LOCUS       c00499_3300028..        4343 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300028622.a:Ga0302253_1006107.
ACCESSION   c00499_3300028..
VERSION     c00499_3300028..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 05:08:53
            Original ID  :: 3300028622.a:Ga0302253_1006107
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 4343
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..4343
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:4343](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3..4343)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..4343
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..4343
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             complement(3..4343)
                     /NRPS_PKS="Domain: Condensation_LCL (0-167). E-value:
                     1.1e-53. Score: 174.0. Matches aSDomain:
                     nrpspksdomains_ctg499_1_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (334-718). E-value:
                     2.5e-102. Score: 334.2. Matches aSDomain:
                     nrpspksdomains_ctg499_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (824-887). E-value: 5.2e-15. Score:
                     47.2. Matches aSDomain: nrpspksdomains_ctg499_1_PCP.1"
                     /NRPS_PKS="Domain: NAD_binding_4 (952-1185). E-value:
                     6.1e-52. Score: 167.9. Matches aSDomain:
                     nrpspksdomains_ctg499_1_NAD_binding_4.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     255.6; E-value: 1.7e-77)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg499_1"
                     /sec_met_domain="Condensation (E-value: 3.5e-56, bitscore:
                     176.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-112, bitscore:
                     362.0, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 8.3e-14, bitscore:
                     38.2, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.2e-53, bitscore:
                     167.9, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="RHCLLMDLHHIICDGISISIIFRELARLYHGEQLSAPSVHFKDYV
                     VWHSRYMESDEMEGHAEFWQNSFNGYEPFELVTDYPRTASTAFDGGEYRVVLEKWLSLD
                     LRRLCAESGATMHTILLSAFAALLSRYSGQEDIVVGTSMSGRTLDEVSDMVGMFVNTVP
                     VRCQAAAGRTFRSFVEEIKQTMLSIQEHQDYPLERVYDRLRFHRGPGRNPLFDCNFVLR
                     NMELPQFDSREIKAAVEHIPTHTSKFDISLAAEERDGGAIVFDVEYRTSLYRPETVQAL
                     VSHLIRLLESACAIPDSPIGELDIIYPDERKKLLFDFNSTAVPSPWYRTAVEAFEKAAE
                     SHPDNRAVVAAGTALSYRDLNGKANHLARLLRDRGMKADVIAAILADRSADTVVAMLAV
                     LKAGGAYTCIDPRYPAERAQYIIDDSKAQFLLGKGTLLQQLSFEGSVVALDSLPEQEGC
                     DESPLPSPAPESLAYVIYTSGSTGKPKGVMIEHRSMVNFLHWYTTLHNFTSFDRSAEYA
                     SFTFDASIAQVYAPLVSGAELHIIDEELRLSPPDLNAWFEEQGITHAHFPTQFAEQFML
                     MTENTSLKRLVVGGDSLRRYRTGPFRLTNEYGPSETTVASTAMHVEGRYPRVPIGRPAD
                     NTRIYILDSRRHPVPTGVPGELCIAGAGLARGYLNNPEMTEKKFVPDPFREGEKMYLTG
                     DRARWLPDGNIEFFGRLDFQVKIRGYRIEPGEIEQALKAHCRAAEAVVVARSDQNDGKY
                     LCAYYTSPADVPPHEVKSALAKALPEYMVPSHFIRLDRMPLNQSGKIDRSALPPPELSL
                     GPSERVLPRNETEERIARSWSRVLDSDSFGVFDSFFDAGGDSLRSIALVAELQKDFQVK
                     VNDIFLYPTVAEQALHFREVKDNIKKRLHSLKEHYEQTGFQGDREYLGLPQSRELLSNY
                     RSQYLEYDRKDLSARRAYRHILLTGATGYLGIYLLRELLQSGDWTITVPVRASSPEAAE
                     RRIRDKYQYYFGVDIPEEYRSRLTALMSDLLKDRLGLDEKTYCELSSRIDCIVHSAANV
                     KHYGKYEEFYESNVKATERLLGFALEGVKKDFHHISTTSVGNGSVEGREYVLFTECDGD
                     MGQKTDHVYVRTKQLAEQKVREFREKGVRASIYRCGNITFDSASGMVQENVEDNAFFQV
                     IKSVVNLGVVPERVNERNISFVNESAQAIVRLFDREAFQNEVFHISNPHKVQISEILAS
                     PDLDLDVKAADLPDFLDFMIAHYDHEGFKAYIEKLMLHFGWYDGQDQKHTHCVIITDRT
                     EHLLARLGFKWSQPEPGLVKNMIRRALRERAAQIAGTMSFSFLSEEECEAVARKARLVH
                     VEDEVYLARESSGDCNYYLVLRGYLEISRRTRKGWLGTVRVVGSGETIGDVGLLDRKPI
                     PVNLQAYGEALVLSLDAAYLRAMMEKSPRFPMGLVKTLAKRVDQL"
     aSDomain        complement(789..1487)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg499_1_NAD_binding_4.1"
                     /evalue="6.10E-52"
                     /label="ctg499_1_NAD_binding_4.1"
                     /locus_tag="ctg499_1"
                     /protein_end="1185"
                     /protein_start="952"
                     /score="167.9"
                     /tool="antismash"
                     /translation="LTGATGYLGIYLLRELLQSGDWTITVPVRASSPEAAERRIRDKYQ
                     YYFGVDIPEEYRSRLTALMSDLLKDRLGLDEKTYCELSSRIDCIVHSAANVKHYGKYEE
                     FYESNVKATERLLGFALEGVKKDFHHISTTSVGNGSVEGREYVLFTECDGDMGQKTDHV
                     YVRTKQLAEQKVREFREKGVRASIYRCGNITFDSASGMVQENVEDNAFFQVIKSVVNLG
                     VVPERVNERNIS"
     aSDomain        complement(1683..1871)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg499_1_PCP.1"
                     /evalue="5.20E-15"
                     /label="ctg499_1_PCP.1"
                     /locus_tag="ctg499_1"
                     /protein_end="887"
                     /protein_start="824"
                     /score="47.2"
                     /tool="antismash"
                     /translation="EERIARSWSRVLDSDSFGVFDSFFDAGGDSLRSIALVAELQKDFQ
                     VKVNDIFLYPTVAEQALHF"
     aSModule        1683..4343
                     /complete
                     /domains="nrpspksdomains_ctg499_1_Condensation_LCL.1"
                     /domains="nrpspksdomains_ctg499_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg499_1_PCP.1"
                     /locus_tags="ctg499_1"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2160..2225)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg499_1_0007"
                     /evalue="1.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg499_1"
                     /protein_end="728"
                     /protein_start="706"
                     /score="36.6"
                     /tool="antismash"
                     /translation="FFGRLDFQVKIRGYRIEPGEIEQ"
     aSDomain        complement(2190..3341)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg499_1_AMP-binding.1"
                     /evalue="2.50E-102"
                     /label="ctg499_1_AMP-binding.1"
                     /locus_tag="ctg499_1"
                     /protein_end="718"
                     /protein_start="334"
                     /score="334.2"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="FEKAAESHPDNRAVVAAGTALSYRDLNGKANHLARLLRDRGMKAD
                     VIAAILADRSADTVVAMLAVLKAGGAYTCIDPRYPAERAQYIIDDSKAQFLLGKGTLLQ
                     QLSFEGSVVALDSLPEQEGCDESPLPSPAPESLAYVIYTSGSTGKPKGVMIEHRSMVNF
                     LHWYTTLHNFTSFDRSAEYASFTFDASIAQVYAPLVSGAELHIIDEELRLSPPDLNAWF
                     EEQGITHAHFPTQFAEQFMLMTENTSLKRLVVGGDSLRRYRTGPFRLTNEYGPSETTVA
                     STAMHVEGRYPRVPIGRPADNTRIYILDSRRHPVPTGVPGELCIAGAGLARGYLNNPEM
                     TEKKFVPDPFREGEKMYLTGDRARWLPDGNIEFFGRLDFQVKIRG"
     CDS_motif       complement(2307..2396)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg499_1_0006"
                     /evalue="2.10E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg499_1"
                     /protein_end="679"
                     /protein_start="649"
                     /score="52.0"
                     /tool="antismash"
                     /translation="PTGVPGELCIAGAGLARGYLNNPEMTEKKFV"
     CDS_motif       complement(2871..2930)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg499_1_0005"
                     /evalue="9.60E-12"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg499_1"
                     /protein_end="491"
                     /protein_start="471"
                     /score="36.5"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVMIEHR"
     CDS_motif       complement(3114..3155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg499_1_0004"
                     /evalue="1.20E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg499_1"
                     /protein_end="410"
                     /protein_start="396"
                     /score="12.4"
                     /tool="antismash"
                     /translation="LAVLKAGGAYTCIDP"
     CDS_motif       complement(3687..3800)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg499_1_0003"
                     /evalue="9.20E-12"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="ctg499_1"
                     /protein_end="219"
                     /protein_start="181"
                     /score="37.3"
                     /tool="antismash"
                     /translation="KQTMLSIQEHQDYPLERVYDRLRFHRGPGRNPLFDCNFV"
     aSDomain        complement(3843..4343)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg499_1_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.10E-53"
                     /label="ctg499_1_Condensation_LCL.1"
                     /locus_tag="ctg499_1"
                     /protein_end="167"
                     /protein_start="0"
                     /score="174.0"
                     /tool="antismash"
                     /translation="RHCLLMDLHHIICDGISISIIFRELARLYHGEQLSAPSVHFKDYV
                     VWHSRYMESDEMEGHAEFWQNSFNGYEPFELVTDYPRTASTAFDGGEYRVVLEKWLSLD
                     LRRLCAESGATMHTILLSAFAALLSRYSGQEDIVVGTSMSGRTLDEVSDMVGMFVNTVP
                     VRCQA"
     CDS_motif       complement(3849..3938)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg499_1_0002"
                     /evalue="4.00E-12"
                     /label="C5_LCL_267-296"
                     /locus_tag="ctg499_1"
                     /protein_end="165"
                     /protein_start="135"
                     /score="38.5"
                     /tool="antismash"
                     /translation="DIVVGTSMSGRTLDEVSDMVGMFVNTVPVRC"
     CDS_motif       complement(4257..4322)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg499_1_0001"
                     /evalue="3.40E-10"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg499_1"
                     /protein_end="29"
                     /protein_start="7"
                     /score="32.4"
                     /tool="antismash"
                     /translation="LHHIICDGISISIIFRELARLYH"
ORIGIN
        1 gagagctgat ccacccgctt tgcgagcgtc ttcacgaggc ccatcgggaa tctcggcgac
       61 ttctccatca tcgcccgcag gtaagcggcg tccagactca gcactagcgc ttctccatag
      121 gcctgaaggt tgaccggaat gggcttcctg tcgagaagcc cgacatcgcc gattgtctcc
      181 ccgcttccca ccactctcac agtgccgagc cagcctttcc tggtccggcg gctgatctcc
      241 agatatccgc ggagcaccag atagtaattg cagtcgccgc tgctttccct ggcgagatat
      301 acctcatcct ccacgtggac gagcctcgcc ttcctcgcca cagcctcgca ttcctcttcg
      361 ctgaggaacg aaaaggacat cgtcccggcg atctgcgcgg ctctctccct cagcgccctg
      421 cgtatcatgt tcttcacgag gccgggctca ggctgtgacc atttaaatcc gaggcgggcg
      481 agcagatgct cagtcctgtc tgttatgatt acgcagtgag tgtgcttctg atcctggccg
      541 tcgtaccagc cgaagtggag catcagcttt tcgatatacg ccttgaagcc ttcgtggtca
      601 taatgagcga tcatgaaatc cagaaagtcg ggaaggtcgg ccgctttcac gtccagatcg
      661 agatccggcg aggccagtat ctcgcttatc tgcaccttgt gagggttaga gatgtggaat
      721 acctcgttct ggaacgcctc cctgtcaaaa agcctcacga ttgcctgcgc gctctcgttg
      781 acgaaggaga tgttccgctc attgactcgc tccggcacca cgccgaggtt cacgacggac
      841 tttatcacct ggaaaaaggc gttgtcttcc acgttttcct gcaccatccc cgaagccgag
      901 tcaaaggtga tgttgccgca ccggtagatg gacgccctta ctcccttttc cctgaactct
      961 ctcaccttct gctccgcaag ctgcttcgtc ctcacgtaga cgtgatccgt cttctggccc
     1021 atatcgccgt cgcattccgt aaagagcacg tattcgcgcc cttccacact cccattgcca
     1081 actgaggtcg tggagatatg atggaaatcc tttttcactc cttccagcgc aaaaccgaga
     1141 aggcgctcag tggcctttac gttgctctcg taaaactcct catacttccc gtagtgcttc
     1201 acgttggcgg ctgaatggac gatgcagtcg atgcggctcg acagttcgca gtatgtcttc
     1261 tcatcgaggc ccagcctgtc cttcagaagg tctgacatca gggccgtgag cctgcttcga
     1321 tattcctcag gaatgtcaac gccgaaataa tactggtatt tatccctgat tctccgctcc
     1381 gccgcttcag gcgaagaggc cctcactggg acagttatcg tccagtctcc gctctgcagg
     1441 agctctctca gaaggtaaat ccccagatag ccggtggcgc ctgtcagcag gatatggcgg
     1501 taggctctgc gggctgacag gtctttcctg tcgtattcga gatactggct gcgatagttt
     1561 gagaggagct cccggctctg aggcaggccg agatattcgc ggtcgccctg gaatccagtc
     1621 tgctcatagt gttctttcag gctgtggaga cgtttcttta tgttgtcctt cacctccctg
     1681 aaatggaggg cctgctcggc caccgtcgga tacaggaaga tgtcgttcac cttgacctgg
     1741 aagtccttct gaagctcggc cacaagcgcg atggacctga gcgaatcgcc gccggcatcg
     1801 aaaaagctgt cgaacacgcc aaagctatcc gagtcgagaa ctctgctcca cgagcgggct
     1861 atcctctcct ccgtctcgtt ccgcggcagg actctctcgg acgggcccag actgagctca
     1921 ggaggcggga gggcggacct gtctatcttg ccgctctggt tgagcggcat cctgtccagc
     1981 cttatgaaat gagagggcac catgtattct ggcagcgcct ttgccagcgc gctcttcacc
     2041 tcatggggag gaacgtccgc cggagatgtg tagtacgcgc agaggtactt gccgtcattc
     2101 tgatcgctcc gggccacgac gacagcctcg gcggctctgc aatgcgcttt caatgcctgc
     2161 tcgatctcgc caggctcgat cctgtatccc ctgatcttga cctggaaatc gagccggccg
     2221 aagaactcta tgtttccgtc aggaagccac ctggcccggt ctcccgtcaa gtacatcttt
     2281 tcgccttccc tgaatggatc gggcacgaac ttcttctctg tcatctcagg gttgttcaga
     2341 tagcctcggg caagccccgc gccggctatg cacagctctc ccggaacgcc tgtcggcacc
     2401 ggatgccggc gggagtccag aatatatatc cgcgtgttgt cggcaggcct gccgattgga
     2461 accctgggat atctgccttc gacgtgcatc gctgttgaag ccacggttgt ttcgctgggg
     2521 ccgtattcgt ttgtcaggcg gaatggtcct gtcctgtagc gcctgaggct gtcgccgccc
     2581 actacaagcc tcttcagcga cgtgttttca gtcatcagca tgaactgctc ggcaaactgc
     2641 gtcgggaaat gggcgtgcgt gatcccctgc tcctcgaacc aggcgttgag gtccggaggc
     2701 gagagcctga gctcttcatc gatgatgtgg agctccgctc ctgagacaag cggcgcatag
     2761 acctgggcta tcgaggcgtc gaaggtgaaa gaggcgtatt ccgccgagcg gtcgaagctt
     2821 gtgaagttat gcagtgtcgt ataccagtgc aggaagttaa ccatcgagcg gtgctcaatc
     2881 atcactccct tcggctttcc ggtcgagcct gacgtgtata ttacataggc aaggctctca
     2941 ggagccggcg acggcagcgg gctctcatcg catccttcct gctccggaag gctgtcgagc
     3001 gccacaacgc tcccttcgaa gctgagctgc tgtagaagcg tccccttccc gagaagaaac
     3061 tgtgcctttg aatcgtcgat gatatactgg gcgcgctccg ctgggtagcg cggatcgatg
     3121 caggtatatg ctccgcctgc tttcagcacc gccagcattg cgacgacagt atcggctgat
     3181 cggtctgcca ggattgccgc gatgacatca gccttcatcc ccctgtcccg gagaaggcgc
     3241 gccagatgat tcgccttgcc gttcagatcg cgataagaca gcgccgttcc tgcagcgacg
     3301 acagccctgt tatccgggtg actttccgca gccttttcga aggcttctac ggctgtgcgg
     3361 taccacggag agggaacggc agttgagttg aagtcgaaga ggagcttttt cctctcatcc
     3421 ggatagatga tgtccagctc cccgatcggt gaatcgggga tggcgcatgc tgattcgagc
     3481 agcctgatga gatggctcac cagggcctgc accgtctcag gcctgtacag cgacgtcctg
     3541 tactccacgt cgaacacgat ggcgcctcca tcgcgctctt cagccgcaag agatatgtcg
     3601 aacttggagg tatgagtcgg aatgtgctcg actgccgctt tgatctccct gctgtcgaac
     3661 tggggcaatt ccatattgcg gagcacgaag ttgcagtcga agagagggtt cctgccaggc
     3721 cccctgtgga atctgagcct gtcatagacc ctttccagcg ggtagtcctg gtgctcctgg
     3781 atgctgagca tcgtctgctt tatctcttcc acgaaagatc tgaacgttct tccggccgcg
     3841 gcctggcatc tgaccggaac ggtgttgacg aacatcccca ccatatccga gacttcgtcg
     3901 agcgtgcgcc ctgacatcga tgttcccacg acgatatctt cctggccgga atagcgggac
     3961 agaagcgccg cgaaggcgga gagcagaatg gtgtgcattg tggctccgga ctctgcgcag
     4021 agcctcctga gatctagaga gagccatttc tcgagcacaa cccggtattc accgccgtca
     4081 aaggcagtcg acgctgtgcg tggatagtcg gtgaccagct cgaagggctc gtaaccgttg
     4141 aagctgttct gccagaactc ggcgtggcct tccatttcgt cgctctccat atagcgcgaa
     4201 tgccagacca cgtaatcctt gaaatgaacg gaaggggctg aaagctgttc accgtgataa
     4261 agcctggcga gctctctgaa gattatcgag attgaaatgc cgtcgcagat tatatggtga
     4321 agatccatga gcaggcagtg cct
//
