LOCUS       c00281_3300025..       11342 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300025797.a:Ga0210062_1000564.
ACCESSION   c00281_3300025..
VERSION     c00281_3300025..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 13:23:28
            Original ID  :: 3300025797.a:Ga0210062_1000564
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11342
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11342
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5427:10106]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C) or cds(LANC_like and (Pkinase or DUF4135)))
                     and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5428..10106
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C) or cds(LANC_like and (Pkinase or DUF4135)))
                     and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11342
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C) or cds(LANC_like and (Pkinase or DUF4135)))
                     and not (YcaO or TIGR03882))"
                     /kind="single"
                     /product="lanthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11342
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C) or
                     cds(LANC_like and (Pkinase or DUF4135))) and not (YcaO or
                     TIGR03882))"
                     /tool="antismash"
     CDS             2..1555
                     /locus_tag="ctg281_1"
                     /transl_table=11
                     /translation="DADCAAISCKADSDCPPNATCGANGTCQNVCQNTTCACSSAGPAC
                     PGAGTMCNLAADSSFGFCAGGACQYNGLVPENGAGTTSPQWELAATCSSDAQCAAEQTC
                     NDGQCTCGSNDDCTALGGTCSGGVCVGQTAVVCMPQGWGGRVWGRTGCAKAGDAFQCQT
                     GQCGAGASAVLECTDVAAGITQTATGVTLFEGTWDSNGVDFWDVSLVNGYNVPLQVAAF
                     VGGKAAPCTFAGTDFVGRPVGCESDLNDACPTPLQIAGKCNCVADADCPQGQTCGADNL
                     CSGAGGCTVVCIDPGDYCTSFGLYGNNPVITPPAALKCNDPVSTLNATTYNDYYSCTGS
                     LSELSCNNAAITCFADNDCPFYPDQVCQANVCMPVSVEDTLAQCVSGACNPKVNHVDQY
                     SCQTVQEMSLCLPKPPTSTAQSGCCGAYNPDWMTAAQAANGTPGGATFAEAFRTACPLS
                     YAFQFDDVASSFQCSNASGEVDYLVTFCPVAEPAKTEPAAPAQGPAEGGRVMALPSGRP
                     "
     CDS             complement(1724..2053)
                     /locus_tag="ctg281_2"
                     /transl_table=11
                     /translation="VLVEGDLYYALASGRTAPALLFDNGPDYFVEGRARTIRDGKVGFV
                     NEGLEVVVPREWDFALPFEGGFARVCTGCSIVREDGDEHGTVQGGSWAVIDREGRIVQE
                     VPDNP"
     CDS             complement(2257..3111)
                     /gene_functions="resistance (resist) NDM-CcrA (Score:
                     279.6; E-value: 1.2e-85)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     55.9; E-value: 6.9e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg281_3"
                     /transl_table=11
                     /translation="MRTPLRSTPAQQIVLAFLVLFASSPTLAAADERQAERLVEKGPAA
                     VDLGSVSLGDDLTLERLAPGVWRHVSWHEIEGFGRVPANGLLVVDGGEAALVDTAWTEE
                     QTGRLLDWAAEELGAKATLVVPGHFHGDCTGGLAAAHARGAESWAMAATAAKVAERGAP
                     VTHAAEEDHLSLDLGALKLEVHHLGAGHTPDNSVVWIPSRRVLFGGCLVRSAAAKDLGN
                     TADADLEAWPSTIEAVVARFPEVKVVVPGHGSPGGRELLDNTLALTRAAGAGGRPTRGM
                     GPN"
     CDS             complement(3117..3839)
                     /locus_tag="ctg281_4"
                     /transl_table=11
                     /translation="MISRALSWSRPERPIVLALLLAVVCFGPAQAQQGEGVDALVDRSI
                     EAYGGADRLHAVDGWQQIGKLVSPTRGEAVMARVFAPPERLRVEIRFSDESSETRILNG
                     EQGWRSGRAVQGPMHAAMVLQAARLSLPLILLEGRDRIRDLGEGEAQGRSVRRLSLGLR
                     NDMRLEVEIDEETARIVRSRSIAGPLVFETAYEDFREVDGILFPFVEKSWAMGQETGRY
                     EIERVALDGELGDQVFRP"
     CDS             4062..4733
                     /NRPS_PKS="Domain: oMT (39-142). E-value: 1.4e-12. Score:
                     38.1. Matches aSDomain: nrpspksdomains_ctg281_5_oMT.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 80.6; E-value:
                     2.1e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg281_5"
                     /transl_table=11
                     /translation="MTSYYSERLSGERLRRCYEIAPPRVRRYLRSEIDLVLDRLEAGAQ
                     VLELGCGYGRVLGELATKARVAVGVDLSLDSLCLARRELANGGRCRLASMNAAALAFSG
                     QQFDLVACVQNGVSAFRVDRRTLIREAARVTRPGGRLLFSSYTERFWAHRLEWFRRQSE
                     AGLIGRIDEHATGEGVIVCEDGFRATTVSAREMLSLCSGLGLVATAFEIDGSSLFCEVM
                     V"
     aSDomain        4179..4487
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg281_5_oMT.1"
                     /domain_subtype="oMT"
                     /evalue="1.40E-12"
                     /label="ctg281_5_oMT.1"
                     /locus_tag="ctg281_5"
                     /protein_end="142"
                     /protein_start="39"
                     /score="38.1"
                     /tool="antismash"
                     /translation="LEAGAQVLELGCGYGRVLGELATKARVAVGVDLSLDSLCLARREL
                     ANGGRCRLASMNAAALAFSGQQFDLVACVQNGVSAFRVDRRTLIREAARVTRPGGRLLF
                     "
     aSModule        4179..4487
                     /domains="nrpspksdomains_ctg281_5_oMT.1"
                     /incomplete
                     /locus_tags="ctg281_5"
                     /tool="antismash"
                     /type="unknown"
     CDS             complement(4987..5178)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg281_6"
                     /transl_table=11
                     /translation="MKKQITKKLSLSKETLRNLSERELAGVVGGISRTCCNSCTDWSDC
                     SCPTDGCTETCTDLSNCC"
     CDS_motif       complement(5113..5178)
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKQITKKLSLSKETLRNLSER"
                     /locus_tag="ctg281_6"
     CDS_motif       complement(4987..5112)
                     /score="-14.90"
                     /locus_tag="ctg281_6"
                     /leader_location="[5112:5178](-)"
                     /molecular_weight="4013.4"
                     /predicted_class="Class I"
                     /monoisotopic_mass="4010.6"
                     /tool="antismash"
                     /peptide="lanthipeptide"
                     /core_sequence="ELAGVVGGISRTCCNSCTDWSDCSCPTDGCTETCTDLSNCC"
                     /leader_sequence="MKKQITKKLSLSKETLRNLSER"
                     /alternative_weights="4031.4"
                     /alternative_weights="4049.4"
                     /prepeptide="core"
                     /aSTool="lanthipeptides"
     CDS             complement(5428..8823)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     726.8; E-value: 6.1e-220)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg281_7"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-172, bitscore:
                     564.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-64, bitscore:
                     207.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDDTYRLDEHYRQCGPVVLRTPLLPFDEIETWGDGLKSDDQPG
                     SGAGDGDDGGALEEALAHDRELLRGRLRQLLERPEIAEAVFLASPELVRSLGQWRRDPE
                     SKKGRRSEQGLVRYLLRMASRPTPFGLFAGCTPGSVAQDSEASRLALVPRSAYRRHSRL
                     DMDYLFALCEHLGRDAAVREAVRLRPNSSLYASGGRLRYAEARLAGRLRTYHLVAVEAF
                     EALELILERAADPAEGGARLGDLAAALVAADPDGEITLEEAREFLDEVVDNQILVPDLA
                     LEVTGEESTPGLLRQLAELGVEGEAEQRLERSRRALAAIDAGGVSAPTVGSPTDRYQEI
                     ATDLEPLGVPVEMSRLFQVDLVKPGAEVKLAPEVVDEILRGVGLLYRLGPAWRDSRIED
                     FSSAFRERYGEGREVPLLDALDEERGLGFERSNQAGAEASPLLSGLPMLPRGDRRTIPW
                     AEREALLLRRLSETLLAGEAEMVIGNADVEALDGVERPPLPDAFHTMVSLAASSPEGLA
                     EGDFRLLLAHAAGPSGARLLGRFCHTDEAIRTGVEEHLAAEEALAPDAVFAEIVHLPEG
                     RIGNILARPLLRRFEIPFLGHSGAPGGQQLPAQDLLITVSGERVRLRSKSLGREVIPRL
                     TNAHNTSRSSLGLYRFLAALQAQGRTGGVSWIWGPLEAAPFLPRVTSGRIVFACARWRV
                     SASEIRPLAKASGAKRWRLAQRWRHERHMPRLVALADGDNELLLDFRNPLSLDAVVEVI
                     KNREEAVLTEVFPGPDELCAEGPEGRFFHELVVPFVRRPKEPAEDAALARATAPAPSDG
                     PSGSVERTPLPRILPPGAGWLFAKLYSGTASADRMLRDEVAPLARWTIETGAAQSWFFM
                     RYGDPLWHLRVRFRGDPGRLREEVQPRLEEVFARLLDSGTAWKAQLDTYEREMERYGGE
                     AGMELSEELFFHDSEAVVALLEWCSGDAGADLRWRLALLGMDRLLADFGLDLEARLALA
                     EPARDGFARRYRYEELLRTPVADRLRQERASLQRLLAFDLETADEEYRPGLAILARRSH
                     AIAPIVQELQERDRRGELTTPLARIVPSYVHMFVNRLSRSAGPEHELVLYDFLVQLYRS
                     QIARERAQSRKKGERGGKRAAAKG"
     CDS             complement(8820..10106)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     300.8; E-value: 2.5e-91)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg281_8"
                     /sec_met_domain="LANC_like (E-value: 3e-56, bitscore:
                     180.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWRPIISGETHREAWTVIEEIERSLAERLASDPALSSNPTLAAGT
                     AGLALFYAYLDATRPGSDAGDRALECLGQSIDRLGRANIGPSLYSGFAGVGWTIEHLRG
                     DFFDGDDDLTDPIDGALEDLLESPGQEPYELIRGVAGYGMYLLERLPHPTATALLVRVI
                     DHLEATAERSEAGCAWFTPAAWQLERQREIMPDGCYNLGVAHGIPGVLGFLAAARRNGI
                     DDPRLEELAEGTVRWLLAQQIPEDRNSVFPAYFSPGSGPLPARTAWCYGDLGIAAVLLL
                     AARSFGRPRWEEEAVALAHGAAERSAQVAGVDDACLCHGYAGNAHLFVRLYRATGDPVL
                     REAALAWIDQALASRRPGEGVAGYSAWYAQADGSGAWMADPGFLMGAAGVGLALLAAAS
                     DVEPDWDRVMVVSVPPQTAAAAAEEGEAA"
     CDS             complement(10199..10390)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg281_9"
                     /transl_table=11
                     /translation="MKKQITKKLSLSKETLRNLSERELSGVVGGITATCCNSCSDWSDC
                     SCPTEGCTETCTDLSRCC"
     CDS_motif       complement(10325..10390)
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKQITKKLSLSKETLRNLSER"
                     /locus_tag="ctg281_9"
     CDS_motif       complement(10199..10324)
                     /score="-14.90"
                     /locus_tag="ctg281_9"
                     /leader_location="[10324:10390](-)"
                     /molecular_weight="3982.4"
                     /predicted_class="Class I"
                     /monoisotopic_mass="3979.6"
                     /tool="antismash"
                     /peptide="lanthipeptide"
                     /core_sequence="ELSGVVGGITATCCNSCSDWSDCSCPTEGCTETCTDLSRCC"
                     /leader_sequence="MKKQITKKLSLSKETLRNLSER"
                     /alternative_weights="4000.4"
                     /alternative_weights="4018.4"
                     /alternative_weights="4036.4"
                     /prepeptide="core"
                     /aSTool="lanthipeptides"
     CDS             complement(10478..11341)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 238.6; E-value:
                     2.3e-72)"
                     /gene_kind="transport"
                     /locus_tag="ctg281_10"
                     /transl_table=11
                     /translation="ETNLERLDDVLSTPAEPQGLDRPEPEELAGRVTLQDVTFRYGPLV
                     PPALDSVSLEAAPGQLVAVAGASGSGKSTLAGVVAGLLEPESGLVLYDGHPLDELPRDW
                     LRAQLAYVPQQSFLFGSSIRANIALPDPDLPMERIVEAARLAEIDDEIRALPMGYETVL
                     ADGGTSLSGGQRQRIALARALVGRPRVLILDEATSSLDAVTEHKVQQNLRRLEMTSIVA
                     AHRLSTIRDADRILVLANGRVVDSGTHDELVGRPGVYQRLARAQIEGQDRLRPDVDSDR
                     AGEVSR"
ORIGIN
        1 ggacgccgac tgcgccgcca tctcctgtaa ggccgacagc gactgtcctc cgaacgccac
       61 ctgcggcgcc aacggcactt gccagaacgt ctgccagaac accacctgcg cctgttcatc
      121 ggccgggccc gcctgcccgg gggccgggac gatgtgcaac ctcgccgcag acagcagctt
      181 cggcttctgc gccggcggcg cctgccagta caacggcctc gtccccgaga acggtgcggg
      241 gaccacctct ccccagtggg agctggcggc gacctgctcc tcggacgccc agtgcgcggc
      301 ggaacagacc tgcaacgatg gtcagtgcac gtgtgggtcg aacgacgact gcaccgcact
      361 gggtggcacc tgcagcggcg gcgtctgcgt cgggcagacg gccgtcgtct gcatgccgca
      421 gggctggggt gggcgggtct ggggacgcac cggctgcgcc aaggccggcg atgccttcca
      481 gtgccaaaca ggccagtgcg gtgccggtgc gtcggccgtc ctcgagtgca ccgacgtcgc
      541 ggccggcatc acgcagacgg ccaccggcgt caccctgttc gaggggacct gggacagcaa
      601 cggcgtcgac ttctgggatg tcagcctggt caacgggtac aacgttccgc tgcaggtggc
      661 cgcgttcgtc ggcggcaagg ccgcgccgtg caccttcgcg gggaccgact ttgtcggccg
      721 gcccgtaggc tgcgaaagtg acctcaacga tgcctgtccg acaccgctcc agatcgccgg
      781 caagtgcaac tgcgtcgccg acgccgactg tccccaaggg cagacgtgcg gcgccgacaa
      841 cctctgctcg ggcgccggcg gctgcaccgt cgtctgcatc gacccgggtg actactgcac
      901 gagcttcggc ctctacggca acaatccggt catcacgccg ccggccgctt tgaagtgcaa
      961 cgacccggtc tcgacgctca acgccaccac ctacaacgac tactactcct gcaccggctc
     1021 gctctccgag ctgagctgca acaacgcggc gatcacctgt ttcgccgaca acgactgccc
     1081 gttctatccc gaccaggtct gccaggcgaa cgtatgcatg ccggtgagcg tggaggacac
     1141 cctggcgcag tgcgtcagcg gtgcctgcaa ccccaaggtc aaccacgtcg accagtactc
     1201 ctgccagacg gtccaggaga tgtcgctctg cctgccgaag ccacccacct ccacggccca
     1261 gagcggctgt tgcggggcct acaaccccga ctggatgacc gccgcccagg ccgccaacgg
     1321 caccccgggc ggtgccacgt tcgccgaagc gttccggacc gcctgcccgc tctcctacgc
     1381 cttccagttc gacgacgtgg cgagcagctt ccagtgctcg aacgcctccg gggaagtgga
     1441 ctacctggtg acgttctgcc cggtcgccga gccggccaag acggagccgg cggcccccgc
     1501 ccagggcccg gccgagggtg gcagggtcat ggctctcccc tcggggaggc cctgatccct
     1561 cgggcaagct ggagcggtcg ggaacggtgc gaggcaaccc gtggtggcag ccgtctcccc
     1621 tcgggcgctc tccgcgtagc ggttgcggcc cttgagcttc tgcccacagt agggggcggg
     1681 gatgtcgccg caacagttgc ccgcgatgag gcagggcgtc cgatcacggg ttgtccggca
     1741 cttcctggac gattcgaccc tcgcggtcga tgaccgccca gcttcctccc tgaacggtgc
     1801 cgtgctcgtc cccgtcctcg cgcacgatgg agcagccggt gcacacccgg gcgaagccgc
     1861 cttcgaacgg gagggcgaag tcccactccc ggggcacgac gacctcgaga ccctcgttca
     1921 cgaacccgac cttgccgtca cggatggtgc gcgcgcggcc ctccacgaag tagtcgggtc
     1981 cgttgtcgaa gaggagggcc ggcgcggttc tcccagaggc cagggcgtaa tagaggtcgc
     2041 cctcgaccag cacagcatgg gggccgcctt cgtcgggcac gactcctgga cggagcacga
     2101 gctcaccctc cgcgtcacgg cggccacagt ccgccaccgc atccgcttcc cccggaaaga
     2161 ctgcacaggc aatcggccat tcgggagccg gctcggggga ctcgccggca caggcgagaa
     2221 cggcgagaag aggcagggcc gtggcaagaa gcttcatcag ttcggcccca tccctctcgt
     2281 cggcctaccg cccgctcccg ccgctcgggt gagggcgagg gtgttgtcga ggagctcgcg
     2341 tccgccgggg gaaccgtggc cggggacgac gaccttcacc tcggggaagc gggcgacgac
     2401 cgcctcgatg gtggacggcc aggcttcgag gtcggcgtcc gccgtgttgc cgaggtcctt
     2461 cgcggccgcc gagcgcacca ggcaaccgcc gaagagcacg cggcgcgacg ggatccagac
     2521 caccgagttg tccggcgtgt gccccgctcc gaggtggtgg acctccagct tcagcgctcc
     2581 caggtcgagg gagaggtgat cttcctccgc ggcatgggtc accggagcac cgcgctccgc
     2641 aaccttggca gcggtggcgg ccatcgccca cgactcggcg cccctggcgt gggccgccgc
     2701 caggccgccc gtgcagtccc cgtggaaatg gcccggcacg accagggtcg ccttggcgcc
     2761 gagctcctcg gccgcccagt cgagcaggcg gccggtctgc tcctcggtcc aggcggtgtc
     2821 gacgagggct gcctcgccgc cgtcgacgac caacagcccg ttcgccggca cccggccgaa
     2881 gccctcgatc tcgtgccacg agacatggcg ccacaccccg ggcgccaagc gttcgagggt
     2941 gaggtcgtca ccgaggctga cgctgccgag gtcgaccgcg gcggggccct tctcgacgag
     3001 tcgctccgcc tgccgctcgt cggccgctgc cagggtgggg ctcgatgcga acaggacgag
     3061 gaacgcgagg acgatctgct gtgcgggggt actcctcagg ggggtgcgca tcctgctcag
     3121 gggcgaaaca cctggtcgcc gagctcgcca tcgagggcga cccgttcgat ctcgtaccgg
     3181 cccgtctcct gccccatggc ccagctcttc tcgacgaacg ggaagaggat gccatcgacc
     3241 tcgcggaagt cctcgtaggc ggtttcgaag accaggggcc cggcaatgct gcgggagcgc
     3301 acgatcctcg cggtctcctc gtcgatctcg acctcgaggc gcatgtcgtt gcgaaggccg
     3361 aggctcagcc gcctgacgct tcggccttgc gcttcgccct ctccgagatc ccggatgcgg
     3421 tcccttccct cgaggaggat cagggggagg gacagccggg cggcctgcaa gaccatggcg
     3481 gcgtgcatcg gaccctggac ggctcggccg gatctccagc cctgctcgcc gttgaggatc
     3541 cgcgtctcgc tcgactcgtc cgagaaccga atctcgaccc ggagccgctc cggcggcgcg
     3601 aacacccgcg ccatcacagc ctccccccgg gtaggcgaga cgagcttgcc gatctgctgc
     3661 cagccgtcca cagcgtgcag acggtccgcg cccccgtagg cttcgatact acgatcgacc
     3721 agggcgtcca ccccctctcc ttgctgtgcc tgggcggggc cgaagcagac gacggcgagc
     3781 aggagagcga ggacgatcgg tcgctccgga cgggaccagc tcagcgctct agagatcatg
     3841 cgcggatctt acgcgatccg gcgatgggca acgcgcggcg ggggcggggc tgtcaagagg
     3901 ttcctggcac ttaggggaaa ggctgcggct ggggctcggg ccacgtggcg tagtggtctg
     3961 tccatgctct aggggacgga agatggtagg tgccatcgct cacggctgac cgcctcgggt
     4021 tgcgccacgg tttgtgtggc accatggcgg gacacgacgg catgaccagc tactactccg
     4081 aacggctctc cggcgagcgg ctccgccgct gctacgagat cgcgccgccg cgggttcggc
     4141 gctacctccg ctccgagatc gacctcgtcc tggatcggct ggaggccgga gcccaggtcc
     4201 tggagttggg gtgcgggtac gggagagtgc tgggtgagct ggccacgaaa gcgcgggtcg
     4261 cggtgggggt cgacctctcg ctggacagcc tgtgcctcgc ccgacgggag ctcgccaacg
     4321 ggggccgttg ccggctggca agcatgaacg ccgcggccct cgccttttcc ggacagcagt
     4381 tcgacctggt tgcctgtgtg cagaacggcg tttccgcgtt ccgggtcgac cggcggaccc
     4441 tcatccggga ggcggcgcgc gtgacccgcc ccggcgggcg cctcctgttc tcgagctaca
     4501 cggagcgctt ctgggctcac cgcctggagt ggttccgccg gcagtcggaa gcggggctca
     4561 tcgggaggat cgacgagcat gcgacaggcg agggcgtcat cgtctgcgag gacgggtttc
     4621 gggccacgac ggtgagcgcc cgggagatgc tctccctctg ctccggtctc ggtcttgtgg
     4681 cgacggcctt cgagatcgac ggctcgagcc tcttctgcga ggtcatggtc taaggctcgg
     4741 atcgaccgcc acggtttgtg tggcaccacg gttgggcacg gttgcggttg ggccggggcc
     4801 gccgtgtcgg cagcgagggc cgggttgctc aggagggatt ggtccgagac taggtgctcg
     4861 gccagggagc gctcgatctc ctcgatgatg gtccaggctc cgcggtgggg ctcgcggtgg
     4921 aggattgggg cccgaggggc acgccgcgcg gaccgcggcg tgcccccccg ggtccggtct
     4981 tctacctcag cagcagttcg agaggtccgt gcaggtctcc gtgcacccgt cggtgggaca
     5041 ggagcagtcg ctccagtcgg tgcaactgtt gcagcaggtc ctggagatac cgcccacgac
     5101 cccggcgagc tcgcgctcgg acaggttccg gagggtctcc ttgctgaggc tgagcttctt
     5161 cgtgatctgc ttcttcatgt cgatgtctcc tttcgactgc ggttatgcgg cactgcgcaa
     5221 gaagccaagc gccgcgggtg agctggagat ctggacagca gcaggctcaa cgggccacct
     5281 cgccggctcg gtcgctgtcg gcgccctgcc ccggccggtc ctggttctcg atctgccacc
     5341 acgatgtctc tggcacttcc tccccctcca gccacggttg ccacggttgg gtcacgcctt
     5401 cacgcgcggc cgtcgacgcc tcccccctca ccccttggca gcagcccgtt tcccgccgcg
     5461 ctcgcccttc ttccgtgact gcgcgcgctc gcgggcgatc tgggatcggt agagctggac
     5521 caagaagtcg tagagcacca gctcgtgctc ggggccggcg gagcggctca ggcggttgac
     5581 gaacatgtgg acgtagctgg gaacgatcct ggccaggggt gtcgtgagct cgccccgtcg
     5641 gtcgcgctcc tggagctcct ggacgatcgg ggcgatcgcg tgggagcgtc gggcgaggat
     5701 ggcgaggccg ggccggtact cctcgtccgc cgtctcgagg tcgaaggcga ggaggcgctg
     5761 gagggaggcc cgttcctggc gcagccggtc ggccaccggg gtgcgcagga gctcctcgta
     5821 gcggtagcgg cgggcaaacc cgtcccgcgc cggctcggcg agggccagcc gggcctcgag
     5881 gtcgagcccg aagtcggcca gcaggcggtc catgcccaga agtgccaggc gccaccgcag
     5941 gtccgcgccg gcgtccccgg agcaccactc gaggagggcg accacggctt cggagtcgtg
     6001 gaagaagagc tcttcggaga gctccatccc ggcctcgccg ccgtagcgct ccatctcccg
     6061 ttcgtaggtg tcgagctggg ccttccaggc ggtgccggag tcgagcaggc gggcgaagac
     6121 ttcctcgagc cggggctgga cctcttcgcg aagccgcccg gggtcgcccc ggaaacggac
     6181 tctgaggtgc cagagcgggt cgccgtagcg catgaagaac cagctctggg cggcgccggt
     6241 ctcgatcgtc cagcgtgcga gcggtgccac ctcgtcccgc agcatccggt cggcgctcgc
     6301 cgtccccgag tagagctttg cgaacagcca gccggcgccc ggcggcaaga tccggggcag
     6361 aggcgtccgc tcgacggagc ctgaaggccc gtcggaggga gcgggagccg tggccctcgc
     6421 gagggcggcg tcctcggccg gctccttcgg acgccggacg aacggcacca ccagctcatg
     6481 gaagaagcgg ccctcgggcc cctcggcgca gagctcgtcc ggcccgggga agacctcggt
     6541 gagcacggcc tcctcgcggt tcttgatcac ctcgacgacg gcgtcgaggc tcaaggggtt
     6601 gcggaagtcg aggagcagct cgttgtcgcc gtcggccagg gccacgagcc gcggcatgtg
     6661 gcgctcgtgg cgccagcgtt gcgccaggcg ccagcgcttc gccccggagg ctttggccag
     6721 cggccggatc tcgctcgccg agacccgcca gcgggcgcag gcgaagacga ttcgtccact
     6781 cgtcacccgc ggcaggaagg gggctgcctc gagcggtccc cagatccagg agacgccgcc
     6841 ggtccggccc tgggcctgga gcgcggcgag gaaacggtag aggcccaggc tcgagcggct
     6901 ggtgttgtgg gcgttggtca gccgggggat cacttcgcgc ccgaggctct tcgaacgcag
     6961 gcggacccgt tcgccgctca ccgtgatcag tagatcctgg gcggggagct gctgccctcc
     7021 cggggcgccg gagtggccga ggaagggaat ctcgaagcgc cgcaggaggg ggcgggcgag
     7081 gatgttgccg atcctgcctt cgggcaggtg cacgatctcg gcgaagacgg cgtcgggggc
     7141 gagagcctcc tccgccgcca ggtgctcctc gacgcccgtg cggatcgcct cgtcggtgtg
     7201 gcagaagcgc cccagcaggc gggctccgga gggccccgcc gcgtgcgcca gcagcagccg
     7261 gaagtcgccc tcggcgagcc cctcggggga ggaggcggcg aggctgacca tggtgtggaa
     7321 ggcgtccggg aggggtggcc gctcgacccc gtcgagggcc tccacgtctg cattgccgat
     7381 caccatctcg gcctccccgg cgagcagggt ctcggagagt cgcctgagga gcagggcctc
     7441 gcgctcggcc cacgggatgg tgcgccggtc gccccggggc agcatcggca ggcccgagag
     7501 cagaggcgac gcctcggcgc ccgcctggtt cgagcgctcg aagccgaggc cgcgctcctc
     7561 gtccagggcg tcgagcaggg gcacctcgcg cccttcgccg tagcgctccc ggaaggcgga
     7621 tgagaagtct tcgatccgcg agtctcgcca cgccggaccg agccggtaga ggaggccgac
     7681 gccgcggagg atctcgtcga ccacctccgg tgccagcttc acttccgccc ccggcttgac
     7741 gaggtccacc tggaacagcc gggacatctc gaccggtacc cccaggggct cgaggtcggt
     7801 ggcgatctcc tggtacctgt cggtggggga gcccaccgtg ggggcgctga cgcccccggc
     7861 gtcgatcgcg gcgagggcgc gcctcgagcg ctccaggcgc tgttcggcct cgccctccac
     7921 cccgagctcg gcgagctgcc ggaggagccc gggggtgctc tcctcgcccg tgacctcgag
     7981 tgccaggtcg gggaccagga tctggttgtc gaccacctcg tcgaggaact ccctggcctc
     8041 ctcgagggtg atctcgccgt cggggtcggc ggcgaccagg gcggcggcga ggtcgccgag
     8101 gcgggcgccc ccttctgccg ggtccgccgc gcgttcgagg atgagctcga gggcttcgaa
     8161 cgcctcgacc gcgaccaggt gataggtccg caagcgcccc gccagccggg cctcggcgta
     8221 gcggagccgc ccaccggagg catagaggct cgagttcggg cgcagccgga cggcctcgcg
     8281 gaccgccgcg tcgcggccca ggtgctcgca cagagcgaag aggtagtcca tgtccagccg
     8341 gctgtggcgc cggtaggcgc tccgcggcac cagcgccagg cgcgaggctt cggagtcctg
     8401 ggcgacggac cccggcgtgc agccggcgaa gagcccgaac ggggtgggtc gcgacgccat
     8461 gcggaggagg tagcgcacca gcccctgctc gctccgccgg cccttcttgc tctccgggtc
     8521 ccgccgccac tgtccgaggc tgcgcaccag ctccggcgag gcgagaaaga ccgcctccgc
     8581 gatctccggc cgctcgagga gctgccggag gcggccgcgg agcagctccc ggtcgtgggc
     8641 cagggcctcc tcgagagccc ccccgtcgtc gccgtcgccg gctccggagc ccggctgatc
     8701 atcgctcttc agcccgtcgc cccaggtctc gatctcgtcg aatggcagga gcggcgtccg
     8761 caggacgacc gggccgcact gccggtagtg ctcgtcgagg cggtaggtgt cgtcgaggct
     8821 catgccgctt cgccctcctc cgcggcggcc gcggcggtct gcggcggcac cgagaccacc
     8881 atcacgcggt cccagtccgg ttcgacgtcg ctcgccgccg ccagcagggc caggccgacc
     8941 cccgcggctc ccatcaggaa gccggggtcc gccatccacg ccccgcttcc gtccgcctgg
     9001 gcgtaccagg ccgagtagcc ggcgaccccc tcgcccggcc ggcgggacgc gagggcctgg
     9061 tcgatccagg cgagggcggc ctcgcgcagc accgggtcac cggtcgcccg gtagaggcgg
     9121 acgaagaggt gtgcgttgcc cgcatagccg tggcacaggc aggcgtcgtc cacgcccgcc
     9181 acctgtgccg agcgctccgc cgcgccgtgg gcgagggcga cggcctcctc ttcccaccgg
     9241 gggcgtccga agctccgggc cgcgagcagg agcaccgcgg cgatcccgag gtcgccgtag
     9301 caccaggcgg tgcgcgccgg gagcggtccg ctgcccgggg agaagtaggc cgggaagacc
     9361 gagttgcggt cctccgggat ctgctgggcg aggagccacc ggacggttcc ctcggcgagt
     9421 tcctcgagcc gggggtcgtc gatcccgttg cgccgggccg ccgccaggaa gccgagcacg
     9481 ccggggatgc cgtgagcgac ccccaggttg tagcagccgt cgggcatgat ctctcgctgt
     9541 cgctcgagct gccaggcggc gggcgtgaac caggcgcagc ccgcctccga gcgctcggcg
     9601 gtcgcctcca ggtggtcgat cacccgcacc aggagggcgg tggcggtcgg gtgcggcagc
     9661 cgttcgagca ggtacatgcc gtacccggcg acgccgcgga tcagctcgta cggctcctgc
     9721 ccggggcttt cgaggagatc ctccagcgcg ccgtcgatcg ggtccgtcag gtcgtcgtcg
     9781 ccgtcgaaga agtcacccct caggtgctcg atcgtccagc cgactccggc aaacccgctg
     9841 tagagcgacg ggccgatgtt ggctcttccg aggcgatcga tcgattggcc gaggcattcg
     9901 agcgcccggt ccccggcgtc cgagccgggg cgcgtggcgt cgaggtaggc gtagaagagc
     9961 gccagccccg cggtgccggc ggcgagggtc gggttgctcg agagggcggg gtccgaggcc
    10021 aggcgctcgg ccagggaccg ctcgatctct tcgatgacgg tccaggcttc gcggtgggtc
    10081 tcgccggaga tgatgggtcg ccacatgatg caagctcagg gagggtcgag gggttgagga
    10141 gggctcgagg ggcacgccac gcggaccgcc gcgtgcccct cgggtccggt cttctacctc
    10201 agcagcagcg cgagaggtcc gtgcaggtct ccgtgcaccc ttcggtggga caggagcagt
    10261 cactccagtc ggagcaactg ttgcagcagg tcgcggtgat gccgcccacg accccggaga
    10321 gctcgcgctc ggacaggttg cggagggtct ccttgctgag gctgagcttc ttcgtgatct
    10381 gcttcttcat gtcagttctc ctttcgactg cggtgatgcg gcgcgacgcc ggagggcgaa
    10441 gcgccgcgag ggagttggcg acctggacga gcagggctca acgggaaacc tcgccggctc
    10501 ggtcgctgtc gacgtccggc ctgagccggt cttggccttc gatctgggcg cgggccagcc
    10561 gctggtagac cccgggccga ccgacgagct cgtcgtgggt gccggaatcg accacacggc
    10621 cgttcgcgag caccaggatc cggtcggcgt cgcggatcgt gctcaggcgg tgcgccgcga
    10681 cgatcgaggt catctccagg cggcggaggt tctgctgcac cttgtgctcg gtcacggcgt
    10741 cgagggagct cgtggcctcg tcgaggatca gcacgcgggg gcggccgacc agggcgcggg
    10801 cgagggcgat ccgctggcgc tggcctccgg agagcgaggt tccgccgtcg gcaaggaccg
    10861 tttcgtaccc catgggcagg gcgcggatct cgtcgtcgat ctcggccagg cgcgcggcct
    10921 cgacgatccg ctccatgggt agatcggggt ccgggagtgc gatgttggcc cggatgctcg
    10981 agccgaagag gaaggactgc tgcggcacat aggcgagctg ggctcggagc cagtcccgcg
    11041 gcagctcgtc gagcgggtgg ccgtcgtaga ggacgagtcc ggactccggc tcgaggaggc
    11101 cggccacgac gccggcgagg gtcgatttgc cggatcccga agccccggcg acggccacga
    11161 gctgcccggg agccgcctcc aacgagacgg agtcgagggc gggcggaacc agcggaccgt
    11221 agcggaaggt gacgtcctgg agtgtgaccc ggcccgcgag ctcctccggc tccggccggt
    11281 ccaggccctg cggctcggcg ggggtcgaga ggacgtcgtc caggcgctcc aggttggtct
    11341 cc
//
