LOCUS       c00070_3300029..       10071 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300029698.a:Ga0245184_103055.
ACCESSION   c00070_3300029..
VERSION     c00070_3300029..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-23 17:34:59
            Original ID  :: 3300029698.a:Ga0245184_103055
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10071
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10071
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3674](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(3..3674)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..10071
                     /SMILES="NC(C)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(Condensation and (AMP-binding or
                     A-OX)) or (Condensation and AMP-binding))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10071
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="(cds(Condensation and (AMP-binding or A-OX)) or
                     (Condensation and AMP-binding))"
                     /tool="antismash"
     CDS             complement(3..3674)
                     /NRPS_PKS="Domain: AMP-binding (19-418). E-value: 6.6e-103.
                     Score: 336.1. Matches aSDomain:
                     nrpspksdomains_ctg70_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (520-584). E-value: 7.6e-10.
                     Score: 31.0. Matches aSDomain:
                     nrpspksdomains_ctg70_1_PP-binding.1"
                     /NRPS_PKS="Domain: Condensation_LCL (597-876). E-value:
                     1.1e-39. Score: 127.9. Matches aSDomain:
                     nrpspksdomains_ctg70_1_Condensation_LCL.1"
                     /NRPS_PKS="type: NRPS"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     169.9; E-value: 1.8e-51)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_1"
                     /sec_met_domain="Condensation (E-value: 8.3e-45, bitscore:
                     141.7, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 4.9e-109, bitscore:
                     353.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 8.9e-11, bitscore:
                     31.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAINDTRFDFDFRPVTKLFEEQVSLNPHKTAVISGGESLTYTQL
                     NERANRIANSLIEKGAGREKLVGVMLERCCDFYSVRQGILKSGSAFVVAAPDYPDDRVE
                     YIFEDSQAMLVITTSDIAEKRKELFSKLKCEVLLLDKLLENKNTANPNVEIKEHDLCYC
                     IYTSGSTGKPKGVIIEHINLANFVNPNPKNGELLGFTERGTVVLAMAAMTFDVSIMEEF
                     IPLTNGLTAVIASDEEILNPLMLGELIIKNNVDVMATTPTYVSNIVDLPQLRAAISQIK
                     VFDFGAEAFPPALYDKLRSVNPNAYIMNGYGPTEATISCTMKVIDSNSKITIGVPNSNV
                     KVYIVDKDNKLLPDGESGELVIAGLGVGRGYVNLPEKTAAVFIELNGERAYKTGDLAKI
                     NEDGEIEFFGRIDNQIKLRGLRIELGEIEEVINSLDGVLTSVTVPVDNKYLCCYFTADR
                     KIGTDEIIDYASKSLAHYMVPEVFIQLEKMPMTQNGKIDKKALPKPVVQPENLKEPKTQ
                     MQKKIFDIVAKVVGNDFFGIDTELYRAGLSSVSAMKLCIVLSDEFGVTIKTGDIHDNNT
                     VEKLENYIKLAPKIRTYEKRDVYPLAGSQKGIFAECSKNPDSTVYNIPFLFKLDSNIDT
                     EKLSNAITNIVKAHSYLLTRVFLDDNGEMVQSPCNEEFIPKIIRLTNEEFNSVKNNLVR
                     PFKLEKSRLFRAEIYVTEDKKYLLTDFHHIIADGNSYDIIFADINKSYLGEELEKEAYT
                     GFDAALDEEQQIKDGKYKKAEKYFDSIFDGLETESLPLPDNSGDKPEKGYTEKHIRISE
                     NKILSYCDKLGVTPNTLFTGLFGILMTKYSNSDDSLFATIYNGRNDSRLENTVCMLVKT
                     LPVYCSFENKTTIQAYMSKLSQQLVSSMANDIFPFSDICAKYGLNSDLVFAYQAELSDD
                     YPIGDTVANGIDLSLDMPKMPLLIQVRDYNNEYVLTAEYRSDMYSKAFVDEILEAYEAA
                     MSSMLKSKYISEISIISENALNKIAQFNSTESEYDRQKTISDAFDDIVKAEPDNTAVVF
                     KDRKYTYKELDEISDRLGKHILSMGIGREDVVAILIPRCEFMAIAPFGVIKAGAAYQPL
                     DPTYPKDRLMYMLEDSSAKLLIADRELLPLVDGFKGKVLFTDEIMQLEDKNIELKKPGL
                     HDLFILLYTSGSTGVPKGCMLEYGNITAFCHWYKKYYDVDYNTKLAAYASFGFDASMM"
     CDS_motif       complement(111..161)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg70_1_0008"
                     /evalue="5.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg70_1"
                     /protein_end="1188"
                     /protein_start="1171"
                     /score="22.1"
                     /tool="antismash"
                     /translation="LLYTSGSTGVPKGCMLEY"
     CDS_motif       complement(351..392)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg70_1_0007"
                     /evalue="2.70E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg70_1"
                     /protein_end="1108"
                     /protein_start="1094"
                     /score="14.3"
                     /tool="antismash"
                     /translation="FGVIKAGAAYQPLDP"
     aSDomain        complement(1047..1883)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg70_1_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="1.10E-39"
                     /label="ctg70_1_Condensation_LCL.1"
                     /locus_tag="ctg70_1"
                     /protein_end="876"
                     /protein_start="597"
                     /score="127.9"
                     /tool="antismash"
                     /translation="VYPLAGSQKGIFAECSKNPDSTVYNIPFLFKLDSNIDTEKLSNAI
                     TNIVKAHSYLLTRVFLDDNGEMVQSPCNEEFIPKIIRLTNEEFNSVKNNLVRPFKLEKS
                     RLFRAEIYVTEDKKYLLTDFHHIIADGNSYDIIFADINKSYLGEELEKEAYTGFDAALD
                     EEQQIKDGKYKKAEKYFDSIFDGLETESLPLPDNSGDKPEKGYTEKHIRISENKILSYC
                     DKLGVTPNTLFTGLFGILMTKYSNSDDSLFATIYNGRNDSRLENTVCMLVKTLPVYCS"
     aSModule        1047..1883
                     /domains="nrpspksdomains_ctg70_1_Condensation_LCL.1"
                     /incomplete
                     /locus_tags="ctg70_1"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(1452..1514)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg70_1_0006"
                     /evalue="6.40E-05"
                     /label="C3_LCL_132-143"
                     /locus_tag="ctg70_1"
                     /protein_end="741"
                     /protein_start="720"
                     /score="15.7"
                     /tool="antismash"
                     /translation="FHHIIADGNSYDIIFADINKSY"
     CDS_motif       complement(1728..1820)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg70_1_0005"
                     /evalue="1.30E-04"
                     /label="C2_LCL_024-062"
                     /locus_tag="ctg70_1"
                     /protein_end="649"
                     /protein_start="618"
                     /score="14.4"
                     /tool="antismash"
                     /translation="TVYNIPFLFKLDSNIDTEKLSNAITNIVKAHS"
     aSDomain        complement(1923..2114)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg70_1_PP-binding.1"
                     /evalue="7.60E-10"
                     /label="ctg70_1_PP-binding.1"
                     /locus_tag="ctg70_1"
                     /protein_end="584"
                     /protein_start="520"
                     /score="31.0"
                     /tool="antismash"
                     /translation="KIFDIVAKVVGNDFFGIDTELYRAGLSSVSAMKLCIVLSDEFGVT
                     IKTGDIHDNNTVEKLENYIK"
     aSModule        1923..3617
                     /complete
                     /domains="nrpspksdomains_ctg70_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg70_1_PP-binding.1"
                     /locus_tags="ctg70_1"
                     /monomer_pairings="ala -> ala"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2391..2456)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg70_1_0004"
                     /evalue="2.20E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg70_1"
                     /protein_end="428"
                     /protein_start="406"
                     /score="32.6"
                     /tool="antismash"
                     /translation="FFGRIDNQIKLRGLRIELGEIEE"
     aSDomain        complement(2421..3617)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg70_1_AMP-binding.1"
                     /evalue="6.60E-103"
                     /label="ctg70_1_AMP-binding.1"
                     /locus_tag="ctg70_1"
                     /protein_end="418"
                     /protein_start="19"
                     /score="336.1"
                     /specificity="consensus: ala"
                     /tool="antismash"
                     /translation="FEEQVSLNPHKTAVISGGESLTYTQLNERANRIANSLIEKGAGRE
                     KLVGVMLERCCDFYSVRQGILKSGSAFVVAAPDYPDDRVEYIFEDSQAMLVITTSDIAE
                     KRKELFSKLKCEVLLLDKLLENKNTANPNVEIKEHDLCYCIYTSGSTGKPKGVIIEHIN
                     LANFVNPNPKNGELLGFTERGTVVLAMAAMTFDVSIMEEFIPLTNGLTAVIASDEEILN
                     PLMLGELIIKNNVDVMATTPTYVSNIVDLPQLRAAISQIKVFDFGAEAFPPALYDKLRS
                     VNPNAYIMNGYGPTEATISCTMKVIDSNSKITIGVPNSNVKVYIVDKDNKLLPDGESGE
                     LVIAGLGVGRGYVNLPEKTAAVFIELNGERAYKTGDLAKINEDGEIEFFGRIDNQIKLR
                     G"
     CDS_motif       complement(2529..2618)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg70_1_0003"
                     /evalue="3.00E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg70_1"
                     /protein_end="382"
                     /protein_start="352"
                     /score="38.7"
                     /tool="antismash"
                     /translation="PDGESGELVIAGLGVGRGYVNLPEKTAAVFI"
     CDS_motif       complement(3135..3194)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg70_1_0002"
                     /evalue="1.00E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg70_1"
                     /protein_end="180"
                     /protein_start="160"
                     /score="30.3"
                     /tool="antismash"
                     /translation="CYCIYTSGSTGKPKGVIIEHI"
     CDS_motif       complement(3399..3428)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg70_1_0001"
                     /evalue="1.60E+00"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg70_1"
                     /protein_end="92"
                     /protein_start="82"
                     /score="3.0"
                     /tool="antismash"
                     /translation="GILKSGSAFVV"
     CDS             complement(3687..5429)
                     /gene_functions="transport (smcogs) SMCOG1086:MATE efflux
                     family protein (Score: 256.1; E-value: 9.1e-78)"
                     /gene_kind="transport"
                     /locus_tag="ctg70_2"
                     /transl_table=11
                     /translation="MQKRNRRLLSSKLNKYIVPGIMMSLALQLGNIVDTIFVSNFIGVD
                     AMSAITASLPVETIIQLVGYCLGIGGSIAVGIMLGKRDTENASKLFSATLVVTVLVGLI
                     FSALSFFIAEPAAKMLVSGSGLFYYTRDYIFISLLGAPVIGVGLMMISYLGAENHPELA
                     SAYLIAANVINLVLDYIFLNFTPMGIAGASLSTVLGFLIAMVVFVFYARSDKRNISFVR
                     LKLKDFAIIKEAVVTGLPMLVFMATNFVKALGINMIIINLIGDDGLAVFTVCDNVLMIV
                     EMFVGGIIGVIPNVAGVLYGEKDYVGLCVLCNKMLKYSYIVLAVLFVLMMTFTEQIAIM
                     FGSDGGELGVQMVNSLRIFAFCVAPYLWNKFIISYYESIEKTTIASLVTFLENALVVLP
                     ATLVGILIWKQFDGIGIDGIAVGFVASEAITVLAAYIFRKIKYKHSSFYIVPKENPGIN
                     LDFSIQSTMDEAQRVHKEIISFCAENNIPNSKANLAAVCAEEMTVNIIKFGGKSSNWID
                     ISLCLEGDLLRLRIRDNGINFNPLDYENDSNEFDIHGIELVKKISKSMSYIRAIDMNNT
                     IITF"
     CDS             6656..8062
                     /locus_tag="ctg70_3"
                     /transl_table=11
                     /translation="MEKHLKRNSFKGSFGFVLAAAGSAVGLGNIWRFPYLASKDGGGLF
                     LVLYIILALTFGFTLLTTEIAIGRKTKQSPLTAYGQLKKKWKWLGVVACLVPVIIMPYY
                     CVIGGWVLKYFLAYLTGQGTAVAADNYFTSFITSDIEPIVMLILFLGASAFVVFRGVNK
                     GIESFSKVIMPALLLLVVAIAVFSLTLSHTDSNGATRTGLEGLKVYVIPNLSGLTVKSF
                     FSTLLDAMGQLFFSLSVAMGIMIAYGSYVRDDANLNKSINQIEIFDTVVAFLAGVMIIP
                     AVYTFSGIEGMDASGPSLMFISLPKVFAAMGFVGNIIGCLFFAMVLFAALTSAVSVMEA
                     VVSSLMDNFKLSRVKSASIEGIIALVVGILVCLGYNIMYFEASLPNGATGQLLDIMDYV
                     SNNILMPIVAIGTCVLIGWIVKPKTVIDEVEKNGNKMGRKRLYTVMIKFVAPAMLVLLF
                     LKSVGILTVI"
     CDS             8064..8774
                     /locus_tag="ctg70_4"
                     /transl_table=11
                     /translation="MEDFKNGLKNGIPIALGYLSVSFTFGLQAVNGGMSWWQAVLISLT
                     NVTSAGQFAGLDIMTAGAGLWFEMACTQFIINIRYSLMSLSLSQKTDPSIRGIHRFLIA
                     FGITDEIFAVAMGSPNDVSNTYMYGLISLPVLGWCSGTLLGAAAGQLLPEIIRSALNIA
                     IYGMFIAIILPPARKNKAIMAVVIISVLLSCCFKWLPLLNSVSGGFVIIICAVIAAVAG
                     AIFFPVKEEKADGN"
     CDS             8764..9081
                     /locus_tag="ctg70_5"
                     /transl_table=11
                     /translation="MEIKSFFIYLIIMAGVTYLIRMLPFVIFKGKITNTFIKSFLYYIP
                     YAVLGAMTFPAIIFSTGNYSSAVAGLIVACVLAFREKSLLTVAVFACIAALAVNIICLY
                     I"
     CDS             complement(9418..9876)
                     /locus_tag="ctg70_6"
                     /transl_table=11
                     /translation="MMLRTGYYCKYRGKIYSCSLGPTEALLRSHDIEDLEKNGFEKNPY
                     YGKNKFSDVGKYIKEVLKEDVEWFCNIYNVGKYKGRQVGVIRETDTEYVITSGFVSEGE
                     QLFTKENGFEQVDRYLFEGKVPKSEVTDVKEGKEPINKKLKAPDDWNF"
ORIGIN
        1 tccatcatag atgcgtcaaa gccaaaggag gcatatgccg ctaatttggt attgtaatct
       61 acatcataat atttcttata ccaatggcag aaagccgtaa tattgccata ttcaagcata
      121 cagccctttg gtacgcctgt tgaacccgat gtgtacaaaa ggataaataa atcgtgcaga
      181 ccgggctttt ttaactcaat atttttgtcc tcaagctgca taatttcatc agtaaacagc
      241 accttgccct taaagccgtc aaccaatggc aaaagctctc tgtctgcaat aagaagcttt
      301 gcggaggaat cctcaagcat atacataagt ctgtccttag ggtatgttgg gtcaaggggc
      361 tgatatgccg ccccggcttt aattacgcca aaaggcgcaa tagccataaa ctcgcacctg
      421 ggaataagaa ttgctacaac atcttcccta ccaataccca ttgacaatat atgctttcca
      481 agcctgtcgc ttatttcgtc aagctcttta tatgtatatt tcctgtcttt aaatacaacc
      541 gctgtattgt caggctctgc cttaacaata tcatcaaatg catctgatat tgtcttttgt
      601 ctgtcgtact cactttctgt actgttgaat tgggctattt tattaagtgc attttctgaa
      661 ataattgaaa tttctgaaat atactttgat ttcagcattg aggacattgc cgcctcgtat
      721 gcttcaagaa tttcgtctac gaaagccttg ctgtacatat cactgcgata ttcggctgta
      781 agtacatact cgttgttata atcccttacc tgaataagca gcggcatttt cggcatatcc
      841 agtgaaaggt caatgccgtt agctacagta tcgcctattg ggtaatcgtc actaagctct
      901 gcctgatatg caaaaacaag gtcagaatta agcccgtatt tagcacaaat atctgaaaat
      961 gggaaaatat cattagccat tgacgataca agctgttggg atagcttgct catatatgct
     1021 tgtatagtcg ttttattctc aaacgagcaa taaaccggaa gcgtcttaac aagcatacac
     1081 actgtatttt caagccttga atcatttctg ccgttataaa ttgtagcaaa aaggctgtcg
     1141 tcggaatttg aatatttggt cataagaata ccaaacagac ctgtaaacag ggtatttggt
     1201 gtaaccccaa gcttgtcaca gtaggaaaga attttatttt ccgaaattct tatatgcttc
     1261 tctgtataac ccttttcagg tttatcccct gaattgtcgg gaagcggaag cgactccgtt
     1321 tcaagcccgt caaatatgct gtcaaaatat ttttcggctt ttttatactt gccgtcctta
     1381 atctgctgtt cctcgtcaag tgcggcatca aagcctgtat aggcttcctt ttcaagctct
     1441 tctcctaaat aggatttatt tatatccgca aaaattatat cataggaatt tccgtctgca
     1501 ataatatgat ggaaatctgt aagaagatat tttttgtcct cggttacata aatctcggca
     1561 cggaacaggc ggcttttttc aagcttaaac ggacgaacaa gattattttt gacagaatta
     1621 aattcttcgt ttgtaagcct tataattttc ggtataaact cctcattaca agggctttgc
     1681 accatttcgc cgttatcatc taaaaatacc cttgtaagca ggtaagagtg tgcctttact
     1741 atattggtaa tagcattaga aagcttttct gtatctatat ttgaatccag cttaaacagg
     1801 aaaggaatat tgtatacggt gctgtccgga tttttactgc actctgcaaa tatacccttt
     1861 tgtgagcctg caagaggata tacatctcgt ttttcatatg ttctgatttt cggtgcaagc
     1921 tttatgtaat tctccagctt ttcaaccgta ttattatcgt gaatgtcccc tgttttaatt
     1981 gttacaccaa attcatcgga aagaacaatg caaagcttca ttgcacttac ggaggacaat
     2041 cctgccctgt aaagctcggt atcaattccg aaaaagtcat tgcccacaac ctttgcaaca
     2101 atatcaaaaa tctttttctg catctgtgtt tttggctctt taagattttc aggctgtaca
     2161 acaggctttg gcaacgcctt tttgtcgatt tttccgtttt gcgtcattgg cattttttca
     2221 agctgaataa atacctccgg caccatataa tgtgcaagtg attttgaagc gtaatcaata
     2281 atttcatcag tgccgatttt acggtcagcc gtaaaataac agcaaagata tttattatca
     2341 acaggcactg taacgcttgt cagcacgccg tcaaggctgt ttattacctc ttcaatttca
     2401 cctaattcta ttctaaggcc acgcagctta atctggttgt ctattctgcc aaaaaattct
     2461 atttcgccgt cttcatttat ttttgcaagg tcgcctgttt tatatgctct ctctccgtta
     2521 agctctataa atacggcggc ggttttctca gggagattaa catatcctct gcctacgcct
     2581 aaacctgcaa taacaagctc gccgctttcg ccgtcaggca aaagcttatt atccttatca
     2641 acaatataaa cctttacatt tgaattaggc acgcctatag tgattttgct attgctgtca
     2701 attaccttca ttgtacagct tatagttgct tcggtagggc cgtagccgtt cataatatag
     2761 gcgttagggt ttaccgaacg aagcttatcg taaagtgccg gcggaaatgc ctctgcgcca
     2821 aagtcgaaca cctttatttg cgatatagca gcccttagct gtggcaaatc cactatgttt
     2881 gaaacatatg taggggttgt tgccattaca tccacattgt tttttataat aagctcgcca
     2941 agcataagcg ggtttagaat ttcttcatca cttgctataa ctgctgtaag accgtttgtc
     3001 agcggaataa attcctccat aatagataca tcaaaggtca ttgccgccat tgcaagaacc
     3061 actgttcctc gctctgtaaa ccctaaaagc tcaccgtttt tagggtttgg gtttacaaaa
     3121 ttggcaagat taatatgctc aataataact ccctttggct ttcctgttga gcctgatgta
     3181 tatatgcaat agcaaaggtc atgctccttt atttctacat tcgggtttgc cgtgttctta
     3241 ttttcaagaa gcttatccag aagaagcact tcacatttca gcttagaaaa aagctccttg
     3301 cgtttttctg caatatcgct tgttgtaata acaagcattg cctgcgaatc ttcaaaaata
     3361 tactccactc tgtcatcagg gtaatccgga gccgctacta caaaggcact gccggacttt
     3421 aaaatgccct gtcttacaga gtagaaatcg cagcagcgtt ccagcataac ccctacaagc
     3481 ttttcacggc ctgcaccctt ttcaatcaac gaatttgcaa tcctgtttgc tctttcgtta
     3541 agctgtgtat atgttaggct ttcgccgccg gatataacgg cagttttgtg gggattaagg
     3601 cttacctgct cctcaaaaag cttcgttacc ggtcgaaaat caaagtcaaa ccgtgtatca
     3661 tttattgctg acatttttaa tcactcctaa aaagttatta ttgtgttgtt catatctata
     3721 gcacgaatat aactcataga tttagatatt ttcttaacaa gctctatacc gtgtatatca
     3781 aattcattgc tgtcattttc atagtcaagc ggattaaagt tgataccgtt atcccttatt
     3841 ctaagacgaa gtaaatcacc ctctaggcaa aggctgatat caatccagtt tgaggactta
     3901 cctccaaact taataatatt cactgtcatt tcttcggcac aaacagcggc aaggtttgcc
     3961 ttgctgttag gaatattatt ttctgcacag aagcttataa tttccttatg caccctttgt
     4021 gcttcgtcca ttgtactctg aattgaaaaa tcaaggttta tgcccggatt ttcctttggg
     4081 acaatataga aggatgaatg tttatatttt atctttctga aaatataggc cgcaagtacg
     4141 gttattgctt cggaagcaac aaaaccaacg gcaataccgt ctataccgat tccgtcaaac
     4201 tgcttccata taagtattcc cacaagtgtt gcaggcaaaa ccacaagtgc attctccaaa
     4261 aaagtaacaa ggcttgcaat tgttgttttt tcaatagact cataataact gattataaat
     4321 ttattccaaa gatacggagc aacacagaac gcaaatatac gcagtgaatt taccatttgt
     4381 acgccaagct cgccgccgtc actgccaaac attatagcta tctgctctgt aaatgtcatc
     4441 ataagcacaa acagcacagc aagaactatg tagctgtatt taagcatctt gttacacaaa
     4501 acacaaagtc ccacataatc cttttcgcca taaagtacac cggctacatt cggaataaca
     4561 cctataatgc ctcctacaaa catttccact atcataagaa cattatcgca aacggtaaat
     4621 accgccagac cgtcatcacc aataagattt attataatca tatttattcc cagtgctttt
     4681 acaaagttag tcgccataaa aacaagcatt ggcaagcctg taacaactgc ctcctttata
     4741 attgcaaaat cctttagctt aagccgaaca aagctaatat ttcgcttatc tgaacgagca
     4801 taaaaaacaa atacaaccat tgcaataagg aagcccagaa ctgtagaaag cgacgcaccg
     4861 gctatgccca ttggagtgaa attaagaaat atataatcca atacaaggtt tataacattg
     4921 gcggctatta aataagcaga cgcaagctcg ggatgatttt ctgcaccaag gtagcttatc
     4981 atcattaagc ccacgccaat aaccggagca ccaagcaggc ttataaaaat atagtccctt
     5041 gtatagtaaa ataaaccact gccggaaaca agcattttcg ctgcaggctc ggcaatgaag
     5101 aacgacaggg cagaaaaaat caatccaact aaaacagtaa caacaagagt tgccgaaaaa
     5161 agctttgacg cattttctgt atctcgcttg ccaagcatta tgcctacagc tattgaaccg
     5221 cctatgccaa ggcagtaccc caccagctgg attattgttt caaccggcag gcttgccgta
     5281 atagccgaca tagcgtcaac accgataaaa ttacttacaa aaatagtatc aacaatattc
     5341 ccaagctgca acgcaaggga catcattatt ccggggacaa tgtatttatt aagctttgag
     5401 cttaacagcc ttcggtttct tttttgcata tcgtctcaac tccttattaa atacccacca
     5461 aataatttta cctgtatttt gctcattact gcacaacaaa taattaatta ttcaatatat
     5521 tttgtattct atcacaaata gccgtctgtg tctataatat acatagatat tgcaatattt
     5581 aaaatttgtt gagctgccgc tgcttctttg caccgtatat ataagctttt atagctgaac
     5641 agcgataagt ctatgaatat acctagctga ccgagaacat aattttttgg aaggctgaaa
     5701 gcccttataa gcaaaaaagc tcaccggcta taaatagctg ccgcccctcc tgctaaagct
     5761 aacaatacca taacaccgcc taatacagtt attggtcata ggcattttta gccggcctgc
     5821 tgtagtcgta aattatttct ttttggctgt gcttgcctgt gttgtcatta ttcataaaat
     5881 atttttacct ccgttagtca gcaaaggtca ttccccccta ctttcccata ggtcgggggt
     5941 tttcaggctc tttttagccc taatttctgc gataaacaag ccaaaaatca gggttttcat
     6001 actgcaccat tttgtcgttt ttgaaaaggc agaaatggtg cagttgaggt gctgcctttt
     6061 ttagaatgat tctctttatt ctaaatatat gctgttagaa ccttaaaaga ataataggcg
     6121 ttttttctta cattatttat aagaaaaaaa tagtattatc tgcactgctc ttagtcggca
     6181 ctctctgcct aagcctgcgg aaatttgcac aaagggagcc gtctgtttta agaaaaaaca
     6241 acgcaaatgc tttggctccc tctctcgaca tcctccctca cagaaaaaac agcagaggtt
     6301 ttttcccaca gaatgccata ccctttgatt caaagnnnnn nnnnnnnnnn nnnnnnnnnn
     6361 nnnnnnnnnn nnnnnnnnnn nnnnnnngga tttccctagg ctgtgcttta tgggtaaaat
     6421 tatttaataa gcggattatt tacagcccaa ttgtcagtat gtgtatacac atactatatg
     6481 ctaataaatc aactccggta attatttcca tttaaataaa ttatttattt ttattgttgt
     6541 acaatgtatg tttttatggt aatattaaca cgatatgaag aaactattta taaaaaatta
     6601 atgagcaaat tcctattctt tttgtcggtt tatgctctaa cacaaggagg aaaaaatgga
     6661 aaaacatctg aaacgaaact cttttaaggg ctcatttggc tttgttttgg cagcggccgg
     6721 cagtgcagtg ggcttgggaa atatatggag gttcccttat cttgcgtcta aggacggcgg
     6781 aggtctgttc ctggtgctgt atattatact ggcactaacc tttggcttta cactgctgac
     6841 aactgaaatt gcaataggca gaaaaactaa gcaaagtccc cttacggctt atggtcagct
     6901 caagaaaaag tggaaatggc ttggcgtagt cgcctgctta gtacctgtta ttataatgcc
     6961 atattactgt gtaataggcg gttgggtact gaaatacttc ttagcgtatt taacaggcca
     7021 aggcacagca gtggcagccg acaactactt tacctcgttt attacaagcg atattgagcc
     7081 tatagtaatg ttaatattat ttttgggtgc gtctgccttt gtagtattcc gtggagtaaa
     7141 caagggtata gaatcttttt caaaggttat tatgccggct ttgctgctat tggtagtggc
     7201 aatagctgta ttctcgctta cacttagcca tactgattca aacggtgcta cacgaacagg
     7261 tcttgagggg ttaaaggttt atgttattcc taacctttcg ggccttaccg ttaaaagctt
     7321 tttctcaaca ctgcttgacg caatgggaca gcttttcttt agcttaagcg tcgctatggg
     7381 tattatgatt gcctacggct catatgtgcg tgacgatgct aaccttaata aatcaattaa
     7441 ccaaatagaa atatttgaca cagttgttgc atttttagcc ggagttatga ttattcctgc
     7501 tgtgtacaca ttctcgggca ttgagggtat ggacgcatca ggtccaagcc tgatgtttat
     7561 atctctgcca aaggtatttg ccgcaatggg ctttgtcggc aacattattg gctgtttgtt
     7621 ctttgcaatg gtgttatttg cagccctaac aagtgctgta tctgttatgg aggctgtagt
     7681 gtcaagccta atggataact ttaagctgtc cagagtaaag tcggcaagta tagagggcat
     7741 aattgccttg gttgttggaa ttttggtatg cttaggctac aatataatgt attttgaggc
     7801 gtcgctgcca aacggagcaa ccggtcagct gttggatata atggactatg taagcaacaa
     7861 cattcttatg ccaatagtag ctataggcac ctgcgtatta atcggttgga tagttaagcc
     7921 taaaaccgtt attgacgagg tggaaaaaaa cggcaataaa atgggcagga aaaggctcta
     7981 cactgtaatg attaaatttg ttgctccggc aatgcttgtg ttgcttttct taaaatcagt
     8041 aggaatatta acagtaatat aaaatggaag attttaaaaa cggactaaaa aacggtatcc
     8101 ccattgcgtt ggggtacctg tcggtatcat ttacctttgg acttcaggct gtaaacggcg
     8161 gtatgagttg gtggcaggct gtattaattt cccttacaaa tgttacctcg gcaggtcagt
     8221 ttgcaggact tgacataatg acggcagggg caggactttg gtttgaaatg gcatgcacac
     8281 aatttataat caatatacgc tattccctta tgtccctctc cctttcacaa aagaccgacc
     8341 cctcaattag agggatacat agatttttaa ttgcctttgg cataacagat gaaatttttg
     8401 cagtagctat gggctcacca aatgatgtaa gcaatacata tatgtacggc ttaataagcc
     8461 tgccggtgct tggctggtgc agcggtacac tgcttggcgc tgcggcaggt cagctgctgc
     8521 ccgaaattat acgcagtgca cttaatatag caatatatgg tatgtttata gctataatac
     8581 ttccgccggc acgaaaaaac aaagcaatta tggctgtggt aattatttct gttttgctaa
     8641 gctgctgctt caagtggctg cctcttttaa acagtgtttc aggcggcttt gttataataa
     8701 tatgtgcagt tatagccgca gtggcagggg caatattctt ccctgttaag gaggagaaag
     8761 ccgatggaaa ttaaaagctt ttttatctac cttataatta tggccggcgt tacatacctc
     8821 ataagaatgc tgccgtttgt aatttttaaa ggtaaaataa ccaatacatt tatcaaaagc
     8881 tttctctact acattcccta tgccgtactg ggagcaatga cctttccggc tataattttt
     8941 tctaccggaa attattcatc ggctgttgcc ggactaatag ttgcctgcgt attggcattc
     9001 agagaaaaaa gcttacttac cgtagcggtc tttgcctgca tagccgcact tgcggtgaat
     9061 attatatgcc tgtatattta gacttttttg tagtaaattg tagtaataat tattgtcaat
     9121 gttgaaggct tgtcccttac accggaggca gaaaaatgta ccactgcaat ttctgaaaca
     9181 agagatggtc tgtataagaa ttataacagg ctcaaaggca gatcttgatt cttatatggt
     9241 atgattagac acaggctcgg cggataaggt tggataaaaa tataaatttc ttataatact
     9301 taagaccaac aaaaaatgca gagcatacac ttcagacagc taaaagtccg gagtgtatgc
     9361 tctgcttcat tgttaaggtg gttacatttt aggtattcgg attaagggtt aagtaactta
     9421 aaagttccag tcatccggag cttttaattt tttgtttatt ggttctttcc cctctttgac
     9481 atcggttacc tcgcttttag gcaccttgcc ctcaaacaaa tatctgtcta cttgttcaaa
     9541 tccattctcc tttgtaaaca actgctcacc ctctgaaaca aatcctgaag ttataacata
     9601 ctctgtatcc gtttcacgaa ttacgccaac ttgccgtccc ttatactttc cgacattata
     9661 tatgttgcaa aaccattcaa catcttcttt aagtacctcc ttaatgtatt tcccaacatc
     9721 actaaatttg tttttaccat aataaggatt tttttcaaaa ccgttttttt ctaaatcctc
     9781 tatgtcgtgt gaccgtaaca aagcctctgt aggccccaga gaacaactat atattttccc
     9841 tctgtactta caataatatc ctgttcttag catcatttat caatctccta actttttata
     9901 acattttgaa gcatagttaa atactgtaat tataaatata acatttatta tgcaatattt
     9961 ccacactata tactaattta ttaaatatat ttgtgtaaaa caaaagcaga gtatacactc
    10021 cggactttta actgtcttcc gaaggtatgc tctgcttcat tgttaaagtg g
//
