3300028400_14 - 2 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

c00030_3300028.. (original name was: 3300028400.a:Ga0256832_1000029)

Region	Type	From	To	Most similar known cluster		Similarity
Region 30.1	terpene	57,298	78,997

c00037_3300028.. (original name was: 3300028400.a:Ga0256832_1000002)

Region	Type	From	To	Most similar known cluster		Similarity
Region 37.1	NRPS,T1PKS	296,858	405,320

Region	Type	From	To	Most similar known cluster	Similarity
Region 30.1	terpene	57,298	78,997
Region 37.1	NRPS,T1PKS	296,858	405,320

No secondary metabolite regions were found in these records:: c00001_3300028.. (original name was: 3300028400.a:Ga0256832_1032567); c00002_3300028.. (original name was: 3300028400.a:Ga0256832_1000013); c00003_3300028.. (original name was: 3300028400.a:Ga0256832_1000006); c00004_3300028.. (original name was: 3300028400.a:Ga0256832_1002828); c00005_3300028.. (original name was: 3300028400.a:Ga0256832_1000005); c00006_3300028.. (original name was: 3300028400.a:Ga0256832_1000047); c00007_3300028.. (original name was: 3300028400.a:Ga0256832_1020644); c00008_3300028.. (original name was: 3300028400.a:Ga0256832_1000004); c00009_3300028.. (original name was: 3300028400.a:Ga0256832_1015886); c00010_3300028.. (original name was: 3300028400.a:Ga0256832_1000086); c00011_3300028.. (original name was: 3300028400.a:Ga0256832_1000007); c00012_3300028.. (original name was: 3300028400.a:Ga0256832_1029880); c00013_3300028.. (original name was: 3300028400.a:Ga0256832_1000032); c00014_3300028.. (original name was: 3300028400.a:Ga0256832_1000018); c00015_3300028.. (original name was: 3300028400.a:Ga0256832_1000003); c00016_3300028.. (original name was: 3300028400.a:Ga0256832_1000193); c00017_3300028.. (original name was: 3300028400.a:Ga0256832_1000194); c00018_3300028.. (original name was: 3300028400.a:Ga0256832_1000113); c00019_3300028.. (original name was: 3300028400.a:Ga0256832_1029239); c00020_3300028.. (original name was: 3300028400.a:Ga0256832_1001279); c00021_3300028.. (original name was: 3300028400.a:Ga0256832_1000072); c00022_3300028.. (original name was: 3300028400.a:Ga0256832_1027483); c00023_3300028.. (original name was: 3300028400.a:Ga0256832_1031875); c00024_3300028.. (original name was: 3300028400.a:Ga0256832_1020612); c00025_3300028.. (original name was: 3300028400.a:Ga0256832_1000028); c00026_3300028.. (original name was: 3300028400.a:Ga0256832_1000033); c00027_3300028.. (original name was: 3300028400.a:Ga0256832_1000110); c00028_3300028.. (original name was: 3300028400.a:Ga0256832_1031460); c00029_3300028.. (original name was: 3300028400.a:Ga0256832_1004601); c00031_3300028.. (original name was: 3300028400.a:Ga0256832_1000014); c00032_3300028.. (original name was: 3300028400.a:Ga0256832_1020901); c00033_3300028.. (original name was: 3300028400.a:Ga0256832_1001175); c00034_3300028.. (original name was: 3300028400.a:Ga0256832_1000170); c00035_3300028.. (original name was: 3300028400.a:Ga0256832_1028432); c00036_3300028.. (original name was: 3300028400.a:Ga0256832_1029577); c00038_3300028.. (original name was: 3300028400.a:Ga0256832_1000001); c00039_3300028.. (original name was: 3300028400.a:Ga0256832_1030584)

Compact view

c00037_3300028.. - Region 1 - NRPS,T1PKS

Download region GenBank file

Location: 296,858 - 405,320 nt. (total: 108,463 nt) Show pHMM detection rules used

NRPS: (cds(Condensation and (AMP-binding or A-OX)) or (Condensation and AMP-binding))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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NRPS/PKS domains

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 296857 - 405320:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (redmal) + (mal - tyr) + (ohmal) + (X) + (X - D-X) + (phe - phe) + (X - D-X) + (X - phe) + (orn - asn - tyr - tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg37_265

Search NORINE for peptide: strict or relaxed

AMP-binding (481..888): orn

NRPSPredictor2: orn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGElaSIDK
Nearest Stachelhaus code:: orn
Stachelhaus code match:: 80% (moderate)

AMP-binding (1555..1954): asn

NRPSPredictor2: asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: asp, asn
Single AA prediction:: asn

Stachelhaus prediction details:

Stachelhaus sequence:: DATKVGEVGK
Nearest Stachelhaus code:: asn
Stachelhaus code match:: 100% (strong)

AMP-binding (2616..3002): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASTIAAVgK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 90% (moderate)

AMP-binding (3658..4046): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: tyr

Stachelhaus prediction details:

Stachelhaus sequence:: DASTiAAIGK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 90% (moderate)

ctg37_266

Search NORINE for peptide: strict or relaxed

AMP-binding (468..864): X

NRPSPredictor2: tyr, bht

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: tyr, bht
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAgTAVgvgK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 60% (weak)

AMP-binding (1523..1921): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTIAaVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 90% (moderate)

ctg37_267

Search NORINE for peptide: strict or relaxed

AMP-binding (495..910): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAeDIGtVvK
Nearest Stachelhaus code:: glu
Stachelhaus code match:: 70% (weak)

AMP-binding (1922..2320): X

NRPSPredictor2: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: orn, lys, arg
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAQDLGmVDK
Nearest Stachelhaus code:: gln
Stachelhaus code match:: 90% (moderate)

ctg37_268

Search NORINE for peptide: strict or relaxed

AMP-binding (469..863): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DAyTLAgVAK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 80% (moderate)

AMP-binding (1523..1928): phe

NRPSPredictor2: phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: phe, trp
Single AA prediction:: phe

Stachelhaus prediction details:

Stachelhaus sequence:: DAWTIAaVCK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 90% (moderate)

ctg37_269

Search NORINE for peptide: strict or relaxed

AMP-binding (508..927): X

NRPSPredictor2: hydrophobic-aliphatic

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DaEdiGTiVK
Nearest Stachelhaus code:: lys-b
Stachelhaus code match:: 60% (weak)

AMP-binding (2362..2763): X

NRPSPredictor2: hydrophilic

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVYyLGgiCK
Nearest Stachelhaus code:: hpg
Stachelhaus code match:: 70% (weak)

ctg37_270

Search NORINE for peptide: strict or relaxed

AMP-binding (503..906): X

NRPSPredictor2: glu, gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: glu, gln
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAenIGAItK
Nearest Stachelhaus code:: leu
Stachelhaus code match:: 70% (weak)

ctg37_271

PKS_AT (540..836): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 162.5
inactive: 116.3
Methoxymalonyl-CoA: 69.1
Methylmalonyl-CoA: 61.3
Propionyl-CoA: 47.5
Isobutyryl-CoA: 30.1
Ethylmalonyl-CoA: 29.8
CHC-CoA: 26.6
2-Methylbutyryl-CoA: 22.5
Benzoyl-CoA: 15.6
Acetyl-CoA: 11.5
fatty_acid: 10.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

ctg37_272

Search NORINE for peptide: strict or relaxed

PKS_AT (563..859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 172.7
inactive: 136.4
Methoxymalonyl-CoA: 73.1
Methylmalonyl-CoA: 65.3
Propionyl-CoA: 52.1
Ethylmalonyl-CoA: 33.4
Acetyl-CoA: 31.8
Isobutyryl-CoA: 30.9
Benzoyl-CoA: 30.0
2-Methylbutyryl-CoA: 22.7
CHC-CoA: 21.3
trans-1,2-CPDA: 17.1
fatty_acid: 9.9
3-Methylbutyryl-CoA: 0.0

AMP-binding (1521..1915): tyr

NRPSPredictor2: tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic
Large clusters prediction:: phe, trp, phg, tyr, bht
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASTIAAVCK
Nearest Stachelhaus code:: tyr
Stachelhaus code match:: 100% (strong)

ctg37_273

CAL_domain (176..492): pk

minowa: NH2

Prediction, score:

NH2: 122.8
Acetyl-CoA: 55.8
fatty_acid: 21.6
AHBA: 12.5
shikimic_acid: 0.0

PKS_AT (1234..1530): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 149.5
inactive: 145.2
Methoxymalonyl-CoA: 77.1
Methylmalonyl-CoA: 72.2
Propionyl-CoA: 46.0
Ethylmalonyl-CoA: 38.2
Isobutyryl-CoA: 34.2
Benzoyl-CoA: 32.4
2-Methylbutyryl-CoA: 25.9
CHC-CoA: 21.4
trans-1,2-CPDA: 17.5
Acetyl-CoA: 17.1
fatty_acid: 8.3
3-Methylbutyryl-CoA: 6.0