LOCUS       c00167_3300027..        7275 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300027965.a:Ga0209062_1010169.
ACCESSION   c00167_3300027..
VERSION     c00167_3300027..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 03:16:34
            Original ID  :: 3300027965.a:Ga0209062_1010169
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7275
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7275
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3950](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3..3950
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..7275
                     /SMILES="NC(Cc1ccc(O)cc1)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7275
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             3..3950
                     /NRPS_PKS="Domain: AMP-binding (271-660). E-value:
                     1.1e-104. Score: 341.9. Matches aSDomain:
                     nrpspksdomains_ctg167_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (767-831). E-value: 1.9e-20. Score:
                     64.6. Matches aSDomain: nrpspksdomains_ctg167_1_PCP.1"
                     /NRPS_PKS="Domain: Epimerization (844-1147). E-value:
                     6.6e-117. Score: 382.9. Matches aSDomain:
                     nrpspksdomains_ctg167_1_Epimerization.1"
                     /NRPS_PKS="Domain: TIGR01720 (1154-1310). E-value: 4.5e-41.
                     Score: 132.0. Matches aSDomain:
                     nrpspksdomains_ctg167_1_TIGR01720.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     358.6; E-value: 7.4e-109)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg167_1"
                     /sec_met_domain="Condensation (E-value: 7.8e-66, bitscore:
                     209.2, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-115, bitscore:
                     373.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.3e-17, bitscore:
                     49.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="QQLAGISEPNPISWKPVEKIERQDTTDYGAVELRLSDEEFANVLQ
                     MAQNHRLTLNTLAQGAWALLLQKYGAGEDVLFGVTVSGRPPEISGVEDMVGLFINTLPM
                     RISLSPNTVVTSWLEDIQQRQAQMREYEYSKLTDIRQAIAFPAAESLFESILVFENYPV
                     DQSLKNQGQGIQVDDIQFYERTNYPLTVAFIPHSGLLLKLNYETKFLSPHAAEIMLQRL
                     RNLLLQLAQNPNAPLGNIALLSTEEHNLTVNEWNANSIDWGDFRAAHQLFEDQADLDKD
                     AIALVLGEDSITYGELEQKANTLAATLKSAGVNDGSLVGLYFEPSIDFVVALLAVLKAG
                     GAFVPLDTTYPEERLKFILEDSQANFILAKEVVPFKHNYEHSKVIALSEIEWTHHPKRL
                     NLNINALHLAYVIYTSGSTGKPKGVLVTHAGIQNLVQTQTATFGVTNQSRVYQFASLNF
                     DAAISEIFMALGSGATLYLTSKADRFPGPALWEALTAWKISHLTLVPSVLATIKPEELP
                     ELQTLIVAGEAASGNLLHRWGDKERQVFNAYGPTEATVCASMMDCSHLVGEPSIGRGMA
                     NTELYLLDPYFQPVPPGIPGEICIGGIGLARGYLNRPGLTASAFIPHPFAKEPGARLYR
                     TGDIGVYDAQGHIYFLGRQDNRVKLHGYRIELGEIEAALAEHAVVESAVVMLREDVPGH
                     PRLVAYVLTPSEEITSQELLNDLSAVLPAYMVPSAVVFVKEWSLTPNGKIDRKALPAPE
                     MPTGQFSTIATNETEKILCQIWTEVLGIEANVNHNFFEIGGDSIMSLQIVSRAREAGLD
                     ISPRDIFEAQTLGRLAAIAKPLRQSITVDEALTGKVPLAPIQHWFFERNLPHSHQWNQT
                     VALSVSEPLKMDAFFMALEAIVAHHDAFRLEFDQNQGIWEQSYTAAASPPLRIKDFSTY
                     PPNEQRHALDAVVAEEQELIDLKSPPLLRVLYAKNLEEYGDVLIFFGHHLIVDGVSWRI
                     IFEDLNQAYCQAAMGKPVSLPARSSSYRQWTTSLEKLASSPEIVQDLSFWQETLAHKSA
                     ALPLDSLAPESNTVASLVVETSQLSSRETLSLLKEAIATYHAGVQEILLAALLKTLTDW
                     SDSSHVLIDLEGHGREDLGSGLDISRTVGWFTSLYPVLLQKPQENENLENLLKEVKKQI
                     RAIPNHGISFGLLRYLNQNPDTRETLTHLDKPQISFNYLGQVDNQQNSNNIFSLSNVPT
                     GSGMFAKQERPHILAINARVQGECLWVDWSYSKHLHNAQTIRHLAESYLHNLRAYLTNS
                     IQYQASFYTTSDFRLVELTDNELDSLLEDLG"
     CDS_motif       222..317
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0001"
                     /evalue="8.60E-21"
                     /label="C5_DCL_263-294"
                     /locus_tag="ctg167_1"
                     /protein_end="105"
                     /protein_start="73"
                     /score="66.4"
                     /tool="antismash"
                     /translation="DVLFGVTVSGRPPEISGVEDMVGLFINTLPMRI"
     CDS_motif       366..488
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0002"
                     /evalue="1.80E-14"
                     /label="C67_DCL_14fromHMM"
                     /locus_tag="ctg167_1"
                     /protein_end="162"
                     /protein_start="121"
                     /score="46.1"
                     /tool="antismash"
                     /translation="QQRQAQMREYEYSKLTDIRQAIAFPAAESLFESILVFENYPV"
     CDS_motif       492..539
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0003"
                     /evalue="5.70E+01"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg167_1"
                     /protein_end="179"
                     /protein_start="163"
                     /score="-2.8"
                     /tool="antismash"
                     /translation="DQSLKNQGQGIQVDDIQ"
     aSDomain        816..1982
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg167_1_AMP-binding.1"
                     /evalue="1.10E-104"
                     /label="ctg167_1_AMP-binding.1"
                     /locus_tag="ctg167_1"
                     /protein_end="660"
                     /protein_start="271"
                     /score="341.9"
                     /specificity="consensus: tyr"
                     /tool="antismash"
                     /translation="FEDQADLDKDAIALVLGEDSITYGELEQKANTLAATLKSAGVNDG
                     SLVGLYFEPSIDFVVALLAVLKAGGAFVPLDTTYPEERLKFILEDSQANFILAKEVVPF
                     KHNYEHSKVIALSEIEWTHHPKRLNLNINALHLAYVIYTSGSTGKPKGVLVTHAGIQNL
                     VQTQTATFGVTNQSRVYQFASLNFDAAISEIFMALGSGATLYLTSKADRFPGPALWEAL
                     TAWKISHLTLVPSVLATIKPEELPELQTLIVAGEAASGNLLHRWGDKERQVFNAYGPTE
                     ATVCASMMDCSHLVGEPSIGRGMANTELYLLDPYFQPVPPGIPGEICIGGIGLARGYLN
                     RPGLTASAFIPHPFAKEPGARLYRTGDIGVYDAQGHIYFLGRQDNRVKLH"
     aSModule        816..3443
                     /complete
                     /domains="nrpspksdomains_ctg167_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg167_1_PCP.1"
                     /domains="nrpspksdomains_ctg167_1_Epimerization.1"
                     /locus_tags="ctg167_1"
                     /monomer_pairings="tyr -> D-tyr"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       1002..1043
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0004"
                     /evalue="8.00E-06"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg167_1"
                     /protein_end="347"
                     /protein_start="333"
                     /score="18.9"
                     /tool="antismash"
                     /translation="LAVLKAGGAFVPLDT"
     CDS_motif       1227..1286
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0005"
                     /evalue="5.80E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg167_1"
                     /protein_end="428"
                     /protein_start="408"
                     /score="34.1"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVLVTHA"
     CDS_motif       1773..1862
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0006"
                     /evalue="9.50E-17"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg167_1"
                     /protein_end="620"
                     /protein_start="590"
                     /score="53.1"
                     /tool="antismash"
                     /translation="PPGIPGEICIGGIGLARGYLNRPGLTASAFI"
     CDS_motif       1950..2015
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0007"
                     /evalue="1.30E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg167_1"
                     /protein_end="671"
                     /protein_start="649"
                     /score="30.2"
                     /tool="antismash"
                     /translation="FLGRQDNRVKLHGYRIELGEIEA"
     aSDomain        2304..2495
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg167_1_PCP.1"
                     /evalue="1.90E-20"
                     /label="ctg167_1_PCP.1"
                     /locus_tag="ctg167_1"
                     /protein_end="831"
                     /protein_start="767"
                     /score="64.6"
                     /tool="antismash"
                     /translation="EKILCQIWTEVLGIEANVNHNFFEIGGDSIMSLQIVSRAREAGLD
                     ISPRDIFEAQTLGRLAAIAK"
     aSDomain        2535..3443
                     /aSDomain="Epimerization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg167_1_Epimerization.1"
                     /evalue="6.60E-117"
                     /label="ctg167_1_Epimerization.1"
                     /locus_tag="ctg167_1"
                     /protein_end="1147"
                     /protein_start="844"
                     /score="382.9"
                     /tool="antismash"
                     /translation="TGKVPLAPIQHWFFERNLPHSHQWNQTVALSVSEPLKMDAFFMAL
                     EAIVAHHDAFRLEFDQNQGIWEQSYTAAASPPLRIKDFSTYPPNEQRHALDAVVAEEQE
                     LIDLKSPPLLRVLYAKNLEEYGDVLIFFGHHLIVDGVSWRIIFEDLNQAYCQAAMGKPV
                     SLPARSSSYRQWTTSLEKLASSPEIVQDLSFWQETLAHKSAALPLDSLAPESNTVASLV
                     VETSQLSSRETLSLLKEAIATYHAGVQEILLAALLKTLTDWSDSSHVLIDLEGHGREDL
                     GSGLDISRTVGWFTSLYPVLLQK"
     CDS_motif       2550..2579
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0008"
                     /evalue="1.30E-03"
                     /label="NRPS-E1"
                     /locus_tag="ctg167_1"
                     /protein_end="859"
                     /protein_start="849"
                     /score="11.9"
                     /tool="antismash"
                     /translation="LAPIQHWFFER"
     CDS_motif       2622..2711
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0009"
                     /evalue="4.00E-03"
                     /label="C2_dual_024-063"
                     /locus_tag="ctg167_1"
                     /protein_end="903"
                     /protein_start="873"
                     /score="9.8"
                     /tool="antismash"
                     /translation="LSVSEPLKMDAFFMALEAIVAHHDAFRLEFD"
     CDS_motif       2919..2984
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0010"
                     /evalue="1.40E-10"
                     /label="NRPS-E2"
                     /locus_tag="ctg167_1"
                     /protein_end="994"
                     /protein_start="972"
                     /score="33.4"
                     /tool="antismash"
                     /translation="LIFFGHHLIVDGVSWRIIFEDLN"
     CDS_motif       3390..3440
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0011"
                     /evalue="2.80E-09"
                     /label="NRPS-E5"
                     /locus_tag="ctg167_1"
                     /protein_end="1146"
                     /protein_start="1129"
                     /score="28.8"
                     /tool="antismash"
                     /translation="DISRTVGWFTSLYPVLLQ"
     aSDomain        3465..3932
                     /aSDomain="TIGR01720"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg167_1_TIGR01720.1"
                     /evalue="4.50E-41"
                     /label="ctg167_1_TIGR01720.1"
                     /locus_tag="ctg167_1"
                     /protein_end="1310"
                     /protein_start="1154"
                     /score="132.0"
                     /tool="antismash"
                     /translation="LENLLKEVKKQIRAIPNHGISFGLLRYLNQNPDTRETLTHLDKPQ
                     ISFNYLGQVDNQQNSNNIFSLSNVPTGSGMFAKQERPHILAINARVQGECLWVDWSYSK
                     HLHNAQTIRHLAESYLHNLRAYLTNSIQYQASFYTTSDFRLVELTDNELDSLL"
     CDS_motif       3486..3548
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg167_1_0012"
                     /evalue="3.20E-09"
                     /label="NRPS-E6"
                     /locus_tag="ctg167_1"
                     /protein_end="1182"
                     /protein_start="1161"
                     /score="29.0"
                     /tool="antismash"
                     /translation="VKKQIRAIPNHGISFGLLRYLN"
     CDS             4256..7273
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 174.8;
                     E-value: 4e-53)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg167_2"
                     /sec_met_domain="Pkinase (E-value: 4.2e-35, bitscore:
                     108.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIALTGVAIESKIYESPASLVYRGIRVRDNLPIIVKMLKQDYPSS
                     QELTRYKQEYEITRSLNIEGVVKAYTQQEYQRTLVIFLEDFGGESLERWMQKRSDFFPM
                     PLFAFLRLAINLTDILGKIHAANVIHKDINPGNIVLNLDTGVVKIIDFGIATQFKRTNP
                     TFKSPHVLEGTLAYLSPEQTGRMNRLLDYRTDFYSLGVTFYELLTGQLPFPTTDVLELV
                     HCHIAKQPPLPHELNVTIPKVVSDIVLKLMMKNAEDRYQSAWGVKADLEICAEQLEEVG
                     HINSIQLGLQDVSGQFQIPQKLYGREAEIAALLAAFEKVATRGNVDEAPRSEESIENPQ
                     FKVEMMLVSGFAGIGKSALVQELYKPITTKRGYFISGKFDQLERNIPYRAITHALQKLV
                     QQLLGEPDEQLQHWRSRLLTALGSNGQIIIDVIPEVELIIGKQPPVPDVGATQAQNRFN
                     RIFGQFVRVFCSKEHPLVIFLDDLQWIDSATLTLIDLMLLDEQTQFLFLIGAYRDNEVN
                     PTHPLVLALSRLRKQGSVLHKIALAPLTLEPLTQLVAKTLHQNANTVRPLAELVLRKTE
                     GNPFFVGEFLQSLYNENLLIFNTEHLTWQWNIAQIQTQNITDNVVELLLLKLKKLPEVT
                     QQLLRLAACIGAEFDLETLGIICEKSPQVVSLDLLAAIQAGLVQPLSELDENLLIQEYK
                     FLHDRVQQAAYVLIDESQKQLVHLQIGYNLLEKRLPERLSERLFETVDHLNYGIELVSD
                     QAKRDEIAKLNLLAAQKAKAAIAHNVAKKYLATAQGWLAASSWQTNYSLTLDLYLETTE
                     VAYLCGDFEEVEYWAAIVLQAAKTVLDTMKVYEVKIQTYIAQNQRLEAINTALQVLQQL
                     GISFPETPSQSDIHLQLDAIISCLDNKPIKDLIQLPEMVQQELLAAMQILSKTTLIAYH
                     VAPDLGPLLVFKQTNLSIQYGNMFVSPFAYANFGLILCGIVGNIETGYEFGHLALRLLP
                     HLNIYSLKARTLFMVTN"
ORIGIN
        1 aacaacagct tgcagggatt tctgaaccca accccatatc atggaagcca gtcgaaaaga
       61 ttgaaagaca agataccact gactatgggg ctgtggaatt acgtctgagt gatgaggaat
      121 ttgccaacgt gctgcagatg gcgcaaaacc atcgactcac actcaacacc ttagcacaag
      181 gagcatgggc actcctatta caaaaatatg gtgctggaga agatgtgctc tttggcgtca
      241 ctgtttccgg tcgtcccccg gaaatttctg gggtagaaga catggtgggg ctgtttatca
      301 acactctccc catgcgaatt tccctcagtc ctaataccgt tgtcacctct tggctagaag
      361 acattcagca acgtcaggcg caaatgcggg agtatgaata tagtaaactc acagatatcc
      421 gtcaggcgat cgcattcccg gctgccgaat ctttgtttga aagtatattg gtgtttgaga
      481 attaccctgt tgaccagtct ttaaaaaatc aggggcaagg aattcaagta gatgatatcc
      541 agttctatga aagaaccaat taccccctga ctgttgcttt tattccacat agcggactct
      601 tattaaaact caactacgag acaaaattct tgtctcctca tgcagcagaa atcatgctgc
      661 aacgcctgcg caatctcctg ttacagctgg ctcaaaatcc aaatgcccca ttaggaaaca
      721 tagcactttt atctaccgaa gaacacaatc tcactgtcaa tgagtggaac gccaattcta
      781 ttgattgggg ggattttcgt gctgcccatc aactttttga agaccaagca gacttggaca
      841 aagatgcaat tgcattggtg ctaggtgaag attctatcac ctatggtgaa ttagaacaaa
      901 aggcaaatac actcgctgcc acactcaaat ccgcaggtgt caatgatgga tctttagtcg
      961 ggttatattt tgaaccctca attgattttg tcgtagcact tttagctgtg ctgaaagcag
     1021 gaggcgcatt tgttccatta gacaccacct acccagaaga acgcttaaag tttattttgg
     1081 aagatagcca agctaatttt attttggcaa aagaagttgt gccattcaag cataactatg
     1141 agcatagtaa agtcattgcg ctgtcagaga ttgaatggac gcatcatcct aagcgcctaa
     1201 acctgaacat caatgcattg catctagcct atgtgattta cacctccggt tccacaggca
     1261 aaccaaaggg tgttcttgtc acccacgcag ggattcaaaa cctagttcag acacaaacag
     1321 caacttttgg tgtcacaaac caaagtcggg tttaccaatt tgcctcgctg aattttgatg
     1381 cagcaatctc cgaaatcttt atggcactgg gtagcggtgc cactttatac ctaacatcca
     1441 aggcagaccg ctttccggga cctgctcttt gggaagcttt aactgcatgg aaaattagcc
     1501 atttaactct tgtgccatct gtgttggcaa caatcaaacc agaagaactg ccagagttac
     1561 aaactttaat cgtcgcagga gaagcagctt ctggcaatct tttgcaccgc tggggtgaca
     1621 aggaacgcca agttttcaac gcttatggtc ccacagaagc gactgtctgt gccagtatga
     1681 tggactgttc tcacctagtc ggtgaaccaa gtattgggcg cggcatggct aatacagaat
     1741 tatacctcct agacccgtat tttcaacctg tgccacctgg gattccaggg gagatttgta
     1801 tcggtggaat aggtttggca cgtggttatt taaatcgacc agggttaacc gcatctgctt
     1861 ttattcccca tccctttgct aaagaaccgg gggcgcggct ttaccgcaca ggagatattg
     1921 gtgtttacga tgcccaaggt catatttatt tcctcggtcg ccaggataat cgtgtcaaat
     1981 tgcacggata tcgtatcgaa ctaggcgaaa tcgaagcagc tttagcagaa cacgcagtgg
     2041 tagaaagtgc tgtggtgatg ttgcgggaag atgtccccgg acacccgcga ctcgtagcat
     2101 acgtcttgac accaagcgaa gaaatcactt ctcaagaatt gctaaatgat ttatccgcag
     2161 tgcttccagc atacatggtt ccaagtgcgg tggtatttgt caaggaatgg tctttaaccc
     2221 caaatggaaa aattgaccgc aaagcacttc ctgcacctga aatgccaact gggcaattct
     2281 caaccatcgc caccaatgaa acagagaaga tattgtgtca gatctggact gaggttcttg
     2341 ggattgaagc aaacgttaat cacaacttct ttgagatcgg tggcgactcc atcatgagtt
     2401 tgcaaattgt ttcccgcgcc cgcgaagcag gattagatat tagccccaga gacatttttg
     2461 aagcccaaac tttgggaaga ttagcagcga tcgccaaacc attacgtcag tcaataacag
     2521 ttgacgaagc tttaacaggc aaagtgccac ttgcgccaat tcagcattgg ttctttgaaa
     2581 ggaacttacc acattcccac caatggaacc aaacagtagc cctgagtgtc agtgaaccat
     2641 taaaaatgga cgcctttttc atggctttgg aagctatagt cgcccatcat gatgcttttc
     2701 gattggaatt cgaccaaaat cagggcatct gggaacaatc atatacggct gctgcaagtc
     2761 ccccattacg tattaaggac tttagcacct atccacccaa tgaacaaaga catgccttag
     2821 acgctgttgt cgcagaagaa caggagttga ttgatctgaa gagtccaccc ttgttgagag
     2881 ttctctatgc caaaaaccta gaggaatacg gtgatgtgct gatattcttt ggtcatcatt
     2941 tgattgttga tggagtctcc tggcgcatca tttttgagga cttaaaccaa gcttactgtc
     3001 aagctgctat gggcaaacct gtttccttac ctgctagaag ttcttcctac agacagtgga
     3061 cgacaagcct agaaaaattg gcttcttcac cagaaattgt acaagacctc tcattttggc
     3121 aggaaacatt agcacataag agtgcagcat tacctctaga tagcctcgcc cctgaaagca
     3181 atacagtggc aagtttagtt gtggaaactt cacaactctc ctctagggaa accttatctc
     3241 tactgaaaga agcgatcgcc acttaccacg ccggggtaca agaaattctt ctggctgcat
     3301 tgctcaaaac tctaaccgac tggagtgact catcccatgt actgattgat ttagaaggac
     3361 acggtcgaga agatttaggc agtgggttgg atatttccag aactgtaggt tggtttacct
     3421 ccctttatcc tgttctcctg caaaaacccc aggaaaatga gaacttagaa aacttgctta
     3481 aggaagtgaa aaaacaaatc cgagccattc ccaatcatgg cataagcttt ggtctcttgc
     3541 gttatttaaa tcagaaccca gacacacgcg aaacactaac tcatttagac aagccccaaa
     3601 tcagcttcaa ttacctggga caagtggaca accaacaaaa cagcaacaac attttcagcc
     3661 tcagtaacgt tcccacaggt tcaggcatgt ttgccaaaca agagcgtcct catattttag
     3721 cgataaatgc ccgtgtccaa ggcgaatgtc tatgggttga ttggtcttat agcaaacatc
     3781 tccataacgc ccaaaccata cgtcatctgg cagaaagtta cttgcacaac ctacgtgctt
     3841 atctcaccaa ttcaatacaa tatcaagcat ctttttatac gacttctgat tttcgtctgg
     3901 ttgaattaac tgataatgag ctcgattctc ttttggaaga tttggggtga aatccggggt
     3961 gtagggtgtg gggtgtaggg acaagttcaa ggtcttgaaa ttgtcacctc tatctactgt
     4021 gtctccttcc tagctctctc cccctttgtt acgaattatg tgactaatgc ataggccata
     4081 gccgtaggtt tgggtggggt gcgttcaaat ctttgctgac agatttacga gcactgctaa
     4141 gtacggaaga ttaatcagca tagtatttgt tttcgtgata gttttttatt gaagtcctgt
     4201 aatgaaaggt ataatttctg atgaggctta atgacactca tcgagaaaaa gttcaatgat
     4261 agccctaacc ggagttgcca tcgaaagtaa aatctatgaa agtccggcat ctctagtata
     4321 ccgaggcatc agagtgcgag ataatctgcc aattatcgtt aaaatgctaa agcaagatta
     4381 tccctcatct caagaattaa ctcgctacaa acaagaatat gaaattaccc gctccctgaa
     4441 catagaaggc gtggtcaagg catacaccca gcaggagtat caacgtacac tcgttatttt
     4501 tttagaagac tttggcggag aatccctaga gcgatggatg caaaaacgtt cagatttttt
     4561 ccccatgccc ttatttgctt ttttgcgtct tgccatcaac ctaacagata ttctgggcaa
     4621 aatccatgca gccaatgtca ttcataagga tatcaaccct ggcaacatag ttttaaatct
     4681 agatactggt gttgtcaaaa tcattgattt cgggatagcc acccaattta aacgcacgaa
     4741 tccaactttt aaaagccctc acgttttaga agggacactc gcctacctgt ctccagagca
     4801 aacaggccgg atgaaccgtc tgctggatta ccgcactgat ttttactcgc tgggtgtaac
     4861 gttttacgaa ctgctcaccg gacaactgcc gtttcccaca acggacgtgc ttgaactagt
     4921 ccattgtcat attgccaaac agccgcctct gcctcatgag ttgaatgtaa cgattcccaa
     4981 agtcgtttca gatattgttt tgaaactgat gatgaagaat gcggaagacc gctatcagag
     5041 tgcttgggga gtcaaagcgg acttagaaat ctgtgctgag caattggagg aagtcggtca
     5101 cattaacagt attcaactgg gtttgcaaga cgtttcgggt caatttcaaa ttccccaaaa
     5161 gctatacgga cgagaagcag agattgcagc attattggcg gcttttgaaa aagtagccac
     5221 aagaggaaac gttgacgaag ccccccgttc agaggaaagt atagaaaatc ctcaattcaa
     5281 agtcgaaatg atgctagtct ctggctttgc tggaattggt aaatcagcat tggtgcagga
     5341 actatataaa cccatcacaa ctaagcgtgg ctattttatc tccggtaaat ttgatcaatt
     5401 agagcgtaat ataccttata gagccatcac tcatgctctg caaaaattgg tgcaacaact
     5461 tctaggtgaa cctgatgaac agttgcaaca ttggcgatca cgacttttaa ccgctttagg
     5521 aagtaatgga caaatcatca ttgatgtcat cccagaagtt gaattaatta ttggcaagca
     5581 gcctccggta ccagatgttg gagcaaccca agctcaaaat cgcttcaatc gcatctttgg
     5641 ccagtttgtg cgggtgtttt gttcaaagga acacccgctt gttatctttt tagatgattt
     5701 gcagtggata gattcagcaa cacttacgtt aatcgatctg atgctgcttg atgagcaaac
     5761 ccaattcctg tttttaattg gggcttatcg agataatgag gtgaatccaa cgcatccact
     5821 ggtattagca ctctcaagac tgcgcaaaca aggatctgtg cttcataaga ttgccctggc
     5881 acctttaacc ctagaaccat taactcagtt agttgcaaag acactacatc agaatgctaa
     5941 tactgttcgt cccttggctg aattagtgct gcgtaaaacc gagggtaatc ccttctttgt
     6001 tggtgaattc ttgcaatcac tctacaatga aaatctgttg atctttaata cggaacactt
     6061 aacctggcag tggaacattg ctcaaattca aactcagaat attaccgata atgtggtgga
     6121 gttactgctc cttaagttga agaaattacc agaggtgaca cagcagcttc tgcgtttagc
     6181 agcctgtatt ggggctgaat ttgatttaga aacgttaggg attatttgtg aaaagtctcc
     6241 tcaagtagtt tctctagatt tactcgcagc gatacaagct ggactcgttc aacccctgtc
     6301 tgaactagat gaaaacttat taattcaaga gtataaattt ttgcatgacc gggtgcaaca
     6361 agcagcatat gtcttaatcg atgagtcgca aaagcagcta gttcatctcc aaattggtta
     6421 caatctactt gaaaaaaggt tgccagagcg actgtcagag cggttgtttg aaactgttga
     6481 tcatctcaat tatgggattg agcttgtcag tgatcaagca aaacgagatg aaattgccaa
     6541 actgaattta ttggcagctc agaaggcaaa agcagcgatc gcccacaacg ttgctaaaaa
     6601 atatttagcc acagcccaag gatggctagc tgcttctagc tggcaaacaa actatagctt
     6661 gacattagat ttatatttag aaacaacaga agtcgcgtat ttatgtggcg attttgagga
     6721 ggtggaatat tgggcggcga ttgttctgca agctgccaag acagttctcg ataccatgaa
     6781 agtctacgaa gtcaaaattc aaacttacat cgcacagaac cagcgattag aagcaatcaa
     6841 tactgcatta caagttttgc agcaattagg gatcagtttt cccgaaacgc caagtcaatc
     6901 agatattcat cttcaactcg acgcaatcat atcctgcttg gacaacaaac cgatcaagga
     6961 cttgatccaa ttgccagaaa tggttcagca agagttgcta gcagcaatgc aaattctatc
     7021 taaaacaacg ctcattgcct atcatgtggc tcctgattta gggcctctac ttgtgtttaa
     7081 acagacaaac ttgtcaattc agtatggcaa tatgtttgtt tctccctttg cctatgccaa
     7141 ttttggttta attctttgtg ggatagtggg aaacattgag actggctacg agtttgggca
     7201 tctggcatta aggctgttac ctcatctgaa catctattca cttaaagcca gaacattgtt
     7261 catggtaacg aactt
//
