LOCUS       c00356_3300025..        3439 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300025855.a:Ga0209717_1023993.
ACCESSION   c00356_3300025..
VERSION     c00356_3300025..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 12:19:48
            Original ID  :: 3300025855.a:Ga0209717_1023993
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3439
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..2949
                     /NRPS_PKS="Domain: Condensation_DCL (1-245). E-value:
                     2e-74. Score: 242.1. Matches aSDomain:
                     nrpspksdomains_ctg356_1_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (406-784). E-value: 1.5e-89.
                     Score: 292.2. Matches aSDomain:
                     nrpspksdomains_ctg356_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (885-954). E-value: 4.5e-25. Score:
                     79.4. Matches aSDomain: nrpspksdomains_ctg356_1_PCP.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     316.3; E-value: 4.8e-96)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg356_1"
                     /sec_met_domain="Condensation (E-value: 3.2e-54, bitscore:
                     171.1, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.9e-97, bitscore:
                     313.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.7e-17, bitscore:
                     51.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AVDRHEILRTAFLHEKTRRPVQVVLKRRPIPVVFESVPDGEPPDR
                     YIARRKEEERAVGYDLGTDPLMRINVIACAPDRHTVIWNLHHIMLDGWGLSVLQQEFAH
                     IYATGGVAGLSPTVPYARYIEWIGRQDAVAARAYWSSRLAGFDTPTPAPARRHHKGTGY
                     DLQTIASALPADIVTKAGNVAAQLRITLGTFLQTVWGLMLANFHHASDVVFGTVVSGRP
                     ASLPGSDRMLGLFINAVPVRLDLTGSFVDAATRLQANVLEAEPHQHLFLGEVQNLSPLN
                     GRLIDHLFVFENYPVTTSSNTPFAGLTLKHAGSHERTNYDFAVVAAPTRENGVSLAFHY
                     NADVFDRSDIAGLADRFVTAFASAATTPTAGCEALDILPAEHRDIISTSIIGEAITIPD
                     RTVIDLIRDRAKYSPDAPAIRDDEGTLTYAALMAEADRMSRRLVAAGVGPGEPVAVLLP
                     RSRGLVAAALGVMGAGACYMPLDPAWPQERTAGIIRESRCRVAITDGSVPGGVTVLDRS
                     GDAPDAVFSPPAPDDDAYVIHTSGSTGHPKGVVIGHWALLNLALWHDRFYGLGPATVTT
                     LFSAPSFDASLWEMIPALVAGGSLVPVPDGIRADAGSMADFLRTRGVTHAFIPPVLTEG
                     ILREHEDRLPEGLTIHTGGELLRFAGTGRICVANNYGPSECCVAATAARLDTDELRRQI
                     PIGRPIDNVRISLLDRGGRPVPPGGTGEIVIGGACVGNGYLNRPDLTAERFADDPCIPG
                     GRIYRTGDLGRLDTDGNLLFAGRLDEQIQVRGYRVEPMEIERCLLEQPGVSSCAVAPAG
                     DLLTAFYVAGETIGESLLRDGLARLLPDYMIPARFVRVEAIPTAASGKIDRKALARLAP
                     ATPEEAYEPPVGACETAIAAAWSAVLGRERIGRRDSFFTLGGHSLKATQVATRLRKELG
                     REVDPSLLLRHPTIAGLAAALDEQRGETGPAIRRAARVARPASGSAQPGRQD"
     protocluster    1..3439
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:3438]"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..3438
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..3439
                     /SMILES="NC(CC(C)C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..3439
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     aSDomain        4..735
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg356_1_Condensation_DCL.1"
                     /domain_subtype="Condensation_DCL"
                     /evalue="2.00E-74"
                     /label="ctg356_1_Condensation_DCL.1"
                     /locus_tag="ctg356_1"
                     /protein_end="245"
                     /protein_start="1"
                     /score="242.1"
                     /tool="antismash"
                     /translation="VDRHEILRTAFLHEKTRRPVQVVLKRRPIPVVFESVPDGEPPDRY
                     IARRKEEERAVGYDLGTDPLMRINVIACAPDRHTVIWNLHHIMLDGWGLSVLQQEFAHI
                     YATGGVAGLSPTVPYARYIEWIGRQDAVAARAYWSSRLAGFDTPTPAPARRHHKGTGYD
                     LQTIASALPADIVTKAGNVAAQLRITLGTFLQTVWGLMLANFHHASDVVFGTVVSGRPA
                     SLPGSDRMLGLFINAVPVRLDLT"
     aSModule        4..2862
                     /complete
                     /domains="nrpspksdomains_ctg356_1_Condensation_DCL.1"
                     /domains="nrpspksdomains_ctg356_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg356_1_PCP.1"
                     /locus_tags="ctg356_1"
                     /monomer_pairings="leu -> leu"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       253..318
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_1_0001"
                     /evalue="9.30E-09"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg356_1"
                     /protein_end="106"
                     /protein_start="84"
                     /score="27.8"
                     /tool="antismash"
                     /translation="LHHIMLDGWGLSVLQQEFAHIYA"
     CDS_motif       631..726
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_1_0002"
                     /evalue="2.60E-18"
                     /label="C5_DCL_263-294"
                     /locus_tag="ctg356_1"
                     /protein_end="242"
                     /protein_start="210"
                     /score="58.4"
                     /tool="antismash"
                     /translation="DVVFGTVVSGRPASLPGSDRMLGLFINAVPVRL"
     CDS_motif       769..885
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_1_0003"
                     /evalue="1.00E-13"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="ctg356_1"
                     /protein_end="295"
                     /protein_start="256"
                     /score="43.6"
                     /tool="antismash"
                     /translation="QANVLEAEPHQHLFLGEVQNLSPLNGRLIDHLFVFENYPV"
     aSDomain        1219..2352
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg356_1_AMP-binding.1"
                     /evalue="1.50E-89"
                     /label="ctg356_1_AMP-binding.1"
                     /locus_tag="ctg356_1"
                     /protein_end="784"
                     /protein_start="406"
                     /score="292.2"
                     /specificity="consensus: leu"
                     /tool="antismash"
                     /translation="RDRAKYSPDAPAIRDDEGTLTYAALMAEADRMSRRLVAAGVGPGE
                     PVAVLLPRSRGLVAAALGVMGAGACYMPLDPAWPQERTAGIIRESRCRVAITDGSVPGG
                     VTVLDRSGDAPDAVFSPPAPDDDAYVIHTSGSTGHPKGVVIGHWALLNLALWHDRFYGL
                     GPATVTTLFSAPSFDASLWEMIPALVAGGSLVPVPDGIRADAGSMADFLRTRGVTHAFI
                     PPVLTEGILREHEDRLPEGLTIHTGGELLRFAGTGRICVANNYGPSECCVAATAARLDT
                     DELRRQIPIGRPIDNVRISLLDRGGRPVPPGGTGEIVIGGACVGNGYLNRPDLTAERFA
                     DDPCIPGGRIYRTGDLGRLDTDGNLLFAGRLDEQIQVRG"
     CDS_motif       1402..1443
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_1_0004"
                     /evalue="2.90E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg356_1"
                     /protein_end="481"
                     /protein_start="467"
                     /score="11.2"
                     /tool="antismash"
                     /translation="LGVMGAGACYMPLDP"
     CDS_motif       1600..1659
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_1_0005"
                     /evalue="1.10E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg356_1"
                     /protein_end="553"
                     /protein_start="533"
                     /score="27.2"
                     /tool="antismash"
                     /translation="AYVIHTSGSTGHPKGVVIGHW"
     CDS_motif       2008..2037
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_1_0006"
                     /evalue="2.20E-03"
                     /label="NRPS-A_a5"
                     /locus_tag="ctg356_1"
                     /protein_end="679"
                     /protein_start="669"
                     /score="10.6"
                     /tool="antismash"
                     /translation="NYGPSECCVAA"
     CDS_motif       2146..2235
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_1_0007"
                     /evalue="5.60E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg356_1"
                     /protein_end="745"
                     /protein_start="715"
                     /score="47.4"
                     /tool="antismash"
                     /translation="PPGGTGEIVIGGACVGNGYLNRPDLTAERFA"
     CDS_motif       2317..2382
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_1_0008"
                     /evalue="4.80E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg356_1"
                     /protein_end="794"
                     /protein_start="772"
                     /score="28.5"
                     /tool="antismash"
                     /translation="FAGRLDEQIQVRGYRVEPMEIER"
     aSDomain        2656..2862
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg356_1_PCP.1"
                     /evalue="4.50E-25"
                     /label="ctg356_1_PCP.1"
                     /locus_tag="ctg356_1"
                     /protein_end="954"
                     /protein_start="885"
                     /score="79.4"
                     /tool="antismash"
                     /translation="ETAIAAAWSAVLGRERIGRRDSFFTLGGHSLKATQVATRLRKELG
                     REVDPSLLLRHPTIAGLAAALDEQR"
     CDS             2959..3438
                     /NRPS_PKS="Domain: Condensation_LCL (8-159). E-value:
                     1.4e-50. Score: 163.7. Matches aSDomain:
                     nrpspksdomains_ctg356_2_Condensation_LCL.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     179; E-value: 3.1e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg356_2"
                     /sec_met_domain="Condensation (E-value: 2.4e-38, bitscore:
                     119.0, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNTEEYVFPMSYAQRRLWFLDQLEPGSSVYTIPKALRLTGPVDT
                     AALGAALAAIVDRHESLRTTFRDIDGTPSQVVSSVGYAPLKVTDLSTGSDPEGTARAMA
                     VKEASAPFDLAVGPLFRAHLLILGGDTSILVVTMSHIVSDGWSMGVLISEAAALYP"
     aSDomain        2983..3435
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg356_2_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.40E-50"
                     /label="ctg356_2_Condensation_LCL.1"
                     /locus_tag="ctg356_2"
                     /protein_end="159"
                     /protein_start="8"
                     /score="163.7"
                     /tool="antismash"
                     /translation="FPMSYAQRRLWFLDQLEPGSSVYTIPKALRLTGPVDTAALGAALA
                     AIVDRHESLRTTFRDIDGTPSQVVSSVGYAPLKVTDLSTGSDPEGTARAMAVKEASAPF
                     DLAVGPLFRAHLLILGGDTSILVVTMSHIVSDGWSMGVLISEAAALYP"
     aSModule        2983..3435
                     /domains="nrpspksdomains_ctg356_2_Condensation_LCL.1"
                     /incomplete
                     /locus_tags="ctg356_2"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2992..3024
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_2_0001"
                     /evalue="3.30E-04"
                     /label="C1_LCL_004-017"
                     /locus_tag="ctg356_2"
                     /protein_end="22"
                     /protein_start="11"
                     /score="12.8"
                     /tool="antismash"
                     /translation="SYAQRRLWFLDQ"
     CDS_motif       3046..3159
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_2_0002"
                     /evalue="1.80E-19"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg356_2"
                     /protein_end="67"
                     /protein_start="29"
                     /score="62.2"
                     /tool="antismash"
                     /translation="VYTIPKALRLTGPVDTAALGAALAAIVDRHESLRTTFRD"
     CDS_motif       3376..3435
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg356_2_0003"
                     /evalue="1.50E-10"
                     /label="C3_DCL_135-156"
                     /locus_tag="ctg356_2"
                     /protein_end="159"
                     /protein_start="139"
                     /score="33.5"
                     /tool="antismash"
                     /translation="HIVSDGWSMGVLISEAAALYP"
ORIGIN
        1 gctgtcgatc gccacgagat ccttcggacg gcattcctgc acgagaagac ccgaaggccg
       61 gtccaggtgg tgttgaaacg ccgcccgatc ccggtggtct tcgagtccgt gcccgacggc
      121 gaacccccgg atcgctacat cgcccgccgc aaagaggaag agcgggctgt cggctatgac
      181 ctgggaaccg atcccctgat gcggatcaac gtcatcgcct gcgcccccga ccgtcacacc
      241 gtgatctgga acctgcatca catcatgctg gacgggtggg ggttgtcggt ccttcagcag
      301 gagtttgccc acatctacgc gacgggcggc gtcgccggat tgtcccccac cgtcccatac
      361 gctcggtaca tcgagtggat cggcaggcag gatgccgtcg ccgcccgcgc ctactggagc
      421 agccgcctcg ccggattcga cacacccaca ccggcacccg cacgccgtca tcacaagggc
      481 accggctacg accttcagac gattgcctca gccctcccgg ccgacatcgt cacgaaagcc
      541 gggaacgtcg ccgcgcagct ccggatcacc ctgggcacct tcctgcagac ggtctggggg
      601 ctgatgctgg ccaatttcca tcatgcctcc gacgtcgtct tcggaacggt cgtctcgggc
      661 cgcccggcct cgctgccggg atctgaccgg atgctgggac tcttcatcaa tgccgtcccg
      721 gtgcggctcg acctgacggg ctcgttcgtc gatgcagcga cccggctgca ggccaacgtg
      781 ctcgaggccg aaccccacca gcatctcttc ctcggcgaag tccagaacct ttctcccctg
      841 aacggccggc tgatcgacca tctgttcgtc ttcgagaatt acccggtgac cacgtcgtcg
      901 aacactccct tcgccgggct gaccctgaaa cacgccggaa gccacgaacg aaccaactat
      961 gacttcgccg tcgtcgcggc gccgacccgc gagaacggag tatcgctcgc ctttcactac
     1021 aacgccgacg ttttcgaccg aagcgacatc gccggcctgg ccgaccgctt cgtcaccgca
     1081 ttcgcctcgg ccgccacgac gccgacggcc ggctgcgaag ccctggacat cctgccggcc
     1141 gaacatcgag atataatatc tactagtatt ataggtgaag caataaccat tcctgatcgc
     1201 accgtcatcg acctcatccg tgaccgcgcg aaatacagcc ccgatgcccc ggccatccgg
     1261 gacgacgagg gaaccctgac ctatgccgcc ctgatggccg aagccgaccg gatgagccgc
     1321 cgcctcgtcg ccgccggagt cgggccgggc gagccggtgg cggttctcct gccccgctcg
     1381 cgcgggctgg tagcggccgc cctgggagtc atgggcgcgg gagcctgcta catgccgctc
     1441 gatccggcgt ggccgcagga gcggaccgcc ggcatcatcc gggaaagccg gtgccgcgta
     1501 gccatcacag atggaagcgt ccccggcggc gtcaccgtgc tggaccgctc cggcgacgcg
     1561 cccgacgccg tcttttcgcc gccggcaccc gatgatgacg cctatgtcat ccacacctcc
     1621 ggctccacgg gccatcccaa gggggtggtc atcggccatt gggcgctgct caacctggcc
     1681 ctctggcacg atcgattcta cgggctcggc cccgcgacgg tcacgaccct gttctccgcc
     1741 ccctcgttcg atgcctcgct ctgggagatg atcccggccc tggtggcagg cggaagcctc
     1801 gtgccggttc ccgacgggat ccgggccgac gccgggagca tggccgactt cctccggaca
     1861 cgcggggtga cccatgcgtt cattcccccg gtgctgaccg agggcatcct gcgagagcac
     1921 gaagaccggc tgcccgaggg cctgacgatc cataccggcg gggagctcct ccgcttcgcc
     1981 ggcaccggcc ggatctgcgt cgccaacaac tacggcccga gcgaatgctg cgttgcagcc
     2041 acggcggccc ggctcgacac cgacgaactt cgtcggcaga ttcccatcgg ccgtccgatc
     2101 gacaacgtca gaatctccct gctcgaccgc ggcggccggc cggttccgcc cgggggaacc
     2161 ggagagatcg tcatcggcgg cgcctgcgtg ggcaacggct acctgaaccg ccccgacctg
     2221 acggccgaac gcttcgccga tgacccctgc attccaggag ggcggatcta ccgcaccggc
     2281 gacctcgggc ggctcgacac cgacggaaac ctcctgttcg cgggccggct cgatgagcag
     2341 atccaggtgc gcggttaccg cgtcgaaccg atggagatcg agcggtgcct gctggaacag
     2401 cccggcgtga gctcctgcgc cgtcgccccg gccggcgatc tcctcacggc gttctacgtg
     2461 gccggcgaaa cgatcggcga gtcgcttctt cgcgacggcc tcgcacggct gcttcccgac
     2521 tacatgattc cggcccgctt cgtccgggtc gaggcgattc cgaccgccgc cagcggcaag
     2581 atcgaccgca aagccctggc acggctggcg cccgcgactc cggaggaagc gtatgaaccg
     2641 ccggtcgggg catgcgaaac ggccatcgcg gcagcgtggt ctgccgtgct gggccgggag
     2701 cggatcggac ggcgggacag tttcttcaca ctgggcggcc attccctcaa ggccacgcag
     2761 gtcgctacac ggctcaggaa agaactgggc agagaggtcg atccgtcgct gctgctgcgc
     2821 catccgacga tcgccgggct ggcggcggcc ctcgacgaac agcgcggcga aaccggcccc
     2881 gccatccggc gggccgcccg cgtcgcccgc ccggcgtccg gctccgcaca acctggccgg
     2941 caggactgag aacgagagat gaacaatacg gaagaatatg tttttccgat gtcgtatgcc
     3001 cagcggcggc tctggtttct cgaccagctc gaaccgggct catcggtcta cacgatcccc
     3061 aaagccctgc gcctgaccgg cccggtcgac actgctgccc tcggtgccgc cctggccgcg
     3121 atcgtcgatc gccacgagtc gctccgcacg acgttcaggg acatcgacgg gacgccctcc
     3181 caagtagtct cctccgtcgg gtatgccccg ctgaaagtga cggatctctc gaccggttcc
     3241 gacccggaag ggacggcgcg ggccatggcc gtcaaagagg cttcggcccc gttcgacctc
     3301 gcggtcggcc cgctgttccg ggcgcatctg ctgatcctcg gcggcgacac atcgatcctt
     3361 gtggtcacca tgagccacat cgtatccgac ggctggtcga tgggggtgct gatcagcgaa
     3421 gcagccgccc tgtatccgg
//
