgcaaacctc cgagatgaat
    12661 acgacaagga agtgtctacc gcttttgaaa ttggcatgaa gtcgcaatgg ttgaataatc
    12721 ggttgcgaat caatgcagcc gtatttcaca ctgaagttga ggatagccag tttttcaatt
    12781 ttctcgctgg cggcttcggc attttaaggg tcgtcaccaa cattgacgaa gtcactttgc
    12841 agggtttcga gatagacgcc aagtatctgg tcaattcaaa cctctcacta ttcggttccg
    12901 tcggcgtagt cgatagtgaa atcgacaaga acactaatcg tccatatacc gaaggtaacg
    12961 acatgccgtt aactcccgat atgacagcca atattggggc ggaatgggcc agcgagatct
    13021 cgagtggtgt cgaactggtg gcacgtgtgg attggcgtta caccggagaa acctggttca
    13081 gtacggtcca ggatgatgtc accacgaatg cattcaccga tgtatcagcc acttaccagg
    13141 ggatcggttt tgttttgggt gacgtgacac aaacgcctcc tggcccaggc attcctccag
    13201 gcggcatcat aggatttggt cgaagtgact atagtaaagg acaacgtgat tcctacgata
    13261 ctgttaacct caacatcagc cttaacgcag aaaattggtc cctcaccttc tggggagaca
    13321 acgtactgga tgaggaatat cttgaggaaa tcattcccgc ccctgaattc ggcggttact
    13381 ttatccaccc agctaaaggt gaatcctttg gggtagattt cgtttaccat ttttgagtct
    13441 gttcgggggt gcagtctgac tgcatccccg catcgaccgt cgagtgatca aacagcccgg
    13501 ctgctggtaa gcggtttctg gtttgcgatg cctcattcag accaacgtgg ttccgggcac
    13561 tgccgtcaaa ttctcaatcg gacctctttg cagcttccca atcaactggc gatgacgtaa
    13621 gcagcgagct agagctgccc ccttcactta ctaacaagga gtattattca gtgttgcttt
    13681 ttcgatactc cacttaccga ccgaacaccc ctgtcaaaat ttctattttc taactggatt
    13741 tttggtactg tggctgcctt gggtttgtcg catcgcgtta tcgccgcggt taatagaata
    13801 accctgccga tttagcccaa tctttattca gtcaatcctg aatatacttt actttttcac
    13861 tgcacaatcc tgcagaggag tagcgcaacc atgggcatac ccgctgaaca cgatattaag
    13921 cttgccggtg ctgacgatat agcggctgca tgcgacattc tgggtagtgc attcagccaa
    13981 gacccattgc ttaaatggct ctgtgagcga ccggatatct atagcgattt gtttcgtttg
    14041 gatgctgaat gcttatacaa gcatcaccac tgcatttacc tgaatcgaga gcacaccggt
    14101 gcggcgatgt ggttgccccc agggatctct acaaaatccg ctaaactgca ttggagaatg
    14161 ttaccccttg gctggaatct tgtgagcaag ggtgggctca agcgcttggt aacgaggggg
    14221 ggtgcattag agaaggtgac gctggcagcg catcctgctg aaccgcattt c
//
