LOCUS       c00124_3300029..       15612 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  3300029906.a:Ga0247342_1001640.
ACCESSION   c00124_3300029..
VERSION     c00124_3300029..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 5.1.0
            Run date     :: 2019-11-24 05:13:34
            Original ID  :: 3300029906.a:Ga0247342_1001640
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15612
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15612
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[13119:14334](+)"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      13120..14334
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..15612
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15612
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(2..1390)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264:diaminopimelate decarboxylase (Score: 86.7;
                     E-value: 1.7e-26)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg124_1"
                     /transl_table=11
                     /translation="MLEAQELAKNRALQQWRVEDSIELYGIRNWGAGFFTVSDEGDVVV
                     CPQGPKGPQISIPEIISGLRERGYDMPVLLRVENILDSRIASLHESFRKAIKNLNYQGE
                     YRGVFPIKVNQQQQVVEKIAQFGSRYHHGLEVGSKAELIAAVSLMRDTEACIVCNGYKD
                     EEFIDLGLQAQRLGFNLFFVLEMPSELDVLLSRSRELGIRPNIGVRAKLSVKASGHWTD
                     SGGERSTFGLSPAQIVDVVDKLKACDMLDCFRLLHYHLGSQVSNIRDIRTGVMEGARLY
                     VGLVQEGAPMGYLDLGGGLAVDYDGSHTNYISSRNYNLDEYSADIVEAIMSILDEQQVP
                     HPHIITESGRATVAYYSVLLFNVLDVSAVEEAQLPAELPEDTPEPVLNMREVYGNISLR
                     NLQECYNDAIYYRDEMRKLFSTGRVNLRQRTLSERFFWAIIMRIAQEKVKLKTVPRDLQ
                     DIDVS"
     CDS             1601..2683
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 231.9; E-value:
                     1.7e-70)"
                     /gene_kind="transport"
                     /locus_tag="ctg124_2"
                     /transl_table=11
                     /translation="MKHLAIFLLLLVPVLASCSGDKDGQGGRQAAPVHVMTVQPQDVPR
                     VLGAVGNVKASASVGLTPRVTGEIEKVHFTEGQDVKEGDVLLTIDTRPFEATLREKKGQ
                     LAKSEAQLHKATNDAGRYGKLVGNGYVSREAYEQTATEAAALRATVQADKAAVESAALD
                     LSYCTLRAPISGRVGGLKVDKGNMVRSSDTTPIVSIDTLSPIYVTFSVPERHLSLILDR
                     MHAGPVEVDVTPTGGQTEKGLLTLVENSVDTTTGTIQLRATFDNENRRLWPGQFVTVEL
                     PLGMARQALAIPSRAVQSGREENYLYVAGADGKASYRKVNILFESGDISVVEGELKAGE
                     QVIIDGIVRLAPDVPVKVIQ"
     CDS             complement(2963..3592)
                     /locus_tag="ctg124_3"
                     /transl_table=11
                     /translation="MSRFPIPAADAAAPFQTEIIIRRSRFLTHCAHTPGMEAARAFVEQ
                     IRTKHADATHNCWAFVAGAPGHSGQVGFSDDGEPHGTAGRPMLQVLLHCGVGEITMVVT
                     RWFGGVKLGTGGLVRAYQDSVRENLATLPLAEKVPTVELDVQLDYAHLDRLHRLLPTFE
                     ARVCAEAYDQAARVRICLPEALRGPFEEAIAGRTDGRARCTPVEEA"
     CDS             complement(3589..4158)
                     /locus_tag="ctg124_4"
                     /transl_table=11
                     /translation="MTATTSLAQALSAQDIIRHYDLMPHVEGGHYRRVWCSSQDLQPES
                     LPCGIYGSRPCSTSILYLLQAGERSRLHRIRQDELWHFHLGGPLRLYCLTPDGKELDRI
                     LGADILAGQHLLLPMPGGCWFGAEPCPGTDFSLVSCTVAPGFDFRDFELAKAACLVRRY
                     PFAKEGIEHFCRLPDGCPDPGKGCRE"
     misc_feature    complement(3919..3921)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             4417..4929
                     /locus_tag="ctg124_5"
                     /transl_table=11
                     /translation="MSKTLENLMAAFAGESQANRKYLAYAQAADKEGLSGVAKVFRAAA
                     AAETIHAHTHLKNAGKIGDTAANLQDAIGGETYEFTKMYPEMIKEAEAEGQTAVAKYMD
                     MVNKVEEVHANLYKKAAADNHAFDNVDFYVCKVCGYTHEGPCDSCPVCGAKAAAFFKVD
                     DACCLNK"
     CDS             complement(5161..5649)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 61.1; E-value:
                     1.6e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg124_6"
                     /transl_table=11
                     /translation="VRELSNALQKALVFNSGAPVSIRDLQLVLDSPAAHPPAAGLSING
                     NGDTGPAPGVRRSPVGTGNGFHEGETPVEDAPAPAGVPHNDEQRSLASIVTACLRSGDP
                     SPFDTCMDIMGRAVVREALRQCRGNRSQAARLLGLSRPTLLARMEKYGLKIETRISDE"
     CDS             complement(6718..7800)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 170.9; E-value: 1e-51)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg124_7"
                     /transl_table=11
                     /translation="MNENPSQPVQDASAPGEKNGFDLTRLLLPGSIVLALCLLLCIWLC
                     IDIFIWPLGTRQRILMCLLLFALLLLLGLGACLWRGIYLPLLTALRELGPDADGRMPXX
                     XXXXXXXXLEESHENLRQNLRQTEKMALVGKLAAGVAHSIRNPLTGLKLRLFSFTRGME
                     LSPAQQEDVQAMNEAVRHMEAITSNFLEFSRRPRLSKEPLDMSEVLDRTLILLQPRMEA
                     YKVTLRRTRHAPLPRVDGDAEQLREALANLIINACEAAGTDGEVRISEERGRLAPLGPV
                     VVIRIEDSGPGVPEELHEVIFQPFMSTKVEGTGLGLPIARRIFEEHGGWLHLHNAPGHG
                     ASFVMVLPVRKGDDVWLRSS"
     CDS             complement(7879..8868)
                     /locus_tag="ctg124_8"
                     /transl_table=11
                     /translation="MNIICPQCGFSRPFPPDRAPAHSVIATCPQCSCRFRFHPQDGSSE
                     QLSPVRNDAAPAASDLPPGAIIPGMGDDGEGGASCRREDPREEIPPFRPRDRQEEPGQQ
                     TDDEPLEDDFRDDDADDDRPGLPSGNPWDVAPAPSGWMVAFYRTATRIMFGAPAFFSCL
                     RPHRRSLRALSFYLIVSVILSVVQLLWMRGMTSMLVDGGMDPQMQQMMASTLAIHESMP
                     LFVLKQVAFVTLQLYVQSALLYLMYRLILRDKPEFDLIFQVSAYGSAPMLLCVIPVLGA
                     LTGLVWSLACTLVGYKTVLRLDWSQTLLGYAPVFLLEMFLLLQVMQML"
     CDS             9149..10390
                     /locus_tag="ctg124_9"
                     /transl_table=11
                     /translation="MSLRDLRPYLLAILMTLPGLALRLAPADVSPMLVAVLAGLAILGA
                     SFLLTWACEVAQLDIPQAVAVAVVAFIAVLPEYAVDMYFTWMAGQHPESAYSHYAIANM
                     TGANRLLIGIGWTAIVLIFAGRFHNYVALHEEKRTDILFLGMATLYALLIPLKGSLTLF
                     DGVVFLGIYVAYMCIIARRPCEEEEPEGPAATLAKLSRPARMRAVAGLFLFAALVILFN
                     AEPFSESLVASGKILGINEFLLVQWLAPIASEAPEFIVALMFAFRGNAGLALGSLLSSK
                     LNQWTLLVGMIPGVYAVSSGGTTPINLDPHQFQEIFLTAGQSIFAVALLLDLRLGLREA
                     AALLVFFLAQLFSPFYDVQLEALLGLPHDPLRLHNFYAWTYLILAGLLLLRHWRLVAEL
                     RYGFHVKVRDIVHH"
     CDS             10625..11380
                     /locus_tag="ctg124_10"
                     /transl_table=11
                     /translation="MLALAALLSCFALSPDLCPTASAAHGHGTMLADSRPEPALAPISV
                     TDCNLRRVSRPGKPDITVTYPMLGRKDVDRDVADWVERIASTFEAELAPLALEWQEQEL
                     PPCELIGSYTLTRPSANALSIVFEIWTYTGGAHGNLDVIPLTYSLLSGQRLGLVDIFEN
                     VDKALEIMSAVSRKELATRLGGGRVDSMIHDGTEPLADNFSALALVPGGVRVYFQPYQV
                     APWAAGTQRVFIPLEKLAPAGPLHLLWGE"
     CDS             11377..11691
                     /locus_tag="ctg124_11"
                     /transl_table=11
                     /translation="MMPPLEAVLRFPGHAPLLADHFPGAPRVPGSCLLEAMRRAVEEAF
                     PSRRVRAVRRARFRHFVLPDSDLLCRMEPEDRGDALPSEVRCRLLHGDACLAEAVFSLE
                     "
     CDS             11994..12722
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     86.8; E-value: 2.7e-26)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg124_12"
                     /transl_table=11
                     /translation="MRLTFHGSVLILGGSSELGRALALALRAEGAQVCCVCRDDAGCAR
                     CAQDGLPALVLGDPETLPARCEALLGRPVGHLADLLHSRFEQLVAMAAPEAIERWADDD
                     IALRARCLRAVSRAMLARRFGRCVFVSSSAAQRPSPGQGWYAAAKLAGEGLYRSLGVEL
                     AGRGLSACSARLSWLDAGRGHEFLSRHGQVARAMPAGRCLGPDDVLPGLCFLLSAEAAA
                     INGSVVTLDGGLGALKLPEL"
     CDS             12722..13120
                     /locus_tag="ctg124_13"
                     /transl_table=11
                     /translation="MRYDEISLKVREIVANLFERDAATLSDDTLLMQDLPCESIDLLEV
                     SVQLGATFHIFVDEERAFLRSLRYQLAGAPDAAAFLREHYGHLDEARRQQLAAYYTDAD
                     GMALQSPLTLGDIAHWVEQALEATRQGA"
     CDS             13120..14334
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (134-400). E-value:
                     1e-35. Score: 115.2. Matches aSDomain:
                     nrpspksdomains_ctg124_14_PKS_KS.1"
                     /NRPS_PKS="type: PKS/NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 243; E-value:
                     1e-73)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg124_14"
                     /sec_met_domain="APE_KS1 (E-value: 6.6e-66, bitscore:
                     212.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVPERVVISGAGCCTALGHDLDSVARSLREGRDAFRASGALEGL
                     SVCPAEDWGQDEARQQFEGWRHRHYLNRGSRMAVLSGLRALRDAGLEAGLPVRSQIIAA
                     VGPMLDVTGEPGLPPQDTATLGALWLLRWLPNTAAGALARFARCHGEALTVNAACASAL
                     QALGEGWRRIRFGLADAVLVAAGDSRLSLGGLLGYHKARALSLCAPGTGPRPFDMGRDG
                     FVPGEGGAAFVLESLSSAQARGAHVHAEILGYGASVDAESLTAPEARGTWAELAVRGAL
                     EEAGLDAAGLGWLSAHGTGTQLNDQAESLLWERLLGDVPGGPAVMAFKSWLGHGSSACG
                     ALELCCALAAWRDGRMPPVRHLERPCSPRLDFVREPRPFPSSRGLLENFGFGGQNAALA
                     VDLRP"
     aSDomain        13522..14319
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg124_14_PKS_KS.1"
                     /evalue="1.00E-35"
                     /label="ctg124_14_PKS_KS.1"
                     /locus_tag="ctg124_14"
                     /protein_end="400"
                     /protein_start="134"
                     /score="115.2"
                     /tool="antismash"
                     /translation="PNTAAGALARFARCHGEALTVNAACASALQALGEGWRRIRFGLAD
                     AVLVAAGDSRLSLGGLLGYHKARALSLCAPGTGPRPFDMGRDGFVPGEGGAAFVLESLS
                     SAQARGAHVHAEILGYGASVDAESLTAPEARGTWAELAVRGALEEAGLDAAGLGWLSAH
                     GTGTQLNDQAESLLWERLLGDVPGGPAVMAFKSWLGHGSSACGALELCCALAAWRDGRM
                     PPVRHLERPCSPRLDFVREPRPFPSSRGLLENFGFGGQNAALAVD"
     aSModule        13522..14319
                     /domains="nrpspksdomains_ctg124_14_PKS_KS.1"
                     /incomplete
                     /iterative
                     /locus_tags="ctg124_14"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       13567..13614
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg124_14_0001"
                     /evalue="3.20E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="ctg124_14"
                     /protein_end="165"
                     /protein_start="149"
                     /score="10.2"
                     /tool="antismash"
                     /translation="GEALTVNAACASALQAL"
     CDS             14331..14804
                     /locus_tag="ctg124_15"
                     /transl_table=11
                     /translation="MNTDFFLDAPSPFVLLDAARAMDSPPGLTAWRRCEGVPFWQVLEA
                     AAQAAALQQRVARDFSCHAFLLSVERAPWPAGPLSGTARLDVRVTAQGGSVAASLVRVR
                     GLCGPGGPLPPLELELRVGLVPYDASFSRELLESRYRELYSCLSHNAEAFMTV"
     CDS             14765..15610
                     /NRPS_PKS="Domain: Aminotran_1_2 (79-268). E-value:
                     7.8e-27. Score: 86.0. Matches aSDomain:
                     nrpspksdomains_ctg124_16_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109:8-amino-7-oxononanoate synthase (Score: 208.4;
                     E-value: 2.5e-63)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg124_16"
                     /transl_table=11
                     /translation="MSVPQRRSLYDCLNDRLRADARLGLARDSAAMAGGAAGPLLYRDG
                     REYISFMSNDGLGLAADAHWQARVAACFAAHAPSASASRLAGGRSDVVDQACRAVADYF
                     GFAECLFLPSGYQANLACVTTLLQQGQEAFVDRRCHASVMRALPLAGARIRAWNHLDYD
                     HLERLLSSLPLDAPQPVVMAESLYSMDGAALDLERMAALRRRYGFFLCVDEAHALGALG
                     PGGRGLCAAQALRDGGRAPADLVVGTLGKSLGLWGAFLLLPRGFTPLFEHLASAIMHST
                     A"
     aSDomain        15002..15568
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg124_16_Aminotran_1_2.1"
                     /evalue="7.80E-27"
                     /label="ctg124_16_Aminotran_1_2.1"
                     /locus_tag="ctg124_16"
                     /protein_end="268"
                     /protein_start="79"
                     /score="86.0"
                     /tool="antismash"
                     /translation="ASASRLAGGRSDVVDQACRAVADYFGFAECLFLPSGYQANLACVT
                     TLLQQGQEAFVDRRCHASVMRALPLAGARIRAWNHLDYDHLERLLSSLPLDAPQPVVMA
                     ESLYSMDGAALDLERMAALRRRYGFFLCVDEAHALGALGPGGRGLCAAQALRDGGRAPA
                     DLVVGTLGKSLGLWGAFLLLPRGFTPL"
ORIGIN
        1 ggctcacgtc gatgtcctgc aggtcgcggg gcacggtctt gagcttcacc ttttcctggg
       61 cgatgcgcat gatgatggcc cagaagaaac gctccgaaag ggtacgctgg cgcaggttca
      121 cgcggcccgt ggagaagagc ttgcgcatct cgtcacggta gtagatggcg tcgttgtagc
      181 attcctgcag gttgcgcagg ctgatgttgc cgtagacctc gcgcatgttc agcacgggct
      241 cgggggtgtc ttcgggcagc tcggcgggca gctgggcctc ttccacggcg ctcacgtcca
      301 gcacgttgaa cagcagcacg gaatagtagg ccacggtggc gcggccggat tcggtgatga
      361 tgtgcgggtg cggcacctgc tgctcgtcga ggatgctcat gatggcttcc acgatgtcgg
      421 cgctgtattc gtccagattg tagttgcgcg acgagatgta attggtgtgc gagccgtcgt
      481 agtccacggc cagaccgccg cccaggtcaa ggtagcccat gggcgcgcct tcctgcacca
      541 ggcccacata aaggcgcgcg ccttccatga cgccggtgcg gatgtcgcgg atgttggaga
      601 cctgagagcc caggtggtag tgcagcaggc ggaagcagtc cagcatgtcg caggccttga
      661 gcttgtccac cacgtccacg atctgggccg gggaaaggcc gaaggtggag cgctcgccgc
      721 cggagtcggt ccagtggccg ctggccttga ccgagagctt ggcgcgcacg ccgatgttgg
      781 ggcggatgcc cagttcacgg ctgcgggaga gcagaacgtc cagttcgctg ggcatctcca
      841 acacgaagaa caggttgaag cccaggcgct gggcctgcag gcccaggtcg atgaactcct
      901 catccttgta gccgttgcag acgatgcagg cttcggtatc gcgcatcagg gagacggcgg
      961 cgatgagctc cgccttggag cccacttcca gaccgtgatg gtagcgggag ccgaactggg
     1021 cgatcttttc caccacctgt tgctgctggt tgaccttgat ggggaagacg ccgcggtact
     1081 cgccctgata gttcaggttc ttgatggcct tgcggaagga ctcgtgcagg ctggcgatac
     1141 gggagtccag gatgttttcc acgcgcagca gcacgggcat gtcatagccg cgttcacgca
     1201 agccggagat gatctccggt atggagatct gcgggccctt tgggccctgc gggcagacga
     1261 ccacgtcccc ttcatcggac accgtaaaaa agccggctcc ccagttgcgg ataccgtaca
     1321 gttcgatgga atcttccacc cgccactgtt gcaatgcgcg gttttttgcc aattcttgtg
     1381 cctccagcat cggaaatttc ggatgagttc gcgggctctc ccgccgcggg attattatgc
     1441 ccgcacaggg gggaaagtca attgtcccgg ggccgctgtc cgtccgggaa ggcagggagg
     1501 gcaagcgctc ccgggcagga ccacacattt gttttcttga cgcgatgtgt ctggtgtgca
     1561 acgtttttga ggcatcattc agaaaatcgt gaggactgcc atgaaacatc ttgccatctt
     1621 cctgctgctg ctcgtccccg tgctggcctc ctgttccggc gacaaggacg gacagggcgg
     1681 cagacaggcc gcgcccgtgc atgtgatgac ggtacagccg caggacgtgc cgcgcgtgct
     1741 cggcgctgtg ggcaacgtca aggcttccgc cagtgtgggg ctcactcccc gtgtgaccgg
     1801 cgagatagaa aaggtccatt ttacggaagg ccaggacgtg aaggaaggcg atgtgctgct
     1861 gaccatcgat acgcgtccct ttgaagccac cctgcgcgaa aagaagggcc agctggccaa
     1921 gtccgaggcc cagctgcaca aggccaccaa cgatgcgggc cgttacggca agctggtggg
     1981 caacggctat gtgagccgcg aggcctacga acagaccgcc accgaggccg cggccctgcg
     2041 cgccaccgtg caggccgaca aggccgcggt ggaaagcgcc gccctcgacc tttcctactg
     2101 caccctgcgc gcgcccatca gcggccgtgt gggcggtctc aaggtggaca agggcaatat
     2161 ggtgcgcagc tccgatacca cccccatcgt cagcatcgac accctttcgc ccatatatgt
     2221 gaccttttcg gttccggagc ggcatctttc cctgatcctc gaccgcatgc atgccggacc
     2281 tgtggaagtg gacgtgaccc ccacgggcgg gcagaccgaa aagggcctgc tgaccctggt
     2341 ggaaaacagc gtggatacca ccaccggcac catccagctg cgtgccacct tcgacaatga
     2401 gaaccgtcgc ctctggcccg gccagttcgt gaccgtggaa ctgccgctgg gcatggcgcg
     2461 ccaggccctg gccatcccca gccgggccgt gcagagcggc cgtgaggaaa attacctcta
     2521 tgtggccggt gccgacggca aggcctctta ccgcaaggtg aacatcctct ttgagtctgg
     2581 cgacatcagc gtggtggaag gcgagctcaa ggccggggaa caggtcatca tcgacggtat
     2641 cgtgcgcctg gctcccgatg tgccggtgaa ggtgatacag taaggacgct gccgggggag
     2701 aacggatctc ctcccgccga gtttgaagaa tggacgagcc ccgtctgccg gacagcaggc
     2761 ggggcttatt tttatatcgg ggggatccgt atcccggtcg gggactgctg gccatcttcc
     2821 cctggaaggg gcgtgcctga aaaggcggac gggcctgcgc ctgccggatg cgcgggccgg
     2881 ctcgggcggg aagccttctt gtggatatgc cggagacgct ttgaggggga cggcaagacg
     2941 tgtcttgcgg cagccccctg cctcacgctt cctcgaccgg cgtacagcgg gcgcggccgt
     3001 cggtacgtcc ggcgatggct tcctcgaagg ggccgcgcag ggcctcgggc aggcagatgc
     3061 gtacccgggc ggcctgatcg taggcctcgg cgcagacgcg ggcctcgaag gtgggcagca
     3121 ggcggtgcag gcggtccaga tgggcatagt ccagctgcac gtccagctcc acggtaggca
     3181 ctttttcagc cagcggcagg gtggccaggt tctcgcgcac cgaatcctga taggcgcgca
     3241 ccaggccgcc ggtacccagt ttgacgccgc cgaaccagcg cgtgaccacc atggtgatct
     3301 cgcccacgcc gcaatgcagc agcacctgca gcatggggcg cccggccgtg ccgtgcggtt
     3361 cgccgtcatc cgagaagccc acctggccgc tgtgtcccgg agccccggcc acgaaagccc
     3421 agcagttgtg ggtggcgtcg gcgtgtttgg tgcggatctg ctccacgaag gcgcgggcgg
     3481 cttccatgcc gggcgtatgc gcgcagtggg tcaaaaaacg gctgcgccgg atgatgatct
     3541 cggtctggaa gggggcggcg gcatcggccg cggggatggg gaagcggctc attcccggca
     3601 gcctttcccg ggatcgggac agccgtcagg cagccggcaa aaatgttcga tgccttcttt
     3661 ggcaaaagga tagcggcgta ccagacaggc cgccttggcc agctcgaagt cacgaaaatc
     3721 gaagcccggc gccaccgtac aggagaccag ggaaaaatcc gtccccgggc agggttcggc
     3781 gccgaaccag cagccgccgg gcatgggcag cagcagatgc tggccggcca ggatgtcggc
     3841 ccccagtatc ctgtccagct ccttgccgtc aggggtcagg cagtacaggc gcaaagggcc
     3901 gcccagatgg aaatgccata actcatcctg gcggatgcgg tgcaggcgtg agcgctcgcc
     3961 cgcctgcaac agatacagga tgctcgtgct gcacgggcgg ctgccgtaaa tgccgcaggg
     4021 aaggctctcg ggctgcagat cctgcgagct gcaccagacg cgccggtagt ggccgccttc
     4081 cacgtggggc atcaggtcat aatggcggat gatgtcctgg gccgaaaggg cttgtgcaag
     4141 ggatgtggtc gctgtcatgc cgttttttta gcctgccttg gcccggctcg caagctttgc
     4201 ggacagggca tggaacaaag ggcgtttttg tgcaggaaag acggtgctaa tccggctccg
     4261 ggacattgac gcgggccatt cgggccttat ttattggggg cggaaataaa aatacgcaaa
     4321 aaaatgcttt acaaaggcat gagttttctg taaacaggaa tcgttcctga ttaagacaac
     4381 acttttttga acatataccc cccaaggaga accacaatga gcaagactct cgaaaacctg
     4441 atggctgctt tcgccggtga atcccaggcc aaccgcaaat acctcgccta cgcccaggct
     4501 gccgacaagg aaggcctgtc cggtgtggcc aaggtgttcc gcgccgctgc cgccgccgaa
     4561 accatccacg cccacaccca tctgaagaac gccggcaaga tcggcgacac cgccgccaac
     4621 ctgcaggacg ccatcggtgg tgagacctac gaattcacca agatgtatcc tgaaatgatc
     4681 aaggaagccg aagccgaagg ccagaccgcc gtggccaagt acatggacat ggtgaacaag
     4741 gtggaagaag tgcacgccaa cctgtacaag aaggctgccg ctgacaacca cgctttcgac
     4801 aacgtcgact tctacgtctg caaggtctgc ggctacaccc acgaaggccc ctgtgacagc
     4861 tgccccgtgt gtggcgccaa ggccgctgcc ttcttcaagg tggacgacgc ctgctgcctg
     4921 aacaagtaag ttcggccggt cctgactttt ccaggcgctg cccttcgggg cggcgccttt
     4981 ttttgtgccc gttggccggg aaagatggcc ttgccatgcc gcaaaaccgt gcggcggggg
     5041 aaggtgccgt caccgggcgg gccgtttggg ctgtgcctgg gggctgcggc gcggcggccc
     5101 ccagcaggcc ctgggatagc gcgggcattg aagcggtgac gggcgtttgc cccgcggccc
     5161 tcattcgtcg ctgatgcggg tctcgatctt caggccgtat ttttccatgc gcgccagcag
     5221 ggtggggcgg gaaaggccca gcaggcgggc cgcctgcgag cggttgcccc ggcactggcg
     5281 cagggcctcg cgcaccacgg ccctgcccat gatgtccatg caggtgtcga agggcgaagg
     5341 atcgccggac cggaggcagg ccgtgacgat gctggccagg ctgcgctgtt cgtcgttgtg
     5401 aggtacgcca gcaggagccg gggcgtcttc gacaggagtt tccccttcgt ggaagccgtt
     5461 cccggtgccg acgggggagc ggcgtacgcc cggggcaggg ccggtatcgc cgttgccgtt
     5521 gatgctgagg cccgccgcgg ggggatgcgc tgccggggaa tccagcacca gctgcaggtc
     5581 gcggatgctc accggggcgc cgctgttgaa gaccagggcc ttctgcaggg cattggaaag
     5641 ttcgcgcacg ttgccgggcc agtccagacc ggccagatag cgcagggcct cttcttccag
     5701 accgggatcg ggccgnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5821 nnnnnnnnnn nnagtacagg tcctcgcgga agcgcccgtc ggccacggcc tgctccagat
     5881 tggcgttggt ggcggcgatg atgcgcacgt ccacgtcgat ggagtcatgc ccgcccagac
     5941 gctggatctg tttttcctgc agcaggcgca gcagtttggc ctggatgccc ggcggcatgt
     6001 cgccgatctc gtccaggaag atggtgccgc ccgcggcctg ttcgatacgg ccgatgcggc
     6061 ggtgctgcgc gccggtgaag gcaccgcgtt cataaccgaa aagttcgctc tccagcaggg
     6121 tgtcggggat ggccacgcag ttgatgaccg agaacggacg gcgggagcgc ggactgtagc
     6181 gccagatggc attggccacc agctccttgc ccgtgccgga ttcgccccgg atcagcacca
     6241 gggcatcggt gggcgccacg cggccgatgg ccttgtacag ctcctgcatg gggggcgtat
     6301 gtcccaccag gcggatgtcg tcctcttcgc ccagagcctc ctcggcggac tgggcctcgt
     6361 ggcggcgctg gctctctccc gcggccaggg cccgttgcag cagctccagc acctgcggga
     6421 tgtcgaaggg cttgagcatg tagtcgaagg cccccagccg ggtggcttcg atggcggtct
     6481 cggtggtgga ataggccgtc atgatgacca ccggcggaca gccctccagg gcacgcatcc
     6541 gcttgagcgc ttccagaccg tccatgccgg gcatgcgcac gtccatgacc acgcattgcg
     6601 gcatcttttc ccgcatgagg ttcagggcct cctcggccga ggcggcggtg cgcgtctcgt
     6661 agccttcggc gtccagcagg cgctggaagc cctgacgcag gtggtggtcg tcgtcgacta
     6721 tgaggatctc agccatacgt cgtccccctt gcggacaggc agtaccatga cgaagctggc
     6781 cccgtgtccc ggtgcgttgt gcaggtgcag ccagccgccg tgttcttcaa agatgcgccg
     6841 ggcgatgggc aggcccaggc ccgtgccctc caccttggtg ctcatgaagg gctggaagat
     6901 gacctcgtgc agctcttcgg gcacgccggg gccgctgtcc tcgatgcgga tgaccaccac
     6961 gggccccagc ggggccaggc ggccgcgctc ttcgctgatg cgcacttccc cgtcggtacc
     7021 ggcggcttcg caggcattga tgatgaggtt ggccagagcc tcgcgcagct gttcggcatc
     7081 gccgtccacc cggggcaggg gcgcgtgccg cgtgcggcgc agggtcacct tgtaggcttc
     7141 catgcgcggt tgcagcagga tgagggtacg gtccagcacc tcgctcatgt ccagcggctc
     7201 cttgctcagg cgcggacggc gcgaaaattc cagaaaattg ctggtgatgg cttccatgtg
     7261 ccgcacggcc tcgttcatgg cctgcacatc ttcctgctgg gccggggaaa gctccatgcc
     7321 ccgggtgaag gagaacaggc gcagcttgag gcccgtcagc gggttgcgga tggagtgggc
     7381 caccccggcg gccagtttgc ccaccagggc catcttttcg gtctggcgca ggttttggcg
     7441 caggttctcg tggctttcct caagnnnnnn nnnnnnnnnn nnnnnnnnnn nntgcggcat
     7501 gcgtccgtcg gcatcggggc ccagttcgcg cagggccgtg agcaggggca ggtagatgcc
     7561 gcgccacagg caggcgccca ggcccagcag caggagcagg gcaaacagca gcaggcacat
     7621 gaggatgcgc tggcgcgtgc ccagcggcca gatgaagatg tcgatgcaca gccagatgca
     7681 gagcagcagg cacagggcca ggacgatgct tcccggcagc agcagccggg tgaggtcgaa
     7741 accgtttttt tctccaggag cggaagcgtc ctgaacgggc tgggaagggt tttcgttcat
     7801 gggtggcacg ggcggagggg gaaaaggccc gcgctggcgg cagcggcggg cccggaaaac
     7861 gttagggtcg gtacagggct agagcatctg catcacctgc aggagcagga acatctccag
     7921 caggaaaacg ggcgcgtagc ccagcaacgt ctggctccag tccaggcgca gcacggtctt
     7981 gtagcccaca agggtgcagg ccaggctcca gaccaggccg gtgagcgccc ccagcacggg
     8041 gatgacgcac agcagcatgg gcgccgagcc ataggcgctg acctggaaga tcaggtcgaa
     8101 ttccggtttg tcgcgcagga tgagccggta catgagatag agcagggcgc tttgcacata
     8161 caattgcagg gtcacgaagg ccacctgctt gagcacgaac aggggcatgc tctcatggat
     8221 ggccagggtg ctggccatca tctgctgcat ctgcgggtcc atgccgccgt ccacgagcat
     8281 ggaggtcatg ccgcgcatcc agagcagctg caccacggaa aggatgacgc tgacgatcag
     8341 gtagaaactc agggcgcgca gggagcggcg atgcgggcgc aggcagctga agaaggccgg
     8401 cgcgccgaac atgatgcgcg tggccgtgcg gtaaaaggcc accatccagc ccgaaggcgc
     8461 aggcgccacg tcccaggggt tgccggaagg caggccgggg cggtcgtcat cggcgtcgtc
     8521 gtcccggaag tcgtcttcaa gcggctcgtc gtccgtctgc tgcccaggct cttcctgccg
     8581 gtcacggggc cggaagggcg ggatctcctc gcggggatct tcgcggcggc aggaggcccc
     8641 gccttccccg tcatccccca tgccggggat gatggcgccg gggggcaggt cgctggccgc
     8701 cggggcggcg tcattgcgga cgggcgaaag ctgctcgctg ctgccatcct ggggatggaa
     8761 gcggaagcgg caggaacact gggggcaggt ggcgatcacc gaatgcgccg gagcgcgatc
     8821 gggagggaaa ggacggctga aaccgcattg agggcagatg atgttcatga cgctactcat
     8881 agcagagagg catctgccct gcaatccggg gaacggccac ggggaggaaa aaggcggatt
     8941 caggcttgac aggcggggag agagcaacta ttttatccgc acctaagggg agtaactggg
     9001 tccttgagac cctggcagca tcaacagcct gacatcacgt ctggtgctgc cgttggccct
     9061 gccgactagt gagaccttgg ccgcatgact gcatgcagcc aaggtctttt tttttgtgta
     9121 aaacccaaac cccgccaagg agaccgtcat gtctttgcgc gacctgcgtc cctaccttct
     9181 ggctatcctc atgaccttgc cgggcctggc cctgcgcctt gcccctgcgg acgtttcccc
     9241 catgctggtg gccgtactgg ccggcctggc catcctgggc gcgtctttcc tgctgacctg
     9301 ggcctgcgaa gtggcccagc tcgacatccc ccaggccgtg gccgtggccg tggtggcctt
     9361 catcgccgtg ctgcccgaat acgccgtgga catgtacttt acctggatgg cgggccagca
     9421 tcccgaaagc gcctactcgc attatgccat cgccaacatg acgggcgcca accggctgct
     9481 catcggtatc ggctggacgg ccatcgtgct gatcttcgcg ggccgcttcc ataattatgt
     9541 ggccctgcac gaagaaaagc gcaccgacat cctcttcctg ggcatggcca ccctctatgc
     9601 cctgctgatc ccgctcaagg gctccctgac cctgttcgat ggcgtggtct tcctgggcat
     9661 ctatgtggcc tacatgtgca tcatcgcccg ccgtccctgt gaggaagaag agcccgaagg
     9721 cccggcggcc accctggcca agctctcgcg tcccgcccgc atgcgtgccg tggccggtct
     9781 gttcctgttc gcggccctgg tgatcctgtt caacgccgaa cccttcagcg aaagcctggt
     9841 ggccagcggc aagatcctgg gcatcaacga gttcctgctg gtgcagtggc tggcgcccat
     9901 cgcttccgaa gcgccggaat tcatcgtggc cctgatgttc gccttccgcg gcaacgccgg
     9961 tctggccctg ggcagcctgc tgtcctccaa gctcaaccag tggaccctgc tggtgggcat
    10021 gatccccggt gtctacgccg tgtcttccgg cggcaccacc cccatcaacc tggacccgca
    10081 ccagttccag gagatcttcc tcacggccgg ccagtccatc tttgccgtgg ccctgctgct
    10141 ggacctgcgc ctgggcctgc gcgaggcggc ggccctgctg gtgttcttcc tggcccagct
    10201 gttctcgccc ttctatgacg tgcagctgga agccctgctg ggcctgcccc acgacccgct
    10261 gcgcctgcac aacttctatg cctggacgta cctgatcctg gcgggcctgc tcctgctgcg
    10321 gcactggcgc ctggtggccg aactgcgtta cggcttccac gtcaaggtcc gggatatcgt
    10381 gcatcattaa ggccttgcct ccgtctggag gagaggctcc ctacggccgg tcttccccct
    10441 gtccgcgcag ggtcggcaga ccggcctttt atttgctccc gcaaggcttg acagggccgc
    10501 aggagccctc tacaagcagc ttgcggcgcc atgccgcgat ctctttttcc gtcgtctggg
    10561 gggtatgatg ttcagctctg ggaatctccg tcatctgccg ggatcctgtt gccggtccgc
    10621 tcgcatgctt gcgctggcgg ccctgctgtc gtgcttcgca ctgtctcctg atctgtgtcc
    10681 cacggccagc gccgcgcacg ggcacggcac catgctggcc gactcccgtc ccgagcccgc
    10741 ccttgccccc atctccgtca cggattgcaa cctgcgccgc gtttcccggc cgggcaagcc
    10801 ggacatcacc gtcacctatc ccatgctggg ccgcaaggac gtggaccgcg acgtggccga
    10861 ctgggtggag cgcatcgcct cgaccttcga ggccgagctg gcgccgctgg cccttgagtg
    10921 gcaggagcag gaactcccgc cctgcgagct cataggctcc tacaccctga cgcgtccctc
    10981 ggccaatgcc ctgagcatcg tcttcgagat ctggacctac accggcggcg cgcacggcaa
    11041 tctggacgtg atcccgctga cctacagcct gctttccggc cagcgtctgg ggctggtgga
    11101 catcttcgag aacgtggaca aggctctgga gatcatgtcc gccgtgtccc ggaaggagct
    11161 tgccacccgt ctgggcggcg gccgggtgga cagcatgatc cacgacggca ccgagcccct
    11221 ggcggacaat ttttccgcgc tggccctggt gcccggcggg gtgcgtgtct acttccagcc
    11281 ttatcaggtg gctccctggg ccgccgggac gcagcgcgtc ttcatcccgc tggaaaaact
    11341 ggctccggcc ggtcccctgc atctgctctg gggcgaatga tgccgcccct ggaggccgtg
    11401 ctgcgctttc ccggccatgc gcccttgctg gccgaccatt tccccggtgc gccccgtgtg
    11461 cccggttcct gccttttgga agccatgcgc cgggccgtgg aagaggcctt cccgtcccgt
    11521 cgtgtccgtg ccgtacgccg ggcacgcttc cgccatttcg tcctgcctga cagcgacctg
    11581 ctgtgccgta tggagcctga agacaggggc gacgccctgc cgtctgaggt ccgctgccgt
    11641 ctgctgcacg gcgatgcctg cctggccgaa gccgtgttct ctctggagtg aggggaaggc
    11701 agccctattt tcaaggggat cttgccgaag gagacgaagg aggcttgggg aaaagcgccc
    11761 ttttccgcct tctggagctt ccatcttccc gcaaaaaact tccttccggt cattggcggg
    11821 tcgtgcgctg tgcagagcgg acgcgcggct gccggtctcc cgtttttgtc gcgaactcga
    11881 tgggcctcat gtccggcgca tcttcaggcc ttatcccggc ctgtccatgg cctggcgcag
    11941 gccgtgtgcg gcagggcctt gcgcccgggc cgcttttttt tcactatgcg gccatgcgat
    12001 tgacgttcca tggttctgtc ctcatccttg gcggcagcag cgagctgggc cgtgccctgg
    12061 cgctggcctt gcgcgccgaa ggggcgcagg tctgctgtgt ctgccgtgat gacgcaggct
    12121 gcgcccgctg tgcgcaggac ggcctgcccg cccttgtcct tggcgatccc gagaccctgc
    12181 ccgcccgctg tgaagccctg ctgggccggc cggtggggca tctggcggat ctgctgcatt
    12241 cccgtttcga acagctggtg gccatggcgg cgcccgaggc catagagcgc tgggcggatg
    12301 atgacatcgc cctgcgtgcc cgctgcctgc gtgccgtgag ccgggccatg ctggcccgcc
    12361 gtttcggccg ttgtgtcttc gtctcgtcca gtgccgcgca gcggccgtcg cccgggcagg
    12421 gctggtacgc cgcggccaag ctggccggtg agggcctgta ccgcagcctc ggcgtggagc
    12481 tggccggacg cggcctcagc gcctgttccg cccgtctgag ctggctggat gccggacgcg
    12541 ggcacgaatt cctttcccgc cacgggcagg tggcccgtgc catgcccgcc gggcgctgcc
    12601 tgggcccgga cgacgtgctg ccgggcctgt gcttcctgct gtcggcggag gccgcggcca
    12661 tcaacggcag cgtggtgact cttgacgggg gcctcggggc cctcaaactc ccggagctgt
    12721 gatgcgatac gacgagatca gcctcaaggt gcgcgagatc gtggccaatc tgttcgagcg
    12781 cgatgccgcg accctgagcg acgataccct gctcatgcag gatctgccct gtgaatccat
    12841 cgacctgctg gaagtgagcg tgcagctggg cgccaccttc catatctttg tggacgagga
    12901 gcgcgccttc ctgcgttccc tgcgttacca gctggccggc gccccggatg cggccgcctt
    12961 tttgcgcgag cattacggcc atctggacga agcgcggcgg cagcagctgg ccgcctatta
    13021 tacggatgcc gacggcatgg ccctgcaatc gcccctgacc ctgggcgaca tcgcccactg
    13081 ggtggaacag gcccttgagg ccacacggca gggggcctga tggccgtgcc tgagcgggtc
    13141 gtcatcagcg gtgcgggctg ttgcacggcg ctgggccatg atctggacag cgtggcccgc
    13201 agcctgcgcg agggccgtga tgcctttcgg gcctccggcg cgctggaagg gctttccgtc
    13261 tgcccggcgg aagactgggg ccaggacgag gcccggcagc agttcgaagg ctggcggcat
    13321 cgccattacc tgaaccgggg cagccggatg gctgtccttt cgggcctgcg tgccctgcgt
    13381 gatgccggac tggaggcggg cctgcccgtc cgttcgcaga tcatcgccgc cgtggggccc
    13441 atgctggacg tcaccggtga accgggcctg ccgccgcagg ataccgcgac gctgggcgcg
    13501 ctctggctgc tgcgctggct gcccaatacc gccgccggag cactggcccg ttttgcccgc
    13561 tgccatggcg aggccctgac cgtcaacgcg gcctgcgcct cggccctgca ggccctgggc
    13621 gaaggctggc ggcgcatacg tttcggtctg gccgacgccg tactggtcgc ggccggggac
    13681 agccgccttt cgctgggcgg actgctgggc tatcacaagg cccgggccct cagtctttgt
    13741 gcgcccggta cgggcccgcg tcccttcgac atgggccggg acggcttcgt gcccggtgag
    13801 ggcggcgcgg ccttcgtgct ggagagcctg tcctcggcgc aggccagggg cgcccatgtc
    13861 catgcggaga tcctgggcta cggggcctcc gtggatgccg agagcctgac cgcgcccgaa
    13921 gcacggggca cctgggccga gctggccgtg cggggcgctc tggaagaggc gggcctcgat
    13981 gccgccggac tgggctggct ttcggcccac ggcacgggca cgcagctcaa cgatcaggcc
    14041 gagagcctgc tgtgggaacg cctgctgggc gatgtgcccg gcggcccggc cgtcatggcc
    14101 ttcaaatcct ggctggggca cggttcctcg gcctgcgggg cgctggagct gtgctgtgcg
    14161 ctggccgcct ggcgtgacgg caggatgccg cccgtgcgcc atctggaacg gccctgttcc
    14221 ccccgtctcg acttcgtgcg ggagccccgt cccttcccgt cctcccgcgg cctgctggag
    14281 aatttcggct tcggtggcca gaacgccgcc cttgccgtgg atctgcggcc atgaacacgg
    14341 atttctttct ggatgcgccg tcgcccttcg tcttgctgga tgcggcccgg gccatggact
    14401 ccccaccggg gctcacggcc tggcgccgtt gtgagggcgt gcctttctgg caggtgctgg
    14461 aggccgccgc gcaggcggcc gccctgcaac agcgtgtggc gcgggatttt tcctgtcatg
    14521 ccttcctgct gtccgtggag cgcgctccat ggcctgccgg gcccctgtcc ggcacggcgc
    14581 ggctggacgt gcgggtgacg gcacagggcg gcagtgtggc ggcctcgctg gtgcgcgtgc
    14641 gggggctttg cgggcctggg ggccccctgc cgccgctgga gctggaactg cgcgtgggcc
    14701 tggtgcccta tgatgcctct ttttcccgtg aactgctgga gagccgctac agggagctgt
    14761 actcatgtct gtcccacaac gccgaagcct ttatgactgt ctgaacgacc gcctgcgcgc
    14821 cgatgcccgt ctgggccttg cccgcgacag cgccgccatg gccggaggag ccgccgggcc
    14881 gctgctgtac cgggacggcc gggagtacat ctccttcatg agcaacgacg gtctgggcct
    14941 tgccgccgat gcgcactggc aggcgcgggt ggctgcctgt tttgccgccc atgcgccgtc
    15001 ggcgtcggcc tcgcgtctgg ccgggggccg cagcgatgtg gtggaccagg cctgccgggc
    15061 cgtggccgat tacttcggtt ttgcggaatg tctgttcctg cccagcggtt atcaggccaa
    15121 tctggcctgt gtgaccaccc tgctccagca ggggcaggag gcctttgtgg acaggcgctg
    15181 tcacgccagc gtcatgcgag ccctgccgct ggccggggcg cgcatccggg cctggaacca
    15241 tctggactat gaccatctgg agcgcctgct gtcctccctg ccgctggacg cgccgcagcc
    15301 cgtggtcatg gccgagtccc tgtacagcat ggacggcgcg gccctcgatc tggaacgcat
    15361 ggcggccctg cggcgtcggt acggattttt cctctgtgtg gacgaagccc atgcgctggg
    15421 ggccctgggc cccggcggac gcggtctgtg cgcggcacag gccctgcggg atggtggccg
    15481 ggccccggcc gatctggtgg tgggcacgct gggcaaatcg ctgggcctgt ggggcgcgtt
    15541 cctgctgctg ccccggggct tcacgcccct gttcgagcat ctggcctcgg ccatcatgca
    15601 tagcacggcc ct
//
